ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.23396569
2	behavioral response to nicotine (GO:0035095)	4.18984514
3	piRNA metabolic process (GO:0034587)	4.08123215
4	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.72621539
5	fucose catabolic process (GO:0019317)	3.66279349
6	L-fucose metabolic process (GO:0042354)	3.66279349
7	L-fucose catabolic process (GO:0042355)	3.66279349
8	pyrimidine nucleobase catabolic process (GO:0006208)	3.65780367
9	presynaptic membrane assembly (GO:0097105)	3.51923147
10	establishment of protein localization to Golgi (GO:0072600)	3.32645331
11	neural tube formation (GO:0001841)	3.31482795
12	intraciliary transport (GO:0042073)	3.27287964
13	epithelial cilium movement (GO:0003351)	3.27056459
14	behavioral response to ethanol (GO:0048149)	3.26328103
15	neuron cell-cell adhesion (GO:0007158)	3.16260112
16	nucleobase catabolic process (GO:0046113)	3.13820199
17	gamma-aminobutyric acid transport (GO:0015812)	3.13190025
18	DNA methylation involved in gamete generation (GO:0043046)	3.10121746
19	protein targeting to Golgi (GO:0000042)	3.10071662
20	platelet dense granule organization (GO:0060155)	3.08539801
21	protein polyglutamylation (GO:0018095)	3.07078268
22	postsynaptic membrane organization (GO:0001941)	3.07038282
23	cilium organization (GO:0044782)	3.06117608
24	nonmotile primary cilium assembly (GO:0035058)	3.05037707
25	positive regulation of mitochondrial fission (GO:0090141)	3.03320049
26	C4-dicarboxylate transport (GO:0015740)	3.02817588
27	protein localization to cilium (GO:0061512)	3.00677974
28	axoneme assembly (GO:0035082)	2.99991061
29	retinal cone cell development (GO:0046549)	2.99642145
30	cilium assembly (GO:0042384)	2.99590462
31	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.99441889
32	regulation of cilium movement (GO:0003352)	2.98884848
33	presynaptic membrane organization (GO:0097090)	2.97221886
34	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.94208386
35	cilium or flagellum-dependent cell motility (GO:0001539)	2.92676315
36	prenylation (GO:0097354)	2.91504197
37	protein prenylation (GO:0018342)	2.91504197
38	regulation of meiosis I (GO:0060631)	2.91200521
39	cilium morphogenesis (GO:0060271)	2.90205562
40	protein K11-linked deubiquitination (GO:0035871)	2.89006733
41	glycerophospholipid catabolic process (GO:0046475)	2.87105026
42	indolalkylamine metabolic process (GO:0006586)	2.86765345
43	kynurenine metabolic process (GO:0070189)	2.84456164
44	water-soluble vitamin biosynthetic process (GO:0042364)	2.83460542
45	regulation of action potential (GO:0098900)	2.81836641
46	cilium movement (GO:0003341)	2.80910520
47	neuronal action potential (GO:0019228)	2.80239349
48	glycosphingolipid biosynthetic process (GO:0006688)	2.76712367
49	photoreceptor cell maintenance (GO:0045494)	2.75583874
50	tryptophan catabolic process (GO:0006569)	2.73356211
51	indole-containing compound catabolic process (GO:0042436)	2.73356211
52	indolalkylamine catabolic process (GO:0046218)	2.73356211
53	detection of light stimulus involved in visual perception (GO:0050908)	2.72601116
54	detection of light stimulus involved in sensory perception (GO:0050962)	2.72601116
55	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.71073791
56	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.70155100
57	male meiosis (GO:0007140)	2.70122507
58	limb bud formation (GO:0060174)	2.65814722
59	negative regulation of mast cell activation (GO:0033004)	2.65345595
60	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.63823665
61	regulation of translation, ncRNA-mediated (GO:0045974)	2.63823665
62	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.63823665
63	protein localization to Golgi apparatus (GO:0034067)	2.62802369
64	multicellular organism reproduction (GO:0032504)	2.61350979
65	adaptation of signaling pathway (GO:0023058)	2.58343393
66	regulation of hexokinase activity (GO:1903299)	2.58259261
67	regulation of glucokinase activity (GO:0033131)	2.58259261
68	centriole replication (GO:0007099)	2.58246449
69	DNA double-strand break processing (GO:0000729)	2.57160667
70	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.53610456
71	regulation of sarcomere organization (GO:0060297)	2.49388033
72	synaptic transmission, cholinergic (GO:0007271)	2.48921523
73	tryptophan metabolic process (GO:0006568)	2.48836145
74	rRNA catabolic process (GO:0016075)	2.48620036
75	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.48315027
76	preassembly of GPI anchor in ER membrane (GO:0016254)	2.47507574
77	inner ear receptor stereocilium organization (GO:0060122)	2.46480212
78	startle response (GO:0001964)	2.45667434
79	sperm motility (GO:0030317)	2.45567700
80	cellular component assembly involved in morphogenesis (GO:0010927)	2.45226688
81	neuronal action potential propagation (GO:0019227)	2.44518085
82	acrosome assembly (GO:0001675)	2.43671058
83	anterograde synaptic vesicle transport (GO:0048490)	2.43570780
84	DNA deamination (GO:0045006)	2.41942898
85	reflex (GO:0060004)	2.41051788
86	protein localization to synapse (GO:0035418)	2.39931898
87	replication fork processing (GO:0031297)	2.38835099
88	respiratory chain complex IV assembly (GO:0008535)	2.38800247
89	mannosylation (GO:0097502)	2.38223578
90	single strand break repair (GO:0000012)	2.37229373
91	cornea development in camera-type eye (GO:0061303)	2.36900451
92	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.36376081
93	acrosome reaction (GO:0007340)	2.36265926
94	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.35663728
95	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.35663728
96	inositol phosphate catabolic process (GO:0071545)	2.33024859
97	positive regulation of action potential (GO:0045760)	2.32237574
98	nucleotide transmembrane transport (GO:1901679)	2.30043418
99	regulation of telomere maintenance (GO:0032204)	2.28843278
100	regulation of acrosome reaction (GO:0060046)	2.28603514

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.64689760
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.28191872
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.06789920
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.95393016
5	VDR_22108803_ChIP-Seq_LS180_Human	2.91650118
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.84508766
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.64891263
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.49450487
9	FUS_26573619_Chip-Seq_HEK293_Human	2.43355678
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.40331125
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.35312125
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.34905178
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.30550987
14	EWS_26573619_Chip-Seq_HEK293_Human	2.27347089
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.25338438
16	P300_19829295_ChIP-Seq_ESCs_Human	2.24414773
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02321173
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.94201017
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.90236079
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.88324808
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.87676351
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.86640971
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.78250698
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.75756732
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.72943359
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.71616019
27	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.71521848
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.70812577
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.67494911
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.67494911
31	STAT3_23295773_ChIP-Seq_U87_Human	1.66477171
32	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.64160365
33	* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.64096910
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.62076757
35	* TCF4_23295773_ChIP-Seq_U87_Human	1.55850985
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55421595
37	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.55015830
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54466611
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.54268295
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.51719227
41	AR_25329375_ChIP-Seq_VCAP_Human	1.51679753
42	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.51580844
43	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.51494287
44	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49407121
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.48392908
46	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.47561659
47	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45612190
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.42069614
49	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.39962654
50	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39962654
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39450970
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.38683451
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38560922
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38408325
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.37015756
56	RNF2_27304074_Chip-Seq_NSC_Mouse	1.34855221
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34602474
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32680122
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32680122
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31942878
61	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.28636524
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27767982
63	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.27742011
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26574407
65	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.26391273
66	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25957809
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.25807385
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25228539
69	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.21472764
70	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.19473040
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18252506
72	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17830545
73	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.15937613
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15386882
75	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14301150
76	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.14058432
77	ELK1_19687146_ChIP-ChIP_HELA_Human	1.13932580
78	REST_21632747_ChIP-Seq_MESCs_Mouse	1.13578030
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13386410
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12554471
81	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.11857743
82	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.10075798
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09910060
84	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.08886965
85	CDX2_22108803_ChIP-Seq_LS180_Human	1.08762772
86	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.08249910
87	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.06321090
88	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.04300250
89	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.02748303
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02684094
91	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.02592725
92	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02173340
93	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.01379851
94	AR_21572438_ChIP-Seq_LNCaP_Human	1.01065889
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.00255238
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99159835
97	MYC_18940864_ChIP-ChIP_HL60_Human	0.99123418
98	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.97934867
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97899964
100	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97899964

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.41633949
2	MP0008877_abnormal_DNA_methylation	3.41019001
3	MP0003787_abnormal_imprinting	2.90812484
4	MP0003880_abnormal_central_pattern	2.37012329
5	MP0001968_abnormal_touch/_nociception	2.25530100
6	MP0000569_abnormal_digit_pigmentation	2.21239894
7	MP0006276_abnormal_autonomic_nervous	2.20951655
8	MP0005551_abnormal_eye_electrophysiolog	2.19605903
9	MP0002736_abnormal_nociception_after	2.15445552
10	MP0003195_calcinosis	2.14823993
11	MP0001984_abnormal_olfaction	2.14408349
12	MP0009046_muscle_twitch	2.09828475
13	MP0005645_abnormal_hypothalamus_physiol	2.09577496
14	MP0006072_abnormal_retinal_apoptosis	1.99977640
15	MP0006292_abnormal_olfactory_placode	1.98828917
16	MP0005253_abnormal_eye_physiology	1.84846831
17	MP0001529_abnormal_vocalization	1.77699523
18	MP0003121_genomic_imprinting	1.74129128
19	MP0002272_abnormal_nervous_system	1.71420541
20	MP0001986_abnormal_taste_sensitivity	1.69760637
21	MP0003890_abnormal_embryonic-extraembry	1.68801774
22	MP0003718_maternal_effect	1.68790527
23	MP0005646_abnormal_pituitary_gland	1.67157860
24	MP0002837_dystrophic_cardiac_calcinosis	1.66888940
25	MP0009745_abnormal_behavioral_response	1.66849133
26	MP0002638_abnormal_pupillary_reflex	1.65449070
27	MP0003122_maternal_imprinting	1.60481180
28	MP0001486_abnormal_startle_reflex	1.53741463
29	MP0004142_abnormal_muscle_tone	1.53430428
30	MP0008789_abnormal_olfactory_epithelium	1.52315759
31	MP0000631_abnormal_neuroendocrine_gland	1.50618210
32	MP0000372_irregular_coat_pigmentation	1.48805880
33	MP0000427_abnormal_hair_cycle	1.45868135
34	MP0002938_white_spotting	1.44472406
35	MP0002735_abnormal_chemical_nociception	1.43308184
36	MP0004133_heterotaxia	1.40947981
37	MP0000778_abnormal_nervous_system	1.39193730
38	MP0001501_abnormal_sleep_pattern	1.32780700
39	MP0005499_abnormal_olfactory_system	1.31693557
40	MP0005394_taste/olfaction_phenotype	1.31693557
41	MP0002572_abnormal_emotion/affect_behav	1.31516208
42	MP0004215_abnormal_myocardial_fiber	1.30185644
43	MP0008872_abnormal_physiological_respon	1.29593201
44	MP0002928_abnormal_bile_duct	1.28742875
45	MP0003635_abnormal_synaptic_transmissio	1.26897237
46	MP0002234_abnormal_pharynx_morphology	1.26134967
47	MP0008058_abnormal_DNA_repair	1.25613243
48	MP0005084_abnormal_gallbladder_morpholo	1.25312356
49	MP0004270_analgesia	1.24569190
50	MP0004924_abnormal_behavior	1.23020777
51	MP0005386_behavior/neurological_phenoty	1.23020777
52	MP0002557_abnormal_social/conspecific_i	1.20568369
53	MP0004145_abnormal_muscle_electrophysio	1.18938511
54	MP0002063_abnormal_learning/memory/cond	1.18675300
55	MP0002160_abnormal_reproductive_system	1.18263536
56	MP0005410_abnormal_fertilization	1.16870973
57	MP0001502_abnormal_circadian_rhythm	1.16694387
58	MP0001970_abnormal_pain_threshold	1.15809383
59	MP0002064_seizures	1.15379963
60	MP0002067_abnormal_sensory_capabilities	1.15375141
61	MP0002734_abnormal_mechanical_nocicepti	1.14459009
62	MP0003011_delayed_dark_adaptation	1.13981308
63	MP0003646_muscle_fatigue	1.13114695
64	MP0004043_abnormal_pH_regulation	1.11582322
65	MP0005423_abnormal_somatic_nervous	1.10218456
66	MP0002733_abnormal_thermal_nociception	1.09406680
67	MP0002751_abnormal_autonomic_nervous	1.08087918
68	MP0001929_abnormal_gametogenesis	1.06361768
69	MP0001485_abnormal_pinna_reflex	1.05686098
70	MP0005174_abnormal_tail_pigmentation	1.04550873
71	MP0003136_yellow_coat_color	1.04467097
72	MP0002876_abnormal_thyroid_physiology	1.04083114
73	MP0010386_abnormal_urinary_bladder	1.01964411
74	MP0003698_abnormal_male_reproductive	0.99792858
75	MP0005187_abnormal_penis_morphology	0.99152319
76	MP0009697_abnormal_copulation	0.98841142
77	MP0005167_abnormal_blood-brain_barrier	0.96087708
78	MP0004885_abnormal_endolymph	0.95955037
79	MP0004147_increased_porphyrin_level	0.95589571
80	MP0008775_abnormal_heart_ventricle	0.93663996
81	MP0004859_abnormal_synaptic_plasticity	0.93108557
82	MP0003119_abnormal_digestive_system	0.92574699
83	MP0005389_reproductive_system_phenotype	0.91865935
84	MP0005379_endocrine/exocrine_gland_phen	0.91525564
85	MP0002752_abnormal_somatic_nervous	0.90765923
86	MP0002184_abnormal_innervation	0.89142372
87	MP0000516_abnormal_urinary_system	0.88840557
88	MP0005367_renal/urinary_system_phenotyp	0.88840557
89	MP0000383_abnormal_hair_follicle	0.88384944
90	MP0000647_abnormal_sebaceous_gland	0.87580620
91	MP0008057_abnormal_DNA_replication	0.86717426
92	MP0002163_abnormal_gland_morphology	0.86620154
93	MP0004085_abnormal_heartbeat	0.86393938
94	MP0001293_anophthalmia	0.82902524
95	MP0005195_abnormal_posterior_eye	0.82800320
96	MP0002229_neurodegeneration	0.82359882
97	MP0002210_abnormal_sex_determination	0.81013263
98	MP0003137_abnormal_impulse_conducting	0.81009568
99	MP0002882_abnormal_neuron_morphology	0.80800082
100	MP0004084_abnormal_cardiac_muscle	0.80513147

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.20274847
2	Pancreatic fibrosis (HP:0100732)	4.08754609
3	Hyperventilation (HP:0002883)	3.83338089
4	Medial flaring of the eyebrow (HP:0010747)	3.75861407
5	True hermaphroditism (HP:0010459)	3.70771659
6	Abnormality of midbrain morphology (HP:0002418)	3.56973417
7	Molar tooth sign on MRI (HP:0002419)	3.56973417
8	Nephronophthisis (HP:0000090)	3.38509705
9	Chronic hepatic failure (HP:0100626)	3.38147378
10	Gait imbalance (HP:0002141)	3.27560747
11	Congenital primary aphakia (HP:0007707)	3.13580563
12	Type II lissencephaly (HP:0007260)	3.09270935
13	Nephrogenic diabetes insipidus (HP:0009806)	3.00968086
14	Abnormality of the renal medulla (HP:0100957)	2.88393713
15	Genital tract atresia (HP:0001827)	2.87304826
16	Abnormality of the labia minora (HP:0012880)	2.80903838
17	Abnormality of the renal cortex (HP:0011035)	2.75919054
18	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.71980117
19	Progressive inability to walk (HP:0002505)	2.68885209
20	Broad-based gait (HP:0002136)	2.68528874
21	Lissencephaly (HP:0001339)	2.67196429
22	Pendular nystagmus (HP:0012043)	2.65041691
23	Vaginal atresia (HP:0000148)	2.64828164
24	Inability to walk (HP:0002540)	2.59743685
25	Abnormal biliary tract physiology (HP:0012439)	2.58789847
26	Bile duct proliferation (HP:0001408)	2.58789847
27	Absent speech (HP:0001344)	2.57499531
28	Drooling (HP:0002307)	2.47902829
29	Congenital stationary night blindness (HP:0007642)	2.46677110
30	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.45280424
31	Gaze-evoked nystagmus (HP:0000640)	2.41205158
32	Pachygyria (HP:0001302)	2.38941660
33	Attenuation of retinal blood vessels (HP:0007843)	2.37856924
34	Cystic liver disease (HP:0006706)	2.37167283
35	Focal motor seizures (HP:0011153)	2.35397116
36	Renal cortical cysts (HP:0000803)	2.32246065
37	Febrile seizures (HP:0002373)	2.29848021
38	Abolished electroretinogram (ERG) (HP:0000550)	2.29671702
39	Short tibia (HP:0005736)	2.29167876
40	Cerebellar dysplasia (HP:0007033)	2.26898971
41	Protruding tongue (HP:0010808)	2.24966142
42	Epileptic encephalopathy (HP:0200134)	2.24757013
43	Postaxial foot polydactyly (HP:0001830)	2.24587355
44	Poor coordination (HP:0002370)	2.24454681
45	Septo-optic dysplasia (HP:0100842)	2.21169708
46	Optic nerve hypoplasia (HP:0000609)	2.21083390
47	Excessive salivation (HP:0003781)	2.20844733
48	Tubular atrophy (HP:0000092)	2.16976455
49	Sclerocornea (HP:0000647)	2.12366570
50	Congenital hepatic fibrosis (HP:0002612)	2.12118977
51	Polyphagia (HP:0002591)	2.11258756
52	Specific learning disability (HP:0001328)	2.10255853
53	Fair hair (HP:0002286)	2.09960201
54	Absent/shortened dynein arms (HP:0200106)	2.08738287
55	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.08738287
56	Hemiparesis (HP:0001269)	2.06742140
57	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.05012262
58	Postaxial hand polydactyly (HP:0001162)	2.03956600
59	Occipital encephalocele (HP:0002085)	2.02609236
60	Increased corneal curvature (HP:0100692)	2.00966506
61	Keratoconus (HP:0000563)	2.00966506
62	Retinal dysplasia (HP:0007973)	1.96907620
63	Polydipsia (HP:0001959)	1.95927968
64	Abnormal drinking behavior (HP:0030082)	1.95927968
65	Tubulointerstitial nephritis (HP:0001970)	1.95754616
66	Abnormal rod and cone electroretinograms (HP:0008323)	1.95046092
67	Widely spaced teeth (HP:0000687)	1.92834394
68	Anencephaly (HP:0002323)	1.91413311
69	Progressive cerebellar ataxia (HP:0002073)	1.90824689
70	Supernumerary spleens (HP:0009799)	1.90692194
71	Intestinal atresia (HP:0011100)	1.88122124
72	Focal seizures (HP:0007359)	1.87738545
73	Stomach cancer (HP:0012126)	1.87351523
74	Narrow forehead (HP:0000341)	1.86052916
75	Abnormal ciliary motility (HP:0012262)	1.83711005
76	Furrowed tongue (HP:0000221)	1.81785462
77	Abnormality of macular pigmentation (HP:0008002)	1.78035763
78	Abnormal respiratory motile cilium morphology (HP:0005938)	1.77473217
79	Abnormal respiratory epithelium morphology (HP:0012253)	1.77473217
80	Bony spicule pigmentary retinopathy (HP:0007737)	1.76936271
81	Male pseudohermaphroditism (HP:0000037)	1.75511654
82	Dialeptic seizures (HP:0011146)	1.75288011
83	Left ventricular hypertrophy (HP:0001712)	1.72923770
84	Astigmatism (HP:0000483)	1.72384493
85	Dandy-Walker malformation (HP:0001305)	1.71467808
86	Calf muscle hypertrophy (HP:0008981)	1.69999514
87	Clumsiness (HP:0002312)	1.68970609
88	Decreased muscle mass (HP:0003199)	1.68879665
89	Preaxial hand polydactyly (HP:0001177)	1.68606729
90	Oligodactyly (hands) (HP:0001180)	1.68351297
91	Large for gestational age (HP:0001520)	1.68325984
92	Tubulointerstitial abnormality (HP:0001969)	1.68249082
93	Atonic seizures (HP:0010819)	1.67845185
94	Short foot (HP:0001773)	1.67268789
95	Hypothermia (HP:0002045)	1.66714447
96	Volvulus (HP:0002580)	1.65954622
97	Aplasia/Hypoplasia of the lens (HP:0008063)	1.65046911
98	Multicystic kidney dysplasia (HP:0000003)	1.64523036
99	Polymicrogyria (HP:0002126)	1.63956604
100	Oculomotor apraxia (HP:0000657)	1.62579033

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.55431427
2	CASK	3.16640696
3	BMPR1B	3.05007541
4	WNK3	2.69765748
5	NUAK1	2.66489856
6	TRIM28	2.52383917
7	MAP4K2	2.44694234
8	TNIK	2.41379749
9	PINK1	2.41062157
10	MARK1	2.36656824
11	MAP3K4	2.26419790
12	TIE1	2.21061040
13	ADRBK2	2.12002573
14	MAPK13	2.11747894
15	BCR	1.95606708
16	ACVR1B	1.92497254
17	GRK1	1.86323161
18	ERBB3	1.74432187
19	ZAK	1.72700680
20	INSRR	1.64032324
21	EIF2AK3	1.64005389
22	TAOK3	1.52874774
23	MAP2K7	1.46423820
24	PAK3	1.46315603
25	PLK2	1.45263958
26	CSNK1G2	1.43923136
27	STK38L	1.37529057
28	WNK4	1.22642862
29	CSNK1G1	1.21102783
30	CSNK1G3	1.19783393
31	DYRK2	1.16601541
32	EPHA3	1.15534913
33	NTRK3	1.14419086
34	STK39	1.14053371
35	MKNK2	1.13412799
36	CSNK1A1L	1.12843734
37	OXSR1	1.12130129
38	PRKCE	1.07338083
39	FER	0.98918613
40	OBSCN	0.97824259
41	DYRK3	0.94298217
42	PIK3CA	0.82853494
43	TGFBR1	0.82491198
44	MST4	0.82166089
45	SRPK1	0.82045494
46	PRKCG	0.80371572
47	BCKDK	0.80002047
48	PHKG2	0.78892366
49	PHKG1	0.78892366
50	AKT3	0.77040055
51	STK16	0.75107063
52	PLK4	0.73982447
53	NTRK2	0.73937554
54	EPHA4	0.69090832
55	DAPK2	0.69034911
56	ERBB4	0.67439475
57	PLK3	0.66107024
58	CAMKK2	0.63092619
59	VRK1	0.62383663
60	TEC	0.62108939
61	ADRBK1	0.58355918
62	PKN1	0.55102471
63	CAMK2A	0.54256416
64	FGFR2	0.54225461
65	MKNK1	0.54017115
66	PTK2B	0.52584496
67	BRD4	0.51776399
68	MUSK	0.50824012
69	CSNK1D	0.48594816
70	BRSK2	0.48414500
71	TLK1	0.47612959
72	PRKCQ	0.45867345
73	PLK1	0.45500315
74	LATS1	0.45314762
75	PNCK	0.45253479
76	STK3	0.43415868
77	IRAK1	0.42876157
78	DYRK1A	0.42552217
79	PRKACA	0.42414854
80	PRKG1	0.41853725
81	ATM	0.41027050
82	MAP2K4	0.40158529
83	CDK3	0.39942599
84	PRKACB	0.38533818
85	PRKAA1	0.38480409
86	MINK1	0.38353902
87	NLK	0.36846909
88	RPS6KA5	0.36589666
89	PIK3CG	0.35706082
90	PRKCZ	0.34351625
91	CSNK1A1	0.33459162
92	SGK2	0.30644781
93	ABL1	0.27593705
94	CCNB1	0.27036382
95	CHUK	0.26706668
96	CAMK1	0.26558605
97	FLT3	0.26203454
98	CDK19	0.25048251
99	CDK5	0.24558070
100	PRKCA	0.24468346

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.72744501
2	Nicotine addiction_Homo sapiens_hsa05033	2.69324244
3	Protein export_Homo sapiens_hsa03060	2.68757655
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.59586390
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.59509642
6	Butanoate metabolism_Homo sapiens_hsa00650	2.57419632
7	Basal transcription factors_Homo sapiens_hsa03022	2.44755211
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.24546106
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.10745804
10	Selenocompound metabolism_Homo sapiens_hsa00450	1.95713951
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.93648065
12	Olfactory transduction_Homo sapiens_hsa04740	1.89010498
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.87944446
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.87507688
15	Propanoate metabolism_Homo sapiens_hsa00640	1.86039136
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.85714182
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.83369041
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.83046243
19	RNA degradation_Homo sapiens_hsa03018	1.80412994
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.76938558
21	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.76314116
22	Circadian rhythm_Homo sapiens_hsa04710	1.70845575
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.66631879
24	RNA polymerase_Homo sapiens_hsa03020	1.61607354
25	Regulation of autophagy_Homo sapiens_hsa04140	1.59930496
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.57668009
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.55897908
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.46641717
29	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.42619477
30	Taste transduction_Homo sapiens_hsa04742	1.40791307
31	GABAergic synapse_Homo sapiens_hsa04727	1.40202523
32	Homologous recombination_Homo sapiens_hsa03440	1.37794162
33	Morphine addiction_Homo sapiens_hsa05032	1.37242920
34	Peroxisome_Homo sapiens_hsa04146	1.32939005
35	Oxidative phosphorylation_Homo sapiens_hsa00190	1.32068016
36	Caffeine metabolism_Homo sapiens_hsa00232	1.24504344
37	Circadian entrainment_Homo sapiens_hsa04713	1.21730554
38	Non-homologous end-joining_Homo sapiens_hsa03450	1.21324494
39	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.21084354
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.19585542
41	Insulin secretion_Homo sapiens_hsa04911	1.16766141
42	Steroid biosynthesis_Homo sapiens_hsa00100	1.14828888
43	Fatty acid elongation_Homo sapiens_hsa00062	1.12840259
44	ABC transporters_Homo sapiens_hsa02010	1.09848079
45	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.09006736
46	Glutamatergic synapse_Homo sapiens_hsa04724	1.06183375
47	Parkinsons disease_Homo sapiens_hsa05012	0.99257863
48	Dopaminergic synapse_Homo sapiens_hsa04728	0.98562783
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.98154473
50	Serotonergic synapse_Homo sapiens_hsa04726	0.92890158
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.90083413
52	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.89577565
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.89380448
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.87884013
55	Huntingtons disease_Homo sapiens_hsa05016	0.85928051
56	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.83549981
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.83268245
58	Cardiac muscle contraction_Homo sapiens_hsa04260	0.77614935
59	Cocaine addiction_Homo sapiens_hsa05030	0.77471457
60	Amphetamine addiction_Homo sapiens_hsa05031	0.74419887
61	Long-term depression_Homo sapiens_hsa04730	0.73967433
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73069700
63	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.69935051
64	Calcium signaling pathway_Homo sapiens_hsa04020	0.68390789
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.66900044
66	RNA transport_Homo sapiens_hsa03013	0.65492921
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.65404965
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64619000
69	Salivary secretion_Homo sapiens_hsa04970	0.63986411
70	Oocyte meiosis_Homo sapiens_hsa04114	0.60716591
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60138015
72	Retinol metabolism_Homo sapiens_hsa00830	0.59994290
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.59690827
74	Purine metabolism_Homo sapiens_hsa00230	0.57656281
75	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55543051
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.55081157
77	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.54362937
78	Metabolic pathways_Homo sapiens_hsa01100	0.53645921
79	Sulfur metabolism_Homo sapiens_hsa00920	0.52168146
80	Alzheimers disease_Homo sapiens_hsa05010	0.51144152
81	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.51142395
82	Sphingolipid metabolism_Homo sapiens_hsa00600	0.50514274
83	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.50023501
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48951973
85	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.47899669
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47854536
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46266074
88	Axon guidance_Homo sapiens_hsa04360	0.44943532
89	Fatty acid degradation_Homo sapiens_hsa00071	0.43575509
90	cAMP signaling pathway_Homo sapiens_hsa04024	0.43306614
91	Lysine degradation_Homo sapiens_hsa00310	0.42353661
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.42089715
93	Cholinergic synapse_Homo sapiens_hsa04725	0.41929725
94	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.41368015
95	p53 signaling pathway_Homo sapiens_hsa04115	0.35823206
96	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.35124547
97	Proteasome_Homo sapiens_hsa03050	0.32354943
98	Histidine metabolism_Homo sapiens_hsa00340	0.30906505
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.28975212
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.28072684

ZNF555

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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