ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.73274694
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.55198436
3	indole-containing compound catabolic process (GO:0042436)	4.04634280
4	indolalkylamine catabolic process (GO:0046218)	4.04634280
5	tryptophan catabolic process (GO:0006569)	4.04634280
6	preassembly of GPI anchor in ER membrane (GO:0016254)	3.68770350
7	fucose catabolic process (GO:0019317)	3.62336055
8	L-fucose metabolic process (GO:0042354)	3.62336055
9	L-fucose catabolic process (GO:0042355)	3.62336055
10	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.58196198
11	response to lipoprotein particle (GO:0055094)	3.56017714
12	nephron tubule morphogenesis (GO:0072078)	3.49030801
13	nephron epithelium morphogenesis (GO:0072088)	3.49030801
14	kynurenine metabolic process (GO:0070189)	3.45525953
15	indolalkylamine metabolic process (GO:0006586)	3.43140735
16	neural tube formation (GO:0001841)	3.42914941
17	negative regulation of telomere maintenance (GO:0032205)	3.41135192
18	tryptophan metabolic process (GO:0006568)	3.32801759
19	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.30600105
20	reflex (GO:0060004)	3.27663371
21	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.20742878
22	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.20742878
23	regulation of translation, ncRNA-mediated (GO:0045974)	3.20742878
24	artery development (GO:0060840)	3.20276488
25	regulation of action potential (GO:0098900)	3.18532047
26	renal tubule morphogenesis (GO:0061333)	3.16472445
27	response to pheromone (GO:0019236)	3.06576421
28	somite development (GO:0061053)	3.06233518
29	kidney morphogenesis (GO:0060993)	3.03722947
30	epithelial cilium movement (GO:0003351)	3.03049022
31	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.01954189
32	negative regulation of mast cell activation (GO:0033004)	3.01903000
33	auditory behavior (GO:0031223)	3.00086992
34	sulfation (GO:0051923)	2.99888136
35	dendritic spine morphogenesis (GO:0060997)	2.98315067
36	interkinetic nuclear migration (GO:0022027)	2.91748571
37	presynaptic membrane assembly (GO:0097105)	2.84056878
38	cellular response to ethanol (GO:0071361)	2.82568131
39	hindbrain development (GO:0030902)	2.82142671
40	regulation of telomere maintenance (GO:0032204)	2.78666287
41	regulation of hippo signaling (GO:0035330)	2.78057726
42	positive regulation of vesicle fusion (GO:0031340)	2.73540582
43	presynaptic membrane organization (GO:0097090)	2.72243516
44	activated T cell proliferation (GO:0050798)	2.68299377
45	neuronal action potential (GO:0019228)	2.67006143
46	otic vesicle formation (GO:0030916)	2.66902301
47	regulation of timing of cell differentiation (GO:0048505)	2.66879691
48	cilium movement (GO:0003341)	2.66062561
49	photoreceptor cell maintenance (GO:0045494)	2.64548890
50	limb bud formation (GO:0060174)	2.62744136
51	protein K11-linked deubiquitination (GO:0035871)	2.60092830
52	multicellular organism reproduction (GO:0032504)	2.59229429
53	positive regulation of action potential (GO:0045760)	2.58620017
54	axoneme assembly (GO:0035082)	2.57765405
55	indole-containing compound metabolic process (GO:0042430)	2.57354887
56	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.55960001
57	cilium or flagellum-dependent cell motility (GO:0001539)	2.55430815
58	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.54693682
59	protein polyglutamylation (GO:0018095)	2.53693321
60	positive regulation of male gonad development (GO:2000020)	2.52509508
61	adaptation of signaling pathway (GO:0023058)	2.51303443
62	forebrain neuron differentiation (GO:0021879)	2.49779928
63	benzene-containing compound metabolic process (GO:0042537)	2.48551480
64	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.46027638
65	amine catabolic process (GO:0009310)	2.45973292
66	cellular biogenic amine catabolic process (GO:0042402)	2.45973292
67	forebrain morphogenesis (GO:0048853)	2.45613897
68	cilium morphogenesis (GO:0060271)	2.45151134
69	regulation of cilium movement (GO:0003352)	2.45065603
70	nonmotile primary cilium assembly (GO:0035058)	2.44385657
71	platelet dense granule organization (GO:0060155)	2.43142453
72	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.43048078
73	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.42872616
74	cAMP catabolic process (GO:0006198)	2.42783566
75	smoothened signaling pathway (GO:0007224)	2.42779437
76	neurotransmitter-gated ion channel clustering (GO:0072578)	2.42700795
77	membrane depolarization during action potential (GO:0086010)	2.42277601
78	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.42151678
79	smooth muscle contraction (GO:0006939)	2.41390110
80	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.40907707
81	inner ear receptor stereocilium organization (GO:0060122)	2.40375564
82	regulation of male gonad development (GO:2000018)	2.39779144
83	regulation of female gonad development (GO:2000194)	2.39641475
84	DNA deamination (GO:0045006)	2.38879579
85	cilium organization (GO:0044782)	2.38365103
86	negative regulation of astrocyte differentiation (GO:0048712)	2.37356678
87	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.37079041
88	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.35783244
89	prostate gland growth (GO:0060736)	2.35119224
90	mechanosensory behavior (GO:0007638)	2.34722166
91	spinal cord motor neuron differentiation (GO:0021522)	2.34588421
92	protein import into peroxisome matrix (GO:0016558)	2.33828109
93	regulation of collateral sprouting (GO:0048670)	2.31474729
94	cyclic nucleotide catabolic process (GO:0009214)	2.31462732
95	gamma-aminobutyric acid transport (GO:0015812)	2.30649704
96	piRNA metabolic process (GO:0034587)	2.29073866
97	negative regulation of systemic arterial blood pressure (GO:0003085)	2.26734435
98	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.26556447
99	embryonic epithelial tube formation (GO:0001838)	2.25030662
100	cellular response to exogenous dsRNA (GO:0071360)	2.24459109

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.50216601
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.44214266
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.06187647
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.87502148
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.75458860
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.59404853
7	VDR_22108803_ChIP-Seq_LS180_Human	2.54103356
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.48197158
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.41800236
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.37543048
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.27601219
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20161542
13	P300_19829295_ChIP-Seq_ESCs_Human	2.05119633
14	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.01724969
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97791151
16	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.94103523
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.92944320
18	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.84301728
19	BCAT_22108803_ChIP-Seq_LS180_Human	1.84272433
20	FUS_26573619_Chip-Seq_HEK293_Human	1.82953335
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.82596915
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80168176
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.77796277
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.77712223
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.77596483
26	AR_21572438_ChIP-Seq_LNCaP_Human	1.74121371
27	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.68858206
28	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.68858206
29	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.67930294
30	STAT3_23295773_ChIP-Seq_U87_Human	1.67085871
31	EWS_26573619_Chip-Seq_HEK293_Human	1.66306188
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.62134101
33	TCF4_23295773_ChIP-Seq_U87_Human	1.59343912
34	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57760563
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.55723600
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.52388953
37	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.51156578
38	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.49921887
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45483344
40	AR_25329375_ChIP-Seq_VCAP_Human	1.45348786
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41050141
42	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.38176394
43	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.37851717
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35229517
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34187813
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.34187813
47	AHR_22903824_ChIP-Seq_MCF-7_Human	1.33773036
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.33378249
49	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31379091
50	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.29015334
51	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27971649
52	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.26558156
53	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.26027590
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25603530
55	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25479117
56	RXR_22108803_ChIP-Seq_LS180_Human	1.24991591
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.24750381
58	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22372514
59	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.21275929
60	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.20696394
61	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19892461
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19397920
63	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18570368
64	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.18444417
65	CDX2_22108803_ChIP-Seq_LS180_Human	1.18166949
66	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.17666957
67	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.16945741
68	RNF2_27304074_Chip-Seq_NSC_Mouse	1.16468880
69	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.15373902
70	REST_21632747_ChIP-Seq_MESCs_Mouse	1.15359018
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14899075
72	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.14448327
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13981426
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13452751
75	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13452751
76	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.13370929
77	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.12397921
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10655844
79	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.10622519
80	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.09516820
81	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.09232563
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08261200
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08144386
84	P53_22387025_ChIP-Seq_ESCs_Mouse	1.07333863
85	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.06990357
86	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.06798524
87	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.06668076
88	TP53_16413492_ChIP-PET_HCT116_Human	1.06409592
89	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04907753
90	TP53_22573176_ChIP-Seq_HFKS_Human	1.04601198
91	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.04355150
92	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.04355150
93	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.02792300
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01560270
95	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01271367
96	KDM2B_26808549_Chip-Seq_REH_Human	1.00882265
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00369679
98	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.00103864
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98923889
100	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98923889

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.92585459
2	MP0010386_abnormal_urinary_bladder	2.83973590
3	MP0003195_calcinosis	2.62560219
4	MP0002102_abnormal_ear_morphology	2.51477640
5	MP0001968_abnormal_touch/_nociception	2.39418708
6	MP0008877_abnormal_DNA_methylation	2.37331019
7	MP0005551_abnormal_eye_electrophysiolog	2.17572744
8	MP0004885_abnormal_endolymph	2.14148143
9	MP0009046_muscle_twitch	2.07876860
10	MP0001986_abnormal_taste_sensitivity	2.06074387
11	MP0002736_abnormal_nociception_after	2.05918818
12	MP0003136_yellow_coat_color	2.01298785
13	MP0006276_abnormal_autonomic_nervous	1.94027734
14	MP0005646_abnormal_pituitary_gland	1.91399484
15	MP0005174_abnormal_tail_pigmentation	1.91107189
16	MP0000427_abnormal_hair_cycle	1.84291556
17	MP0002638_abnormal_pupillary_reflex	1.83442606
18	MP0004145_abnormal_muscle_electrophysio	1.83439304
19	MP0001501_abnormal_sleep_pattern	1.70660128
20	MP0005220_abnormal_exocrine_pancreas	1.64676313
21	MP0002653_abnormal_ependyma_morphology	1.63135014
22	MP0006072_abnormal_retinal_apoptosis	1.62653794
23	MP0000383_abnormal_hair_follicle	1.62332572
24	MP0004043_abnormal_pH_regulation	1.59837281
25	MP0001486_abnormal_startle_reflex	1.58113267
26	MP0004142_abnormal_muscle_tone	1.56246082
27	MP0005253_abnormal_eye_physiology	1.56016830
28	MP0008872_abnormal_physiological_respon	1.51266947
29	MP0002272_abnormal_nervous_system	1.50371256
30	MP0000631_abnormal_neuroendocrine_gland	1.49713906
31	MP0009745_abnormal_behavioral_response	1.49275698
32	MP0008057_abnormal_DNA_replication	1.48569507
33	MP0006292_abnormal_olfactory_placode	1.48117759
34	MP0010368_abnormal_lymphatic_system	1.47769027
35	MP0005645_abnormal_hypothalamus_physiol	1.47534441
36	MP0000538_abnormal_urinary_bladder	1.46949527
37	MP0004924_abnormal_behavior	1.44540789
38	MP0005386_behavior/neurological_phenoty	1.44540789
39	MP0002938_white_spotting	1.43732557
40	MP0001440_abnormal_grooming_behavior	1.43610494
41	MP0000516_abnormal_urinary_system	1.42689229
42	MP0005367_renal/urinary_system_phenotyp	1.42689229
43	MP0003646_muscle_fatigue	1.40106724
44	MP0002572_abnormal_emotion/affect_behav	1.36323795
45	MP0004742_abnormal_vestibular_system	1.35884014
46	MP0003880_abnormal_central_pattern	1.30187996
47	MP0000230_abnormal_systemic_arterial	1.29100372
48	MP0003635_abnormal_synaptic_transmissio	1.23641867
49	MP0002733_abnormal_thermal_nociception	1.23517925
50	MP0002557_abnormal_social/conspecific_i	1.22520194
51	MP0002064_seizures	1.18536367
52	MP0002067_abnormal_sensory_capabilities	1.18468975
53	MP0000778_abnormal_nervous_system	1.15408345
54	MP0003011_delayed_dark_adaptation	1.13279571
55	MP0005595_abnormal_vascular_smooth	1.13139813
56	MP0001970_abnormal_pain_threshold	1.13041160
57	MP0004215_abnormal_myocardial_fiber	1.11283289
58	MP0002837_dystrophic_cardiac_calcinosis	1.10817943
59	MP0002735_abnormal_chemical_nociception	1.09964074
60	MP0002138_abnormal_hepatobiliary_system	1.09959725
61	MP0001485_abnormal_pinna_reflex	1.09934001
62	MP0003787_abnormal_imprinting	1.09526992
63	MP0001984_abnormal_olfaction	1.09202215
64	MP0005647_abnormal_sex_gland	1.07535920
65	MP0002876_abnormal_thyroid_physiology	1.07125787
66	MP0002734_abnormal_mechanical_nocicepti	1.02668377
67	MP0002063_abnormal_learning/memory/cond	1.00463645
68	MP0008875_abnormal_xenobiotic_pharmacok	0.99282256
69	MP0000639_abnormal_adrenal_gland	0.95474957
70	MP0001177_atelectasis	0.94630159
71	MP0004084_abnormal_cardiac_muscle	0.89773991
72	MP0008995_early_reproductive_senescence	0.87899893
73	MP0000026_abnormal_inner_ear	0.85931615
74	MP0005085_abnormal_gallbladder_physiolo	0.84551860
75	MP0009384_cardiac_valve_regurgitation	0.84442757
76	MP0001756_abnormal_urination	0.83050190
77	MP0003567_abnormal_fetal_cardiomyocyte	0.82744609
78	MP0002184_abnormal_innervation	0.81497173
79	MP0004085_abnormal_heartbeat	0.80774011
80	MP0004270_analgesia	0.79380939
81	MP0005195_abnormal_posterior_eye	0.79086577
82	MP0003385_abnormal_body_wall	0.78679610
83	MP0004133_heterotaxia	0.77797257
84	MP0009780_abnormal_chondrocyte_physiolo	0.75795676
85	MP0002282_abnormal_trachea_morphology	0.74000426
86	MP0000647_abnormal_sebaceous_gland	0.73711341
87	MP0002928_abnormal_bile_duct	0.73702519
88	MP0002752_abnormal_somatic_nervous	0.72910737
89	MP0000015_abnormal_ear_pigmentation	0.72229873
90	MP0001324_abnormal_eye_pigmentation	0.71718442
91	MP0005423_abnormal_somatic_nervous	0.71211982
92	MP0002095_abnormal_skin_pigmentation	0.70882151
93	MP0001919_abnormal_reproductive_system	0.69783886
94	MP0003950_abnormal_plasma_membrane	0.69486108
95	MP0002109_abnormal_limb_morphology	0.68049463
96	MP0002751_abnormal_autonomic_nervous	0.67946832
97	MP0001286_abnormal_eye_development	0.67767341
98	MP0003183_abnormal_peptide_metabolism	0.67581783
99	MP0010329_abnormal_lipoprotein_level	0.66022524
100	MP0004130_abnormal_muscle_cell	0.65815574

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomach cancer (HP:0012126)	6.03237511
2	Hyperventilation (HP:0002883)	4.69689043
3	Pancreatic cysts (HP:0001737)	4.36992853
4	True hermaphroditism (HP:0010459)	4.18819661
5	Abnormality of the renal cortex (HP:0011035)	4.17570809
6	Pancreatic fibrosis (HP:0100732)	4.02653643
7	Medial flaring of the eyebrow (HP:0010747)	3.51694205
8	Renal cortical cysts (HP:0000803)	3.50519593
9	Congenital stationary night blindness (HP:0007642)	3.49588708
10	Molar tooth sign on MRI (HP:0002419)	3.28335994
11	Abnormality of midbrain morphology (HP:0002418)	3.28335994
12	Abnormality of the renal medulla (HP:0100957)	3.24632605
13	Nephronophthisis (HP:0000090)	3.20011940
14	Broad-based gait (HP:0002136)	3.06994963
15	Cystic liver disease (HP:0006706)	3.04360988
16	Gaze-evoked nystagmus (HP:0000640)	3.00870717
17	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	3.00332102
18	Tubular atrophy (HP:0000092)	2.90362251
19	Fair hair (HP:0002286)	2.86545933
20	Genetic anticipation (HP:0003743)	2.78274310
21	Polydipsia (HP:0001959)	2.77794947
22	Abnormal drinking behavior (HP:0030082)	2.77794947
23	Chronic hepatic failure (HP:0100626)	2.75475076
24	Attenuation of retinal blood vessels (HP:0007843)	2.73824833
25	Progressive cerebellar ataxia (HP:0002073)	2.69701562
26	Colon cancer (HP:0003003)	2.68879249
27	Absent speech (HP:0001344)	2.64959421
28	Short chin (HP:0000331)	2.64310414
29	Gait imbalance (HP:0002141)	2.58254100
30	Abolished electroretinogram (ERG) (HP:0000550)	2.56062202
31	Abnormality of B cell number (HP:0010975)	2.46253774
32	Tubulointerstitial fibrosis (HP:0005576)	2.46116014
33	Nephrogenic diabetes insipidus (HP:0009806)	2.45522171
34	Congenital primary aphakia (HP:0007707)	2.45104621
35	Genital tract atresia (HP:0001827)	2.44259345
36	Tubulointerstitial abnormality (HP:0001969)	2.43772583
37	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.40057510
38	Absent/shortened dynein arms (HP:0200106)	2.40057510
39	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.39984673
40	Febrile seizures (HP:0002373)	2.37990838
41	Vaginal atresia (HP:0000148)	2.37621537
42	Clumsiness (HP:0002312)	2.36107359
43	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.35328090
44	Thyroid-stimulating hormone excess (HP:0002925)	2.31868275
45	Focal motor seizures (HP:0011153)	2.29048964
46	Generalized hypopigmentation of hair (HP:0011358)	2.28640784
47	Protruding tongue (HP:0010808)	2.22658913
48	Inability to walk (HP:0002540)	2.19132664
49	Conical tooth (HP:0000698)	2.15722478
50	Congenital hepatic fibrosis (HP:0002612)	2.15640272
51	Hematochezia (HP:0002573)	2.13817839
52	Polyuria (HP:0000103)	2.10954865
53	Bulbous nose (HP:0000414)	2.10113120
54	Type II lissencephaly (HP:0007260)	2.08324087
55	Postaxial foot polydactyly (HP:0001830)	2.08232918
56	Hemiparesis (HP:0001269)	2.07775345
57	Male pseudohermaphroditism (HP:0000037)	2.04894349
58	Severe visual impairment (HP:0001141)	2.01713425
59	Supernumerary spleens (HP:0009799)	1.97969501
60	Hyperphosphatemia (HP:0002905)	1.95818151
61	Bile duct proliferation (HP:0001408)	1.93851926
62	Abnormal biliary tract physiology (HP:0012439)	1.93851926
63	Macular degeneration (HP:0000608)	1.93776528
64	Increased corneal curvature (HP:0100692)	1.93620189
65	Keratoconus (HP:0000563)	1.93620189
66	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.93483679
67	Progressive inability to walk (HP:0002505)	1.93108186
68	Hypothermia (HP:0002045)	1.90013254
69	Cupped ear (HP:0000378)	1.89180912
70	Amelogenesis imperfecta (HP:0000705)	1.88169472
71	Postaxial hand polydactyly (HP:0001162)	1.87265247
72	Abnormality of incisor morphology (HP:0011063)	1.86382336
73	Abnormal ciliary motility (HP:0012262)	1.85225934
74	Widely spaced teeth (HP:0000687)	1.83526787
75	Tubulointerstitial nephritis (HP:0001970)	1.83390730
76	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.83218982
77	Furrowed tongue (HP:0000221)	1.82517772
78	Delayed CNS myelination (HP:0002188)	1.81906431
79	Decreased circulating renin level (HP:0003351)	1.81742198
80	Drooling (HP:0002307)	1.79941744
81	Cerebellar dysplasia (HP:0007033)	1.79861916
82	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.78591698
83	Abnormal respiratory epithelium morphology (HP:0012253)	1.78513070
84	Abnormal respiratory motile cilium morphology (HP:0005938)	1.78513070
85	Autoimmune thrombocytopenia (HP:0001973)	1.77587165
86	Long nose (HP:0003189)	1.76664876
87	Hypoplastic iliac wings (HP:0002866)	1.76579248
88	Short foot (HP:0001773)	1.76368830
89	Narrow forehead (HP:0000341)	1.75441619
90	Asplenia (HP:0001746)	1.75052306
91	Prostate neoplasm (HP:0100787)	1.73515120
92	Poor coordination (HP:0002370)	1.73510205
93	Focal seizures (HP:0007359)	1.72514181
94	Abnormality of the axillary hair (HP:0100134)	1.71870309
95	Abnormality of secondary sexual hair (HP:0009888)	1.71870309
96	Sclerocornea (HP:0000647)	1.71777081
97	Congenital, generalized hypertrichosis (HP:0004540)	1.71081616
98	2-3 toe syndactyly (HP:0004691)	1.70740576
99	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.69239886
100	Concave nail (HP:0001598)	1.68522916

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.34697795
2	MAP3K10	4.16372249
3	BMPR1B	3.98991286
4	TAOK3	2.84141615
5	DAPK2	2.82109729
6	ADRBK2	2.56108855
7	AKT3	2.38773832
8	GRK1	2.29747336
9	MAPK13	2.26601647
10	TGFBR1	2.10613208
11	PINK1	2.00492235
12	STK38	1.92958100
13	CASK	1.83915230
14	WNK3	1.78085584
15	FGFR2	1.70865345
16	WNK4	1.65568430
17	TEC	1.59862389
18	TLK1	1.59679750
19	STK38L	1.54391371
20	NLK	1.48383243
21	INSRR	1.48246270
22	PLK2	1.46594493
23	PNCK	1.42268503
24	SGK2	1.41952409
25	NTRK3	1.33274614
26	MAP4K2	1.32829183
27	CAMKK2	1.29525311
28	ACVR1B	1.26064208
29	NUAK1	1.23046745
30	WNK1	1.21573019
31	MARK1	1.20188195
32	KIT	1.16347312
33	CDK8	1.14905432
34	PAK3	1.14614361
35	TNIK	1.06475849
36	ITK	1.06224874
37	MAP2K2	1.05597093
38	PRKCE	1.05052516
39	PRKD2	1.04062391
40	BRSK2	1.03042271
41	SGK3	1.02272248
42	ADRBK1	0.97766801
43	SGK494	0.92800164
44	SGK223	0.92800164
45	ZAK	0.91881625
46	OXSR1	0.89678482
47	MKNK2	0.89195612
48	PRKD3	0.88296352
49	MAP3K4	0.85721345
50	STK39	0.74548548
51	PKN1	0.73053478
52	MAPK15	0.72949821
53	WEE1	0.70882020
54	NTRK2	0.66706316
55	OBSCN	0.60390399
56	GRK7	0.60092144
57	FLT3	0.59395540
58	PIK3CA	0.58040761
59	EPHA4	0.56997446
60	PTK2B	0.56777763
61	PRKCG	0.56667836
62	CHUK	0.53714521
63	TIE1	0.53431827
64	ERBB2	0.52727773
65	TAF1	0.51664829
66	HIPK2	0.50018770
67	CAMKK1	0.48126601
68	PHKG2	0.47470134
69	PHKG1	0.47470134
70	DYRK2	0.46930012
71	YES1	0.46831126
72	IKBKB	0.45756768
73	NEK9	0.45414726
74	PRKACA	0.43882471
75	BTK	0.43083455
76	SGK1	0.42527325
77	IGF1R	0.42174978
78	CSNK1D	0.41384639
79	TXK	0.41312152
80	RIPK1	0.40720159
81	DYRK1A	0.40005400
82	CAMK2A	0.39144605
83	TRIM28	0.39088314
84	RPS6KA6	0.38929568
85	CSNK1G1	0.37539213
86	PRKAA1	0.34525799
87	PRKCH	0.34309127
88	STK11	0.34299556
89	SIK2	0.33340124
90	MAP3K7	0.33193532
91	MAP2K7	0.33042410
92	ROCK1	0.32505709
93	MAPKAPK3	0.32082960
94	CSNK1A1L	0.30851463
95	PRKCI	0.30531160
96	DAPK1	0.29579427
97	PRKG1	0.29206450
98	MUSK	0.28523603
99	STK3	0.27441607
100	CAMK4	0.27243334

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.39185675
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.59975761
3	Asthma_Homo sapiens_hsa05310	2.39389687
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.25183063
5	Phototransduction_Homo sapiens_hsa04744	2.18278324
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.08621919
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.03616164
8	Nicotine addiction_Homo sapiens_hsa05033	1.95200101
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.90185973
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.86172908
11	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.84865578
12	Ether lipid metabolism_Homo sapiens_hsa00565	1.78768243
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.74397181
14	Taste transduction_Homo sapiens_hsa04742	1.71463440
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.68905849
16	Allograft rejection_Homo sapiens_hsa05330	1.66532634
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.63105347
18	Retinol metabolism_Homo sapiens_hsa00830	1.62728789
19	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.59363814
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59348484
21	Graft-versus-host disease_Homo sapiens_hsa05332	1.55229335
22	ABC transporters_Homo sapiens_hsa02010	1.52438100
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.50068144
24	Morphine addiction_Homo sapiens_hsa05032	1.49274150
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.47585705
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.42229688
27	Circadian entrainment_Homo sapiens_hsa04713	1.40812754
28	Butanoate metabolism_Homo sapiens_hsa00650	1.40636090
29	Insulin secretion_Homo sapiens_hsa04911	1.36828228
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.35176261
31	Regulation of autophagy_Homo sapiens_hsa04140	1.34045332
32	Glutamatergic synapse_Homo sapiens_hsa04724	1.30773570
33	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.29530773
34	Salivary secretion_Homo sapiens_hsa04970	1.27056189
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.19111532
36	Serotonergic synapse_Homo sapiens_hsa04726	1.15241715
37	Olfactory transduction_Homo sapiens_hsa04740	1.14420904
38	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.11975043
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.11902763
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.11225835
41	GABAergic synapse_Homo sapiens_hsa04727	1.10777906
42	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.10769076
43	Caffeine metabolism_Homo sapiens_hsa00232	1.09943637
44	Renin secretion_Homo sapiens_hsa04924	1.08538747
45	Long-term depression_Homo sapiens_hsa04730	1.08170477
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.06821848
47	Peroxisome_Homo sapiens_hsa04146	1.06458037
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03240728
49	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00591151
50	Calcium signaling pathway_Homo sapiens_hsa04020	1.00294481
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.00236039
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.98512238
53	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.95223728
54	Cholinergic synapse_Homo sapiens_hsa04725	0.91345628
55	Gastric acid secretion_Homo sapiens_hsa04971	0.90990001
56	Cocaine addiction_Homo sapiens_hsa05030	0.90970029
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.89912693
58	cAMP signaling pathway_Homo sapiens_hsa04024	0.87580027
59	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.81742209
60	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.81103449
61	Histidine metabolism_Homo sapiens_hsa00340	0.80927897
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.79229427
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.79120032
64	Basal transcription factors_Homo sapiens_hsa03022	0.74779537
65	RNA degradation_Homo sapiens_hsa03018	0.72109930
66	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.71982277
67	Amphetamine addiction_Homo sapiens_hsa05031	0.71766091
68	Dopaminergic synapse_Homo sapiens_hsa04728	0.70704582
69	Propanoate metabolism_Homo sapiens_hsa00640	0.69479513
70	Basal cell carcinoma_Homo sapiens_hsa05217	0.68523522
71	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.65450292
72	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.63011737
73	Fatty acid degradation_Homo sapiens_hsa00071	0.60133730
74	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.58010325
75	Rheumatoid arthritis_Homo sapiens_hsa05323	0.54143587
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52495255
77	Circadian rhythm_Homo sapiens_hsa04710	0.49587590
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49473535
79	Lysine degradation_Homo sapiens_hsa00310	0.48685104
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.47238822
81	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.47070873
82	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46543173
83	Mineral absorption_Homo sapiens_hsa04978	0.45749949
84	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.44301541
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.44243038
86	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.43883056
87	Primary immunodeficiency_Homo sapiens_hsa05340	0.43245592
88	Ras signaling pathway_Homo sapiens_hsa04014	0.41988337
89	Fanconi anemia pathway_Homo sapiens_hsa03460	0.40578263
90	Axon guidance_Homo sapiens_hsa04360	0.39941780
91	Pancreatic secretion_Homo sapiens_hsa04972	0.39076663
92	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.38720327
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38471452
94	p53 signaling pathway_Homo sapiens_hsa04115	0.37304078
95	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.37038253
96	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.36875455
97	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.36248741
98	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.34359087
99	Viral myocarditis_Homo sapiens_hsa05416	0.33903524
100	Protein digestion and absorption_Homo sapiens_hsa04974	0.33692251

ZNF528

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »