ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.65477210
2	neural tube formation (GO:0001841)	5.55441780
3	response to pheromone (GO:0019236)	4.41909091
4	pyrimidine nucleobase catabolic process (GO:0006208)	4.24020866
5	protein localization to cilium (GO:0061512)	3.95451269
6	behavioral response to ethanol (GO:0048149)	3.93277902
7	piRNA metabolic process (GO:0034587)	3.92204322
8	fucose catabolic process (GO:0019317)	3.86993499
9	L-fucose metabolic process (GO:0042354)	3.86993499
10	L-fucose catabolic process (GO:0042355)	3.86993499
11	limb bud formation (GO:0060174)	3.65291384
12	axoneme assembly (GO:0035082)	3.61976448
13	indole-containing compound catabolic process (GO:0042436)	3.60391351
14	indolalkylamine catabolic process (GO:0046218)	3.60391351
15	tryptophan catabolic process (GO:0006569)	3.60391351
16	nonmotile primary cilium assembly (GO:0035058)	3.54283565
17	RNA destabilization (GO:0050779)	3.50241830
18	nucleobase catabolic process (GO:0046113)	3.40431937
19	somite development (GO:0061053)	3.38639990
20	intraciliary transport (GO:0042073)	3.35089989
21	indolalkylamine metabolic process (GO:0006586)	3.31438603
22	DNA double-strand break processing (GO:0000729)	3.28135383
23	tryptophan metabolic process (GO:0006568)	3.26820582
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.24395153
25	kidney morphogenesis (GO:0060993)	3.21960530
26	gamma-aminobutyric acid transport (GO:0015812)	3.20724010
27	cilium morphogenesis (GO:0060271)	3.13249810
28	protein-cofactor linkage (GO:0018065)	3.03764556
29	cornea development in camera-type eye (GO:0061303)	3.03280802
30	cAMP catabolic process (GO:0006198)	2.98184403
31	synaptic transmission, cholinergic (GO:0007271)	2.96884802
32	regulation of telomere maintenance (GO:0032204)	2.96780393
33	negative regulation of telomere maintenance (GO:0032205)	2.96563762
34	glial cell proliferation (GO:0014009)	2.94404705
35	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.94263317
36	neuronal action potential (GO:0019228)	2.94039180
37	spinal cord motor neuron differentiation (GO:0021522)	2.93369021
38	presynaptic membrane assembly (GO:0097105)	2.93355941
39	single strand break repair (GO:0000012)	2.93180751
40	retinal cone cell development (GO:0046549)	2.92366002
41	embryonic epithelial tube formation (GO:0001838)	2.91733779
42	male meiosis (GO:0007140)	2.91082582
43	protein prenylation (GO:0018342)	2.87735266
44	prenylation (GO:0097354)	2.87735266
45	protein K11-linked deubiquitination (GO:0035871)	2.87603206
46	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.87209995
47	somite rostral/caudal axis specification (GO:0032525)	2.86350859
48	cilium organization (GO:0044782)	2.85957787
49	regulation of meiosis I (GO:0060631)	2.85372005
50	DNA methylation involved in gamete generation (GO:0043046)	2.82298050
51	regulation of cilium movement (GO:0003352)	2.78244948
52	protein polyglutamylation (GO:0018095)	2.77320720
53	cilium assembly (GO:0042384)	2.75362570
54	neuron cell-cell adhesion (GO:0007158)	2.75343433
55	reflex (GO:0060004)	2.73704246
56	replication fork processing (GO:0031297)	2.73694646
57	epithelial cilium movement (GO:0003351)	2.72921783
58	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.71878173
59	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.71878173
60	regulation of translation, ncRNA-mediated (GO:0045974)	2.71878173
61	kynurenine metabolic process (GO:0070189)	2.71411259
62	resolution of meiotic recombination intermediates (GO:0000712)	2.69821437
63	epithelial tube formation (GO:0072175)	2.65728905
64	inner ear receptor stereocilium organization (GO:0060122)	2.64688886
65	establishment of protein localization to Golgi (GO:0072600)	2.64447619
66	cilium or flagellum-dependent cell motility (GO:0001539)	2.63916890
67	cyclic nucleotide catabolic process (GO:0009214)	2.62505355
68	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.61476269
69	centriole replication (GO:0007099)	2.57816959
70	cell differentiation in spinal cord (GO:0021515)	2.56753074
71	activated T cell proliferation (GO:0050798)	2.56481347
72	ubiquinone metabolic process (GO:0006743)	2.56275717
73	dopamine biosynthetic process (GO:0042416)	2.55680195
74	indole-containing compound metabolic process (GO:0042430)	2.55069494
75	regulation of telomere maintenance via telomerase (GO:0032210)	2.54344100
76	cellular ketone body metabolic process (GO:0046950)	2.53617475
77	amine catabolic process (GO:0009310)	2.52696303
78	cellular biogenic amine catabolic process (GO:0042402)	2.52696303
79	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.52627146
80	platelet dense granule organization (GO:0060155)	2.52336294
81	keratinocyte development (GO:0003334)	2.50551512
82	spinal cord development (GO:0021510)	2.50214372
83	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.49377549
84	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.49341378
85	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.49341378
86	rRNA catabolic process (GO:0016075)	2.49263532
87	detection of light stimulus involved in sensory perception (GO:0050962)	2.49034509
88	detection of light stimulus involved in visual perception (GO:0050908)	2.49034509
89	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.48670063
90	presynaptic membrane organization (GO:0097090)	2.48407452
91	negative regulation of interleukin-1 beta production (GO:0032691)	2.47778057
92	preassembly of GPI anchor in ER membrane (GO:0016254)	2.47627738
93	seminiferous tubule development (GO:0072520)	2.44990463
94	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.44490582
95	sympathetic nervous system development (GO:0048485)	2.43044759
96	microtubule anchoring (GO:0034453)	2.40672468
97	protein targeting to Golgi (GO:0000042)	2.39796803
98	reciprocal DNA recombination (GO:0035825)	2.39768397
99	reciprocal meiotic recombination (GO:0007131)	2.39768397
100	spermatid nucleus differentiation (GO:0007289)	2.39596492

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.09255601
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.98107950
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.91059077
4	VDR_22108803_ChIP-Seq_LS180_Human	2.79902463
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.78804185
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.74160921
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.73338228
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.69861131
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.57593454
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.56612493
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.55893242
12	FUS_26573619_Chip-Seq_HEK293_Human	2.47705815
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.43468536
14	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.36091700
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34715940
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.31732925
17	EWS_26573619_Chip-Seq_HEK293_Human	2.20202325
18	P300_19829295_ChIP-Seq_ESCs_Human	2.14974731
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.13410887
20	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.92184751
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.88094376
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.83876062
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.76742182
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.74239373
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.73563365
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70700564
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.70589131
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.68241456
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.66982621
30	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.66918211
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.64362708
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.64362708
33	STAT3_23295773_ChIP-Seq_U87_Human	1.64361731
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.61366810
35	AR_25329375_ChIP-Seq_VCAP_Human	1.57175821
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.54963491
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52614406
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51324415
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.50475661
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48962707
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.45938423
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45498708
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.45498708
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.44587175
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.41723649
46	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.41432813
47	RNF2_27304074_Chip-Seq_NSC_Mouse	1.39853216
48	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39386234
49	TCF4_23295773_ChIP-Seq_U87_Human	1.39241846
50	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37834624
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37442882
52	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.37162390
53	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.35116019
54	* MYC_18940864_ChIP-ChIP_HL60_Human	1.34396206
55	* ELK1_19687146_ChIP-ChIP_HELA_Human	1.34290779
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.32914234
57	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.29337486
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28971400
59	AR_21572438_ChIP-Seq_LNCaP_Human	1.28322840
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28108272
61	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.27044016
62	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.25011313
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23337707
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23337707
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22993115
66	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.22944138
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22780311
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22409411
69	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.22341658
70	REST_21632747_ChIP-Seq_MESCs_Mouse	1.19955280
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19279329
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.18411934
73	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17997879
74	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.16776479
75	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.16413847
76	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15027150
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13888401
78	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13654645
79	* EST1_17652178_ChIP-ChIP_JURKAT_Human	1.13279898
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12358797
81	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11036384
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10275928
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09687582
84	* VDR_23849224_ChIP-Seq_CD4+_Human	1.09259302
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08336586
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04826064
87	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04826064
88	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04759817
89	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.03543004
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01749998
91	AR_20517297_ChIP-Seq_VCAP_Human	0.99756544
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99579760
93	NCOR_22424771_ChIP-Seq_293T_Human	0.98463915
94	KDM2B_26808549_Chip-Seq_REH_Human	0.98118803
95	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.97740895
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97014134
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.96872577
98	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.95086538
99	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.95007584
100	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.93760429

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.26649841
2	MP0008877_abnormal_DNA_methylation	2.96907465
3	MP0000569_abnormal_digit_pigmentation	2.70898765
4	MP0002638_abnormal_pupillary_reflex	2.33421525
5	MP0005551_abnormal_eye_electrophysiolog	2.22323395
6	MP0004043_abnormal_pH_regulation	2.18347092
7	MP0004142_abnormal_muscle_tone	2.09486971
8	MP0005646_abnormal_pituitary_gland	2.06718311
9	MP0003136_yellow_coat_color	2.03158018
10	MP0002822_catalepsy	2.00082990
11	MP0006072_abnormal_retinal_apoptosis	1.98547982
12	MP0005253_abnormal_eye_physiology	1.97556823
13	MP0001986_abnormal_taste_sensitivity	1.96658687
14	MP0005645_abnormal_hypothalamus_physiol	1.91981133
15	MP0003195_calcinosis	1.87483023
16	MP0002653_abnormal_ependyma_morphology	1.83963033
17	MP0008995_early_reproductive_senescence	1.82961330
18	MP0003880_abnormal_central_pattern	1.82543751
19	MP0008058_abnormal_DNA_repair	1.80356657
20	MP0000631_abnormal_neuroendocrine_gland	1.78985870
21	MP0004885_abnormal_endolymph	1.74406162
22	MP0001984_abnormal_olfaction	1.72278348
23	MP0002928_abnormal_bile_duct	1.71930281
24	MP0003121_genomic_imprinting	1.68431663
25	MP0001968_abnormal_touch/_nociception	1.68415758
26	MP0003122_maternal_imprinting	1.67410270
27	MP0009046_muscle_twitch	1.67030290
28	MP0001486_abnormal_startle_reflex	1.64336657
29	MP0009745_abnormal_behavioral_response	1.63933198
30	MP0000778_abnormal_nervous_system	1.63241336
31	MP0002876_abnormal_thyroid_physiology	1.54849046
32	MP0002735_abnormal_chemical_nociception	1.54359480
33	MP0006276_abnormal_autonomic_nervous	1.53275543
34	MP0002138_abnormal_hepatobiliary_system	1.52079432
35	MP0001485_abnormal_pinna_reflex	1.51686274
36	MP0001529_abnormal_vocalization	1.49135916
37	MP0005084_abnormal_gallbladder_morpholo	1.45811366
38	MP0008057_abnormal_DNA_replication	1.45712650
39	MP0002272_abnormal_nervous_system	1.44749011
40	MP0000427_abnormal_hair_cycle	1.43135273
41	MP0004147_increased_porphyrin_level	1.41621853
42	MP0002837_dystrophic_cardiac_calcinosis	1.41380712
43	MP0000372_irregular_coat_pigmentation	1.39999882
44	MP0006292_abnormal_olfactory_placode	1.36407182
45	MP0002736_abnormal_nociception_after	1.34179040
46	MP0002572_abnormal_emotion/affect_behav	1.31926777
47	MP0002938_white_spotting	1.31421883
48	MP0003646_muscle_fatigue	1.30985765
49	MP0002751_abnormal_autonomic_nervous	1.26997533
50	MP0004133_heterotaxia	1.25458229
51	MP0003787_abnormal_imprinting	1.24245612
52	MP0004742_abnormal_vestibular_system	1.23408353
53	MP0005174_abnormal_tail_pigmentation	1.20324493
54	MP0003011_delayed_dark_adaptation	1.18743290
55	MP0003567_abnormal_fetal_cardiomyocyte	1.18012388
56	MP0002067_abnormal_sensory_capabilities	1.17142360
57	MP0002557_abnormal_social/conspecific_i	1.14999168
58	MP0002063_abnormal_learning/memory/cond	1.14513777
59	MP0003890_abnormal_embryonic-extraembry	1.14325550
60	MP0001188_hyperpigmentation	1.13667554
61	MP0003635_abnormal_synaptic_transmissio	1.09437731
62	MP0002095_abnormal_skin_pigmentation	1.06899183
63	MP0004924_abnormal_behavior	1.06292616
64	MP0005386_behavior/neurological_phenoty	1.06292616
65	MP0001502_abnormal_circadian_rhythm	1.03765822
66	MP0003698_abnormal_male_reproductive	1.03704348
67	MP0001501_abnormal_sleep_pattern	1.02105136
68	MP0005195_abnormal_posterior_eye	1.01910735
69	MP0000026_abnormal_inner_ear	1.00862123
70	MP0002064_seizures	1.00436071
71	MP0001929_abnormal_gametogenesis	0.99377046
72	MP0000647_abnormal_sebaceous_gland	0.98282362
73	MP0008875_abnormal_xenobiotic_pharmacok	0.96426853
74	MP0002277_abnormal_respiratory_mucosa	0.95643533
75	MP0001324_abnormal_eye_pigmentation	0.94421509
76	MP0001970_abnormal_pain_threshold	0.94403617
77	MP0002282_abnormal_trachea_morphology	0.93485211
78	MP0002752_abnormal_somatic_nervous	0.92022129
79	MP0002184_abnormal_innervation	0.92018838
80	MP0008872_abnormal_physiological_respon	0.91532619
81	MP0009697_abnormal_copulation	0.88194812
82	MP0002009_preneoplasia	0.87730676
83	MP0002229_neurodegeneration	0.87694492
84	MP0003283_abnormal_digestive_organ	0.87263706
85	MP0002733_abnormal_thermal_nociception	0.86213061
86	MP0008789_abnormal_olfactory_epithelium	0.86195170
87	MP0001963_abnormal_hearing_physiology	0.83215281
88	MP0005171_absent_coat_pigmentation	0.82237059
89	MP0005391_vision/eye_phenotype	0.80264331
90	MP0004215_abnormal_myocardial_fiber	0.79500538
91	MP0002909_abnormal_adrenal_gland	0.78940625
92	MP0003786_premature_aging	0.78624115
93	MP0000383_abnormal_hair_follicle	0.77970974
94	MP0002882_abnormal_neuron_morphology	0.77180584
95	MP0003943_abnormal_hepatobiliary_system	0.77103505
96	MP0003137_abnormal_impulse_conducting	0.75286782
97	MP0005220_abnormal_exocrine_pancreas	0.74499343
98	MP0001764_abnormal_homeostasis	0.74012652
99	MP0001873_stomach_inflammation	0.73873884
100	MP0005075_abnormal_melanosome_morpholog	0.72392087

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.00292889
2	Nephronophthisis (HP:0000090)	3.68947556
3	True hermaphroditism (HP:0010459)	3.67020214
4	Abnormality of midbrain morphology (HP:0002418)	3.60272534
5	Molar tooth sign on MRI (HP:0002419)	3.60272534
6	Congenital stationary night blindness (HP:0007642)	3.53298018
7	Hyperventilation (HP:0002883)	3.51655279
8	Medial flaring of the eyebrow (HP:0010747)	3.49047181
9	Pancreatic fibrosis (HP:0100732)	3.46978900
10	Abnormality of the renal medulla (HP:0100957)	3.19845193
11	Chronic hepatic failure (HP:0100626)	2.83843642
12	Abnormality of the renal cortex (HP:0011035)	2.80581781
13	Attenuation of retinal blood vessels (HP:0007843)	2.75329758
14	Gait imbalance (HP:0002141)	2.74922399
15	Lissencephaly (HP:0001339)	2.71814911
16	Nephrogenic diabetes insipidus (HP:0009806)	2.70654887
17	Abnormality of B cell number (HP:0010975)	2.70116472
18	Congenital primary aphakia (HP:0007707)	2.66797948
19	B lymphocytopenia (HP:0010976)	2.61502272
20	Large for gestational age (HP:0001520)	2.57217758
21	Thyroiditis (HP:0100646)	2.57163513
22	Cystic liver disease (HP:0006706)	2.56289255
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.51177058
24	Progressive inability to walk (HP:0002505)	2.49742583
25	Type II lissencephaly (HP:0007260)	2.49474367
26	Severe combined immunodeficiency (HP:0004430)	2.44365906
27	Widely spaced teeth (HP:0000687)	2.38937216
28	Patellar aplasia (HP:0006443)	2.38032330
29	Bile duct proliferation (HP:0001408)	2.37691547
30	Abnormal biliary tract physiology (HP:0012439)	2.37691547
31	Inability to walk (HP:0002540)	2.37379140
32	Panhypogammaglobulinemia (HP:0003139)	2.36811942
33	Abolished electroretinogram (ERG) (HP:0000550)	2.35253316
34	Pendular nystagmus (HP:0012043)	2.34732748
35	Hypothermia (HP:0002045)	2.32744002
36	Renal cortical cysts (HP:0000803)	2.28007914
37	Gaze-evoked nystagmus (HP:0000640)	2.26285482
38	Genetic anticipation (HP:0003743)	2.26232408
39	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.21900645
40	Intestinal atresia (HP:0011100)	2.21887705
41	Stomach cancer (HP:0012126)	2.20988954
42	Birth length less than 3rd percentile (HP:0003561)	2.20481892
43	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.19309742
44	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.19309742
45	Postaxial foot polydactyly (HP:0001830)	2.18020331
46	Aplasia/Hypoplasia of the patella (HP:0006498)	2.17482465
47	Broad-based gait (HP:0002136)	2.14652109
48	Keratoconus (HP:0000563)	2.12214328
49	Increased corneal curvature (HP:0100692)	2.12214328
50	Absent/shortened dynein arms (HP:0200106)	2.09693573
51	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.09693573
52	Progressive cerebellar ataxia (HP:0002073)	2.09531333
53	Fair hair (HP:0002286)	2.08162464
54	Congenital hepatic fibrosis (HP:0002612)	2.05705728
55	Tubulointerstitial nephritis (HP:0001970)	2.03507403
56	Absent speech (HP:0001344)	2.02860486
57	Decreased central vision (HP:0007663)	2.01165748
58	Hemiparesis (HP:0001269)	2.01000340
59	Oligodactyly (hands) (HP:0001180)	2.00853293
60	Genital tract atresia (HP:0001827)	1.98691505
61	Febrile seizures (HP:0002373)	1.98489664
62	Constricted visual fields (HP:0001133)	1.98470387
63	Sclerocornea (HP:0000647)	1.97951689
64	Abnormality of alanine metabolism (HP:0010916)	1.96470708
65	Hyperalaninemia (HP:0003348)	1.96470708
66	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.96470708
67	Hypoplastic iliac wings (HP:0002866)	1.96356131
68	Drooling (HP:0002307)	1.95784486
69	Anencephaly (HP:0002323)	1.94034546
70	Limb dystonia (HP:0002451)	1.93017945
71	Vaginal atresia (HP:0000148)	1.91716181
72	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.91534882
73	Male pseudohermaphroditism (HP:0000037)	1.89671992
74	Postaxial hand polydactyly (HP:0001162)	1.88673838
75	Congenital, generalized hypertrichosis (HP:0004540)	1.87185286
76	Brushfield spots (HP:0001088)	1.87137107
77	Poor coordination (HP:0002370)	1.83705805
78	Short tibia (HP:0005736)	1.81657012
79	Excessive salivation (HP:0003781)	1.81527775
80	Retinal dysplasia (HP:0007973)	1.81255071
81	Duplicated collecting system (HP:0000081)	1.80086573
82	Abnormality of the labia minora (HP:0012880)	1.79033114
83	Furrowed tongue (HP:0000221)	1.77695017
84	Abnormality of the renal collecting system (HP:0004742)	1.77233161
85	Methylmalonic acidemia (HP:0002912)	1.76779927
86	Agitation (HP:0000713)	1.75572206
87	Colon cancer (HP:0003003)	1.75490065
88	Combined immunodeficiency (HP:0005387)	1.75474768
89	Cerebellar dysplasia (HP:0007033)	1.74254419
90	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.73991051
91	Abnormality of the corticospinal tract (HP:0002492)	1.72830467
92	Abnormal drinking behavior (HP:0030082)	1.71171578
93	Polydipsia (HP:0001959)	1.71171578
94	Neonatal respiratory distress (HP:0002643)	1.70691630
95	Tubular atrophy (HP:0000092)	1.70170916
96	Hypoproteinemia (HP:0003075)	1.70116379
97	Pachygyria (HP:0001302)	1.68656971
98	Abnormal respiratory epithelium morphology (HP:0012253)	1.67375048
99	Abnormal respiratory motile cilium morphology (HP:0005938)	1.67375048
100	Stomatitis (HP:0010280)	1.65822730

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.13558778
2	MAP4K2	3.17294810
3	NUAK1	3.04404795
4	WNK3	3.00793675
5	LATS1	2.57766696
6	CASK	2.42578466
7	BMPR1B	2.39495934
8	ADRBK2	2.12339375
9	TAOK3	2.10241332
10	INSRR	2.05895551
11	MAP3K4	2.00927366
12	NLK	1.98590263
13	ACVR1B	1.96927869
14	PINK1	1.93394558
15	MAPK13	1.91122865
16	EIF2AK3	1.75164111
17	SIK2	1.73362252
18	ZAK	1.71168410
19	MKNK2	1.67885742
20	IRAK1	1.60647753
21	PNCK	1.50865345
22	TRIM28	1.45920675
23	MARK1	1.44175255
24	CDK3	1.42974327
25	GRK1	1.42972915
26	MAP2K7	1.32827045
27	ERBB3	1.30574117
28	CSNK1G1	1.28049957
29	IRAK2	1.27646153
30	BCR	1.17406247
31	PAK3	1.15349722
32	MAPK15	1.11977865
33	TEC	1.10021268
34	MKNK1	1.08151000
35	CAMKK2	1.02966298
36	TGFBR1	1.01486399
37	RPS6KA4	1.01007112
38	DYRK2	0.99804187
39	SGK2	0.98705181
40	CDK19	0.96187176
41	TXK	0.95263783
42	NTRK2	0.95012791
43	NTRK3	0.92284884
44	BRD4	0.91225166
45	OXSR1	0.88596060
46	AKT3	0.86287294
47	DYRK1A	0.85315766
48	RPS6KA5	0.84900425
49	PRKCG	0.84503091
50	BRSK2	0.83607223
51	MAP2K4	0.82390756
52	CSNK1G2	0.80949362
53	STK38L	0.80146951
54	EPHA3	0.79397286
55	VRK1	0.77945841
56	PASK	0.76596156
57	TLK1	0.74462360
58	WNK4	0.73695080
59	STK39	0.73513708
60	STK3	0.73405627
61	KIT	0.72859080
62	PLK4	0.70771880
63	TNIK	0.68191223
64	MAPK7	0.66182230
65	CDC7	0.64767919
66	PRKCE	0.63395156
67	ITK	0.62648596
68	CSNK1G3	0.62220079
69	DAPK2	0.60350370
70	SGK494	0.59706839
71	SGK223	0.59706839
72	CSNK1A1L	0.58569993
73	MARK3	0.57133252
74	NEK2	0.54722456
75	KSR1	0.54323184
76	PLK2	0.53372896
77	STK11	0.52986549
78	TIE1	0.52175668
79	ADRBK1	0.50763664
80	PIK3CA	0.48292388
81	WEE1	0.45693251
82	OBSCN	0.44365051
83	BCKDK	0.43301395
84	EPHB2	0.42520386
85	DYRK3	0.41689045
86	FGFR2	0.41462519
87	EPHA4	0.40643643
88	CAMK2A	0.38761484
89	PRKCZ	0.38138433
90	PRKCQ	0.37842504
91	SYK	0.37753169
92	MAPKAPK3	0.37453402
93	BTK	0.36890381
94	MINK1	0.35534805
95	CAMK1	0.35018770
96	CSNK1D	0.34496403
97	TSSK6	0.33032958
98	PTK2B	0.33000202
99	PKN1	0.32774774
100	CHUK	0.30582816

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.94633054
2	Nicotine addiction_Homo sapiens_hsa05033	2.80898737
3	Phototransduction_Homo sapiens_hsa04744	2.38963535
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.36595565
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.30447265
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.29541330
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.24577682
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.22687752
9	Butanoate metabolism_Homo sapiens_hsa00650	2.17106595
10	Basal transcription factors_Homo sapiens_hsa03022	2.12593303
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.11186793
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.00609916
13	Regulation of autophagy_Homo sapiens_hsa04140	1.80970323
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.80066464
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.78444293
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.74070530
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.69683639
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.66430862
19	Morphine addiction_Homo sapiens_hsa05032	1.65224237
20	Taste transduction_Homo sapiens_hsa04742	1.57025256
21	RNA degradation_Homo sapiens_hsa03018	1.55983335
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.54434982
23	Homologous recombination_Homo sapiens_hsa03440	1.53717834
24	Protein export_Homo sapiens_hsa03060	1.47848314
25	Olfactory transduction_Homo sapiens_hsa04740	1.45788298
26	Non-homologous end-joining_Homo sapiens_hsa03450	1.44973565
27	GABAergic synapse_Homo sapiens_hsa04727	1.44256112
28	Circadian entrainment_Homo sapiens_hsa04713	1.42523764
29	Primary immunodeficiency_Homo sapiens_hsa05340	1.42398379
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.40241546
31	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.39012305
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.33874941
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.30636397
34	ABC transporters_Homo sapiens_hsa02010	1.28128910
35	Caffeine metabolism_Homo sapiens_hsa00232	1.26785436
36	Peroxisome_Homo sapiens_hsa04146	1.26066034
37	Glutamatergic synapse_Homo sapiens_hsa04724	1.25068228
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.23597209
39	Propanoate metabolism_Homo sapiens_hsa00640	1.20079769
40	Serotonergic synapse_Homo sapiens_hsa04726	1.15611113
41	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.11785753
42	Circadian rhythm_Homo sapiens_hsa04710	1.10931102
43	Long-term depression_Homo sapiens_hsa04730	1.03263877
44	Asthma_Homo sapiens_hsa05310	0.99912330
45	RNA polymerase_Homo sapiens_hsa03020	0.96371021
46	Insulin secretion_Homo sapiens_hsa04911	0.95138832
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94935156
48	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.88836801
49	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.88421930
50	Type I diabetes mellitus_Homo sapiens_hsa04940	0.87600739
51	Oxidative phosphorylation_Homo sapiens_hsa00190	0.86546390
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82223059
53	Salivary secretion_Homo sapiens_hsa04970	0.82058536
54	Dopaminergic synapse_Homo sapiens_hsa04728	0.79932481
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78036614
56	Histidine metabolism_Homo sapiens_hsa00340	0.77318104
57	Cocaine addiction_Homo sapiens_hsa05030	0.76489402
58	Cholinergic synapse_Homo sapiens_hsa04725	0.74516488
59	Amphetamine addiction_Homo sapiens_hsa05031	0.74080149
60	Calcium signaling pathway_Homo sapiens_hsa04020	0.70259990
61	Renin secretion_Homo sapiens_hsa04924	0.67110206
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66226654
63	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.65916661
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.60661241
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57775570
66	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.57049129
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.56372486
68	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.56284744
69	Nucleotide excision repair_Homo sapiens_hsa03420	0.55822266
70	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.54280053
71	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.54127702
72	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.53486663
73	One carbon pool by folate_Homo sapiens_hsa00670	0.53154588
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.53105495
75	Lysine degradation_Homo sapiens_hsa00310	0.53100720
76	Parkinsons disease_Homo sapiens_hsa05012	0.51841694
77	Purine metabolism_Homo sapiens_hsa00230	0.51013834
78	Graft-versus-host disease_Homo sapiens_hsa05332	0.48671654
79	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48643211
80	Allograft rejection_Homo sapiens_hsa05330	0.48623255
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.48117275
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48052579
83	Type II diabetes mellitus_Homo sapiens_hsa04930	0.46124931
84	cAMP signaling pathway_Homo sapiens_hsa04024	0.41989366
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.41501256
86	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.40612014
87	Retinol metabolism_Homo sapiens_hsa00830	0.40171232
88	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.39909202
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39680713
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39533801
91	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.38812639
92	RNA transport_Homo sapiens_hsa03013	0.36910543
93	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.35903472
94	FoxO signaling pathway_Homo sapiens_hsa04068	0.35070939
95	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.34953696
96	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.34486019
97	Fatty acid elongation_Homo sapiens_hsa00062	0.32664944
98	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31869872
99	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.30497726
100	Cardiac muscle contraction_Homo sapiens_hsa04260	0.29462227

ZNF548

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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