ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neural tube formation (GO:0001841)	4.34212259
2	behavioral response to nicotine (GO:0035095)	4.21006313
3	cell wall macromolecule metabolic process (GO:0044036)	4.06740858
4	fucose catabolic process (GO:0019317)	3.94533296
5	L-fucose metabolic process (GO:0042354)	3.94533296
6	L-fucose catabolic process (GO:0042355)	3.94533296
7	response to pheromone (GO:0019236)	3.84556488
8	negative regulation of mast cell activation (GO:0033004)	3.71686257
9	pyrimidine nucleobase catabolic process (GO:0006208)	3.69019100
10	cornea development in camera-type eye (GO:0061303)	3.51442420
11	protein K11-linked deubiquitination (GO:0035871)	3.44533087
12	retinal cone cell development (GO:0046549)	3.32482916
13	presynaptic membrane assembly (GO:0097105)	3.31871847
14	nonmotile primary cilium assembly (GO:0035058)	3.28527312
15	regulation of meiosis I (GO:0060631)	3.25366360
16	piRNA metabolic process (GO:0034587)	3.25004242
17	DNA double-strand break processing (GO:0000729)	3.23175478
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.23040073
19	platelet dense granule organization (GO:0060155)	3.19935744
20	behavioral response to ethanol (GO:0048149)	3.17413803
21	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.14736682
22	regulation of acrosome reaction (GO:0060046)	3.09016708
23	detection of light stimulus involved in sensory perception (GO:0050962)	3.02773964
24	detection of light stimulus involved in visual perception (GO:0050908)	3.02773964
25	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.01770289
26	regulation of translation, ncRNA-mediated (GO:0045974)	3.01770289
27	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.01770289
28	gamma-aminobutyric acid transport (GO:0015812)	3.01752349
29	cilium or flagellum-dependent cell motility (GO:0001539)	3.01265799
30	nucleobase catabolic process (GO:0046113)	2.99958382
31	cilium morphogenesis (GO:0060271)	2.96219378
32	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.92749049
33	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.91609567
34	indolalkylamine metabolic process (GO:0006586)	2.88800178
35	ubiquinone biosynthetic process (GO:0006744)	2.87673882
36	epithelial cilium movement (GO:0003351)	2.85271634
37	ubiquinone metabolic process (GO:0006743)	2.84289159
38	presynaptic membrane organization (GO:0097090)	2.83617314
39	water-soluble vitamin biosynthetic process (GO:0042364)	2.82440598
40	photoreceptor cell maintenance (GO:0045494)	2.82078233
41	multicellular organism reproduction (GO:0032504)	2.80826918
42	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.79349687
43	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.74011687
44	establishment of protein localization to Golgi (GO:0072600)	2.73935737
45	limb bud formation (GO:0060174)	2.73825049
46	regulation of female gonad development (GO:2000194)	2.73374322
47	DNA deamination (GO:0045006)	2.70496316
48	cilium organization (GO:0044782)	2.70294115
49	regulation of action potential (GO:0098900)	2.67625377
50	photoreceptor cell development (GO:0042461)	2.67607338
51	DNA methylation involved in gamete generation (GO:0043046)	2.66110704
52	tryptophan catabolic process (GO:0006569)	2.65191393
53	indole-containing compound catabolic process (GO:0042436)	2.65191393
54	indolalkylamine catabolic process (GO:0046218)	2.65191393
55	replication fork processing (GO:0031297)	2.63170886
56	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.62805029
57	axoneme assembly (GO:0035082)	2.61161359
58	cilium assembly (GO:0042384)	2.60396655
59	recombinational repair (GO:0000725)	2.59314487
60	sulfation (GO:0051923)	2.58835790
61	intraciliary transport (GO:0042073)	2.58545009
62	preassembly of GPI anchor in ER membrane (GO:0016254)	2.58453886
63	embryonic epithelial tube formation (GO:0001838)	2.58236756
64	histone H3-K9 methylation (GO:0051567)	2.57439385
65	kynurenine metabolic process (GO:0070189)	2.55086341
66	prenylation (GO:0097354)	2.54642584
67	protein prenylation (GO:0018342)	2.54642584
68	head development (GO:0060322)	2.54314020
69	double-strand break repair via homologous recombination (GO:0000724)	2.54214652
70	cilium movement (GO:0003341)	2.53748716
71	DNA demethylation (GO:0080111)	2.53600125
72	regulation of telomere maintenance (GO:0032204)	2.50597293
73	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.48816920
74	DNA integration (GO:0015074)	2.48548182
75	somite development (GO:0061053)	2.48008476
76	reciprocal DNA recombination (GO:0035825)	2.47349098
77	reciprocal meiotic recombination (GO:0007131)	2.47349098
78	monoubiquitinated protein deubiquitination (GO:0035520)	2.46404645
79	microtubule anchoring (GO:0034453)	2.46176975
80	eye photoreceptor cell development (GO:0042462)	2.45281253
81	protein localization to cilium (GO:0061512)	2.45244461
82	anterograde synaptic vesicle transport (GO:0048490)	2.45053549
83	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.44319235
84	positive regulation of developmental pigmentation (GO:0048087)	2.44195996
85	neuron cell-cell adhesion (GO:0007158)	2.44148130
86	pyrimidine dimer repair (GO:0006290)	2.43178922
87	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.41955567
88	peptidyl-histidine modification (GO:0018202)	2.41654001
89	epithelial tube formation (GO:0072175)	2.41605720
90	centriole replication (GO:0007099)	2.41554947
91	inositol phosphate catabolic process (GO:0071545)	2.41243621
92	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.40467218
93	kidney morphogenesis (GO:0060993)	2.39450066
94	neuronal action potential (GO:0019228)	2.38730252
95	male meiosis I (GO:0007141)	2.38473792
96	oxidative demethylation (GO:0070989)	2.37802975
97	rRNA catabolic process (GO:0016075)	2.37758841
98	central nervous system neuron axonogenesis (GO:0021955)	2.35924820
99	tryptophan metabolic process (GO:0006568)	2.35138654
100	olfactory bulb development (GO:0021772)	2.34131359

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	4.13745990
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.37804553
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.08245365
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.95375453
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.93570271
6	VDR_22108803_ChIP-Seq_LS180_Human	2.93486125
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.69135797
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.67627895
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.54472324
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.50920888
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.29516692
12	EWS_26573619_Chip-Seq_HEK293_Human	2.29231348
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.19923611
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.19236140
15	P300_19829295_ChIP-Seq_ESCs_Human	2.13391080
16	FUS_26573619_Chip-Seq_HEK293_Human	2.11272574
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.08708920
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.07738798
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.05317061
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.95716076
21	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.84335128
22	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.84209214
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82908821
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.82108409
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.81265830
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.75401884
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.73543424
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70006378
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69277103
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.69277103
31	STAT3_23295773_ChIP-Seq_U87_Human	1.68101725
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.63328329
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.61880654
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61448865
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56954259
36	TCF4_23295773_ChIP-Seq_U87_Human	1.56505085
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.54157126
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54157126
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.52256148
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.51553134
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.50844750
42	AR_25329375_ChIP-Seq_VCAP_Human	1.47781595
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.46424311
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.46055919
45	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.45646156
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45207528
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44617854
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39782233
49	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37783988
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37494906
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35904054
52	RUNX2_22187159_ChIP-Seq_PCA_Human	1.34648162
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33354702
54	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.32398161
55	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30402151
56	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.27859368
57	* EST1_17652178_ChIP-ChIP_JURKAT_Human	1.26837809
58	REST_21632747_ChIP-Seq_MESCs_Mouse	1.26268894
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23846095
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.23478719
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23469429
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23469429
63	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.23442639
64	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23091250
65	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22682235
66	ELK1_19687146_ChIP-ChIP_HELA_Human	1.22208024
67	AR_21572438_ChIP-Seq_LNCaP_Human	1.21127530
68	MYC_18940864_ChIP-ChIP_HL60_Human	1.20266619
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20170052
70	* GABP_17652178_ChIP-ChIP_JURKAT_Human	1.20052933
71	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.17989938
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17035168
73	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.15399733
74	VDR_23849224_ChIP-Seq_CD4+_Human	1.14140642
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13809949
76	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.13319402
77	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.11789817
78	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10909208
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.09811940
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08580475
81	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06622439
82	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.06610157
83	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04227144
84	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03556107
85	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03556107
86	AR_20517297_ChIP-Seq_VCAP_Human	1.01366660
87	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.00999717
88	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00994613
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00731269
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00679274
91	NCOR_22424771_ChIP-Seq_293T_Human	0.99877752
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98441260
93	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.98427864
94	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.97840606
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96067021
96	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.95809886
97	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95482579
98	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95322610
99	KDM2B_26808549_Chip-Seq_REH_Human	0.94638571
100	CDX2_22108803_ChIP-Seq_LS180_Human	0.94127402

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.30482849
2	MP0000569_abnormal_digit_pigmentation	3.48705077
3	MP0002102_abnormal_ear_morphology	3.10490128
4	MP0003787_abnormal_imprinting	2.84938139
5	MP0001968_abnormal_touch/_nociception	2.30696778
6	MP0005551_abnormal_eye_electrophysiolog	2.29265915
7	MP0008057_abnormal_DNA_replication	2.25741392
8	MP0003880_abnormal_central_pattern	2.18143691
9	MP0002736_abnormal_nociception_after	2.10874789
10	MP0003195_calcinosis	2.10544499
11	MP0005646_abnormal_pituitary_gland	2.03142285
12	MP0009046_muscle_twitch	2.01080798
13	MP0006292_abnormal_olfactory_placode	1.97749804
14	MP0006072_abnormal_retinal_apoptosis	1.91961657
15	MP0002638_abnormal_pupillary_reflex	1.87574634
16	MP0001986_abnormal_taste_sensitivity	1.75140922
17	MP0002653_abnormal_ependyma_morphology	1.74652798
18	MP0009745_abnormal_behavioral_response	1.74209998
19	MP0006276_abnormal_autonomic_nervous	1.71906877
20	MP0008058_abnormal_DNA_repair	1.69002935
21	MP0005253_abnormal_eye_physiology	1.67883898
22	MP0002735_abnormal_chemical_nociception	1.64197780
23	MP0003136_yellow_coat_color	1.62934210
24	MP0003718_maternal_effect	1.59884439
25	MP0005174_abnormal_tail_pigmentation	1.59830839
26	MP0002822_catalepsy	1.58946695
27	MP0004043_abnormal_pH_regulation	1.58666446
28	MP0003121_genomic_imprinting	1.57914898
29	MP0005645_abnormal_hypothalamus_physiol	1.55074248
30	MP0000516_abnormal_urinary_system	1.50941531
31	MP0005367_renal/urinary_system_phenotyp	1.50941531
32	MP0000427_abnormal_hair_cycle	1.50626185
33	MP0000631_abnormal_neuroendocrine_gland	1.48311055
34	MP0001486_abnormal_startle_reflex	1.47354262
35	MP0002272_abnormal_nervous_system	1.47191510
36	MP0004142_abnormal_muscle_tone	1.47025176
37	MP0003646_muscle_fatigue	1.46984552
38	MP0001984_abnormal_olfaction	1.44875572
39	MP0004924_abnormal_behavior	1.40813066
40	MP0005386_behavior/neurological_phenoty	1.40813066
41	MP0000778_abnormal_nervous_system	1.36824834
42	MP0003890_abnormal_embryonic-extraembry	1.34900520
43	MP0008872_abnormal_physiological_respon	1.32273050
44	MP0005423_abnormal_somatic_nervous	1.32047726
45	MP0004133_heterotaxia	1.30063323
46	MP0008789_abnormal_olfactory_epithelium	1.29423984
47	MP0002572_abnormal_emotion/affect_behav	1.29219846
48	MP0002837_dystrophic_cardiac_calcinosis	1.28206385
49	MP0001501_abnormal_sleep_pattern	1.27883430
50	MP0004885_abnormal_endolymph	1.25372426
51	MP0008995_early_reproductive_senescence	1.24330423
52	MP0005187_abnormal_penis_morphology	1.22454898
53	MP0002928_abnormal_bile_duct	1.22350416
54	MP0002064_seizures	1.20470351
55	MP0002095_abnormal_skin_pigmentation	1.20100633
56	MP0003119_abnormal_digestive_system	1.19791220
57	MP0005075_abnormal_melanosome_morpholog	1.19740027
58	MP0002067_abnormal_sensory_capabilities	1.17681627
59	MP0002557_abnormal_social/conspecific_i	1.17122374
60	MP0001529_abnormal_vocalization	1.16529087
61	MP0002938_white_spotting	1.16336500
62	MP0003635_abnormal_synaptic_transmissio	1.16197226
63	MP0005499_abnormal_olfactory_system	1.15588724
64	MP0005394_taste/olfaction_phenotype	1.15588724
65	MP0004147_increased_porphyrin_level	1.10313231
66	MP0000383_abnormal_hair_follicle	1.09370073
67	MP0001919_abnormal_reproductive_system	1.09302581
68	MP0002063_abnormal_learning/memory/cond	1.07873178
69	MP0001929_abnormal_gametogenesis	1.04914761
70	MP0005389_reproductive_system_phenotype	1.03936634
71	MP0005195_abnormal_posterior_eye	1.02694014
72	MP0001970_abnormal_pain_threshold	1.00500161
73	MP0002160_abnormal_reproductive_system	1.00143806
74	MP0000372_irregular_coat_pigmentation	1.00095632
75	MP0001188_hyperpigmentation	0.99477838
76	MP0003698_abnormal_male_reproductive	0.98073083
77	MP0002733_abnormal_thermal_nociception	0.96296527
78	MP0000647_abnormal_sebaceous_gland	0.93198701
79	MP0002752_abnormal_somatic_nervous	0.90718460
80	MP0001485_abnormal_pinna_reflex	0.89026754
81	MP0002210_abnormal_sex_determination	0.88730542
82	MP0002734_abnormal_mechanical_nocicepti	0.88641515
83	MP0001293_anophthalmia	0.88607567
84	MP0000653_abnormal_sex_gland	0.88514539
85	MP0002751_abnormal_autonomic_nervous	0.88018227
86	MP0003937_abnormal_limbs/digits/tail_de	0.87788086
87	MP0003567_abnormal_fetal_cardiomyocyte	0.86816181
88	MP0002163_abnormal_gland_morphology	0.86238024
89	MP0002234_abnormal_pharynx_morphology	0.85351440
90	MP0001764_abnormal_homeostasis	0.83890667
91	MP0002138_abnormal_hepatobiliary_system	0.83200924
92	MP0001324_abnormal_eye_pigmentation	0.80662085
93	MP0002882_abnormal_neuron_morphology	0.79774929
94	MP0001502_abnormal_circadian_rhythm	0.79745230
95	MP0002229_neurodegeneration	0.79405506
96	MP0001145_abnormal_male_reproductive	0.79323161
97	MP0001119_abnormal_female_reproductive	0.79258258
98	MP0004145_abnormal_muscle_electrophysio	0.75822650
99	MP0004742_abnormal_vestibular_system	0.74634165
100	MP0000955_abnormal_spinal_cord	0.73434990

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.40632201
2	True hermaphroditism (HP:0010459)	4.19704978
3	Hyperventilation (HP:0002883)	3.96129016
4	Pancreatic fibrosis (HP:0100732)	3.92921193
5	Molar tooth sign on MRI (HP:0002419)	3.76378827
6	Abnormality of midbrain morphology (HP:0002418)	3.76378827
7	Medial flaring of the eyebrow (HP:0010747)	3.49913772
8	Chronic hepatic failure (HP:0100626)	3.25857114
9	Nephronophthisis (HP:0000090)	3.20379071
10	Attenuation of retinal blood vessels (HP:0007843)	3.16685313
11	Progressive cerebellar ataxia (HP:0002073)	3.16569471
12	Genetic anticipation (HP:0003743)	3.16549985
13	Gait imbalance (HP:0002141)	3.07885208
14	Congenital primary aphakia (HP:0007707)	2.99320457
15	Nephrogenic diabetes insipidus (HP:0009806)	2.87895347
16	Gaze-evoked nystagmus (HP:0000640)	2.83343778
17	Abnormality of the renal medulla (HP:0100957)	2.77947755
18	Abnormality of the renal cortex (HP:0011035)	2.75108198
19	Pendular nystagmus (HP:0012043)	2.74337696
20	Congenital stationary night blindness (HP:0007642)	2.67853733
21	Broad-based gait (HP:0002136)	2.66888755
22	Type II lissencephaly (HP:0007260)	2.61664230
23	Neoplasm of the adrenal cortex (HP:0100641)	2.58824866
24	Progressive inability to walk (HP:0002505)	2.56136507
25	Genital tract atresia (HP:0001827)	2.54798389
26	Cystic liver disease (HP:0006706)	2.54494025
27	Colon cancer (HP:0003003)	2.54299499
28	Abolished electroretinogram (ERG) (HP:0000550)	2.52849895
29	Vaginal atresia (HP:0000148)	2.50806853
30	Lissencephaly (HP:0001339)	2.44866639
31	Inability to walk (HP:0002540)	2.43748523
32	Protruding tongue (HP:0010808)	2.41327615
33	Bile duct proliferation (HP:0001408)	2.41107241
34	Abnormal biliary tract physiology (HP:0012439)	2.41107241
35	Methylmalonic acidemia (HP:0002912)	2.40899634
36	Poor coordination (HP:0002370)	2.40647072
37	Febrile seizures (HP:0002373)	2.39771558
38	Abnormality of the labia minora (HP:0012880)	2.33930828
39	Fair hair (HP:0002286)	2.32325890
40	Absent speech (HP:0001344)	2.31418215
41	Intestinal atresia (HP:0011100)	2.27470024
42	Methylmalonic aciduria (HP:0012120)	2.25982322
43	Stomach cancer (HP:0012126)	2.21240173
44	Anencephaly (HP:0002323)	2.21232017
45	Tubular atrophy (HP:0000092)	2.19409335
46	Clumsiness (HP:0002312)	2.18669749
47	Optic nerve hypoplasia (HP:0000609)	2.17849363
48	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.17206986
49	Sclerocornea (HP:0000647)	2.15617591
50	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.13665892
51	Hemiparesis (HP:0001269)	2.13372676
52	Male pseudohermaphroditism (HP:0000037)	2.13092358
53	Renal cortical cysts (HP:0000803)	2.12678436
54	Postaxial foot polydactyly (HP:0001830)	2.07388382
55	Abnormal drinking behavior (HP:0030082)	2.05950049
56	Polydipsia (HP:0001959)	2.05950049
57	Postaxial hand polydactyly (HP:0001162)	2.05471030
58	Congenital hepatic fibrosis (HP:0002612)	2.04656876
59	Retinal dysplasia (HP:0007973)	2.04225788
60	Hyperglycinemia (HP:0002154)	2.01111288
61	Drooling (HP:0002307)	1.99711740
62	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.96447318
63	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.95065302
64	Astigmatism (HP:0000483)	1.95020812
65	Pachygyria (HP:0001302)	1.91593982
66	Abnormal rod and cone electroretinograms (HP:0008323)	1.91401372
67	Widely spaced teeth (HP:0000687)	1.89926192
68	Increased corneal curvature (HP:0100692)	1.89047692
69	Keratoconus (HP:0000563)	1.89047692
70	Bony spicule pigmentary retinopathy (HP:0007737)	1.88149183
71	Narrow forehead (HP:0000341)	1.86620294
72	Focal seizures (HP:0007359)	1.85974479
73	Thyroiditis (HP:0100646)	1.85478257
74	Oligodactyly (hands) (HP:0001180)	1.85083975
75	Tubulointerstitial nephritis (HP:0001970)	1.82100431
76	Abnormality of the ileum (HP:0001549)	1.81617779
77	Excessive salivation (HP:0003781)	1.81096568
78	Specific learning disability (HP:0001328)	1.79298158
79	Dyskinesia (HP:0100660)	1.79218476
80	Cupped ear (HP:0000378)	1.77279580
81	Decreased central vision (HP:0007663)	1.76543226
82	Meckel diverticulum (HP:0002245)	1.76484520
83	Furrowed tongue (HP:0000221)	1.75439511
84	Preaxial hand polydactyly (HP:0001177)	1.72840427
85	Focal motor seizures (HP:0011153)	1.72022629
86	Sloping forehead (HP:0000340)	1.71729181
87	Short foot (HP:0001773)	1.71280737
88	Dandy-Walker malformation (HP:0001305)	1.70581570
89	Ectopic kidney (HP:0000086)	1.70196161
90	Aganglionic megacolon (HP:0002251)	1.69241415
91	Volvulus (HP:0002580)	1.69021028
92	Tented upper lip vermilion (HP:0010804)	1.68790248
93	Occipital encephalocele (HP:0002085)	1.67180095
94	Small hand (HP:0200055)	1.66739013
95	Cerebellar dysplasia (HP:0007033)	1.65764839
96	Prominent nasal bridge (HP:0000426)	1.65762591
97	Abnormality of chromosome stability (HP:0003220)	1.65124778
98	Supernumerary spleens (HP:0009799)	1.62022938
99	Patellar aplasia (HP:0006443)	1.61697542
100	Hyperalaninemia (HP:0003348)	1.61429602

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.18294506
2	WNK3	3.00308917
3	CASK	2.89675259
4	BMPR1B	2.81830729
5	NUAK1	2.69381766
6	MAP3K4	2.37079036
7	ACVR1B	2.26850236
8	ADRBK2	2.21888368
9	ZAK	2.17418254
10	MARK1	2.03936344
11	MAPK13	1.96104583
12	GRK1	1.88016025
13	TNIK	1.82630369
14	MAP4K2	1.80961494
15	TRIM28	1.70949091
16	INSRR	1.68893641
17	TAOK3	1.63471905
18	MAP2K7	1.61629723
19	MKNK2	1.47979151
20	BCR	1.41655438
21	CSNK1G2	1.34998878
22	CSNK1G1	1.32051568
23	FGFR2	1.29858683
24	TLK1	1.28429085
25	PAK3	1.27483110
26	CDK19	1.27000958
27	CSNK1G3	1.26378627
28	CAMKK2	1.25824026
29	AKT3	1.25566477
30	CSNK1A1L	1.20536512
31	PINK1	1.16360630
32	DYRK2	1.15582634
33	OXSR1	1.13234162
34	PNCK	1.11559063
35	PLK2	1.01990192
36	EPHA4	0.99413073
37	STK38L	0.97925458
38	SIK2	0.96566625
39	ADRBK1	0.94565759
40	TGFBR1	0.91094203
41	CAMK1G	0.89195053
42	NTRK3	0.87797777
43	TXK	0.86341911
44	SRPK1	0.84650057
45	NTRK2	0.84609409
46	BRD4	0.82172090
47	EIF2AK3	0.81599313
48	WNK4	0.80547912
49	PRKCE	0.78235888
50	PTK2B	0.76910479
51	BCKDK	0.73473354
52	TIE1	0.72234404
53	SGK2	0.69713784
54	CAMK1D	0.68636502
55	VRK1	0.67297839
56	PRKCG	0.66152915
57	DYRK1A	0.66074822
58	DAPK2	0.66001643
59	PLK4	0.64304592
60	ERBB3	0.64258874
61	MKNK1	0.61325184
62	TEC	0.59657178
63	MAP2K4	0.59024646
64	STK39	0.58735566
65	CSNK1D	0.58722746
66	STK16	0.56263153
67	ATM	0.54650923
68	PLK3	0.53643750
69	NLK	0.52271583
70	STK3	0.52168164
71	CAMK4	0.51414744
72	PIK3CA	0.51124094
73	LATS1	0.50346648
74	RPS6KA5	0.49040838
75	ATR	0.48655382
76	OBSCN	0.48430956
77	CAMK1	0.48412817
78	TNK2	0.47673310
79	BRSK2	0.47061448
80	PKN1	0.45166118
81	PIK3CG	0.44808555
82	CSNK1A1	0.44387427
83	PLK1	0.44064147
84	DYRK3	0.43465265
85	SGK494	0.42813946
86	SGK223	0.42813946
87	CHEK2	0.42543953
88	STK11	0.41548890
89	PRKCZ	0.40351722
90	FER	0.40056423
91	CAMK2A	0.39475740
92	NEK2	0.38776947
93	CHUK	0.37175228
94	TAF1	0.37150766
95	EPHA3	0.36987803
96	PRKACA	0.36716481
97	PRKCQ	0.36567850
98	PRKAA1	0.36402545
99	IRAK1	0.34467948
100	CDK3	0.33502630

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.06919793
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.69343748
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.51528503
4	Basal transcription factors_Homo sapiens_hsa03022	2.44644449
5	Nicotine addiction_Homo sapiens_hsa05033	2.40580210
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.38539752
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.34089837
8	Butanoate metabolism_Homo sapiens_hsa00650	2.28472252
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.19570042
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.13484480
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.04154146
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.02802654
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.97744289
14	Propanoate metabolism_Homo sapiens_hsa00640	1.97032657
15	Protein export_Homo sapiens_hsa03060	1.97013858
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.95948710
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.95730238
18	RNA polymerase_Homo sapiens_hsa03020	1.87387730
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.80546881
20	Homologous recombination_Homo sapiens_hsa03440	1.80289128
21	RNA degradation_Homo sapiens_hsa03018	1.77626595
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.72194390
23	Taste transduction_Homo sapiens_hsa04742	1.70409611
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.70269303
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.60511386
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59117704
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.52973969
28	Circadian rhythm_Homo sapiens_hsa04710	1.47688866
29	Olfactory transduction_Homo sapiens_hsa04740	1.37037500
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.30833368
31	Morphine addiction_Homo sapiens_hsa05032	1.30798216
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.25153580
33	GABAergic synapse_Homo sapiens_hsa04727	1.24790597
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.17049045
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15513582
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.14663801
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.14177269
38	Regulation of autophagy_Homo sapiens_hsa04140	1.11674224
39	Caffeine metabolism_Homo sapiens_hsa00232	1.11139314
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.03591506
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.01595875
42	ABC transporters_Homo sapiens_hsa02010	0.99838319
43	Circadian entrainment_Homo sapiens_hsa04713	0.97046626
44	Glutamatergic synapse_Homo sapiens_hsa04724	0.92578917
45	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.90415544
46	Insulin secretion_Homo sapiens_hsa04911	0.89814089
47	Lysine degradation_Homo sapiens_hsa00310	0.89214119
48	Peroxisome_Homo sapiens_hsa04146	0.88351263
49	Primary immunodeficiency_Homo sapiens_hsa05340	0.86953636
50	Asthma_Homo sapiens_hsa05310	0.85055867
51	Serotonergic synapse_Homo sapiens_hsa04726	0.83649821
52	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.82463167
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.82173794
54	Type I diabetes mellitus_Homo sapiens_hsa04940	0.80256839
55	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.79896591
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.79130123
57	Dopaminergic synapse_Homo sapiens_hsa04728	0.76101517
58	RNA transport_Homo sapiens_hsa03013	0.69590427
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67863258
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65294751
61	Cocaine addiction_Homo sapiens_hsa05030	0.63847611
62	Oxidative phosphorylation_Homo sapiens_hsa00190	0.60894102
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60484777
64	Purine metabolism_Homo sapiens_hsa00230	0.57994061
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.54026672
66	Long-term depression_Homo sapiens_hsa04730	0.53126203
67	Salivary secretion_Homo sapiens_hsa04970	0.52789157
68	mRNA surveillance pathway_Homo sapiens_hsa03015	0.52172524
69	Amphetamine addiction_Homo sapiens_hsa05031	0.46493291
70	One carbon pool by folate_Homo sapiens_hsa00670	0.46483882
71	Basal cell carcinoma_Homo sapiens_hsa05217	0.46314180
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.45939662
73	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.45581156
74	Parkinsons disease_Homo sapiens_hsa05012	0.45413666
75	Allograft rejection_Homo sapiens_hsa05330	0.44150396
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43907836
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43680943
78	Nucleotide excision repair_Homo sapiens_hsa03420	0.43558793
79	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.43463433
80	Oocyte meiosis_Homo sapiens_hsa04114	0.43221031
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43194839
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42567983
83	Huntingtons disease_Homo sapiens_hsa05016	0.40694772
84	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.40648947
85	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.40549200
86	Cholinergic synapse_Homo sapiens_hsa04725	0.39742461
87	Pyrimidine metabolism_Homo sapiens_hsa00240	0.38949113
88	cAMP signaling pathway_Homo sapiens_hsa04024	0.38918991
89	Metabolic pathways_Homo sapiens_hsa01100	0.38722153
90	Graft-versus-host disease_Homo sapiens_hsa05332	0.38537325
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.38196879
92	Collecting duct acid secretion_Homo sapiens_hsa04966	0.37424164
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.36441501
94	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.35525772
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34902487
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.33899551
97	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.32466363
98	Cardiac muscle contraction_Homo sapiens_hsa04260	0.32217520
99	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.31169862
100	Fatty acid elongation_Homo sapiens_hsa00062	0.30763285

ZNF549

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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