ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.60393901
2	fucose catabolic process (GO:0019317)	5.20080877
3	L-fucose metabolic process (GO:0042354)	5.20080877
4	L-fucose catabolic process (GO:0042355)	5.20080877
5	kynurenine metabolic process (GO:0070189)	4.30125095
6	indole-containing compound catabolic process (GO:0042436)	4.24767497
7	indolalkylamine catabolic process (GO:0046218)	4.24767497
8	tryptophan catabolic process (GO:0006569)	4.24767497
9	cellular ketone body metabolic process (GO:0046950)	4.05716397
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.99843997
11	indolalkylamine metabolic process (GO:0006586)	3.93380436
12	detection of light stimulus involved in sensory perception (GO:0050962)	3.92806018
13	detection of light stimulus involved in visual perception (GO:0050908)	3.92806018
14	tryptophan metabolic process (GO:0006568)	3.82947075
15	response to pheromone (GO:0019236)	3.76467545
16	DNA deamination (GO:0045006)	3.65472537
17	ketone body metabolic process (GO:1902224)	3.63268205
18	gamma-aminobutyric acid transport (GO:0015812)	3.58544855
19	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.54345616
20	negative regulation of telomere maintenance (GO:0032205)	3.44134710
21	cornea development in camera-type eye (GO:0061303)	3.38563045
22	indole-containing compound metabolic process (GO:0042430)	3.27138959
23	kidney morphogenesis (GO:0060993)	3.25898678
24	regulation of hippo signaling (GO:0035330)	3.25483078
25	water-soluble vitamin biosynthetic process (GO:0042364)	3.24162799
26	neuronal action potential (GO:0019228)	3.21160154
27	primary amino compound metabolic process (GO:1901160)	3.19783559
28	regulation of action potential (GO:0098900)	3.17124590
29	sulfation (GO:0051923)	3.16136316
30	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.10686800
31	epithelial cilium movement (GO:0003351)	3.09505782
32	nonmotile primary cilium assembly (GO:0035058)	3.07911438
33	NADH dehydrogenase complex assembly (GO:0010257)	3.07010907
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.07010907
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.07010907
36	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.05798769
37	piRNA metabolic process (GO:0034587)	3.05525055
38	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.99588819
39	regulation of translation, ncRNA-mediated (GO:0045974)	2.99588819
40	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.99588819
41	cellular response to ATP (GO:0071318)	2.99454679
42	platelet dense granule organization (GO:0060155)	2.98911763
43	neuronal action potential propagation (GO:0019227)	2.96735521
44	nephron tubule morphogenesis (GO:0072078)	2.95818929
45	nephron epithelium morphogenesis (GO:0072088)	2.95818929
46	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.94460212
47	behavioral response to ethanol (GO:0048149)	2.93753903
48	synaptic transmission, cholinergic (GO:0007271)	2.92154338
49	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.89666722
50	protein-cofactor linkage (GO:0018065)	2.89521376
51	serotonin metabolic process (GO:0042428)	2.88911453
52	regulation of gene silencing by RNA (GO:0060966)	2.88662929
53	regulation of posttranscriptional gene silencing (GO:0060147)	2.88662929
54	regulation of gene silencing by miRNA (GO:0060964)	2.88662929
55	reciprocal DNA recombination (GO:0035825)	2.87078633
56	reciprocal meiotic recombination (GO:0007131)	2.87078633
57	protein import into peroxisome matrix (GO:0016558)	2.84989343
58	ubiquinone biosynthetic process (GO:0006744)	2.81470077
59	respiratory chain complex IV assembly (GO:0008535)	2.81356823
60	fucosylation (GO:0036065)	2.79584667
61	protein complex biogenesis (GO:0070271)	2.78987938
62	mitochondrial respiratory chain complex assembly (GO:0033108)	2.76413566
63	protein localization to cilium (GO:0061512)	2.73857216
64	NAD biosynthetic process (GO:0009435)	2.73088438
65	amine catabolic process (GO:0009310)	2.72628786
66	cellular biogenic amine catabolic process (GO:0042402)	2.72628786
67	positive regulation of fatty acid transport (GO:2000193)	2.72619737
68	preassembly of GPI anchor in ER membrane (GO:0016254)	2.72224028
69	protein polyglutamylation (GO:0018095)	2.69771071
70	reflex (GO:0060004)	2.69585636
71	axoneme assembly (GO:0035082)	2.67123605
72	regulation of mesoderm development (GO:2000380)	2.65216161
73	positive regulation of CREB transcription factor activity (GO:0032793)	2.65077655
74	neural tube formation (GO:0001841)	2.64875443
75	spinal cord motor neuron differentiation (GO:0021522)	2.63628444
76	ubiquinone metabolic process (GO:0006743)	2.61007146
77	negative regulation of mast cell activation (GO:0033004)	2.55596130
78	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.55425343
79	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.54132204
80	histone-serine phosphorylation (GO:0035404)	2.53321714
81	cAMP catabolic process (GO:0006198)	2.51728893
82	rhodopsin mediated signaling pathway (GO:0016056)	2.51724384
83	cilium movement (GO:0003341)	2.50920943
84	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.50765667
85	oxidative demethylation (GO:0070989)	2.50674142
86	DNA methylation involved in gamete generation (GO:0043046)	2.50622806
87	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.49021493
88	cilium or flagellum-dependent cell motility (GO:0001539)	2.48887326
89	cilium morphogenesis (GO:0060271)	2.46882057
90	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.46854779
91	multicellular organism reproduction (GO:0032504)	2.46137354
92	positive regulation of fatty acid oxidation (GO:0046321)	2.46011448
93	endosome to melanosome transport (GO:0035646)	2.45906560
94	endosome to pigment granule transport (GO:0043485)	2.45906560
95	negative regulation of systemic arterial blood pressure (GO:0003085)	2.45577183
96	rRNA catabolic process (GO:0016075)	2.45073461
97	regulation of triglyceride biosynthetic process (GO:0010866)	2.44585179
98	pseudouridine synthesis (GO:0001522)	2.43830879
99	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.42463242
100	cilium organization (GO:0044782)	2.42431164

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	4.31933864
2	VDR_22108803_ChIP-Seq_LS180_Human	3.64457448
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.54482584
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.88491888
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.87339712
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.86726165
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.38467617
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10356503
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.09158094
10	EWS_26573619_Chip-Seq_HEK293_Human	2.06601359
11	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.01634161
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.99437602
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.98822874
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98716347
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.95737078
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.93703824
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.90708898
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.89420574
19	FUS_26573619_Chip-Seq_HEK293_Human	1.87503800
20	P300_19829295_ChIP-Seq_ESCs_Human	1.77233125
21	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.76650358
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.73023120
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.68802570
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67174484
25	REST_21632747_ChIP-Seq_MESCs_Mouse	1.58825661
26	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.56925900
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56689658
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.54921216
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54603947
30	* MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.51932392
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.51509826
32	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51104381
33	STAT3_23295773_ChIP-Seq_U87_Human	1.50669773
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.49966387
35	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.47439906
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46572806
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46548978
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45298405
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43931417
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43852392
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43852392
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.43596327
43	AR_25329375_ChIP-Seq_VCAP_Human	1.42682654
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.41288286
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.39819181
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39819181
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.39125935
48	TCF4_23295773_ChIP-Seq_U87_Human	1.36833049
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33511686
50	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28358132
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27962851
52	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26636625
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25959931
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25959931
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.25648570
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25648570
57	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.25643444
58	HOXB7_26014856_ChIP-Seq_BT474_Human	1.25521491
59	AR_21572438_ChIP-Seq_LNCaP_Human	1.25296732
60	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25055733
61	AR_20517297_ChIP-Seq_VCAP_Human	1.21845338
62	NCOR_22424771_ChIP-Seq_293T_Human	1.21633494
63	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21431705
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20807283
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18487972
66	ERA_21632823_ChIP-Seq_H3396_Human	1.17912991
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17451422
68	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16572432
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.15901347
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15615456
71	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.14191842
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14102561
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.13950948
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12454740
75	TP53_16413492_ChIP-PET_HCT116_Human	1.09772259
76	DROSHA_22980978_ChIP-Seq_HELA_Human	1.09155833
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07412292
78	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07366718
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06989688
80	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.04433322
81	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02327413
82	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.02259939
83	TAF2_19829295_ChIP-Seq_ESCs_Human	1.02126105
84	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00253984
85	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00172587
86	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.00163815
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00140905
88	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.99822717
89	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99609134
90	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.99482504
91	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98706867
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98683106
93	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.98365722
94	* MYC_19829295_ChIP-Seq_ESCs_Human	0.96046661
95	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.95436908
96	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94152740
97	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.93733031
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93157297
99	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.92278315
100	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.91627383

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.29497304
2	MP0002102_abnormal_ear_morphology	2.99225286
3	MP0003646_muscle_fatigue	2.79598177
4	MP0003136_yellow_coat_color	2.67888482
5	MP0008877_abnormal_DNA_methylation	2.56783831
6	MP0005551_abnormal_eye_electrophysiolog	2.50077447
7	MP0001968_abnormal_touch/_nociception	2.43814130
8	MP0000569_abnormal_digit_pigmentation	2.31166124
9	MP0008875_abnormal_xenobiotic_pharmacok	2.31000790
10	MP0004043_abnormal_pH_regulation	2.26618044
11	MP0009046_muscle_twitch	2.17299929
12	MP0001986_abnormal_taste_sensitivity	2.10549670
13	MP0009745_abnormal_behavioral_response	2.05675961
14	MP0008872_abnormal_physiological_respon	2.04405175
15	MP0002837_dystrophic_cardiac_calcinosis	1.92885141
16	MP0004147_increased_porphyrin_level	1.91401314
17	MP0004142_abnormal_muscle_tone	1.87882916
18	MP0001485_abnormal_pinna_reflex	1.87581070
19	MP0002876_abnormal_thyroid_physiology	1.84868089
20	MP0005645_abnormal_hypothalamus_physiol	1.83874116
21	MP0002736_abnormal_nociception_after	1.83560469
22	MP0004133_heterotaxia	1.82370891
23	MP0002938_white_spotting	1.79620478
24	MP0002638_abnormal_pupillary_reflex	1.79237626
25	MP0002653_abnormal_ependyma_morphology	1.78366983
26	MP0000427_abnormal_hair_cycle	1.75550911
27	MP0004145_abnormal_muscle_electrophysio	1.71073836
28	MP0006292_abnormal_olfactory_placode	1.69593553
29	MP0002272_abnormal_nervous_system	1.66603963
30	MP0004885_abnormal_endolymph	1.65115749
31	MP0005377_hearing/vestibular/ear_phenot	1.58879185
32	MP0003878_abnormal_ear_physiology	1.58879185
33	MP0005253_abnormal_eye_physiology	1.52214235
34	MP0002735_abnormal_chemical_nociception	1.52130736
35	MP0006072_abnormal_retinal_apoptosis	1.46530705
36	MP0000631_abnormal_neuroendocrine_gland	1.45451897
37	MP0001501_abnormal_sleep_pattern	1.45228509
38	MP0003011_delayed_dark_adaptation	1.45045182
39	MP0005174_abnormal_tail_pigmentation	1.40515109
40	MP0002160_abnormal_reproductive_system	1.38012930
41	MP0002064_seizures	1.36459250
42	MP0001486_abnormal_startle_reflex	1.36126842
43	MP0005084_abnormal_gallbladder_morpholo	1.33742011
44	MP0005646_abnormal_pituitary_gland	1.33229067
45	MP0002572_abnormal_emotion/affect_behav	1.30840080
46	MP0003880_abnormal_central_pattern	1.30665264
47	MP0005389_reproductive_system_phenotype	1.29724160
48	MP0006276_abnormal_autonomic_nervous	1.28977014
49	MP0004742_abnormal_vestibular_system	1.28110303
50	MP0003787_abnormal_imprinting	1.27346820
51	MP0005167_abnormal_blood-brain_barrier	1.26723655
52	MP0002234_abnormal_pharynx_morphology	1.24917283
53	MP0001970_abnormal_pain_threshold	1.24670660
54	MP0002067_abnormal_sensory_capabilities	1.24458700
55	MP0002557_abnormal_social/conspecific_i	1.18059712
56	MP0001919_abnormal_reproductive_system	1.17480559
57	MP0000372_irregular_coat_pigmentation	1.15021059
58	MP0005386_behavior/neurological_phenoty	1.11933642
59	MP0004924_abnormal_behavior	1.11933642
60	MP0002733_abnormal_thermal_nociception	1.11927191
61	MP0003890_abnormal_embryonic-extraembry	1.11376380
62	MP0000383_abnormal_hair_follicle	1.09724882
63	MP0004215_abnormal_myocardial_fiber	1.07588980
64	MP0000230_abnormal_systemic_arterial	1.07083313
65	MP0003137_abnormal_impulse_conducting	1.06916348
66	MP0002928_abnormal_bile_duct	1.06139135
67	MP0005085_abnormal_gallbladder_physiolo	1.05865414
68	MP0010386_abnormal_urinary_bladder	1.05464328
69	MP0008775_abnormal_heart_ventricle	1.04877560
70	MP0005195_abnormal_posterior_eye	1.04207102
71	MP0004130_abnormal_muscle_cell	1.04004779
72	MP0002277_abnormal_respiratory_mucosa	1.03030348
73	MP0003718_maternal_effect	1.03017667
74	MP0003283_abnormal_digestive_organ	1.02498626
75	MP0003950_abnormal_plasma_membrane	1.01659087
76	MP0003119_abnormal_digestive_system	1.00063487
77	MP0002063_abnormal_learning/memory/cond	0.98668634
78	MP0002734_abnormal_mechanical_nocicepti	0.97957651
79	MP0003635_abnormal_synaptic_transmissio	0.96387936
80	MP0005410_abnormal_fertilization	0.95954908
81	MP0005423_abnormal_somatic_nervous	0.95340033
82	MP0001324_abnormal_eye_pigmentation	0.93999756
83	MP0000026_abnormal_inner_ear	0.92841596
84	MP0010329_abnormal_lipoprotein_level	0.92182532
85	MP0003252_abnormal_bile_duct	0.91437139
86	MP0002752_abnormal_somatic_nervous	0.90527488
87	MP0000538_abnormal_urinary_bladder	0.90206313
88	MP0005171_absent_coat_pigmentation	0.87686972
89	MP0001529_abnormal_vocalization	0.86984643
90	MP0001502_abnormal_circadian_rhythm	0.84408436
91	MP0005332_abnormal_amino_acid	0.82654614
92	MP0001905_abnormal_dopamine_level	0.81562587
93	MP0001984_abnormal_olfaction	0.79439879
94	MP0003698_abnormal_male_reproductive	0.79154943
95	MP0002095_abnormal_skin_pigmentation	0.78587967
96	MP0000647_abnormal_sebaceous_gland	0.77748319
97	MP0008961_abnormal_basal_metabolism	0.77204335
98	MP0005365_abnormal_bile_salt	0.75818565
99	MP0002184_abnormal_innervation	0.75806879
100	MP0005448_abnormal_energy_balance	0.75579176

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.61539459
2	Abnormality of midbrain morphology (HP:0002418)	4.36683246
3	Molar tooth sign on MRI (HP:0002419)	4.36683246
4	Congenital stationary night blindness (HP:0007642)	4.05496319
5	Pancreatic fibrosis (HP:0100732)	3.98223774
6	Abnormality of alanine metabolism (HP:0010916)	3.79663887
7	Hyperalaninemia (HP:0003348)	3.79663887
8	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.79663887
9	Nephronophthisis (HP:0000090)	3.74632050
10	True hermaphroditism (HP:0010459)	3.70962114
11	Abnormality of the renal cortex (HP:0011035)	3.62633202
12	Type II lissencephaly (HP:0007260)	3.55491010
13	Birth length less than 3rd percentile (HP:0003561)	3.51088561
14	Attenuation of retinal blood vessels (HP:0007843)	3.36212844
15	Tubular atrophy (HP:0000092)	3.34069112
16	Hyperventilation (HP:0002883)	3.32515496
17	Abnormality of the renal medulla (HP:0100957)	3.30812545
18	Inability to walk (HP:0002540)	3.11088974
19	Abnormal drinking behavior (HP:0030082)	3.02401591
20	Polydipsia (HP:0001959)	3.02401591
21	Pendular nystagmus (HP:0012043)	2.86812844
22	Cystic liver disease (HP:0006706)	2.83500219
23	Large for gestational age (HP:0001520)	2.78570885
24	Abolished electroretinogram (ERG) (HP:0000550)	2.74553102
25	Medial flaring of the eyebrow (HP:0010747)	2.72262790
26	Decreased circulating renin level (HP:0003351)	2.71537300
27	Progressive inability to walk (HP:0002505)	2.70673225
28	Patellar aplasia (HP:0006443)	2.67344172
29	Chronic hepatic failure (HP:0100626)	2.62779482
30	Gaze-evoked nystagmus (HP:0000640)	2.61256155
31	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.60912459
32	Absent/shortened dynein arms (HP:0200106)	2.60912459
33	Severe muscular hypotonia (HP:0006829)	2.60907058
34	Cerebellar dysplasia (HP:0007033)	2.60382547
35	Congenital, generalized hypertrichosis (HP:0004540)	2.56394861
36	Protruding tongue (HP:0010808)	2.55879021
37	Genetic anticipation (HP:0003743)	2.54687737
38	Aplasia/Hypoplasia of the patella (HP:0006498)	2.53742816
39	Abnormality of the pons (HP:0007361)	2.53641463
40	Chorioretinal atrophy (HP:0000533)	2.49773091
41	Concave nail (HP:0001598)	2.48800523
42	Increased corneal curvature (HP:0100692)	2.48085063
43	Keratoconus (HP:0000563)	2.48085063
44	Hypoplasia of the pons (HP:0012110)	2.46210751
45	Lissencephaly (HP:0001339)	2.45496832
46	Decreased central vision (HP:0007663)	2.38490376
47	Renal cortical cysts (HP:0000803)	2.33827620
48	Progressive cerebellar ataxia (HP:0002073)	2.33562852
49	Polyuria (HP:0000103)	2.32555568
50	Sclerocornea (HP:0000647)	2.32021770
51	Furrowed tongue (HP:0000221)	2.28441212
52	Clumsiness (HP:0002312)	2.20366504
53	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.18505364
54	Bile duct proliferation (HP:0001408)	2.16189423
55	Abnormal biliary tract physiology (HP:0012439)	2.16189423
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.15532299
57	Abnormal rod and cone electroretinograms (HP:0008323)	2.14633571
58	Congenital hepatic fibrosis (HP:0002612)	2.12171847
59	Febrile seizures (HP:0002373)	2.07590308
60	Gait imbalance (HP:0002141)	2.05604862
61	Broad-based gait (HP:0002136)	2.04384703
62	Abnormal respiratory motile cilium morphology (HP:0005938)	2.02307510
63	Abnormal respiratory epithelium morphology (HP:0012253)	2.02307510
64	Fair hair (HP:0002286)	2.01711927
65	Anencephaly (HP:0002323)	2.01433421
66	Bony spicule pigmentary retinopathy (HP:0007737)	2.00209591
67	Male pseudohermaphroditism (HP:0000037)	1.96847712
68	Hemiparesis (HP:0001269)	1.96743404
69	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.94046046
70	Congenital primary aphakia (HP:0007707)	1.93553960
71	Partial agenesis of the corpus callosum (HP:0001338)	1.90159575
72	Hyperglycinuria (HP:0003108)	1.88793266
73	Breast hypoplasia (HP:0003187)	1.88204412
74	Abnormal urine output (HP:0012590)	1.84834864
75	Tachypnea (HP:0002789)	1.82359125
76	Optic disc pallor (HP:0000543)	1.82169969
77	Stomach cancer (HP:0012126)	1.82140959
78	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.81769502
79	Pachygyria (HP:0001302)	1.78013431
80	Nephrogenic diabetes insipidus (HP:0009806)	1.75211892
81	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.74372567
82	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.73896849
83	Abnormal number of erythroid precursors (HP:0012131)	1.72825586
84	Rib fusion (HP:0000902)	1.72451042
85	Dyskinesia (HP:0100660)	1.71980204
86	Congenital sensorineural hearing impairment (HP:0008527)	1.71645793
87	Increased CSF lactate (HP:0002490)	1.71093602
88	Abnormality of renin-angiotensin system (HP:0000847)	1.68365192
89	Ketosis (HP:0001946)	1.67128795
90	Bilateral microphthalmos (HP:0007633)	1.66801382
91	Dandy-Walker malformation (HP:0001305)	1.66549462
92	Small hand (HP:0200055)	1.65924573
93	Mesangial abnormality (HP:0001966)	1.65872667
94	Ketoacidosis (HP:0001993)	1.65351916
95	Optic nerve hypoplasia (HP:0000609)	1.64998786
96	Widely spaced teeth (HP:0000687)	1.64848373
97	Type 2 muscle fiber atrophy (HP:0003554)	1.64725070
98	Bulbous nose (HP:0000414)	1.64113514
99	Abnormal ciliary motility (HP:0012262)	1.63624154
100	Genital tract atresia (HP:0001827)	1.62036040

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.29546609
2	BMPR1B	3.91845234
3	ADRBK2	3.85152896
4	ACVR1B	3.68631919
5	WNK4	3.44195742
6	ZAK	3.23784152
7	TLK1	2.89081292
8	GRK1	2.48905676
9	INSRR	2.25427174
10	PINK1	2.11363399
11	WNK3	2.10605843
12	DAPK2	1.98537330
13	MAP4K2	1.97776861
14	TGFBR1	1.84913672
15	OXSR1	1.78763384
16	NUAK1	1.77985781
17	TAOK3	1.77971103
18	MAPK13	1.71269207
19	STK39	1.66706241
20	PNCK	1.64095229
21	ADRBK1	1.63560309
22	MAP3K4	1.54324064
23	CASK	1.42375887
24	MKNK2	1.41341425
25	CAMKK2	1.39642077
26	MUSK	1.37261326
27	MAPK15	1.23245700
28	TNIK	1.14160940
29	MAPKAPK3	1.13367005
30	PRKCG	1.06973131
31	PIK3CA	1.06496993
32	NEK2	0.93530133
33	PTK2B	0.92964387
34	MARK1	0.91990967
35	MAP2K6	0.91491514
36	MAPKAPK5	0.90429592
37	MAP2K7	0.89099933
38	TXK	0.88103121
39	PHKG1	0.85800535
40	PHKG2	0.85800535
41	DYRK2	0.84638295
42	PRKCE	0.81746036
43	TIE1	0.79356743
44	WEE1	0.77753862
45	BRSK2	0.76849079
46	SIK2	0.75274570
47	PAK3	0.73345822
48	NTRK3	0.71254788
49	OBSCN	0.69863170
50	RPS6KA5	0.69402709
51	CAMK1D	0.68622393
52	PRKCQ	0.64389731
53	VRK1	0.63657170
54	NTRK2	0.62595628
55	PKN1	0.61974057
56	WNK1	0.61541001
57	MKNK1	0.57909693
58	STK38L	0.57216559
59	MAP2K1	0.55750424
60	TRPM7	0.53708119
61	PLK4	0.52005526
62	RPS6KA6	0.51943431
63	CAMK2A	0.51813253
64	IKBKB	0.51786512
65	PRKCI	0.51493542
66	BCKDK	0.49176474
67	STK11	0.48849633
68	CAMK1	0.47414566
69	CAMKK1	0.45875262
70	PLK2	0.45682721
71	FGFR2	0.44350047
72	MAP2K4	0.43672297
73	STK3	0.42541344
74	CHUK	0.42166298
75	CSNK1G2	0.41071814
76	PRKACA	0.40980269
77	AKT3	0.39996994
78	CSNK1G1	0.39749188
79	TEC	0.39720892
80	CSNK1D	0.39517666
81	TYRO3	0.39285148
82	NLK	0.38823436
83	CAMK1G	0.37967822
84	IRAK1	0.37658102
85	PRKAA1	0.36677105
86	PRKAA2	0.36109397
87	MAP2K2	0.34852832
88	CHEK2	0.34306415
89	FLT3	0.33707441
90	PRKCA	0.33264932
91	LIMK1	0.33010725
92	CSNK1A1	0.32919575
93	NME1	0.32818439
94	PLK3	0.31225973
95	KIT	0.29178648
96	TRIM28	0.29176461
97	PLK1	0.28975362
98	PRKCH	0.27534409
99	CSNK1A1L	0.26446387
100	PRKG1	0.25773764

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	3.15202656
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.11571208
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.07126440
4	Phototransduction_Homo sapiens_hsa04744	2.63422619
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.55058375
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.37929014
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.35637296
8	Butanoate metabolism_Homo sapiens_hsa00650	2.35539162
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.32199030
10	Tryptophan metabolism_Homo sapiens_hsa00380	2.10818826
11	Nicotine addiction_Homo sapiens_hsa05033	2.06032747
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.05820997
13	Ether lipid metabolism_Homo sapiens_hsa00565	2.03802600
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.01520361
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.95142560
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.94479926
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.83032848
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.79770350
19	Sulfur relay system_Homo sapiens_hsa04122	1.74388341
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.72168137
21	Homologous recombination_Homo sapiens_hsa03440	1.70034373
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.54861148
23	Caffeine metabolism_Homo sapiens_hsa00232	1.52333410
24	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.48385544
25	ABC transporters_Homo sapiens_hsa02010	1.40210403
26	Taste transduction_Homo sapiens_hsa04742	1.39991165
27	Morphine addiction_Homo sapiens_hsa05032	1.35914143
28	Basal transcription factors_Homo sapiens_hsa03022	1.33511937
29	RNA polymerase_Homo sapiens_hsa03020	1.32689696
30	One carbon pool by folate_Homo sapiens_hsa00670	1.32275078
31	Parkinsons disease_Homo sapiens_hsa05012	1.30300293
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.29794121
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.26616454
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.25858991
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.25185532
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.23289035
37	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.19885020
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18586347
39	Olfactory transduction_Homo sapiens_hsa04740	1.18217897
40	Peroxisome_Homo sapiens_hsa04146	1.11943303
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08036123
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.05012044
43	Histidine metabolism_Homo sapiens_hsa00340	1.03000398
44	RNA degradation_Homo sapiens_hsa03018	0.99412533
45	Serotonergic synapse_Homo sapiens_hsa04726	0.98464549
46	Circadian entrainment_Homo sapiens_hsa04713	0.98355196
47	Glutamatergic synapse_Homo sapiens_hsa04724	0.97841549
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.96737701
49	Insulin secretion_Homo sapiens_hsa04911	0.95473158
50	Glycerolipid metabolism_Homo sapiens_hsa00561	0.92654740
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.91028056
52	GABAergic synapse_Homo sapiens_hsa04727	0.89910935
53	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.89777457
54	Protein export_Homo sapiens_hsa03060	0.88605177
55	Propanoate metabolism_Homo sapiens_hsa00640	0.87863661
56	Alzheimers disease_Homo sapiens_hsa05010	0.87167602
57	Huntingtons disease_Homo sapiens_hsa05016	0.87008931
58	Retinol metabolism_Homo sapiens_hsa00830	0.86276063
59	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.85459432
60	Calcium signaling pathway_Homo sapiens_hsa04020	0.85079701
61	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.84181116
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80291318
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80065899
64	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.78709481
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69068458
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67029780
67	Salivary secretion_Homo sapiens_hsa04970	0.64506458
68	Mineral absorption_Homo sapiens_hsa04978	0.62311455
69	Ribosome_Homo sapiens_hsa03010	0.62150720
70	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.61041668
71	Regulation of autophagy_Homo sapiens_hsa04140	0.60847276
72	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.60779900
73	Purine metabolism_Homo sapiens_hsa00230	0.55409964
74	Metabolic pathways_Homo sapiens_hsa01100	0.55089181
75	Sulfur metabolism_Homo sapiens_hsa00920	0.54778059
76	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.54093664
77	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53819287
78	Asthma_Homo sapiens_hsa05310	0.50182444
79	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.49861815
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46818553
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46592157
82	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46003051
83	Long-term depression_Homo sapiens_hsa04730	0.45616848
84	Dopaminergic synapse_Homo sapiens_hsa04728	0.40079922
85	Fatty acid degradation_Homo sapiens_hsa00071	0.39951943
86	Basal cell carcinoma_Homo sapiens_hsa05217	0.39726625
87	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.39156653
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39069150
89	Pyrimidine metabolism_Homo sapiens_hsa00240	0.38507700
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.37370585
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.37116002
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36046839
93	Gastric acid secretion_Homo sapiens_hsa04971	0.34079656
94	Bile secretion_Homo sapiens_hsa04976	0.32984496
95	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.32097821
96	Steroid biosynthesis_Homo sapiens_hsa00100	0.31343333
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.30263489
98	Circadian rhythm_Homo sapiens_hsa04710	0.30197639
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.29883139
100	Primary immunodeficiency_Homo sapiens_hsa05340	0.29462470

ZNF556

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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