ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gamma-aminobutyric acid transport (GO:0015812)	6.58745048
2	positive regulation of mitochondrial fission (GO:0090141)	4.98556039
3	startle response (GO:0001964)	4.40461709
4	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	4.38324163
5	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.34208487
6	synaptic vesicle maturation (GO:0016188)	4.33153306
7	pyrimidine nucleobase catabolic process (GO:0006208)	4.21911731
8	synaptic vesicle exocytosis (GO:0016079)	4.16928352
9	synaptic transmission, glutamatergic (GO:0035249)	4.08366310
10	neuronal action potential propagation (GO:0019227)	4.05279574
11	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.84464972
12	neurotransmitter secretion (GO:0007269)	3.74141424
13	regulation of synaptic vesicle transport (GO:1902803)	3.72617731
14	neuron-neuron synaptic transmission (GO:0007270)	3.72561311
15	nucleobase catabolic process (GO:0046113)	3.71015947
16	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.69942191
17	glutamate secretion (GO:0014047)	3.67609276
18	neuron cell-cell adhesion (GO:0007158)	3.61687144
19	regulation of hexokinase activity (GO:1903299)	3.58175848
20	regulation of glucokinase activity (GO:0033131)	3.58175848
21	regulation of mitochondrial fission (GO:0090140)	3.54219513
22	response to pheromone (GO:0019236)	3.49774676
23	dopamine transport (GO:0015872)	3.49350268
24	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.44873787
25	protein localization to cilium (GO:0061512)	3.44645174
26	retinal cone cell development (GO:0046549)	3.41887013
27	glycerophospholipid catabolic process (GO:0046475)	3.40750285
28	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.39648942
29	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.36544740
30	glutamate receptor signaling pathway (GO:0007215)	3.29213793
31	protein localization to synapse (GO:0035418)	3.24313768
32	regulation of neurotransmitter levels (GO:0001505)	3.22580290
33	regulation of synaptic vesicle exocytosis (GO:2000300)	3.18376132
34	membrane depolarization during action potential (GO:0086010)	3.16347631
35	postsynaptic membrane organization (GO:0001941)	3.14157122
36	fucose catabolic process (GO:0019317)	3.11108643
37	L-fucose metabolic process (GO:0042354)	3.11108643
38	L-fucose catabolic process (GO:0042355)	3.11108643
39	neurotransmitter uptake (GO:0001504)	3.09567315
40	neuronal action potential (GO:0019228)	3.08227363
41	presynaptic membrane assembly (GO:0097105)	3.06593967
42	neurotransmitter transport (GO:0006836)	3.05890848
43	auditory behavior (GO:0031223)	3.05664258
44	transmission of nerve impulse (GO:0019226)	3.03436344
45	establishment of protein localization to Golgi (GO:0072600)	3.03180365
46	regulation of cilium movement (GO:0003352)	3.02159101
47	protein polyglutamylation (GO:0018095)	2.99622878
48	righting reflex (GO:0060013)	2.99177209
49	cellular ketone body metabolic process (GO:0046950)	2.94740252
50	regulation of vesicle fusion (GO:0031338)	2.94254962
51	protein targeting to Golgi (GO:0000042)	2.93083593
52	detection of light stimulus involved in visual perception (GO:0050908)	2.92672721
53	detection of light stimulus involved in sensory perception (GO:0050962)	2.92672721
54	vocalization behavior (GO:0071625)	2.92244912
55	behavioral response to nicotine (GO:0035095)	2.89813584
56	presynaptic membrane organization (GO:0097090)	2.88645517
57	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.87626211
58	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.85862456
59	synaptic vesicle endocytosis (GO:0048488)	2.85557072
60	glycosphingolipid biosynthetic process (GO:0006688)	2.85412127
61	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.84588410
62	neurotransmitter-gated ion channel clustering (GO:0072578)	2.81439212
63	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.80307257
64	C4-dicarboxylate transport (GO:0015740)	2.79698838
65	behavioral response to ethanol (GO:0048149)	2.79098019
66	regulation of synapse structural plasticity (GO:0051823)	2.78905108
67	axoneme assembly (GO:0035082)	2.77590539
68	protein-cofactor linkage (GO:0018065)	2.76850894
69	piRNA metabolic process (GO:0034587)	2.76421914
70	reflex (GO:0060004)	2.75411908
71	synapse assembly (GO:0007416)	2.73763993
72	mechanosensory behavior (GO:0007638)	2.73540454
73	regulation of feeding behavior (GO:0060259)	2.71416403
74	protein localization to Golgi apparatus (GO:0034067)	2.69909762
75	dendritic spine morphogenesis (GO:0060997)	2.69114883
76	catecholamine transport (GO:0051937)	2.68991068
77	establishment of synaptic vesicle localization (GO:0097480)	2.67511729
78	synaptic vesicle transport (GO:0048489)	2.67511729
79	establishment of mitochondrion localization (GO:0051654)	2.66667826
80	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.63809515
81	regulation of action potential (GO:0098900)	2.63102243
82	ketone body metabolic process (GO:1902224)	2.62570448
83	synaptic transmission (GO:0007268)	2.62114847
84	neuromuscular process controlling posture (GO:0050884)	2.60648664
85	axonal fasciculation (GO:0007413)	2.60579809
86	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.58847737
87	adult walking behavior (GO:0007628)	2.58738022
88	detection of calcium ion (GO:0005513)	2.58652521
89	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.58051992
90	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.58051992
91	pyrimidine dimer repair (GO:0006290)	2.57491816
92	rRNA catabolic process (GO:0016075)	2.56973286
93	establishment of vesicle localization (GO:0051650)	2.56868320
94	proline transport (GO:0015824)	2.56118139
95	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.54644757
96	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.54357231
97	neuron recognition (GO:0008038)	2.51496416
98	glycine transport (GO:0015816)	2.50682998
99	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.49767107
100	positive regulation of amino acid transport (GO:0051957)	2.49302936

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.81127569
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.77520198
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.54950139
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.14028595
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.83461707
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.82460201
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.79544665
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.77374354
9	VDR_22108803_ChIP-Seq_LS180_Human	2.52810658
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.37927197
11	REST_21632747_ChIP-Seq_MESCs_Mouse	2.34971984
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.13269853
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.13156490
14	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02342349
15	FUS_26573619_Chip-Seq_HEK293_Human	2.00041241
16	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.90423481
17	P300_19829295_ChIP-Seq_ESCs_Human	1.85723606
18	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.85471500
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83906476
20	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.81992001
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.75668258
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.69778429
23	STAT3_23295773_ChIP-Seq_U87_Human	1.68329710
24	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.68144646
25	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.67777200
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.67382679
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.67382679
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.64526846
29	EWS_26573619_Chip-Seq_HEK293_Human	1.63519353
30	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.62081717
31	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.60606344
32	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.59270393
33	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56718938
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.55933340
35	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53783619
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53242922
37	RNF2_27304074_Chip-Seq_NSC_Mouse	1.51463182
38	AR_25329375_ChIP-Seq_VCAP_Human	1.50561226
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.50378105
40	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.49786922
41	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.48513712
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.47743817
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.46217872
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.44768499
45	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44113889
46	TCF4_23295773_ChIP-Seq_U87_Human	1.41268068
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40917231
48	BCAT_22108803_ChIP-Seq_LS180_Human	1.39010275
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37645106
50	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.36829645
51	DROSHA_22980978_ChIP-Seq_HELA_Human	1.35485781
52	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.31736917
53	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.29922915
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29201463
55	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27653440
56	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.27565644
57	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26107909
58	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.23881337
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.21634355
60	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.21356232
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.20960606
62	AR_21572438_ChIP-Seq_LNCaP_Human	1.20844374
63	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.20648972
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19668667
65	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.19035085
66	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18150182
67	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.17098577
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16606837
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16606837
70	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16432775
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15008697
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.14338266
73	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.14136737
74	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13774346
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13120948
76	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12424561
77	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12064617
78	P53_22387025_ChIP-Seq_ESCs_Mouse	1.11899607
79	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11452772
80	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.10011303
81	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.09041016
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09013320
83	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.07334491
84	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.07210125
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06024074
86	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.05746226
87	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.05565105
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05137201
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04815350
90	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04794042
91	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04396893
92	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.04231864
93	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.03461027
94	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02706409
95	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.02071555
96	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02071555
97	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.01085549
98	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.99996326
99	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99510720
100	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99347363

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.76602772
2	MP0004859_abnormal_synaptic_plasticity	3.30204998
3	MP0003787_abnormal_imprinting	3.08552596
4	MP0009745_abnormal_behavioral_response	3.08265566
5	MP0009046_muscle_twitch	2.97972705
6	MP0003635_abnormal_synaptic_transmissio	2.82056127
7	MP0008877_abnormal_DNA_methylation	2.76671090
8	MP0002272_abnormal_nervous_system	2.66274329
9	MP0001968_abnormal_touch/_nociception	2.62968581
10	MP0004270_analgesia	2.62138267
11	MP0002064_seizures	2.57628557
12	MP0002102_abnormal_ear_morphology	2.54199359
13	MP0001486_abnormal_startle_reflex	2.40512434
14	MP0001986_abnormal_taste_sensitivity	2.39932850
15	MP0002822_catalepsy	2.36161153
16	MP0002063_abnormal_learning/memory/cond	2.32355156
17	MP0002572_abnormal_emotion/affect_behav	2.22122413
18	MP0002735_abnormal_chemical_nociception	2.17566099
19	MP0001501_abnormal_sleep_pattern	2.05517526
20	MP0005423_abnormal_somatic_nervous	2.05208734
21	MP0002736_abnormal_nociception_after	2.01817522
22	MP0005551_abnormal_eye_electrophysiolog	1.97656378
23	MP0002837_dystrophic_cardiac_calcinosis	1.90000274
24	MP0001984_abnormal_olfaction	1.82413661
25	MP0002734_abnormal_mechanical_nocicepti	1.81417017
26	MP0004885_abnormal_endolymph	1.73977214
27	MP0002638_abnormal_pupillary_reflex	1.69413855
28	MP0006276_abnormal_autonomic_nervous	1.69281864
29	MP0001440_abnormal_grooming_behavior	1.67476489
30	MP0002733_abnormal_thermal_nociception	1.63633482
31	MP0002067_abnormal_sensory_capabilities	1.63124893
32	MP0002557_abnormal_social/conspecific_i	1.58993526
33	MP0003122_maternal_imprinting	1.58716821
34	MP0005386_behavior/neurological_phenoty	1.58465075
35	MP0004924_abnormal_behavior	1.58465075
36	MP0005646_abnormal_pituitary_gland	1.57945197
37	MP0003195_calcinosis	1.55227267
38	MP0001970_abnormal_pain_threshold	1.53868525
39	MP0004142_abnormal_muscle_tone	1.52193112
40	MP0002928_abnormal_bile_duct	1.49324672
41	MP0001188_hyperpigmentation	1.48691333
42	MP0000778_abnormal_nervous_system	1.47161301
43	MP0001905_abnormal_dopamine_level	1.46442325
44	MP0001529_abnormal_vocalization	1.44178376
45	MP0005645_abnormal_hypothalamus_physiol	1.43738299
46	MP0003121_genomic_imprinting	1.42151299
47	MP0004811_abnormal_neuron_physiology	1.41783523
48	MP0003879_abnormal_hair_cell	1.38931968
49	MP0002909_abnormal_adrenal_gland	1.37786497
50	MP0004043_abnormal_pH_regulation	1.28743373
51	MP0005499_abnormal_olfactory_system	1.26652990
52	MP0005394_taste/olfaction_phenotype	1.26652990
53	MP0000013_abnormal_adipose_tissue	1.24328443
54	MP0002882_abnormal_neuron_morphology	1.22916237
55	MP0005253_abnormal_eye_physiology	1.22173137
56	MP0002229_neurodegeneration	1.20915599
57	MP0000569_abnormal_digit_pigmentation	1.14196880
58	MP0002184_abnormal_innervation	1.13109702
59	MP0006072_abnormal_retinal_apoptosis	1.10075211
60	MP0001485_abnormal_pinna_reflex	1.10008883
61	MP0002066_abnormal_motor_capabilities/c	1.09302280
62	MP0000955_abnormal_spinal_cord	1.09033771
63	MP0008872_abnormal_physiological_respon	1.06068391
64	MP0008995_early_reproductive_senescence	1.05643912
65	MP0008789_abnormal_olfactory_epithelium	1.03918839
66	MP0002653_abnormal_ependyma_morphology	1.02909543
67	MP0003633_abnormal_nervous_system	1.00671361
68	MP0000631_abnormal_neuroendocrine_gland	1.00310847
69	MP0005379_endocrine/exocrine_gland_phen	0.97576812
70	MP0008569_lethality_at_weaning	0.96827795
71	MP0004215_abnormal_myocardial_fiber	0.96763017
72	MP0008961_abnormal_basal_metabolism	0.96661781
73	MP0000427_abnormal_hair_cycle	0.96470863
74	MP0005535_abnormal_body_temperature	0.93852010
75	MP0001502_abnormal_circadian_rhythm	0.93714264
76	MP0002876_abnormal_thyroid_physiology	0.92443393
77	MP0002069_abnormal_eating/drinking_beha	0.91962019
78	MP0006035_abnormal_mitochondrial_morpho	0.91062111
79	MP0004133_heterotaxia	0.89261028
80	MP0003283_abnormal_digestive_organ	0.87887031
81	MP0009780_abnormal_chondrocyte_physiolo	0.86405353
82	MP0004742_abnormal_vestibular_system	0.85638981
83	MP0002752_abnormal_somatic_nervous	0.83355539
84	MP0001963_abnormal_hearing_physiology	0.83252165
85	MP0002234_abnormal_pharynx_morphology	0.82030364
86	MP0003183_abnormal_peptide_metabolism	0.81172126
87	MP0003631_nervous_system_phenotype	0.79183274
88	MP0003698_abnormal_male_reproductive	0.78238290
89	MP0004147_increased_porphyrin_level	0.75631600
90	MP0005084_abnormal_gallbladder_morpholo	0.75551266
91	MP0004484_altered_response_of	0.74234362
92	MP0002152_abnormal_brain_morphology	0.73778590
93	MP0006292_abnormal_olfactory_placode	0.73307235
94	MP0004145_abnormal_muscle_electrophysio	0.73129143
95	MP0000026_abnormal_inner_ear	0.71453322
96	MP0005410_abnormal_fertilization	0.69718505
97	MP0002751_abnormal_autonomic_nervous	0.67500259
98	MP0002163_abnormal_gland_morphology	0.65952897
99	MP0002090_abnormal_vision	0.65742101
100	MP0002332_abnormal_exercise_endurance	0.65723794

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	4.56081996
2	Febrile seizures (HP:0002373)	4.45449713
3	Epileptic encephalopathy (HP:0200134)	3.62949012
4	Medial flaring of the eyebrow (HP:0010747)	3.60433370
5	Atonic seizures (HP:0010819)	3.45792547
6	Hyperventilation (HP:0002883)	3.44391751
7	Gait imbalance (HP:0002141)	3.41236085
8	Focal seizures (HP:0007359)	3.34418372
9	Progressive cerebellar ataxia (HP:0002073)	3.34218891
10	Congenital primary aphakia (HP:0007707)	3.08513588
11	Hemiparesis (HP:0001269)	3.05628988
12	Type II lissencephaly (HP:0007260)	3.04851098
13	Lissencephaly (HP:0001339)	3.01813433
14	Nephrogenic diabetes insipidus (HP:0009806)	2.97582056
15	Genetic anticipation (HP:0003743)	2.96836470
16	Pancreatic fibrosis (HP:0100732)	2.94076373
17	Progressive inability to walk (HP:0002505)	2.91192290
18	Gaze-evoked nystagmus (HP:0000640)	2.90055322
19	Epileptiform EEG discharges (HP:0011182)	2.88564563
20	Myokymia (HP:0002411)	2.87652186
21	Hypsarrhythmia (HP:0002521)	2.86798596
22	EEG with generalized epileptiform discharges (HP:0011198)	2.86654090
23	Dialeptic seizures (HP:0011146)	2.86257397
24	Nephronophthisis (HP:0000090)	2.80779088
25	Absent speech (HP:0001344)	2.78700338
26	Pancreatic cysts (HP:0001737)	2.78641370
27	Abnormality of the renal cortex (HP:0011035)	2.66361589
28	Absence seizures (HP:0002121)	2.66349117
29	Genital tract atresia (HP:0001827)	2.63909156
30	Urinary urgency (HP:0000012)	2.63804445
31	Ankle clonus (HP:0011448)	2.59751276
32	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.58714037
33	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.58714037
34	Congenital stationary night blindness (HP:0007642)	2.56933605
35	Molar tooth sign on MRI (HP:0002419)	2.56278462
36	Abnormality of midbrain morphology (HP:0002418)	2.56278462
37	Anterior segment dysgenesis (HP:0007700)	2.54342049
38	Spastic gait (HP:0002064)	2.50166890
39	Postural instability (HP:0002172)	2.50028126
40	Urinary bladder sphincter dysfunction (HP:0002839)	2.49147427
41	Generalized tonic-clonic seizures (HP:0002069)	2.48918521
42	Limb dystonia (HP:0002451)	2.46870791
43	True hermaphroditism (HP:0010459)	2.46466715
44	Renal cortical cysts (HP:0000803)	2.46220536
45	Inability to walk (HP:0002540)	2.46186607
46	Abnormality of the renal medulla (HP:0100957)	2.44274366
47	Retinal dysplasia (HP:0007973)	2.43979630
48	Polyphagia (HP:0002591)	2.40913788
49	Vaginal atresia (HP:0000148)	2.39488322
50	Broad-based gait (HP:0002136)	2.38322637
51	Pachygyria (HP:0001302)	2.38081157
52	Protruding tongue (HP:0010808)	2.35784532
53	Abnormal drinking behavior (HP:0030082)	2.33330821
54	Polydipsia (HP:0001959)	2.33330821
55	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.32011249
56	Hypoplasia of the fovea (HP:0007750)	2.32011249
57	Hypothermia (HP:0002045)	2.28545647
58	Amyotrophic lateral sclerosis (HP:0007354)	2.27427461
59	Status epilepticus (HP:0002133)	2.26510917
60	Drooling (HP:0002307)	2.25853327
61	Lower limb muscle weakness (HP:0007340)	2.24831545
62	Abnormality of the corticospinal tract (HP:0002492)	2.24737089
63	Action tremor (HP:0002345)	2.18264588
64	Ketoacidosis (HP:0001993)	2.17859905
65	Dyskinesia (HP:0100660)	2.13563082
66	Chronic hepatic failure (HP:0100626)	2.10285902
67	Excessive salivation (HP:0003781)	2.09387004
68	Abnormality of the labia minora (HP:0012880)	2.08524856
69	Spastic tetraplegia (HP:0002510)	2.06803948
70	Abnormal eating behavior (HP:0100738)	2.03395266
71	Specific learning disability (HP:0001328)	2.01672049
72	Poor eye contact (HP:0000817)	2.01103563
73	Muscular hypotonia of the trunk (HP:0008936)	1.97980781
74	Large for gestational age (HP:0001520)	1.97460830
75	Poor coordination (HP:0002370)	1.96302597
76	Agitation (HP:0000713)	1.93304049
77	Supranuclear gaze palsy (HP:0000605)	1.92456063
78	Severe muscular hypotonia (HP:0006829)	1.90538456
79	Intention tremor (HP:0002080)	1.87929314
80	Generalized myoclonic seizures (HP:0002123)	1.87753385
81	Optic nerve hypoplasia (HP:0000609)	1.86977170
82	Hip dysplasia (HP:0001385)	1.86548526
83	Abnormality of the fovea (HP:0000493)	1.85217582
84	Amblyopia (HP:0000646)	1.84880506
85	Increased circulating renin level (HP:0000848)	1.83318506
86	Polyuria (HP:0000103)	1.82322677
87	Esotropia (HP:0000565)	1.77771018
88	Widely spaced teeth (HP:0000687)	1.77384843
89	Failure to thrive in infancy (HP:0001531)	1.75425336
90	Ketosis (HP:0001946)	1.75406688
91	Morphological abnormality of the pyramidal tract (HP:0002062)	1.74746150
92	Fetal akinesia sequence (HP:0001989)	1.73339391
93	Postaxial hand polydactyly (HP:0001162)	1.73315493
94	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.72632690
95	Hypoplasia of the brainstem (HP:0002365)	1.72632690
96	Hypoglycemic coma (HP:0001325)	1.71836354
97	Dysdiadochokinesis (HP:0002075)	1.71617994
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.71100384
99	Hypomagnesemia (HP:0002917)	1.70714283
100	Paraplegia (HP:0010550)	1.69891105

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	5.45896550
2	MARK1	3.68065169
3	MAP3K4	3.61482298
4	CASK	3.31558633
5	MAP4K2	3.24809389
6	FRK	3.17736376
7	MAP2K7	2.80556400
8	MAPK13	2.37989901
9	BCR	2.33801659
10	EPHA4	2.28313355
11	NTRK3	2.14583757
12	WNK3	1.95358764
13	DAPK2	1.95105514
14	TRIM28	1.94221317
15	MAP2K4	1.76548954
16	NTRK2	1.66937156
17	ADRBK2	1.63080125
18	CDK19	1.50308053
19	ERBB3	1.48188178
20	PAK3	1.48133104
21	PRKCG	1.38812328
22	SIK2	1.38378161
23	CAMKK2	1.28280303
24	TAOK3	1.24080468
25	DYRK2	1.23442177
26	MINK1	1.23350033
27	UHMK1	1.19908394
28	OXSR1	1.18300818
29	BRD4	1.16971948
30	PRKCE	1.16808857
31	GRK1	1.16075821
32	CSNK1G2	1.15604770
33	DYRK1A	1.11668884
34	INSRR	1.11459137
35	PLK2	1.11392096
36	CDK5	1.07391184
37	PHKG2	1.05529281
38	PHKG1	1.05529281
39	BMPR1B	1.02368970
40	PAK6	0.94249365
41	CSNK1G3	0.93969778
42	CSNK1A1L	0.90801652
43	MAP2K6	0.89601138
44	CAMK2A	0.88000036
45	SGK494	0.85462211
46	SGK223	0.85462211
47	SGK2	0.83625050
48	AKT3	0.82072334
49	CSNK1G1	0.79867965
50	KSR1	0.77320485
51	STK38	0.76577322
52	PIK3CA	0.75730873
53	FER	0.74064102
54	ACVR1B	0.73838091
55	MAP3K9	0.72185281
56	ADRBK1	0.68438962
57	PTK2B	0.67957480
58	BCKDK	0.66973026
59	STK38L	0.66571566
60	PRKCZ	0.66110598
61	CAMKK1	0.62790226
62	MAP3K6	0.62230068
63	CAMK1	0.61217545
64	CAMK4	0.60194936
65	SIK3	0.57817220
66	NUAK1	0.56266193
67	STK11	0.56181549
68	GRK5	0.55136863
69	FGFR2	0.54991288
70	NEK6	0.53837627
71	MAP3K5	0.53815090
72	CAMK2B	0.53519117
73	RPS6KA4	0.53142181
74	PNCK	0.52129037
75	PRKACA	0.49893500
76	TAOK1	0.48305238
77	PRKAA1	0.46902899
78	CDK14	0.44974972
79	FLT3	0.44509283
80	PASK	0.42569625
81	CSNK1A1	0.42527505
82	SGK1	0.42264355
83	PKN1	0.40848232
84	CDK18	0.40631104
85	MAP3K12	0.39946898
86	EPHA3	0.38983835
87	CAMK2D	0.36725204
88	MUSK	0.35341507
89	WNK4	0.35322582
90	CDK3	0.34912895
91	ABL1	0.33647440
92	MAP3K7	0.33610756
93	STK39	0.33490149
94	DAPK1	0.33222462
95	CDK15	0.33214469
96	TNIK	0.32376296
97	PRKCH	0.31912545
98	RPS6KA3	0.31720173
99	ZAK	0.31581290
100	RPS6KA5	0.31568988

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.66377301
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.54056968
3	Phototransduction_Homo sapiens_hsa04744	3.14435999
4	GABAergic synapse_Homo sapiens_hsa04727	3.00698549
5	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.86499776
6	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.66228936
7	Morphine addiction_Homo sapiens_hsa05032	2.55492368
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.44523428
9	Butanoate metabolism_Homo sapiens_hsa00650	2.26298861
10	Circadian entrainment_Homo sapiens_hsa04713	2.13083063
11	Insulin secretion_Homo sapiens_hsa04911	2.09828280
12	Glutamatergic synapse_Homo sapiens_hsa04724	2.01870194
13	Collecting duct acid secretion_Homo sapiens_hsa04966	1.94725750
14	Dopaminergic synapse_Homo sapiens_hsa04728	1.92146480
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.91510296
16	Amphetamine addiction_Homo sapiens_hsa05031	1.83686364
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.81735059
18	Taste transduction_Homo sapiens_hsa04742	1.79428957
19	Cocaine addiction_Homo sapiens_hsa05030	1.66473880
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.62217340
21	Regulation of autophagy_Homo sapiens_hsa04140	1.61945822
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.58180046
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.43904441
24	Protein export_Homo sapiens_hsa03060	1.42956697
25	Olfactory transduction_Homo sapiens_hsa04740	1.42221810
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.30072173
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.28907938
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.28797266
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.27895792
30	Salivary secretion_Homo sapiens_hsa04970	1.26351532
31	Serotonergic synapse_Homo sapiens_hsa04726	1.25969930
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20050917
33	Long-term depression_Homo sapiens_hsa04730	1.19970516
34	Parkinsons disease_Homo sapiens_hsa05012	1.19946473
35	Type II diabetes mellitus_Homo sapiens_hsa04930	1.18250430
36	Circadian rhythm_Homo sapiens_hsa04710	1.13817358
37	Basal transcription factors_Homo sapiens_hsa03022	1.11683281
38	Peroxisome_Homo sapiens_hsa04146	1.08572941
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.08088855
40	Renin secretion_Homo sapiens_hsa04924	1.05215799
41	Gastric acid secretion_Homo sapiens_hsa04971	1.04370016
42	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.97269291
43	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.96651470
44	Calcium signaling pathway_Homo sapiens_hsa04020	0.96454714
45	beta-Alanine metabolism_Homo sapiens_hsa00410	0.93233104
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.90502848
47	Cholinergic synapse_Homo sapiens_hsa04725	0.89885687
48	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.89793552
49	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.84468786
50	cAMP signaling pathway_Homo sapiens_hsa04024	0.84273153
51	Alzheimers disease_Homo sapiens_hsa05010	0.78373996
52	Long-term potentiation_Homo sapiens_hsa04720	0.78366534
53	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.78011681
54	ABC transporters_Homo sapiens_hsa02010	0.75099308
55	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.74792184
56	Vibrio cholerae infection_Homo sapiens_hsa05110	0.70309932
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67909826
58	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.67145073
59	Selenocompound metabolism_Homo sapiens_hsa00450	0.64125848
60	Axon guidance_Homo sapiens_hsa04360	0.60963870
61	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.60638659
62	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.59399212
63	Huntingtons disease_Homo sapiens_hsa05016	0.57717111
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.57060183
65	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.56973514
66	Nitrogen metabolism_Homo sapiens_hsa00910	0.54792376
67	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.53703437
68	RNA degradation_Homo sapiens_hsa03018	0.53497908
69	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53202005
70	Type I diabetes mellitus_Homo sapiens_hsa04940	0.52861447
71	Propanoate metabolism_Homo sapiens_hsa00640	0.52382510
72	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.52139220
73	Oocyte meiosis_Homo sapiens_hsa04114	0.51799690
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.50078128
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46965379
76	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.46779886
77	Ras signaling pathway_Homo sapiens_hsa04014	0.45834275
78	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.45826260
79	Caffeine metabolism_Homo sapiens_hsa00232	0.45319162
80	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.43930280
81	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.42459001
82	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41806346
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.41483028
84	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.39310658
85	Fanconi anemia pathway_Homo sapiens_hsa03460	0.35955500
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34239601
87	Pancreatic secretion_Homo sapiens_hsa04972	0.34094733
88	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.33807750
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33405492
90	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.32245786
91	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.30541689
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.29944554
93	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.27575652
94	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.24862215
95	RNA polymerase_Homo sapiens_hsa03020	0.23924010
96	Metabolic pathways_Homo sapiens_hsa01100	0.23072856
97	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.22015060
98	MAPK signaling pathway_Homo sapiens_hsa04010	0.20371694
99	Alcoholism_Homo sapiens_hsa05034	0.20036348
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.19956442

ZNF540

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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