ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	8.29247118
2	regulation of meiosis I (GO:0060631)	7.47196309
3	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	7.41108866
4	regulation of retinoic acid receptor signaling pathway (GO:0048385)	6.40070625
5	male meiosis I (GO:0007141)	5.97884207
6	synapsis (GO:0007129)	5.78793916
7	DNA methylation involved in gamete generation (GO:0043046)	5.32839357
8	somatic diversification of immune receptors via somatic mutation (GO:0002566)	5.12369364
9	somatic hypermutation of immunoglobulin genes (GO:0016446)	5.12369364
10	meiosis I (GO:0007127)	4.93319774
11	male meiosis (GO:0007140)	4.66863729
12	positive regulation of meiosis (GO:0045836)	4.56610938
13	positive regulation of meiotic cell cycle (GO:0051446)	4.49181528
14	gene silencing by RNA (GO:0031047)	4.39531809
15	DNA replication checkpoint (GO:0000076)	4.33930526
16	meiotic cell cycle (GO:0051321)	4.27823721
17	chromosome organization involved in meiosis (GO:0070192)	3.74271792
18	regulation of DNA methylation (GO:0044030)	3.74168975
19	transcription from mitochondrial promoter (GO:0006390)	3.68823359
20	meiotic nuclear division (GO:0007126)	3.68581289
21	rRNA modification (GO:0000154)	3.65397297
22	meiotic cell cycle process (GO:1903046)	3.47887727
23	rRNA methylation (GO:0031167)	3.43878762
24	meiotic chromosome segregation (GO:0045132)	3.40865656
25	resolution of meiotic recombination intermediates (GO:0000712)	3.39998818
26	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.39776023
27	termination of RNA polymerase III transcription (GO:0006386)	3.39776023
28	mitotic metaphase plate congression (GO:0007080)	3.35755644
29	gonadal mesoderm development (GO:0007506)	3.31206475
30	seminiferous tubule development (GO:0072520)	3.29765395
31	female gamete generation (GO:0007292)	3.29313113
32	N-terminal protein amino acid acetylation (GO:0006474)	3.27151285
33	acrosome reaction (GO:0007340)	3.21629979
34	negative regulation of meiosis (GO:0045835)	3.18704494
35	multicellular organism reproduction (GO:0032504)	3.08412334
36	chromatin remodeling at centromere (GO:0031055)	3.05004037
37	metaphase plate congression (GO:0051310)	3.04886573
38	base-excision repair, AP site formation (GO:0006285)	3.02526431
39	positive regulation of protein homooligomerization (GO:0032464)	2.97679207
40	mitotic sister chromatid cohesion (GO:0007064)	2.95983217
41	retinal cone cell development (GO:0046549)	2.95533088
42	autophagic vacuole assembly (GO:0000045)	2.95095392
43	DNA alkylation (GO:0006305)	2.93943239
44	DNA methylation (GO:0006306)	2.93943239
45	reciprocal meiotic recombination (GO:0007131)	2.93372748
46	reciprocal DNA recombination (GO:0035825)	2.93372748
47	protein-cofactor linkage (GO:0018065)	2.91272657
48	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.91118952
49	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.91118952
50	synaptonemal complex assembly (GO:0007130)	2.91028469
51	histone exchange (GO:0043486)	2.85842094
52	binding of sperm to zona pellucida (GO:0007339)	2.84634573
53	CENP-A containing nucleosome assembly (GO:0034080)	2.84211032
54	sperm-egg recognition (GO:0035036)	2.84109287
55	regulation of meiosis (GO:0040020)	2.82863078
56	protein polyglutamylation (GO:0018095)	2.82006815
57	regulation of mitochondrial translation (GO:0070129)	2.79907938
58	synaptonemal complex organization (GO:0070193)	2.78478016
59	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.74942860
60	gene silencing (GO:0016458)	2.73164741
61	oogenesis (GO:0048477)	2.72989970
62	protein K6-linked ubiquitination (GO:0085020)	2.72913852
63	regulation of meiotic cell cycle (GO:0051445)	2.69572536
64	dopamine biosynthetic process (GO:0042416)	2.67577444
65	mitochondrial RNA metabolic process (GO:0000959)	2.67075354
66	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.63211531
67	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.63211531
68	sperm motility (GO:0030317)	2.63203060
69	DNA catabolic process, exonucleolytic (GO:0000738)	2.62186330
70	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.61983384
71	behavioral response to nicotine (GO:0035095)	2.61334162
72	centriole replication (GO:0007099)	2.59749495
73	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.58741270
74	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.58307866
75	mismatch repair (GO:0006298)	2.57949264
76	sister chromatid cohesion (GO:0007062)	2.57856656
77	positive regulation of mRNA processing (GO:0050685)	2.57312570
78	positive regulation of chromosome segregation (GO:0051984)	2.54919074
79	attachment of spindle microtubules to kinetochore (GO:0008608)	2.54555940
80	spermatid development (GO:0007286)	2.54250661
81	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.53921675
82	somatic diversification of immunoglobulins (GO:0016445)	2.53910854
83	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.53283561
84	fertilization (GO:0009566)	2.50984822
85	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.49219862
86	glycine transport (GO:0015816)	2.48764253
87	exploration behavior (GO:0035640)	2.48757431
88	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.47570485
89	DNA methylation or demethylation (GO:0044728)	2.43689566
90	positive regulation of mRNA 3-end processing (GO:0031442)	2.43296079
91	regulation of female gonad development (GO:2000194)	2.43214441
92	DNA modification (GO:0006304)	2.43021345
93	protein localization to cilium (GO:0061512)	2.41723624
94	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.40432138
95	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.40345217
96	histone mRNA metabolic process (GO:0008334)	2.39736925
97	photoreceptor cell development (GO:0042461)	2.39609157
98	sex differentiation (GO:0007548)	2.39517522
99	formation of translation preinitiation complex (GO:0001731)	2.39303061
100	regulation of neuron projection regeneration (GO:0070570)	2.38003780

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.85998100
2	VDR_22108803_ChIP-Seq_LS180_Human	3.69925178
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.48510526
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.39034256
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.26272310
6	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.98672339
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.98352438
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.72606885
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.55022329
10	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.45405229
11	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.45405229
12	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.45405229
13	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.45395712
14	E2F7_22180533_ChIP-Seq_HELA_Human	2.40766187
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.38624068
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.06416951
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.05372264
18	IGF1R_20145208_ChIP-Seq_DFB_Human	2.04102193
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.96989281
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.93684978
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.93017558
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.83304561
23	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.79847046
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.69041553
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.68703981
26	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.68087221
27	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.67727697
28	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.67582308
29	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.64092021
30	FUS_26573619_Chip-Seq_HEK293_Human	1.61080901
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.60092288
32	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.58897568
33	EWS_26573619_Chip-Seq_HEK293_Human	1.55874312
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.53918244
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.53517565
36	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.53402003
37	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.53161921
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.51594426
39	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.49781715
40	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.49328236
41	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.48443442
42	TP53_22573176_ChIP-Seq_HFKS_Human	1.47894375
43	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.47626321
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45280611
45	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.42372045
46	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41128347
47	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.39998325
48	P300_19829295_ChIP-Seq_ESCs_Human	1.32104846
49	* BCAT_22108803_ChIP-Seq_LS180_Human	1.30289667
50	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29767988
51	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.26924889
52	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.26635897
53	FOXP3_21729870_ChIP-Seq_TREG_Human	1.25174621
54	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.23646968
55	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.20497388
56	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.18715952
57	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.17485155
58	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.16267083
59	GABP_19822575_ChIP-Seq_HepG2_Human	1.13175091
60	STAT3_23295773_ChIP-Seq_U87_Human	1.12139831
61	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.11211401
62	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11007977
63	TCF4_23295773_ChIP-Seq_U87_Human	1.10159840
64	CBP_20019798_ChIP-Seq_JUKART_Human	1.09530742
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09530742
66	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.07893499
67	TTF2_22483619_ChIP-Seq_HELA_Human	1.07519487
68	MYC_18940864_ChIP-ChIP_HL60_Human	1.06960622
69	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.04893922
70	NCOR_22424771_ChIP-Seq_293T_Human	1.03301055
71	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03001711
72	HTT_18923047_ChIP-ChIP_STHdh_Human	1.01888553
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.01883371
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01235098
75	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.00591391
76	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.00053763
77	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99930283
78	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.99930283
79	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.98807263
80	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97480092
81	ETV1_20927104_ChIP-Seq_GIST48_Human	0.96932158
82	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.95600039
83	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.95108648
84	AR_25329375_ChIP-Seq_VCAP_Human	0.94779002
85	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.93216641
86	ELK1_19687146_ChIP-ChIP_HELA_Human	0.91882010
87	RUNX2_22187159_ChIP-Seq_PCA_Human	0.91860673
88	SMAD4_21799915_ChIP-Seq_A2780_Human	0.91830399
89	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.91209716
90	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.90218065
91	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90116629
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90116629
93	HOXB7_26014856_ChIP-Seq_BT474_Human	0.89742899
94	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.88134865
95	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.86767567
96	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.85660506
97	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.84212066
98	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.83950210
99	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.83545761
100	* PRDM14_20953172_ChIP-Seq_ESCs_Human	0.83344562

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.65226718
2	MP0001986_abnormal_taste_sensitivity	4.18875022
3	MP0005423_abnormal_somatic_nervous	3.39543140
4	MP0003718_maternal_effect	3.39389009
5	MP0006292_abnormal_olfactory_placode	3.28409149
6	MP0008058_abnormal_DNA_repair	3.09095758
7	MP0003693_abnormal_embryo_hatching	2.60289015
8	MP0008057_abnormal_DNA_replication	2.41579838
9	MP0003646_muscle_fatigue	2.24700812
10	MP0010368_abnormal_lymphatic_system	2.08718615
11	MP0002210_abnormal_sex_determination	2.06411050
12	MP0003890_abnormal_embryonic-extraembry	2.03261687
13	MP0001929_abnormal_gametogenesis	1.99184451
14	MP0002735_abnormal_chemical_nociception	1.96519343
15	MP0010094_abnormal_chromosome_stability	1.89626750
16	MP0002736_abnormal_nociception_after	1.88956098
17	MP0001968_abnormal_touch/_nociception	1.86020383
18	MP0003880_abnormal_central_pattern	1.84030823
19	MP0006072_abnormal_retinal_apoptosis	1.82837598
20	MP0004885_abnormal_endolymph	1.79097325
21	MP0005551_abnormal_eye_electrophysiolog	1.77823291
22	MP0003698_abnormal_male_reproductive	1.74605479
23	MP0003121_genomic_imprinting	1.74447277
24	MP0004957_abnormal_blastocyst_morpholog	1.66475596
25	MP0008789_abnormal_olfactory_epithelium	1.65215718
26	MP0008260_abnormal_autophagy	1.64164398
27	MP0009046_muscle_twitch	1.61961120
28	MP0000569_abnormal_digit_pigmentation	1.59247972
29	MP0005394_taste/olfaction_phenotype	1.53865007
30	MP0005499_abnormal_olfactory_system	1.53865007
31	MP0006035_abnormal_mitochondrial_morpho	1.53858091
32	MP0005646_abnormal_pituitary_gland	1.53330378
33	MP0003787_abnormal_imprinting	1.53297142
34	MP0002272_abnormal_nervous_system	1.45512870
35	MP0000653_abnormal_sex_gland	1.44019936
36	MP0005410_abnormal_fertilization	1.43870520
37	MP0009745_abnormal_behavioral_response	1.43127534
38	MP0001145_abnormal_male_reproductive	1.38408646
39	MP0003123_paternal_imprinting	1.36605450
40	MP0004043_abnormal_pH_regulation	1.36120556
41	MP0004142_abnormal_muscle_tone	1.35807337
42	MP0003635_abnormal_synaptic_transmissio	1.32673880
43	MP0004215_abnormal_myocardial_fiber	1.27103609
44	MP0003077_abnormal_cell_cycle	1.22011555
45	MP0004270_analgesia	1.20921049
46	MP0002734_abnormal_mechanical_nocicepti	1.20131621
47	MP0002160_abnormal_reproductive_system	1.19924480
48	MP0002102_abnormal_ear_morphology	1.17884021
49	MP0005395_other_phenotype	1.17252623
50	MP0002161_abnormal_fertility/fecundity	1.16628229
51	MP0003119_abnormal_digestive_system	1.15662614
52	MP0001486_abnormal_startle_reflex	1.11551739
53	MP0000631_abnormal_neuroendocrine_gland	1.10741907
54	MP0009379_abnormal_foot_pigmentation	1.09142701
55	MP0005253_abnormal_eye_physiology	1.09079438
56	MP0000358_abnormal_cell_content/	1.08988478
57	MP0003111_abnormal_nucleus_morphology	1.08564023
58	MP0008932_abnormal_embryonic_tissue	1.06353463
59	MP0002064_seizures	1.05045384
60	MP0009697_abnormal_copulation	1.04381689
61	MP0001188_hyperpigmentation	1.03802490
62	MP0002067_abnormal_sensory_capabilities	1.02924136
63	MP0005174_abnormal_tail_pigmentation	1.01399434
64	MP0001905_abnormal_dopamine_level	1.00387642
65	MP0002733_abnormal_thermal_nociception	0.99899205
66	MP0002572_abnormal_emotion/affect_behav	0.98277189
67	MP0003183_abnormal_peptide_metabolism	0.97397525
68	MP0003567_abnormal_fetal_cardiomyocyte	0.95545932
69	MP0004859_abnormal_synaptic_plasticity	0.95461327
70	MP0001764_abnormal_homeostasis	0.93884691
71	MP0000049_abnormal_middle_ear	0.90533291
72	MP0003699_abnormal_female_reproductive	0.88305913
73	MP0002184_abnormal_innervation	0.88273535
74	MP0004924_abnormal_behavior	0.84555806
75	MP0005386_behavior/neurological_phenoty	0.84555806
76	MP0002234_abnormal_pharynx_morphology	0.84405103
77	MP0000778_abnormal_nervous_system	0.83011507
78	MP0001970_abnormal_pain_threshold	0.82961984
79	MP0004133_heterotaxia	0.82336640
80	MP0002822_catalepsy	0.82332576
81	MP0005389_reproductive_system_phenotype	0.82123090
82	MP0002063_abnormal_learning/memory/cond	0.81478351
83	MP0001293_anophthalmia	0.79758149
84	MP0002229_neurodegeneration	0.77944673
85	MP0002084_abnormal_developmental_patter	0.76151776
86	MP0002752_abnormal_somatic_nervous	0.75544089
87	MP0006036_abnormal_mitochondrial_physio	0.73686815
88	MP0003186_abnormal_redox_activity	0.73604984
89	MP0006276_abnormal_autonomic_nervous	0.73375119
90	MP0003861_abnormal_nervous_system	0.71801339
91	MP0003937_abnormal_limbs/digits/tail_de	0.70934387
92	MP0002882_abnormal_neuron_morphology	0.68411141
93	MP0001672_abnormal_embryogenesis/_devel	0.67996217
94	MP0005380_embryogenesis_phenotype	0.67996217
95	MP0001119_abnormal_female_reproductive	0.67939546
96	MP0008995_early_reproductive_senescence	0.67783461
97	MP0001730_embryonic_growth_arrest	0.67763420
98	MP0000026_abnormal_inner_ear	0.67491282
99	MP0002066_abnormal_motor_capabilities/c	0.66846086
100	MP0001697_abnormal_embryo_size	0.66560863

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Limb dystonia (HP:0002451)	3.85942760
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.55783449
3	Abnormality of midbrain morphology (HP:0002418)	3.40758712
4	Molar tooth sign on MRI (HP:0002419)	3.40758712
5	Oligodactyly (hands) (HP:0001180)	3.32969417
6	Colon cancer (HP:0003003)	3.05190274
7	Progressive inability to walk (HP:0002505)	2.92798876
8	Abnormal rod and cone electroretinograms (HP:0008323)	2.87638209
9	Nephronophthisis (HP:0000090)	2.79166611
10	Cerebral hypomyelination (HP:0006808)	2.78921573
11	Pancreatic fibrosis (HP:0100732)	2.76034507
12	Congenital stationary night blindness (HP:0007642)	2.74087425
13	Double outlet right ventricle (HP:0001719)	2.73698555
14	Congenital malformation of the right heart (HP:0011723)	2.73698555
15	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.70361873
16	Retinal dysplasia (HP:0007973)	2.66283017
17	Microvesicular hepatic steatosis (HP:0001414)	2.66097685
18	Birth length less than 3rd percentile (HP:0003561)	2.64726047
19	Osteomalacia (HP:0002749)	2.60196870
20	Chromsome breakage (HP:0040012)	2.58692461
21	Type II lissencephaly (HP:0007260)	2.57209713
22	CNS hypomyelination (HP:0003429)	2.54931161
23	Oligodactyly (HP:0012165)	2.46564635
24	Pancreatic cysts (HP:0001737)	2.44983327
25	Male infertility (HP:0003251)	2.42996026
26	Abolished electroretinogram (ERG) (HP:0000550)	2.39883282
27	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.39468274
28	Supernumerary spleens (HP:0009799)	2.39428199
29	Hyperglycinemia (HP:0002154)	2.39068947
30	Ependymoma (HP:0002888)	2.37881747
31	Optic nerve hypoplasia (HP:0000609)	2.37481180
32	Abdominal situs inversus (HP:0003363)	2.33202064
33	Abnormality of abdominal situs (HP:0011620)	2.33202064
34	Pendular nystagmus (HP:0012043)	2.31763977
35	Generalized aminoaciduria (HP:0002909)	2.31466577
36	Anencephaly (HP:0002323)	2.30924124
37	Abnormality of the labia minora (HP:0012880)	2.30870817
38	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.29281849
39	Scotoma (HP:0000575)	2.26349629
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.25875523
41	Tubulointerstitial nephritis (HP:0001970)	2.24221497
42	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.21357168
43	Abnormality of alanine metabolism (HP:0010916)	2.21357168
44	Hyperalaninemia (HP:0003348)	2.21357168
45	Decreased central vision (HP:0007663)	2.20887437
46	Short tibia (HP:0005736)	2.20751808
47	Medial flaring of the eyebrow (HP:0010747)	2.18857398
48	Hyperglycinuria (HP:0003108)	2.17333381
49	Amyotrophic lateral sclerosis (HP:0007354)	2.16669385
50	Gait imbalance (HP:0002141)	2.14273567
51	True hermaphroditism (HP:0010459)	2.13178507
52	Absent radius (HP:0003974)	2.11552654
53	Astrocytoma (HP:0009592)	2.11376311
54	Abnormality of the astrocytes (HP:0100707)	2.11376311
55	Abnormality of the renal medulla (HP:0100957)	2.10307933
56	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.06393230
57	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.05137655
58	Gaze-evoked nystagmus (HP:0000640)	2.04953469
59	Inability to walk (HP:0002540)	2.04716068
60	Genetic anticipation (HP:0003743)	2.04640244
61	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.04030614
62	Hypoplasia of the fovea (HP:0007750)	2.04030614
63	Aplasia involving forearm bones (HP:0009822)	2.02684314
64	Absent forearm bone (HP:0003953)	2.02684314
65	Patellar aplasia (HP:0006443)	2.00537816
66	Attenuation of retinal blood vessels (HP:0007843)	2.00327231
67	Horseshoe kidney (HP:0000085)	1.99399158
68	Carpal bone hypoplasia (HP:0001498)	1.99113668
69	Triphalangeal thumb (HP:0001199)	1.98225642
70	Azoospermia (HP:0000027)	1.96157417
71	Acute necrotizing encephalopathy (HP:0006965)	1.94579187
72	Preaxial hand polydactyly (HP:0001177)	1.94016312
73	Meckel diverticulum (HP:0002245)	1.92321452
74	Horizontal nystagmus (HP:0000666)	1.87494432
75	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.86905248
76	Impulsivity (HP:0100710)	1.86133697
77	Agnosia (HP:0010524)	1.85503456
78	Intestinal atresia (HP:0011100)	1.85032896
79	Aplasia/Hypoplasia of the patella (HP:0006498)	1.84977903
80	Abnormal respiratory motile cilium physiology (HP:0012261)	1.84914491
81	Abnormality of serine family amino acid metabolism (HP:0010894)	1.84785363
82	Abnormality of glycine metabolism (HP:0010895)	1.84785363
83	Cleft eyelid (HP:0000625)	1.84589365
84	Abnormality of the ileum (HP:0001549)	1.84455983
85	Progressive cerebellar ataxia (HP:0002073)	1.82907227
86	Abnormal spermatogenesis (HP:0008669)	1.82554071
87	Absent/shortened dynein arms (HP:0200106)	1.82506305
88	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.82506305
89	Abnormal ciliary motility (HP:0012262)	1.81432608
90	Epileptic encephalopathy (HP:0200134)	1.81339182
91	Severe visual impairment (HP:0001141)	1.80128976
92	Poor coordination (HP:0002370)	1.78906956
93	Abnormality of the costochondral junction (HP:0000919)	1.78163790
94	Congenital primary aphakia (HP:0007707)	1.77759222
95	Febrile seizures (HP:0002373)	1.76422091
96	Hypercortisolism (HP:0001578)	1.76177691
97	Lissencephaly (HP:0001339)	1.75353085
98	Hepatoblastoma (HP:0002884)	1.73962449
99	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.72440518
100	Increased CSF lactate (HP:0002490)	1.71828963

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	4.00021504
2	NTRK3	3.51223059
3	PNCK	3.38897272
4	CDK19	2.86026504
5	FRK	2.30865764
6	STK16	2.28603194
7	EPHA4	2.19376949
8	MAP4K2	2.16508054
9	BCKDK	2.15191513
10	MAPKAPK5	2.06950255
11	NUAK1	2.01125249
12	PLK4	2.00428343
13	MARK1	1.97871102
14	TRIM28	1.75950178
15	CDC7	1.72608182
16	WNK4	1.70534775
17	MAPK13	1.69360268
18	CASK	1.67550531
19	STK39	1.62489513
20	PHKG2	1.54876964
21	PHKG1	1.54876964
22	PINK1	1.45127413
23	MKNK1	1.44583472
24	TAF1	1.43101949
25	PDK2	1.42869230
26	ZAK	1.42604747
27	BUB1	1.39862297
28	WNK3	1.31105668
29	MAP3K4	1.30799752
30	PBK	1.30231657
31	NTRK2	1.28927324
32	SRPK1	1.28497023
33	TAOK3	1.26889624
34	CHEK2	1.24482598
35	PLK1	1.18013053
36	MAP3K9	1.13114959
37	TIE1	1.11484784
38	CAMK1G	1.10996750
39	TTK	1.06875049
40	PKN1	1.02720372
41	GRK1	1.01736508
42	CSNK1G2	0.96906810
43	BRSK1	0.96790394
44	NEK6	0.95021442
45	AURKA	0.93000604
46	TLK1	0.89781229
47	PRKCG	0.88537220
48	BMPR1B	0.87478466
49	TNIK	0.87350656
50	KSR2	0.86268776
51	CHEK1	0.85119851
52	DYRK2	0.84386232
53	ERBB4	0.81122372
54	STK38L	0.80471613
55	TESK2	0.79215411
56	WEE1	0.78992747
57	STK3	0.77164053
58	BRSK2	0.77138884
59	PRKACB	0.76948186
60	PLK2	0.75779618
61	LATS1	0.69537752
62	PRKCI	0.67824507
63	PAK3	0.67693498
64	STK38	0.67343499
65	RAF1	0.64964966
66	CSNK1G3	0.62228120
67	CSNK1G1	0.59966421
68	RPS6KA5	0.59757838
69	CAMK1	0.59396809
70	MAP2K7	0.59109435
71	WNK1	0.54567255
72	CAMK2A	0.53157336
73	ADRBK2	0.52763646
74	PIM1	0.52616885
75	ATM	0.51939256
76	CDK7	0.50725546
77	TNK2	0.49461695
78	ERBB3	0.49110020
79	BCR	0.48656513
80	ATR	0.47942789
81	CAMK4	0.47078161
82	CSNK1A1L	0.46252720
83	EIF2AK2	0.46206842
84	AURKB	0.46060343
85	PLK3	0.43994763
86	PRKCZ	0.43481885
87	CDK5	0.42671028
88	CDK2	0.42599983
89	PRKG1	0.42587774
90	CSNK1E	0.42381483
91	CSNK2A2	0.41016095
92	CDK1	0.40741469
93	INSRR	0.40311803
94	CSNK2A1	0.40244669
95	IRAK2	0.40165146
96	PRKACA	0.39784592
97	CDK11A	0.38065094
98	PAK6	0.37770276
99	ARAF	0.37137191
100	PTK2B	0.36873161

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	4.35346126
2	Mismatch repair_Homo sapiens_hsa03430	3.19904754
3	Base excision repair_Homo sapiens_hsa03410	3.11155112
4	Regulation of autophagy_Homo sapiens_hsa04140	2.93154926
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.90215886
6	RNA polymerase_Homo sapiens_hsa03020	2.85805960
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.68276313
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.46518959
9	RNA transport_Homo sapiens_hsa03013	2.35505962
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.31386387
11	DNA replication_Homo sapiens_hsa03030	2.26922766
12	Nicotine addiction_Homo sapiens_hsa05033	2.05670380
13	Nucleotide excision repair_Homo sapiens_hsa03420	2.01877077
14	Homologous recombination_Homo sapiens_hsa03440	2.00754694
15	Folate biosynthesis_Homo sapiens_hsa00790	1.85670276
16	Ribosome_Homo sapiens_hsa03010	1.84969177
17	Steroid biosynthesis_Homo sapiens_hsa00100	1.79415062
18	Phototransduction_Homo sapiens_hsa04744	1.78937768
19	RNA degradation_Homo sapiens_hsa03018	1.78699534
20	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.74330554
21	Cell cycle_Homo sapiens_hsa04110	1.63916675
22	Oocyte meiosis_Homo sapiens_hsa04114	1.59866035
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.49784792
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.45544450
25	mRNA surveillance pathway_Homo sapiens_hsa03015	1.44121997
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.36316923
27	Propanoate metabolism_Homo sapiens_hsa00640	1.33764505
28	Taste transduction_Homo sapiens_hsa04742	1.32013322
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.28947999
30	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.17986879
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.17314908
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.15233862
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.14434916
34	Olfactory transduction_Homo sapiens_hsa04740	1.13590072
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.11638815
36	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.09386380
37	Parkinsons disease_Homo sapiens_hsa05012	1.08893356
38	Long-term depression_Homo sapiens_hsa04730	1.05801320
39	Huntingtons disease_Homo sapiens_hsa05016	1.05667647
40	Butanoate metabolism_Homo sapiens_hsa00650	1.05640426
41	Purine metabolism_Homo sapiens_hsa00230	1.03827422
42	Oxidative phosphorylation_Homo sapiens_hsa00190	1.00643980
43	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.98501042
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94386316
45	Cardiac muscle contraction_Homo sapiens_hsa04260	0.93119335
46	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.91190101
47	One carbon pool by folate_Homo sapiens_hsa00670	0.89382553
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.87993262
49	Fatty acid elongation_Homo sapiens_hsa00062	0.87963419
50	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.85978228
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85363796
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84583315
53	Spliceosome_Homo sapiens_hsa03040	0.82983384
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.82745957
55	p53 signaling pathway_Homo sapiens_hsa04115	0.76076473
56	GABAergic synapse_Homo sapiens_hsa04727	0.75443613
57	Insulin secretion_Homo sapiens_hsa04911	0.75089511
58	ABC transporters_Homo sapiens_hsa02010	0.74870438
59	Proteasome_Homo sapiens_hsa03050	0.73130135
60	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.71671111
61	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.71418538
62	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.70654520
63	Glutamatergic synapse_Homo sapiens_hsa04724	0.70020756
64	Caffeine metabolism_Homo sapiens_hsa00232	0.68575577
65	Morphine addiction_Homo sapiens_hsa05032	0.67336334
66	Serotonergic synapse_Homo sapiens_hsa04726	0.67191261
67	Circadian entrainment_Homo sapiens_hsa04713	0.66646253
68	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65308603
69	Cocaine addiction_Homo sapiens_hsa05030	0.64178514
70	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.62126773
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.60845054
72	Dopaminergic synapse_Homo sapiens_hsa04728	0.60362910
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60267699
74	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.59460704
75	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.56320721
76	Protein export_Homo sapiens_hsa03060	0.55088236
77	Amphetamine addiction_Homo sapiens_hsa05031	0.53538942
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.52147507
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.51744367
80	Metabolic pathways_Homo sapiens_hsa01100	0.46766205
81	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.45144804
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44740049
83	Sulfur relay system_Homo sapiens_hsa04122	0.44369324
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.36513927
85	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.34890125
86	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34843512
87	Long-term potentiation_Homo sapiens_hsa04720	0.34209319
88	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.33891312
89	Alzheimers disease_Homo sapiens_hsa05010	0.33408006
90	Retinol metabolism_Homo sapiens_hsa00830	0.33201151
91	Nitrogen metabolism_Homo sapiens_hsa00910	0.32612808
92	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.28954043
93	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.27568792
94	mTOR signaling pathway_Homo sapiens_hsa04150	0.26593788
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.26538576
96	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.24800980
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.24683862
98	Wnt signaling pathway_Homo sapiens_hsa04310	0.23147439
99	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.22085289
100	Salivary secretion_Homo sapiens_hsa04970	0.21579478

ZNF534

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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