ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.56187289
2	fucose catabolic process (GO:0019317)	4.44184729
3	L-fucose metabolic process (GO:0042354)	4.44184729
4	L-fucose catabolic process (GO:0042355)	4.44184729
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.07026746
6	response to pheromone (GO:0019236)	3.83364610
7	tryptophan catabolic process (GO:0006569)	3.77717145
8	indole-containing compound catabolic process (GO:0042436)	3.77717145
9	indolalkylamine catabolic process (GO:0046218)	3.77717145
10	indolalkylamine metabolic process (GO:0006586)	3.77208384
11	DNA deamination (GO:0045006)	3.73214382
12	kynurenine metabolic process (GO:0070189)	3.71268286
13	gamma-aminobutyric acid transport (GO:0015812)	3.68119902
14	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.57026618
15	water-soluble vitamin biosynthetic process (GO:0042364)	3.44046670
16	pyrimidine nucleobase catabolic process (GO:0006208)	3.42204350
17	protein polyglutamylation (GO:0018095)	3.40751406
18	sulfation (GO:0051923)	3.35725735
19	regulation of cilium movement (GO:0003352)	3.33119964
20	tryptophan metabolic process (GO:0006568)	3.26225991
21	negative regulation of mast cell activation (GO:0033004)	3.25257845
22	neuronal action potential (GO:0019228)	3.22217597
23	neural tube formation (GO:0001841)	3.18175245
24	nonmotile primary cilium assembly (GO:0035058)	3.16874499
25	detection of light stimulus involved in sensory perception (GO:0050962)	3.14719518
26	detection of light stimulus involved in visual perception (GO:0050908)	3.14719518
27	platelet dense granule organization (GO:0060155)	3.08266678
28	indole-containing compound metabolic process (GO:0042430)	3.07551840
29	cellular ketone body metabolic process (GO:0046950)	3.04057278
30	cornea development in camera-type eye (GO:0061303)	3.03778023
31	kidney morphogenesis (GO:0060993)	3.03257700
32	epithelial cilium movement (GO:0003351)	3.01036860
33	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.91474576
34	axoneme assembly (GO:0035082)	2.90219737
35	somite development (GO:0061053)	2.90104856
36	transmission of nerve impulse (GO:0019226)	2.89939740
37	reflex (GO:0060004)	2.89453775
38	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.87326688
39	nucleobase catabolic process (GO:0046113)	2.86891309
40	serotonin metabolic process (GO:0042428)	2.86291271
41	cilium morphogenesis (GO:0060271)	2.85861234
42	ketone body metabolic process (GO:1902224)	2.83448502
43	primary amino compound metabolic process (GO:1901160)	2.82232532
44	regulation of action potential (GO:0098900)	2.79996167
45	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.78962567
46	NADH dehydrogenase complex assembly (GO:0010257)	2.78962567
47	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.78962567
48	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.78687381
49	piRNA metabolic process (GO:0034587)	2.78179376
50	photoreceptor cell development (GO:0042461)	2.75464763
51	protein-cofactor linkage (GO:0018065)	2.74780209
52	preassembly of GPI anchor in ER membrane (GO:0016254)	2.70542552
53	behavioral response to ethanol (GO:0048149)	2.70384229
54	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.70231923
55	cell proliferation in forebrain (GO:0021846)	2.67048093
56	negative regulation of telomere maintenance (GO:0032205)	2.64255563
57	spinal cord motor neuron differentiation (GO:0021522)	2.63787565
58	photoreceptor cell maintenance (GO:0045494)	2.63534382
59	protein complex biogenesis (GO:0070271)	2.62030343
60	protein K11-linked deubiquitination (GO:0035871)	2.61571338
61	rhodopsin mediated signaling pathway (GO:0016056)	2.60173983
62	retinal cone cell development (GO:0046549)	2.59868813
63	reciprocal meiotic recombination (GO:0007131)	2.59596274
64	reciprocal DNA recombination (GO:0035825)	2.59596274
65	recombinational repair (GO:0000725)	2.59124749
66	startle response (GO:0001964)	2.58897931
67	presynaptic membrane assembly (GO:0097105)	2.58284550
68	double-strand break repair via homologous recombination (GO:0000724)	2.58097622
69	cAMP catabolic process (GO:0006198)	2.57008898
70	cilium organization (GO:0044782)	2.56867581
71	dopamine transport (GO:0015872)	2.55787749
72	cellular response to ATP (GO:0071318)	2.55449055
73	negative regulation of systemic arterial blood pressure (GO:0003085)	2.54909532
74	membrane depolarization during action potential (GO:0086010)	2.54328846
75	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.52128088
76	otic vesicle formation (GO:0030916)	2.51879439
77	regulation of hexokinase activity (GO:1903299)	2.51581696
78	regulation of glucokinase activity (GO:0033131)	2.51581696
79	cilium assembly (GO:0042384)	2.50905992
80	protein localization to cilium (GO:0061512)	2.50212452
81	amine catabolic process (GO:0009310)	2.49591307
82	cellular biogenic amine catabolic process (GO:0042402)	2.49591307
83	ubiquinone biosynthetic process (GO:0006744)	2.48898496
84	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.48881680
85	eye photoreceptor cell development (GO:0042462)	2.48806785
86	regulation of hippo signaling (GO:0035330)	2.48744482
87	tachykinin receptor signaling pathway (GO:0007217)	2.47052000
88	synaptic transmission, cholinergic (GO:0007271)	2.46712018
89	replication fork processing (GO:0031297)	2.45568573
90	cilium movement (GO:0003341)	2.45402913
91	mitochondrial respiratory chain complex assembly (GO:0033108)	2.43699087
92	regulation of mesoderm development (GO:2000380)	2.43489244
93	adaptation of signaling pathway (GO:0023058)	2.43311757
94	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.42586387
95	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.42533109
96	ubiquinone metabolic process (GO:0006743)	2.41292869
97	embryonic epithelial tube formation (GO:0001838)	2.38684956
98	action potential (GO:0001508)	2.38611905
99	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.38220186
100	regulation of microtubule-based movement (GO:0060632)	2.36903376

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.81263273
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.30068867
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.20508889
4	VDR_22108803_ChIP-Seq_LS180_Human	2.96063482
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.92622243
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.90514901
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.73727546
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.46732342
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.37479403
10	FUS_26573619_Chip-Seq_HEK293_Human	2.28985604
11	EWS_26573619_Chip-Seq_HEK293_Human	2.28498036
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26652561
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.16538447
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.15281009
15	P300_19829295_ChIP-Seq_ESCs_Human	2.07069072
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.06868976
17	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.04749907
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.90411408
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.83743537
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.80817771
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.78134422
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.72503176
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.66293849
24	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.66122359
25	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.65869715
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.63567705
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63462263
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62786224
29	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62726252
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62663323
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.61125938
32	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.60992021
33	STAT3_23295773_ChIP-Seq_U87_Human	1.59414438
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.59326925
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56724420
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.56208258
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.54275633
38	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.54087707
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49056711
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.49056711
41	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48473252
42	AR_25329375_ChIP-Seq_VCAP_Human	1.46653275
43	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.45445704
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.44856146
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44655193
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44655193
47	TCF4_23295773_ChIP-Seq_U87_Human	1.44593783
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.44520500
49	REST_21632747_ChIP-Seq_MESCs_Mouse	1.44369218
50	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43372557
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.41008019
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36227183
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35950851
54	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.34298348
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.33937878
56	RNF2_27304074_Chip-Seq_NSC_Mouse	1.33663037
57	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28267402
58	AR_21572438_ChIP-Seq_LNCaP_Human	1.27204950
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26693680
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25453003
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25453003
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24313857
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.24040761
64	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.23113536
65	* TCF4_22108803_ChIP-Seq_LS180_Human	1.22493862
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22309350
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22305557
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21964306
69	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20817635
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.20278712
71	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19107405
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19107405
73	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17422879
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16399474
75	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.12982311
76	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.12765877
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11808529
78	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.11575726
79	NCOR_22424771_ChIP-Seq_293T_Human	1.11080484
80	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.10989615
81	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.10446609
82	* SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10115828
83	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.10059733
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09951760
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08521310
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07661054
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07350408
88	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.07091852
89	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.06398091
90	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04961910
91	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04892430
92	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.03508342
93	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01967975
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01620515
95	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01514920
96	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01297670
97	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99443033
98	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97747112
99	AR_20517297_ChIP-Seq_VCAP_Human	0.96894877
100	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.96800373

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	2.76644896
2	MP0002102_abnormal_ear_morphology	2.66446881
3	MP0003195_calcinosis	2.60035622
4	MP0003646_muscle_fatigue	2.55096781
5	MP0008877_abnormal_DNA_methylation	2.52966656
6	MP0002837_dystrophic_cardiac_calcinosis	2.52248018
7	MP0003136_yellow_coat_color	2.51907609
8	MP0005551_abnormal_eye_electrophysiolog	2.44439163
9	MP0001968_abnormal_touch/_nociception	2.34652628
10	MP0004885_abnormal_endolymph	2.22170014
11	MP0000569_abnormal_digit_pigmentation	2.16812399
12	MP0002638_abnormal_pupillary_reflex	2.06606673
13	MP0009046_muscle_twitch	2.06117333
14	MP0002736_abnormal_nociception_after	2.04548848
15	MP0003787_abnormal_imprinting	2.00005939
16	MP0006072_abnormal_retinal_apoptosis	1.99546490
17	MP0000372_irregular_coat_pigmentation	1.97912518
18	MP0004142_abnormal_muscle_tone	1.97871431
19	MP0009745_abnormal_behavioral_response	1.96509798
20	MP0002272_abnormal_nervous_system	1.82758298
21	MP0001986_abnormal_taste_sensitivity	1.80928104
22	MP0005646_abnormal_pituitary_gland	1.79205703
23	MP0008872_abnormal_physiological_respon	1.75698922
24	MP0001485_abnormal_pinna_reflex	1.70126809
25	MP0005253_abnormal_eye_physiology	1.67263742
26	MP0002735_abnormal_chemical_nociception	1.66900457
27	MP0004145_abnormal_muscle_electrophysio	1.66171632
28	MP0006276_abnormal_autonomic_nervous	1.64895005
29	MP0000631_abnormal_neuroendocrine_gland	1.62679588
30	MP0002653_abnormal_ependyma_morphology	1.57300071
31	MP0002876_abnormal_thyroid_physiology	1.54896376
32	MP0005174_abnormal_tail_pigmentation	1.54741023
33	MP0003880_abnormal_central_pattern	1.54054302
34	MP0008875_abnormal_xenobiotic_pharmacok	1.52756790
35	MP0004133_heterotaxia	1.50983295
36	MP0005645_abnormal_hypothalamus_physiol	1.50149243
37	MP0001501_abnormal_sleep_pattern	1.47484679
38	MP0001486_abnormal_startle_reflex	1.47483799
39	MP0002938_white_spotting	1.46677499
40	MP0000427_abnormal_hair_cycle	1.42983290
41	MP0004742_abnormal_vestibular_system	1.39380939
42	MP0001984_abnormal_olfaction	1.38371774
43	MP0002572_abnormal_emotion/affect_behav	1.37731601
44	MP0002064_seizures	1.35801266
45	MP0001970_abnormal_pain_threshold	1.34537216
46	MP0002160_abnormal_reproductive_system	1.33790597
47	MP0005084_abnormal_gallbladder_morpholo	1.31987491
48	MP0002733_abnormal_thermal_nociception	1.31001755
49	MP0002557_abnormal_social/conspecific_i	1.29018769
50	MP0002138_abnormal_hepatobiliary_system	1.27862157
51	MP0001529_abnormal_vocalization	1.27718550
52	MP0004147_increased_porphyrin_level	1.24298845
53	MP0000778_abnormal_nervous_system	1.23110536
54	MP0003635_abnormal_synaptic_transmissio	1.22714927
55	MP0005389_reproductive_system_phenotype	1.22375181
56	MP0002234_abnormal_pharynx_morphology	1.21050720
57	MP0002067_abnormal_sensory_capabilities	1.20838023
58	MP0002928_abnormal_bile_duct	1.20445633
59	MP0002734_abnormal_mechanical_nocicepti	1.20301530
60	MP0005386_behavior/neurological_phenoty	1.16954179
61	MP0004924_abnormal_behavior	1.16954179
62	MP0004043_abnormal_pH_regulation	1.15789141
63	MP0002063_abnormal_learning/memory/cond	1.14469200
64	MP0002095_abnormal_skin_pigmentation	1.12919515
65	MP0010386_abnormal_urinary_bladder	1.11983966
66	MP0005423_abnormal_somatic_nervous	1.10866547
67	MP0005195_abnormal_posterior_eye	1.09677765
68	MP0002277_abnormal_respiratory_mucosa	1.07641181
69	MP0003011_delayed_dark_adaptation	1.06444665
70	MP0002163_abnormal_gland_morphology	1.04962162
71	MP0002752_abnormal_somatic_nervous	0.99297003
72	MP0003718_maternal_effect	0.96010515
73	MP0000026_abnormal_inner_ear	0.95532189
74	MP0004215_abnormal_myocardial_fiber	0.95110032
75	MP0003283_abnormal_digestive_organ	0.94733797
76	MP0002751_abnormal_autonomic_nervous	0.94661509
77	MP0008058_abnormal_DNA_repair	0.90357740
78	MP0000230_abnormal_systemic_arterial	0.87863389
79	MP0002184_abnormal_innervation	0.87431252
80	MP0001963_abnormal_hearing_physiology	0.87323969
81	MP0001919_abnormal_reproductive_system	0.86873609
82	MP0005075_abnormal_melanosome_morpholog	0.86798599
83	MP0005379_endocrine/exocrine_gland_phen	0.85519212
84	MP0001905_abnormal_dopamine_level	0.85431446
85	MP0000049_abnormal_middle_ear	0.82586991
86	MP0000383_abnormal_hair_follicle	0.82480926
87	MP0001324_abnormal_eye_pigmentation	0.82462083
88	MP0003890_abnormal_embryonic-extraembry	0.82107735
89	MP0000955_abnormal_spinal_cord	0.82103255
90	MP0002229_neurodegeneration	0.81420278
91	MP0005171_absent_coat_pigmentation	0.80840826
92	MP0003119_abnormal_digestive_system	0.80818575
93	MP0003937_abnormal_limbs/digits/tail_de	0.80466052
94	MP0008775_abnormal_heart_ventricle	0.79049257
95	MP0003137_abnormal_impulse_conducting	0.77939967
96	MP0005410_abnormal_fertilization	0.77688722
97	MP0003121_genomic_imprinting	0.76040013
98	MP0003698_abnormal_male_reproductive	0.75385237
99	MP0005187_abnormal_penis_morphology	0.73376436
100	MP0001293_anophthalmia	0.73141356

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.80370182
2	Pancreatic fibrosis (HP:0100732)	4.33753198
3	Molar tooth sign on MRI (HP:0002419)	4.25753716
4	Abnormality of midbrain morphology (HP:0002418)	4.25753716
5	Congenital stationary night blindness (HP:0007642)	4.24620328
6	True hermaphroditism (HP:0010459)	4.21935957
7	Nephronophthisis (HP:0000090)	3.86608292
8	Abnormality of the renal cortex (HP:0011035)	3.38449580
9	Abnormality of the renal medulla (HP:0100957)	3.36520478
10	Hyperventilation (HP:0002883)	3.13345390
11	Pendular nystagmus (HP:0012043)	3.06690849
12	Medial flaring of the eyebrow (HP:0010747)	2.98280990
13	Cystic liver disease (HP:0006706)	2.91970722
14	Abolished electroretinogram (ERG) (HP:0000550)	2.87670682
15	Attenuation of retinal blood vessels (HP:0007843)	2.87450030
16	Progressive cerebellar ataxia (HP:0002073)	2.77720840
17	Chronic hepatic failure (HP:0100626)	2.77593039
18	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.73810715
19	Abnormality of alanine metabolism (HP:0010916)	2.73810715
20	Hyperalaninemia (HP:0003348)	2.73810715
21	Genetic anticipation (HP:0003743)	2.65417336
22	Type II lissencephaly (HP:0007260)	2.65270097
23	Inability to walk (HP:0002540)	2.62406100
24	Tubular atrophy (HP:0000092)	2.60387083
25	Gaze-evoked nystagmus (HP:0000640)	2.60219900
26	Progressive inability to walk (HP:0002505)	2.57244341
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.55952005
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.54614059
29	Absent/shortened dynein arms (HP:0200106)	2.54614059
30	Renal cortical cysts (HP:0000803)	2.51742898
31	Decreased central vision (HP:0007663)	2.50807752
32	Gait imbalance (HP:0002141)	2.49019871
33	Furrowed tongue (HP:0000221)	2.45965530
34	Abnormal drinking behavior (HP:0030082)	2.44155669
35	Polydipsia (HP:0001959)	2.44155669
36	Sclerocornea (HP:0000647)	2.41963767
37	Increased corneal curvature (HP:0100692)	2.41080323
38	Keratoconus (HP:0000563)	2.41080323
39	Congenital primary aphakia (HP:0007707)	2.37507031
40	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.29186304
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.26988151
42	Congenital hepatic fibrosis (HP:0002612)	2.25506300
43	Anencephaly (HP:0002323)	2.23863256
44	Bile duct proliferation (HP:0001408)	2.23443538
45	Abnormal biliary tract physiology (HP:0012439)	2.23443538
46	Lissencephaly (HP:0001339)	2.22717899
47	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.20441213
48	Broad-based gait (HP:0002136)	2.19502987
49	Chorioretinal atrophy (HP:0000533)	2.19491734
50	Bony spicule pigmentary retinopathy (HP:0007737)	2.18078956
51	Nephrogenic diabetes insipidus (HP:0009806)	2.17781307
52	Large for gestational age (HP:0001520)	2.17108894
53	Congenital, generalized hypertrichosis (HP:0004540)	2.16553623
54	Abnormal respiratory epithelium morphology (HP:0012253)	2.13312993
55	Abnormal respiratory motile cilium morphology (HP:0005938)	2.13312993
56	Genital tract atresia (HP:0001827)	2.13040398
57	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.09342606
58	Male pseudohermaphroditism (HP:0000037)	2.09115298
59	Vaginal atresia (HP:0000148)	2.07543925
60	Methylmalonic acidemia (HP:0002912)	2.07199893
61	Hemiparesis (HP:0001269)	2.06849726
62	Optic nerve hypoplasia (HP:0000609)	2.06749707
63	Febrile seizures (HP:0002373)	2.05587434
64	Congenital sensorineural hearing impairment (HP:0008527)	2.03849617
65	Polyuria (HP:0000103)	2.03140942
66	Aplasia/Hypoplasia of the patella (HP:0006498)	2.02001277
67	Patellar aplasia (HP:0006443)	2.01010163
68	Stomach cancer (HP:0012126)	2.00885453
69	Protruding tongue (HP:0010808)	1.96741731
70	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.92497420
71	Abnormal ciliary motility (HP:0012262)	1.88606613
72	Concave nail (HP:0001598)	1.86442230
73	Methylmalonic aciduria (HP:0012120)	1.85873519
74	Focal motor seizures (HP:0011153)	1.85644161
75	Pachygyria (HP:0001302)	1.84214366
76	Decreased circulating renin level (HP:0003351)	1.82871072
77	Postaxial foot polydactyly (HP:0001830)	1.82533952
78	Hypothermia (HP:0002045)	1.82214304
79	3-Methylglutaconic aciduria (HP:0003535)	1.79545966
80	Cerebellar dysplasia (HP:0007033)	1.78554924
81	Tachypnea (HP:0002789)	1.77102033
82	Small hand (HP:0200055)	1.76776321
83	Poor coordination (HP:0002370)	1.75042136
84	Increased CSF lactate (HP:0002490)	1.73728915
85	Abnormality of the labia minora (HP:0012880)	1.72942197
86	Acute necrotizing encephalopathy (HP:0006965)	1.72241233
87	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.72205151
88	Clumsiness (HP:0002312)	1.72183040
89	Fair hair (HP:0002286)	1.71960029
90	Astigmatism (HP:0000483)	1.69187109
91	Focal seizures (HP:0007359)	1.67427710
92	Mitochondrial inheritance (HP:0001427)	1.66795387
93	Ketoacidosis (HP:0001993)	1.66138399
94	Postaxial hand polydactyly (HP:0001162)	1.64403419
95	Intestinal atresia (HP:0011100)	1.64291156
96	Severe muscular hypotonia (HP:0006829)	1.64205485
97	Progressive macrocephaly (HP:0004481)	1.62856488
98	Optic disc pallor (HP:0000543)	1.62629848
99	Birth length less than 3rd percentile (HP:0003561)	1.62246794
100	Short tibia (HP:0005736)	1.62237056

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.07012338
2	ADRBK2	3.19639486
3	BMPR1B	3.08688632
4	TAOK3	2.80337842
5	MAP4K2	2.68972035
6	ACVR1B	2.47010273
7	GRK1	2.46166592
8	CASK	2.37335460
9	MAPK13	2.29518761
10	ZAK	2.27490901
11	TLK1	2.26336288
12	WNK3	2.20304514
13	NUAK1	2.18575225
14	PINK1	1.98274693
15	MARK1	1.81244947
16	WNK4	1.75595612
17	INSRR	1.73194122
18	MAP3K4	1.71831606
19	PNCK	1.67531175
20	OXSR1	1.29435821
21	TXK	1.26443344
22	DAPK2	1.24965423
23	STK39	1.21961109
24	ADRBK1	1.19137217
25	DYRK2	1.16650761
26	MKNK2	1.11690703
27	TNIK	1.08911120
28	CAMKK2	1.06816013
29	PAK3	1.04789073
30	TGFBR1	1.02060828
31	PRKCG	1.01839735
32	PHKG1	0.95643826
33	PHKG2	0.95643826
34	TIE1	0.94862533
35	PLK2	0.94561670
36	MAP2K7	0.92615513
37	PRKCE	0.90947944
38	TRIM28	0.85581142
39	NEK1	0.85362283
40	CSNK1G2	0.84594951
41	BRSK2	0.83656015
42	FGFR2	0.81839156
43	PLK4	0.80148058
44	STK38L	0.78640895
45	MAPK15	0.77981142
46	PIK3CA	0.77958860
47	VRK1	0.77244688
48	NTRK2	0.76797798
49	NTRK3	0.74699120
50	MUSK	0.74239188
51	NEK2	0.74046275
52	TEC	0.73842265
53	PKN1	0.73623079
54	STK16	0.72990086
55	CSNK1G1	0.71309283
56	EPHA3	0.69511172
57	BCKDK	0.68253482
58	BCR	0.67409518
59	OBSCN	0.67368067
60	MAP2K6	0.67135650
61	IKBKB	0.65649453
62	CSNK1G3	0.64866787
63	WEE1	0.61545733
64	CAMK2A	0.60562022
65	PRKCQ	0.59985342
66	SIK2	0.58230009
67	PTK2B	0.57345231
68	GRK7	0.54874209
69	MAPKAPK5	0.53641826
70	CSNK1A1L	0.52258220
71	MAPKAPK3	0.51351997
72	RPS6KA5	0.49710740
73	ERBB3	0.48545503
74	CDK3	0.48054484
75	STK3	0.47871654
76	PRKACA	0.47786175
77	KIT	0.46614230
78	GRK5	0.44333442
79	EPHA4	0.44297027
80	PLK3	0.43712518
81	ITK	0.42439851
82	CSNK1A1	0.42177758
83	STK11	0.41861519
84	PRKCZ	0.40658960
85	CHUK	0.40310094
86	CSNK1D	0.39870644
87	MARK3	0.38704723
88	TNK2	0.38213057
89	CAMK1	0.36576212
90	MKNK1	0.35801426
91	ERBB2	0.34080437
92	SGK2	0.32394447
93	IRAK1	0.31934604
94	PRKG1	0.31831260
95	PRKCA	0.31598229
96	CHEK2	0.30917728
97	MAP2K4	0.30854593
98	PRKCI	0.30090905
99	FLT3	0.29084486
100	TAF1	0.28989427

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.94606973
2	Nitrogen metabolism_Homo sapiens_hsa00910	2.45843065
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.44858308
4	Nicotine addiction_Homo sapiens_hsa05033	2.41142663
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.36326841
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.33104127
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.29184557
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.22880034
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.17591965
10	Butanoate metabolism_Homo sapiens_hsa00650	2.16247047
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.15800063
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.12957876
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.11372031
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.08084061
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.98351855
16	Homologous recombination_Homo sapiens_hsa03440	1.97749242
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.89370254
18	RNA polymerase_Homo sapiens_hsa03020	1.88263892
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.79168995
20	Protein export_Homo sapiens_hsa03060	1.74087446
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.66239209
22	Taste transduction_Homo sapiens_hsa04742	1.62336500
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.59319068
24	Morphine addiction_Homo sapiens_hsa05032	1.52296439
25	Basal transcription factors_Homo sapiens_hsa03022	1.51722854
26	Caffeine metabolism_Homo sapiens_hsa00232	1.51078138
27	Parkinsons disease_Homo sapiens_hsa05012	1.43625750
28	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.43336222
29	Olfactory transduction_Homo sapiens_hsa04740	1.41808921
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.38083278
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.30986233
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30565589
33	Propanoate metabolism_Homo sapiens_hsa00640	1.26061562
34	RNA degradation_Homo sapiens_hsa03018	1.20716351
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.20527706
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.12012251
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.10890484
38	GABAergic synapse_Homo sapiens_hsa04727	1.08945366
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06790696
40	Circadian entrainment_Homo sapiens_hsa04713	1.06487934
41	Insulin secretion_Homo sapiens_hsa04911	1.04943833
42	Glutamatergic synapse_Homo sapiens_hsa04724	1.03049842
43	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.02783803
44	Serotonergic synapse_Homo sapiens_hsa04726	1.01186279
45	Cardiac muscle contraction_Homo sapiens_hsa04260	1.00558851
46	ABC transporters_Homo sapiens_hsa02010	1.00018651
47	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.99875532
48	Huntingtons disease_Homo sapiens_hsa05016	0.95762226
49	Retinol metabolism_Homo sapiens_hsa00830	0.95238698
50	Asthma_Homo sapiens_hsa05310	0.94038286
51	One carbon pool by folate_Homo sapiens_hsa00670	0.93164017
52	Peroxisome_Homo sapiens_hsa04146	0.91912021
53	Alzheimers disease_Homo sapiens_hsa05010	0.88307515
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.85896705
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82112024
56	Non-homologous end-joining_Homo sapiens_hsa03450	0.80802775
57	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.80197293
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.77262374
59	Regulation of autophagy_Homo sapiens_hsa04140	0.76649237
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.75895108
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.74381942
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74020492
63	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.73133485
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71293764
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70778322
66	Sulfur metabolism_Homo sapiens_hsa00920	0.70324046
67	Purine metabolism_Homo sapiens_hsa00230	0.68382898
68	Salivary secretion_Homo sapiens_hsa04970	0.67148326
69	Primary immunodeficiency_Homo sapiens_hsa05340	0.66868305
70	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.65695590
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62946886
72	Histidine metabolism_Homo sapiens_hsa00340	0.62266822
73	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.61242094
74	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.61177230
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59287916
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.57047060
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56696023
78	Type I diabetes mellitus_Homo sapiens_hsa04940	0.56627252
79	Dopaminergic synapse_Homo sapiens_hsa04728	0.55255538
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.51659329
81	Cocaine addiction_Homo sapiens_hsa05030	0.51564335
82	Cholinergic synapse_Homo sapiens_hsa04725	0.50356900
83	Metabolic pathways_Homo sapiens_hsa01100	0.49551936
84	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.49133016
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.48781753
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.47351437
87	Long-term depression_Homo sapiens_hsa04730	0.46801632
88	Graft-versus-host disease_Homo sapiens_hsa05332	0.45416551
89	Circadian rhythm_Homo sapiens_hsa04710	0.43326457
90	Allograft rejection_Homo sapiens_hsa05330	0.42130005
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.41004658
92	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.40019503
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39976092
94	Mineral absorption_Homo sapiens_hsa04978	0.39362342
95	Amphetamine addiction_Homo sapiens_hsa05031	0.39322822
96	cAMP signaling pathway_Homo sapiens_hsa04024	0.38586899
97	Sulfur relay system_Homo sapiens_hsa04122	0.38166889
98	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.37777553
99	Fatty acid degradation_Homo sapiens_hsa00071	0.34373432
100	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.32698513

ZNF527

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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