ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neural tube formation (GO:0001841)	3.77852486
2	L-fucose catabolic process (GO:0042355)	3.75139944
3	fucose catabolic process (GO:0019317)	3.75139944
4	L-fucose metabolic process (GO:0042354)	3.75139944
5	piRNA metabolic process (GO:0034587)	3.70294105
6	DNA double-strand break processing (GO:0000729)	3.61074371
7	cornea development in camera-type eye (GO:0061303)	3.60487840
8	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.53405729
9	regulation of translation, ncRNA-mediated (GO:0045974)	3.53405729
10	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.53405729
11	protein K11-linked deubiquitination (GO:0035871)	3.50711622
12	replication fork processing (GO:0031297)	3.49283233
13	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.37778598
14	atrial cardiac muscle cell action potential (GO:0086014)	3.35904983
15	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.27103894
16	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.22595321
17	kidney morphogenesis (GO:0060993)	3.22227795
18	response to pheromone (GO:0019236)	3.17640137
19	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.07275275
20	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.07275275
21	regulation of hexokinase activity (GO:1903299)	2.98090497
22	regulation of glucokinase activity (GO:0033131)	2.98090497
23	pyrimidine dimer repair (GO:0006290)	2.95770242
24	rRNA catabolic process (GO:0016075)	2.95342642
25	regulation of meiosis I (GO:0060631)	2.93711819
26	regulation of telomere maintenance (GO:0032204)	2.92690065
27	protein polyglutamylation (GO:0018095)	2.92677656
28	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.92674783
29	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.91113561
30	regulation of DNA endoreduplication (GO:0032875)	2.90819803
31	presynaptic membrane assembly (GO:0097105)	2.88592177
32	water-soluble vitamin biosynthetic process (GO:0042364)	2.87350265
33	pyrimidine nucleobase catabolic process (GO:0006208)	2.86718872
34	recombinational repair (GO:0000725)	2.85876978
35	double-strand break repair via homologous recombination (GO:0000724)	2.85637088
36	cilium morphogenesis (GO:0060271)	2.84990866
37	behavioral response to nicotine (GO:0035095)	2.81093991
38	keratinocyte development (GO:0003334)	2.79140101
39	maturation of 5.8S rRNA (GO:0000460)	2.78747771
40	microtubule anchoring (GO:0034453)	2.77476509
41	DNA methylation involved in gamete generation (GO:0043046)	2.77079710
42	retinal cone cell development (GO:0046549)	2.76950464
43	limb bud formation (GO:0060174)	2.75278547
44	mitotic sister chromatid cohesion (GO:0007064)	2.74752334
45	cellular ketone body metabolic process (GO:0046950)	2.73509076
46	synapsis (GO:0007129)	2.73164475
47	resolution of meiotic recombination intermediates (GO:0000712)	2.72803815
48	regulation of hippo signaling (GO:0035330)	2.71853339
49	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.70955424
50	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.70570393
51	nonmotile primary cilium assembly (GO:0035058)	2.70261446
52	protein localization to cilium (GO:0061512)	2.69841386
53	preassembly of GPI anchor in ER membrane (GO:0016254)	2.66353490
54	establishment of protein localization to Golgi (GO:0072600)	2.63859059
55	pseudouridine synthesis (GO:0001522)	2.62493675
56	DNA-dependent DNA replication (GO:0006261)	2.61462211
57	respiratory chain complex IV assembly (GO:0008535)	2.60187114
58	presynaptic membrane organization (GO:0097090)	2.56876638
59	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.56783968
60	DNA demethylation (GO:0080111)	2.56615254
61	reciprocal DNA recombination (GO:0035825)	2.55763277
62	reciprocal meiotic recombination (GO:0007131)	2.55763277
63	histone mRNA catabolic process (GO:0071044)	2.55171547
64	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.54503432
65	branched-chain amino acid catabolic process (GO:0009083)	2.54335565
66	indolalkylamine metabolic process (GO:0006586)	2.54225849
67	negative regulation of telomere maintenance (GO:0032205)	2.54198615
68	histone H2A acetylation (GO:0043968)	2.54198330
69	protein prenylation (GO:0018342)	2.53860825
70	prenylation (GO:0097354)	2.53860825
71	axoneme assembly (GO:0035082)	2.53097664
72	kynurenine metabolic process (GO:0070189)	2.52392038
73	regulation of action potential (GO:0098900)	2.51790208
74	dorsal/ventral axis specification (GO:0009950)	2.51436521
75	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.51136502
76	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.51136502
77	isotype switching (GO:0045190)	2.51136502
78	epithelial cilium movement (GO:0003351)	2.49813870
79	DNA deamination (GO:0045006)	2.48102906
80	embryonic epithelial tube formation (GO:0001838)	2.47709387
81	tryptophan catabolic process (GO:0006569)	2.47486031
82	indole-containing compound catabolic process (GO:0042436)	2.47486031
83	indolalkylamine catabolic process (GO:0046218)	2.47486031
84	magnesium ion transport (GO:0015693)	2.45606238
85	ketone body metabolic process (GO:1902224)	2.44298289
86	nucleobase catabolic process (GO:0046113)	2.41227227
87	L-methionine salvage (GO:0071267)	2.40843089
88	L-methionine biosynthetic process (GO:0071265)	2.40843089
89	amino acid salvage (GO:0043102)	2.40843089
90	meiotic chromosome segregation (GO:0045132)	2.40596635
91	cilium organization (GO:0044782)	2.40115185
92	reflex (GO:0060004)	2.39328834
93	cullin deneddylation (GO:0010388)	2.37355621
94	sister chromatid cohesion (GO:0007062)	2.35702637
95	gene silencing by RNA (GO:0031047)	2.35382006
96	regulation of mitotic spindle checkpoint (GO:1903504)	2.34397012
97	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.34397012
98	protein targeting to Golgi (GO:0000042)	2.34292449
99	tryptophan metabolic process (GO:0006568)	2.33905082
100	cilium assembly (GO:0042384)	2.33610751

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.96769721
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.65153041
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.13047945
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.90166915
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.90155381
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.84778021
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.74914591
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.65844381
9	FUS_26573619_Chip-Seq_HEK293_Human	2.57320153
10	VDR_22108803_ChIP-Seq_LS180_Human	2.53720838
11	* EWS_26573619_Chip-Seq_HEK293_Human	2.34591331
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.31093994
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.23989824
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.23294570
15	P300_19829295_ChIP-Seq_ESCs_Human	2.16917012
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.16616064
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.13766715
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.08513730
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.03934970
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.90098085
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.90010832
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89075893
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.88975786
24	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.82806752
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.79497869
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.76185855
27	* MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.75499383
28	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.73525367
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71606855
30	STAT3_23295773_ChIP-Seq_U87_Human	1.70622338
31	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.66424403
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.63896353
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.62687134
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.60213980
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.60014212
36	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.56849719
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56009911
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.55594752
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55594752
40	* GABP_17652178_ChIP-ChIP_JURKAT_Human	1.49232544
41	TCF4_23295773_ChIP-Seq_U87_Human	1.48432336
42	AR_25329375_ChIP-Seq_VCAP_Human	1.47719609
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47695170
44	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.45936521
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.45777102
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.45211615
47	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44353404
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44123070
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43809237
50	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.43225550
51	MYC_18940864_ChIP-ChIP_HL60_Human	1.42889818
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40451085
53	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.39329626
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38552468
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.36868038
56	VDR_23849224_ChIP-Seq_CD4+_Human	1.34917058
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32790305
58	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32790305
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28862738
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.28620601
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27128896
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25975830
63	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.25279037
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25114517
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25088745
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.23405710
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23149666
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20020681
69	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.19955114
70	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.19561158
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19310397
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19310397
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19170355
74	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16468375
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14854623
76	AR_21572438_ChIP-Seq_LNCaP_Human	1.14557300
77	EZH2_22144423_ChIP-Seq_EOC_Human	1.13781094
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13758430
79	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.12701081
80	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.11420538
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10776100
82	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.10663918
83	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10592363
84	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09977041
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06755937
86	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.06421308
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04411650
88	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.01763238
89	CDX2_22108803_ChIP-Seq_LS180_Human	1.00715610
90	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98878031
91	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98625942
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98568771
93	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98486776
94	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.97112856
95	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96987814
96	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.96965680
97	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.95407220
98	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.95005072
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.93977193
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.93977193

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.81321249
2	MP0002102_abnormal_ear_morphology	2.99254675
3	MP0008058_abnormal_DNA_repair	2.64134787
4	MP0003787_abnormal_imprinting	2.58407932
5	MP0006292_abnormal_olfactory_placode	2.47702752
6	MP0005645_abnormal_hypothalamus_physiol	2.44754100
7	MP0008057_abnormal_DNA_replication	2.44729505
8	MP0003646_muscle_fatigue	2.16131821
9	MP0003890_abnormal_embryonic-extraembry	2.04541023
10	MP0005551_abnormal_eye_electrophysiolog	2.00257176
11	MP0003195_calcinosis	1.95106830
12	MP0009046_muscle_twitch	1.94835340
13	MP0003718_maternal_effect	1.90030472
14	MP0004147_increased_porphyrin_level	1.86555960
15	MP0000569_abnormal_digit_pigmentation	1.82639495
16	MP0001984_abnormal_olfaction	1.81124886
17	MP0002837_dystrophic_cardiac_calcinosis	1.79876851
18	MP0010094_abnormal_chromosome_stability	1.79396513
19	MP0001529_abnormal_vocalization	1.73699697
20	MP0005253_abnormal_eye_physiology	1.73454944
21	MP0002234_abnormal_pharynx_morphology	1.72911121
22	MP0000427_abnormal_hair_cycle	1.70578749
23	MP0002938_white_spotting	1.69548666
24	MP0004043_abnormal_pH_regulation	1.68440506
25	MP0006072_abnormal_retinal_apoptosis	1.67928758
26	MP0002638_abnormal_pupillary_reflex	1.67860597
27	MP0001968_abnormal_touch/_nociception	1.67144018
28	MP0003121_genomic_imprinting	1.64025742
29	MP0002736_abnormal_nociception_after	1.49498228
30	MP0009697_abnormal_copulation	1.43463625
31	MP0005187_abnormal_penis_morphology	1.39031313
32	MP0008995_early_reproductive_senescence	1.38240840
33	MP0002160_abnormal_reproductive_system	1.37804089
34	MP0000631_abnormal_neuroendocrine_gland	1.37495242
35	MP0001486_abnormal_startle_reflex	1.35721457
36	MP0003937_abnormal_limbs/digits/tail_de	1.34240848
37	MP0003786_premature_aging	1.33915032
38	MP0009745_abnormal_behavioral_response	1.32864223
39	MP0008789_abnormal_olfactory_epithelium	1.32854182
40	MP0004924_abnormal_behavior	1.32133028
41	MP0005386_behavior/neurological_phenoty	1.32133028
42	MP0000372_irregular_coat_pigmentation	1.31085117
43	MP0002735_abnormal_chemical_nociception	1.30133211
44	MP0002254_reproductive_system_inflammat	1.29145405
45	MP0004215_abnormal_myocardial_fiber	1.28569404
46	MP0000383_abnormal_hair_follicle	1.27018257
47	MP0008872_abnormal_physiological_respon	1.26618093
48	MP0001501_abnormal_sleep_pattern	1.23844853
49	MP0000647_abnormal_sebaceous_gland	1.22327128
50	MP0005379_endocrine/exocrine_gland_phen	1.17326591
51	MP0005499_abnormal_olfactory_system	1.17198211
52	MP0005394_taste/olfaction_phenotype	1.17198211
53	MP0002272_abnormal_nervous_system	1.16979140
54	MP0002163_abnormal_gland_morphology	1.16446487
55	MP0006276_abnormal_autonomic_nervous	1.16165479
56	MP0004133_heterotaxia	1.15676849
57	MP0002557_abnormal_social/conspecific_i	1.10901517
58	MP0002751_abnormal_autonomic_nervous	1.09960324
59	MP0003880_abnormal_central_pattern	1.09768678
60	MP0005389_reproductive_system_phenotype	1.07065791
61	MP0004142_abnormal_muscle_tone	1.05758701
62	MP0001929_abnormal_gametogenesis	1.05420681
63	MP0000778_abnormal_nervous_system	1.05097000
64	MP0002876_abnormal_thyroid_physiology	1.00325076
65	MP0010678_abnormal_skin_adnexa	1.00317406
66	MP0005167_abnormal_blood-brain_barrier	0.98949760
67	MP0003693_abnormal_embryo_hatching	0.98748836
68	MP0003119_abnormal_digestive_system	0.98599936
69	MP0003698_abnormal_male_reproductive	0.98350463
70	MP0002928_abnormal_bile_duct	0.95841311
71	MP0005410_abnormal_fertilization	0.93867466
72	MP0005391_vision/eye_phenotype	0.93624330
73	MP0008007_abnormal_cellular_replicative	0.93556477
74	MP0005084_abnormal_gallbladder_morpholo	0.92412446
75	MP0002210_abnormal_sex_determination	0.90926931
76	MP0001986_abnormal_taste_sensitivity	0.90800831
77	MP0002067_abnormal_sensory_capabilities	0.90107008
78	MP0008961_abnormal_basal_metabolism	0.89975693
79	MP0001293_anophthalmia	0.89875773
80	MP0000653_abnormal_sex_gland	0.89334375
81	MP0005646_abnormal_pituitary_gland	0.86687972
82	MP0000516_abnormal_urinary_system	0.86615538
83	MP0005367_renal/urinary_system_phenotyp	0.86615538
84	MP0004145_abnormal_muscle_electrophysio	0.86242228
85	MP0005195_abnormal_posterior_eye	0.85218226
86	MP0002233_abnormal_nose_morphology	0.84767961
87	MP0004484_altered_response_of	0.84103001
88	MP0001485_abnormal_pinna_reflex	0.83256646
89	MP0002184_abnormal_innervation	0.83083213
90	MP0008875_abnormal_xenobiotic_pharmacok	0.83036878
91	MP0001919_abnormal_reproductive_system	0.82659226
92	MP0006035_abnormal_mitochondrial_morpho	0.80411921
93	MP0001286_abnormal_eye_development	0.79893430
94	MP0001145_abnormal_male_reproductive	0.79356874
95	MP0002572_abnormal_emotion/affect_behav	0.79103083
96	MP0003755_abnormal_palate_morphology	0.78549324
97	MP0003122_maternal_imprinting	0.76959863
98	MP0002064_seizures	0.74995465
99	MP0002733_abnormal_thermal_nociception	0.74481788
100	MP0008775_abnormal_heart_ventricle	0.73772979

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	3.89097530
2	Pancreatic cysts (HP:0001737)	3.72982122
3	Pancreatic fibrosis (HP:0100732)	3.39503910
4	Birth length less than 3rd percentile (HP:0003561)	3.37325135
5	Abnormality of the labia minora (HP:0012880)	3.26563217
6	True hermaphroditism (HP:0010459)	3.22899785
7	Nephronophthisis (HP:0000090)	3.09787283
8	Abnormality of the renal cortex (HP:0011035)	3.07914169
9	Molar tooth sign on MRI (HP:0002419)	3.06511832
10	Abnormality of midbrain morphology (HP:0002418)	3.06511832
11	Lissencephaly (HP:0001339)	2.82491133
12	Protruding tongue (HP:0010808)	2.80749339
13	Abnormality of the renal medulla (HP:0100957)	2.80659860
14	Medial flaring of the eyebrow (HP:0010747)	2.77646991
15	Colon cancer (HP:0003003)	2.73047374
16	Progressive inability to walk (HP:0002505)	2.66568587
17	Intestinal atresia (HP:0011100)	2.62446502
18	Broad-based gait (HP:0002136)	2.61350457
19	Congenital stationary night blindness (HP:0007642)	2.59159207
20	Renal cortical cysts (HP:0000803)	2.57074938
21	Type II lissencephaly (HP:0007260)	2.51054447
22	Neoplasm of the adrenal cortex (HP:0100641)	2.45581985
23	Chronic hepatic failure (HP:0100626)	2.43708360
24	Inability to walk (HP:0002540)	2.42453299
25	Volvulus (HP:0002580)	2.34504179
26	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.34220546
27	Abnormal biliary tract physiology (HP:0012439)	2.31362698
28	Bile duct proliferation (HP:0001408)	2.31362698
29	Gaze-evoked nystagmus (HP:0000640)	2.30604185
30	Cystic liver disease (HP:0006706)	2.29718407
31	Pendular nystagmus (HP:0012043)	2.28408501
32	Abnormality of chromosome stability (HP:0003220)	2.27986040
33	Congenital primary aphakia (HP:0007707)	2.27942187
34	Drooling (HP:0002307)	2.27636401
35	Gait imbalance (HP:0002141)	2.26422374
36	Hypothermia (HP:0002045)	2.25621989
37	Attenuation of retinal blood vessels (HP:0007843)	2.25535621
38	Widely spaced teeth (HP:0000687)	2.19956905
39	Tubular atrophy (HP:0000092)	2.19730375
40	Patellar aplasia (HP:0006443)	2.18816001
41	Methylmalonic acidemia (HP:0002912)	2.15065242
42	Fair hair (HP:0002286)	2.13925466
43	Nephrogenic diabetes insipidus (HP:0009806)	2.13922305
44	Cerebellar dysplasia (HP:0007033)	2.12331871
45	Abnormality of the ileum (HP:0001549)	2.11910064
46	Oligodactyly (hands) (HP:0001180)	2.11076662
47	Absent speech (HP:0001344)	2.10665525
48	Optic nerve hypoplasia (HP:0000609)	2.07512736
49	Meckel diverticulum (HP:0002245)	2.07199107
50	Aplasia/Hypoplasia of the patella (HP:0006498)	2.04462805
51	Abnormality of the pons (HP:0007361)	2.04057064
52	Sloping forehead (HP:0000340)	2.03978974
53	Abnormal drinking behavior (HP:0030082)	2.03929153
54	Polydipsia (HP:0001959)	2.03929153
55	Glioma (HP:0009733)	2.03772847
56	Poor coordination (HP:0002370)	2.02447603
57	Excessive salivation (HP:0003781)	2.02387543
58	Genital tract atresia (HP:0001827)	2.02372175
59	Febrile seizures (HP:0002373)	2.01220260
60	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.00058920
61	Hypoplastic labia majora (HP:0000059)	1.99127998
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.98913271
63	Small hand (HP:0200055)	1.98674900
64	Anencephaly (HP:0002323)	1.96427657
65	Pachygyria (HP:0001302)	1.95722509
66	Vaginal atresia (HP:0000148)	1.95538681
67	Hemiparesis (HP:0001269)	1.94205384
68	Labial hypoplasia (HP:0000066)	1.93435774
69	Gastrointestinal atresia (HP:0002589)	1.92100617
70	Stomach cancer (HP:0012126)	1.91453964
71	Large for gestational age (HP:0001520)	1.90694821
72	Chorioretinal atrophy (HP:0000533)	1.89897040
73	Hyperglycinemia (HP:0002154)	1.85055994
74	Chromsome breakage (HP:0040012)	1.84696111
75	Dandy-Walker malformation (HP:0001305)	1.82798233
76	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.82244521
77	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.80362052
78	Astrocytoma (HP:0009592)	1.79959083
79	Abnormality of the astrocytes (HP:0100707)	1.79959083
80	Abnormality of the labia majora (HP:0012881)	1.79726687
81	Sclerocornea (HP:0000647)	1.79164977
82	Congenital hepatic fibrosis (HP:0002612)	1.79023661
83	Hypoplastic female external genitalia (HP:0012815)	1.78796348
84	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.76385868
85	Furrowed tongue (HP:0000221)	1.75743943
86	Astigmatism (HP:0000483)	1.74510334
87	Abolished electroretinogram (ERG) (HP:0000550)	1.74479813
88	Hypoplasia of the pons (HP:0012110)	1.74153623
89	Narrow forehead (HP:0000341)	1.73492114
90	Methylmalonic aciduria (HP:0012120)	1.73416739
91	Abnormality of the preputium (HP:0100587)	1.72544311
92	Abnormality of the renal collecting system (HP:0004742)	1.70881241
93	Duplicated collecting system (HP:0000081)	1.70757707
94	Preaxial hand polydactyly (HP:0001177)	1.70179925
95	Postaxial foot polydactyly (HP:0001830)	1.67033953
96	Clubbing of toes (HP:0100760)	1.65426860
97	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.65193158
98	Abnormality of alanine metabolism (HP:0010916)	1.65193158
99	Hyperalaninemia (HP:0003348)	1.65193158
100	Aqueductal stenosis (HP:0002410)	1.62753670

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.93897924
2	WNK3	3.40511221
3	ACVR1B	3.05076497
4	BMPR1B	2.99724422
5	CASK	2.98346335
6	ZAK	2.70335641
7	MAP4K2	2.60847807
8	MAP3K4	2.30414489
9	MKNK2	2.20573550
10	NUAK1	2.19748174
11	EIF2AK3	2.14040254
12	TRIM28	1.91712989
13	GRK1	1.90300434
14	BRSK2	1.86770891
15	ADRBK2	1.81267021
16	MAPK13	1.77617255
17	TSSK6	1.66618279
18	BCKDK	1.63791609
19	MAP2K7	1.53145799
20	AKT3	1.48802338
21	CSNK1G1	1.48004627
22	BUB1	1.43973943
23	BCR	1.43127402
24	PINK1	1.40921252
25	TNIK	1.40703467
26	PLK4	1.38588471
27	STK38L	1.37723945
28	MKNK1	1.37149923
29	WEE1	1.30593766
30	MARK1	1.28762216
31	CSNK1A1L	1.26786897
32	CSNK1G2	1.26255411
33	TLK1	1.22101684
34	CSNK1G3	1.18965803
35	PNCK	1.18131214
36	ERBB3	1.17717565
37	TAOK3	1.16960231
38	PLK2	1.13947898
39	SRPK1	1.13748253
40	TGFBR1	1.12289342
41	PLK3	1.11526155
42	VRK1	1.10993405
43	WNK4	1.10729079
44	BRD4	1.03469192
45	CAMKK2	0.98847887
46	INSRR	0.97254923
47	OXSR1	0.95503219
48	NLK	0.95286950
49	PAK3	0.93672670
50	STK39	0.93498773
51	FGFR2	0.91035667
52	CDK3	0.84642926
53	MST4	0.82652649
54	PRKCE	0.81534645
55	CAMK1G	0.81530846
56	CAMK1D	0.73541274
57	LATS1	0.72808992
58	PLK1	0.71236352
59	TTK	0.70408107
60	CDC7	0.69985144
61	SGK2	0.68399474
62	DAPK2	0.64991842
63	ATR	0.64932830
64	TIE1	0.62420502
65	ATM	0.61059400
66	TAF1	0.61036552
67	OBSCN	0.59200592
68	EPHA4	0.57419443
69	PRKCG	0.55738147
70	PTK2B	0.53687949
71	DYRK2	0.52239106
72	STK3	0.50661316
73	EIF2AK2	0.49128218
74	RPS6KA5	0.48152738
75	FER	0.47311710
76	ADRBK1	0.47207346
77	FLT3	0.46906191
78	NEK1	0.46155909
79	CSNK1D	0.44892119
80	PKN1	0.43069715
81	CHEK2	0.42606025
82	PRKAA1	0.41137383
83	CAMK4	0.39194048
84	SGK223	0.39186699
85	SGK494	0.39186699
86	DYRK3	0.35419784
87	NEK2	0.35284277
88	NEK9	0.35146010
89	CSNK1A1	0.34554390
90	PRKAA2	0.34056516
91	TEC	0.33195740
92	CAMK2A	0.32475165
93	IRAK1	0.32018071
94	DYRK1A	0.30743668
95	CHUK	0.30668480
96	PHKG1	0.30515403
97	PHKG2	0.30515403
98	CSNK1E	0.28215928
99	CHEK1	0.27395452
100	PRKDC	0.27238649

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fanconi anemia pathway_Homo sapiens_hsa03460	2.82938627
2	Basal transcription factors_Homo sapiens_hsa03022	2.66091941
3	Phototransduction_Homo sapiens_hsa04744	2.53966805
4	Selenocompound metabolism_Homo sapiens_hsa00450	2.52634756
5	Propanoate metabolism_Homo sapiens_hsa00640	2.44046548
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.43955108
7	Homologous recombination_Homo sapiens_hsa03440	2.39884005
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.36765352
9	Non-homologous end-joining_Homo sapiens_hsa03450	2.29644216
10	Butanoate metabolism_Homo sapiens_hsa00650	2.16187071
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.14304555
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.10845100
13	Nitrogen metabolism_Homo sapiens_hsa00910	2.09011242
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.06201715
15	Protein export_Homo sapiens_hsa03060	2.06096818
16	RNA degradation_Homo sapiens_hsa03018	2.05877571
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.93012992
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.81471662
19	RNA polymerase_Homo sapiens_hsa03020	1.74034024
20	Nicotine addiction_Homo sapiens_hsa05033	1.67453173
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.65482995
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.64890786
23	One carbon pool by folate_Homo sapiens_hsa00670	1.59523165
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.57591053
25	Mismatch repair_Homo sapiens_hsa03430	1.56908175
26	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.53048089
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.49747625
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.48381501
29	RNA transport_Homo sapiens_hsa03013	1.46268282
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.45359550
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.43274889
32	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.40185221
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.36840012
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.29463148
35	Taste transduction_Homo sapiens_hsa04742	1.18149057
36	Circadian rhythm_Homo sapiens_hsa04710	1.15153249
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.14291375
38	Peroxisome_Homo sapiens_hsa04146	1.07841202
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06631136
40	ABC transporters_Homo sapiens_hsa02010	1.03348767
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.02119983
42	Cell cycle_Homo sapiens_hsa04110	0.99923429
43	Sulfur metabolism_Homo sapiens_hsa00920	0.99414040
44	Steroid biosynthesis_Homo sapiens_hsa00100	0.98214871
45	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.97321420
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.93257340
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.92657640
48	Olfactory transduction_Homo sapiens_hsa04740	0.90751170
49	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.88949375
50	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.87187650
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.86795269
52	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.79654259
53	Circadian entrainment_Homo sapiens_hsa04713	0.79454846
54	Regulation of autophagy_Homo sapiens_hsa04140	0.79279641
55	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.77196691
56	Oocyte meiosis_Homo sapiens_hsa04114	0.75850432
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.75304224
58	GABAergic synapse_Homo sapiens_hsa04727	0.74956762
59	Purine metabolism_Homo sapiens_hsa00230	0.74782049
60	Base excision repair_Homo sapiens_hsa03410	0.73041970
61	Serotonergic synapse_Homo sapiens_hsa04726	0.72598785
62	p53 signaling pathway_Homo sapiens_hsa04115	0.72228521
63	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.71635252
64	Alcoholism_Homo sapiens_hsa05034	0.71473844
65	Insulin secretion_Homo sapiens_hsa04911	0.70472542
66	Glutamatergic synapse_Homo sapiens_hsa04724	0.68654212
67	Lysine degradation_Homo sapiens_hsa00310	0.68621380
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.67898187
69	Morphine addiction_Homo sapiens_hsa05032	0.66818650
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66268762
71	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.64063625
72	Caffeine metabolism_Homo sapiens_hsa00232	0.62050864
73	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.60417504
74	Sulfur relay system_Homo sapiens_hsa04122	0.59951414
75	mRNA surveillance pathway_Homo sapiens_hsa03015	0.59906537
76	Long-term depression_Homo sapiens_hsa04730	0.55553483
77	Oxidative phosphorylation_Homo sapiens_hsa00190	0.55534489
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54935910
79	DNA replication_Homo sapiens_hsa03030	0.54888243
80	Metabolic pathways_Homo sapiens_hsa01100	0.53641974
81	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.51857265
82	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.51729869
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50226322
84	Fatty acid elongation_Homo sapiens_hsa00062	0.48359080
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.46874762
86	Retinol metabolism_Homo sapiens_hsa00830	0.45923734
87	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43622444
88	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.43597847
89	Proteasome_Homo sapiens_hsa03050	0.43096536
90	Pyrimidine metabolism_Homo sapiens_hsa00240	0.42726219
91	Hippo signaling pathway_Homo sapiens_hsa04390	0.42581478
92	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.41902854
93	Calcium signaling pathway_Homo sapiens_hsa04020	0.40668313
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.40534720
95	Salivary secretion_Homo sapiens_hsa04970	0.39544930
96	Basal cell carcinoma_Homo sapiens_hsa05217	0.39338773
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38582998
98	Spliceosome_Homo sapiens_hsa03040	0.36986855
99	Arginine biosynthesis_Homo sapiens_hsa00220	0.34859286
100	Huntingtons disease_Homo sapiens_hsa05016	0.34556767

ZNF543

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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