ZNF556

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.60393901
2fucose catabolic process (GO:0019317)5.20080877
3L-fucose metabolic process (GO:0042354)5.20080877
4L-fucose catabolic process (GO:0042355)5.20080877
5kynurenine metabolic process (GO:0070189)4.30125095
6indole-containing compound catabolic process (GO:0042436)4.24767497
7indolalkylamine catabolic process (GO:0046218)4.24767497
8tryptophan catabolic process (GO:0006569)4.24767497
9cellular ketone body metabolic process (GO:0046950)4.05716397
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.99843997
11indolalkylamine metabolic process (GO:0006586)3.93380436
12detection of light stimulus involved in sensory perception (GO:0050962)3.92806018
13detection of light stimulus involved in visual perception (GO:0050908)3.92806018
14tryptophan metabolic process (GO:0006568)3.82947075
15response to pheromone (GO:0019236)3.76467545
16DNA deamination (GO:0045006)3.65472537
17ketone body metabolic process (GO:1902224)3.63268205
18gamma-aminobutyric acid transport (GO:0015812)3.58544855
19detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.54345616
20negative regulation of telomere maintenance (GO:0032205)3.44134710
21cornea development in camera-type eye (GO:0061303)3.38563045
22indole-containing compound metabolic process (GO:0042430)3.27138959
23kidney morphogenesis (GO:0060993)3.25898678
24regulation of hippo signaling (GO:0035330)3.25483078
25water-soluble vitamin biosynthetic process (GO:0042364)3.24162799
26neuronal action potential (GO:0019228)3.21160154
27primary amino compound metabolic process (GO:1901160)3.19783559
28regulation of action potential (GO:0098900)3.17124590
29sulfation (GO:0051923)3.16136316
30phosphatidylinositol acyl-chain remodeling (GO:0036149)3.10686800
31epithelial cilium movement (GO:0003351)3.09505782
32nonmotile primary cilium assembly (GO:0035058)3.07911438
33NADH dehydrogenase complex assembly (GO:0010257)3.07010907
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07010907
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.07010907
36regulation of nuclear cell cycle DNA replication (GO:0033262)3.05798769
37piRNA metabolic process (GO:0034587)3.05525055
38negative regulation of translation, ncRNA-mediated (GO:0040033)2.99588819
39regulation of translation, ncRNA-mediated (GO:0045974)2.99588819
40negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.99588819
41cellular response to ATP (GO:0071318)2.99454679
42platelet dense granule organization (GO:0060155)2.98911763
43neuronal action potential propagation (GO:0019227)2.96735521
44nephron tubule morphogenesis (GO:0072078)2.95818929
45nephron epithelium morphogenesis (GO:0072088)2.95818929
46negative regulation of reactive oxygen species metabolic process (GO:2000378)2.94460212
47behavioral response to ethanol (GO:0048149)2.93753903
48synaptic transmission, cholinergic (GO:0007271)2.92154338
49negative regulation of synaptic transmission, GABAergic (GO:0032229)2.89666722
50protein-cofactor linkage (GO:0018065)2.89521376
51serotonin metabolic process (GO:0042428)2.88911453
52regulation of gene silencing by RNA (GO:0060966)2.88662929
53regulation of posttranscriptional gene silencing (GO:0060147)2.88662929
54regulation of gene silencing by miRNA (GO:0060964)2.88662929
55reciprocal DNA recombination (GO:0035825)2.87078633
56reciprocal meiotic recombination (GO:0007131)2.87078633
57protein import into peroxisome matrix (GO:0016558)2.84989343
58ubiquinone biosynthetic process (GO:0006744)2.81470077
59respiratory chain complex IV assembly (GO:0008535)2.81356823
60fucosylation (GO:0036065)2.79584667
61protein complex biogenesis (GO:0070271)2.78987938
62mitochondrial respiratory chain complex assembly (GO:0033108)2.76413566
63protein localization to cilium (GO:0061512)2.73857216
64NAD biosynthetic process (GO:0009435)2.73088438
65amine catabolic process (GO:0009310)2.72628786
66cellular biogenic amine catabolic process (GO:0042402)2.72628786
67positive regulation of fatty acid transport (GO:2000193)2.72619737
68preassembly of GPI anchor in ER membrane (GO:0016254)2.72224028
69protein polyglutamylation (GO:0018095)2.69771071
70reflex (GO:0060004)2.69585636
71axoneme assembly (GO:0035082)2.67123605
72regulation of mesoderm development (GO:2000380)2.65216161
73positive regulation of CREB transcription factor activity (GO:0032793)2.65077655
74neural tube formation (GO:0001841)2.64875443
75spinal cord motor neuron differentiation (GO:0021522)2.63628444
76ubiquinone metabolic process (GO:0006743)2.61007146
77negative regulation of mast cell activation (GO:0033004)2.55596130
78regulation of rhodopsin mediated signaling pathway (GO:0022400)2.55425343
79phosphatidylserine acyl-chain remodeling (GO:0036150)2.54132204
80histone-serine phosphorylation (GO:0035404)2.53321714
81cAMP catabolic process (GO:0006198)2.51728893
82rhodopsin mediated signaling pathway (GO:0016056)2.51724384
83cilium movement (GO:0003341)2.50920943
84G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50765667
85oxidative demethylation (GO:0070989)2.50674142
86DNA methylation involved in gamete generation (GO:0043046)2.50622806
87RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.49021493
88cilium or flagellum-dependent cell motility (GO:0001539)2.48887326
89cilium morphogenesis (GO:0060271)2.46882057
90membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.46854779
91multicellular organism reproduction (GO:0032504)2.46137354
92positive regulation of fatty acid oxidation (GO:0046321)2.46011448
93endosome to melanosome transport (GO:0035646)2.45906560
94endosome to pigment granule transport (GO:0043485)2.45906560
95negative regulation of systemic arterial blood pressure (GO:0003085)2.45577183
96rRNA catabolic process (GO:0016075)2.45073461
97regulation of triglyceride biosynthetic process (GO:0010866)2.44585179
98pseudouridine synthesis (GO:0001522)2.43830879
99phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.42463242
100cilium organization (GO:0044782)2.42431164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela4.31933864
2VDR_22108803_ChIP-Seq_LS180_Human3.64457448
3EZH2_22144423_ChIP-Seq_EOC_Human3.54482584
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88491888
5GBX2_23144817_ChIP-Seq_PC3_Human2.87339712
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.86726165
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38467617
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10356503
9IGF1R_20145208_ChIP-Seq_DFB_Human2.09158094
10EWS_26573619_Chip-Seq_HEK293_Human2.06601359
11EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.01634161
12FLI1_27457419_Chip-Seq_LIVER_Mouse1.99437602
13POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98822874
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98716347
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95737078
16ER_23166858_ChIP-Seq_MCF-7_Human1.93703824
17TAF15_26573619_Chip-Seq_HEK293_Human1.90708898
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.89420574
19FUS_26573619_Chip-Seq_HEK293_Human1.87503800
20P300_19829295_ChIP-Seq_ESCs_Human1.77233125
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76650358
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.73023120
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68802570
24IRF1_19129219_ChIP-ChIP_H3396_Human1.67174484
25REST_21632747_ChIP-Seq_MESCs_Mouse1.58825661
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56925900
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56689658
28TP53_22573176_ChIP-Seq_HFKS_Human1.54921216
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54603947
30* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51932392
31BCAT_22108803_ChIP-Seq_LS180_Human1.51509826
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51104381
33STAT3_23295773_ChIP-Seq_U87_Human1.50669773
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.49966387
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47439906
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46572806
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46548978
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.45298405
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43931417
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43852392
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.43852392
42MYC_18940864_ChIP-ChIP_HL60_Human1.43596327
43AR_25329375_ChIP-Seq_VCAP_Human1.42682654
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41288286
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39819181
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39819181
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.39125935
48TCF4_23295773_ChIP-Seq_U87_Human1.36833049
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33511686
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28358132
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27962851
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26636625
53NANOG_19829295_ChIP-Seq_ESCs_Human1.25959931
54SOX2_19829295_ChIP-Seq_ESCs_Human1.25959931
55CBP_20019798_ChIP-Seq_JUKART_Human1.25648570
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25648570
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25643444
58HOXB7_26014856_ChIP-Seq_BT474_Human1.25521491
59AR_21572438_ChIP-Seq_LNCaP_Human1.25296732
60SMAD4_21799915_ChIP-Seq_A2780_Human1.25055733
61AR_20517297_ChIP-Seq_VCAP_Human1.21845338
62NCOR_22424771_ChIP-Seq_293T_Human1.21633494
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21431705
64RUNX2_22187159_ChIP-Seq_PCA_Human1.20807283
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.18487972
66ERA_21632823_ChIP-Seq_H3396_Human1.17912991
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17451422
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16572432
69TCF4_22108803_ChIP-Seq_LS180_Human1.15901347
70RNF2_27304074_Chip-Seq_NSC_Mouse1.15615456
71GABP_17652178_ChIP-ChIP_JURKAT_Human1.14191842
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14102561
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13950948
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.12454740
75TP53_16413492_ChIP-PET_HCT116_Human1.09772259
76DROSHA_22980978_ChIP-Seq_HELA_Human1.09155833
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07412292
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.07366718
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06989688
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04433322
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.02327413
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.02259939
83TAF2_19829295_ChIP-Seq_ESCs_Human1.02126105
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00253984
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.00172587
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.00163815
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.00140905
88EED_16625203_ChIP-ChIP_MESCs_Mouse0.99822717
89P53_21459846_ChIP-Seq_SAOS-2_Human0.99609134
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99482504
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98706867
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98683106
93JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98365722
94* MYC_19829295_ChIP-Seq_ESCs_Human0.96046661
95REST_18959480_ChIP-ChIP_MESCs_Mouse0.95436908
96NANOG_20526341_ChIP-Seq_ESCs_Human0.94152740
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93733031
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.93157297
99EST1_17652178_ChIP-ChIP_JURKAT_Human0.92278315
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91627383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.29497304
2MP0002102_abnormal_ear_morphology2.99225286
3MP0003646_muscle_fatigue2.79598177
4MP0003136_yellow_coat_color2.67888482
5MP0008877_abnormal_DNA_methylation2.56783831
6MP0005551_abnormal_eye_electrophysiolog2.50077447
7MP0001968_abnormal_touch/_nociception2.43814130
8MP0000569_abnormal_digit_pigmentation2.31166124
9MP0008875_abnormal_xenobiotic_pharmacok2.31000790
10MP0004043_abnormal_pH_regulation2.26618044
11MP0009046_muscle_twitch2.17299929
12MP0001986_abnormal_taste_sensitivity2.10549670
13MP0009745_abnormal_behavioral_response2.05675961
14MP0008872_abnormal_physiological_respon2.04405175
15MP0002837_dystrophic_cardiac_calcinosis1.92885141
16MP0004147_increased_porphyrin_level1.91401314
17MP0004142_abnormal_muscle_tone1.87882916
18MP0001485_abnormal_pinna_reflex1.87581070
19MP0002876_abnormal_thyroid_physiology1.84868089
20MP0005645_abnormal_hypothalamus_physiol1.83874116
21MP0002736_abnormal_nociception_after1.83560469
22MP0004133_heterotaxia1.82370891
23MP0002938_white_spotting1.79620478
24MP0002638_abnormal_pupillary_reflex1.79237626
25MP0002653_abnormal_ependyma_morphology1.78366983
26MP0000427_abnormal_hair_cycle1.75550911
27MP0004145_abnormal_muscle_electrophysio1.71073836
28MP0006292_abnormal_olfactory_placode1.69593553
29MP0002272_abnormal_nervous_system1.66603963
30MP0004885_abnormal_endolymph1.65115749
31MP0005377_hearing/vestibular/ear_phenot1.58879185
32MP0003878_abnormal_ear_physiology1.58879185
33MP0005253_abnormal_eye_physiology1.52214235
34MP0002735_abnormal_chemical_nociception1.52130736
35MP0006072_abnormal_retinal_apoptosis1.46530705
36MP0000631_abnormal_neuroendocrine_gland1.45451897
37MP0001501_abnormal_sleep_pattern1.45228509
38MP0003011_delayed_dark_adaptation1.45045182
39MP0005174_abnormal_tail_pigmentation1.40515109
40MP0002160_abnormal_reproductive_system1.38012930
41MP0002064_seizures1.36459250
42MP0001486_abnormal_startle_reflex1.36126842
43MP0005084_abnormal_gallbladder_morpholo1.33742011
44MP0005646_abnormal_pituitary_gland1.33229067
45MP0002572_abnormal_emotion/affect_behav1.30840080
46MP0003880_abnormal_central_pattern1.30665264
47MP0005389_reproductive_system_phenotype1.29724160
48MP0006276_abnormal_autonomic_nervous1.28977014
49MP0004742_abnormal_vestibular_system1.28110303
50MP0003787_abnormal_imprinting1.27346820
51MP0005167_abnormal_blood-brain_barrier1.26723655
52MP0002234_abnormal_pharynx_morphology1.24917283
53MP0001970_abnormal_pain_threshold1.24670660
54MP0002067_abnormal_sensory_capabilities1.24458700
55MP0002557_abnormal_social/conspecific_i1.18059712
56MP0001919_abnormal_reproductive_system1.17480559
57MP0000372_irregular_coat_pigmentation1.15021059
58MP0005386_behavior/neurological_phenoty1.11933642
59MP0004924_abnormal_behavior1.11933642
60MP0002733_abnormal_thermal_nociception1.11927191
61MP0003890_abnormal_embryonic-extraembry1.11376380
62MP0000383_abnormal_hair_follicle1.09724882
63MP0004215_abnormal_myocardial_fiber1.07588980
64MP0000230_abnormal_systemic_arterial1.07083313
65MP0003137_abnormal_impulse_conducting1.06916348
66MP0002928_abnormal_bile_duct1.06139135
67MP0005085_abnormal_gallbladder_physiolo1.05865414
68MP0010386_abnormal_urinary_bladder1.05464328
69MP0008775_abnormal_heart_ventricle1.04877560
70MP0005195_abnormal_posterior_eye1.04207102
71MP0004130_abnormal_muscle_cell1.04004779
72MP0002277_abnormal_respiratory_mucosa1.03030348
73MP0003718_maternal_effect1.03017667
74MP0003283_abnormal_digestive_organ1.02498626
75MP0003950_abnormal_plasma_membrane1.01659087
76MP0003119_abnormal_digestive_system1.00063487
77MP0002063_abnormal_learning/memory/cond0.98668634
78MP0002734_abnormal_mechanical_nocicepti0.97957651
79MP0003635_abnormal_synaptic_transmissio0.96387936
80MP0005410_abnormal_fertilization0.95954908
81MP0005423_abnormal_somatic_nervous0.95340033
82MP0001324_abnormal_eye_pigmentation0.93999756
83MP0000026_abnormal_inner_ear0.92841596
84MP0010329_abnormal_lipoprotein_level0.92182532
85MP0003252_abnormal_bile_duct0.91437139
86MP0002752_abnormal_somatic_nervous0.90527488
87MP0000538_abnormal_urinary_bladder0.90206313
88MP0005171_absent_coat_pigmentation0.87686972
89MP0001529_abnormal_vocalization0.86984643
90MP0001502_abnormal_circadian_rhythm0.84408436
91MP0005332_abnormal_amino_acid0.82654614
92MP0001905_abnormal_dopamine_level0.81562587
93MP0001984_abnormal_olfaction0.79439879
94MP0003698_abnormal_male_reproductive0.79154943
95MP0002095_abnormal_skin_pigmentation0.78587967
96MP0000647_abnormal_sebaceous_gland0.77748319
97MP0008961_abnormal_basal_metabolism0.77204335
98MP0005365_abnormal_bile_salt0.75818565
99MP0002184_abnormal_innervation0.75806879
100MP0005448_abnormal_energy_balance0.75579176

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.61539459
2Abnormality of midbrain morphology (HP:0002418)4.36683246
3Molar tooth sign on MRI (HP:0002419)4.36683246
4Congenital stationary night blindness (HP:0007642)4.05496319
5Pancreatic fibrosis (HP:0100732)3.98223774
6Abnormality of alanine metabolism (HP:0010916)3.79663887
7Hyperalaninemia (HP:0003348)3.79663887
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.79663887
9Nephronophthisis (HP:0000090)3.74632050
10True hermaphroditism (HP:0010459)3.70962114
11Abnormality of the renal cortex (HP:0011035)3.62633202
12Type II lissencephaly (HP:0007260)3.55491010
13Birth length less than 3rd percentile (HP:0003561)3.51088561
14Attenuation of retinal blood vessels (HP:0007843)3.36212844
15Tubular atrophy (HP:0000092)3.34069112
16Hyperventilation (HP:0002883)3.32515496
17Abnormality of the renal medulla (HP:0100957)3.30812545
18Inability to walk (HP:0002540)3.11088974
19Abnormal drinking behavior (HP:0030082)3.02401591
20Polydipsia (HP:0001959)3.02401591
21Pendular nystagmus (HP:0012043)2.86812844
22Cystic liver disease (HP:0006706)2.83500219
23Large for gestational age (HP:0001520)2.78570885
24Abolished electroretinogram (ERG) (HP:0000550)2.74553102
25Medial flaring of the eyebrow (HP:0010747)2.72262790
26Decreased circulating renin level (HP:0003351)2.71537300
27Progressive inability to walk (HP:0002505)2.70673225
28Patellar aplasia (HP:0006443)2.67344172
29Chronic hepatic failure (HP:0100626)2.62779482
30Gaze-evoked nystagmus (HP:0000640)2.61256155
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.60912459
32Absent/shortened dynein arms (HP:0200106)2.60912459
33Severe muscular hypotonia (HP:0006829)2.60907058
34Cerebellar dysplasia (HP:0007033)2.60382547
35Congenital, generalized hypertrichosis (HP:0004540)2.56394861
36Protruding tongue (HP:0010808)2.55879021
37Genetic anticipation (HP:0003743)2.54687737
38Aplasia/Hypoplasia of the patella (HP:0006498)2.53742816
39Abnormality of the pons (HP:0007361)2.53641463
40Chorioretinal atrophy (HP:0000533)2.49773091
41Concave nail (HP:0001598)2.48800523
42Increased corneal curvature (HP:0100692)2.48085063
43Keratoconus (HP:0000563)2.48085063
44Hypoplasia of the pons (HP:0012110)2.46210751
45Lissencephaly (HP:0001339)2.45496832
46Decreased central vision (HP:0007663)2.38490376
47Renal cortical cysts (HP:0000803)2.33827620
48Progressive cerebellar ataxia (HP:0002073)2.33562852
49Polyuria (HP:0000103)2.32555568
50Sclerocornea (HP:0000647)2.32021770
51Furrowed tongue (HP:0000221)2.28441212
52Clumsiness (HP:0002312)2.20366504
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.18505364
54Bile duct proliferation (HP:0001408)2.16189423
55Abnormal biliary tract physiology (HP:0012439)2.16189423
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15532299
57Abnormal rod and cone electroretinograms (HP:0008323)2.14633571
58Congenital hepatic fibrosis (HP:0002612)2.12171847
59Febrile seizures (HP:0002373)2.07590308
60Gait imbalance (HP:0002141)2.05604862
61Broad-based gait (HP:0002136)2.04384703
62Abnormal respiratory motile cilium morphology (HP:0005938)2.02307510
63Abnormal respiratory epithelium morphology (HP:0012253)2.02307510
64Fair hair (HP:0002286)2.01711927
65Anencephaly (HP:0002323)2.01433421
66Bony spicule pigmentary retinopathy (HP:0007737)2.00209591
67Male pseudohermaphroditism (HP:0000037)1.96847712
68Hemiparesis (HP:0001269)1.96743404
69Aplasia/Hypoplasia of the tongue (HP:0010295)1.94046046
70Congenital primary aphakia (HP:0007707)1.93553960
71Partial agenesis of the corpus callosum (HP:0001338)1.90159575
72Hyperglycinuria (HP:0003108)1.88793266
73Breast hypoplasia (HP:0003187)1.88204412
74Abnormal urine output (HP:0012590)1.84834864
75Tachypnea (HP:0002789)1.82359125
76Optic disc pallor (HP:0000543)1.82169969
77Stomach cancer (HP:0012126)1.82140959
78Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81769502
79Pachygyria (HP:0001302)1.78013431
80Nephrogenic diabetes insipidus (HP:0009806)1.75211892
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74372567
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73896849
83Abnormal number of erythroid precursors (HP:0012131)1.72825586
84Rib fusion (HP:0000902)1.72451042
85Dyskinesia (HP:0100660)1.71980204
86Congenital sensorineural hearing impairment (HP:0008527)1.71645793
87Increased CSF lactate (HP:0002490)1.71093602
88Abnormality of renin-angiotensin system (HP:0000847)1.68365192
89Ketosis (HP:0001946)1.67128795
90Bilateral microphthalmos (HP:0007633)1.66801382
91Dandy-Walker malformation (HP:0001305)1.66549462
92Small hand (HP:0200055)1.65924573
93Mesangial abnormality (HP:0001966)1.65872667
94Ketoacidosis (HP:0001993)1.65351916
95Optic nerve hypoplasia (HP:0000609)1.64998786
96Widely spaced teeth (HP:0000687)1.64848373
97Type 2 muscle fiber atrophy (HP:0003554)1.64725070
98Bulbous nose (HP:0000414)1.64113514
99Abnormal ciliary motility (HP:0012262)1.63624154
100Genital tract atresia (HP:0001827)1.62036040

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.29546609
2BMPR1B3.91845234
3ADRBK23.85152896
4ACVR1B3.68631919
5WNK43.44195742
6ZAK3.23784152
7TLK12.89081292
8GRK12.48905676
9INSRR2.25427174
10PINK12.11363399
11WNK32.10605843
12DAPK21.98537330
13MAP4K21.97776861
14TGFBR11.84913672
15OXSR11.78763384
16NUAK11.77985781
17TAOK31.77971103
18MAPK131.71269207
19STK391.66706241
20PNCK1.64095229
21ADRBK11.63560309
22MAP3K41.54324064
23CASK1.42375887
24MKNK21.41341425
25CAMKK21.39642077
26MUSK1.37261326
27MAPK151.23245700
28TNIK1.14160940
29MAPKAPK31.13367005
30PRKCG1.06973131
31PIK3CA1.06496993
32NEK20.93530133
33PTK2B0.92964387
34MARK10.91990967
35MAP2K60.91491514
36MAPKAPK50.90429592
37MAP2K70.89099933
38TXK0.88103121
39PHKG10.85800535
40PHKG20.85800535
41DYRK20.84638295
42PRKCE0.81746036
43TIE10.79356743
44WEE10.77753862
45BRSK20.76849079
46SIK20.75274570
47PAK30.73345822
48NTRK30.71254788
49OBSCN0.69863170
50RPS6KA50.69402709
51CAMK1D0.68622393
52PRKCQ0.64389731
53VRK10.63657170
54NTRK20.62595628
55PKN10.61974057
56WNK10.61541001
57MKNK10.57909693
58STK38L0.57216559
59MAP2K10.55750424
60TRPM70.53708119
61PLK40.52005526
62RPS6KA60.51943431
63CAMK2A0.51813253
64IKBKB0.51786512
65PRKCI0.51493542
66BCKDK0.49176474
67STK110.48849633
68CAMK10.47414566
69CAMKK10.45875262
70PLK20.45682721
71FGFR20.44350047
72MAP2K40.43672297
73STK30.42541344
74CHUK0.42166298
75CSNK1G20.41071814
76PRKACA0.40980269
77AKT30.39996994
78CSNK1G10.39749188
79TEC0.39720892
80CSNK1D0.39517666
81TYRO30.39285148
82NLK0.38823436
83CAMK1G0.37967822
84IRAK10.37658102
85PRKAA10.36677105
86PRKAA20.36109397
87MAP2K20.34852832
88CHEK20.34306415
89FLT30.33707441
90PRKCA0.33264932
91LIMK10.33010725
92CSNK1A10.32919575
93NME10.32818439
94PLK30.31225973
95KIT0.29178648
96TRIM280.29176461
97PLK10.28975362
98PRKCH0.27534409
99CSNK1A1L0.26446387
100PRKG10.25773764

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.15202656
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.11571208
3Nitrogen metabolism_Homo sapiens_hsa009103.07126440
4Phototransduction_Homo sapiens_hsa047442.63422619
5Selenocompound metabolism_Homo sapiens_hsa004502.55058375
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.37929014
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.35637296
8Butanoate metabolism_Homo sapiens_hsa006502.35539162
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.32199030
10Tryptophan metabolism_Homo sapiens_hsa003802.10818826
11Nicotine addiction_Homo sapiens_hsa050332.06032747
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.05820997
13Ether lipid metabolism_Homo sapiens_hsa005652.03802600
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01520361
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95142560
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.94479926
17Oxidative phosphorylation_Homo sapiens_hsa001901.83032848
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.79770350
19Sulfur relay system_Homo sapiens_hsa041221.74388341
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.72168137
21Homologous recombination_Homo sapiens_hsa034401.70034373
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.54861148
23Caffeine metabolism_Homo sapiens_hsa002321.52333410
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48385544
25ABC transporters_Homo sapiens_hsa020101.40210403
26Taste transduction_Homo sapiens_hsa047421.39991165
27Morphine addiction_Homo sapiens_hsa050321.35914143
28Basal transcription factors_Homo sapiens_hsa030221.33511937
29RNA polymerase_Homo sapiens_hsa030201.32689696
30One carbon pool by folate_Homo sapiens_hsa006701.32275078
31Parkinsons disease_Homo sapiens_hsa050121.30300293
32Fanconi anemia pathway_Homo sapiens_hsa034601.29794121
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.26616454
34Arachidonic acid metabolism_Homo sapiens_hsa005901.25858991
35Cardiac muscle contraction_Homo sapiens_hsa042601.25185532
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.23289035
37Ovarian steroidogenesis_Homo sapiens_hsa049131.19885020
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18586347
39Olfactory transduction_Homo sapiens_hsa047401.18217897
40Peroxisome_Homo sapiens_hsa041461.11943303
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.08036123
42Chemical carcinogenesis_Homo sapiens_hsa052041.05012044
43Histidine metabolism_Homo sapiens_hsa003401.03000398
44RNA degradation_Homo sapiens_hsa030180.99412533
45Serotonergic synapse_Homo sapiens_hsa047260.98464549
46Circadian entrainment_Homo sapiens_hsa047130.98355196
47Glutamatergic synapse_Homo sapiens_hsa047240.97841549
48Fat digestion and absorption_Homo sapiens_hsa049750.96737701
49Insulin secretion_Homo sapiens_hsa049110.95473158
50Glycerolipid metabolism_Homo sapiens_hsa005610.92654740
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91028056
52GABAergic synapse_Homo sapiens_hsa047270.89910935
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89777457
54Protein export_Homo sapiens_hsa030600.88605177
55Propanoate metabolism_Homo sapiens_hsa006400.87863661
56Alzheimers disease_Homo sapiens_hsa050100.87167602
57Huntingtons disease_Homo sapiens_hsa050160.87008931
58Retinol metabolism_Homo sapiens_hsa008300.86276063
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85459432
60Calcium signaling pathway_Homo sapiens_hsa040200.85079701
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.84181116
62beta-Alanine metabolism_Homo sapiens_hsa004100.80291318
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80065899
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78709481
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69068458
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67029780
67Salivary secretion_Homo sapiens_hsa049700.64506458
68Mineral absorption_Homo sapiens_hsa049780.62311455
69Ribosome_Homo sapiens_hsa030100.62150720
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.61041668
71Regulation of autophagy_Homo sapiens_hsa041400.60847276
72Fatty acid biosynthesis_Homo sapiens_hsa000610.60779900
73Purine metabolism_Homo sapiens_hsa002300.55409964
74Metabolic pathways_Homo sapiens_hsa011000.55089181
75Sulfur metabolism_Homo sapiens_hsa009200.54778059
76Dorso-ventral axis formation_Homo sapiens_hsa043200.54093664
77Vitamin digestion and absorption_Homo sapiens_hsa049770.53819287
78Asthma_Homo sapiens_hsa053100.50182444
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49861815
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46818553
81Collecting duct acid secretion_Homo sapiens_hsa049660.46592157
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46003051
83Long-term depression_Homo sapiens_hsa047300.45616848
84Dopaminergic synapse_Homo sapiens_hsa047280.40079922
85Fatty acid degradation_Homo sapiens_hsa000710.39951943
86Basal cell carcinoma_Homo sapiens_hsa052170.39726625
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39156653
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.39069150
89Pyrimidine metabolism_Homo sapiens_hsa002400.38507700
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37370585
91Oxytocin signaling pathway_Homo sapiens_hsa049210.37116002
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.36046839
93Gastric acid secretion_Homo sapiens_hsa049710.34079656
94Bile secretion_Homo sapiens_hsa049760.32984496
95Hedgehog signaling pathway_Homo sapiens_hsa043400.32097821
96Steroid biosynthesis_Homo sapiens_hsa001000.31343333
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30263489
98Circadian rhythm_Homo sapiens_hsa047100.30197639
99cAMP signaling pathway_Homo sapiens_hsa040240.29883139
100Primary immunodeficiency_Homo sapiens_hsa053400.29462470

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