ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.30944845
2	fucose catabolic process (GO:0019317)	4.51045325
3	L-fucose metabolic process (GO:0042354)	4.51045325
4	L-fucose catabolic process (GO:0042355)	4.51045325
5	neuron cell-cell adhesion (GO:0007158)	4.33866683
6	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.16735997
7	response to pheromone (GO:0019236)	3.78122014
8	kynurenine metabolic process (GO:0070189)	3.65397485
9	tryptophan catabolic process (GO:0006569)	3.57735134
10	indole-containing compound catabolic process (GO:0042436)	3.57735134
11	indolalkylamine catabolic process (GO:0046218)	3.57735134
12	atrial cardiac muscle cell action potential (GO:0086014)	3.55407272
13	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.51837542
14	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.43333602
15	negative regulation of telomere maintenance (GO:0032205)	3.33765130
16	platelet dense granule organization (GO:0060155)	3.32345157
17	indolalkylamine metabolic process (GO:0006586)	3.27003694
18	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.26608932
19	somite development (GO:0061053)	3.22494307
20	nephron epithelium morphogenesis (GO:0072088)	3.22358483
21	nephron tubule morphogenesis (GO:0072078)	3.22358483
22	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.21988582
23	negative regulation of mast cell activation (GO:0033004)	3.21276091
24	DNA deamination (GO:0045006)	3.18468708
25	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.16257850
26	kidney morphogenesis (GO:0060993)	3.15139866
27	cellular ketone body metabolic process (GO:0046950)	3.14873583
28	neuronal action potential (GO:0019228)	3.11212646
29	piRNA metabolic process (GO:0034587)	3.10189745
30	primary amino compound metabolic process (GO:1901160)	3.09745412
31	reflex (GO:0060004)	3.08131916
32	detection of light stimulus involved in sensory perception (GO:0050962)	3.07667184
33	detection of light stimulus involved in visual perception (GO:0050908)	3.07667184
34	neural tube formation (GO:0001841)	3.07456981
35	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.02438910
36	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.02438910
37	regulation of translation, ncRNA-mediated (GO:0045974)	3.02438910
38	peristalsis (GO:0030432)	2.98799384
39	gamma-aminobutyric acid transport (GO:0015812)	2.97931868
40	tryptophan metabolic process (GO:0006568)	2.96733949
41	behavioral response to ethanol (GO:0048149)	2.94967418
42	regulation of action potential (GO:0098900)	2.92787016
43	sulfation (GO:0051923)	2.89189475
44	protein polyglutamylation (GO:0018095)	2.88384002
45	cellular response to ATP (GO:0071318)	2.87726318
46	amino acid salvage (GO:0043102)	2.85504024
47	L-methionine salvage (GO:0071267)	2.85504024
48	L-methionine biosynthetic process (GO:0071265)	2.85504024
49	postsynaptic membrane organization (GO:0001941)	2.85499702
50	rRNA catabolic process (GO:0016075)	2.85467865
51	regulation of meiosis I (GO:0060631)	2.85250852
52	indole-containing compound metabolic process (GO:0042430)	2.84638170
53	cornea development in camera-type eye (GO:0061303)	2.84170123
54	cellular biogenic amine catabolic process (GO:0042402)	2.80518367
55	amine catabolic process (GO:0009310)	2.80518367
56	serotonin metabolic process (GO:0042428)	2.80252735
57	ketone body metabolic process (GO:1902224)	2.78493310
58	nonmotile primary cilium assembly (GO:0035058)	2.75316599
59	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.75011248
60	epithelial cilium movement (GO:0003351)	2.74914565
61	water-soluble vitamin biosynthetic process (GO:0042364)	2.73787836
62	regulation of neurotransmitter uptake (GO:0051580)	2.73476023
63	synaptic transmission, cholinergic (GO:0007271)	2.71668844
64	regulation of mesoderm development (GO:2000380)	2.69064972
65	axoneme assembly (GO:0035082)	2.67444129
66	spinal cord motor neuron differentiation (GO:0021522)	2.65283535
67	ubiquinone biosynthetic process (GO:0006744)	2.62114314
68	rhodopsin mediated signaling pathway (GO:0016056)	2.60267338
69	multicellular organism reproduction (GO:0032504)	2.59864612
70	centriole replication (GO:0007099)	2.59738829
71	fucosylation (GO:0036065)	2.58935121
72	positive regulation of fatty acid transport (GO:2000193)	2.58824492
73	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.58568120
74	endoderm formation (GO:0001706)	2.56660391
75	membrane depolarization during action potential (GO:0086010)	2.55635820
76	NADH dehydrogenase complex assembly (GO:0010257)	2.55137382
77	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.55137382
78	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.55137382
79	cardiovascular system development (GO:0072358)	2.54451098
80	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.53989695
81	DNA methylation involved in gamete generation (GO:0043046)	2.52850791
82	action potential (GO:0001508)	2.52339701
83	positive regulation of action potential (GO:0045760)	2.51639761
84	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.51556277
85	retinal cone cell development (GO:0046549)	2.51111909
86	presynaptic membrane assembly (GO:0097105)	2.50493525
87	positive regulation of meiosis (GO:0045836)	2.49368662
88	cellular response to sterol (GO:0036315)	2.48726788
89	renal tubule morphogenesis (GO:0061333)	2.48566625
90	regulation of gene silencing by RNA (GO:0060966)	2.48227178
91	regulation of posttranscriptional gene silencing (GO:0060147)	2.48227178
92	regulation of gene silencing by miRNA (GO:0060964)	2.48227178
93	startle response (GO:0001964)	2.47608316
94	cilium morphogenesis (GO:0060271)	2.46482866
95	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.45557496
96	cellular response to cholesterol (GO:0071397)	2.44863334
97	regulation of hippo signaling (GO:0035330)	2.44610864
98	ubiquinone metabolic process (GO:0006743)	2.43569802
99	cilium organization (GO:0044782)	2.42699643
100	regulation of microtubule-based movement (GO:0060632)	2.41197131

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.15743178
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.92223174
3	VDR_22108803_ChIP-Seq_LS180_Human	3.22843804
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.11043246
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.76894145
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.75467471
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.46382878
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26589224
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06729292
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.99034912
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.86642355
12	EWS_26573619_Chip-Seq_HEK293_Human	1.86555141
13	ER_23166858_ChIP-Seq_MCF-7_Human	1.82419797
14	TAF15_26573619_Chip-Seq_HEK293_Human	1.80149560
15	IGF1R_20145208_ChIP-Seq_DFB_Human	1.78348556
16	P300_19829295_ChIP-Seq_ESCs_Human	1.77891018
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.74601450
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72930859
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.72697439
20	REST_21632747_ChIP-Seq_MESCs_Mouse	1.72378936
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.71222504
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.69860773
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.67741714
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.63642067
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.62939596
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.62393687
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62021719
28	FUS_26573619_Chip-Seq_HEK293_Human	1.57953175
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55503486
30	STAT3_23295773_ChIP-Seq_U87_Human	1.54118354
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.52588527
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.51831099
33	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50484426
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.49727597
35	AR_21572438_ChIP-Seq_LNCaP_Human	1.49614566
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49262634
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.49262634
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.48173226
39	AR_25329375_ChIP-Seq_VCAP_Human	1.47131729
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45604911
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44504960
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.43988092
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43629209
44	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43252162
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.42840335
46	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41178146
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.41002058
48	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.40406135
49	TCF4_23295773_ChIP-Seq_U87_Human	1.40275645
50	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.39949237
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38200646
52	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.36459901
53	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.34435781
54	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.34300643
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31817028
56	RNF2_27304074_Chip-Seq_NSC_Mouse	1.31587106
57	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.29795260
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28778725
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28778725
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28493890
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27101231
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.27101231
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.26498874
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23927037
65	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.23458667
66	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.22380835
67	HOXB7_26014856_ChIP-Seq_BT474_Human	1.20039580
68	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.19859191
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19534228
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19534228
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18384847
72	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.17309641
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17050076
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.16037776
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14409384
76	DROSHA_22980978_ChIP-Seq_HELA_Human	1.14043063
77	NCOR_22424771_ChIP-Seq_293T_Human	1.14032433
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13713117
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12827938
80	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09431032
81	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.08954362
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07553710
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06735598
84	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06645682
85	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.06628579
86	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.06624984
87	AR_20517297_ChIP-Seq_VCAP_Human	1.06516727
88	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.06496363
89	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.04560296
90	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03878219
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02975489
92	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01512615
93	* ERA_21632823_ChIP-Seq_H3396_Human	1.00784108
94	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99591914
95	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.98795585
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97637011
97	MYC_19829295_ChIP-Seq_ESCs_Human	0.97318038
98	TAF2_19829295_ChIP-Seq_ESCs_Human	0.96490714
99	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.96379733
100	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.95851020

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004885_abnormal_endolymph	3.34667808
2	MP0000569_abnormal_digit_pigmentation	2.71580675
3	MP0003195_calcinosis	2.69346965
4	MP0001968_abnormal_touch/_nociception	2.52970149
5	MP0003136_yellow_coat_color	2.43738126
6	MP0005551_abnormal_eye_electrophysiolog	2.37126794
7	MP0008877_abnormal_DNA_methylation	2.36619786
8	MP0001986_abnormal_taste_sensitivity	2.35170214
9	MP0002102_abnormal_ear_morphology	2.24177801
10	MP0002735_abnormal_chemical_nociception	2.17386459
11	MP0004742_abnormal_vestibular_system	2.17056843
12	MP0001485_abnormal_pinna_reflex	2.16264826
13	MP0002736_abnormal_nociception_after	2.13587748
14	MP0003646_muscle_fatigue	2.12800790
15	MP0009745_abnormal_behavioral_response	2.05120685
16	MP0009046_muscle_twitch	2.01895212
17	MP0008872_abnormal_physiological_respon	2.00483614
18	MP0003283_abnormal_digestive_organ	1.91393034
19	MP0004133_heterotaxia	1.90776575
20	MP0006292_abnormal_olfactory_placode	1.89853564
21	MP0003878_abnormal_ear_physiology	1.86662569
22	MP0005377_hearing/vestibular/ear_phenot	1.86662569
23	MP0003880_abnormal_central_pattern	1.83523661
24	MP0002638_abnormal_pupillary_reflex	1.81000384
25	MP0004142_abnormal_muscle_tone	1.80745988
26	MP0008875_abnormal_xenobiotic_pharmacok	1.80173461
27	MP0002876_abnormal_thyroid_physiology	1.74569714
28	MP0001486_abnormal_startle_reflex	1.73116157
29	MP0004043_abnormal_pH_regulation	1.72258346
30	MP0002653_abnormal_ependyma_morphology	1.71998429
31	MP0006072_abnormal_retinal_apoptosis	1.71235820
32	MP0004147_increased_porphyrin_level	1.69610393
33	MP0002272_abnormal_nervous_system	1.67663593
34	MP0005253_abnormal_eye_physiology	1.66783450
35	MP0002837_dystrophic_cardiac_calcinosis	1.64051585
36	MP0000427_abnormal_hair_cycle	1.56529326
37	MP0002572_abnormal_emotion/affect_behav	1.52377972
38	MP0000631_abnormal_neuroendocrine_gland	1.50549619
39	MP0002938_white_spotting	1.47219530
40	MP0002064_seizures	1.46817501
41	MP0005645_abnormal_hypothalamus_physiol	1.46446251
42	MP0003011_delayed_dark_adaptation	1.43256646
43	MP0001501_abnormal_sleep_pattern	1.42492960
44	MP0006276_abnormal_autonomic_nervous	1.42175340
45	MP0003787_abnormal_imprinting	1.42030903
46	MP0002557_abnormal_social/conspecific_i	1.41432773
47	MP0005646_abnormal_pituitary_gland	1.40469658
48	MP0004145_abnormal_muscle_electrophysio	1.39202732
49	MP0003890_abnormal_embryonic-extraembry	1.37455364
50	MP0002063_abnormal_learning/memory/cond	1.37407601
51	MP0002733_abnormal_thermal_nociception	1.34837197
52	MP0002067_abnormal_sensory_capabilities	1.32113684
53	MP0003635_abnormal_synaptic_transmissio	1.31777519
54	MP0001970_abnormal_pain_threshold	1.30670426
55	MP0005174_abnormal_tail_pigmentation	1.29046063
56	MP0002234_abnormal_pharynx_morphology	1.18750609
57	MP0000026_abnormal_inner_ear	1.18314948
58	MP0002095_abnormal_skin_pigmentation	1.17665407
59	MP0005386_behavior/neurological_phenoty	1.17575841
60	MP0004924_abnormal_behavior	1.17575841
61	MP0001440_abnormal_grooming_behavior	1.17130229
62	MP0004215_abnormal_myocardial_fiber	1.16248500
63	MP0005195_abnormal_posterior_eye	1.13497636
64	MP0002734_abnormal_mechanical_nocicepti	1.11652440
65	MP0002928_abnormal_bile_duct	1.08051280
66	MP0001502_abnormal_circadian_rhythm	1.06754731
67	MP0001905_abnormal_dopamine_level	1.04841485
68	MP0002254_reproductive_system_inflammat	1.04324386
69	MP0000778_abnormal_nervous_system	1.03072544
70	MP0005084_abnormal_gallbladder_morpholo	1.03056825
71	MP0002277_abnormal_respiratory_mucosa	1.01390510
72	MP0008995_early_reproductive_senescence	1.01288974
73	MP0005389_reproductive_system_phenotype	1.00476810
74	MP0003119_abnormal_digestive_system	0.99957422
75	MP0005423_abnormal_somatic_nervous	0.99733539
76	MP0000230_abnormal_systemic_arterial	0.99230977
77	MP0002160_abnormal_reproductive_system	0.97995555
78	MP0003718_maternal_effect	0.96371052
79	MP0000049_abnormal_middle_ear	0.96346434
80	MP0002752_abnormal_somatic_nervous	0.95245142
81	MP0003137_abnormal_impulse_conducting	0.94285957
82	MP0001984_abnormal_olfaction	0.94089674
83	MP0004130_abnormal_muscle_cell	0.93576069
84	MP0001963_abnormal_hearing_physiology	0.90791375
85	MP0005167_abnormal_blood-brain_barrier	0.90450103
86	MP0000383_abnormal_hair_follicle	0.86412021
87	MP0000015_abnormal_ear_pigmentation	0.86334783
88	MP0000372_irregular_coat_pigmentation	0.86315677
89	MP0001919_abnormal_reproductive_system	0.85902712
90	MP0000647_abnormal_sebaceous_gland	0.84671026
91	MP0008775_abnormal_heart_ventricle	0.82776795
92	MP0001324_abnormal_eye_pigmentation	0.81949968
93	MP0002282_abnormal_trachea_morphology	0.78248647
94	MP0003698_abnormal_male_reproductive	0.78226289
95	MP0001293_anophthalmia	0.76655256
96	MP0002882_abnormal_neuron_morphology	0.76144728
97	MP0002229_neurodegeneration	0.75681200
98	MP0008961_abnormal_basal_metabolism	0.74779281
99	MP0005187_abnormal_penis_morphology	0.74750634
100	MP0005391_vision/eye_phenotype	0.71958647

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.51668588
2	Abnormality of midbrain morphology (HP:0002418)	4.40243495
3	Molar tooth sign on MRI (HP:0002419)	4.40243495
4	Congenital stationary night blindness (HP:0007642)	4.26435992
5	True hermaphroditism (HP:0010459)	4.23304943
6	Pancreatic fibrosis (HP:0100732)	4.11976047
7	Birth length less than 3rd percentile (HP:0003561)	3.69503192
8	Hyperventilation (HP:0002883)	3.67955696
9	Nephronophthisis (HP:0000090)	3.60035609
10	Abnormality of the renal cortex (HP:0011035)	3.48406380
11	Abnormality of the renal medulla (HP:0100957)	3.44861929
12	Hyperalaninemia (HP:0003348)	3.19851819
13	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.19851819
14	Abnormality of alanine metabolism (HP:0010916)	3.19851819
15	Type II lissencephaly (HP:0007260)	3.17917631
16	Pendular nystagmus (HP:0012043)	2.98662383
17	Large for gestational age (HP:0001520)	2.93302738
18	Attenuation of retinal blood vessels (HP:0007843)	2.90809926
19	Cystic liver disease (HP:0006706)	2.87867586
20	Lissencephaly (HP:0001339)	2.77063255
21	Medial flaring of the eyebrow (HP:0010747)	2.73461464
22	Nephrogenic diabetes insipidus (HP:0009806)	2.73013588
23	Patellar aplasia (HP:0006443)	2.72714596
24	Protruding tongue (HP:0010808)	2.71041720
25	Furrowed tongue (HP:0000221)	2.69612851
26	Inability to walk (HP:0002540)	2.65039646
27	Abolished electroretinogram (ERG) (HP:0000550)	2.63968825
28	Aplasia/Hypoplasia of the patella (HP:0006498)	2.58026703
29	Sclerocornea (HP:0000647)	2.52993754
30	Congenital, generalized hypertrichosis (HP:0004540)	2.52980432
31	Tubular atrophy (HP:0000092)	2.50079076
32	Increased corneal curvature (HP:0100692)	2.41973853
33	Keratoconus (HP:0000563)	2.41973853
34	Genetic anticipation (HP:0003743)	2.40844588
35	Progressive cerebellar ataxia (HP:0002073)	2.36309358
36	Gait imbalance (HP:0002141)	2.35996658
37	Broad-based gait (HP:0002136)	2.33844661
38	Chorioretinal atrophy (HP:0000533)	2.32513542
39	Chronic hepatic failure (HP:0100626)	2.28201209
40	Congenital primary aphakia (HP:0007707)	2.24291875
41	Hypoplastic ischia (HP:0003175)	2.22679988
42	Anencephaly (HP:0002323)	2.22437593
43	Abnormal rod and cone electroretinograms (HP:0008323)	2.21235148
44	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.17213985
45	Absent/shortened dynein arms (HP:0200106)	2.17213985
46	Progressive inability to walk (HP:0002505)	2.16826479
47	Male pseudohermaphroditism (HP:0000037)	2.16306525
48	Oligodactyly (hands) (HP:0001180)	2.16160130
49	Abnormal drinking behavior (HP:0030082)	2.15042708
50	Polydipsia (HP:0001959)	2.15042708
51	Severe muscular hypotonia (HP:0006829)	2.14498659
52	Focal motor seizures (HP:0011153)	2.13850936
53	Polyuria (HP:0000103)	2.13687070
54	Concave nail (HP:0001598)	2.12990441
55	Congenital sensorineural hearing impairment (HP:0008527)	2.12170507
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10078901
57	Cerebellar dysplasia (HP:0007033)	2.09753438
58	Decreased circulating renin level (HP:0003351)	2.08444427
59	Abnormal respiratory epithelium morphology (HP:0012253)	2.08113940
60	Abnormal respiratory motile cilium morphology (HP:0005938)	2.08113940
61	Fair hair (HP:0002286)	2.07708556
62	Renal cortical cysts (HP:0000803)	2.05526646
63	Clumsiness (HP:0002312)	2.03334155
64	Small hand (HP:0200055)	2.02941017
65	Congenital hepatic fibrosis (HP:0002612)	2.02931919
66	Metabolic alkalosis (HP:0200114)	2.02659952
67	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.99413710
68	Breast hypoplasia (HP:0003187)	1.99269099
69	Decreased central vision (HP:0007663)	1.97600644
70	Gaze-evoked nystagmus (HP:0000640)	1.97103300
71	Bile duct proliferation (HP:0001408)	1.97079715
72	Abnormal biliary tract physiology (HP:0012439)	1.97079715
73	Abnormality of the pons (HP:0007361)	1.92963691
74	Widely spaced teeth (HP:0000687)	1.90860779
75	Hypoplasia of the pons (HP:0012110)	1.87466990
76	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.86114501
77	Pachygyria (HP:0001302)	1.83714842
78	Abnormality of the ischium (HP:0003174)	1.82945994
79	11 pairs of ribs (HP:0000878)	1.81625344
80	Hemiparesis (HP:0001269)	1.80032239
81	Absent speech (HP:0001344)	1.78924742
82	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.78445101
83	Tubulointerstitial fibrosis (HP:0005576)	1.78250545
84	Genital tract atresia (HP:0001827)	1.77970586
85	Tachypnea (HP:0002789)	1.77470933
86	Vaginal atresia (HP:0000148)	1.76955619
87	Anophthalmia (HP:0000528)	1.75740952
88	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.75560882
89	Bilateral microphthalmos (HP:0007633)	1.75428652
90	Febrile seizures (HP:0002373)	1.75274644
91	Optic nerve hypoplasia (HP:0000609)	1.74400614
92	Arthropathy (HP:0003040)	1.73901361
93	Postaxial foot polydactyly (HP:0001830)	1.72998266
94	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.72909304
95	Retinal dysplasia (HP:0007973)	1.72413877
96	Abnormal ciliary motility (HP:0012262)	1.70768698
97	Hypoplastic iliac wings (HP:0002866)	1.70065718
98	Rib fusion (HP:0000902)	1.69807024
99	Abnormal urine output (HP:0012590)	1.67932939
100	Stomach cancer (HP:0012126)	1.67502655

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.68197244
2	ADRBK2	4.10850387
3	BMPR1B	3.88435008
4	ACVR1B	3.64800417
5	INSRR	3.32213757
6	NUAK1	2.70226312
7	CASK	2.56448716
8	ZAK	2.53239719
9	PNCK	2.52062847
10	GRK1	2.42389440
11	WNK4	2.42296299
12	TLK1	2.39953998
13	WNK3	2.28911950
14	DAPK2	2.05117053
15	PINK1	1.92230819
16	MAPK13	1.75248402
17	TGFBR1	1.67791094
18	TAOK3	1.67484833
19	MARK1	1.64256743
20	MAPK15	1.60899391
21	MAP4K2	1.53368165
22	NTRK3	1.40910446
23	ADRBK1	1.31950807
24	OXSR1	1.31242977
25	MAP3K4	1.25334675
26	MKNK2	1.20703927
27	PAK3	1.16203350
28	TXK	1.09637612
29	TIE1	1.06561879
30	TNIK	1.03638912
31	MAP2K6	1.02099517
32	LATS1	1.01252437
33	STK39	1.00595366
34	CSNK1G1	0.96437517
35	CAMKK2	0.92878676
36	NTRK2	0.91572659
37	PRKCG	0.85463206
38	WNK1	0.83713547
39	SIK2	0.82760908
40	DYRK2	0.80511553
41	MAP2K7	0.79770313
42	CDK3	0.79093890
43	WEE1	0.78762286
44	MUSK	0.77938228
45	PTK2B	0.77128739
46	NLK	0.71991886
47	STK38L	0.71897168
48	PRKCE	0.69317504
49	PHKG2	0.67402926
50	PHKG1	0.67402926
51	PIK3CA	0.66108268
52	CAMK2A	0.62294608
53	CSNK1G2	0.62172540
54	CAMK1	0.60168473
55	CAMK1G	0.58796911
56	VRK1	0.58280788
57	MAP2K2	0.57803114
58	BCKDK	0.57759793
59	PRKCQ	0.54665051
60	SGK2	0.52813349
61	STK3	0.51311768
62	NEK2	0.50956640
63	CSNK1G3	0.50124514
64	PKN1	0.49211437
65	IKBKB	0.49112959
66	RPS6KA5	0.48210628
67	RPS6KA6	0.47786509
68	CAMK1D	0.46380417
69	MAP2K1	0.45805600
70	AKT3	0.45551798
71	CHUK	0.43056565
72	STK11	0.42118579
73	CSNK1A1L	0.42081893
74	IRAK1	0.41494676
75	TRIM28	0.41348669
76	OBSCN	0.40576199
77	PRKACA	0.40328924
78	EPHB2	0.38432664
79	BRSK2	0.37911684
80	KIT	0.37876714
81	CAMK4	0.37424355
82	MKNK1	0.37227869
83	SGK223	0.36745100
84	SGK494	0.36745100
85	CAMKK1	0.36470133
86	CSNK1A1	0.36447100
87	MAPKAPK3	0.35130652
88	PRKCI	0.34322359
89	EPHA3	0.34265693
90	CDK19	0.33547928
91	TEC	0.33370832
92	ERBB2	0.31870099
93	PLK4	0.31744627
94	TSSK6	0.31627822
95	MAPK12	0.30200033
96	PRKCZ	0.30139176
97	MAPKAPK5	0.29909351
98	PLK2	0.29725865
99	FLT3	0.28304542
100	PRKG1	0.28111317

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.57726377
2	Phototransduction_Homo sapiens_hsa04744	3.02212118
3	Selenocompound metabolism_Homo sapiens_hsa00450	2.92333181
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.82335614
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.81145266
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.67870026
7	Nicotine addiction_Homo sapiens_hsa05033	2.49564738
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.45745489
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.25384518
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.22678037
11	Butanoate metabolism_Homo sapiens_hsa00650	2.21806420
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.06964963
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.06169022
14	Ether lipid metabolism_Homo sapiens_hsa00565	2.00397326
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.97015521
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.96598510
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.72733002
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.66524337
19	Taste transduction_Homo sapiens_hsa04742	1.62494273
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.55818327
21	Morphine addiction_Homo sapiens_hsa05032	1.51705018
22	Homologous recombination_Homo sapiens_hsa03440	1.50652716
23	Caffeine metabolism_Homo sapiens_hsa00232	1.47754358
24	ABC transporters_Homo sapiens_hsa02010	1.37694277
25	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.37530601
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.31962594
27	Olfactory transduction_Homo sapiens_hsa04740	1.30999129
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.27544280
29	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.18025651
30	Circadian entrainment_Homo sapiens_hsa04713	1.17613225
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15691885
32	GABAergic synapse_Homo sapiens_hsa04727	1.15538827
33	Insulin secretion_Homo sapiens_hsa04911	1.15406123
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.14361338
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.12607429
36	Glutamatergic synapse_Homo sapiens_hsa04724	1.10963485
37	Basal transcription factors_Homo sapiens_hsa03022	1.10953155
38	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.10762362
39	Serotonergic synapse_Homo sapiens_hsa04726	1.08928347
40	Protein export_Homo sapiens_hsa03060	1.08888416
41	Parkinsons disease_Homo sapiens_hsa05012	1.08789734
42	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.06322163
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.05955952
44	One carbon pool by folate_Homo sapiens_hsa00670	1.04065455
45	Cardiac muscle contraction_Homo sapiens_hsa04260	1.02173146
46	RNA polymerase_Homo sapiens_hsa03020	1.01775441
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.00291085
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.98835473
49	Fat digestion and absorption_Homo sapiens_hsa04975	0.97275717
50	Retinol metabolism_Homo sapiens_hsa00830	0.92941989
51	Histidine metabolism_Homo sapiens_hsa00340	0.90470891
52	Peroxisome_Homo sapiens_hsa04146	0.89817769
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.86730373
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84497498
55	Propanoate metabolism_Homo sapiens_hsa00640	0.83672831
56	RNA degradation_Homo sapiens_hsa03018	0.82380632
57	Calcium signaling pathway_Homo sapiens_hsa04020	0.82254113
58	Regulation of autophagy_Homo sapiens_hsa04140	0.79570427
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75382301
60	Cocaine addiction_Homo sapiens_hsa05030	0.74354946
61	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.74325534
62	Alzheimers disease_Homo sapiens_hsa05010	0.72220178
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71441681
64	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.71245845
65	Huntingtons disease_Homo sapiens_hsa05016	0.71080638
66	Mineral absorption_Homo sapiens_hsa04978	0.68120421
67	Dopaminergic synapse_Homo sapiens_hsa04728	0.67834666
68	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.65903230
69	Sulfur relay system_Homo sapiens_hsa04122	0.65316042
70	Salivary secretion_Homo sapiens_hsa04970	0.63349738
71	Long-term depression_Homo sapiens_hsa04730	0.62214431
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59068983
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58010857
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.57385333
75	Cholinergic synapse_Homo sapiens_hsa04725	0.57215986
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.57057237
77	Amphetamine addiction_Homo sapiens_hsa05031	0.55554877
78	cAMP signaling pathway_Homo sapiens_hsa04024	0.53429982
79	Basal cell carcinoma_Homo sapiens_hsa05217	0.52162435
80	Asthma_Homo sapiens_hsa05310	0.50042535
81	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47701977
82	Sulfur metabolism_Homo sapiens_hsa00920	0.46327101
83	Gastric acid secretion_Homo sapiens_hsa04971	0.45537227
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45451067
85	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.44078558
86	Metabolic pathways_Homo sapiens_hsa01100	0.43014355
87	Circadian rhythm_Homo sapiens_hsa04710	0.42910256
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.42892797
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.42346969
90	Steroid biosynthesis_Homo sapiens_hsa00100	0.40657599
91	Purine metabolism_Homo sapiens_hsa00230	0.40501819
92	Collecting duct acid secretion_Homo sapiens_hsa04966	0.40441697
93	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.37194288
94	Axon guidance_Homo sapiens_hsa04360	0.37097397
95	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.36457397
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36211950
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.34604958
98	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.33581632
99	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31894768
100	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.31816526

ZNF554

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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