ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.85228525
2	response to pheromone (GO:0019236)	4.12215052
3	indole-containing compound catabolic process (GO:0042436)	4.10360322
4	indolalkylamine catabolic process (GO:0046218)	4.10360322
5	tryptophan catabolic process (GO:0006569)	4.10360322
6	L-fucose catabolic process (GO:0042355)	3.85325676
7	fucose catabolic process (GO:0019317)	3.85325676
8	L-fucose metabolic process (GO:0042354)	3.85325676
9	sulfation (GO:0051923)	3.83302613
10	indolalkylamine metabolic process (GO:0006586)	3.81434392
11	kynurenine metabolic process (GO:0070189)	3.79215622
12	gamma-aminobutyric acid transport (GO:0015812)	3.74157318
13	protein K11-linked deubiquitination (GO:0035871)	3.72682975
14	tryptophan metabolic process (GO:0006568)	3.54818791
15	meiotic chromosome segregation (GO:0045132)	3.53707673
16	somite development (GO:0061053)	3.47100682
17	protein polyglutamylation (GO:0018095)	3.44093893
18	reciprocal DNA recombination (GO:0035825)	3.33830113
19	reciprocal meiotic recombination (GO:0007131)	3.33830113
20	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.32357805
21	detection of light stimulus involved in visual perception (GO:0050908)	3.30551660
22	detection of light stimulus involved in sensory perception (GO:0050962)	3.30551660
23	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.30101225
24	spinal cord motor neuron differentiation (GO:0021522)	3.19359194
25	pyrimidine nucleobase catabolic process (GO:0006208)	3.15863379
26	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.07315489
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.07193899
28	rRNA catabolic process (GO:0016075)	3.04796621
29	axoneme assembly (GO:0035082)	3.03312675
30	cellular ketone body metabolic process (GO:0046950)	3.02707047
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.95380879
32	NADH dehydrogenase complex assembly (GO:0010257)	2.95380879
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.95380879
34	postsynaptic membrane organization (GO:0001941)	2.94442858
35	indole-containing compound metabolic process (GO:0042430)	2.94291519
36	neuronal action potential (GO:0019228)	2.94204897
37	cAMP catabolic process (GO:0006198)	2.92085625
38	protein complex biogenesis (GO:0070271)	2.91684445
39	behavioral response to ethanol (GO:0048149)	2.89187922
40	epithelial cilium movement (GO:0003351)	2.86069739
41	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.86019464
42	negative regulation of mast cell activation (GO:0033004)	2.85221004
43	negative regulation of systemic arterial blood pressure (GO:0003085)	2.85112320
44	protein-cofactor linkage (GO:0018065)	2.83699920
45	ketone body metabolic process (GO:1902224)	2.83266471
46	nonmotile primary cilium assembly (GO:0035058)	2.82167886
47	cellular biogenic amine catabolic process (GO:0042402)	2.80103409
48	amine catabolic process (GO:0009310)	2.80103409
49	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.79277218
50	photoreceptor cell maintenance (GO:0045494)	2.79060602
51	piRNA metabolic process (GO:0034587)	2.77614898
52	regulation of action potential (GO:0098900)	2.76939869
53	neural tube formation (GO:0001841)	2.76701215
54	mitochondrial respiratory chain complex assembly (GO:0033108)	2.75724644
55	auditory receptor cell stereocilium organization (GO:0060088)	2.75309027
56	inner ear receptor stereocilium organization (GO:0060122)	2.72022308
57	tachykinin receptor signaling pathway (GO:0007217)	2.71054746
58	nucleobase catabolic process (GO:0046113)	2.65665299
59	cell proliferation in forebrain (GO:0021846)	2.65318110
60	reflex (GO:0060004)	2.65174847
61	primary amino compound metabolic process (GO:1901160)	2.65116014
62	startle response (GO:0001964)	2.63676564
63	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.63476025
64	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.63476025
65	cellular response to ATP (GO:0071318)	2.62998147
66	head development (GO:0060322)	2.62964879
67	cyclic nucleotide catabolic process (GO:0009214)	2.61404352
68	cilium organization (GO:0044782)	2.60819302
69	protein localization to cilium (GO:0061512)	2.60475118
70	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.60424415
71	cilium morphogenesis (GO:0060271)	2.59726698
72	cilium or flagellum-dependent cell motility (GO:0001539)	2.59712251
73	regulation of cilium movement (GO:0003352)	2.59286817
74	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.56922002
75	cilium assembly (GO:0042384)	2.56522049
76	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.55871256
77	synaptic transmission, cholinergic (GO:0007271)	2.55573149
78	cell differentiation in spinal cord (GO:0021515)	2.54066632
79	DNA deamination (GO:0045006)	2.53456895
80	transmission of nerve impulse (GO:0019226)	2.52275096
81	cilium movement (GO:0003341)	2.52215799
82	preassembly of GPI anchor in ER membrane (GO:0016254)	2.51117838
83	interkinetic nuclear migration (GO:0022027)	2.50609276
84	photoreceptor cell development (GO:0042461)	2.50031571
85	positive regulation of fatty acid transport (GO:2000193)	2.49754946
86	regulation of hexokinase activity (GO:1903299)	2.48775364
87	regulation of glucokinase activity (GO:0033131)	2.48775364
88	C-terminal protein amino acid modification (GO:0018410)	2.48678855
89	positive regulation of fatty acid oxidation (GO:0046321)	2.48453842
90	serotonin metabolic process (GO:0042428)	2.48397842
91	C-terminal protein lipidation (GO:0006501)	2.47148301
92	DNA methylation involved in gamete generation (GO:0043046)	2.45300052
93	membrane depolarization during action potential (GO:0086010)	2.44633067
94	presynaptic membrane assembly (GO:0097105)	2.41177039
95	kidney morphogenesis (GO:0060993)	2.40836905
96	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.39773372
97	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.39293782
98	oxidative demethylation (GO:0070989)	2.38496867
99	male meiosis I (GO:0007141)	2.38403946
100	regulation of hippo signaling (GO:0035330)	2.38157030

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.73665975
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.49467177
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.09071360
4	VDR_22108803_ChIP-Seq_LS180_Human	2.91457197
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.72232258
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.67732125
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.37044777
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.36255599
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.36031561
10	EWS_26573619_Chip-Seq_HEK293_Human	2.34494583
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.33718222
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.29082265
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23718042
14	FUS_26573619_Chip-Seq_HEK293_Human	2.21331927
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05779298
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.96395401
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.92430619
18	P300_19829295_ChIP-Seq_ESCs_Human	1.90615208
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88901143
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.88752598
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84935760
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.82868548
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.68660747
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.65530556
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64245212
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.62797968
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.60039315
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.57916657
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57471243
30	STAT3_23295773_ChIP-Seq_U87_Human	1.56082313
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.55296937
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55252753
33	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.55252753
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55087775
35	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.53887961
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53834562
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.53611153
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53611153
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.53029659
40	REST_21632747_ChIP-Seq_MESCs_Mouse	1.51559332
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49389873
42	TCF4_23295773_ChIP-Seq_U87_Human	1.48506578
43	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.48438189
44	AR_21572438_ChIP-Seq_LNCaP_Human	1.46121834
45	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43042220
46	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42483710
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.41885744
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.40920954
49	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.39526515
50	RNF2_27304074_Chip-Seq_NSC_Mouse	1.38765564
51	AR_25329375_ChIP-Seq_VCAP_Human	1.38422466
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.35426118
53	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.34282704
54	MYC_18940864_ChIP-ChIP_HL60_Human	1.33060637
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32926391
56	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29706080
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28963573
58	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26086739
59	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.25325520
60	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.24856049
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23528452
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23294338
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21840498
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20702021
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20702021
66	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.19976390
67	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19044645
68	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.18524876
69	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.18054075
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17301798
71	DROSHA_22980978_ChIP-Seq_HELA_Human	1.13347176
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13249588
73	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13007752
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.11313461
75	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11272049
76	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11272049
77	* ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06974494
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06480264
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06154872
80	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05854829
81	NCOR_22424771_ChIP-Seq_293T_Human	1.05261131
82	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04583476
83	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04041440
84	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.03071390
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02973154
86	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.02939959
87	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.02934758
88	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.02552203
89	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02372744
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02143660
91	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.00563459
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00447339
93	* HOXB7_26014856_ChIP-Seq_BT474_Human	1.00156615
94	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.99989082
95	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.98751976
96	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.98662543
97	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.98567162
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98483306
99	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.98114768
100	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97817082

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.05959829
2	MP0003646_muscle_fatigue	2.73709609
3	MP0003195_calcinosis	2.66762814
4	MP0003880_abnormal_central_pattern	2.56827776
5	MP0001968_abnormal_touch/_nociception	2.41338773
6	MP0002102_abnormal_ear_morphology	2.33258171
7	MP0005551_abnormal_eye_electrophysiolog	2.23288329
8	MP0005646_abnormal_pituitary_gland	2.20865766
9	MP0006292_abnormal_olfactory_placode	2.13539070
10	MP0003136_yellow_coat_color	2.03988944
11	MP0008877_abnormal_DNA_methylation	2.02308885
12	MP0001986_abnormal_taste_sensitivity	1.99994466
13	MP0009745_abnormal_behavioral_response	1.99450397
14	MP0004885_abnormal_endolymph	1.92795037
15	MP0009046_muscle_twitch	1.92628855
16	MP0002272_abnormal_nervous_system	1.89511119
17	MP0002638_abnormal_pupillary_reflex	1.85911675
18	MP0005645_abnormal_hypothalamus_physiol	1.83035143
19	MP0008872_abnormal_physiological_respon	1.77651611
20	MP0006276_abnormal_autonomic_nervous	1.72199051
21	MP0006072_abnormal_retinal_apoptosis	1.70374950
22	MP0004142_abnormal_muscle_tone	1.67443056
23	MP0002736_abnormal_nociception_after	1.65956902
24	MP0004742_abnormal_vestibular_system	1.65729134
25	MP0005253_abnormal_eye_physiology	1.65365435
26	MP0002837_dystrophic_cardiac_calcinosis	1.64847249
27	MP0002928_abnormal_bile_duct	1.64604095
28	MP0002876_abnormal_thyroid_physiology	1.63411331
29	MP0000631_abnormal_neuroendocrine_gland	1.61348027
30	MP0001485_abnormal_pinna_reflex	1.61172826
31	MP0004133_heterotaxia	1.59913205
32	MP0004145_abnormal_muscle_electrophysio	1.59700289
33	MP0002735_abnormal_chemical_nociception	1.57231962
34	MP0003787_abnormal_imprinting	1.51698178
35	MP0005423_abnormal_somatic_nervous	1.51098022
36	MP0001501_abnormal_sleep_pattern	1.48497448
37	MP0002064_seizures	1.48472906
38	MP0001486_abnormal_startle_reflex	1.45683702
39	MP0000372_irregular_coat_pigmentation	1.45122508
40	MP0005085_abnormal_gallbladder_physiolo	1.40363328
41	MP0008875_abnormal_xenobiotic_pharmacok	1.37722471
42	MP0002557_abnormal_social/conspecific_i	1.36907614
43	MP0002733_abnormal_thermal_nociception	1.36568173
44	MP0002572_abnormal_emotion/affect_behav	1.34725516
45	MP0003635_abnormal_synaptic_transmissio	1.33492098
46	MP0000427_abnormal_hair_cycle	1.32811091
47	MP0001970_abnormal_pain_threshold	1.32740257
48	MP0010386_abnormal_urinary_bladder	1.30444092
49	MP0002063_abnormal_learning/memory/cond	1.28948370
50	MP0005084_abnormal_gallbladder_morpholo	1.27687775
51	MP0005174_abnormal_tail_pigmentation	1.23743944
52	MP0002160_abnormal_reproductive_system	1.20129068
53	MP0004043_abnormal_pH_regulation	1.19743134
54	MP0004130_abnormal_muscle_cell	1.16467503
55	MP0002067_abnormal_sensory_capabilities	1.15938532
56	MP0002938_white_spotting	1.15846518
57	MP0001984_abnormal_olfaction	1.15803039
58	MP0003011_delayed_dark_adaptation	1.14737506
59	MP0004215_abnormal_myocardial_fiber	1.13715272
60	MP0000778_abnormal_nervous_system	1.13430783
61	MP0000026_abnormal_inner_ear	1.11782761
62	MP0005386_behavior/neurological_phenoty	1.10753649
63	MP0004924_abnormal_behavior	1.10753649
64	MP0005167_abnormal_blood-brain_barrier	1.10406434
65	MP0004147_increased_porphyrin_level	1.09208946
66	MP0002163_abnormal_gland_morphology	1.06508503
67	MP0005410_abnormal_fertilization	1.06121566
68	MP0005195_abnormal_posterior_eye	1.05848369
69	MP0002653_abnormal_ependyma_morphology	1.05604732
70	MP0005389_reproductive_system_phenotype	1.03398744
71	MP0001529_abnormal_vocalization	1.02529867
72	MP0002734_abnormal_mechanical_nocicepti	1.02219287
73	MP0002095_abnormal_skin_pigmentation	0.99839934
74	MP0008995_early_reproductive_senescence	0.99676533
75	MP0002752_abnormal_somatic_nervous	0.99054466
76	MP0001963_abnormal_hearing_physiology	0.98787862
77	MP0005310_abnormal_salivary_gland	0.98527665
78	MP0008789_abnormal_olfactory_epithelium	0.97867159
79	MP0001324_abnormal_eye_pigmentation	0.96721961
80	MP0003252_abnormal_bile_duct	0.92471752
81	MP0005171_absent_coat_pigmentation	0.91547262
82	MP0008775_abnormal_heart_ventricle	0.90839495
83	MP0003119_abnormal_digestive_system	0.90426116
84	MP0002234_abnormal_pharynx_morphology	0.89544671
85	MP0002751_abnormal_autonomic_nervous	0.89288832
86	MP0000049_abnormal_middle_ear	0.89031553
87	MP0002138_abnormal_hepatobiliary_system	0.87418294
88	MP0003698_abnormal_male_reproductive	0.87132404
89	MP0002184_abnormal_innervation	0.86675241
90	MP0009764_decreased_sensitivity_to	0.85763948
91	MP0003283_abnormal_digestive_organ	0.85371502
92	MP0001502_abnormal_circadian_rhythm	0.83633046
93	MP0005377_hearing/vestibular/ear_phenot	0.82916680
94	MP0003878_abnormal_ear_physiology	0.82916680
95	MP0003890_abnormal_embryonic-extraembry	0.82591987
96	MP0001905_abnormal_dopamine_level	0.81819233
97	MP0002229_neurodegeneration	0.81769290
98	MP0000383_abnormal_hair_follicle	0.81608830
99	MP0004484_altered_response_of	0.80710004
100	MP0003937_abnormal_limbs/digits/tail_de	0.79638601

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.60404269
2	True hermaphroditism (HP:0010459)	4.37588931
3	Pancreatic fibrosis (HP:0100732)	4.30757351
4	Molar tooth sign on MRI (HP:0002419)	4.17166031
5	Abnormality of midbrain morphology (HP:0002418)	4.17166031
6	Congenital stationary night blindness (HP:0007642)	3.85268500
7	Nephronophthisis (HP:0000090)	3.79371022
8	Abnormality of the renal medulla (HP:0100957)	3.25098927
9	Attenuation of retinal blood vessels (HP:0007843)	3.17139708
10	Type II lissencephaly (HP:0007260)	3.14429033
11	Chronic hepatic failure (HP:0100626)	3.12378348
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.00625419
13	Abnormality of the renal cortex (HP:0011035)	2.99113272
14	Cystic liver disease (HP:0006706)	2.96599466
15	Abnormal rod and cone electroretinograms (HP:0008323)	2.96223794
16	Pendular nystagmus (HP:0012043)	2.82089218
17	Decreased central vision (HP:0007663)	2.81454866
18	Medial flaring of the eyebrow (HP:0010747)	2.79625657
19	Abolished electroretinogram (ERG) (HP:0000550)	2.76194166
20	Progressive cerebellar ataxia (HP:0002073)	2.74536723
21	Hyperventilation (HP:0002883)	2.67521174
22	Decreased circulating renin level (HP:0003351)	2.65979496
23	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.65354780
24	Abnormality of alanine metabolism (HP:0010916)	2.65354780
25	Hyperalaninemia (HP:0003348)	2.65354780
26	Gaze-evoked nystagmus (HP:0000640)	2.56433100
27	Tubular atrophy (HP:0000092)	2.53334859
28	Sclerocornea (HP:0000647)	2.53082728
29	Inability to walk (HP:0002540)	2.52331089
30	Anencephaly (HP:0002323)	2.52303013
31	Genetic anticipation (HP:0003743)	2.46192837
32	Furrowed tongue (HP:0000221)	2.40973221
33	Hemiparesis (HP:0001269)	2.36888445
34	Polydipsia (HP:0001959)	2.36243697
35	Abnormal drinking behavior (HP:0030082)	2.36243697
36	Congenital hepatic fibrosis (HP:0002612)	2.36129015
37	Cerebellar dysplasia (HP:0007033)	2.35837221
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.35576313
39	Abnormal biliary tract physiology (HP:0012439)	2.35491493
40	Bile duct proliferation (HP:0001408)	2.35491493
41	Broad-based gait (HP:0002136)	2.35135802
42	Bony spicule pigmentary retinopathy (HP:0007737)	2.33702933
43	Increased corneal curvature (HP:0100692)	2.33061197
44	Keratoconus (HP:0000563)	2.33061197
45	Gait imbalance (HP:0002141)	2.28175645
46	Renal cortical cysts (HP:0000803)	2.26388696
47	Male pseudohermaphroditism (HP:0000037)	2.25319854
48	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.22309951
49	Absent/shortened dynein arms (HP:0200106)	2.22309951
50	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.21421908
51	Congenital primary aphakia (HP:0007707)	2.19991070
52	Postaxial foot polydactyly (HP:0001830)	2.18816430
53	Lissencephaly (HP:0001339)	2.18741009
54	Progressive inability to walk (HP:0002505)	2.17586267
55	Thyroid-stimulating hormone excess (HP:0002925)	2.16293513
56	Febrile seizures (HP:0002373)	2.12229811
57	Congenital sensorineural hearing impairment (HP:0008527)	2.11865332
58	Chorioretinal atrophy (HP:0000533)	2.09284552
59	Occipital encephalocele (HP:0002085)	2.07046862
60	Agitation (HP:0000713)	2.04896853
61	Focal seizures (HP:0007359)	2.04568895
62	Focal motor seizures (HP:0011153)	2.03446341
63	Lipid accumulation in hepatocytes (HP:0006561)	2.02472036
64	Protruding tongue (HP:0010808)	1.99647095
65	Fair hair (HP:0002286)	1.98508671
66	Nephrogenic diabetes insipidus (HP:0009806)	1.97098663
67	Abnormal respiratory epithelium morphology (HP:0012253)	1.97035221
68	Abnormal respiratory motile cilium morphology (HP:0005938)	1.97035221
69	Abnormal respiratory motile cilium physiology (HP:0012261)	1.95210100
70	Dialeptic seizures (HP:0011146)	1.94046194
71	Genital tract atresia (HP:0001827)	1.93597935
72	Large for gestational age (HP:0001520)	1.93350060
73	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.92644712
74	Abnormal ciliary motility (HP:0012262)	1.91371067
75	Optic nerve hypoplasia (HP:0000609)	1.91053622
76	Patellar aplasia (HP:0006443)	1.90970554
77	Polyuria (HP:0000103)	1.90529692
78	Clumsiness (HP:0002312)	1.90311081
79	Retinal dysplasia (HP:0007973)	1.89309293
80	Vaginal atresia (HP:0000148)	1.89136335
81	Absent speech (HP:0001344)	1.89125463
82	Aplasia/Hypoplasia of the patella (HP:0006498)	1.87790789
83	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.85834986
84	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.84913716
85	Drooling (HP:0002307)	1.83166630
86	Preaxial hand polydactyly (HP:0001177)	1.81982100
87	Pachygyria (HP:0001302)	1.81361214
88	Congenital, generalized hypertrichosis (HP:0004540)	1.80218289
89	Concave nail (HP:0001598)	1.79812192
90	Birth length less than 3rd percentile (HP:0003561)	1.78108065
91	Asplenia (HP:0001746)	1.78102076
92	Poor coordination (HP:0002370)	1.75500731
93	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74880104
94	Retinitis pigmentosa (HP:0000510)	1.72264068
95	Methylmalonic acidemia (HP:0002912)	1.70631154
96	Mitochondrial inheritance (HP:0001427)	1.69235923
97	Increased hepatocellular lipid droplets (HP:0006565)	1.68934696
98	Small hand (HP:0200055)	1.68115881
99	Oligohydramnios (HP:0001562)	1.68009217
100	Postaxial hand polydactyly (HP:0001162)	1.68006275

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.54508622
2	ADRBK2	3.72983215
3	BMPR1B	2.66185603
4	BLK	2.60871843
5	WNK3	2.59432013
6	GRK1	2.39977204
7	ZAK	2.36813446
8	MAP3K4	2.34513985
9	MAPK13	2.31207904
10	PINK1	2.27175757
11	CASK	2.23587392
12	TLK1	2.13305591
13	MAP4K2	2.11447019
14	WNK4	2.07656929
15	INSRR	1.87710376
16	CAMKK2	1.86736280
17	ACVR1B	1.84481143
18	MARK1	1.68733783
19	MAP2K7	1.68567248
20	NUAK1	1.47627890
21	DYRK2	1.30564923
22	DAPK2	1.29339592
23	ADRBK1	1.27758466
24	TAOK3	1.22224884
25	OXSR1	1.19476481
26	EPHA4	1.16975312
27	STK38L	1.11696764
28	CAMK1D	1.06088819
29	NTRK3	1.05620920
30	TNIK	1.03156935
31	PRKCG	1.03145882
32	VRK1	1.03020241
33	PAK3	0.99588319
34	MKNK2	0.99572430
35	PRKCE	0.99088566
36	STK39	0.98087380
37	CAMK4	0.95142136
38	PNCK	0.91995711
39	TGFBR1	0.88713651
40	MUSK	0.87333368
41	TXK	0.86458645
42	TIE1	0.83462451
43	NTRK2	0.82680428
44	OBSCN	0.82508367
45	MAPK15	0.82133457
46	DYRK3	0.79062031
47	PKN1	0.78987992
48	PTK2B	0.77078961
49	RPS6KA5	0.76595923
50	NEK2	0.73302970
51	CSNK1G2	0.71680137
52	CAMK1G	0.71293221
53	MAP2K4	0.70049984
54	PLK2	0.68884486
55	CAMK2A	0.68737049
56	STK11	0.67120920
57	CCNB1	0.66764810
58	MAPKAPK5	0.66704195
59	CAMK1	0.66179604
60	SIK2	0.64466430
61	PIK3CA	0.63218708
62	CSNK1A1L	0.61459113
63	FLT3	0.60482245
64	BRSK2	0.59185796
65	GRK5	0.58629517
66	PLK4	0.55882952
67	MAP2K6	0.55813523
68	FGFR2	0.55466876
69	CSNK1G3	0.54668289
70	PRKACA	0.54389909
71	TRIM28	0.53431135
72	MARK3	0.53292549
73	EPHA3	0.52440532
74	CSNK1G1	0.51447966
75	GRK7	0.50311134
76	PRKCZ	0.47549357
77	PRKAA1	0.46216616
78	PRKCQ	0.45693231
79	AKT3	0.44058876
80	BCKDK	0.42788631
81	MAP3K9	0.42591893
82	CSNK1A1	0.42316241
83	DYRK1A	0.41841175
84	SGK2	0.40773873
85	CAMKK1	0.40533089
86	TEC	0.40134506
87	RPS6KA6	0.39501051
88	BCR	0.39049282
89	ATR	0.38179091
90	PHKG1	0.37787607
91	PHKG2	0.37787607
92	PRKG1	0.37248170
93	TAF1	0.36569171
94	ERBB3	0.36163904
95	MAPKAPK3	0.35789097
96	SGK494	0.35620450
97	SGK223	0.35620450
98	IKBKB	0.35011965
99	PRKCA	0.32964431
100	TNK2	0.32720718

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.07907353
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.77021080
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.67009547
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.63331078
5	Phototransduction_Homo sapiens_hsa04744	2.55495010
6	Butanoate metabolism_Homo sapiens_hsa00650	2.24503915
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.21390669
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.14281451
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.10550542
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.09314391
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.02886589
12	Taste transduction_Homo sapiens_hsa04742	1.98091476
13	Morphine addiction_Homo sapiens_hsa05032	1.94778730
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.92406807
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.83453683
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.81571571
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.77496570
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.74493553
19	Homologous recombination_Homo sapiens_hsa03440	1.72100620
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.69565457
21	Caffeine metabolism_Homo sapiens_hsa00232	1.65066009
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.64680231
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.59093450
24	Regulation of autophagy_Homo sapiens_hsa04140	1.57230730
25	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.55004875
26	GABAergic synapse_Homo sapiens_hsa04727	1.49424732
27	Basal transcription factors_Homo sapiens_hsa03022	1.43233839
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.41608573
29	Olfactory transduction_Homo sapiens_hsa04740	1.41029665
30	Glutamatergic synapse_Homo sapiens_hsa04724	1.37623685
31	RNA polymerase_Homo sapiens_hsa03020	1.33806442
32	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.32294232
33	Parkinsons disease_Homo sapiens_hsa05012	1.28254491
34	Propanoate metabolism_Homo sapiens_hsa00640	1.25690916
35	Insulin secretion_Homo sapiens_hsa04911	1.24337464
36	Circadian entrainment_Homo sapiens_hsa04713	1.23784700
37	ABC transporters_Homo sapiens_hsa02010	1.21508593
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.17584002
39	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.11354588
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06248429
41	One carbon pool by folate_Homo sapiens_hsa00670	1.04104825
42	Serotonergic synapse_Homo sapiens_hsa04726	1.03096889
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.02758887
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02360262
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01522729
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99966324
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.99054869
48	Calcium signaling pathway_Homo sapiens_hsa04020	0.96044987
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.94661569
50	RNA degradation_Homo sapiens_hsa03018	0.94312753
51	Sulfur relay system_Homo sapiens_hsa04122	0.93400035
52	Huntingtons disease_Homo sapiens_hsa05016	0.90782772
53	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.87356941
54	Peroxisome_Homo sapiens_hsa04146	0.85583876
55	Retinol metabolism_Homo sapiens_hsa00830	0.80151211
56	Alzheimers disease_Homo sapiens_hsa05010	0.78191158
57	Dopaminergic synapse_Homo sapiens_hsa04728	0.77481102
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.76917255
59	Cocaine addiction_Homo sapiens_hsa05030	0.75201928
60	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.74142432
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73700344
62	Salivary secretion_Homo sapiens_hsa04970	0.73245959
63	Asthma_Homo sapiens_hsa05310	0.73039119
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.71879291
65	Protein export_Homo sapiens_hsa03060	0.71048159
66	Cholinergic synapse_Homo sapiens_hsa04725	0.67933253
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67555656
68	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67323420
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.66487036
70	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.65980186
71	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.64209903
72	Amphetamine addiction_Homo sapiens_hsa05031	0.62167167
73	Fatty acid degradation_Homo sapiens_hsa00071	0.61071459
74	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61029863
75	Non-homologous end-joining_Homo sapiens_hsa03450	0.59659553
76	Sulfur metabolism_Homo sapiens_hsa00920	0.57989443
77	Histidine metabolism_Homo sapiens_hsa00340	0.56612773
78	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.54531798
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.53894522
80	Circadian rhythm_Homo sapiens_hsa04710	0.53177990
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.52335563
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.49108187
83	Long-term depression_Homo sapiens_hsa04730	0.48812199
84	Purine metabolism_Homo sapiens_hsa00230	0.48344234
85	Metabolic pathways_Homo sapiens_hsa01100	0.42152333
86	Basal cell carcinoma_Homo sapiens_hsa05217	0.41605649
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.40882374
88	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.40850297
89	Primary immunodeficiency_Homo sapiens_hsa05340	0.39712801
90	Alcoholism_Homo sapiens_hsa05034	0.38198438
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.38116980
92	Renin secretion_Homo sapiens_hsa04924	0.37992184
93	Lysine degradation_Homo sapiens_hsa00310	0.37074508
94	Collecting duct acid secretion_Homo sapiens_hsa04966	0.36169748
95	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.35888678
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.33931189
97	Gastric acid secretion_Homo sapiens_hsa04971	0.31881514
98	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.29292746
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.28502775
100	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.26968700

ZNF546

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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