ZNF530

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.00783300
2nucleobase catabolic process (GO:0046113)5.62932008
3UMP biosynthetic process (GO:0006222)4.45594907
4pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)4.45594907
5UMP metabolic process (GO:0046049)4.45594907
6pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)4.45594907
7DNA double-strand break processing (GO:0000729)4.42547876
8pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)4.17526844
9RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.12413032
10rRNA catabolic process (GO:0016075)3.85751272
11negative regulation of DNA-dependent DNA replication (GO:2000104)3.85054948
12pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.76589883
13replication fork processing (GO:0031297)3.68645486
14protein K11-linked deubiquitination (GO:0035871)3.67016235
15proteasome assembly (GO:0043248)3.58120554
16nucleotide-excision repair, DNA gap filling (GO:0006297)3.45121288
17translesion synthesis (GO:0019985)3.43081451
18behavioral response to nicotine (GO:0035095)3.42817633
19recombinational repair (GO:0000725)3.40328766
20regulation of nuclear cell cycle DNA replication (GO:0033262)3.39943642
21regulation of DNA endoreduplication (GO:0032875)3.39879678
22double-strand break repair via homologous recombination (GO:0000724)3.39800205
23piRNA metabolic process (GO:0034587)3.38100541
24maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.36105909
25centriole replication (GO:0007099)3.33934543
26regulation of centriole replication (GO:0046599)3.32426711
27DNA damage response, detection of DNA damage (GO:0042769)3.31905995
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31223934
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.31223934
30NADH dehydrogenase complex assembly (GO:0010257)3.31223934
31maturation of 5.8S rRNA (GO:0000460)3.26830311
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25826579
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.25826579
34protein complex biogenesis (GO:0070271)3.25143780
35mitochondrial respiratory chain complex assembly (GO:0033108)3.24094108
36postreplication repair (GO:0006301)3.24087450
37DNA replication checkpoint (GO:0000076)3.21576944
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12761865
39DNA replication-dependent nucleosome organization (GO:0034723)3.12077698
40DNA replication-dependent nucleosome assembly (GO:0006335)3.12077698
41DNA deamination (GO:0045006)3.07622262
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07309834
43protein K6-linked ubiquitination (GO:0085020)3.05948099
44respiratory chain complex IV assembly (GO:0008535)3.02086601
45indolalkylamine metabolic process (GO:0006586)3.01253462
46atrial cardiac muscle cell action potential (GO:0086014)3.00182492
47DNA integration (GO:0015074)2.97510380
48synapsis (GO:0007129)2.97429162
49regulation of feeding behavior (GO:0060259)2.94505619
50regulation of hexokinase activity (GO:1903299)2.94360420
51regulation of glucokinase activity (GO:0033131)2.94360420
52response to pheromone (GO:0019236)2.92504561
53cell wall macromolecule metabolic process (GO:0044036)2.89362224
54DNA strand elongation involved in DNA replication (GO:0006271)2.87685632
55cytochrome complex assembly (GO:0017004)2.84520441
56ubiquinone biosynthetic process (GO:0006744)2.83696608
57DNA catabolic process, exonucleolytic (GO:0000738)2.83048482
58kinetochore assembly (GO:0051382)2.82300196
59histone mRNA metabolic process (GO:0008334)2.82256355
60DNA replication initiation (GO:0006270)2.79723655
61regulation of acrosome reaction (GO:0060046)2.78913851
62pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.78872251
63DNA strand elongation (GO:0022616)2.77275228
64ubiquinone metabolic process (GO:0006743)2.77231060
65telomere maintenance via semi-conservative replication (GO:0032201)2.77072350
66peptidyl-histidine modification (GO:0018202)2.75130461
67male meiosis I (GO:0007141)2.74747554
68DNA methylation involved in gamete generation (GO:0043046)2.70110802
69axoneme assembly (GO:0035082)2.69278575
70acrosome assembly (GO:0001675)2.68740063
71ncRNA catabolic process (GO:0034661)2.65170822
72fucose catabolic process (GO:0019317)2.64618182
73L-fucose metabolic process (GO:0042354)2.64618182
74L-fucose catabolic process (GO:0042355)2.64618182
75RNA phosphodiester bond hydrolysis (GO:0090501)2.64432467
76telomere maintenance via recombination (GO:0000722)2.64067977
77pyrimidine nucleobase metabolic process (GO:0006206)2.61586073
78meiotic chromosome segregation (GO:0045132)2.61416152
79chromatin remodeling at centromere (GO:0031055)2.61080713
80detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60413267
81kinetochore organization (GO:0051383)2.60268880
82DNA-dependent DNA replication (GO:0006261)2.59520204
83brain morphogenesis (GO:0048854)2.58959098
84neural tube formation (GO:0001841)2.57453169
85pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.55725058
86reciprocal meiotic recombination (GO:0007131)2.55105318
87reciprocal DNA recombination (GO:0035825)2.55105318
88regulation of mitotic spindle checkpoint (GO:1903504)2.54300181
89regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.54300181
90double-strand break repair (GO:0006302)2.54145451
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.53134473
92anterograde synaptic vesicle transport (GO:0048490)2.52723192
93non-recombinational repair (GO:0000726)2.51733572
94double-strand break repair via nonhomologous end joining (GO:0006303)2.51733572
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51700864
96RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51700864
97retinal rod cell development (GO:0046548)2.50325444
98CENP-A containing nucleosome assembly (GO:0034080)2.50250245
99regulation of centrosome cycle (GO:0046605)2.47156902
100mitochondrial RNA metabolic process (GO:0000959)2.46634265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.76884328
2ZNF274_21170338_ChIP-Seq_K562_Hela4.51119415
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33963323
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.92810561
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.89519939
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87220751
7* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83679924
8* EST1_17652178_ChIP-ChIP_JURKAT_Human2.78121538
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66419411
10* GABP_17652178_ChIP-ChIP_JURKAT_Human2.64319265
11EWS_26573619_Chip-Seq_HEK293_Human2.43091489
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42056440
13VDR_22108803_ChIP-Seq_LS180_Human2.34901113
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.30394851
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.29362975
16VDR_23849224_ChIP-Seq_CD4+_Human2.24723919
17IGF1R_20145208_ChIP-Seq_DFB_Human2.24074014
18GBX2_23144817_ChIP-Seq_PC3_Human2.23199211
19FUS_26573619_Chip-Seq_HEK293_Human2.17500240
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09031231
21EZH2_22144423_ChIP-Seq_EOC_Human2.07425941
22ELK1_19687146_ChIP-ChIP_HELA_Human2.03232877
23* ETS1_20019798_ChIP-Seq_JURKAT_Human2.00297647
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98114597
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95238720
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83460088
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80030644
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78467511
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77248591
30MYC_18940864_ChIP-ChIP_HL60_Human1.75016284
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74661488
32FOXP3_21729870_ChIP-Seq_TREG_Human1.73467401
33P300_19829295_ChIP-Seq_ESCs_Human1.69090503
34IRF1_19129219_ChIP-ChIP_H3396_Human1.59293112
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58406873
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58320294
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57088411
38TP53_22573176_ChIP-Seq_HFKS_Human1.56294686
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.55898974
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54782184
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51165579
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51122931
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.47960260
44TAF15_26573619_Chip-Seq_HEK293_Human1.45084099
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42885937
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39148835
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38427222
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37933358
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36906624
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31057826
51* GABP_19822575_ChIP-Seq_HepG2_Human1.29045233
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28182295
53CBP_20019798_ChIP-Seq_JUKART_Human1.26284919
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26284919
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25443224
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25378100
57STAT3_23295773_ChIP-Seq_U87_Human1.25272962
58DCP1A_22483619_ChIP-Seq_HELA_Human1.22095644
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22020705
60ER_23166858_ChIP-Seq_MCF-7_Human1.15922530
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.14985033
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12452547
63TCF4_22108803_ChIP-Seq_LS180_Human1.12411734
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.11865070
65SMAD4_21799915_ChIP-Seq_A2780_Human1.11497362
66KDM5A_27292631_Chip-Seq_BREAST_Human1.11217754
67BCAT_22108803_ChIP-Seq_LS180_Human1.10958330
68TCF4_23295773_ChIP-Seq_U87_Human1.09055625
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08902854
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.08356111
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06448606
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06153208
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05436408
74AR_25329375_ChIP-Seq_VCAP_Human1.03721677
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03055474
76CIITA_25753668_ChIP-Seq_RAJI_Human1.02199715
77NCOR_22424771_ChIP-Seq_293T_Human1.02003082
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99116895
79RUNX2_22187159_ChIP-Seq_PCA_Human0.99042361
80PIAS1_25552417_ChIP-Seq_VCAP_Human0.98666878
81SOX2_19829295_ChIP-Seq_ESCs_Human0.97123483
82NANOG_19829295_ChIP-Seq_ESCs_Human0.97123483
83TTF2_22483619_ChIP-Seq_HELA_Human0.96114415
84FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93847636
85FOXA1_25329375_ChIP-Seq_VCAP_Human0.93847636
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92175719
87THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91830518
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91196113
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90643079
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.90473136
91AR_20517297_ChIP-Seq_VCAP_Human0.89637981
92SMAD3_21741376_ChIP-Seq_EPCs_Human0.87348061
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87096881
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86967518
95MYC_18555785_ChIP-Seq_MESCs_Mouse0.86919863
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86581011
97HOXB7_26014856_ChIP-Seq_BT474_Human0.86469727
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86317731
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86113537
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83902515

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.35116919
2MP0008058_abnormal_DNA_repair3.27193390
3MP0008877_abnormal_DNA_methylation3.17745421
4MP0008057_abnormal_DNA_replication3.10019058
5MP0000372_irregular_coat_pigmentation2.69420675
6MP0003718_maternal_effect2.57566565
7MP0006292_abnormal_olfactory_placode2.50602711
8MP0001529_abnormal_vocalization2.36206199
9MP0002102_abnormal_ear_morphology2.33885137
10MP0002163_abnormal_gland_morphology2.21966887
11MP0008872_abnormal_physiological_respon2.11127989
12MP0005367_renal/urinary_system_phenotyp1.99619541
13MP0000516_abnormal_urinary_system1.99619541
14MP0003787_abnormal_imprinting1.98918118
15MP0002837_dystrophic_cardiac_calcinosis1.89769709
16MP0003693_abnormal_embryo_hatching1.87860881
17MP0005551_abnormal_eye_electrophysiolog1.87346146
18MP0003111_abnormal_nucleus_morphology1.86915995
19MP0001984_abnormal_olfaction1.81616914
20MP0005075_abnormal_melanosome_morpholog1.80156647
21MP0005645_abnormal_hypothalamus_physiol1.79989899
22MP0002234_abnormal_pharynx_morphology1.64852545
23MP0004147_increased_porphyrin_level1.59137131
24MP0003077_abnormal_cell_cycle1.57729905
25MP0003786_premature_aging1.56885740
26MP0003136_yellow_coat_color1.55816638
27MP0002822_catalepsy1.50164837
28MP0001968_abnormal_touch/_nociception1.50017532
29MP0003880_abnormal_central_pattern1.49690160
30MP0003806_abnormal_nucleotide_metabolis1.47446811
31MP0005379_endocrine/exocrine_gland_phen1.47280530
32MP0003646_muscle_fatigue1.46904514
33MP0002138_abnormal_hepatobiliary_system1.44826746
34MP0002876_abnormal_thyroid_physiology1.43253880
35MP0002160_abnormal_reproductive_system1.39982019
36MP0008007_abnormal_cellular_replicative1.38936432
37MP0001929_abnormal_gametogenesis1.36934115
38MP0005389_reproductive_system_phenotype1.35127970
39MP0005253_abnormal_eye_physiology1.33622671
40MP0006035_abnormal_mitochondrial_morpho1.33373235
41MP0004142_abnormal_muscle_tone1.32440667
42MP0000427_abnormal_hair_cycle1.31816927
43MP0002210_abnormal_sex_determination1.29389957
44MP0002736_abnormal_nociception_after1.26904874
45MP0001919_abnormal_reproductive_system1.26192059
46MP0002938_white_spotting1.24645898
47MP0006072_abnormal_retinal_apoptosis1.24595322
48MP0003698_abnormal_male_reproductive1.24057652
49MP0004924_abnormal_behavior1.20209110
50MP0005386_behavior/neurological_phenoty1.20209110
51MP0003121_genomic_imprinting1.19032233
52MP0001145_abnormal_male_reproductive1.17241885
53MP0008995_early_reproductive_senescence1.16424357
54MP0002751_abnormal_autonomic_nervous1.15316486
55MP0009046_muscle_twitch1.14799081
56MP0006276_abnormal_autonomic_nervous1.14730576
57MP0001324_abnormal_eye_pigmentation1.13685512
58MP0003195_calcinosis1.13358120
59MP0008789_abnormal_olfactory_epithelium1.13237712
60MP0002095_abnormal_skin_pigmentation1.11611824
61MP0000653_abnormal_sex_gland1.11212599
62MP0001986_abnormal_taste_sensitivity1.11104918
63MP0009745_abnormal_behavioral_response1.08268602
64MP0004145_abnormal_muscle_electrophysio1.05596926
65MP0009697_abnormal_copulation1.04358955
66MP0005410_abnormal_fertilization1.02907671
67MP0002735_abnormal_chemical_nociception0.99757615
68MP0004957_abnormal_blastocyst_morpholog0.97467731
69MP0005084_abnormal_gallbladder_morpholo0.97030433
70MP0000358_abnormal_cell_content/0.95670953
71MP0003656_abnormal_erythrocyte_physiolo0.95082563
72MP0006036_abnormal_mitochondrial_physio0.94039934
73MP0002653_abnormal_ependyma_morphology0.93953113
74MP0005174_abnormal_tail_pigmentation0.93889639
75MP0002638_abnormal_pupillary_reflex0.91711076
76MP0003890_abnormal_embryonic-extraembry0.91327921
77MP0000569_abnormal_digit_pigmentation0.90294873
78MP0002067_abnormal_sensory_capabilities0.88908876
79MP0001764_abnormal_homeostasis0.85199982
80MP0001486_abnormal_startle_reflex0.85075819
81MP0000631_abnormal_neuroendocrine_gland0.84181348
82MP0003567_abnormal_fetal_cardiomyocyte0.81929775
83MP0005395_other_phenotype0.80905241
84MP0005310_abnormal_salivary_gland0.80420770
85MP0005187_abnormal_penis_morphology0.78427931
86MP0005394_taste/olfaction_phenotype0.78368170
87MP0005499_abnormal_olfactory_system0.78368170
88MP0002272_abnormal_nervous_system0.77126363
89MP0000647_abnormal_sebaceous_gland0.76282993
90MP0005646_abnormal_pituitary_gland0.76018531
91MP0004043_abnormal_pH_regulation0.75553084
92MP0001119_abnormal_female_reproductive0.73856447
93MP0003943_abnormal_hepatobiliary_system0.73395211
94MP0002254_reproductive_system_inflammat0.73133239
95MP0005647_abnormal_sex_gland0.72534445
96MP0005195_abnormal_posterior_eye0.71609742
97MP0003950_abnormal_plasma_membrane0.70731924
98MP0004133_heterotaxia0.69306526
99MP0000613_abnormal_salivary_gland0.69103833
100MP0003137_abnormal_impulse_conducting0.68877346

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.64329275
2Pancreatic fibrosis (HP:0100732)3.54754532
3Abnormality of pyrimidine metabolism (HP:0004353)3.36550807
4Attenuation of retinal blood vessels (HP:0007843)3.12894097
5Congenital stationary night blindness (HP:0007642)3.06027882
6Aplasia/Hypoplasia of the tibia (HP:0005772)3.05303690
7Abnormality of midbrain morphology (HP:0002418)3.03157932
8Molar tooth sign on MRI (HP:0002419)3.03157932
9Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99713584
10Progressive inability to walk (HP:0002505)2.94736549
11Gaze-evoked nystagmus (HP:0000640)2.86444743
12Chromsome breakage (HP:0040012)2.83323352
13Neoplasm of the adrenal cortex (HP:0100641)2.80979741
14True hermaphroditism (HP:0010459)2.76458985
15Nephronophthisis (HP:0000090)2.70535461
16Aplasia/Hypoplasia of the uvula (HP:0010293)2.67695798
17Tetraplegia (HP:0002445)2.66784742
18Colon cancer (HP:0003003)2.66232000
19Lissencephaly (HP:0001339)2.66029937
20Abnormality of the renal cortex (HP:0011035)2.55842436
21Type II lissencephaly (HP:0007260)2.54097910
22Short tibia (HP:0005736)2.53385542
23Abnormality of the labia minora (HP:0012880)2.47810387
24Hyperventilation (HP:0002883)2.46605240
25Abnormality of the ileum (HP:0001549)2.46022881
26Abnormality of chromosome stability (HP:0003220)2.43902414
27Birth length less than 3rd percentile (HP:0003561)2.40533401
28Meckel diverticulum (HP:0002245)2.37676014
29Abnormality of the renal medulla (HP:0100957)2.37510796
30Pachygyria (HP:0001302)2.34776203
31Chronic hepatic failure (HP:0100626)2.29238089
32Medial flaring of the eyebrow (HP:0010747)2.27783131
33Genetic anticipation (HP:0003743)2.25639290
34Aplasia/Hypoplasia of the patella (HP:0006498)2.24793565
35Patellar aplasia (HP:0006443)2.24781269
36Inability to walk (HP:0002540)2.20135979
37Increased CSF lactate (HP:0002490)2.16447441
38Clubbing of toes (HP:0100760)2.15697984
39Pendular nystagmus (HP:0012043)2.15641615
40Focal motor seizures (HP:0011153)2.12469109
41Focal seizures (HP:0007359)2.12441654
42Hyperglycinemia (HP:0002154)2.10654367
43Ketoacidosis (HP:0001993)2.10488293
44Abnormal biliary tract physiology (HP:0012439)2.10108990
45Bile duct proliferation (HP:0001408)2.10108990
46Aplasia/Hypoplasia of the tongue (HP:0010295)2.10046607
47Abnormality of the preputium (HP:0100587)2.09702778
48Abolished electroretinogram (ERG) (HP:0000550)2.09306631
49Sloping forehead (HP:0000340)2.08529882
50Tubulointerstitial nephritis (HP:0001970)2.04535205
51Intestinal atresia (HP:0011100)2.03110341
52Preaxial hand polydactyly (HP:0001177)2.02840482
53Abnormality of the pons (HP:0007361)1.99286597
54Abnormality of alanine metabolism (HP:0010916)1.95460837
55Hyperalaninemia (HP:0003348)1.95460837
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95460837
57Progressive cerebellar ataxia (HP:0002073)1.94341161
58Hepatocellular necrosis (HP:0001404)1.93699687
59Large for gestational age (HP:0001520)1.93440546
60Broad-based gait (HP:0002136)1.93049588
61Decreased central vision (HP:0007663)1.92738999
62Hypoplasia of the pons (HP:0012110)1.90550235
63Cystic liver disease (HP:0006706)1.90385085
64Abnormal rod and cone electroretinograms (HP:0008323)1.90351091
65Gastrointestinal atresia (HP:0002589)1.89415395
66Metaphyseal dysplasia (HP:0100255)1.88832995
67Methylmalonic acidemia (HP:0002912)1.88099656
68Hypsarrhythmia (HP:0002521)1.87517611
69Cerebellar dysplasia (HP:0007033)1.87395197
70Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86949843
71Mitochondrial inheritance (HP:0001427)1.86183805
72Methylmalonic aciduria (HP:0012120)1.84936770
73Congenital hepatic fibrosis (HP:0002612)1.83898419
74Tubular atrophy (HP:0000092)1.83713670
75Lipid accumulation in hepatocytes (HP:0006561)1.83526098
76Drooling (HP:0002307)1.83486147
77Retinal dysplasia (HP:0007973)1.83253908
78Small hand (HP:0200055)1.83030652
79Ketosis (HP:0001946)1.82593427
80Postaxial foot polydactyly (HP:0001830)1.80744397
81Optic disc pallor (HP:0000543)1.79347566
82Nephroblastoma (Wilms tumor) (HP:0002667)1.79147521
83Aplasia/Hypoplasia of the spleen (HP:0010451)1.78095169
84Abnormal drinking behavior (HP:0030082)1.77649484
85Polydipsia (HP:0001959)1.77649484
86Small intestinal stenosis (HP:0012848)1.77497904
87Duodenal stenosis (HP:0100867)1.77497904
88Supernumerary spleens (HP:0009799)1.75891516
89Renal cortical cysts (HP:0000803)1.75668005
90Sclerocornea (HP:0000647)1.75621611
91Broad alveolar ridges (HP:0000187)1.75489141
92Asplenia (HP:0001746)1.75383610
93Hepatic necrosis (HP:0002605)1.74711558
94Dandy-Walker malformation (HP:0001305)1.73448814
95EEG with generalized epileptiform discharges (HP:0011198)1.72969117
96Anencephaly (HP:0002323)1.72945265
97Poikiloderma (HP:0001029)1.72499740
98Abnormality of serine family amino acid metabolism (HP:0010894)1.72494490
99Abnormality of glycine metabolism (HP:0010895)1.72494490
100Increased serum lactate (HP:0002151)1.72062988

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.28556837
2ZAK3.53658817
3BMPR1B3.50382897
4ACVR1B3.10077487
5MAP4K22.93720679
6NUAK12.32399338
7PLK42.09162522
8CDC71.93588522
9WNK31.86017012
10CLK11.82251274
11MKNK21.76097833
12CDK81.74825798
13EIF2AK31.74701145
14TRIM281.70916480
15VRK11.63221574
16BUB11.61416876
17SRPK11.60033336
18ADRBK21.54796006
19GRK11.54014255
20CAMKK21.53662418
21TLK11.42718872
22TGFBR11.42713735
23DYRK21.42076131
24INSRR1.40280166
25VRK21.39596041
26PLK31.33324357
27MAPK131.29067444
28MARK11.28707736
29WEE11.26719229
30CSNK1G31.22323028
31MKNK11.20839353
32ADRBK11.16324205
33CSNK1G21.13408059
34CSNK1G11.12729958
35MST41.12678991
36BRSK21.12331077
37CSNK1A1L1.08298077
38PLK11.05169914
39OXSR11.01968322
40CHEK21.01817765
41ATR0.99434567
42BCR0.96554614
43BCKDK0.92068599
44TTK0.91443073
45PLK20.87448185
46MAP3K40.84964743
47PINK10.83276271
48CCNB10.83222463
49ERBB30.79582664
50PAK30.78802744
51STK30.78003608
52NEK10.77373649
53ATM0.75927805
54NEK20.75462172
55RPS6KA40.75372853
56CAMK40.74879994
57RPS6KA50.68763723
58TIE10.68703393
59PRKCE0.68467650
60STK160.67271901
61DAPK10.65383881
62PRKD30.65380516
63CSNK1D0.64742547
64TEC0.63663670
65MAP2K70.62904519
66DAPK20.62724093
67CAMK1D0.60486822
68CDK190.60485410
69EIF2AK20.59556150
70PHKG10.59076108
71PHKG20.59076108
72TAOK30.59015038
73STK390.58278340
74STK110.58143852
75CHEK10.58042419
76TAF10.57667402
77MELK0.55232188
78YES10.52594968
79FGFR20.49569701
80FER0.49499438
81EIF2AK10.47253806
82FLT30.46383093
83AURKB0.46142402
84WNK40.45692571
85CASK0.44883709
86PKN10.44372342
87PRKCZ0.41748909
88DYRK30.41006577
89TSSK60.39896459
90CDK10.39180102
91KIT0.38158696
92PRKCG0.37324457
93CDK20.36482518
94PBK0.36334951
95TGFBR20.36234147
96EPHA40.36137810
97CDK70.35615065
98IRAK10.33997774
99PIM10.33304800
100TXK0.32418033

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.59459029
2Non-homologous end-joining_Homo sapiens_hsa034503.19649506
3DNA replication_Homo sapiens_hsa030303.12638077
4Fanconi anemia pathway_Homo sapiens_hsa034603.11950503
5Mismatch repair_Homo sapiens_hsa034302.92740643
6RNA polymerase_Homo sapiens_hsa030202.64896201
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64832843
8Basal transcription factors_Homo sapiens_hsa030222.60203144
9Base excision repair_Homo sapiens_hsa034102.59350743
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.59063481
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29711154
12Pyrimidine metabolism_Homo sapiens_hsa002402.18257337
13Phototransduction_Homo sapiens_hsa047442.11387033
14Nucleotide excision repair_Homo sapiens_hsa034202.08531626
15RNA degradation_Homo sapiens_hsa030182.04495038
16RNA transport_Homo sapiens_hsa030131.90053328
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87812804
18One carbon pool by folate_Homo sapiens_hsa006701.82587043
19Selenocompound metabolism_Homo sapiens_hsa004501.82521664
20Proteasome_Homo sapiens_hsa030501.82350227
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.77724088
22Butanoate metabolism_Homo sapiens_hsa006501.72963546
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71984482
24Linoleic acid metabolism_Homo sapiens_hsa005911.62918165
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58140729
26Protein export_Homo sapiens_hsa030601.44578656
27Nitrogen metabolism_Homo sapiens_hsa009101.44205806
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40913133
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38816950
30Ether lipid metabolism_Homo sapiens_hsa005651.34190117
31beta-Alanine metabolism_Homo sapiens_hsa004101.33726954
32Oxidative phosphorylation_Homo sapiens_hsa001901.33549924
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27843245
34Cell cycle_Homo sapiens_hsa041101.27117144
35Propanoate metabolism_Homo sapiens_hsa006401.26617520
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26402505
37Purine metabolism_Homo sapiens_hsa002301.22432721
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16204279
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15518431
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11895993
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.10079462
42Spliceosome_Homo sapiens_hsa030401.08967620
43Dorso-ventral axis formation_Homo sapiens_hsa043201.08011208
44Tryptophan metabolism_Homo sapiens_hsa003801.07365821
45Parkinsons disease_Homo sapiens_hsa050121.06556821
46Steroid biosynthesis_Homo sapiens_hsa001001.02565957
47p53 signaling pathway_Homo sapiens_hsa041150.99328469
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.98292442
49Huntingtons disease_Homo sapiens_hsa050160.92017669
50Primary immunodeficiency_Homo sapiens_hsa053400.86529075
51Peroxisome_Homo sapiens_hsa041460.85700508
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.82198337
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.81719266
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81118386
55Nicotine addiction_Homo sapiens_hsa050330.80810966
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79850599
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77968913
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74935624
59Olfactory transduction_Homo sapiens_hsa047400.73832026
60Metabolic pathways_Homo sapiens_hsa011000.67609320
61Lysine degradation_Homo sapiens_hsa003100.63282886
62Regulation of autophagy_Homo sapiens_hsa041400.60299210
63Circadian rhythm_Homo sapiens_hsa047100.60279111
64mRNA surveillance pathway_Homo sapiens_hsa030150.58028684
65Systemic lupus erythematosus_Homo sapiens_hsa053220.54590078
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.54451678
67Arachidonic acid metabolism_Homo sapiens_hsa005900.53251048
68Alzheimers disease_Homo sapiens_hsa050100.51330749
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50625662
70Oocyte meiosis_Homo sapiens_hsa041140.47951593
71Ovarian steroidogenesis_Homo sapiens_hsa049130.47766907
72Collecting duct acid secretion_Homo sapiens_hsa049660.45074001
73Serotonergic synapse_Homo sapiens_hsa047260.44784345
74Sulfur relay system_Homo sapiens_hsa041220.44077357
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43807050
76Caffeine metabolism_Homo sapiens_hsa002320.40686395
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40629176
78Taste transduction_Homo sapiens_hsa047420.39572114
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.38236324
80Alcoholism_Homo sapiens_hsa050340.37919058
81Pyruvate metabolism_Homo sapiens_hsa006200.37331861
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37023117
83Fatty acid metabolism_Homo sapiens_hsa012120.35731548
84N-Glycan biosynthesis_Homo sapiens_hsa005100.35340758
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34553345
86Glutathione metabolism_Homo sapiens_hsa004800.34297118
87Calcium signaling pathway_Homo sapiens_hsa040200.33724004
88Fatty acid elongation_Homo sapiens_hsa000620.27450173
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26561172
90Glycerolipid metabolism_Homo sapiens_hsa005610.25927970
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24489065
92Chemical carcinogenesis_Homo sapiens_hsa052040.23309684
93Ribosome_Homo sapiens_hsa030100.23274733
94Sphingolipid metabolism_Homo sapiens_hsa006000.22823652
95Insulin secretion_Homo sapiens_hsa049110.20395539
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20390891
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20114737
98TGF-beta signaling pathway_Homo sapiens_hsa043500.20055854
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.19823861
100Folate biosynthesis_Homo sapiens_hsa007900.19445476

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