ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	4.28160804
2	protein neddylation (GO:0045116)	4.12396697
3	behavioral response to nicotine (GO:0035095)	3.86417298
4	presynaptic membrane assembly (GO:0097105)	3.85276187
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.61862708
6	nucleobase catabolic process (GO:0046113)	3.57147524
7	regulation of cilium movement (GO:0003352)	3.34835105
8	postsynaptic membrane organization (GO:0001941)	3.34746826
9	neuronal action potential propagation (GO:0019227)	3.32909217
10	nonmotile primary cilium assembly (GO:0035058)	3.31908870
11	presynaptic membrane organization (GO:0097090)	3.27241176
12	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.19453263
13	regulation of translation, ncRNA-mediated (GO:0045974)	3.19453263
14	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.19453263
15	neuron cell-cell adhesion (GO:0007158)	3.17207770
16	platelet dense granule organization (GO:0060155)	3.13771601
17	regulation of meiosis I (GO:0060631)	3.13131251
18	gamma-aminobutyric acid transport (GO:0015812)	3.10918534
19	epithelial cilium movement (GO:0003351)	3.05023356
20	kidney morphogenesis (GO:0060993)	3.04066925
21	negative regulation of heart rate (GO:0010459)	3.03670999
22	regulation of sarcomere organization (GO:0060297)	2.96647500
23	negative regulation of response to food (GO:0032096)	2.95352537
24	negative regulation of appetite (GO:0032099)	2.95352537
25	neural tube formation (GO:0001841)	2.93559976
26	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.91863285
27	regulation of gene silencing by RNA (GO:0060966)	2.88663983
28	regulation of posttranscriptional gene silencing (GO:0060147)	2.88663983
29	regulation of gene silencing by miRNA (GO:0060964)	2.88663983
30	somite development (GO:0061053)	2.82758335
31	dopamine transport (GO:0015872)	2.79359724
32	protein polyglutamylation (GO:0018095)	2.76771819
33	negative regulation of protein localization to cell surface (GO:2000009)	2.76560428
34	transmission of nerve impulse (GO:0019226)	2.76553094
35	retinal cone cell development (GO:0046549)	2.74669023
36	neuronal action potential (GO:0019228)	2.72682792
37	adaptation of signaling pathway (GO:0023058)	2.72644844
38	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.70386988
39	water-soluble vitamin biosynthetic process (GO:0042364)	2.69115109
40	cilium movement (GO:0003341)	2.68269260
41	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.67966919
42	centriole replication (GO:0007099)	2.67666999
43	photoreceptor cell maintenance (GO:0045494)	2.64415561
44	cilium morphogenesis (GO:0060271)	2.59834862
45	DNA double-strand break processing (GO:0000729)	2.58462079
46	piRNA metabolic process (GO:0034587)	2.58024210
47	cilium organization (GO:0044782)	2.57920925
48	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.57776301
49	NADH dehydrogenase complex assembly (GO:0010257)	2.57776301
50	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.57776301
51	axoneme assembly (GO:0035082)	2.57442088
52	detection of light stimulus involved in sensory perception (GO:0050962)	2.55827570
53	detection of light stimulus involved in visual perception (GO:0050908)	2.55827570
54	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.55817500
55	cilium assembly (GO:0042384)	2.55695239
56	regulation of hippo signaling (GO:0035330)	2.54932584
57	regulation of microtubule-based movement (GO:0060632)	2.54474504
58	positive regulation of meiosis (GO:0045836)	2.54469045
59	response to pheromone (GO:0019236)	2.50839003
60	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.49859286
61	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.49694981
62	microtubule depolymerization (GO:0007019)	2.48828346
63	spinal cord motor neuron differentiation (GO:0021522)	2.48421267
64	kynurenine metabolic process (GO:0070189)	2.47143747
65	C4-dicarboxylate transport (GO:0015740)	2.47105918
66	sulfation (GO:0051923)	2.46593921
67	indolalkylamine metabolic process (GO:0006586)	2.46504825
68	positive regulation of protein homodimerization activity (GO:0090073)	2.44843437
69	indole-containing compound catabolic process (GO:0042436)	2.44724355
70	indolalkylamine catabolic process (GO:0046218)	2.44724355
71	tryptophan catabolic process (GO:0006569)	2.44724355
72	male meiosis (GO:0007140)	2.43278180
73	single strand break repair (GO:0000012)	2.43129520
74	regulation of action potential (GO:0098900)	2.43031078
75	prenylation (GO:0097354)	2.42528271
76	protein prenylation (GO:0018342)	2.42528271
77	protein localization to synapse (GO:0035418)	2.42233475
78	glycerophospholipid catabolic process (GO:0046475)	2.42116360
79	positive regulation of amino acid transport (GO:0051957)	2.41350098
80	tachykinin receptor signaling pathway (GO:0007217)	2.41269356
81	otic vesicle formation (GO:0030916)	2.36360334
82	regulation of collateral sprouting (GO:0048670)	2.36170542
83	cilium or flagellum-dependent cell motility (GO:0001539)	2.36006274
84	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.35762786
85	positive regulation of meiotic cell cycle (GO:0051446)	2.34705827
86	limb bud formation (GO:0060174)	2.34659726
87	replication fork processing (GO:0031297)	2.34002735
88	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.33583557
89	neurotransmitter-gated ion channel clustering (GO:0072578)	2.32947467
90	protein complex biogenesis (GO:0070271)	2.32821312
91	cellular ketone body metabolic process (GO:0046950)	2.32773827
92	amine catabolic process (GO:0009310)	2.31486226
93	cellular biogenic amine catabolic process (GO:0042402)	2.31486226
94	L-fucose catabolic process (GO:0042355)	2.31023132
95	fucose catabolic process (GO:0019317)	2.31023132
96	L-fucose metabolic process (GO:0042354)	2.31023132
97	synapse assembly (GO:0007416)	2.30237199
98	intraciliary transport (GO:0042073)	2.30157526
99	vocalization behavior (GO:0071625)	2.29397183
100	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.29197962

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.57407842
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.31315372
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.31040189
4	VDR_22108803_ChIP-Seq_LS180_Human	2.90544357
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.86258336
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.75475476
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.72013996
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.57154462
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.49314313
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.44281672
11	P300_19829295_ChIP-Seq_ESCs_Human	2.30917301
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.29182624
13	EWS_26573619_Chip-Seq_HEK293_Human	2.29131035
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.25027602
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.18338020
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.18156617
17	FUS_26573619_Chip-Seq_HEK293_Human	2.10244042
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.93728694
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.88721543
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.81601654
21	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.79458893
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79268963
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.78858295
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.78814327
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.78115470
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.73028610
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.72800908
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.69166313
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68346738
30	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.66467056
31	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.61599814
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.60600787
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.58479077
34	STAT3_23295773_ChIP-Seq_U87_Human	1.55592843
35	AR_25329375_ChIP-Seq_VCAP_Human	1.54100370
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49004916
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.48115728
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.47568024
39	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.46495402
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.44685431
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43783530
42	TCF4_23295773_ChIP-Seq_U87_Human	1.43399003
43	RNF2_27304074_Chip-Seq_NSC_Mouse	1.42023748
44	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.41285952
45	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40115180
46	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.40115180
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38654832
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38442249
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.38442249
50	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.38250221
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36710278
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.36612056
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35280869
54	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.33401905
55	AR_21572438_ChIP-Seq_LNCaP_Human	1.33022065
56	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.29948396
57	REST_21632747_ChIP-Seq_MESCs_Mouse	1.27222915
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27134082
59	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.27120586
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.26420777
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.25801570
62	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.24911458
63	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.23152347
64	P53_22387025_ChIP-Seq_ESCs_Mouse	1.23071949
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22974148
66	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22135119
67	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.19597730
68	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19474598
69	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.19248567
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19013320
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19013320
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18998759
73	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.18358956
74	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17958296
75	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.16964969
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13449148
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13303910
78	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.12970948
79	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.12405219
80	ELK1_19687146_ChIP-ChIP_HELA_Human	1.09732696
81	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.09714143
82	JUN_21703547_ChIP-Seq_K562_Human	1.09579567
83	TP53_22573176_ChIP-Seq_HFKS_Human	1.07879383
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07817962
85	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.07309995
86	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06607368
87	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.06233598
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05943302
89	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04977123
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04877748
91	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04352561
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04352561
93	MYC_18940864_ChIP-ChIP_HL60_Human	1.04282162
94	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03867980
95	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.01944811
96	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.01890008
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01774058
98	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.01596855
99	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.01136135
100	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99899350

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.71486418
2	MP0003136_yellow_coat_color	3.00253727
3	MP0002736_abnormal_nociception_after	2.53287852
4	MP0003880_abnormal_central_pattern	2.50404278
5	MP0006276_abnormal_autonomic_nervous	2.37661210
6	MP0001968_abnormal_touch/_nociception	2.37234107
7	MP0002102_abnormal_ear_morphology	2.27376016
8	MP0000569_abnormal_digit_pigmentation	2.16792992
9	MP0006292_abnormal_olfactory_placode	2.15822433
10	MP0003787_abnormal_imprinting	2.15549264
11	MP0005551_abnormal_eye_electrophysiolog	2.05924607
12	MP0001529_abnormal_vocalization	1.99423112
13	MP0001984_abnormal_olfaction	1.97948393
14	MP0002638_abnormal_pupillary_reflex	1.97764638
15	MP0003122_maternal_imprinting	1.89883672
16	MP0004142_abnormal_muscle_tone	1.83815829
17	MP0009745_abnormal_behavioral_response	1.78286167
18	MP0002938_white_spotting	1.76410854
19	MP0009046_muscle_twitch	1.76170729
20	MP0001486_abnormal_startle_reflex	1.75010079
21	MP0005084_abnormal_gallbladder_morpholo	1.70366167
22	MP0003718_maternal_effect	1.67937894
23	MP0002735_abnormal_chemical_nociception	1.61513592
24	MP0000631_abnormal_neuroendocrine_gland	1.57826160
25	MP0002272_abnormal_nervous_system	1.57538889
26	MP0004133_heterotaxia	1.51731753
27	MP0003635_abnormal_synaptic_transmissio	1.51175609
28	MP0000778_abnormal_nervous_system	1.49386116
29	MP0003121_genomic_imprinting	1.48200679
30	MP0004215_abnormal_myocardial_fiber	1.47743313
31	MP0005646_abnormal_pituitary_gland	1.45289723
32	MP0002837_dystrophic_cardiac_calcinosis	1.43528410
33	MP0001485_abnormal_pinna_reflex	1.43376742
34	MP0004859_abnormal_synaptic_plasticity	1.41908519
35	MP0002572_abnormal_emotion/affect_behav	1.40045458
36	MP0005645_abnormal_hypothalamus_physiol	1.39934816
37	MP0005187_abnormal_penis_morphology	1.39232066
38	MP0005253_abnormal_eye_physiology	1.38684900
39	MP0002234_abnormal_pharynx_morphology	1.38672072
40	MP0006072_abnormal_retinal_apoptosis	1.35882672
41	MP0008872_abnormal_physiological_respon	1.34927409
42	MP0002067_abnormal_sensory_capabilities	1.34438552
43	MP0003195_calcinosis	1.33992315
44	MP0002734_abnormal_mechanical_nocicepti	1.33746704
45	MP0003119_abnormal_digestive_system	1.30788385
46	MP0002064_seizures	1.28718963
47	MP0008789_abnormal_olfactory_epithelium	1.27031997
48	MP0004270_analgesia	1.26540442
49	MP0003941_abnormal_skin_development	1.25119783
50	MP0001970_abnormal_pain_threshold	1.22156814
51	MP0002063_abnormal_learning/memory/cond	1.21748505
52	MP0002557_abnormal_social/conspecific_i	1.20356555
53	MP0002733_abnormal_thermal_nociception	1.19208647
54	MP0001293_anophthalmia	1.18407551
55	MP0002653_abnormal_ependyma_morphology	1.14988923
56	MP0003890_abnormal_embryonic-extraembry	1.14120550
57	MP0004885_abnormal_endolymph	1.13962583
58	MP0002751_abnormal_autonomic_nervous	1.12513881
59	MP0008058_abnormal_DNA_repair	1.12124857
60	MP0005410_abnormal_fertilization	1.10544880
61	MP0004924_abnormal_behavior	1.09889253
62	MP0005386_behavior/neurological_phenoty	1.09889253
63	MP0003011_delayed_dark_adaptation	1.09284191
64	MP0002254_reproductive_system_inflammat	1.08017155
65	MP0000230_abnormal_systemic_arterial	1.06785027
66	MP0000427_abnormal_hair_cycle	1.05603980
67	MP0005394_taste/olfaction_phenotype	1.03074117
68	MP0005499_abnormal_olfactory_system	1.03074117
69	MP0004084_abnormal_cardiac_muscle	1.02786827
70	MP0000647_abnormal_sebaceous_gland	1.01138514
71	MP0000372_irregular_coat_pigmentation	1.00924233
72	MP0005367_renal/urinary_system_phenotyp	1.00187752
73	MP0000516_abnormal_urinary_system	1.00187752
74	MP0004085_abnormal_heartbeat	0.99155473
75	MP0005174_abnormal_tail_pigmentation	0.96925636
76	MP0003567_abnormal_fetal_cardiomyocyte	0.96421631
77	MP0001986_abnormal_taste_sensitivity	0.95844734
78	MP0001501_abnormal_sleep_pattern	0.94918191
79	MP0002752_abnormal_somatic_nervous	0.94696248
80	MP0003698_abnormal_male_reproductive	0.93213975
81	MP0003646_muscle_fatigue	0.92346221
82	MP0008775_abnormal_heart_ventricle	0.92084580
83	MP0003937_abnormal_limbs/digits/tail_de	0.91848715
84	MP0004043_abnormal_pH_regulation	0.90802294
85	MP0008004_abnormal_stomach_pH	0.89469749
86	MP0004742_abnormal_vestibular_system	0.89061489
87	MP0002090_abnormal_vision	0.88967776
88	MP0005195_abnormal_posterior_eye	0.88785038
89	MP0004147_increased_porphyrin_level	0.88703212
90	MP0004145_abnormal_muscle_electrophysio	0.88648532
91	MP0008995_early_reproductive_senescence	0.88140058
92	MP0009697_abnormal_copulation	0.85669263
93	MP0001188_hyperpigmentation	0.84790501
94	MP0010386_abnormal_urinary_bladder	0.83272969
95	MP0002882_abnormal_neuron_morphology	0.81627735
96	MP0005423_abnormal_somatic_nervous	0.81299066
97	MP0002233_abnormal_nose_morphology	0.81095924
98	MP0000955_abnormal_spinal_cord	0.80384712
99	MP0002184_abnormal_innervation	0.80356648
100	MP0001299_abnormal_eye_distance/	0.79164328

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.96050554
2	Hyperventilation (HP:0002883)	3.81908745
3	Pancreatic fibrosis (HP:0100732)	3.69836257
4	Abnormality of midbrain morphology (HP:0002418)	3.59487479
5	Molar tooth sign on MRI (HP:0002419)	3.59487479
6	Medial flaring of the eyebrow (HP:0010747)	3.38694513
7	True hermaphroditism (HP:0010459)	3.37264917
8	Nephronophthisis (HP:0000090)	3.19076431
9	Gait imbalance (HP:0002141)	3.10000324
10	Abnormality of the renal cortex (HP:0011035)	2.97096552
11	Congenital primary aphakia (HP:0007707)	2.88623514
12	Intestinal atresia (HP:0011100)	2.88509983
13	Nephrogenic diabetes insipidus (HP:0009806)	2.76492470
14	Genital tract atresia (HP:0001827)	2.75862036
15	Abnormality of the renal medulla (HP:0100957)	2.75539720
16	Abnormality of the labia minora (HP:0012880)	2.66972877
17	Vaginal atresia (HP:0000148)	2.63565540
18	Renal cortical cysts (HP:0000803)	2.62644988
19	Lissencephaly (HP:0001339)	2.60538204
20	Optic nerve hypoplasia (HP:0000609)	2.59574327
21	Congenital stationary night blindness (HP:0007642)	2.56867360
22	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.52471081
23	Abnormality of alanine metabolism (HP:0010916)	2.52471081
24	Hyperalaninemia (HP:0003348)	2.52471081
25	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.52343446
26	Type II lissencephaly (HP:0007260)	2.43849293
27	Gaze-evoked nystagmus (HP:0000640)	2.43186837
28	Inability to walk (HP:0002540)	2.41528081
29	Broad-based gait (HP:0002136)	2.40434257
30	Febrile seizures (HP:0002373)	2.37209939
31	Polyphagia (HP:0002591)	2.33850509
32	Progressive inability to walk (HP:0002505)	2.33465637
33	Abolished electroretinogram (ERG) (HP:0000550)	2.32641147
34	Drooling (HP:0002307)	2.27717869
35	Poor coordination (HP:0002370)	2.27497720
36	Cystic liver disease (HP:0006706)	2.17211739
37	Septo-optic dysplasia (HP:0100842)	2.16927150
38	Congenital, generalized hypertrichosis (HP:0004540)	2.15421044
39	Focal motor seizures (HP:0011153)	2.14400278
40	Methylmalonic acidemia (HP:0002912)	2.12038311
41	Pachygyria (HP:0001302)	2.11511259
42	Attenuation of retinal blood vessels (HP:0007843)	2.10894040
43	Decreased central vision (HP:0007663)	2.10273679
44	Protruding tongue (HP:0010808)	2.08596106
45	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.07549512
46	Increased mean platelet volume (HP:0011877)	2.07312060
47	Gastrointestinal atresia (HP:0002589)	2.06836214
48	Tubular atrophy (HP:0000092)	2.05757154
49	Keratoconus (HP:0000563)	2.05136820
50	Increased corneal curvature (HP:0100692)	2.05136820
51	Pendular nystagmus (HP:0012043)	2.04442022
52	Hypothermia (HP:0002045)	2.03254035
53	Chronic hepatic failure (HP:0100626)	2.00833126
54	Atonic seizures (HP:0010819)	2.00762297
55	Calf muscle hypertrophy (HP:0008981)	1.98597775
56	Large for gestational age (HP:0001520)	1.98161697
57	Excessive salivation (HP:0003781)	1.98142396
58	Hemiparesis (HP:0001269)	1.97043701
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.96744804
60	Progressive cerebellar ataxia (HP:0002073)	1.96406939
61	Hyperglycinemia (HP:0002154)	1.95679479
62	Absent speech (HP:0001344)	1.89918318
63	Thyroid-stimulating hormone excess (HP:0002925)	1.89599764
64	Anencephaly (HP:0002323)	1.89499038
65	Postaxial hand polydactyly (HP:0001162)	1.89234086
66	Bile duct proliferation (HP:0001408)	1.89180045
67	Abnormal biliary tract physiology (HP:0012439)	1.89180045
68	Bilateral microphthalmos (HP:0007633)	1.88936437
69	Male pseudohermaphroditism (HP:0000037)	1.88825812
70	Sclerocornea (HP:0000647)	1.86941617
71	Abnormal ciliary motility (HP:0012262)	1.85627460
72	Congenital hepatic fibrosis (HP:0002612)	1.82691765
73	Epileptic encephalopathy (HP:0200134)	1.81916925
74	Fair hair (HP:0002286)	1.81736909
75	Narrow forehead (HP:0000341)	1.79691042
76	Specific learning disability (HP:0001328)	1.79186820
77	Abnormal rod and cone electroretinograms (HP:0008323)	1.78447081
78	Growth hormone deficiency (HP:0000824)	1.78308163
79	Focal seizures (HP:0007359)	1.77490700
80	Acute necrotizing encephalopathy (HP:0006965)	1.76863051
81	Menorrhagia (HP:0000132)	1.75195385
82	Dialeptic seizures (HP:0011146)	1.75120763
83	Polydipsia (HP:0001959)	1.75004135
84	Abnormal drinking behavior (HP:0030082)	1.75004135
85	Colon cancer (HP:0003003)	1.73615392
86	Muscle hypertrophy of the lower extremities (HP:0008968)	1.71980029
87	Hyperlipoproteinemia (HP:0010980)	1.71758849
88	Methylmalonic aciduria (HP:0012120)	1.71555661
89	Abnormal respiratory epithelium morphology (HP:0012253)	1.71029704
90	Abnormal respiratory motile cilium morphology (HP:0005938)	1.71029704
91	Acute encephalopathy (HP:0006846)	1.71024365
92	Broad foot (HP:0001769)	1.70551939
93	Pancreatic islet-cell hyperplasia (HP:0004510)	1.69209525
94	Cerebellar dysplasia (HP:0007033)	1.67691733
95	Postaxial foot polydactyly (HP:0001830)	1.66717391
96	Neuroendocrine neoplasm (HP:0100634)	1.66241855
97	Astigmatism (HP:0000483)	1.64918345
98	Hypsarrhythmia (HP:0002521)	1.64856218
99	Hyperglycinuria (HP:0003108)	1.64717679
100	Progressive macrocephaly (HP:0004481)	1.64435909

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.63427420
2	WNK3	3.52449227
3	CASK	2.84900870
4	TRIM28	2.61102844
5	PNCK	2.55818779
6	BMPR1B	2.41429539
7	NUAK1	2.38369463
8	MARK1	2.27493844
9	TNIK	2.23473238
10	ACVR1B	2.09979165
11	MAP4K2	2.07484918
12	MAPK13	2.01438005
13	MAP3K4	1.92913620
14	INSRR	1.92039947
15	ADRBK2	1.87452800
16	MST4	1.79064812
17	DYRK2	1.77413458
18	ZAK	1.75229210
19	GRK1	1.65442228
20	NTRK3	1.52384557
21	MKNK2	1.47415409
22	BCR	1.43863021
23	MAP2K7	1.35260643
24	WNK4	1.34232343
25	PAK3	1.31214666
26	PLK2	1.30585154
27	STK38L	1.18218207
28	PINK1	1.13556418
29	PRKCG	1.07465907
30	PLK3	1.07263911
31	EPHA3	1.04466937
32	TAOK3	1.04229817
33	VRK1	1.03231218
34	TSSK6	1.00810464
35	PRKCE	0.96342152
36	MKNK1	0.94920462
37	DAPK2	0.94298969
38	NTRK2	0.93368947
39	STK3	0.92016013
40	AKT3	0.91608929
41	PTK2B	0.87933193
42	EPHA4	0.87793915
43	PIK3CG	0.87575947
44	TGFBR1	0.81994352
45	ADRBK1	0.81357348
46	CAMK1G	0.79437282
47	ERBB3	0.78718599
48	CSNK1G1	0.78494142
49	CSNK1G2	0.76907404
50	TEC	0.75119207
51	MINK1	0.74157131
52	DYRK3	0.73729714
53	TAF1	0.72400808
54	GRK5	0.71253810
55	STK39	0.71197319
56	FGFR2	0.70533686
57	PIM2	0.70093804
58	SGK2	0.69375091
59	PHKG1	0.69025004
60	PHKG2	0.69025004
61	PKN1	0.68871187
62	EIF2AK1	0.67734373
63	OXSR1	0.63671069
64	DYRK1A	0.62205618
65	OBSCN	0.61750323
66	TLK1	0.59815672
67	DYRK1B	0.58666256
68	NLK	0.56613899
69	STK16	0.56350534
70	CAMK2A	0.55540728
71	BRSK2	0.53514655
72	CSNK1G3	0.53250711
73	TXK	0.51995268
74	IRAK1	0.51564111
75	SGK223	0.49733070
76	SGK494	0.49733070
77	SRPK1	0.48429190
78	FER	0.48020817
79	CSNK1A1L	0.46116522
80	PRKG1	0.45290273
81	CAMK1	0.44858905
82	PLK4	0.44700645
83	PBK	0.43529762
84	TIE1	0.41069581
85	CSNK1D	0.41027252
86	LATS1	0.40259086
87	ERBB2	0.38403405
88	PRKACA	0.38315046
89	CCNB1	0.37897706
90	MYLK	0.37511059
91	WEE1	0.36550289
92	CDK19	0.36065409
93	CDK3	0.35115632
94	MAPK15	0.34844253
95	PRKACB	0.32956003
96	KSR1	0.32105058
97	FLT3	0.31098049
98	CSNK1A1	0.30760277
99	CSNK1E	0.30708288
100	UHMK1	0.29998998

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.46449675
2	Nicotine addiction_Homo sapiens_hsa05033	2.46388669
3	Phototransduction_Homo sapiens_hsa04744	2.45452773
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.33265185
5	Butanoate metabolism_Homo sapiens_hsa00650	2.22485415
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.04246591
7	Oxidative phosphorylation_Homo sapiens_hsa00190	1.96263155
8	Protein export_Homo sapiens_hsa03060	1.92641723
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.82649977
10	Basal transcription factors_Homo sapiens_hsa03022	1.80387948
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.79586731
12	Selenocompound metabolism_Homo sapiens_hsa00450	1.78432394
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.76438448
14	Steroid biosynthesis_Homo sapiens_hsa00100	1.75721242
15	Propanoate metabolism_Homo sapiens_hsa00640	1.71737313
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.70669271
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.69940546
18	RNA polymerase_Homo sapiens_hsa03020	1.65483499
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.65078717
20	Parkinsons disease_Homo sapiens_hsa05012	1.63227506
21	Olfactory transduction_Homo sapiens_hsa04740	1.61800022
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.60879782
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.60627671
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.49825503
25	GABAergic synapse_Homo sapiens_hsa04727	1.48852151
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.45899787
27	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.43573689
28	Morphine addiction_Homo sapiens_hsa05032	1.41598033
29	Taste transduction_Homo sapiens_hsa04742	1.41141068
30	Circadian entrainment_Homo sapiens_hsa04713	1.39943545
31	Homologous recombination_Homo sapiens_hsa03440	1.38003938
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.36241138
33	Serotonergic synapse_Homo sapiens_hsa04726	1.35628476
34	Glutamatergic synapse_Homo sapiens_hsa04724	1.29983571
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.27940933
36	beta-Alanine metabolism_Homo sapiens_hsa00410	1.26098923
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.25986442
38	Huntingtons disease_Homo sapiens_hsa05016	1.23551066
39	Ether lipid metabolism_Homo sapiens_hsa00565	1.18417258
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.18357256
41	Regulation of autophagy_Homo sapiens_hsa04140	1.11655140
42	Insulin secretion_Homo sapiens_hsa04911	1.09449455
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.09324237
44	Caffeine metabolism_Homo sapiens_hsa00232	1.08964637
45	Peroxisome_Homo sapiens_hsa04146	1.07842688
46	RNA degradation_Homo sapiens_hsa03018	1.07338746
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.07057008
48	Collecting duct acid secretion_Homo sapiens_hsa04966	1.05529771
49	Dopaminergic synapse_Homo sapiens_hsa04728	1.01280095
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.98972280
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.97092623
52	Alzheimers disease_Homo sapiens_hsa05010	0.94559112
53	Circadian rhythm_Homo sapiens_hsa04710	0.92143794
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87897550
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85739001
56	Fatty acid elongation_Homo sapiens_hsa00062	0.85351912
57	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.84424814
58	Amphetamine addiction_Homo sapiens_hsa05031	0.82921229
59	Long-term depression_Homo sapiens_hsa04730	0.81010859
60	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.80794846
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.80271303
62	Calcium signaling pathway_Homo sapiens_hsa04020	0.78817524
63	Non-homologous end-joining_Homo sapiens_hsa03450	0.78707684
64	Retinol metabolism_Homo sapiens_hsa00830	0.77349123
65	Cocaine addiction_Homo sapiens_hsa05030	0.76921793
66	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.76233411
67	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.75259324
68	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.74112325
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.73992844
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72399789
71	Purine metabolism_Homo sapiens_hsa00230	0.69379671
72	ABC transporters_Homo sapiens_hsa02010	0.68368318
73	Mismatch repair_Homo sapiens_hsa03430	0.67911063
74	One carbon pool by folate_Homo sapiens_hsa00670	0.67288581
75	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.65164218
76	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.65098956
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64647948
78	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.64435675
79	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.63400099
80	Cholinergic synapse_Homo sapiens_hsa04725	0.62883189
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.61775269
82	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.61703539
83	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.60028530
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.59995967
85	Histidine metabolism_Homo sapiens_hsa00340	0.58039429
86	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.55639930
87	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.52993018
88	Metabolic pathways_Homo sapiens_hsa01100	0.52231170
89	cAMP signaling pathway_Homo sapiens_hsa04024	0.51217637
90	Platelet activation_Homo sapiens_hsa04611	0.51152797
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.50520017
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49595919
93	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.49432395
94	Fatty acid degradation_Homo sapiens_hsa00071	0.49297990
95	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.47379136
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46173253
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45147688
98	Alcoholism_Homo sapiens_hsa05034	0.45077283
99	Hippo signaling pathway_Homo sapiens_hsa04390	0.44992832
100	Salivary secretion_Homo sapiens_hsa04970	0.43260267

ZNF542P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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