ZNF549

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neural tube formation (GO:0001841)4.34212259
2behavioral response to nicotine (GO:0035095)4.21006313
3cell wall macromolecule metabolic process (GO:0044036)4.06740858
4fucose catabolic process (GO:0019317)3.94533296
5L-fucose metabolic process (GO:0042354)3.94533296
6L-fucose catabolic process (GO:0042355)3.94533296
7response to pheromone (GO:0019236)3.84556488
8negative regulation of mast cell activation (GO:0033004)3.71686257
9pyrimidine nucleobase catabolic process (GO:0006208)3.69019100
10cornea development in camera-type eye (GO:0061303)3.51442420
11protein K11-linked deubiquitination (GO:0035871)3.44533087
12retinal cone cell development (GO:0046549)3.32482916
13presynaptic membrane assembly (GO:0097105)3.31871847
14nonmotile primary cilium assembly (GO:0035058)3.28527312
15regulation of meiosis I (GO:0060631)3.25366360
16piRNA metabolic process (GO:0034587)3.25004242
17DNA double-strand break processing (GO:0000729)3.23175478
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.23040073
19platelet dense granule organization (GO:0060155)3.19935744
20behavioral response to ethanol (GO:0048149)3.17413803
21detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14736682
22regulation of acrosome reaction (GO:0060046)3.09016708
23detection of light stimulus involved in sensory perception (GO:0050962)3.02773964
24detection of light stimulus involved in visual perception (GO:0050908)3.02773964
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.01770289
26regulation of translation, ncRNA-mediated (GO:0045974)3.01770289
27negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.01770289
28gamma-aminobutyric acid transport (GO:0015812)3.01752349
29cilium or flagellum-dependent cell motility (GO:0001539)3.01265799
30nucleobase catabolic process (GO:0046113)2.99958382
31cilium morphogenesis (GO:0060271)2.96219378
32negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92749049
33RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.91609567
34indolalkylamine metabolic process (GO:0006586)2.88800178
35ubiquinone biosynthetic process (GO:0006744)2.87673882
36epithelial cilium movement (GO:0003351)2.85271634
37ubiquinone metabolic process (GO:0006743)2.84289159
38presynaptic membrane organization (GO:0097090)2.83617314
39water-soluble vitamin biosynthetic process (GO:0042364)2.82440598
40photoreceptor cell maintenance (GO:0045494)2.82078233
41multicellular organism reproduction (GO:0032504)2.80826918
42negative regulation of DNA-dependent DNA replication (GO:2000104)2.79349687
43regulation of nuclear cell cycle DNA replication (GO:0033262)2.74011687
44establishment of protein localization to Golgi (GO:0072600)2.73935737
45limb bud formation (GO:0060174)2.73825049
46regulation of female gonad development (GO:2000194)2.73374322
47DNA deamination (GO:0045006)2.70496316
48cilium organization (GO:0044782)2.70294115
49regulation of action potential (GO:0098900)2.67625377
50photoreceptor cell development (GO:0042461)2.67607338
51DNA methylation involved in gamete generation (GO:0043046)2.66110704
52tryptophan catabolic process (GO:0006569)2.65191393
53indole-containing compound catabolic process (GO:0042436)2.65191393
54indolalkylamine catabolic process (GO:0046218)2.65191393
55replication fork processing (GO:0031297)2.63170886
56negative regulation of synaptic transmission, GABAergic (GO:0032229)2.62805029
57axoneme assembly (GO:0035082)2.61161359
58cilium assembly (GO:0042384)2.60396655
59recombinational repair (GO:0000725)2.59314487
60sulfation (GO:0051923)2.58835790
61intraciliary transport (GO:0042073)2.58545009
62preassembly of GPI anchor in ER membrane (GO:0016254)2.58453886
63embryonic epithelial tube formation (GO:0001838)2.58236756
64histone H3-K9 methylation (GO:0051567)2.57439385
65kynurenine metabolic process (GO:0070189)2.55086341
66prenylation (GO:0097354)2.54642584
67protein prenylation (GO:0018342)2.54642584
68head development (GO:0060322)2.54314020
69double-strand break repair via homologous recombination (GO:0000724)2.54214652
70cilium movement (GO:0003341)2.53748716
71DNA demethylation (GO:0080111)2.53600125
72regulation of telomere maintenance (GO:0032204)2.50597293
73positive regulation of oligodendrocyte differentiation (GO:0048714)2.48816920
74DNA integration (GO:0015074)2.48548182
75somite development (GO:0061053)2.48008476
76reciprocal DNA recombination (GO:0035825)2.47349098
77reciprocal meiotic recombination (GO:0007131)2.47349098
78monoubiquitinated protein deubiquitination (GO:0035520)2.46404645
79microtubule anchoring (GO:0034453)2.46176975
80eye photoreceptor cell development (GO:0042462)2.45281253
81protein localization to cilium (GO:0061512)2.45244461
82anterograde synaptic vesicle transport (GO:0048490)2.45053549
83negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.44319235
84positive regulation of developmental pigmentation (GO:0048087)2.44195996
85neuron cell-cell adhesion (GO:0007158)2.44148130
86pyrimidine dimer repair (GO:0006290)2.43178922
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.41955567
88peptidyl-histidine modification (GO:0018202)2.41654001
89epithelial tube formation (GO:0072175)2.41605720
90centriole replication (GO:0007099)2.41554947
91inositol phosphate catabolic process (GO:0071545)2.41243621
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40467218
93kidney morphogenesis (GO:0060993)2.39450066
94neuronal action potential (GO:0019228)2.38730252
95male meiosis I (GO:0007141)2.38473792
96oxidative demethylation (GO:0070989)2.37802975
97rRNA catabolic process (GO:0016075)2.37758841
98central nervous system neuron axonogenesis (GO:0021955)2.35924820
99tryptophan metabolic process (GO:0006568)2.35138654
100olfactory bulb development (GO:0021772)2.34131359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela4.13745990
2EZH2_22144423_ChIP-Seq_EOC_Human3.37804553
3GBX2_23144817_ChIP-Seq_PC3_Human3.08245365
4IGF1R_20145208_ChIP-Seq_DFB_Human2.95375453
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.93570271
6VDR_22108803_ChIP-Seq_LS180_Human2.93486125
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69135797
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67627895
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54472324
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50920888
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.29516692
12EWS_26573619_Chip-Seq_HEK293_Human2.29231348
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19923611
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19236140
15P300_19829295_ChIP-Seq_ESCs_Human2.13391080
16FUS_26573619_Chip-Seq_HEK293_Human2.11272574
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08708920
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.07738798
19TAF15_26573619_Chip-Seq_HEK293_Human2.05317061
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95716076
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84335128
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84209214
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82908821
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82108409
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81265830
26ER_23166858_ChIP-Seq_MCF-7_Human1.75401884
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73543424
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70006378
29CBP_20019798_ChIP-Seq_JUKART_Human1.69277103
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69277103
31STAT3_23295773_ChIP-Seq_U87_Human1.68101725
32SMAD4_21799915_ChIP-Seq_A2780_Human1.63328329
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61880654
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61448865
35IRF1_19129219_ChIP-ChIP_H3396_Human1.56954259
36TCF4_23295773_ChIP-Seq_U87_Human1.56505085
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54157126
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54157126
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.52256148
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51553134
41BCAT_22108803_ChIP-Seq_LS180_Human1.50844750
42AR_25329375_ChIP-Seq_VCAP_Human1.47781595
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46424311
44TP53_22573176_ChIP-Seq_HFKS_Human1.46055919
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45646156
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45207528
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44617854
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39782233
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37783988
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37494906
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.35904054
52RUNX2_22187159_ChIP-Seq_PCA_Human1.34648162
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33354702
54PRDM14_20953172_ChIP-Seq_ESCs_Human1.32398161
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30402151
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27859368
57* EST1_17652178_ChIP-ChIP_JURKAT_Human1.26837809
58REST_21632747_ChIP-Seq_MESCs_Mouse1.26268894
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23846095
60TCF4_22108803_ChIP-Seq_LS180_Human1.23478719
61NANOG_19829295_ChIP-Seq_ESCs_Human1.23469429
62SOX2_19829295_ChIP-Seq_ESCs_Human1.23469429
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.23442639
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.23091250
65* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22682235
66ELK1_19687146_ChIP-ChIP_HELA_Human1.22208024
67AR_21572438_ChIP-Seq_LNCaP_Human1.21127530
68MYC_18940864_ChIP-ChIP_HL60_Human1.20266619
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.20170052
70* GABP_17652178_ChIP-ChIP_JURKAT_Human1.20052933
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17989938
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.17035168
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15399733
74VDR_23849224_ChIP-Seq_CD4+_Human1.14140642
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.13809949
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13319402
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.11789817
78RNF2_27304074_Chip-Seq_NSC_Mouse1.10909208
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.09811940
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08580475
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06622439
82KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06610157
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04227144
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.03556107
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03556107
86AR_20517297_ChIP-Seq_VCAP_Human1.01366660
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.00999717
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00994613
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00731269
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00679274
91NCOR_22424771_ChIP-Seq_293T_Human0.99877752
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.98441260
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98427864
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97840606
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96067021
96TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95809886
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95482579
98P53_22387025_ChIP-Seq_ESCs_Mouse0.95322610
99KDM2B_26808549_Chip-Seq_REH_Human0.94638571
100CDX2_22108803_ChIP-Seq_LS180_Human0.94127402

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.30482849
2MP0000569_abnormal_digit_pigmentation3.48705077
3MP0002102_abnormal_ear_morphology3.10490128
4MP0003787_abnormal_imprinting2.84938139
5MP0001968_abnormal_touch/_nociception2.30696778
6MP0005551_abnormal_eye_electrophysiolog2.29265915
7MP0008057_abnormal_DNA_replication2.25741392
8MP0003880_abnormal_central_pattern2.18143691
9MP0002736_abnormal_nociception_after2.10874789
10MP0003195_calcinosis2.10544499
11MP0005646_abnormal_pituitary_gland2.03142285
12MP0009046_muscle_twitch2.01080798
13MP0006292_abnormal_olfactory_placode1.97749804
14MP0006072_abnormal_retinal_apoptosis1.91961657
15MP0002638_abnormal_pupillary_reflex1.87574634
16MP0001986_abnormal_taste_sensitivity1.75140922
17MP0002653_abnormal_ependyma_morphology1.74652798
18MP0009745_abnormal_behavioral_response1.74209998
19MP0006276_abnormal_autonomic_nervous1.71906877
20MP0008058_abnormal_DNA_repair1.69002935
21MP0005253_abnormal_eye_physiology1.67883898
22MP0002735_abnormal_chemical_nociception1.64197780
23MP0003136_yellow_coat_color1.62934210
24MP0003718_maternal_effect1.59884439
25MP0005174_abnormal_tail_pigmentation1.59830839
26MP0002822_catalepsy1.58946695
27MP0004043_abnormal_pH_regulation1.58666446
28MP0003121_genomic_imprinting1.57914898
29MP0005645_abnormal_hypothalamus_physiol1.55074248
30MP0005367_renal/urinary_system_phenotyp1.50941531
31MP0000516_abnormal_urinary_system1.50941531
32MP0000427_abnormal_hair_cycle1.50626185
33MP0000631_abnormal_neuroendocrine_gland1.48311055
34MP0001486_abnormal_startle_reflex1.47354262
35MP0002272_abnormal_nervous_system1.47191510
36MP0004142_abnormal_muscle_tone1.47025176
37MP0003646_muscle_fatigue1.46984552
38MP0001984_abnormal_olfaction1.44875572
39MP0005386_behavior/neurological_phenoty1.40813066
40MP0004924_abnormal_behavior1.40813066
41MP0000778_abnormal_nervous_system1.36824834
42MP0003890_abnormal_embryonic-extraembry1.34900520
43MP0008872_abnormal_physiological_respon1.32273050
44MP0005423_abnormal_somatic_nervous1.32047726
45MP0004133_heterotaxia1.30063323
46MP0008789_abnormal_olfactory_epithelium1.29423984
47MP0002572_abnormal_emotion/affect_behav1.29219846
48MP0002837_dystrophic_cardiac_calcinosis1.28206385
49MP0001501_abnormal_sleep_pattern1.27883430
50MP0004885_abnormal_endolymph1.25372426
51MP0008995_early_reproductive_senescence1.24330423
52MP0005187_abnormal_penis_morphology1.22454898
53MP0002928_abnormal_bile_duct1.22350416
54MP0002064_seizures1.20470351
55MP0002095_abnormal_skin_pigmentation1.20100633
56MP0003119_abnormal_digestive_system1.19791220
57MP0005075_abnormal_melanosome_morpholog1.19740027
58MP0002067_abnormal_sensory_capabilities1.17681627
59MP0002557_abnormal_social/conspecific_i1.17122374
60MP0001529_abnormal_vocalization1.16529087
61MP0002938_white_spotting1.16336500
62MP0003635_abnormal_synaptic_transmissio1.16197226
63MP0005394_taste/olfaction_phenotype1.15588724
64MP0005499_abnormal_olfactory_system1.15588724
65MP0004147_increased_porphyrin_level1.10313231
66MP0000383_abnormal_hair_follicle1.09370073
67MP0001919_abnormal_reproductive_system1.09302581
68MP0002063_abnormal_learning/memory/cond1.07873178
69MP0001929_abnormal_gametogenesis1.04914761
70MP0005389_reproductive_system_phenotype1.03936634
71MP0005195_abnormal_posterior_eye1.02694014
72MP0001970_abnormal_pain_threshold1.00500161
73MP0002160_abnormal_reproductive_system1.00143806
74MP0000372_irregular_coat_pigmentation1.00095632
75MP0001188_hyperpigmentation0.99477838
76MP0003698_abnormal_male_reproductive0.98073083
77MP0002733_abnormal_thermal_nociception0.96296527
78MP0000647_abnormal_sebaceous_gland0.93198701
79MP0002752_abnormal_somatic_nervous0.90718460
80MP0001485_abnormal_pinna_reflex0.89026754
81MP0002210_abnormal_sex_determination0.88730542
82MP0002734_abnormal_mechanical_nocicepti0.88641515
83MP0001293_anophthalmia0.88607567
84MP0000653_abnormal_sex_gland0.88514539
85MP0002751_abnormal_autonomic_nervous0.88018227
86MP0003937_abnormal_limbs/digits/tail_de0.87788086
87MP0003567_abnormal_fetal_cardiomyocyte0.86816181
88MP0002163_abnormal_gland_morphology0.86238024
89MP0002234_abnormal_pharynx_morphology0.85351440
90MP0001764_abnormal_homeostasis0.83890667
91MP0002138_abnormal_hepatobiliary_system0.83200924
92MP0001324_abnormal_eye_pigmentation0.80662085
93MP0002882_abnormal_neuron_morphology0.79774929
94MP0001502_abnormal_circadian_rhythm0.79745230
95MP0002229_neurodegeneration0.79405506
96MP0001145_abnormal_male_reproductive0.79323161
97MP0001119_abnormal_female_reproductive0.79258258
98MP0004145_abnormal_muscle_electrophysio0.75822650
99MP0004742_abnormal_vestibular_system0.74634165
100MP0000955_abnormal_spinal_cord0.73434990

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.40632201
2True hermaphroditism (HP:0010459)4.19704978
3Hyperventilation (HP:0002883)3.96129016
4Pancreatic fibrosis (HP:0100732)3.92921193
5Molar tooth sign on MRI (HP:0002419)3.76378827
6Abnormality of midbrain morphology (HP:0002418)3.76378827
7Medial flaring of the eyebrow (HP:0010747)3.49913772
8Chronic hepatic failure (HP:0100626)3.25857114
9Nephronophthisis (HP:0000090)3.20379071
10Attenuation of retinal blood vessels (HP:0007843)3.16685313
11Progressive cerebellar ataxia (HP:0002073)3.16569471
12Genetic anticipation (HP:0003743)3.16549985
13Gait imbalance (HP:0002141)3.07885208
14Congenital primary aphakia (HP:0007707)2.99320457
15Nephrogenic diabetes insipidus (HP:0009806)2.87895347
16Gaze-evoked nystagmus (HP:0000640)2.83343778
17Abnormality of the renal medulla (HP:0100957)2.77947755
18Abnormality of the renal cortex (HP:0011035)2.75108198
19Pendular nystagmus (HP:0012043)2.74337696
20Congenital stationary night blindness (HP:0007642)2.67853733
21Broad-based gait (HP:0002136)2.66888755
22Type II lissencephaly (HP:0007260)2.61664230
23Neoplasm of the adrenal cortex (HP:0100641)2.58824866
24Progressive inability to walk (HP:0002505)2.56136507
25Genital tract atresia (HP:0001827)2.54798389
26Cystic liver disease (HP:0006706)2.54494025
27Colon cancer (HP:0003003)2.54299499
28Abolished electroretinogram (ERG) (HP:0000550)2.52849895
29Vaginal atresia (HP:0000148)2.50806853
30Lissencephaly (HP:0001339)2.44866639
31Inability to walk (HP:0002540)2.43748523
32Protruding tongue (HP:0010808)2.41327615
33Abnormal biliary tract physiology (HP:0012439)2.41107241
34Bile duct proliferation (HP:0001408)2.41107241
35Methylmalonic acidemia (HP:0002912)2.40899634
36Poor coordination (HP:0002370)2.40647072
37Febrile seizures (HP:0002373)2.39771558
38Abnormality of the labia minora (HP:0012880)2.33930828
39Fair hair (HP:0002286)2.32325890
40Absent speech (HP:0001344)2.31418215
41Intestinal atresia (HP:0011100)2.27470024
42Methylmalonic aciduria (HP:0012120)2.25982322
43Stomach cancer (HP:0012126)2.21240173
44Anencephaly (HP:0002323)2.21232017
45Tubular atrophy (HP:0000092)2.19409335
46Clumsiness (HP:0002312)2.18669749
47Optic nerve hypoplasia (HP:0000609)2.17849363
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.17206986
49Sclerocornea (HP:0000647)2.15617591
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.13665892
51Hemiparesis (HP:0001269)2.13372676
52Male pseudohermaphroditism (HP:0000037)2.13092358
53Renal cortical cysts (HP:0000803)2.12678436
54Postaxial foot polydactyly (HP:0001830)2.07388382
55Abnormal drinking behavior (HP:0030082)2.05950049
56Polydipsia (HP:0001959)2.05950049
57Postaxial hand polydactyly (HP:0001162)2.05471030
58Congenital hepatic fibrosis (HP:0002612)2.04656876
59Retinal dysplasia (HP:0007973)2.04225788
60Hyperglycinemia (HP:0002154)2.01111288
61Drooling (HP:0002307)1.99711740
62Aplasia/Hypoplasia of the uvula (HP:0010293)1.96447318
63Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95065302
64Astigmatism (HP:0000483)1.95020812
65Pachygyria (HP:0001302)1.91593982
66Abnormal rod and cone electroretinograms (HP:0008323)1.91401372
67Widely spaced teeth (HP:0000687)1.89926192
68Increased corneal curvature (HP:0100692)1.89047692
69Keratoconus (HP:0000563)1.89047692
70Bony spicule pigmentary retinopathy (HP:0007737)1.88149183
71Narrow forehead (HP:0000341)1.86620294
72Focal seizures (HP:0007359)1.85974479
73Thyroiditis (HP:0100646)1.85478257
74Oligodactyly (hands) (HP:0001180)1.85083975
75Tubulointerstitial nephritis (HP:0001970)1.82100431
76Abnormality of the ileum (HP:0001549)1.81617779
77Excessive salivation (HP:0003781)1.81096568
78Specific learning disability (HP:0001328)1.79298158
79Dyskinesia (HP:0100660)1.79218476
80Cupped ear (HP:0000378)1.77279580
81Decreased central vision (HP:0007663)1.76543226
82Meckel diverticulum (HP:0002245)1.76484520
83Furrowed tongue (HP:0000221)1.75439511
84Preaxial hand polydactyly (HP:0001177)1.72840427
85Focal motor seizures (HP:0011153)1.72022629
86Sloping forehead (HP:0000340)1.71729181
87Short foot (HP:0001773)1.71280737
88Dandy-Walker malformation (HP:0001305)1.70581570
89Ectopic kidney (HP:0000086)1.70196161
90Aganglionic megacolon (HP:0002251)1.69241415
91Volvulus (HP:0002580)1.69021028
92Tented upper lip vermilion (HP:0010804)1.68790248
93Occipital encephalocele (HP:0002085)1.67180095
94Small hand (HP:0200055)1.66739013
95Cerebellar dysplasia (HP:0007033)1.65764839
96Prominent nasal bridge (HP:0000426)1.65762591
97Abnormality of chromosome stability (HP:0003220)1.65124778
98Supernumerary spleens (HP:0009799)1.62022938
99Patellar aplasia (HP:0006443)1.61697542
100Hyperalaninemia (HP:0003348)1.61429602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.18294506
2WNK33.00308917
3CASK2.89675259
4BMPR1B2.81830729
5NUAK12.69381766
6MAP3K42.37079036
7ACVR1B2.26850236
8ADRBK22.21888368
9ZAK2.17418254
10MARK12.03936344
11MAPK131.96104583
12GRK11.88016025
13TNIK1.82630369
14MAP4K21.80961494
15TRIM281.70949091
16INSRR1.68893641
17TAOK31.63471905
18MAP2K71.61629723
19MKNK21.47979151
20BCR1.41655438
21CSNK1G21.34998878
22CSNK1G11.32051568
23FGFR21.29858683
24TLK11.28429085
25PAK31.27483110
26CDK191.27000958
27CSNK1G31.26378627
28CAMKK21.25824026
29AKT31.25566477
30CSNK1A1L1.20536512
31PINK11.16360630
32DYRK21.15582634
33OXSR11.13234162
34PNCK1.11559063
35PLK21.01990192
36EPHA40.99413073
37STK38L0.97925458
38SIK20.96566625
39ADRBK10.94565759
40TGFBR10.91094203
41CAMK1G0.89195053
42NTRK30.87797777
43TXK0.86341911
44SRPK10.84650057
45NTRK20.84609409
46BRD40.82172090
47EIF2AK30.81599313
48WNK40.80547912
49PRKCE0.78235888
50PTK2B0.76910479
51BCKDK0.73473354
52TIE10.72234404
53SGK20.69713784
54CAMK1D0.68636502
55VRK10.67297839
56PRKCG0.66152915
57DYRK1A0.66074822
58DAPK20.66001643
59PLK40.64304592
60ERBB30.64258874
61MKNK10.61325184
62TEC0.59657178
63MAP2K40.59024646
64STK390.58735566
65CSNK1D0.58722746
66STK160.56263153
67ATM0.54650923
68PLK30.53643750
69NLK0.52271583
70STK30.52168164
71CAMK40.51414744
72PIK3CA0.51124094
73LATS10.50346648
74RPS6KA50.49040838
75ATR0.48655382
76OBSCN0.48430956
77CAMK10.48412817
78TNK20.47673310
79BRSK20.47061448
80PKN10.45166118
81PIK3CG0.44808555
82CSNK1A10.44387427
83PLK10.44064147
84DYRK30.43465265
85SGK2230.42813946
86SGK4940.42813946
87CHEK20.42543953
88STK110.41548890
89PRKCZ0.40351722
90FER0.40056423
91CAMK2A0.39475740
92NEK20.38776947
93CHUK0.37175228
94TAF10.37150766
95EPHA30.36987803
96PRKACA0.36716481
97PRKCQ0.36567850
98PRKAA10.36402545
99IRAK10.34467948
100CDK30.33502630

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.06919793
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.69343748
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51528503
4Basal transcription factors_Homo sapiens_hsa030222.44644449
5Nicotine addiction_Homo sapiens_hsa050332.40580210
6Fanconi anemia pathway_Homo sapiens_hsa034602.38539752
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34089837
8Butanoate metabolism_Homo sapiens_hsa006502.28472252
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.19570042
10Selenocompound metabolism_Homo sapiens_hsa004502.13484480
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04154146
12Linoleic acid metabolism_Homo sapiens_hsa005912.02802654
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97744289
14Propanoate metabolism_Homo sapiens_hsa006401.97032657
15Protein export_Homo sapiens_hsa030601.97013858
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95948710
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95730238
18RNA polymerase_Homo sapiens_hsa030201.87387730
19Nitrogen metabolism_Homo sapiens_hsa009101.80546881
20Homologous recombination_Homo sapiens_hsa034401.80289128
21RNA degradation_Homo sapiens_hsa030181.77626595
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.72194390
23Taste transduction_Homo sapiens_hsa047421.70409611
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70269303
25Non-homologous end-joining_Homo sapiens_hsa034501.60511386
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59117704
27Ether lipid metabolism_Homo sapiens_hsa005651.52973969
28Circadian rhythm_Homo sapiens_hsa047101.47688866
29Olfactory transduction_Homo sapiens_hsa047401.37037500
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.30833368
31Morphine addiction_Homo sapiens_hsa050321.30798216
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25153580
33GABAergic synapse_Homo sapiens_hsa047271.24790597
34Steroid biosynthesis_Homo sapiens_hsa001001.17049045
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.15513582
36Tryptophan metabolism_Homo sapiens_hsa003801.14663801
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.14177269
38Regulation of autophagy_Homo sapiens_hsa041401.11674224
39Caffeine metabolism_Homo sapiens_hsa002321.11139314
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03591506
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01595875
42ABC transporters_Homo sapiens_hsa020100.99838319
43Circadian entrainment_Homo sapiens_hsa047130.97046626
44Glutamatergic synapse_Homo sapiens_hsa047240.92578917
45Ovarian steroidogenesis_Homo sapiens_hsa049130.90415544
46Insulin secretion_Homo sapiens_hsa049110.89814089
47Lysine degradation_Homo sapiens_hsa003100.89214119
48Peroxisome_Homo sapiens_hsa041460.88351263
49Primary immunodeficiency_Homo sapiens_hsa053400.86953636
50Asthma_Homo sapiens_hsa053100.85055867
51Serotonergic synapse_Homo sapiens_hsa047260.83649821
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82463167
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82173794
54Type I diabetes mellitus_Homo sapiens_hsa049400.80256839
55Dorso-ventral axis formation_Homo sapiens_hsa043200.79896591
56Hedgehog signaling pathway_Homo sapiens_hsa043400.79130123
57Dopaminergic synapse_Homo sapiens_hsa047280.76101517
58RNA transport_Homo sapiens_hsa030130.69590427
59Glycerolipid metabolism_Homo sapiens_hsa005610.67863258
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.65294751
61Cocaine addiction_Homo sapiens_hsa050300.63847611
62Oxidative phosphorylation_Homo sapiens_hsa001900.60894102
63beta-Alanine metabolism_Homo sapiens_hsa004100.60484777
64Purine metabolism_Homo sapiens_hsa002300.57994061
65Calcium signaling pathway_Homo sapiens_hsa040200.54026672
66Long-term depression_Homo sapiens_hsa047300.53126203
67Salivary secretion_Homo sapiens_hsa049700.52789157
68mRNA surveillance pathway_Homo sapiens_hsa030150.52172524
69Amphetamine addiction_Homo sapiens_hsa050310.46493291
70One carbon pool by folate_Homo sapiens_hsa006700.46483882
71Basal cell carcinoma_Homo sapiens_hsa052170.46314180
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45939662
73Autoimmune thyroid disease_Homo sapiens_hsa053200.45581156
74Parkinsons disease_Homo sapiens_hsa050120.45413666
75Allograft rejection_Homo sapiens_hsa053300.44150396
76Chemical carcinogenesis_Homo sapiens_hsa052040.43907836
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43680943
78Nucleotide excision repair_Homo sapiens_hsa034200.43558793
79TGF-beta signaling pathway_Homo sapiens_hsa043500.43463433
80Oocyte meiosis_Homo sapiens_hsa041140.43221031
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43194839
82Arachidonic acid metabolism_Homo sapiens_hsa005900.42567983
83Huntingtons disease_Homo sapiens_hsa050160.40694772
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40648947
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40549200
86Cholinergic synapse_Homo sapiens_hsa047250.39742461
87Pyrimidine metabolism_Homo sapiens_hsa002400.38949113
88cAMP signaling pathway_Homo sapiens_hsa040240.38918991
89Metabolic pathways_Homo sapiens_hsa011000.38722153
90Graft-versus-host disease_Homo sapiens_hsa053320.38537325
91Oxytocin signaling pathway_Homo sapiens_hsa049210.38196879
92Collecting duct acid secretion_Homo sapiens_hsa049660.37424164
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36441501
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35525772
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.34902487
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33899551
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32466363
98Cardiac muscle contraction_Homo sapiens_hsa042600.32217520
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31169862
100Fatty acid elongation_Homo sapiens_hsa000620.30763285

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