ZNF525

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)4.70576114
2regulation of gene silencing by miRNA (GO:0060964)4.70576114
3regulation of gene silencing by RNA (GO:0060966)4.70576114
4regulation of centriole replication (GO:0046599)4.10351706
5centriole replication (GO:0007099)4.03182318
6regulation of meiosis I (GO:0060631)3.99938172
7RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.90676718
8negative regulation of DNA-dependent DNA replication (GO:2000104)3.79813731
9DNA double-strand break processing (GO:0000729)3.79060357
10regulation of histone H3-K9 methylation (GO:0051570)3.72436254
11regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.71074035
12regulation of mitotic spindle checkpoint (GO:1903504)3.71074035
13response to pheromone (GO:0019236)3.68010369
14single strand break repair (GO:0000012)3.61371689
15piRNA metabolic process (GO:0034587)3.51692732
16regulation of nuclear cell cycle DNA replication (GO:0033262)3.45128622
17ncRNA catabolic process (GO:0034661)3.43866375
18positive regulation of histone H3-K4 methylation (GO:0051571)3.39096831
19replication fork processing (GO:0031297)3.36288105
20negative regulation of translation, ncRNA-mediated (GO:0040033)3.35941048
21regulation of translation, ncRNA-mediated (GO:0045974)3.35941048
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.35941048
23somatic diversification of immune receptors via somatic mutation (GO:0002566)3.31994295
24somatic hypermutation of immunoglobulin genes (GO:0016446)3.31994295
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30518039
26chromatin remodeling at centromere (GO:0031055)3.30046183
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24344807
28double-strand break repair via homologous recombination (GO:0000724)3.16425392
29regulation of gene silencing (GO:0060968)3.16057837
30recombinational repair (GO:0000725)3.16036436
31DNA replication-dependent nucleosome assembly (GO:0006335)3.15350265
32DNA replication-dependent nucleosome organization (GO:0034723)3.15350265
33CENP-A containing nucleosome assembly (GO:0034080)3.13059120
34protein prenylation (GO:0018342)3.09359267
35prenylation (GO:0097354)3.09359267
36histone exchange (GO:0043486)3.09200218
37regulation of chromatin silencing (GO:0031935)3.08947594
38synapsis (GO:0007129)3.08019486
39nuclear pore organization (GO:0006999)3.07354152
40pre-miRNA processing (GO:0031054)3.06586448
41nuclear pore complex assembly (GO:0051292)3.06564204
42regulation of helicase activity (GO:0051095)3.05198071
43rRNA catabolic process (GO:0016075)3.04900050
44histone mRNA metabolic process (GO:0008334)2.88665940
45mitotic sister chromatid cohesion (GO:0007064)2.87647376
46reciprocal DNA recombination (GO:0035825)2.86886771
47reciprocal meiotic recombination (GO:0007131)2.86886771
48centriole assembly (GO:0098534)2.85205322
49regulation of centrosome cycle (GO:0046605)2.81797214
50DNA deamination (GO:0045006)2.80754266
51regulation of DNA endoreduplication (GO:0032875)2.80602142
52DNA demethylation (GO:0080111)2.79224338
53somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.78540638
54somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.78540638
55isotype switching (GO:0045190)2.78540638
56regulation of centrosome duplication (GO:0010824)2.77767704
57maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75278566
58sister chromatid cohesion (GO:0007062)2.75027501
59negative regulation of gene silencing (GO:0060969)2.74846273
60meiotic cell cycle (GO:0051321)2.72415659
61meiotic chromosome segregation (GO:0045132)2.69197210
62DNA dealkylation (GO:0035510)2.69035974
63neural tube formation (GO:0001841)2.68168742
64resolution of meiotic recombination intermediates (GO:0000712)2.67181230
65postreplication repair (GO:0006301)2.67102225
66DNA methylation involved in gamete generation (GO:0043046)2.65187197
67fucose catabolic process (GO:0019317)2.63839754
68L-fucose metabolic process (GO:0042354)2.63839754
69L-fucose catabolic process (GO:0042355)2.63839754
70multicellular organism reproduction (GO:0032504)2.62500913
71histone mRNA catabolic process (GO:0071044)2.62487788
72male meiosis (GO:0007140)2.60331335
73DNA replication checkpoint (GO:0000076)2.60278429
74protein localization to kinetochore (GO:0034501)2.59808693
75gene silencing by RNA (GO:0031047)2.59475884
76telomere maintenance via telomerase (GO:0007004)2.56053155
77kidney morphogenesis (GO:0060993)2.54437514
78protein K11-linked deubiquitination (GO:0035871)2.52008358
79proteasome assembly (GO:0043248)2.51393296
80positive regulation of histone methylation (GO:0031062)2.50217091
81rRNA methylation (GO:0031167)2.48096269
82negative regulation of DNA recombination (GO:0045910)2.47232022
83DNA catabolic process, exonucleolytic (GO:0000738)2.47187701
84double-strand break repair (GO:0006302)2.46844104
85rRNA modification (GO:0000154)2.46300320
86DNA recombination (GO:0006310)2.45203792
87somatic diversification of immunoglobulins (GO:0016445)2.43992173
88base-excision repair, AP site formation (GO:0006285)2.43168001
89microtubule depolymerization (GO:0007019)2.43147170
90somatic recombination of immunoglobulin gene segments (GO:0016447)2.42823674
91negative regulation of sister chromatid segregation (GO:0033046)2.41939539
92negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.41939539
93negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.41939539
94negative regulation of mitotic sister chromatid segregation (GO:0033048)2.41939539
95negative regulation of mitotic sister chromatid separation (GO:2000816)2.41939539
96response to X-ray (GO:0010165)2.40738295
97DNA replication-independent nucleosome organization (GO:0034724)2.40337893
98DNA replication-independent nucleosome assembly (GO:0006336)2.40337893
99replicative senescence (GO:0090399)2.40332828
100mitotic G2/M transition checkpoint (GO:0044818)2.40060184

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.51195679
2ZNF274_21170338_ChIP-Seq_K562_Hela3.45170736
3E2F7_22180533_ChIP-Seq_HELA_Human3.40219159
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.14610945
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.85840376
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84270057
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63002634
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.54965263
9VDR_22108803_ChIP-Seq_LS180_Human2.52801435
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.45647005
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.44953927
12FUS_26573619_Chip-Seq_HEK293_Human2.43596613
13IGF1R_20145208_ChIP-Seq_DFB_Human2.36997098
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.36126497
15EWS_26573619_Chip-Seq_HEK293_Human2.35801064
16TAF15_26573619_Chip-Seq_HEK293_Human2.33525642
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.29604077
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27489101
19ELK1_19687146_ChIP-ChIP_HELA_Human2.16399831
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12813465
21GBX2_23144817_ChIP-Seq_PC3_Human1.93452903
22P300_19829295_ChIP-Seq_ESCs_Human1.93010569
23VDR_23849224_ChIP-Seq_CD4+_Human1.86228345
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85739363
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77838260
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74311633
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74015466
28ER_23166858_ChIP-Seq_MCF-7_Human1.71402190
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68502843
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63485055
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63307094
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62830271
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62487687
34* CBP_20019798_ChIP-Seq_JUKART_Human1.62283514
35* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62283514
36FOXP3_21729870_ChIP-Seq_TREG_Human1.54895530
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53563131
38MYC_18940864_ChIP-ChIP_HL60_Human1.52938614
39IRF1_19129219_ChIP-ChIP_H3396_Human1.51306505
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50645115
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43113281
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.40571948
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37054114
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36623803
45TP53_22573176_ChIP-Seq_HFKS_Human1.32372548
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32304206
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32019878
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32019878
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28364103
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27177006
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26426664
52STAT3_23295773_ChIP-Seq_U87_Human1.24439714
53TCF4_23295773_ChIP-Seq_U87_Human1.23944013
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.23656739
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23445016
56KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23333322
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22524253
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.21262229
59* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20921142
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19826500
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.19157099
62BCAT_22108803_ChIP-Seq_LS180_Human1.18913060
63NANOG_16153702_ChIP-ChIP_HESCs_Human1.16168075
64NANOG_19829295_ChIP-Seq_ESCs_Human1.15807470
65SOX2_19829295_ChIP-Seq_ESCs_Human1.15807470
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13647182
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.13585395
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12097230
69SMAD4_21799915_ChIP-Seq_A2780_Human1.11206690
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.10940487
71AR_21572438_ChIP-Seq_LNCaP_Human1.09764538
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09298368
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.08631997
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08631997
75TCF4_22108803_ChIP-Seq_LS180_Human1.08582564
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07971300
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04737336
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04635596
79AR_25329375_ChIP-Seq_VCAP_Human1.03893887
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03481861
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01396027
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00728074
83PIAS1_25552417_ChIP-Seq_VCAP_Human0.99851659
84* RUNX2_22187159_ChIP-Seq_PCA_Human0.98487282
85CDX2_22108803_ChIP-Seq_LS180_Human0.98418861
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98085158
87HOXB7_26014856_ChIP-Seq_BT474_Human0.97528085
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97444482
89NANOG_18555785_Chip-Seq_ESCs_Mouse0.97048591
90E2F1_21310950_ChIP-Seq_MCF-7_Human0.95953225
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95764523
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.94567801
93P300_18555785_Chip-Seq_ESCs_Mouse0.93476901
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92738289
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92444435
96SMAD4_21741376_ChIP-Seq_EPCs_Human0.92084337
97E2F1_18555785_Chip-Seq_ESCs_Mouse0.91622187
98MYC_18555785_ChIP-Seq_MESCs_Mouse0.90722030
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90436772
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90160274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.47728282
2MP0008877_abnormal_DNA_methylation4.26597779
3MP0008058_abnormal_DNA_repair3.02056353
4MP0003718_maternal_effect2.86723937
5MP0003693_abnormal_embryo_hatching2.82692607
6MP0003890_abnormal_embryonic-extraembry2.82268975
7MP0002254_reproductive_system_inflammat2.73679422
8MP0010094_abnormal_chromosome_stability2.69649861
9MP0002102_abnormal_ear_morphology2.34765776
10MP0004957_abnormal_blastocyst_morpholog2.02509875
11MP0005645_abnormal_hypothalamus_physiol1.99440277
12MP0006292_abnormal_olfactory_placode1.94056812
13MP0003787_abnormal_imprinting1.88594078
14MP0003941_abnormal_skin_development1.87449967
15MP0006072_abnormal_retinal_apoptosis1.78034978
16MP0005410_abnormal_fertilization1.73704210
17MP0005646_abnormal_pituitary_gland1.72858673
18MP0003077_abnormal_cell_cycle1.69618828
19MP0003646_muscle_fatigue1.69381578
20MP0000427_abnormal_hair_cycle1.66148313
21MP0003567_abnormal_fetal_cardiomyocyte1.64570432
22MP0001929_abnormal_gametogenesis1.64371966
23MP0005551_abnormal_eye_electrophysiolog1.62147045
24MP0005075_abnormal_melanosome_morpholog1.61565451
25MP0003111_abnormal_nucleus_morphology1.54828306
26MP0002736_abnormal_nociception_after1.48644387
27MP0000383_abnormal_hair_follicle1.45290052
28MP0001968_abnormal_touch/_nociception1.44020173
29MP0001919_abnormal_reproductive_system1.42558222
30MP0002210_abnormal_sex_determination1.41824392
31MP0008872_abnormal_physiological_respon1.36520623
32MP0003698_abnormal_male_reproductive1.36367533
33MP0008995_early_reproductive_senescence1.35705758
34MP0003195_calcinosis1.34676682
35MP0005253_abnormal_eye_physiology1.34541757
36MP0003136_yellow_coat_color1.30906284
37MP0000569_abnormal_digit_pigmentation1.30099563
38MP0003121_genomic_imprinting1.29295222
39MP0001529_abnormal_vocalization1.26168021
40MP0000372_irregular_coat_pigmentation1.25735163
41MP0008007_abnormal_cellular_replicative1.24439448
42MP0009697_abnormal_copulation1.23060057
43MP0005389_reproductive_system_phenotype1.22379563
44MP0001145_abnormal_male_reproductive1.22294648
45MP0002163_abnormal_gland_morphology1.17955013
46MP0005647_abnormal_sex_gland1.15993623
47MP0000653_abnormal_sex_gland1.15571751
48MP0003878_abnormal_ear_physiology1.15263870
49MP0005377_hearing/vestibular/ear_phenot1.15263870
50MP0010307_abnormal_tumor_latency1.14726958
51MP0003786_premature_aging1.14082788
52MP0001984_abnormal_olfaction1.13062980
53MP0000647_abnormal_sebaceous_gland1.12383713
54MP0001188_hyperpigmentation1.09901377
55MP0001485_abnormal_pinna_reflex1.09480579
56MP0000631_abnormal_neuroendocrine_gland1.09399442
57MP0001293_anophthalmia1.09018176
58MP0006035_abnormal_mitochondrial_morpho1.07545597
59MP0002160_abnormal_reproductive_system1.06184697
60MP0010678_abnormal_skin_adnexa1.05371765
61MP0003119_abnormal_digestive_system1.03358951
62MP0002009_preneoplasia1.01332620
63MP0008789_abnormal_olfactory_epithelium1.00929080
64MP0006276_abnormal_autonomic_nervous1.00688271
65MP0002138_abnormal_hepatobiliary_system0.99436163
66MP0003011_delayed_dark_adaptation0.99321943
67MP0008932_abnormal_embryonic_tissue0.98570434
68MP0004147_increased_porphyrin_level0.98192863
69MP0003937_abnormal_limbs/digits/tail_de0.97998300
70MP0002751_abnormal_autonomic_nervous0.97694828
71MP0005671_abnormal_response_to0.96635288
72MP0001119_abnormal_female_reproductive0.95905396
73MP0005394_taste/olfaction_phenotype0.94509802
74MP0005499_abnormal_olfactory_system0.94509802
75MP0005395_other_phenotype0.93298431
76MP0005379_endocrine/exocrine_gland_phen0.91656269
77MP0004133_heterotaxia0.91489152
78MP0002837_dystrophic_cardiac_calcinosis0.87529461
79MP0004264_abnormal_extraembryonic_tissu0.86043633
80MP0002095_abnormal_skin_pigmentation0.85502246
81MP0004142_abnormal_muscle_tone0.83773767
82MP0002277_abnormal_respiratory_mucosa0.82275952
83MP0001873_stomach_inflammation0.81183100
84MP0005310_abnormal_salivary_gland0.80516515
85MP0001286_abnormal_eye_development0.78977425
86MP0002006_tumorigenesis0.77043347
87MP0002161_abnormal_fertility/fecundity0.74113616
88MP0009046_muscle_twitch0.73767557
89MP0002234_abnormal_pharynx_morphology0.70751065
90MP0002084_abnormal_developmental_patter0.70645345
91MP0005174_abnormal_tail_pigmentation0.69885855
92MP0003699_abnormal_female_reproductive0.66968858
93MP0005380_embryogenesis_phenotype0.66625852
94MP0001672_abnormal_embryogenesis/_devel0.66625852
95MP0001986_abnormal_taste_sensitivity0.66307968
96MP0002938_white_spotting0.66000670
97MP0009703_decreased_birth_body0.65270579
98MP0002638_abnormal_pupillary_reflex0.64832604
99MP0001486_abnormal_startle_reflex0.64814168
100MP0001501_abnormal_sleep_pattern0.64462702

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.42630592
2Colon cancer (HP:0003003)3.40487321
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34608530
4Pancreatic cysts (HP:0001737)3.13121477
5Abnormality of chromosome stability (HP:0003220)3.09081470
6Volvulus (HP:0002580)2.85103763
7Abnormality of the ileum (HP:0001549)2.80510943
8Aplasia/Hypoplasia of the uvula (HP:0010293)2.78332782
9Abnormality of the renal cortex (HP:0011035)2.76217110
10Meckel diverticulum (HP:0002245)2.68792225
11Pancreatic fibrosis (HP:0100732)2.68476915
12Abnormality of the labia minora (HP:0012880)2.68128515
13Nephroblastoma (Wilms tumor) (HP:0002667)2.67859817
14Attenuation of retinal blood vessels (HP:0007843)2.65548385
15Embryonal renal neoplasm (HP:0011794)2.51582661
16Chronic hepatic failure (HP:0100626)2.47291502
17Abnormality of the preputium (HP:0100587)2.40648610
18Abolished electroretinogram (ERG) (HP:0000550)2.37506091
19Clubbing of toes (HP:0100760)2.36251025
20Molar tooth sign on MRI (HP:0002419)2.33813380
21Abnormality of midbrain morphology (HP:0002418)2.33813380
22Renal cortical cysts (HP:0000803)2.31580014
23Abnormality of the pons (HP:0007361)2.26297236
24Protruding tongue (HP:0010808)2.25882208
25Congenital stationary night blindness (HP:0007642)2.23364087
26Abnormality of the renal medulla (HP:0100957)2.17503114
27Nephronophthisis (HP:0000090)2.15526372
28Pendular nystagmus (HP:0012043)2.15373919
29Progressive inability to walk (HP:0002505)2.15300847
30Medial flaring of the eyebrow (HP:0010747)2.14735985
31Duodenal stenosis (HP:0100867)2.13506313
32Small intestinal stenosis (HP:0012848)2.13506313
33Hypoplasia of the pons (HP:0012110)2.13116336
34True hermaphroditism (HP:0010459)2.06597224
35Sloping forehead (HP:0000340)2.06247113
36Gaze-evoked nystagmus (HP:0000640)2.05250493
37Thyroid-stimulating hormone excess (HP:0002925)2.03238918
38Neoplasm of the adrenal cortex (HP:0100641)2.02145201
39Stomach cancer (HP:0012126)2.00859562
40Intestinal atresia (HP:0011100)1.99197619
41Birth length less than 3rd percentile (HP:0003561)1.97359322
42Rhabdomyosarcoma (HP:0002859)1.95858743
433-Methylglutaconic aciduria (HP:0003535)1.95639187
44Inability to walk (HP:0002540)1.94336948
45Abnormality of the duodenum (HP:0002246)1.94295814
46Genital tract atresia (HP:0001827)1.93299396
47Optic nerve hypoplasia (HP:0000609)1.90714395
48Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88446319
49Acute necrotizing encephalopathy (HP:0006965)1.86471121
50Chronic bronchitis (HP:0004469)1.86298437
51Abnormal rod and cone electroretinograms (HP:0008323)1.86205604
52Vaginal atresia (HP:0000148)1.85909728
53Hyperventilation (HP:0002883)1.85577366
54Aplasia/Hypoplasia of the tibia (HP:0005772)1.82257467
55Tubulointerstitial nephritis (HP:0001970)1.82205127
56IgG deficiency (HP:0004315)1.82179670
57Nephrogenic diabetes insipidus (HP:0009806)1.81104109
58Median cleft lip (HP:0000161)1.80929629
59Acute encephalopathy (HP:0006846)1.80787141
60Supernumerary spleens (HP:0009799)1.80069036
61Tubular atrophy (HP:0000092)1.78517855
62Lipid accumulation in hepatocytes (HP:0006561)1.77665644
63Medulloblastoma (HP:0002885)1.76199386
64Type II lissencephaly (HP:0007260)1.76147816
65Broad-based gait (HP:0002136)1.75963523
66Fair hair (HP:0002286)1.75664325
67Septo-optic dysplasia (HP:0100842)1.75619150
68Triphalangeal thumb (HP:0001199)1.75454670
69Biliary tract neoplasm (HP:0100574)1.75239566
70Bilateral microphthalmos (HP:0007633)1.74677541
71Lissencephaly (HP:0001339)1.74670639
72Abnormal biliary tract physiology (HP:0012439)1.74340856
73Bile duct proliferation (HP:0001408)1.74340856
74Congenital primary aphakia (HP:0007707)1.74249739
75Breast carcinoma (HP:0003002)1.73750703
76Abnormal lung lobation (HP:0002101)1.73377456
77Abnormality of the renal collecting system (HP:0004742)1.72873574
78Aplastic anemia (HP:0001915)1.71166080
79Pancreatic islet-cell hyperplasia (HP:0004510)1.70765971
80Clitoromegaly (HP:0000057)1.70668110
81Hyperglycinemia (HP:0002154)1.70374867
82T lymphocytopenia (HP:0005403)1.70040779
83Cerebellar dysplasia (HP:0007033)1.69906820
84Duplicated collecting system (HP:0000081)1.68893392
85Progressive macrocephaly (HP:0004481)1.68477702
86Bony spicule pigmentary retinopathy (HP:0007737)1.68416626
87Poor coordination (HP:0002370)1.65591744
88Increased hepatocellular lipid droplets (HP:0006565)1.64884561
89Absent thumb (HP:0009777)1.64819444
90Abnormality of T cell number (HP:0011839)1.64680374
91Increased CSF lactate (HP:0002490)1.64244443
92Dandy-Walker malformation (HP:0001305)1.63125106
93Glioma (HP:0009733)1.62364570
94Abnormality of DNA repair (HP:0003254)1.62071961
95Myelodysplasia (HP:0002863)1.60925302
96Gait imbalance (HP:0002141)1.60580653
97Ependymoma (HP:0002888)1.60485074
98Methylmalonic acidemia (HP:0002912)1.60126792
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.60090351
100Hyperalaninemia (HP:0003348)1.60090351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.72117072
2ZAK3.40094398
3WNK32.85958851
4NUAK12.84451718
5INSRR2.39147752
6PLK42.38134433
7BRSK22.33277779
8EIF2AK32.25260403
9TAOK32.23181953
10LATS12.22845761
11BMPR1B2.13752616
12CDC72.09167359
13ACVR1B1.99826833
14ADRBK21.99652247
15STK38L1.98123027
16TSSK61.90076664
17MST41.88924051
18MKNK21.75956084
19TTK1.75781856
20TRIM281.65447983
21SRPK11.60668515
22MAP3K41.51190656
23PLK31.50716556
24MAP4K21.46402843
25NLK1.45265404
26GRK11.41789566
27TNIK1.40051847
28TXK1.37543589
29OXSR11.35592465
30TEC1.34358435
31STK391.31145037
32TLK11.29569093
33VRK11.26413134
34PASK1.23768508
35TAF11.22531594
36MKNK11.21137133
37PINK11.18984882
38BUB11.16596085
39STK31.13843990
40CDK191.13139586
41WNK41.06814850
42CASK1.05955929
43NME11.03220698
44PLK11.02070619
45BCR1.01115513
46NEK21.01047162
47WEE10.98315215
48ATR0.95498886
49DYRK30.94017384
50BRD40.92956204
51CSNK1G10.91108486
52PBK0.88684264
53PLK20.85580701
54ATM0.77805849
55VRK20.77155464
56ERBB40.73847887
57RPS6KA40.73357624
58DYRK20.72521139
59MAPK130.71028463
60PIM10.70873157
61CHEK20.70791182
62FLT30.67965174
63CDK30.67364662
64PNCK0.65903129
65MAP2K70.65528673
66TGFBR10.64534361
67CAMK1G0.64395286
68CSNK1A1L0.64217793
69CSNK1G20.61125639
70RPS6KA50.60719356
71CAMK1D0.57571980
72MAP4K10.57396933
73ITK0.57170183
74PRKCE0.56742191
75CAMKK20.56170062
76CSNK1G30.55054892
77ERBB30.52766148
78FGFR20.52354928
79AURKB0.52266324
80STK240.51815030
81MAP3K90.51409567
82PRKCQ0.48265792
83CHEK10.45360086
84SGK20.44255053
85AKT30.42543085
86FGFR10.42399411
87MARK30.41144785
88MUSK0.41115180
89CSNK1D0.40502425
90CSNK1E0.38491962
91NEK10.38304182
92CSNK1A10.36213237
93NEK60.35741469
94BTK0.35265066
95EGFR0.34458239
96TIE10.33953986
97PIK3CA0.32041442
98ADRBK10.31853230
99DYRK1A0.31046449
100CDK10.30907650

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.14951651
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03595167
3Basal transcription factors_Homo sapiens_hsa030222.80089790
4Fanconi anemia pathway_Homo sapiens_hsa034602.74449313
5Mismatch repair_Homo sapiens_hsa034302.65283654
6RNA degradation_Homo sapiens_hsa030182.61568613
7RNA polymerase_Homo sapiens_hsa030202.60271218
8Non-homologous end-joining_Homo sapiens_hsa034502.42627710
9Selenocompound metabolism_Homo sapiens_hsa004502.33547226
10RNA transport_Homo sapiens_hsa030132.20619471
11Proteasome_Homo sapiens_hsa030502.12313176
12Phototransduction_Homo sapiens_hsa047442.07388238
13DNA replication_Homo sapiens_hsa030302.05552507
14Protein export_Homo sapiens_hsa030601.88314048
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87811931
16One carbon pool by folate_Homo sapiens_hsa006701.78480244
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78380323
18Nucleotide excision repair_Homo sapiens_hsa034201.65486623
19Oxidative phosphorylation_Homo sapiens_hsa001901.56888793
20Ribosome_Homo sapiens_hsa030101.56335190
21Cell cycle_Homo sapiens_hsa041101.53155167
22Primary immunodeficiency_Homo sapiens_hsa053401.50976907
23Spliceosome_Homo sapiens_hsa030401.49557970
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48967451
25Linoleic acid metabolism_Homo sapiens_hsa005911.48840404
26Propanoate metabolism_Homo sapiens_hsa006401.48822170
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47321311
28Base excision repair_Homo sapiens_hsa034101.46824106
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43595902
30Ether lipid metabolism_Homo sapiens_hsa005651.42678954
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40973230
32mRNA surveillance pathway_Homo sapiens_hsa030151.38111808
33Nitrogen metabolism_Homo sapiens_hsa009101.35054108
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34918079
35Caffeine metabolism_Homo sapiens_hsa002321.28647337
36Olfactory transduction_Homo sapiens_hsa047401.28407039
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26273099
38Butanoate metabolism_Homo sapiens_hsa006501.24412423
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.23690669
40Parkinsons disease_Homo sapiens_hsa050121.18708108
41Taste transduction_Homo sapiens_hsa047421.18058612
42p53 signaling pathway_Homo sapiens_hsa041151.15172589
43Purine metabolism_Homo sapiens_hsa002301.09109169
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07313429
45Systemic lupus erythematosus_Homo sapiens_hsa053221.05585763
46Pyrimidine metabolism_Homo sapiens_hsa002401.04333513
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04069838
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00176273
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99033875
50Huntingtons disease_Homo sapiens_hsa050160.98429617
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97697173
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93653973
53Regulation of autophagy_Homo sapiens_hsa041400.93105621
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89900231
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.86284656
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.83827355
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82174179
58Type I diabetes mellitus_Homo sapiens_hsa049400.79316645
59Asthma_Homo sapiens_hsa053100.78469174
60Oocyte meiosis_Homo sapiens_hsa041140.77345146
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75630493
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.73537637
63Peroxisome_Homo sapiens_hsa041460.73444637
64Nicotine addiction_Homo sapiens_hsa050330.70255166
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67407140
66Autoimmune thyroid disease_Homo sapiens_hsa053200.67219126
67Allograft rejection_Homo sapiens_hsa053300.66532592
68Graft-versus-host disease_Homo sapiens_hsa053320.64333249
69Retinol metabolism_Homo sapiens_hsa008300.59185358
70Tryptophan metabolism_Homo sapiens_hsa003800.58065689
71Alzheimers disease_Homo sapiens_hsa050100.56866461
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56098616
73Alcoholism_Homo sapiens_hsa050340.54386456
74Metabolic pathways_Homo sapiens_hsa011000.53832658
75Ovarian steroidogenesis_Homo sapiens_hsa049130.52978949
76Chemical carcinogenesis_Homo sapiens_hsa052040.51900184
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49800082
78Steroid biosynthesis_Homo sapiens_hsa001000.49416528
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47871003
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46773783
81Antigen processing and presentation_Homo sapiens_hsa046120.46371706
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45223420
83Vitamin digestion and absorption_Homo sapiens_hsa049770.44403417
84T cell receptor signaling pathway_Homo sapiens_hsa046600.39617817
85TGF-beta signaling pathway_Homo sapiens_hsa043500.39000295
86Dorso-ventral axis formation_Homo sapiens_hsa043200.38964149
87Arachidonic acid metabolism_Homo sapiens_hsa005900.38262587
88Circadian rhythm_Homo sapiens_hsa047100.37229324
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37218406
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35690720
91ABC transporters_Homo sapiens_hsa020100.35237800
92Fatty acid biosynthesis_Homo sapiens_hsa000610.33995033
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31836356
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.31484074
95Hematopoietic cell lineage_Homo sapiens_hsa046400.31193442
96Fat digestion and absorption_Homo sapiens_hsa049750.30838141
97Serotonergic synapse_Homo sapiens_hsa047260.28846245
98Lysine degradation_Homo sapiens_hsa003100.28589074
99Epstein-Barr virus infection_Homo sapiens_hsa051690.25930372
100Viral carcinogenesis_Homo sapiens_hsa052030.24549091

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