ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.40746815
2	DNA deamination (GO:0045006)	4.99356561
3	L-fucose catabolic process (GO:0042355)	3.96984851
4	fucose catabolic process (GO:0019317)	3.96984851
5	L-fucose metabolic process (GO:0042354)	3.96984851
6	water-soluble vitamin biosynthetic process (GO:0042364)	3.69472208
7	sulfation (GO:0051923)	3.67632690
8	indolalkylamine metabolic process (GO:0006586)	3.66716676
9	indole-containing compound catabolic process (GO:0042436)	3.64069127
10	indolalkylamine catabolic process (GO:0046218)	3.64069127
11	tryptophan catabolic process (GO:0006569)	3.64069127
12	preassembly of GPI anchor in ER membrane (GO:0016254)	3.58508629
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.57133737
14	NADH dehydrogenase complex assembly (GO:0010257)	3.57133737
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.57133737
16	kynurenine metabolic process (GO:0070189)	3.45763223
17	detection of light stimulus involved in sensory perception (GO:0050962)	3.41845243
18	detection of light stimulus involved in visual perception (GO:0050908)	3.41845243
19	protein complex biogenesis (GO:0070271)	3.41097665
20	somite development (GO:0061053)	3.36135988
21	negative regulation of mast cell activation (GO:0033004)	3.27955615
22	platelet dense granule organization (GO:0060155)	3.27854453
23	cornea development in camera-type eye (GO:0061303)	3.26968535
24	neural tube formation (GO:0001841)	3.24873540
25	protein polyglutamylation (GO:0018095)	3.23377235
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.19763943
27	response to pheromone (GO:0019236)	3.15554029
28	tryptophan metabolic process (GO:0006568)	3.07476470
29	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.04317311
30	negative regulation of telomere maintenance (GO:0032205)	3.03547260
31	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.03248226
32	protein K11-linked deubiquitination (GO:0035871)	3.00639231
33	axoneme assembly (GO:0035082)	2.93172536
34	indole-containing compound metabolic process (GO:0042430)	2.92618376
35	regulation of hippo signaling (GO:0035330)	2.87475739
36	piRNA metabolic process (GO:0034587)	2.87167524
37	mannosylation (GO:0097502)	2.86748594
38	gamma-aminobutyric acid transport (GO:0015812)	2.85561139
39	regulation of mesoderm development (GO:2000380)	2.85275320
40	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.85192528
41	regulation of action potential (GO:0098900)	2.84323017
42	cellular response to ATP (GO:0071318)	2.84313138
43	cell proliferation in forebrain (GO:0021846)	2.79860627
44	neuronal action potential (GO:0019228)	2.79403072
45	respiratory chain complex IV assembly (GO:0008535)	2.75221711
46	adaptation of signaling pathway (GO:0023058)	2.74693917
47	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.74528388
48	DNA methylation involved in gamete generation (GO:0043046)	2.73250429
49	protein localization to cilium (GO:0061512)	2.72603847
50	kidney morphogenesis (GO:0060993)	2.72115926
51	GPI anchor metabolic process (GO:0006505)	2.71064248
52	photoreceptor cell development (GO:0042461)	2.69618886
53	endoderm formation (GO:0001706)	2.68134702
54	cellular ketone body metabolic process (GO:0046950)	2.68104622
55	negative regulation of systemic arterial blood pressure (GO:0003085)	2.67721237
56	replication fork processing (GO:0031297)	2.67375315
57	embryonic epithelial tube formation (GO:0001838)	2.67365462
58	positive regulation of defense response to virus by host (GO:0002230)	2.65483794
59	dentate gyrus development (GO:0021542)	2.63944054
60	synaptic transmission, cholinergic (GO:0007271)	2.61526736
61	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.60420923
62	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.59656352
63	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.57606324
64	transmission of nerve impulse (GO:0019226)	2.57561693
65	positive regulation of fatty acid transport (GO:2000193)	2.57430352
66	reflex (GO:0060004)	2.56397679
67	ketone body metabolic process (GO:1902224)	2.54401724
68	primary amino compound metabolic process (GO:1901160)	2.52964724
69	epithelial cilium movement (GO:0003351)	2.52572283
70	prostate gland growth (GO:0060736)	2.52245075
71	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.52018967
72	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.52018967
73	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.51549514
74	cytochrome complex assembly (GO:0017004)	2.51370636
75	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.51352613
76	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.51352613
77	serotonin metabolic process (GO:0042428)	2.51038027
78	magnesium ion transport (GO:0015693)	2.49802630
79	cilium morphogenesis (GO:0060271)	2.48056208
80	double-strand break repair via homologous recombination (GO:0000724)	2.48006715
81	recombinational repair (GO:0000725)	2.47948530
82	photoreceptor cell maintenance (GO:0045494)	2.47545402
83	spinal cord motor neuron differentiation (GO:0021522)	2.46185931
84	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.45515481
85	retinal cone cell development (GO:0046549)	2.44683699
86	epithelial tube formation (GO:0072175)	2.43222846
87	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.43121577
88	eye photoreceptor cell development (GO:0042462)	2.42763644
89	dopamine transport (GO:0015872)	2.39194484
90	rRNA catabolic process (GO:0016075)	2.38916865
91	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.37795511
92	C-terminal protein lipidation (GO:0006501)	2.37664070
93	regulation of collateral sprouting (GO:0048670)	2.37601400
94	C-terminal protein amino acid modification (GO:0018410)	2.36790988
95	regulation of mitotic spindle checkpoint (GO:1903504)	2.36685409
96	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.36685409
97	nonmotile primary cilium assembly (GO:0035058)	2.35667953
98	rhodopsin mediated signaling pathway (GO:0016056)	2.35435555
99	protein prenylation (GO:0018342)	2.35058298
100	prenylation (GO:0097354)	2.35058298

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.87354462
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.37549257
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.06254559
4	VDR_22108803_ChIP-Seq_LS180_Human	2.83630099
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70393466
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.64349292
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.55140734
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.41711686
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.28587701
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.26149049
11	EWS_26573619_Chip-Seq_HEK293_Human	2.23792692
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.19820649
13	FUS_26573619_Chip-Seq_HEK293_Human	2.16051871
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.10482904
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.05086481
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.04893347
17	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.03689787
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.02802801
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.01856508
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99682351
21	P300_19829295_ChIP-Seq_ESCs_Human	1.98932812
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.96093590
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.84072466
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82347452
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71444934
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.69067040
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.67488703
28	* GABP_17652178_ChIP-ChIP_JURKAT_Human	1.65059632
29	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.62406280
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.60965936
31	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56062745
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53654066
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.52790142
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52635415
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52587969
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.52587969
37	* MYC_18940864_ChIP-ChIP_HL60_Human	1.49883360
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.49238784
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.48020487
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46114370
41	* STAT3_23295773_ChIP-Seq_U87_Human	1.44569219
42	TP53_22573176_ChIP-Seq_HFKS_Human	1.43581471
43	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43156633
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40519350
45	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.39197622
46	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.36259947
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35349594
48	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.34587207
49	TCF4_23295773_ChIP-Seq_U87_Human	1.33454543
50	AR_25329375_ChIP-Seq_VCAP_Human	1.33253729
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.32473443
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32055941
53	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30849228
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28193884
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28193884
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26520276
57	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25437060
58	VDR_23849224_ChIP-Seq_CD4+_Human	1.24967581
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22875230
60	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21328614
61	ELK1_19687146_ChIP-ChIP_HELA_Human	1.21306559
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19239464
63	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18742572
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.18325340
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17550566
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17129554
67	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16960185
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16960185
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.16895375
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16895375
71	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16778487
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16547392
73	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15421940
74	NCOR_22424771_ChIP-Seq_293T_Human	1.15114779
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14278224
76	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13390351
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12937005
78	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12870613
79	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09962446
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09508922
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09325939
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08577276
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08157317
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07720218
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05964896
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05424084
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04863466
88	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04445587
89	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.04135951
90	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03792732
91	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.03147524
92	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.02244186
93	AR_20517297_ChIP-Seq_VCAP_Human	0.98485337
94	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.97673827
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96432618
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96221341
97	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96195051
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93807888
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.93688497
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91914054

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.11730768
2	MP0003646_muscle_fatigue	2.69426202
3	MP0002102_abnormal_ear_morphology	2.64190896
4	MP0002837_dystrophic_cardiac_calcinosis	2.58552053
5	MP0000569_abnormal_digit_pigmentation	2.54820441
6	MP0005646_abnormal_pituitary_gland	2.52218091
7	MP0006292_abnormal_olfactory_placode	2.39834201
8	MP0006072_abnormal_retinal_apoptosis	2.32299318
9	MP0005551_abnormal_eye_electrophysiolog	2.23619677
10	MP0003787_abnormal_imprinting	2.20382785
11	MP0001968_abnormal_touch/_nociception	2.18477863
12	MP0003195_calcinosis	2.06349311
13	MP0000372_irregular_coat_pigmentation	2.02868621
14	MP0005253_abnormal_eye_physiology	1.91121834
15	MP0001986_abnormal_taste_sensitivity	1.88842577
16	MP0002736_abnormal_nociception_after	1.88639175
17	MP0005645_abnormal_hypothalamus_physiol	1.85683894
18	MP0009046_muscle_twitch	1.84113873
19	MP0004885_abnormal_endolymph	1.79950937
20	MP0008872_abnormal_physiological_respon	1.77818494
21	MP0002876_abnormal_thyroid_physiology	1.77533852
22	MP0002638_abnormal_pupillary_reflex	1.73189360
23	MP0009745_abnormal_behavioral_response	1.67929312
24	MP0000631_abnormal_neuroendocrine_gland	1.67224692
25	MP0004142_abnormal_muscle_tone	1.64288782
26	MP0002160_abnormal_reproductive_system	1.62191551
27	MP0000427_abnormal_hair_cycle	1.54985910
28	MP0005389_reproductive_system_phenotype	1.54728032
29	MP0005174_abnormal_tail_pigmentation	1.54243983
30	MP0001485_abnormal_pinna_reflex	1.53792816
31	MP0002272_abnormal_nervous_system	1.50571962
32	MP0002138_abnormal_hepatobiliary_system	1.44126945
33	MP0004043_abnormal_pH_regulation	1.43259316
34	MP0002735_abnormal_chemical_nociception	1.41144967
35	MP0002938_white_spotting	1.40506150
36	MP0003880_abnormal_central_pattern	1.39142432
37	MP0004133_heterotaxia	1.38156398
38	MP0006276_abnormal_autonomic_nervous	1.36088840
39	MP0001501_abnormal_sleep_pattern	1.33587087
40	MP0002234_abnormal_pharynx_morphology	1.31373907
41	MP0000383_abnormal_hair_follicle	1.29458499
42	MP0001984_abnormal_olfaction	1.29155476
43	MP0001486_abnormal_startle_reflex	1.28719639
44	MP0003718_maternal_effect	1.27461727
45	MP0004147_increased_porphyrin_level	1.25521190
46	MP0005084_abnormal_gallbladder_morpholo	1.23432995
47	MP0008058_abnormal_DNA_repair	1.22758344
48	MP0003011_delayed_dark_adaptation	1.22660909
49	MP0002163_abnormal_gland_morphology	1.19251221
50	MP0002653_abnormal_ependyma_morphology	1.18861728
51	MP0005075_abnormal_melanosome_morpholog	1.17470940
52	MP0002751_abnormal_autonomic_nervous	1.17036736
53	MP0001919_abnormal_reproductive_system	1.15588180
54	MP0008995_early_reproductive_senescence	1.15099645
55	MP0010386_abnormal_urinary_bladder	1.12468430
56	MP0003119_abnormal_digestive_system	1.12084421
57	MP0002928_abnormal_bile_duct	1.11610756
58	MP0004145_abnormal_muscle_electrophysio	1.11367439
59	MP0002557_abnormal_social/conspecific_i	1.09684666
60	MP0002572_abnormal_emotion/affect_behav	1.09438898
61	MP0001970_abnormal_pain_threshold	1.05089990
62	MP0005379_endocrine/exocrine_gland_phen	1.04880458
63	MP0005671_abnormal_response_to	1.03094661
64	MP0002064_seizures	1.02791319
65	MP0002733_abnormal_thermal_nociception	1.02717337
66	MP0008875_abnormal_xenobiotic_pharmacok	1.01998303
67	MP0005195_abnormal_posterior_eye	1.01907866
68	MP0002095_abnormal_skin_pigmentation	1.01879920
69	MP0005386_behavior/neurological_phenoty	0.99734866
70	MP0004924_abnormal_behavior	0.99734866
71	MP0008789_abnormal_olfactory_epithelium	0.97793006
72	MP0000516_abnormal_urinary_system	0.96756037
73	MP0005367_renal/urinary_system_phenotyp	0.96756037
74	MP0001905_abnormal_dopamine_level	0.95335043
75	MP0002184_abnormal_innervation	0.93883685
76	MP0003786_premature_aging	0.93688746
77	MP0003635_abnormal_synaptic_transmissio	0.93450312
78	MP0000049_abnormal_middle_ear	0.93217682
79	MP0003136_yellow_coat_color	0.92201510
80	MP0001529_abnormal_vocalization	0.91858134
81	MP0005410_abnormal_fertilization	0.88055278
82	MP0008775_abnormal_heart_ventricle	0.87487792
83	MP0002063_abnormal_learning/memory/cond	0.87249527
84	MP0002734_abnormal_mechanical_nocicepti	0.86477845
85	MP0002277_abnormal_respiratory_mucosa	0.86158560
86	MP0000647_abnormal_sebaceous_gland	0.85856826
87	MP0002752_abnormal_somatic_nervous	0.85109987
88	MP0004742_abnormal_vestibular_system	0.84508563
89	MP0002067_abnormal_sensory_capabilities	0.84371701
90	MP0000230_abnormal_systemic_arterial	0.84149511
91	MP0001764_abnormal_homeostasis	0.83241690
92	MP0003121_genomic_imprinting	0.79640220
93	MP0003937_abnormal_limbs/digits/tail_de	0.78874210
94	MP0000778_abnormal_nervous_system	0.77911854
95	MP0003252_abnormal_bile_duct	0.77338003
96	MP0001963_abnormal_hearing_physiology	0.76520043
97	MP0000015_abnormal_ear_pigmentation	0.76205032
98	MP0001324_abnormal_eye_pigmentation	0.75795369
99	MP0000026_abnormal_inner_ear	0.73542168
100	MP0004130_abnormal_muscle_cell	0.73108657

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.40193269
2	Congenital stationary night blindness (HP:0007642)	4.08968277
3	Pancreatic fibrosis (HP:0100732)	4.01248160
4	True hermaphroditism (HP:0010459)	3.81135412
5	Abnormality of midbrain morphology (HP:0002418)	3.61152078
6	Molar tooth sign on MRI (HP:0002419)	3.61152078
7	Nephronophthisis (HP:0000090)	3.43097610
8	Abolished electroretinogram (ERG) (HP:0000550)	3.00575900
9	Abnormality of the renal cortex (HP:0011035)	2.94793367
10	Pendular nystagmus (HP:0012043)	2.94005745
11	Attenuation of retinal blood vessels (HP:0007843)	2.90089685
12	Abnormality of the renal medulla (HP:0100957)	2.88599772
13	Type II lissencephaly (HP:0007260)	2.83921795
14	Medial flaring of the eyebrow (HP:0010747)	2.69375019
15	Genetic anticipation (HP:0003743)	2.59709797
16	Cystic liver disease (HP:0006706)	2.56368604
17	Gaze-evoked nystagmus (HP:0000640)	2.55748722
18	Chronic hepatic failure (HP:0100626)	2.54686019
19	Abnormal rod and cone electroretinograms (HP:0008323)	2.54217573
20	Renal cortical cysts (HP:0000803)	2.54192160
21	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.48797565
22	Hyperventilation (HP:0002883)	2.47900677
23	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.45833755
24	Progressive cerebellar ataxia (HP:0002073)	2.41986728
25	Keratoconus (HP:0000563)	2.37703176
26	Increased corneal curvature (HP:0100692)	2.37703176
27	Methylmalonic acidemia (HP:0002912)	2.35915951
28	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.29636809
29	Furrowed tongue (HP:0000221)	2.27103207
30	Acute necrotizing encephalopathy (HP:0006965)	2.23869359
31	Bony spicule pigmentary retinopathy (HP:0007737)	2.23525542
32	Decreased central vision (HP:0007663)	2.21659778
33	Sclerocornea (HP:0000647)	2.21051873
34	Broad-based gait (HP:0002136)	2.19018850
35	Chorioretinal atrophy (HP:0000533)	2.18753526
36	Anencephaly (HP:0002323)	2.13399436
37	Progressive inability to walk (HP:0002505)	2.12986207
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.11806154
39	Mitochondrial inheritance (HP:0001427)	2.11372396
40	Stomach cancer (HP:0012126)	2.11003592
41	Gait imbalance (HP:0002141)	2.10519473
42	Progressive macrocephaly (HP:0004481)	2.09485263
43	Methylmalonic aciduria (HP:0012120)	2.08707382
44	Tubular atrophy (HP:0000092)	2.08274763
45	Short tibia (HP:0005736)	2.07424616
46	Abnormality of the renal collecting system (HP:0004742)	2.07386140
47	Increased CSF lactate (HP:0002490)	2.06798108
48	Thyroiditis (HP:0100646)	2.06767929
49	Congenital primary aphakia (HP:0007707)	2.06288792
50	Lissencephaly (HP:0001339)	2.05336631
51	Abnormality of DNA repair (HP:0003254)	2.05077505
52	Congenital sensorineural hearing impairment (HP:0008527)	2.04786302
53	3-Methylglutaconic aciduria (HP:0003535)	2.04272281
54	Inability to walk (HP:0002540)	2.03168944
55	Male pseudohermaphroditism (HP:0000037)	2.03031403
56	Congenital, generalized hypertrichosis (HP:0004540)	2.02109715
57	Congenital hepatic fibrosis (HP:0002612)	2.00459408
58	Abnormality of alanine metabolism (HP:0010916)	1.98231231
59	Hyperalaninemia (HP:0003348)	1.98231231
60	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.98231231
61	Polydipsia (HP:0001959)	1.98037473
62	Abnormal drinking behavior (HP:0030082)	1.98037473
63	Short 1st metacarpal (HP:0010034)	1.97204261
64	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.97204261
65	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.97181407
66	Small hand (HP:0200055)	1.95879926
67	Abnormality of the pons (HP:0007361)	1.95528011
68	Abnormal biliary tract physiology (HP:0012439)	1.95294647
69	Bile duct proliferation (HP:0001408)	1.95294647
70	Hypoplasia of the pons (HP:0012110)	1.94481052
71	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.94155926
72	Acute encephalopathy (HP:0006846)	1.93549583
73	Nephrogenic diabetes insipidus (HP:0009806)	1.93259458
74	Agitation (HP:0000713)	1.92553848
75	Aplasia/Hypoplasia of the patella (HP:0006498)	1.91451340
76	Asplenia (HP:0001746)	1.89230517
77	Abnormal mitochondria in muscle tissue (HP:0008316)	1.87412363
78	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.87196408
79	Optic nerve hypoplasia (HP:0000609)	1.86230760
80	Postaxial foot polydactyly (HP:0001830)	1.84557556
81	Patellar aplasia (HP:0006443)	1.83797109
82	Pachygyria (HP:0001302)	1.83004529
83	Neoplasm of the adrenal cortex (HP:0100641)	1.82682038
84	Severe muscular hypotonia (HP:0006829)	1.82108429
85	Tachypnea (HP:0002789)	1.80676432
86	Aplasia/hypoplasia of the uterus (HP:0008684)	1.80418538
87	Genital tract atresia (HP:0001827)	1.80408905
88	Large for gestational age (HP:0001520)	1.80283241
89	Absent thumb (HP:0009777)	1.79509573
90	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.79464146
91	Cerebellar dysplasia (HP:0007033)	1.78993313
92	Optic disc pallor (HP:0000543)	1.77862821
93	Absent/shortened dynein arms (HP:0200106)	1.76020232
94	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.76020232
95	Vaginal atresia (HP:0000148)	1.74688588
96	Hemiparesis (HP:0001269)	1.71593273
97	IgG deficiency (HP:0004315)	1.71570115
98	Ketoacidosis (HP:0001993)	1.69490283
99	Ketosis (HP:0001946)	1.69386219
100	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.69211167

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.91757742
2	ADRBK2	2.94885598
3	ZAK	2.74239669
4	TAOK3	2.64268149
5	MAP4K2	2.61435883
6	BMPR1B	2.60987053
7	GRK1	2.60595281
8	WNK3	2.56632035
9	NUAK1	2.43940586
10	ACVR1B	2.31462898
11	TXK	2.30730830
12	TLK1	2.29814252
13	INSRR	1.99217566
14	MAP3K4	1.85887896
15	MAPK13	1.85614850
16	PINK1	1.81881508
17	CASK	1.81609900
18	WNK4	1.77479691
19	TRIM28	1.59909279
20	MKNK2	1.38851398
21	STK39	1.33005917
22	MAP2K7	1.31690929
23	OXSR1	1.29057022
24	TNIK	1.23705199
25	PLK2	1.21860071
26	GRK7	1.13511621
27	CSNK1G2	1.07401884
28	PAK3	1.05939005
29	ERBB3	1.03405285
30	BCKDK	1.03138791
31	ADRBK1	1.03114940
32	CSNK1G3	1.01857294
33	MARK1	1.00682644
34	CSNK1A1L	0.97634189
35	CSNK1G1	0.97158753
36	PIK3CA	0.96724157
37	VRK1	0.95112575
38	BCR	0.92863204
39	MUSK	0.91125420
40	DAPK2	0.90812821
41	CAMKK2	0.90391356
42	PRKCE	0.89239456
43	DYRK2	0.87191710
44	CDK19	0.82087769
45	BRSK2	0.80729907
46	TEC	0.78896870
47	EIF2AK3	0.78352972
48	PRKCG	0.76115213
49	MAPKAPK3	0.75586841
50	EPHA4	0.73240875
51	GRK5	0.71978703
52	IKBKB	0.67579649
53	NTRK3	0.67341128
54	AKT3	0.66219646
55	ITK	0.64217863
56	RPS6KA5	0.62500856
57	PTK2B	0.61725570
58	KIT	0.57701667
59	PHKG1	0.57504589
60	PHKG2	0.57504589
61	PRKCQ	0.56996180
62	STK38L	0.56718600
63	MKNK1	0.56230183
64	FGFR2	0.56126359
65	TGFBR1	0.53651954
66	CAMK2A	0.53024967
67	TIE1	0.50159760
68	MST4	0.49419959
69	DYRK3	0.48305309
70	ATR	0.48111912
71	SGK2	0.47423869
72	SYK	0.47205253
73	CSNK1A1	0.46937651
74	PKN1	0.45883207
75	PRKACA	0.45821613
76	STK11	0.45729204
77	TAF1	0.45725718
78	MARK3	0.42224854
79	FLT3	0.40717130
80	PIM1	0.40506627
81	PLK3	0.40379752
82	CHUK	0.39496693
83	IGF1R	0.38477125
84	PLK4	0.38052231
85	CSNK1D	0.38000163
86	PRKAA1	0.37946865
87	PRKCI	0.36939311
88	NTRK2	0.36080027
89	MAPKAPK5	0.35415416
90	OBSCN	0.35023683
91	SRPK1	0.34085821
92	PLK1	0.33998177
93	TGFBR2	0.33045365
94	IKBKE	0.33014254
95	CHEK2	0.32534778
96	ABL1	0.31882134
97	STK16	0.31641201
98	ATM	0.31223349
99	MAP2K6	0.31202051
100	PRKCA	0.30618694

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.19295631
2	Phototransduction_Homo sapiens_hsa04744	2.67332734
3	Nicotine addiction_Homo sapiens_hsa05033	2.31271628
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.19506594
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.17327352
6	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.15662255
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.09645028
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.03558605
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.02305271
10	Selenocompound metabolism_Homo sapiens_hsa00450	1.97794814
11	RNA polymerase_Homo sapiens_hsa03020	1.96505920
12	Butanoate metabolism_Homo sapiens_hsa00650	1.96317016
13	Homologous recombination_Homo sapiens_hsa03440	1.94037605
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.89764735
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.89547452
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.88078006
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.87656283
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.86956429
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.82368514
20	Basal transcription factors_Homo sapiens_hsa03022	1.81680406
21	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.76409815
22	Protein export_Homo sapiens_hsa03060	1.71824676
23	Sulfur metabolism_Homo sapiens_hsa00920	1.65254159
24	Taste transduction_Homo sapiens_hsa04742	1.64587557
25	RNA degradation_Homo sapiens_hsa03018	1.57664459
26	Caffeine metabolism_Homo sapiens_hsa00232	1.54709873
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.47873434
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.45299736
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.44548180
30	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.40341593
31	Morphine addiction_Homo sapiens_hsa05032	1.32261570
32	Parkinsons disease_Homo sapiens_hsa05012	1.30451145
33	Primary immunodeficiency_Homo sapiens_hsa05340	1.30023036
34	Regulation of autophagy_Homo sapiens_hsa04140	1.25059729
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.20698938
36	Olfactory transduction_Homo sapiens_hsa04740	1.20487256
37	Peroxisome_Homo sapiens_hsa04146	1.19868130
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.19137456
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18046352
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.12234578
41	Non-homologous end-joining_Homo sapiens_hsa03450	1.11467260
42	Retinol metabolism_Homo sapiens_hsa00830	1.07944863
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.05116380
44	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.01679580
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.98798537
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.96520916
47	GABAergic synapse_Homo sapiens_hsa04727	0.95791216
48	Asthma_Homo sapiens_hsa05310	0.95314141
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.93877359
50	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.92062650
51	Alzheimers disease_Homo sapiens_hsa05010	0.91864829
52	Serotonergic synapse_Homo sapiens_hsa04726	0.90668541
53	Propanoate metabolism_Homo sapiens_hsa00640	0.89859403
54	Circadian entrainment_Homo sapiens_hsa04713	0.87942034
55	Huntingtons disease_Homo sapiens_hsa05016	0.87493249
56	Insulin secretion_Homo sapiens_hsa04911	0.85706978
57	Type I diabetes mellitus_Homo sapiens_hsa04940	0.85135226
58	ABC transporters_Homo sapiens_hsa02010	0.83691205
59	One carbon pool by folate_Homo sapiens_hsa00670	0.83329286
60	Glutamatergic synapse_Homo sapiens_hsa04724	0.82951212
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.81901089
62	Graft-versus-host disease_Homo sapiens_hsa05332	0.78046820
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76940703
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75362270
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75227619
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72888812
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72776777
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.72581472
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.69373708
70	Proteasome_Homo sapiens_hsa03050	0.67871284
71	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67723308
72	Cardiac muscle contraction_Homo sapiens_hsa04260	0.67578964
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.65122853
74	Purine metabolism_Homo sapiens_hsa00230	0.64143012
75	Calcium signaling pathway_Homo sapiens_hsa04020	0.63863061
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.63006355
77	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.61809930
78	Allograft rejection_Homo sapiens_hsa05330	0.60822811
79	Salivary secretion_Homo sapiens_hsa04970	0.59462761
80	Nucleotide excision repair_Homo sapiens_hsa03420	0.57192289
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56385509
82	Circadian rhythm_Homo sapiens_hsa04710	0.53508480
83	Metabolic pathways_Homo sapiens_hsa01100	0.52933291
84	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.51333108
85	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.49556951
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47973018
87	Dopaminergic synapse_Homo sapiens_hsa04728	0.45335017
88	Sulfur relay system_Homo sapiens_hsa04122	0.44946053
89	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44528515
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43874025
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.40185033
92	RNA transport_Homo sapiens_hsa03013	0.39746845
93	Steroid biosynthesis_Homo sapiens_hsa00100	0.38918831
94	Alcoholism_Homo sapiens_hsa05034	0.37709486
95	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.37241213
96	Rheumatoid arthritis_Homo sapiens_hsa05323	0.36645119
97	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36637790
98	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.32794796
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.32370001
100	Cholinergic synapse_Homo sapiens_hsa04725	0.32346759

ZNF557

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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