ZNF551

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)4.42796020
2regulation of gene silencing by RNA (GO:0060966)4.21520156
3regulation of posttranscriptional gene silencing (GO:0060147)4.21520156
4regulation of gene silencing by miRNA (GO:0060964)4.21520156
5somatic diversification of immune receptors via somatic mutation (GO:0002566)4.20338762
6somatic hypermutation of immunoglobulin genes (GO:0016446)4.20338762
7pre-miRNA processing (GO:0031054)4.15290003
8CENP-A containing nucleosome assembly (GO:0034080)4.13337145
9DNA double-strand break processing (GO:0000729)4.01788627
10regulation of centriole replication (GO:0046599)3.96918003
11DNA replication checkpoint (GO:0000076)3.95332499
12negative regulation of translation, ncRNA-mediated (GO:0040033)3.94747742
13regulation of translation, ncRNA-mediated (GO:0045974)3.94747742
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.94747742
15DNA strand elongation involved in DNA replication (GO:0006271)3.93292949
16DNA replication-dependent nucleosome assembly (GO:0006335)3.83694349
17DNA replication-dependent nucleosome organization (GO:0034723)3.83694349
18negative regulation of DNA-dependent DNA replication (GO:2000104)3.81172539
19nuclear pore complex assembly (GO:0051292)3.77272862
20DNA strand elongation (GO:0022616)3.75741315
21regulation of helicase activity (GO:0051095)3.72558728
22histone exchange (GO:0043486)3.66835310
23regulation of nuclear cell cycle DNA replication (GO:0033262)3.61140418
24mitotic sister chromatid cohesion (GO:0007064)3.60099393
25negative regulation of DNA recombination (GO:0045910)3.60084206
26nuclear pore organization (GO:0006999)3.54873380
27DNA unwinding involved in DNA replication (GO:0006268)3.52708665
28DNA replication-independent nucleosome assembly (GO:0006336)3.51987924
29DNA replication-independent nucleosome organization (GO:0034724)3.51987924
30protein localization to kinetochore (GO:0034501)3.47116227
31negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.46488325
32negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.46488325
33negative regulation of mitotic sister chromatid segregation (GO:0033048)3.46488325
34negative regulation of mitotic sister chromatid separation (GO:2000816)3.46488325
35negative regulation of sister chromatid segregation (GO:0033046)3.46488325
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.46043515
37regulation of mitotic spindle checkpoint (GO:1903504)3.46043515
38regulation of histone H3-K9 methylation (GO:0051570)3.45868214
39negative regulation of chromosome segregation (GO:0051985)3.45354040
40DNA replication initiation (GO:0006270)3.37506713
41mitotic sister chromatid segregation (GO:0000070)3.36043415
42sister chromatid segregation (GO:0000819)3.32009281
43centriole replication (GO:0007099)3.31354216
44telomere maintenance via semi-conservative replication (GO:0032201)3.22898021
45spindle checkpoint (GO:0031577)3.22436287
46DNA ligation (GO:0006266)3.21991002
47mitotic spindle checkpoint (GO:0071174)3.21530905
48attachment of spindle microtubules to kinetochore (GO:0008608)3.19917584
49regulation of DNA endoreduplication (GO:0032875)3.17651979
50mitotic metaphase plate congression (GO:0007080)3.16865278
51regulation of sister chromatid segregation (GO:0033045)3.16566081
52regulation of mitotic sister chromatid separation (GO:0010965)3.16566081
53regulation of mitotic sister chromatid segregation (GO:0033047)3.16566081
54regulation of mitotic metaphase/anaphase transition (GO:0030071)3.15145027
55regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.15145027
56DNA catabolic process, exonucleolytic (GO:0000738)3.13041914
57protein localization to chromosome, centromeric region (GO:0071459)3.13017954
58double-strand break repair via nonhomologous end joining (GO:0006303)3.12767482
59non-recombinational repair (GO:0000726)3.12767482
60replication fork processing (GO:0031297)3.12681511
61kinetochore organization (GO:0051383)3.11254834
62mitotic spindle assembly checkpoint (GO:0007094)3.10152146
63establishment of integrated proviral latency (GO:0075713)3.06391859
64spindle assembly checkpoint (GO:0071173)3.04463046
65regulation of gene silencing (GO:0060968)3.03771924
66metaphase plate congression (GO:0051310)3.03675828
67recombinational repair (GO:0000725)3.03056395
68RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.02146906
69double-strand break repair via homologous recombination (GO:0000724)3.01670002
70ncRNA catabolic process (GO:0034661)3.00672353
71telomere maintenance via recombination (GO:0000722)2.98896307
72nucleobase biosynthetic process (GO:0046112)2.97669725
73IMP biosynthetic process (GO:0006188)2.97143659
74regulation of chromosome segregation (GO:0051983)2.96090193
75regulation of centrosome duplication (GO:0010824)2.95060636
76regulation of centrosome cycle (GO:0046605)2.93992780
77postreplication repair (GO:0006301)2.92811341
78mitotic recombination (GO:0006312)2.92396407
79mitotic nuclear envelope disassembly (GO:0007077)2.90562041
80kinetochore assembly (GO:0051382)2.89799243
81monoubiquitinated protein deubiquitination (GO:0035520)2.86696299
82regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85232227
83purine nucleobase biosynthetic process (GO:0009113)2.84753914
84mitotic G2/M transition checkpoint (GO:0044818)2.84440016
85ATP-dependent chromatin remodeling (GO:0043044)2.82878639
86DNA geometric change (GO:0032392)2.82703574
87pore complex assembly (GO:0046931)2.82080388
88chromatin assembly or disassembly (GO:0006333)2.81701485
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.81699290
90telomere maintenance via telomerase (GO:0007004)2.81693414
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80602313
92DNA topological change (GO:0006265)2.79959209
93DNA duplex unwinding (GO:0032508)2.79079760
94negative regulation of histone methylation (GO:0031061)2.78591603
95somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.78297154
96somatic cell DNA recombination (GO:0016444)2.78297154
97positive regulation of histone H3-K4 methylation (GO:0051571)2.77787598
98meiotic chromosome segregation (GO:0045132)2.75388995
99somatic diversification of immune receptors (GO:0002200)2.75101422
100protein K6-linked ubiquitination (GO:0085020)2.74474389

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.65651709
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.21635383
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.65540407
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.45737296
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.45146126
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34969931
7* EST1_17652178_ChIP-ChIP_JURKAT_Human2.78868471
8ZNF274_21170338_ChIP-Seq_K562_Hela2.78465147
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.78198140
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77129390
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.66819889
12* GABP_17652178_ChIP-ChIP_JURKAT_Human2.63614491
13ELK1_19687146_ChIP-ChIP_HELA_Human2.50938301
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.46150069
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.42918909
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41315165
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39295440
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.17698364
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.17057854
20VDR_23849224_ChIP-Seq_CD4+_Human2.12861164
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12393067
22EWS_26573619_Chip-Seq_HEK293_Human2.02754708
23FUS_26573619_Chip-Seq_HEK293_Human2.00302159
24FOXP3_21729870_ChIP-Seq_TREG_Human1.96390112
25IGF1R_20145208_ChIP-Seq_DFB_Human1.89895621
26IRF1_19129219_ChIP-ChIP_H3396_Human1.89286811
27YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86768910
28* ETS1_20019798_ChIP-Seq_JURKAT_Human1.85271343
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83713427
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75905027
31VDR_22108803_ChIP-Seq_LS180_Human1.74642303
32MYC_18940864_ChIP-ChIP_HL60_Human1.74371243
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73636406
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71135519
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69813600
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68098030
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67705735
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67616534
39SOX2_16153702_ChIP-ChIP_HESCs_Human1.61747317
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57889523
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53092072
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52220099
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47322797
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44606123
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.42829669
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40926194
47TTF2_22483619_ChIP-Seq_HELA_Human1.40523337
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38795339
49* NANOG_16153702_ChIP-ChIP_HESCs_Human1.32887399
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29714239
51P300_19829295_ChIP-Seq_ESCs_Human1.28242477
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26212868
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24073406
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23736110
55DCP1A_22483619_ChIP-Seq_HELA_Human1.22641702
56CIITA_25753668_ChIP-Seq_RAJI_Human1.21557134
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18602180
58* GABP_19822575_ChIP-Seq_HepG2_Human1.18240103
59AR_21909140_ChIP-Seq_LNCAP_Human1.16823499
60KDM5A_27292631_Chip-Seq_BREAST_Human1.16119472
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15770944
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13839747
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13839747
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13839747
65SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12842142
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11673987
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09969540
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08891036
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08608464
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03934019
71TAF15_26573619_Chip-Seq_HEK293_Human1.03719271
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03203285
73XRN2_22483619_ChIP-Seq_HELA_Human1.01370997
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01217344
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01217344
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.00913988
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00539871
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.00321324
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00241270
80PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99154830
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98587185
82CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97582486
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97412951
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95069377
85SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94954053
86ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94650744
87GBX2_23144817_ChIP-Seq_PC3_Human0.94078027
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92681911
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87930690
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87848051
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87467363
92ER_23166858_ChIP-Seq_MCF-7_Human0.87449398
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84247586
94PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84214715
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80904463
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.79290821
97STAT3_23295773_ChIP-Seq_U87_Human0.76508982
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.74367089
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.73782106
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.73352775

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.97835962
2MP0010094_abnormal_chromosome_stability4.28573091
3MP0003693_abnormal_embryo_hatching3.74354708
4MP0008058_abnormal_DNA_repair3.65428711
5MP0008877_abnormal_DNA_methylation3.51517645
6MP0003111_abnormal_nucleus_morphology3.29892806
7MP0003077_abnormal_cell_cycle2.85317261
8MP0006292_abnormal_olfactory_placode2.84218313
9MP0004957_abnormal_blastocyst_morpholog2.77071062
10MP0003890_abnormal_embryonic-extraembry2.52066207
11MP0003136_yellow_coat_color2.46692292
12MP0001293_anophthalmia2.05178218
13MP0009697_abnormal_copulation1.99788872
14MP0008007_abnormal_cellular_replicative1.99426353
15MP0003718_maternal_effect1.96915687
16MP0008932_abnormal_embryonic_tissue1.93845373
17MP0003787_abnormal_imprinting1.82450440
18MP0001529_abnormal_vocalization1.82220123
19MP0000569_abnormal_digit_pigmentation1.76675248
20MP0003121_genomic_imprinting1.74862102
21MP0002102_abnormal_ear_morphology1.66262877
22MP0003567_abnormal_fetal_cardiomyocyte1.64915304
23MP0003937_abnormal_limbs/digits/tail_de1.63529070
24MP0009672_abnormal_birth_weight1.44204921
25MP0003786_premature_aging1.44015180
26MP0000350_abnormal_cell_proliferation1.41416354
27MP0002009_preneoplasia1.40741015
28MP0004133_heterotaxia1.39653297
29MP0001286_abnormal_eye_development1.38934580
30MP0006072_abnormal_retinal_apoptosis1.38399230
31MP0002396_abnormal_hematopoietic_system1.36194428
32MP0010307_abnormal_tumor_latency1.35333867
33MP0004197_abnormal_fetal_growth/weight/1.33736078
34MP0001672_abnormal_embryogenesis/_devel1.33022851
35MP0005380_embryogenesis_phenotype1.33022851
36MP0001697_abnormal_embryo_size1.31174277
37MP0002084_abnormal_developmental_patter1.30265962
38MP0006035_abnormal_mitochondrial_morpho1.25823182
39MP0001730_embryonic_growth_arrest1.25722562
40MP0002085_abnormal_embryonic_tissue1.25236424
41MP0009703_decreased_birth_body1.24698725
42MP0003941_abnormal_skin_development1.22926128
43MP0002938_white_spotting1.22415833
44MP0002210_abnormal_sex_determination1.21973011
45MP0000372_irregular_coat_pigmentation1.21345083
46MP0003119_abnormal_digestive_system1.20043040
47MP0001929_abnormal_gametogenesis1.18746800
48MP0003984_embryonic_growth_retardation1.18732741
49MP0002254_reproductive_system_inflammat1.18393124
50MP0002088_abnormal_embryonic_growth/wei1.17268167
51MP0008995_early_reproductive_senescence1.16781321
52MP0000631_abnormal_neuroendocrine_gland1.13060581
53MP0001188_hyperpigmentation1.12447888
54MP0002697_abnormal_eye_size1.09733414
55MP0001145_abnormal_male_reproductive1.05096449
56MP0008789_abnormal_olfactory_epithelium1.05068732
57MP0005253_abnormal_eye_physiology1.03403697
58MP0005394_taste/olfaction_phenotype1.01627110
59MP0005499_abnormal_olfactory_system1.01627110
60MP0004147_increased_porphyrin_level0.99266247
61MP0000653_abnormal_sex_gland0.98403003
62MP0005075_abnormal_melanosome_morpholog0.97721488
63MP0002080_prenatal_lethality0.94959630
64MP0000313_abnormal_cell_death0.94482254
65MP0002233_abnormal_nose_morphology0.94043411
66MP0003861_abnormal_nervous_system0.92932454
67MP0003646_muscle_fatigue0.92803152
68MP0002111_abnormal_tail_morphology0.92425802
69MP0002822_catalepsy0.91300331
70MP0005391_vision/eye_phenotype0.89859789
71MP0010352_gastrointestinal_tract_polyps0.89071496
72MP0003698_abnormal_male_reproductive0.88080228
73MP0003943_abnormal_hepatobiliary_system0.86287638
74MP0005174_abnormal_tail_pigmentation0.84878923
75MP0002751_abnormal_autonomic_nervous0.83573649
76MP0000358_abnormal_cell_content/0.81272865
77MP0001485_abnormal_pinna_reflex0.79869710
78MP0001119_abnormal_female_reproductive0.79650957
79MP0000049_abnormal_middle_ear0.79611600
80MP0006276_abnormal_autonomic_nervous0.78254649
81MP0003122_maternal_imprinting0.77927414
82MP0002638_abnormal_pupillary_reflex0.76969624
83MP0002095_abnormal_skin_pigmentation0.76906447
84MP0008961_abnormal_basal_metabolism0.75789386
85MP0001177_atelectasis0.73826108
86MP0004142_abnormal_muscle_tone0.72914412
87MP0000778_abnormal_nervous_system0.72459386
88MP0002086_abnormal_extraembryonic_tissu0.71633740
89MP0000015_abnormal_ear_pigmentation0.70079793
90MP0002019_abnormal_tumor_incidence0.69402512
91MP0005367_renal/urinary_system_phenotyp0.68819014
92MP0000516_abnormal_urinary_system0.68819014
93MP0001919_abnormal_reproductive_system0.68487550
94MP0001984_abnormal_olfaction0.68332908
95MP0002092_abnormal_eye_morphology0.67560742
96MP0009046_muscle_twitch0.67223324
97MP0002160_abnormal_reproductive_system0.66531982
98MP0004808_abnormal_hematopoietic_stem0.65901551
99MP0000647_abnormal_sebaceous_gland0.65673793
100MP0002163_abnormal_gland_morphology0.65639782

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.06857070
2Colon cancer (HP:0003003)3.96889496
3Chromsome breakage (HP:0040012)3.82769192
4Abnormality of the labia minora (HP:0012880)3.46264680
5Abnormality of chromosome stability (HP:0003220)3.31722449
6Aplasia/Hypoplasia of the uvula (HP:0010293)3.23251810
7Meckel diverticulum (HP:0002245)3.17761250
8Birth length less than 3rd percentile (HP:0003561)3.16787545
9Abnormality of the ileum (HP:0001549)3.10146239
10Abnormality of the preputium (HP:0100587)2.70706733
11Pancreatic cysts (HP:0001737)2.56784810
12Medulloblastoma (HP:0002885)2.53535104
13Volvulus (HP:0002580)2.49955041
14Nephroblastoma (Wilms tumor) (HP:0002667)2.47549513
15Small intestinal stenosis (HP:0012848)2.41635418
16Duodenal stenosis (HP:0100867)2.41635418
17Sloping forehead (HP:0000340)2.35941036
18Ectopic kidney (HP:0000086)2.31986577
19Embryonal renal neoplasm (HP:0011794)2.31249999
20Ependymoma (HP:0002888)2.29383852
21Abnormality of the duodenum (HP:0002246)2.25264431
22Clubbing of toes (HP:0100760)2.25122058
23Pancreatic fibrosis (HP:0100732)2.24444078
24Patellar aplasia (HP:0006443)2.23969794
25Glioma (HP:0009733)2.17534602
26Carpal bone hypoplasia (HP:0001498)2.16857307
27Abnormality of the carotid arteries (HP:0005344)2.16610394
28Hypoplasia of the pons (HP:0012110)2.14419520
29Neoplasm of the adrenal cortex (HP:0100641)2.13435014
30Acute lymphatic leukemia (HP:0006721)2.12374336
31Bilateral microphthalmos (HP:0007633)2.11094822
32Protruding tongue (HP:0010808)2.09044498
33Nephronophthisis (HP:0000090)2.09010456
34Abnormality of the pons (HP:0007361)2.08617684
35Septo-optic dysplasia (HP:0100842)2.07433408
36Abnormal lung lobation (HP:0002101)2.04748182
37Chronic hepatic failure (HP:0100626)2.01282759
38Triphalangeal thumb (HP:0001199)2.00832253
39Progressive inability to walk (HP:0002505)2.00626933
40Rhabdomyosarcoma (HP:0002859)2.00226815
41Molar tooth sign on MRI (HP:0002419)1.98715173
42Abnormality of midbrain morphology (HP:0002418)1.98715173
43Aplasia/Hypoplasia of the patella (HP:0006498)1.98528820
44Optic nerve hypoplasia (HP:0000609)1.98132553
45Absent radius (HP:0003974)1.97893155
46Inability to walk (HP:0002540)1.97702512
47Abnormality of the septum pellucidum (HP:0007375)1.97251181
48Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97243950
49Impulsivity (HP:0100710)1.96823346
50Aplasia/Hypoplasia of the sternum (HP:0006714)1.96690493
51True hermaphroditism (HP:0010459)1.94730521
52Absent forearm bone (HP:0003953)1.94441203
53Aplasia involving forearm bones (HP:0009822)1.94441203
54Intestinal atresia (HP:0011100)1.89599824
55Myelodysplasia (HP:0002863)1.88475839
56Partial agenesis of the corpus callosum (HP:0001338)1.86767522
57Abnormality of the renal medulla (HP:0100957)1.86391151
58Bile duct proliferation (HP:0001408)1.86370865
59Abnormal biliary tract physiology (HP:0012439)1.86370865
60Hepatoblastoma (HP:0002884)1.85447831
61Lissencephaly (HP:0001339)1.83459190
62Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82468429
63Esophageal atresia (HP:0002032)1.80742807
64Supernumerary spleens (HP:0009799)1.80267893
65Genetic anticipation (HP:0003743)1.78959050
66Abnormality of cochlea (HP:0000375)1.78515708
67Stomach cancer (HP:0012126)1.78354628
68Gastrointestinal atresia (HP:0002589)1.78244040
69Diastasis recti (HP:0001540)1.76537867
70Dandy-Walker malformation (HP:0001305)1.76401465
71Hyperglycinuria (HP:0003108)1.75895182
72Abnormal hair whorl (HP:0010721)1.74949754
73Cortical dysplasia (HP:0002539)1.74168128
74Hyperglycinemia (HP:0002154)1.72746426
75Absent septum pellucidum (HP:0001331)1.71689509
76Drooling (HP:0002307)1.70821629
77Abnormal number of incisors (HP:0011064)1.70177504
78Small hand (HP:0200055)1.69717272
79Basal cell carcinoma (HP:0002671)1.69044294
80Neoplasm of the oral cavity (HP:0100649)1.66490509
81Pendular nystagmus (HP:0012043)1.66432729
82Astrocytoma (HP:0009592)1.65717683
83Abnormality of the astrocytes (HP:0100707)1.65717683
84Broad-based gait (HP:0002136)1.65550473
85Horseshoe kidney (HP:0000085)1.64985166
86Preaxial hand polydactyly (HP:0001177)1.63674973
87Biliary tract neoplasm (HP:0100574)1.62748692
88Neoplasm of the colon (HP:0100273)1.62048898
89Medial flaring of the eyebrow (HP:0010747)1.61382492
90Poor coordination (HP:0002370)1.58928397
91IgM deficiency (HP:0002850)1.58756153
92Oligodactyly (hands) (HP:0001180)1.58754992
93Embryonal neoplasm (HP:0002898)1.56246488
94Anophthalmia (HP:0000528)1.54680432
95Hypoplastic iliac wings (HP:0002866)1.54355635
96Abnormality of the renal cortex (HP:0011035)1.54107112
97Reticulocytopenia (HP:0001896)1.53533923
98Hyperventilation (HP:0002883)1.53455357
99Genital tract atresia (HP:0001827)1.53435894
100Gaze-evoked nystagmus (HP:0000640)1.53206456

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.89458945
2ZAK3.70465429
3MKNK23.19746971
4SRPK12.70628017
5MKNK12.65658698
6PLK42.63584158
7BRSK22.63226320
8BUB12.54760855
9TSSK62.52575444
10NUAK12.35945054
11TTK2.31024697
12STK38L2.08641305
13BMPR1B2.01466636
14VRK11.99764421
15WEE11.95157362
16PLK31.93607596
17CASK1.92959721
18TNIK1.92637489
19EIF2AK31.78394532
20FRK1.77202815
21WNK31.69795955
22ACVR1B1.66651374
23TAF11.65798069
24TRIM281.57501537
25CHEK21.57366741
26MAP3K101.52103789
27PLK11.50527282
28ATR1.47608742
29TLK11.47570597
30MAP3K41.41383003
31NLK1.39799292
32PNCK1.37474002
33BRD41.36571188
34VRK21.26611201
35PASK1.24269539
36MST41.12693300
37ATM1.09353174
38DYRK31.03886502
39PBK1.03249212
40CSNK1G11.01581432
41CAMK1G0.99606887
42NEK10.97417428
43CDK120.94368657
44CAMK1D0.93971373
45BCR0.93071277
46DYRK20.91159485
47CHEK10.90594368
48TEC0.89314747
49TGFBR10.86484805
50AURKB0.86395823
51NEK20.85855249
52EIF2AK20.85832969
53STK30.83215219
54INSRR0.82554943
55BRSK10.82314142
56CCNB10.81279339
57EIF2AK10.81022408
58MAP2K70.78402569
59CSNK1G20.73840028
60MAPK130.73351105
61CSNK1A1L0.73230953
62MELK0.72660033
63CDK30.71632132
64GRK10.68249373
65CSNK1G30.67888109
66CDK40.66302857
67NME10.65017583
68RPS6KA40.63571926
69CDK20.62715733
70RPS6KA50.62602823
71PIM10.60501488
72CDK70.59831647
73CDK10.58541655
74FLT30.56425190
75MAP4K20.56266995
76PINK10.53758621
77ERBB40.53195124
78FGFR10.51507258
79PRKDC0.48796527
80STK40.46477660
81LATS10.45830055
82FGFR20.43211563
83CDK60.41369537
84ADRBK20.41269908
85OXSR10.41132204
86CDK190.39449312
87MARK30.38409411
88CSNK1D0.37016731
89DYRK1A0.36659973
90CSNK1E0.36288377
91WNK10.35280747
92ERBB30.34424123
93CLK10.33821421
94GSK3B0.33770119
95STK240.33347018
96AURKA0.32864280
97CSNK2A10.32114680
98AKT30.30710904
99CSNK2A20.28386198
100MAPK140.28218674

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.18698976
2Non-homologous end-joining_Homo sapiens_hsa034503.78155739
3Mismatch repair_Homo sapiens_hsa034303.77154117
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.53563918
5Fanconi anemia pathway_Homo sapiens_hsa034603.35145247
6Homologous recombination_Homo sapiens_hsa034403.25169445
7Base excision repair_Homo sapiens_hsa034103.01851559
8RNA polymerase_Homo sapiens_hsa030202.81359582
9Spliceosome_Homo sapiens_hsa030402.80554300
10Cell cycle_Homo sapiens_hsa041102.68792030
11RNA transport_Homo sapiens_hsa030132.68196069
12RNA degradation_Homo sapiens_hsa030182.65104608
13Selenocompound metabolism_Homo sapiens_hsa004502.52365410
14Basal transcription factors_Homo sapiens_hsa030222.48428554
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40294095
16Nucleotide excision repair_Homo sapiens_hsa034202.18952140
17mRNA surveillance pathway_Homo sapiens_hsa030151.93578070
18One carbon pool by folate_Homo sapiens_hsa006701.83531141
19Proteasome_Homo sapiens_hsa030501.80913513
20Pyrimidine metabolism_Homo sapiens_hsa002401.60262036
21Steroid biosynthesis_Homo sapiens_hsa001001.58827229
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50975251
23Protein export_Homo sapiens_hsa030601.48388851
24p53 signaling pathway_Homo sapiens_hsa041151.39938939
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36983238
26Propanoate metabolism_Homo sapiens_hsa006401.33782854
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.30579364
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29535759
29Ribosome_Homo sapiens_hsa030101.25934017
30Purine metabolism_Homo sapiens_hsa002301.20288301
31Lysine degradation_Homo sapiens_hsa003101.17053559
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15382232
33Phototransduction_Homo sapiens_hsa047441.13999622
34Systemic lupus erythematosus_Homo sapiens_hsa053221.08219939
35Oocyte meiosis_Homo sapiens_hsa041141.03492115
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00953426
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96048814
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87351977
39Alcoholism_Homo sapiens_hsa050340.84352718
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79746151
41Primary immunodeficiency_Homo sapiens_hsa053400.79400787
42Nicotine addiction_Homo sapiens_hsa050330.79071545
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77672385
44TGF-beta signaling pathway_Homo sapiens_hsa043500.77639742
45Huntingtons disease_Homo sapiens_hsa050160.76446962
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75752147
47Butanoate metabolism_Homo sapiens_hsa006500.74563873
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72593512
49Taste transduction_Homo sapiens_hsa047420.72050575
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71002543
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69165933
52Hippo signaling pathway_Homo sapiens_hsa043900.68445182
53Nitrogen metabolism_Homo sapiens_hsa009100.67811627
54Basal cell carcinoma_Homo sapiens_hsa052170.66786438
55Epstein-Barr virus infection_Homo sapiens_hsa051690.64689918
56Viral carcinogenesis_Homo sapiens_hsa052030.64623639
57Regulation of autophagy_Homo sapiens_hsa041400.63168141
58Parkinsons disease_Homo sapiens_hsa050120.61913583
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61826630
60MicroRNAs in cancer_Homo sapiens_hsa052060.61258010
61Colorectal cancer_Homo sapiens_hsa052100.60425143
62Circadian rhythm_Homo sapiens_hsa047100.57091230
63Hedgehog signaling pathway_Homo sapiens_hsa043400.56634398
64Wnt signaling pathway_Homo sapiens_hsa043100.56075890
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55435716
66Oxidative phosphorylation_Homo sapiens_hsa001900.53461445
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46472740
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44764366
69Prostate cancer_Homo sapiens_hsa052150.38120363
70Metabolic pathways_Homo sapiens_hsa011000.34762077
71Pyruvate metabolism_Homo sapiens_hsa006200.33545136
72Olfactory transduction_Homo sapiens_hsa047400.33018101
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32587833
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31635972
75Herpes simplex infection_Homo sapiens_hsa051680.30532878
76Linoleic acid metabolism_Homo sapiens_hsa005910.30300896
77Peroxisome_Homo sapiens_hsa041460.27862400
78Ether lipid metabolism_Homo sapiens_hsa005650.25913721
79HTLV-I infection_Homo sapiens_hsa051660.23539959
80Melanoma_Homo sapiens_hsa052180.23442176
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.23254340
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22145250
83Thyroid cancer_Homo sapiens_hsa052160.20924222
84FoxO signaling pathway_Homo sapiens_hsa040680.19336063
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.19204570
86Biosynthesis of amino acids_Homo sapiens_hsa012300.18710131
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18482086
88Adherens junction_Homo sapiens_hsa045200.15855067
89Long-term depression_Homo sapiens_hsa047300.15774243
90Tryptophan metabolism_Homo sapiens_hsa003800.14089942
91Serotonergic synapse_Homo sapiens_hsa047260.13618188
92Hepatitis B_Homo sapiens_hsa051610.13237277
93Vitamin digestion and absorption_Homo sapiens_hsa049770.12350314
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.11623505
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08936072
96Sulfur relay system_Homo sapiens_hsa041220.07276352
97Alzheimers disease_Homo sapiens_hsa050100.06884204
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.06326346
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04151655
100Pathways in cancer_Homo sapiens_hsa052000.03363182

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