ZNF524

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.74914509
2negative regulation of cell killing (GO:0031342)4.74914509
3neutrophil activation involved in immune response (GO:0002283)4.50776361
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.32332862
5antigen processing and presentation of endogenous antigen (GO:0019883)4.24391164
6positive regulation of gamma-delta T cell activation (GO:0046645)4.17664674
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.14232684
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.14232684
9modulation by symbiont of host immune response (GO:0052553)4.14232684
10positive regulation by symbiont of host defense response (GO:0052509)4.14232684
11modulation by symbiont of host defense response (GO:0052031)4.14232684
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.14232684
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.10609218
14response to peptidoglycan (GO:0032494)3.98714740
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.95840401
16negative regulation of erythrocyte differentiation (GO:0045647)3.94663990
17detection of bacterium (GO:0016045)3.71475896
18detection of other organism (GO:0098543)3.67391232
19negative regulation of interleukin-12 production (GO:0032695)3.65071094
20immunoglobulin mediated immune response (GO:0016064)3.54336557
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.48209016
22macrophage activation involved in immune response (GO:0002281)3.36899856
23leukocyte aggregation (GO:0070486)3.33204737
24regulation of mast cell degranulation (GO:0043304)3.23610364
25NIK/NF-kappaB signaling (GO:0038061)3.14395716
26negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.13054889
27regulation of gamma-delta T cell activation (GO:0046643)3.07298206
28barbed-end actin filament capping (GO:0051016)3.00654452
29regulation of myeloid leukocyte mediated immunity (GO:0002886)3.00569054
30neutrophil activation (GO:0042119)3.00247935
31regulation of leukocyte degranulation (GO:0043300)3.00205625
32negative regulation of phagocytosis (GO:0050765)2.98985503
33cellular response to type I interferon (GO:0071357)2.97357254
34type I interferon signaling pathway (GO:0060337)2.97357254
35granulocyte activation (GO:0036230)2.96290813
36detection of external biotic stimulus (GO:0098581)2.96216727
37response to type I interferon (GO:0034340)2.94861154
38lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90724638
39regulation of interferon-beta biosynthetic process (GO:0045357)2.89489156
40Arp2/3 complex-mediated actin nucleation (GO:0034314)2.87843231
41amino sugar catabolic process (GO:0046348)2.86453184
42response to host immune response (GO:0052572)2.84044197
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.84044197
44regulation of mast cell activation involved in immune response (GO:0033006)2.83378992
45regulation of B cell receptor signaling pathway (GO:0050855)2.82718310
46germinal center formation (GO:0002467)2.80659109
47modulation by symbiont of host cellular process (GO:0044068)2.80046398
48response to muramyl dipeptide (GO:0032495)2.78789293
49modulation by virus of host process (GO:0019054)2.76611909
50regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.74627953
51negative regulation of lymphocyte mediated immunity (GO:0002707)2.74526328
52negative regulation of leukocyte mediated immunity (GO:0002704)2.73816161
53regulation of gamma-delta T cell differentiation (GO:0045586)2.73670156
54myeloid dendritic cell differentiation (GO:0043011)2.72208636
55negative regulation of innate immune response (GO:0045824)2.72102447
56response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.70763364
57response to host (GO:0075136)2.70763364
58response to host defenses (GO:0052200)2.70763364
59mannose metabolic process (GO:0006013)2.70226480
60myeloid cell activation involved in immune response (GO:0002275)2.70057118
61tolerance induction (GO:0002507)2.69783309
62positive thymic T cell selection (GO:0045059)2.69536300
63respiratory burst (GO:0045730)2.68804316
64regulation of necrotic cell death (GO:0010939)2.62919261
65regulation of superoxide anion generation (GO:0032928)2.62659992
66defense response to protozoan (GO:0042832)2.61795845
67positive regulation of Cdc42 GTPase activity (GO:0043089)2.60845568
68negative regulation of cytokine production involved in immune response (GO:0002719)2.60122632
69interferon-gamma-mediated signaling pathway (GO:0060333)2.59929306
70regulation of antigen processing and presentation (GO:0002577)2.56512384
71positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.56298492
72pinocytosis (GO:0006907)2.56112542
73myeloid dendritic cell activation (GO:0001773)2.55032282
74pyrimidine nucleoside salvage (GO:0043097)2.53311652
75pyrimidine-containing compound salvage (GO:0008655)2.53311652
76B cell mediated immunity (GO:0019724)2.52696527
77N-acetylneuraminate metabolic process (GO:0006054)2.52448360
78regulation of dendritic cell antigen processing and presentation (GO:0002604)2.51300018
79detection of biotic stimulus (GO:0009595)2.50935235
80positive regulation of B cell differentiation (GO:0045579)2.50583608
81response to protozoan (GO:0001562)2.48922870
82response to interleukin-15 (GO:0070672)2.48785486
83thymic T cell selection (GO:0045061)2.47587501
84cellular extravasation (GO:0045123)2.47545244
85positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.47530410
86negative regulation of interleukin-6 production (GO:0032715)2.47397658
87regulation of T-helper 2 cell differentiation (GO:0045628)2.47221533
88B cell receptor signaling pathway (GO:0050853)2.44067802
89regulation of regulated secretory pathway (GO:1903305)2.43515405
90regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.42970858
91cellular response to thyroid hormone stimulus (GO:0097067)2.42542163
92positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.41972191
93positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.40269585
94cellular response to interleukin-15 (GO:0071350)2.38712137
95regulation of podosome assembly (GO:0071801)2.37729484
96positive regulation of mast cell activation (GO:0033005)2.37241305
97detection of molecule of bacterial origin (GO:0032490)2.36311514
98regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.35413657
99regulation of tumor necrosis factor production (GO:0032680)2.34770705
100T cell selection (GO:0045058)2.34287977

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.13763077
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.99378373
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.76788301
4NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.75289749
5* LXR_22292898_ChIP-Seq_THP-1_Human2.52128265
6* MYC_22102868_ChIP-Seq_BL_Human2.39745802
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.33730141
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.28373929
9* ELK3_25401928_ChIP-Seq_HUVEC_Human2.26706759
10VDR_24763502_ChIP-Seq_THP-1_Human2.26208850
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18749096
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18633133
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.12498002
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.10462653
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04663470
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.03965635
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02347114
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.97468171
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.95399960
20MAF_26560356_Chip-Seq_TH1_Human1.94935553
21TCF7_22412390_ChIP-Seq_EML_Mouse1.92438400
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92067955
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88187628
24* KDM2B_26808549_Chip-Seq_DND41_Human1.83387080
25RACK7_27058665_Chip-Seq_MCF-7_Human1.83329826
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82372798
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.82190832
28* UTX_26944678_Chip-Seq_JUKART_Human1.79294432
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78762977
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74602630
31MAF_26560356_Chip-Seq_TH2_Human1.72004616
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69195668
33SPI1_23547873_ChIP-Seq_NB4_Human1.67318861
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66870453
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.66645022
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64814196
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61703340
38SPI1_23127762_ChIP-Seq_K562_Human1.59012737
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57548383
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56073286
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55371591
42BCL6_27268052_Chip-Seq_Bcells_Human1.53424856
43BCOR_27268052_Chip-Seq_Bcells_Human1.50040356
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49551382
45P68_20966046_ChIP-Seq_HELA_Human1.48661072
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46792749
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.45997578
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44254378
49GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42144366
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.41814380
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41125659
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40362251
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40001699
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.39266124
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39023385
56SCL_19346495_ChIP-Seq_HPC-7_Human1.37277027
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37009775
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36042026
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34604490
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32808833
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32563894
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.32229022
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31420091
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30779704
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.29687727
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28842639
67PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28223921
68PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25110346
69NCOR1_26117541_ChIP-Seq_K562_Human1.25075076
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24596074
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24459578
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24150694
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24130947
74MYB_26560356_Chip-Seq_TH2_Human1.22655131
75MYB_26560356_Chip-Seq_TH1_Human1.20683168
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18911022
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17786179
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16150852
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15786090
80RUNX_20019798_ChIP-Seq_JUKART_Human1.15379909
81CTCF_26484167_Chip-Seq_Bcells_Mouse1.14719130
82* KDM2B_26808549_Chip-Seq_JURKAT_Human1.13578309
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.13492858
84GATA1_19941826_ChIP-Seq_K562_Human1.12858534
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12041337
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11449484
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10567373
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09611901
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09319894
90RXR_22158963_ChIP-Seq_LIVER_Mouse1.09007561
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08162072
92SMC4_20622854_ChIP-Seq_HELA_Human1.07832491
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05879542
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05730054
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05452913
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04358071
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03266886
98SA1_27219007_Chip-Seq_Bcells_Human1.02508520
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01472862
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00504520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.62167915
2MP0003303_peritoneal_inflammation3.42522413
3MP0005058_abnormal_lysosome_morphology3.07190202
4MP0003724_increased_susceptibility_to2.75867889
5MP0005451_abnormal_body_composition2.75194159
6MP0001835_abnormal_antigen_presentation2.62949146
7MP0002419_abnormal_innate_immunity2.46847545
8MP0005025_abnormal_response_to2.41997356
9MP0000685_abnormal_immune_system2.39516617
10MP0003191_abnormal_cellular_cholesterol2.39314170
11MP0005387_immune_system_phenotype2.37939983
12MP0001790_abnormal_immune_system2.37939983
13MP0005000_abnormal_immune_tolerance2.35535593
14MP0005671_abnormal_response_to2.34005958
15MP0009840_abnormal_foam_cell2.30807261
16MP0002148_abnormal_hypersensitivity_rea2.27283650
17MP0003300_gastrointestinal_ulcer2.26952663
18MP0004510_myositis2.25105543
19MP0006082_CNS_inflammation2.23665514
20MP0009785_altered_susceptibility_to2.16954704
21MP0001800_abnormal_humoral_immune2.09066623
22MP0008260_abnormal_autophagy2.08874068
23MP0005464_abnormal_platelet_physiology2.04970642
24MP0002723_abnormal_immune_serum2.04871874
25MP0002452_abnormal_antigen_presenting1.98537825
26MP0002420_abnormal_adaptive_immunity1.95775952
27MP0001819_abnormal_immune_cell1.94667981
28MP0003172_abnormal_lysosome_physiology1.92456745
29MP0004947_skin_inflammation1.91600138
30MP0009333_abnormal_splenocyte_physiolog1.90683019
31MP0010155_abnormal_intestine_physiology1.87226095
32MP0001533_abnormal_skeleton_physiology1.86553346
33MP0003763_abnormal_thymus_physiology1.84550473
34MP0001545_abnormal_hematopoietic_system1.81707677
35MP0005397_hematopoietic_system_phenotyp1.81707677
36MP0009278_abnormal_bone_marrow1.77410305
37MP0001845_abnormal_inflammatory_respons1.60855472
38MP0003075_altered_response_to1.57149446
39MP0002405_respiratory_system_inflammati1.54017186
40MP0000858_altered_metastatic_potential1.52388228
41MP0000716_abnormal_immune_system1.47975671
42MP0002398_abnormal_bone_marrow1.47207023
43MP0001853_heart_inflammation1.46847469
44MP0001873_stomach_inflammation1.44567689
45MP0000343_altered_response_to1.43439727
46MP0003705_abnormal_hypodermis_morpholog1.42703944
47MP0004858_abnormal_nervous_system1.42307694
48MP0000465_gastrointestinal_hemorrhage1.42050652
49MP0002998_abnormal_bone_remodeling1.40442464
50MP0008469_abnormal_protein_level1.39429913
51MP0003866_abnormal_defecation1.38360113
52MP0004185_abnormal_adipocyte_glucose1.36230632
53MP0003806_abnormal_nucleotide_metabolis1.31876873
54MP0003453_abnormal_keratinocyte_physiol1.28427917
55MP0002429_abnormal_blood_cell1.25831962
56MP0002722_abnormal_immune_system1.24179420
57MP0000689_abnormal_spleen_morphology1.22979868
58MP0003828_pulmonary_edema1.22368631
59MP0009764_decreased_sensitivity_to1.21265024
60MP0003183_abnormal_peptide_metabolism1.20423655
61MP0005310_abnormal_salivary_gland1.19272178
62MP0000604_amyloidosis1.15410519
63MP0005083_abnormal_biliary_tract1.14561386
64MP0005166_decreased_susceptibility_to1.13471987
65MP0005666_abnormal_adipose_tissue1.11454082
66MP0000490_abnormal_crypts_of1.11162138
67MP0008004_abnormal_stomach_pH1.07067098
68MP0002933_joint_inflammation1.02284487
69MP0003656_abnormal_erythrocyte_physiolo1.02161116
70MP0001663_abnormal_digestive_system1.01163583
71MP0002132_abnormal_respiratory_system0.97640726
72MP0000703_abnormal_thymus_morphology0.97003466
73MP0001851_eye_inflammation0.91858199
74MP0005375_adipose_tissue_phenotype0.87094753
75MP0002396_abnormal_hematopoietic_system0.85888361
76MP0005390_skeleton_phenotype0.85385230
77MP0000750_abnormal_muscle_regeneration0.85168390
78MP0005076_abnormal_cell_differentiation0.85077962
79MP0004883_abnormal_blood_vessel0.83776707
80MP0001849_ear_inflammation0.80115872
81MP0005164_abnormal_response_to0.79966792
82MP0002139_abnormal_hepatobiliary_system0.79732666
83MP0003448_altered_tumor_morphology0.78320141
84MP0004381_abnormal_hair_follicle0.77992648
85MP0002332_abnormal_exercise_endurance0.77877123
86MP0000249_abnormal_blood_vessel0.77663325
87MP0003795_abnormal_bone_structure0.77452930
88MP0003279_aneurysm0.76756161
89MP0005165_increased_susceptibility_to0.76604119
90MP0005365_abnormal_bile_salt0.75321491
91MP0004130_abnormal_muscle_cell0.75233869
92MP0002796_impaired_skin_barrier0.75172722
93MP0008874_decreased_physiological_sensi0.75110432
94MP0009763_increased_sensitivity_to0.72985221
95MP0000747_muscle_weakness0.72766227
96MP0000609_abnormal_liver_physiology0.70755809
97MP0003566_abnormal_cell_adhesion0.70366997
98MP0003646_muscle_fatigue0.69596662
99MP0005381_digestive/alimentary_phenotyp0.69416632
100MP0005319_abnormal_enzyme/_coenzyme0.69023972

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.73326928
2Abnormality of macrophages (HP:0004311)4.26470512
3Recurrent abscess formation (HP:0002722)4.12086520
4Recurrent bacterial skin infections (HP:0005406)3.95773738
5Abnormality of glycolipid metabolism (HP:0010969)3.89068047
6Abnormality of liposaccharide metabolism (HP:0010968)3.89068047
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.89068047
8Myositis (HP:0100614)3.61163085
9Elevated erythrocyte sedimentation rate (HP:0003565)3.43647949
10Petechiae (HP:0000967)3.25973560
11Chronic obstructive pulmonary disease (HP:0006510)3.20179106
12Obstructive lung disease (HP:0006536)3.20179106
13Orchitis (HP:0100796)3.11498725
14Purpura (HP:0000979)3.06514720
15Increased cerebral lipofuscin (HP:0011813)3.05186967
16Dysostosis multiplex (HP:0000943)3.04022658
17Recurrent gram-negative bacterial infections (HP:0005420)3.03848657
18Systemic lupus erythematosus (HP:0002725)2.98332839
19Distal lower limb muscle weakness (HP:0009053)2.96532552
20Mediastinal lymphadenopathy (HP:0100721)2.91905231
21Increased IgE level (HP:0003212)2.90160528
22Cellulitis (HP:0100658)2.89882700
23Loss of speech (HP:0002371)2.77669203
24Stomatitis (HP:0010280)2.72373453
25Meningitis (HP:0001287)2.71578165
26Prolonged bleeding time (HP:0003010)2.66425552
27Increased serum ferritin (HP:0003281)2.63530487
28Gastrointestinal infarctions (HP:0005244)2.63420392
29Hepatosplenomegaly (HP:0001433)2.62473644
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.61494798
31Spontaneous hematomas (HP:0007420)2.61378108
32Vasculitis (HP:0002633)2.59555544
33Amyloidosis (HP:0011034)2.56099340
34Disinhibition (HP:0000734)2.55837906
35Recurrent fungal infections (HP:0002841)2.55239269
36Retrobulbar optic neuritis (HP:0100654)2.53346955
37Optic neuritis (HP:0100653)2.53346955
38Recurrent skin infections (HP:0001581)2.48834413
39Axonal loss (HP:0003447)2.46842804
40Vertebral compression fractures (HP:0002953)2.44790215
41Gingivitis (HP:0000230)2.41108881
42Vacuolated lymphocytes (HP:0001922)2.40691546
43Myopathic facies (HP:0002058)2.40158084
44Urticaria (HP:0001025)2.35880601
45Personality changes (HP:0000751)2.34071194
46Colitis (HP:0002583)2.31940897
47Gastrointestinal stroma tumor (HP:0100723)2.31771699
48Gastrointestinal inflammation (HP:0004386)2.31589507
49Upper motor neuron abnormality (HP:0002127)2.28580896
50Epistaxis (HP:0000421)2.28231531
51Abnormality of the nasal mucosa (HP:0000433)2.26690933
52Increased connective tissue (HP:0009025)2.26550325
53Inflammation of the large intestine (HP:0002037)2.24871560
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22404590
55Abnormality of polysaccharide metabolism (HP:0011012)2.22404590
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22404590
57Abnormality of iron homeostasis (HP:0011031)2.20699974
58Pustule (HP:0200039)2.19577688
59Recurrent viral infections (HP:0004429)2.17109142
60Progressive neurologic deterioration (HP:0002344)2.16447887
61Hypertensive crisis (HP:0100735)2.12968719
62Centrally nucleated skeletal muscle fibers (HP:0003687)2.08250453
63Hypertriglyceridemia (HP:0002155)2.06885174
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.06421314
65Exercise-induced myalgia (HP:0003738)2.06346847
66Ragged-red muscle fibers (HP:0003200)2.05312264
67Encephalitis (HP:0002383)2.04886792
68Mucopolysacchariduria (HP:0008155)2.04362737
69Urinary glycosaminoglycan excretion (HP:0003541)2.04362737
70Agammaglobulinemia (HP:0004432)2.02547917
71Bulbar palsy (HP:0001283)2.01854452
72Asymmetric septal hypertrophy (HP:0001670)2.00757539
73Malnutrition (HP:0004395)2.00579704
74Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.99269793
75Nasal polyposis (HP:0100582)1.99131769
76Polycythemia (HP:0001901)1.98919950
77Chest pain (HP:0100749)1.97227350
78Acute hepatic failure (HP:0006554)1.95506232
79Pulmonary infiltrates (HP:0002113)1.94149553
80Chronic mucocutaneous candidiasis (HP:0002728)1.92312076
81Recurrent cutaneous fungal infections (HP:0011370)1.92312076
82Increased IgM level (HP:0003496)1.89842709
83Stridor (HP:0010307)1.89796080
84Distal lower limb amyotrophy (HP:0008944)1.88451106
85Easy fatigability (HP:0003388)1.88253560
86Hypergammaglobulinemia (HP:0010702)1.87999712
87Thoracic kyphosis (HP:0002942)1.86669392
88Cholecystitis (HP:0001082)1.86628679
89Abnormal gallbladder physiology (HP:0012438)1.86628679
90Episodic fever (HP:0001954)1.86083453
91Interstitial pulmonary disease (HP:0006530)1.83669428
92Hemorrhage of the eye (HP:0011885)1.83339237
93Emphysema (HP:0002097)1.83294971
94Osteomyelitis (HP:0002754)1.82410290
95Hemoptysis (HP:0002105)1.80226190
96Restrictive lung disease (HP:0002091)1.78832833
97Keratoconjunctivitis sicca (HP:0001097)1.78541364
98Polygenic inheritance (HP:0010982)1.78286765
99Gingival bleeding (HP:0000225)1.76766802
100Rhabdomyolysis (HP:0003201)1.75739020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.79058714
2RIPK43.45752444
3NME23.27650108
4MAP4K13.25701403
5TRIB32.83754360
6PRPF4B2.68651155
7MAP3K112.50541522
8MAP2K32.33289867
9IRAK32.26269079
10TYK22.00328663
11TBK11.95206946
12SIK11.93395884
13BLK1.88066038
14TAOK11.86817084
15IRAK41.86432200
16TAOK21.85790894
17MAP3K31.84241100
18SMG11.82457931
19GRK61.77445080
20TESK21.76583971
21ZAP701.69776047
22TNK21.65445607
23CSK1.64946422
24TESK11.63734200
25EPHB11.35639042
26MAP3K11.32688568
27TTN1.30907548
28MAP3K131.30459333
29FES1.30298709
30TGFBR21.26770602
31ARAF1.23777554
32MAP3K141.23756305
33JAK31.23324708
34BTK1.22388551
35PIM21.18596281
36PRKD21.14258563
37RIPK11.14253772
38IKBKE1.10171828
39IKBKB1.05931228
40SYK1.04528649
41LRRK20.99780132
42SIK30.93210971
43HCK0.92536756
44IRAK20.92057529
45PDPK10.89163050
46CSF1R0.89023981
47JAK10.86155883
48ICK0.85648831
49BMX0.83869654
50CDC42BPA0.81624081
51PTK60.80650601
52MARK20.80503556
53FGR0.80405028
54EPHA20.80080869
55KDR0.78912110
56PAK40.78323119
57MAPK120.78003632
58LYN0.76929891
59PKN20.75112323
60STK100.73019352
61ABL20.72573627
62MAPKAPK30.71514668
63MATK0.71489220
64KIT0.71317912
65MOS0.70800235
66LCK0.70309699
67EEF2K0.68524802
68PDK10.66036883
69HIPK20.65258959
70BCKDK0.64300696
71TXK0.63790892
72RPS6KL10.62665423
73RPS6KC10.62665423
74JAK20.62479062
75BMPR20.60061306
76MAPKAPK20.56607247
77MAP3K60.55251357
78RPS6KA20.54204325
79MARK30.52910130
80PRKG20.52579278
81KSR20.52560485
82FGFR40.52245099
83MAP3K80.51610159
84MAPK110.51028933
85BRAF0.48327332
86SIK20.47802762
87MAP2K20.47664230
88GRK70.47555459
89RPS6KA60.46901487
90MAPK40.41857822
91ITK0.40771467
92IRAK10.40425904
93ILK0.38055403
94MAP2K60.37274348
95DYRK1B0.37162883
96MAP3K70.36639673
97MAPK70.34101376
98CDK40.33977272
99DAPK30.33784256
100PRKCQ0.33634193

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.09168732
2Osteoclast differentiation_Homo sapiens_hsa043802.70090246
3Leishmaniasis_Homo sapiens_hsa051402.45346884
4Staphylococcus aureus infection_Homo sapiens_hsa051502.33611913
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.16525645
6Allograft rejection_Homo sapiens_hsa053302.13960349
7Graft-versus-host disease_Homo sapiens_hsa053321.99790487
8Primary immunodeficiency_Homo sapiens_hsa053401.99695654
9B cell receptor signaling pathway_Homo sapiens_hsa046621.99546169
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94892430
11Acute myeloid leukemia_Homo sapiens_hsa052211.94849178
12Autoimmune thyroid disease_Homo sapiens_hsa053201.94047984
13Tuberculosis_Homo sapiens_hsa051521.88973432
14Lysosome_Homo sapiens_hsa041421.87586210
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.72306219
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69419837
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63308703
18Malaria_Homo sapiens_hsa051441.61648308
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.60557723
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.54269907
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50480939
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.49811570
23Antigen processing and presentation_Homo sapiens_hsa046121.48042975
24Hematopoietic cell lineage_Homo sapiens_hsa046401.46356110
25Toxoplasmosis_Homo sapiens_hsa051451.43094836
26Asthma_Homo sapiens_hsa053101.42784195
27Pertussis_Homo sapiens_hsa051331.39609832
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38872774
29Viral myocarditis_Homo sapiens_hsa054161.37480616
30TNF signaling pathway_Homo sapiens_hsa046681.33706242
31Influenza A_Homo sapiens_hsa051641.30565607
32Type I diabetes mellitus_Homo sapiens_hsa049401.27691836
33Fructose and mannose metabolism_Homo sapiens_hsa000511.27165799
34Phagosome_Homo sapiens_hsa041451.26607613
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23150156
36T cell receptor signaling pathway_Homo sapiens_hsa046601.22875646
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.20523049
38Pentose phosphate pathway_Homo sapiens_hsa000301.20117288
39Rheumatoid arthritis_Homo sapiens_hsa053231.18896748
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18527598
41Hepatitis C_Homo sapiens_hsa051601.17422625
42Shigellosis_Homo sapiens_hsa051311.17145662
43Herpes simplex infection_Homo sapiens_hsa051681.16405344
44Chemokine signaling pathway_Homo sapiens_hsa040621.15931114
45Measles_Homo sapiens_hsa051621.15578295
46Salmonella infection_Homo sapiens_hsa051321.15512328
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11238356
48VEGF signaling pathway_Homo sapiens_hsa043701.08676821
49Galactose metabolism_Homo sapiens_hsa000521.07424073
50Legionellosis_Homo sapiens_hsa051341.06779573
51Apoptosis_Homo sapiens_hsa042101.04107477
52Adipocytokine signaling pathway_Homo sapiens_hsa049201.02957619
53Chronic myeloid leukemia_Homo sapiens_hsa052201.01327197
54Non-small cell lung cancer_Homo sapiens_hsa052231.00245343
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.96250869
56Endocytosis_Homo sapiens_hsa041440.96044795
57Sulfur relay system_Homo sapiens_hsa041220.94525622
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93626511
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93455818
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92991750
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91676486
62Pancreatic cancer_Homo sapiens_hsa052120.91164564
63Hepatitis B_Homo sapiens_hsa051610.90670619
64Bladder cancer_Homo sapiens_hsa052190.90192692
65African trypanosomiasis_Homo sapiens_hsa051430.89241983
66Notch signaling pathway_Homo sapiens_hsa043300.88519881
67Platelet activation_Homo sapiens_hsa046110.87826987
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83484454
69Prion diseases_Homo sapiens_hsa050200.80684122
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.77739877
71Amoebiasis_Homo sapiens_hsa051460.73878873
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.72301962
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70461077
74Insulin resistance_Homo sapiens_hsa049310.69407407
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68462038
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64589677
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.64210431
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.64162302
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63428394
80HTLV-I infection_Homo sapiens_hsa051660.61595208
81Insulin signaling pathway_Homo sapiens_hsa049100.61229996
82Epstein-Barr virus infection_Homo sapiens_hsa051690.60902037
83Viral carcinogenesis_Homo sapiens_hsa052030.58237472
84Prolactin signaling pathway_Homo sapiens_hsa049170.55121000
85Renal cell carcinoma_Homo sapiens_hsa052110.51805761
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47885054
87Vibrio cholerae infection_Homo sapiens_hsa051100.46945697
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46025479
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44802418
90HIF-1 signaling pathway_Homo sapiens_hsa040660.43517646
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.43461361
92mTOR signaling pathway_Homo sapiens_hsa041500.42148296
93GnRH signaling pathway_Homo sapiens_hsa049120.40836555
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40562054
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38982330
96PPAR signaling pathway_Homo sapiens_hsa033200.38780501
97Collecting duct acid secretion_Homo sapiens_hsa049660.35128593
98Renin-angiotensin system_Homo sapiens_hsa046140.34686282
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.33306997
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32916888

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