ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neural tube formation (GO:0001841)	4.29980893
2	DNA double-strand break processing (GO:0000729)	3.89234211
3	preassembly of GPI anchor in ER membrane (GO:0016254)	3.82359514
4	histone H3-K9 methylation (GO:0051567)	3.79826023
5	fucose catabolic process (GO:0019317)	3.72782416
6	L-fucose metabolic process (GO:0042354)	3.72782416
7	L-fucose catabolic process (GO:0042355)	3.72782416
8	piRNA metabolic process (GO:0034587)	3.72556151
9	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.70049583
10	regulation of telomere maintenance (GO:0032204)	3.56166474
11	behavioral response to nicotine (GO:0035095)	3.55634206
12	intra-S DNA damage checkpoint (GO:0031573)	3.50249972
13	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.46295855
14	multicellular organism reproduction (GO:0032504)	3.36815549
15	protein-cofactor linkage (GO:0018065)	3.32425951
16	DNA integration (GO:0015074)	3.29928866
17	protein K11-linked deubiquitination (GO:0035871)	3.20655328
18	regulation of action potential (GO:0098900)	3.17978944
19	cytoplasmic mRNA processing body assembly (GO:0033962)	3.17672925
20	histone H3-K9 modification (GO:0061647)	3.17344348
21	positive regulation of action potential (GO:0045760)	3.17174851
22	peptidyl-histidine modification (GO:0018202)	3.15622933
23	negative regulation of telomere maintenance (GO:0032205)	3.08698162
24	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.07851046
25	regulation of mitotic spindle checkpoint (GO:1903504)	3.07851046
26	adaptation of signaling pathway (GO:0023058)	3.07472746
27	regulation of DNA endoreduplication (GO:0032875)	3.03933199
28	pyrimidine dimer repair (GO:0006290)	3.02668082
29	histone H3-K4 trimethylation (GO:0080182)	3.01576255
30	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.99779108
31	somite development (GO:0061053)	2.97791450
32	rRNA catabolic process (GO:0016075)	2.95389945
33	L-methionine salvage (GO:0071267)	2.92268572
34	L-methionine biosynthetic process (GO:0071265)	2.92268572
35	amino acid salvage (GO:0043102)	2.92268572
36	mannosylation (GO:0097502)	2.88749100
37	DNA methylation involved in gamete generation (GO:0043046)	2.85863362
38	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.85623065
39	response to pheromone (GO:0019236)	2.84389600
40	kynurenine metabolic process (GO:0070189)	2.82626251
41	activated T cell proliferation (GO:0050798)	2.81590415
42	peptidyl-lysine trimethylation (GO:0018023)	2.81483406
43	head development (GO:0060322)	2.79557085
44	GPI anchor metabolic process (GO:0006505)	2.79316980
45	replication fork processing (GO:0031297)	2.78417840
46	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.77993298
47	cilium morphogenesis (GO:0060271)	2.77673537
48	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.76993157
49	regulation of translation, ncRNA-mediated (GO:0045974)	2.76993157
50	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.76993157
51	S-adenosylmethionine metabolic process (GO:0046500)	2.75192193
52	reciprocal DNA recombination (GO:0035825)	2.74356682
53	reciprocal meiotic recombination (GO:0007131)	2.74356682
54	otic vesicle formation (GO:0030916)	2.71146300
55	somite rostral/caudal axis specification (GO:0032525)	2.69878411
56	protein K63-linked deubiquitination (GO:0070536)	2.68341962
57	pyrimidine nucleobase catabolic process (GO:0006208)	2.68104704
58	negative regulation of DNA recombination (GO:0045910)	2.67658847
59	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.67158621
60	intraciliary transport (GO:0042073)	2.67122400
61	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.66900848
62	centriole replication (GO:0007099)	2.66826501
63	ubiquinone biosynthetic process (GO:0006744)	2.65310894
64	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.65116718
65	behavioral response to ethanol (GO:0048149)	2.63868085
66	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.63358821
67	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.63358821
68	regulation of establishment of cell polarity (GO:2000114)	2.63275149
69	ubiquinone metabolic process (GO:0006743)	2.62782775
70	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.62622511
71	cilium or flagellum-dependent cell motility (GO:0001539)	2.61459826
72	dentate gyrus development (GO:0021542)	2.59162994
73	termination of RNA polymerase I transcription (GO:0006363)	2.58939135
74	synapsis (GO:0007129)	2.58672975
75	methionine biosynthetic process (GO:0009086)	2.56938198
76	negative regulation of multicellular organism growth (GO:0040015)	2.56774953
77	regulation of cilium movement (GO:0003352)	2.54671102
78	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.53352518
79	regulation of memory T cell differentiation (GO:0043380)	2.51147532
80	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.48203804
81	regulation of helicase activity (GO:0051095)	2.48186054
82	male meiosis (GO:0007140)	2.47154686
83	histone H2A acetylation (GO:0043968)	2.46962402
84	positive regulation of mitochondrial fission (GO:0090141)	2.45438400
85	epithelial cilium movement (GO:0003351)	2.44760075
86	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.44188192
87	mRNA cleavage (GO:0006379)	2.43129856
88	regulation of centriole replication (GO:0046599)	2.42997205
89	double-strand break repair via homologous recombination (GO:0000724)	2.41444364
90	recombinational repair (GO:0000725)	2.41345085
91	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.41120559
92	regulation of meiosis I (GO:0060631)	2.38872711
93	reflex (GO:0060004)	2.38474426
94	GPI anchor biosynthetic process (GO:0006506)	2.36372443
95	detection of light stimulus involved in sensory perception (GO:0050962)	2.35047148
96	detection of light stimulus involved in visual perception (GO:0050908)	2.35047148
97	somatic diversification of immune receptors (GO:0002200)	2.35005601
98	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.34844737
99	seminiferous tubule development (GO:0072520)	2.33839746
100	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.33566521

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.96527409
2	VDR_22108803_ChIP-Seq_LS180_Human	3.87189780
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.25483336
4	FUS_26573619_Chip-Seq_HEK293_Human	3.05136441
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.01978837
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.93095931
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.89885568
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.86675553
9	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.81473499
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.64357184
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.62917166
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.54651864
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.54435981
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.42981646
15	EWS_26573619_Chip-Seq_HEK293_Human	2.39646134
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.07481253
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.07180426
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.04925655
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.99092731
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.97854310
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.94207004
22	P300_19829295_ChIP-Seq_ESCs_Human	1.93587792
23	* EST1_17652178_ChIP-ChIP_JURKAT_Human	1.90305718
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.86163642
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.85770302
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.81028149
27	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.78148336
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74013407
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.68799918
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.67932945
31	EZH2_22144423_ChIP-Seq_EOC_Human	1.66208354
32	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64244242
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.62503641
34	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.60054298
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.57350910
36	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.53060514
37	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.51648610
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.50354541
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50354541
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50025326
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.45401788
42	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.44689050
43	AR_21572438_ChIP-Seq_LNCaP_Human	1.42955584
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40890772
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.39531973
46	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.39369446
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.33344729
48	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.32512777
49	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30288157
50	* ETS1_20019798_ChIP-Seq_JURKAT_Human	1.29096934
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28842316
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.28035720
53	STAT3_23295773_ChIP-Seq_U87_Human	1.27835570
54	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.26473670
55	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.25594049
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23043637
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.22475410
58	AR_25329375_ChIP-Seq_VCAP_Human	1.22077588
59	TCF4_23295773_ChIP-Seq_U87_Human	1.21891892
60	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21287661
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20242073
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.18997052
63	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18546369
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17607665
65	TCF4_22108803_ChIP-Seq_LS180_Human	1.13217767
66	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11462263
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11386176
68	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.11386176
69	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11370100
70	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.11348909
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.10360354
72	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.09819651
73	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08481289
74	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.07505904
75	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.06833298
76	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05751791
77	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.04643375
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03765597
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03707011
80	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.03505666
81	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.02191179
82	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01867444
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.01154878
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.00954708
85	CIITA_25753668_ChIP-Seq_RAJI_Human	0.98329400
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97264233
87	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97264233
88	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97023312
89	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.96589171
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.94776760
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94174445
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92319277
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92291991
94	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91233110
95	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91233110
96	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.90768772
97	HOXB7_26014856_ChIP-Seq_BT474_Human	0.89651719
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.89452389
99	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.89080803
100	NCOR_22424771_ChIP-Seq_293T_Human	0.87939979

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.76624673
2	MP0002102_abnormal_ear_morphology	3.97516895
3	MP0003787_abnormal_imprinting	3.86447868
4	MP0006072_abnormal_retinal_apoptosis	3.18115751
5	MP0001968_abnormal_touch/_nociception	2.49188200
6	MP0002736_abnormal_nociception_after	2.43248701
7	MP0006292_abnormal_olfactory_placode	2.42803207
8	MP0003880_abnormal_central_pattern	2.39238061
9	MP0008058_abnormal_DNA_repair	2.26190566
10	MP0003136_yellow_coat_color	2.18758189
11	MP0002009_preneoplasia	2.16941122
12	MP0005075_abnormal_melanosome_morpholog	2.14853366
13	MP0000569_abnormal_digit_pigmentation	2.12994962
14	MP0005253_abnormal_eye_physiology	2.00529540
15	MP0008057_abnormal_DNA_replication	1.99555992
16	MP0002638_abnormal_pupillary_reflex	1.93727224
17	MP0000372_irregular_coat_pigmentation	1.92884495
18	MP0002837_dystrophic_cardiac_calcinosis	1.89214093
19	MP0003121_genomic_imprinting	1.84113947
20	MP0001529_abnormal_vocalization	1.78227733
21	MP0001986_abnormal_taste_sensitivity	1.73637034
22	MP0001984_abnormal_olfaction	1.71916864
23	MP0003122_maternal_imprinting	1.71566099
24	MP0005646_abnormal_pituitary_gland	1.58813655
25	MP0005551_abnormal_eye_electrophysiolog	1.55057499
26	MP0002751_abnormal_autonomic_nervous	1.53925779
27	MP0001188_hyperpigmentation	1.52804989
28	MP0000516_abnormal_urinary_system	1.44900127
29	MP0005367_renal/urinary_system_phenotyp	1.44900127
30	MP0002735_abnormal_chemical_nociception	1.44150996
31	MP0000631_abnormal_neuroendocrine_gland	1.42408411
32	MP0008995_early_reproductive_senescence	1.35553251
33	MP0003646_muscle_fatigue	1.29479109
34	MP0004133_heterotaxia	1.29401647
35	MP0006276_abnormal_autonomic_nervous	1.25297019
36	MP0010094_abnormal_chromosome_stability	1.25042117
37	MP0004142_abnormal_muscle_tone	1.18806432
38	MP0002653_abnormal_ependyma_morphology	1.16136607
39	MP0001270_distended_abdomen	1.13111721
40	MP0008872_abnormal_physiological_respon	1.11534466
41	MP0002272_abnormal_nervous_system	1.11342818
42	MP0004215_abnormal_myocardial_fiber	1.06496236
43	MP0006035_abnormal_mitochondrial_morpho	1.06307824
44	MP0004043_abnormal_pH_regulation	1.05271035
45	MP0004381_abnormal_hair_follicle	1.05094538
46	MP0008789_abnormal_olfactory_epithelium	1.04780779
47	MP0003890_abnormal_embryonic-extraembry	1.04685883
48	MP0002160_abnormal_reproductive_system	1.04004755
49	MP0001486_abnormal_startle_reflex	1.03598135
50	MP0009745_abnormal_behavioral_response	1.03365966
51	MP0003937_abnormal_limbs/digits/tail_de	1.03185811
52	MP0002234_abnormal_pharynx_morphology	1.01970426
53	MP0005391_vision/eye_phenotype	1.00551462
54	MP0009046_muscle_twitch	1.00193732
55	MP0001919_abnormal_reproductive_system	0.99846058
56	MP0005499_abnormal_olfactory_system	0.98660201
57	MP0005394_taste/olfaction_phenotype	0.98660201
58	MP0010386_abnormal_urinary_bladder	0.97516707
59	MP0004924_abnormal_behavior	0.97434334
60	MP0005386_behavior/neurological_phenoty	0.97434334
61	MP0001929_abnormal_gametogenesis	0.97243373
62	MP0003763_abnormal_thymus_physiology	0.95981060
63	MP0003698_abnormal_male_reproductive	0.94750936
64	MP0003315_abnormal_perineum_morphology	0.94134903
65	MP0001485_abnormal_pinna_reflex	0.93935245
66	MP0002928_abnormal_bile_duct	0.91052195
67	MP0005389_reproductive_system_phenotype	0.90988717
68	MP0001502_abnormal_circadian_rhythm	0.90560785
69	MP0000778_abnormal_nervous_system	0.89790089
70	MP0006036_abnormal_mitochondrial_physio	0.89447557
71	MP0003011_delayed_dark_adaptation	0.88597624
72	MP0001324_abnormal_eye_pigmentation	0.88585046
73	MP0003567_abnormal_fetal_cardiomyocyte	0.88415931
74	MP0001286_abnormal_eye_development	0.88105814
75	MP0002184_abnormal_innervation	0.84986135
76	MP0002210_abnormal_sex_determination	0.84749597
77	MP0000427_abnormal_hair_cycle	0.84674248
78	MP0005410_abnormal_fertilization	0.83906716
79	MP0005645_abnormal_hypothalamus_physiol	0.83089972
80	MP0003718_maternal_effect	0.82848005
81	MP0008007_abnormal_cellular_replicative	0.82645019
82	MP0005174_abnormal_tail_pigmentation	0.81444654
83	MP0000653_abnormal_sex_gland	0.81324812
84	MP0001145_abnormal_male_reproductive	0.80272294
85	MP0005187_abnormal_penis_morphology	0.79759341
86	MP0005220_abnormal_exocrine_pancreas	0.79621646
87	MP0003786_premature_aging	0.78312378
88	MP0002095_abnormal_skin_pigmentation	0.78218381
89	MP0002938_white_spotting	0.78076620
90	MP0003119_abnormal_digestive_system	0.77274486
91	MP0002396_abnormal_hematopoietic_system	0.75938528
92	MP0001764_abnormal_homeostasis	0.75822580
93	MP0003077_abnormal_cell_cycle	0.75781403
94	MP0001293_anophthalmia	0.75610996
95	MP0002752_abnormal_somatic_nervous	0.73556178
96	MP0002067_abnormal_sensory_capabilities	0.72466559
97	MP0001501_abnormal_sleep_pattern	0.70995352
98	MP0005195_abnormal_posterior_eye	0.66556959
99	MP0005084_abnormal_gallbladder_morpholo	0.66300271
100	MP0000538_abnormal_urinary_bladder	0.66256267

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.84033982
2	Pancreatic fibrosis (HP:0100732)	3.37965730
3	Abnormality of the labia minora (HP:0012880)	3.31311682
4	Pendular nystagmus (HP:0012043)	3.31293888
5	True hermaphroditism (HP:0010459)	3.28246296
6	Hyperventilation (HP:0002883)	2.89446840
7	Chromsome breakage (HP:0040012)	2.72898282
8	Renal cortical cysts (HP:0000803)	2.71964634
9	Type II lissencephaly (HP:0007260)	2.68129080
10	Atonic seizures (HP:0010819)	2.67691037
11	Gaze-evoked nystagmus (HP:0000640)	2.66768731
12	Congenital stationary night blindness (HP:0007642)	2.66165935
13	Molar tooth sign on MRI (HP:0002419)	2.59060538
14	Abnormality of midbrain morphology (HP:0002418)	2.59060538
15	Nephronophthisis (HP:0000090)	2.57672939
16	Chronic hepatic failure (HP:0100626)	2.54113560
17	Cerebellar dysplasia (HP:0007033)	2.48992576
18	Inability to walk (HP:0002540)	2.41931881
19	Colon cancer (HP:0003003)	2.38223494
20	Abnormality of the renal cortex (HP:0011035)	2.37582126
21	Abnormal biliary tract physiology (HP:0012439)	2.35369942
22	Bile duct proliferation (HP:0001408)	2.35369942
23	Absent speech (HP:0001344)	2.32814424
24	Febrile seizures (HP:0002373)	2.30110002
25	Lissencephaly (HP:0001339)	2.25607048
26	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.25401630
27	Cystic liver disease (HP:0006706)	2.23638802
28	Abolished electroretinogram (ERG) (HP:0000550)	2.19471331
29	Abnormality of chromosome stability (HP:0003220)	2.18839092
30	Medial flaring of the eyebrow (HP:0010747)	2.18581022
31	Supernumerary spleens (HP:0009799)	2.18363556
32	Focal motor seizures (HP:0011153)	2.17691484
33	Anterior segment dysgenesis (HP:0007700)	2.12948793
34	Abnormal hair whorl (HP:0010721)	2.11596642
35	Broad-based gait (HP:0002136)	2.10550818
36	Intestinal atresia (HP:0011100)	2.09065333
37	Anencephaly (HP:0002323)	2.09023499
38	Protruding tongue (HP:0010808)	2.07745642
39	Panhypogammaglobulinemia (HP:0003139)	2.06947301
40	Abnormality of the renal medulla (HP:0100957)	2.06027636
41	Retinal dysplasia (HP:0007973)	2.03794574
42	Dialeptic seizures (HP:0011146)	2.03189197
43	Focal seizures (HP:0007359)	2.03174891
44	Abnormality of the ileum (HP:0001549)	2.01653578
45	Tubulointerstitial nephritis (HP:0001970)	2.01651241
46	Tubular atrophy (HP:0000092)	1.99106190
47	Sloping forehead (HP:0000340)	1.95614538
48	Thyroid-stimulating hormone excess (HP:0002925)	1.95589427
49	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.94834118
50	Meckel diverticulum (HP:0002245)	1.94222169
51	B lymphocytopenia (HP:0010976)	1.92777341
52	Attenuation of retinal blood vessels (HP:0007843)	1.92535755
53	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.91061586
54	Abnormality of B cell number (HP:0010975)	1.90888876
55	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.90119083
56	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.88633216
57	Abnormality of alanine metabolism (HP:0010916)	1.87060517
58	Hyperalaninemia (HP:0003348)	1.87060517
59	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.87060517
60	Progressive cerebellar ataxia (HP:0002073)	1.85969337
61	Prostate neoplasm (HP:0100787)	1.85810898
62	Dysdiadochokinesis (HP:0002075)	1.84896627
63	Birth length less than 3rd percentile (HP:0003561)	1.84031287
64	Hip dysplasia (HP:0001385)	1.81886918
65	Neoplasm of the adrenal cortex (HP:0100641)	1.80082899
66	Hypothermia (HP:0002045)	1.79403802
67	Acute lymphatic leukemia (HP:0006721)	1.79356277
68	Male pseudohermaphroditism (HP:0000037)	1.78427565
69	Pachygyria (HP:0001302)	1.78380949
70	Progressive inability to walk (HP:0002505)	1.78265755
71	Gait imbalance (HP:0002141)	1.77710226
72	Nephrogenic diabetes insipidus (HP:0009806)	1.76836109
73	Dandy-Walker malformation (HP:0001305)	1.74508189
74	Congenital primary aphakia (HP:0007707)	1.73994635
75	Absent thumb (HP:0009777)	1.73042389
76	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.72260770
77	Absent/shortened dynein arms (HP:0200106)	1.72260770
78	Narrow forehead (HP:0000341)	1.71738370
79	IgG deficiency (HP:0004315)	1.70989206
80	Patellar aplasia (HP:0006443)	1.69055330
81	Duplicated collecting system (HP:0000081)	1.68388947
82	Scrotal hypoplasia (HP:0000046)	1.67766464
83	Sclerocornea (HP:0000647)	1.66371082
84	Methylmalonic acidemia (HP:0002912)	1.66074430
85	Short tibia (HP:0005736)	1.65459960
86	Genetic anticipation (HP:0003743)	1.65404549
87	Abnormality of the renal collecting system (HP:0004742)	1.64966430
88	Abnormal rod and cone electroretinograms (HP:0008323)	1.64950270
89	Congenital hepatic fibrosis (HP:0002612)	1.63741458
90	Stomach cancer (HP:0012126)	1.62355076
91	Oculomotor apraxia (HP:0000657)	1.61305092
92	Absence seizures (HP:0002121)	1.60905118
93	Aplasia/hypoplasia of the uterus (HP:0008684)	1.60816227
94	Hyperglycinemia (HP:0002154)	1.60652562
95	Postaxial foot polydactyly (HP:0001830)	1.60191482
96	Thyroiditis (HP:0100646)	1.59807124
97	Abnormal respiratory epithelium morphology (HP:0012253)	1.58907463
98	Abnormal respiratory motile cilium morphology (HP:0005938)	1.58907463
99	Rimmed vacuoles (HP:0003805)	1.58359762
100	Clubbing of toes (HP:0100760)	1.57652397

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.85030690
2	PINK1	3.60547862
3	MAP4K2	3.19489476
4	BMPR1B	2.98463218
5	EIF2AK3	2.49454332
6	MARK3	2.33361774
7	WNK3	2.29508728
8	ZAK	2.21469093
9	TAOK3	2.15871227
10	NUAK1	2.06540067
11	MKNK2	1.98299089
12	CDK19	1.96807073
13	MAP2K7	1.85031984
14	MAPK13	1.81842940
15	CDK8	1.73540168
16	PLK4	1.68840648
17	OXSR1	1.65746226
18	MKNK1	1.64234656
19	MAP3K4	1.63857865
20	SRPK1	1.53632736
21	CASK	1.51386933
22	GRK1	1.46937309
23	ADRBK2	1.46667874
24	TGFBR1	1.44101354
25	DYRK3	1.35094697
26	ACVR1B	1.30909776
27	AKT3	1.29735587
28	NLK	1.29133033
29	CDK3	1.19421074
30	CSNK1G1	1.17803225
31	PAK3	1.15940782
32	CSNK1A1L	1.15902521
33	OBSCN	1.13265615
34	INSRR	1.12175807
35	BCR	1.11931879
36	CSNK1G3	1.11757348
37	NEK2	1.10453941
38	TRIM28	1.07985224
39	STK16	1.06685767
40	BRSK2	1.03425577
41	CSNK1G2	1.02045695
42	TLK1	0.98343339
43	SIK3	0.87325508
44	WNK4	0.85840981
45	ERBB3	0.85796448
46	PASK	0.84529304
47	WEE1	0.84435889
48	SIK2	0.83530185
49	BRD4	0.83115123
50	PRKCE	0.81624322
51	PLK2	0.81391880
52	PRKCQ	0.80409010
53	KIT	0.79811523
54	RAF1	0.78868389
55	MARK1	0.78229285
56	CDC7	0.76700798
57	VRK1	0.75661439
58	STK38L	0.74444394
59	ATM	0.73452261
60	ATR	0.72871336
61	STK11	0.70441693
62	FGFR2	0.69717910
63	RPS6KA5	0.68226388
64	CCNB1	0.66748057
65	RPS6KB1	0.64060161
66	CAMKK2	0.63819044
67	STK39	0.62640104
68	SGK2	0.62597205
69	MAP4K1	0.62096530
70	TNK2	0.61927195
71	RPS6KA4	0.60071541
72	DYRK2	0.58478244
73	TEC	0.57337645
74	MAP3K7	0.56970123
75	TNIK	0.56952646
76	TSSK6	0.56897513
77	STK3	0.53063170
78	DAPK2	0.52202362
79	SGK494	0.51904349
80	SGK223	0.51904349
81	CSNK1A1	0.51315378
82	PLK3	0.51165446
83	IKBKE	0.46313617
84	CSNK1D	0.46232297
85	PIM1	0.44533471
86	TXK	0.41211420
87	PRKCG	0.41084368
88	PKN1	0.39624610
89	DYRK1A	0.38974678
90	IKBKB	0.38081891
91	MAPK12	0.36499581
92	MELK	0.34249440
93	CSNK1E	0.33329173
94	FLT3	0.30960323
95	LATS1	0.30377771
96	PRKAA1	0.29470246
97	SGK1	0.29467772
98	PRKG1	0.29464958
99	CHEK1	0.29355174
100	ADRBK1	0.28485740

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.68833947
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.19460056
3	Phototransduction_Homo sapiens_hsa04744	2.69636964
4	Basal transcription factors_Homo sapiens_hsa03022	2.60940179
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.58155098
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.48558417
7	Homologous recombination_Homo sapiens_hsa03440	2.47268334
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.40322471
9	RNA polymerase_Homo sapiens_hsa03020	2.32365362
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.21670177
11	Butanoate metabolism_Homo sapiens_hsa00650	2.09392035
12	RNA degradation_Homo sapiens_hsa03018	2.07919643
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.07031607
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.95684277
15	Olfactory transduction_Homo sapiens_hsa04740	1.93614568
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.84543372
17	Propanoate metabolism_Homo sapiens_hsa00640	1.69170355
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.65998514
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63550005
20	Protein export_Homo sapiens_hsa03060	1.62628565
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.52898321
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.50718048
23	Circadian rhythm_Homo sapiens_hsa04710	1.45184088
24	Base excision repair_Homo sapiens_hsa03410	1.44248232
25	Taste transduction_Homo sapiens_hsa04742	1.42256752
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.37307813
27	Nicotine addiction_Homo sapiens_hsa05033	1.34516446
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.32084562
29	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.26465125
30	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.23418875
31	RNA transport_Homo sapiens_hsa03013	1.23247431
32	Primary immunodeficiency_Homo sapiens_hsa05340	1.22179370
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.18120252
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.12166264
35	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.07887236
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.07681520
37	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.03894186
38	mRNA surveillance pathway_Homo sapiens_hsa03015	1.03453014
39	Spliceosome_Homo sapiens_hsa03040	1.01702462
40	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.00138969
41	Purine metabolism_Homo sapiens_hsa00230	0.98059028
42	Mismatch repair_Homo sapiens_hsa03430	0.87829075
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.80676596
44	One carbon pool by folate_Homo sapiens_hsa00670	0.80526053
45	DNA replication_Homo sapiens_hsa03030	0.80182014
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.79345001
47	GABAergic synapse_Homo sapiens_hsa04727	0.78594138
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77552073
49	ABC transporters_Homo sapiens_hsa02010	0.76741937
50	Circadian entrainment_Homo sapiens_hsa04713	0.75359110
51	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.74683424
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.74290191
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.73961743
54	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.73564913
55	Caffeine metabolism_Homo sapiens_hsa00232	0.73011216
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.70239624
57	Long-term depression_Homo sapiens_hsa04730	0.68544278
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66952107
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65999246
60	Lysine degradation_Homo sapiens_hsa00310	0.64228024
61	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.63917718
62	Regulation of autophagy_Homo sapiens_hsa04140	0.61869874
63	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61718577
64	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.61434903
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60728191
66	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.60517838
67	Oocyte meiosis_Homo sapiens_hsa04114	0.59947002
68	Peroxisome_Homo sapiens_hsa04146	0.56938985
69	Alcoholism_Homo sapiens_hsa05034	0.56098484
70	Parkinsons disease_Homo sapiens_hsa05012	0.55026512
71	Morphine addiction_Homo sapiens_hsa05032	0.54799005
72	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52588410
73	Dopaminergic synapse_Homo sapiens_hsa04728	0.51519686
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51312964
75	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.48349475
76	Renin secretion_Homo sapiens_hsa04924	0.47059557
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46249377
78	Calcium signaling pathway_Homo sapiens_hsa04020	0.45269673
79	Salivary secretion_Homo sapiens_hsa04970	0.45132205
80	Tryptophan metabolism_Homo sapiens_hsa00380	0.44161920
81	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.43177265
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41516488
83	Glutamatergic synapse_Homo sapiens_hsa04724	0.41151974
84	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.41045480
85	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.40688674
86	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.40475419
87	Cell cycle_Homo sapiens_hsa04110	0.40287570
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.39601565
89	Amphetamine addiction_Homo sapiens_hsa05031	0.39385171
90	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.38599760
91	cAMP signaling pathway_Homo sapiens_hsa04024	0.37218817
92	Herpes simplex infection_Homo sapiens_hsa05168	0.36523592
93	Retinol metabolism_Homo sapiens_hsa00830	0.35680075
94	Asthma_Homo sapiens_hsa05310	0.34698587
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.34602549
96	Type I diabetes mellitus_Homo sapiens_hsa04940	0.32233828
97	Serotonergic synapse_Homo sapiens_hsa04726	0.32122959
98	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.29578518
99	Metabolic pathways_Homo sapiens_hsa01100	0.29186115
100	FoxO signaling pathway_Homo sapiens_hsa04068	0.28412494

ZNF550

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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