ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nonmotile primary cilium assembly (GO:0035058)	4.48005185
2	L-fucose catabolic process (GO:0042355)	4.20491994
3	fucose catabolic process (GO:0019317)	4.20491994
4	L-fucose metabolic process (GO:0042354)	4.20491994
5	response to pheromone (GO:0019236)	4.02103464
6	neural tube formation (GO:0001841)	3.66133904
7	behavioral response to nicotine (GO:0035095)	3.65262959
8	axoneme assembly (GO:0035082)	3.62083213
9	cornea development in camera-type eye (GO:0061303)	3.57687965
10	protein K11-linked deubiquitination (GO:0035871)	3.54560310
11	pyrimidine nucleobase catabolic process (GO:0006208)	3.50458988
12	protein localization to cilium (GO:0061512)	3.45067185
13	cilium morphogenesis (GO:0060271)	3.36894733
14	presynaptic membrane assembly (GO:0097105)	3.36106269
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.35208727
16	hindbrain development (GO:0030902)	3.34358428
17	negative regulation of neurological system process (GO:0031645)	3.26055906
18	regulation of hexokinase activity (GO:1903299)	3.26007456
19	regulation of glucokinase activity (GO:0033131)	3.26007456
20	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.24875545
21	prostate gland growth (GO:0060736)	3.24510614
22	head development (GO:0060322)	3.24341651
23	epithelial cilium movement (GO:0003351)	3.18895815
24	retinal ganglion cell axon guidance (GO:0031290)	3.17091617
25	nucleobase catabolic process (GO:0046113)	3.15991988
26	postsynaptic membrane organization (GO:0001941)	3.13616698
27	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.09641554
28	cilium organization (GO:0044782)	3.09461633
29	platelet dense granule organization (GO:0060155)	3.08647857
30	adaptation of signaling pathway (GO:0023058)	3.01194276
31	cilium assembly (GO:0042384)	3.00759140
32	photoreceptor cell maintenance (GO:0045494)	3.00462691
33	protein polyglutamylation (GO:0018095)	2.98784111
34	preassembly of GPI anchor in ER membrane (GO:0016254)	2.98683628
35	DNA double-strand break processing (GO:0000729)	2.96683044
36	limb bud formation (GO:0060174)	2.94711389
37	limb development (GO:0060173)	2.91726251
38	appendage development (GO:0048736)	2.91726251
39	reflex (GO:0060004)	2.89353749
40	negative regulation of mast cell activation (GO:0033004)	2.89156523
41	indole-containing compound catabolic process (GO:0042436)	2.87889466
42	indolalkylamine catabolic process (GO:0046218)	2.87889466
43	tryptophan catabolic process (GO:0006569)	2.87889466
44	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.87213941
45	indolalkylamine metabolic process (GO:0006586)	2.84708362
46	somite development (GO:0061053)	2.84529109
47	DNA methylation involved in gamete generation (GO:0043046)	2.83508605
48	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.82944963
49	kynurenine metabolic process (GO:0070189)	2.82698270
50	startle response (GO:0001964)	2.80469807
51	microtubule severing (GO:0051013)	2.80143592
52	inner ear receptor stereocilium organization (GO:0060122)	2.79798203
53	glycosphingolipid biosynthetic process (GO:0006688)	2.77302822
54	neuron cell-cell adhesion (GO:0007158)	2.76742600
55	presynaptic membrane organization (GO:0097090)	2.75184914
56	protein-cofactor linkage (GO:0018065)	2.74782990
57	piRNA metabolic process (GO:0034587)	2.72241075
58	activated T cell proliferation (GO:0050798)	2.72077439
59	auditory receptor cell stereocilium organization (GO:0060088)	2.69608704
60	regulation of cilium movement (GO:0003352)	2.68798287
61	magnesium ion transport (GO:0015693)	2.67460347
62	regulation of respiratory system process (GO:0044065)	2.67309610
63	photoreceptor cell development (GO:0042461)	2.66454931
64	cilium movement (GO:0003341)	2.65929650
65	GPI anchor metabolic process (GO:0006505)	2.65800041
66	intraciliary transport (GO:0042073)	2.63854913
67	somite rostral/caudal axis specification (GO:0032525)	2.62832385
68	reciprocal meiotic recombination (GO:0007131)	2.61237983
69	reciprocal DNA recombination (GO:0035825)	2.61237983
70	retinal cone cell development (GO:0046549)	2.60661784
71	embryonic epithelial tube formation (GO:0001838)	2.60213724
72	ubiquinone metabolic process (GO:0006743)	2.59565440
73	respiratory chain complex IV assembly (GO:0008535)	2.59007627
74	glycerophospholipid catabolic process (GO:0046475)	2.58560415
75	negative regulation of telomere maintenance (GO:0032205)	2.56587285
76	histone mRNA catabolic process (GO:0071044)	2.56125080
77	regulation of telomere maintenance (GO:0032204)	2.53875604
78	water-soluble vitamin biosynthetic process (GO:0042364)	2.52969212
79	ubiquinone biosynthetic process (GO:0006744)	2.51272065
80	nephron tubule morphogenesis (GO:0072078)	2.50209452
81	nephron epithelium morphogenesis (GO:0072088)	2.50209452
82	C4-dicarboxylate transport (GO:0015740)	2.49862900
83	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.48888281
84	histone H2A ubiquitination (GO:0033522)	2.48604064
85	tryptophan metabolic process (GO:0006568)	2.47219004
86	positive regulation of mitochondrial fission (GO:0090141)	2.47074844
87	inositol phosphate catabolic process (GO:0071545)	2.46341512
88	establishment of protein localization to Golgi (GO:0072600)	2.46007181
89	eye photoreceptor cell development (GO:0042462)	2.44954063
90	anterograde synaptic vesicle transport (GO:0048490)	2.43957607
91	brain morphogenesis (GO:0048854)	2.43667536
92	forebrain morphogenesis (GO:0048853)	2.43287520
93	negative regulation of axon guidance (GO:1902668)	2.42635229
94	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.42154569
95	histone H2A acetylation (GO:0043968)	2.42112417
96	mechanosensory behavior (GO:0007638)	2.41962027
97	gamma-aminobutyric acid transport (GO:0015812)	2.41563996
98	dendritic spine morphogenesis (GO:0060997)	2.39922369
99	cilium or flagellum-dependent cell motility (GO:0001539)	2.38373638
100	protein localization to synapse (GO:0035418)	2.37164231

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.94786235
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.42670325
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.28404001
4	VDR_22108803_ChIP-Seq_LS180_Human	3.22862031
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.07776519
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.90395441
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.80832536
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.75655913
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.75535382
10	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.51303916
11	EWS_26573619_Chip-Seq_HEK293_Human	2.37925483
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.36020647
13	FUS_26573619_Chip-Seq_HEK293_Human	2.28084100
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.22071737
15	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16375488
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00676344
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.98949890
18	P300_19829295_ChIP-Seq_ESCs_Human	1.98448507
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.96635102
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.91201133
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.87920398
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.86667953
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.77961858
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.72351447
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.70544923
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.69420888
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.68206411
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.66481113
29	STAT3_23295773_ChIP-Seq_U87_Human	1.65621642
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64208104
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.63621510
32	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.62724804
33	* CBP_20019798_ChIP-Seq_JUKART_Human	1.62724804
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.61088206
35	TCF4_23295773_ChIP-Seq_U87_Human	1.55678197
36	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54882588
37	AR_25329375_ChIP-Seq_VCAP_Human	1.53583298
38	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.52763179
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.48327336
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46626641
41	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.44622549
42	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.43011337
43	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.42300979
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41346691
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.41346691
46	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40248660
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39925438
48	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.38363851
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.38257567
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37023923
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34237259
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.33956005
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32992530
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.32557943
55	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.32497585
56	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.32117046
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31143049
58	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30570157
59	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.29899581
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27861664
61	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.27400840
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26707308
63	AR_21572438_ChIP-Seq_LNCaP_Human	1.23905007
64	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22471907
65	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21210660
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20812762
67	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20523311
68	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18572801
69	MYC_18940864_ChIP-ChIP_HL60_Human	1.17141436
70	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.16833774
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16497530
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16497530
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15950666
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12813724
75	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.12096875
76	REST_21632747_ChIP-Seq_MESCs_Mouse	1.11643005
77	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.10685373
78	ELK1_19687146_ChIP-ChIP_HELA_Human	1.10244203
79	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.09504586
80	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08698552
81	TCF4_22108803_ChIP-Seq_LS180_Human	1.07536042
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06393473
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05624854
84	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04919871
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04688245
86	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04463183
87	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.04227934
88	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.04013281
89	VDR_23849224_ChIP-Seq_CD4+_Human	1.02954383
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.02091243
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01923840
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01923840
93	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.01781097
94	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00609849
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99965769
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99881261
97	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99364768
98	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98516960
99	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.97033624
100	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.96687184

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.99433097
2	MP0002102_abnormal_ear_morphology	4.01280671
3	MP0008877_abnormal_DNA_methylation	2.60138966
4	MP0002653_abnormal_ependyma_morphology	2.39861438
5	MP0000427_abnormal_hair_cycle	2.37979473
6	MP0003787_abnormal_imprinting	2.37579744
7	MP0001984_abnormal_olfaction	2.37205195
8	MP0006072_abnormal_retinal_apoptosis	2.32143449
9	MP0008789_abnormal_olfactory_epithelium	2.21038600
10	MP0000383_abnormal_hair_follicle	2.17991314
11	MP0005551_abnormal_eye_electrophysiolog	2.17917807
12	MP0003880_abnormal_central_pattern	2.01383860
13	MP0005253_abnormal_eye_physiology	1.97206546
14	MP0005394_taste/olfaction_phenotype	1.87807562
15	MP0005499_abnormal_olfactory_system	1.87807562
16	MP0002638_abnormal_pupillary_reflex	1.85934217
17	MP0005645_abnormal_hypothalamus_physiol	1.85724584
18	MP0002234_abnormal_pharynx_morphology	1.83074610
19	MP0001986_abnormal_taste_sensitivity	1.77515439
20	MP0006292_abnormal_olfactory_placode	1.77004813
21	MP0008872_abnormal_physiological_respon	1.64235444
22	MP0004142_abnormal_muscle_tone	1.64234975
23	MP0000778_abnormal_nervous_system	1.61454018
24	MP0001968_abnormal_touch/_nociception	1.59996682
25	MP0003122_maternal_imprinting	1.56542051
26	MP0005646_abnormal_pituitary_gland	1.56151584
27	MP0004147_increased_porphyrin_level	1.54306755
28	MP0000631_abnormal_neuroendocrine_gland	1.54035694
29	MP0010678_abnormal_skin_adnexa	1.51306304
30	MP0010386_abnormal_urinary_bladder	1.48420630
31	MP0002272_abnormal_nervous_system	1.44762984
32	MP0003121_genomic_imprinting	1.43684716
33	MP0001486_abnormal_startle_reflex	1.42866935
34	MP0001502_abnormal_circadian_rhythm	1.42672983
35	MP0001501_abnormal_sleep_pattern	1.42263465
36	MP0002751_abnormal_autonomic_nervous	1.39953602
37	MP0002557_abnormal_social/conspecific_i	1.33915051
38	MP0006276_abnormal_autonomic_nervous	1.33626291
39	MP0008057_abnormal_DNA_replication	1.33274323
40	MP0003195_calcinosis	1.31136667
41	MP0001529_abnormal_vocalization	1.30145278
42	MP0002736_abnormal_nociception_after	1.28580460
43	MP0004043_abnormal_pH_regulation	1.28365029
44	MP0004742_abnormal_vestibular_system	1.26204383
45	MP0009745_abnormal_behavioral_response	1.23988723
46	MP0002233_abnormal_nose_morphology	1.22676046
47	MP0002009_preneoplasia	1.20298624
48	MP0000647_abnormal_sebaceous_gland	1.19911215
49	MP0003937_abnormal_limbs/digits/tail_de	1.18475116
50	MP0002735_abnormal_chemical_nociception	1.18227978
51	MP0002938_white_spotting	1.17989533
52	MP0009046_muscle_twitch	1.17798508
53	MP0002928_abnormal_bile_duct	1.16868256
54	MP0002572_abnormal_emotion/affect_behav	1.16387203
55	MP0002837_dystrophic_cardiac_calcinosis	1.15848289
56	MP0001293_anophthalmia	1.15302099
57	MP0004885_abnormal_endolymph	1.15029680
58	MP0003938_abnormal_ear_development	1.14174125
59	MP0003890_abnormal_embryonic-extraembry	1.11997054
60	MP0008995_early_reproductive_senescence	1.09653400
61	MP0002063_abnormal_learning/memory/cond	1.08485018
62	MP0002184_abnormal_innervation	1.07869759
63	MP0001970_abnormal_pain_threshold	1.05190559
64	MP0005391_vision/eye_phenotype	1.02977504
65	MP0004134_abnormal_chest_morphology	1.02100128
66	MP0002067_abnormal_sensory_capabilities	1.01880280
67	MP0002163_abnormal_gland_morphology	1.00617202
68	MP0000026_abnormal_inner_ear	1.00175934
69	MP0003646_muscle_fatigue	0.99865046
70	MP0004924_abnormal_behavior	0.97927718
71	MP0005386_behavior/neurological_phenoty	0.97927718
72	MP0004133_heterotaxia	0.97681007
73	MP0002752_abnormal_somatic_nervous	0.96682562
74	MP0002095_abnormal_skin_pigmentation	0.95834713
75	MP0002822_catalepsy	0.93253947
76	MP0005085_abnormal_gallbladder_physiolo	0.92917430
77	MP0003635_abnormal_synaptic_transmissio	0.90965939
78	MP0002733_abnormal_thermal_nociception	0.88761212
79	MP0005195_abnormal_posterior_eye	0.85892722
80	MP0001270_distended_abdomen	0.85804215
81	MP0003718_maternal_effect	0.85456306
82	MP0000516_abnormal_urinary_system	0.84515338
83	MP0005367_renal/urinary_system_phenotyp	0.84515338
84	MP0005171_absent_coat_pigmentation	0.83280671
85	MP0005174_abnormal_tail_pigmentation	0.81161174
86	MP0005084_abnormal_gallbladder_morpholo	0.80445688
87	MP0003136_yellow_coat_color	0.80167466
88	MP0002160_abnormal_reproductive_system	0.79698944
89	MP0001485_abnormal_pinna_reflex	0.79533529
90	MP0002064_seizures	0.77794607
91	MP0002282_abnormal_trachea_morphology	0.77725746
92	MP0001756_abnormal_urination	0.77640998
93	MP0000955_abnormal_spinal_cord	0.76973057
94	MP0008875_abnormal_xenobiotic_pharmacok	0.76682938
95	MP0002909_abnormal_adrenal_gland	0.76436970
96	MP0001905_abnormal_dopamine_level	0.76094990
97	MP0002069_abnormal_eating/drinking_beha	0.75969402
98	MP0010329_abnormal_lipoprotein_level	0.75960808
99	MP0002277_abnormal_respiratory_mucosa	0.75549632
100	MP0005389_reproductive_system_phenotype	0.74507702

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nephronophthisis (HP:0000090)	4.34560707
2	Pancreatic cysts (HP:0001737)	4.16722582
3	Molar tooth sign on MRI (HP:0002419)	4.16334719
4	Abnormality of midbrain morphology (HP:0002418)	4.16334719
5	Medial flaring of the eyebrow (HP:0010747)	4.04626889
6	Pancreatic fibrosis (HP:0100732)	3.68537701
7	Abnormality of the renal medulla (HP:0100957)	3.68422696
8	True hermaphroditism (HP:0010459)	3.67792534
9	Gait imbalance (HP:0002141)	3.50694617
10	Nephrogenic diabetes insipidus (HP:0009806)	3.46831798
11	Congenital primary aphakia (HP:0007707)	3.46176348
12	Tubular atrophy (HP:0000092)	3.41141046
13	Abnormality of the renal cortex (HP:0011035)	3.35676460
14	Congenital stationary night blindness (HP:0007642)	3.11494988
15	Hypothermia (HP:0002045)	3.07772820
16	Hyperventilation (HP:0002883)	3.07695956
17	Attenuation of retinal blood vessels (HP:0007843)	3.07421665
18	Chronic hepatic failure (HP:0100626)	3.00868042
19	Type II lissencephaly (HP:0007260)	2.90153769
20	Abnormal drinking behavior (HP:0030082)	2.74075552
21	Polydipsia (HP:0001959)	2.74075552
22	Lissencephaly (HP:0001339)	2.73106874
23	Large for gestational age (HP:0001520)	2.72634204
24	Genital tract atresia (HP:0001827)	2.72081348
25	Abolished electroretinogram (ERG) (HP:0000550)	2.71728071
26	Renal cortical cysts (HP:0000803)	2.67554816
27	Vaginal atresia (HP:0000148)	2.66001478
28	Poor coordination (HP:0002370)	2.61922187
29	Cerebellar dysplasia (HP:0007033)	2.58861431
30	Cystic liver disease (HP:0006706)	2.56821019
31	Intestinal atresia (HP:0011100)	2.52895371
32	Increased corneal curvature (HP:0100692)	2.49381198
33	Keratoconus (HP:0000563)	2.49381198
34	Fair hair (HP:0002286)	2.49198634
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.48978112
36	Pendular nystagmus (HP:0012043)	2.47368303
37	Hemiparesis (HP:0001269)	2.41593271
38	Oligodactyly (hands) (HP:0001180)	2.40369694
39	Postaxial hand polydactyly (HP:0001162)	2.38706988
40	Retinal dysplasia (HP:0007973)	2.34676291
41	Colon cancer (HP:0003003)	2.27175561
42	Tubulointerstitial nephritis (HP:0001970)	2.24461656
43	Broad-based gait (HP:0002136)	2.24225878
44	Pachygyria (HP:0001302)	2.22004505
45	Thyroiditis (HP:0100646)	2.20767191
46	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.18223349
47	Optic nerve hypoplasia (HP:0000609)	2.15153694
48	Anencephaly (HP:0002323)	2.14061821
49	Decreased central vision (HP:0007663)	2.12273896
50	Postaxial foot polydactyly (HP:0001830)	2.11548731
51	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.10989960
52	Abnormal biliary tract physiology (HP:0012439)	2.10692888
53	Bile duct proliferation (HP:0001408)	2.10692888
54	Inability to walk (HP:0002540)	2.09823665
55	Congenital hepatic fibrosis (HP:0002612)	2.09653342
56	Aplasia/hypoplasia of the uterus (HP:0008684)	2.08892204
57	Progressive inability to walk (HP:0002505)	2.07961714
58	Polyuria (HP:0000103)	2.04078421
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.03962332
60	Sclerocornea (HP:0000647)	2.00825417
61	Protruding tongue (HP:0010808)	1.99960461
62	Febrile seizures (HP:0002373)	1.99030258
63	Prominent nasal bridge (HP:0000426)	1.98358753
64	Specific learning disability (HP:0001328)	1.96577391
65	Aplasia/Hypoplasia of the lens (HP:0008063)	1.96134754
66	Narrow forehead (HP:0000341)	1.93514683
67	Severe muscular hypotonia (HP:0006829)	1.92958409
68	Bony spicule pigmentary retinopathy (HP:0007737)	1.92352059
69	Stomach cancer (HP:0012126)	1.92187427
70	Tubulointerstitial abnormality (HP:0001969)	1.89996163
71	Widely spaced teeth (HP:0000687)	1.89550244
72	Abnormality of the labia minora (HP:0012880)	1.89512857
73	Hypoplasia of the uterus (HP:0000013)	1.88683951
74	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.87780717
75	Clumsiness (HP:0002312)	1.86792714
76	Oculomotor apraxia (HP:0000657)	1.86094938
77	Neonatal respiratory distress (HP:0002643)	1.84374702
78	Broad foot (HP:0001769)	1.82890772
79	Agitation (HP:0000713)	1.82508532
80	Dialeptic seizures (HP:0011146)	1.80880477
81	Retinitis pigmentosa (HP:0000510)	1.80175905
82	Tented upper lip vermilion (HP:0010804)	1.78365331
83	Focal motor seizures (HP:0011153)	1.76575555
84	Oligodactyly (HP:0012165)	1.75526626
85	Short tibia (HP:0005736)	1.75049066
86	Focal seizures (HP:0007359)	1.74738809
87	Genetic anticipation (HP:0003743)	1.74125257
88	Exotropia (HP:0000577)	1.73564245
89	Short foot (HP:0001773)	1.73342331
90	Furrowed tongue (HP:0000221)	1.71698760
91	Aqueductal stenosis (HP:0002410)	1.71598332
92	Methylmalonic acidemia (HP:0002912)	1.71020975
93	Astigmatism (HP:0000483)	1.71011402
94	Absent speech (HP:0001344)	1.70958299
95	Abnormality of the parathyroid morphology (HP:0011766)	1.70832125
96	Hip dysplasia (HP:0001385)	1.69308506
97	Decreased testicular size (HP:0008734)	1.69216304
98	Patellar aplasia (HP:0006443)	1.67278409
99	Generalized hypopigmentation of hair (HP:0011358)	1.66731806
100	Dyskinesia (HP:0100660)	1.65361907

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.87934370
2	MAP4K2	3.11781845
3	ADRBK2	2.86575527
4	CASK	2.84242592
5	NLK	2.64223644
6	TAOK3	2.57804641
7	ERBB3	2.50889572
8	WNK3	2.37379222
9	MAP3K4	2.27451742
10	EPHA3	2.18772472
11	BMPR1B	2.13348976
12	MAPK13	2.05241856
13	TXK	1.97283458
14	NUAK1	1.95764119
15	CSNK1G1	1.83634608
16	GRK1	1.77130550
17	MARK1	1.76944012
18	BCKDK	1.69008706
19	PINK1	1.67946901
20	BCR	1.67423192
21	BRD4	1.60411988
22	TRIM28	1.40168000
23	CSNK1A1L	1.38679680
24	EPHA4	1.37518370
25	STK38L	1.37104168
26	CSNK1G2	1.36691764
27	ACVR1B	1.30817113
28	CSNK1G3	1.28537900
29	FGFR2	1.20665522
30	TNIK	1.19840794
31	CAMKK2	1.17140435
32	STK39	1.15211684
33	SGK2	1.09073904
34	OXSR1	1.06938096
35	WNK4	1.05958086
36	MAP3K2	1.03304002
37	MAP2K7	1.01149501
38	NTRK2	1.00700377
39	MST4	0.99015684
40	MKNK1	0.98453495
41	RPS6KA4	0.98337926
42	PRKCE	0.98107127
43	BMPR2	0.96683355
44	BRSK2	0.95302158
45	LATS1	0.93433577
46	NTRK3	0.89390853
47	STK3	0.88523350
48	IRAK1	0.85407715
49	ZAK	0.85227063
50	PLK2	0.84249154
51	PAK3	0.84170351
52	INSRR	0.83532233
53	DYRK2	0.81913663
54	SGK223	0.76801554
55	SGK494	0.76801554
56	ADRBK1	0.75832057
57	DYRK1A	0.75645100
58	PTK2B	0.69398259
59	FER	0.67381730
60	TLK1	0.65733233
61	RPS6KA5	0.64977820
62	MKNK2	0.64707768
63	TGFBR1	0.62623622
64	PRKCG	0.59090396
65	STK11	0.57823095
66	PIK3CG	0.57794003
67	SRPK1	0.55469213
68	MAP3K7	0.54411652
69	PKN1	0.53344397
70	PHKG1	0.53235191
71	PHKG2	0.53235191
72	CHUK	0.53001004
73	MAPKAPK3	0.51229714
74	PASK	0.50061467
75	EPHB1	0.49143856
76	MAPK15	0.49100111
77	CSNK1A1	0.48974454
78	NEK2	0.48936257
79	MAPKAPK5	0.47567772
80	LMTK2	0.47376527
81	CSNK1D	0.42983679
82	FLT3	0.40049142
83	TEC	0.39777769
84	ITK	0.39515305
85	NME1	0.39318198
86	CDK3	0.38638713
87	SGK3	0.38032401
88	CAMK2A	0.37394543
89	IKBKE	0.35985616
90	CAMKK1	0.35875814
91	IKBKB	0.35058474
92	PRKAA1	0.33838038
93	DAPK2	0.33632893
94	PNCK	0.32799077
95	PRKCQ	0.32178183
96	MUSK	0.32013882
97	MAP2K2	0.30929479
98	AKT3	0.30908811
99	TNK2	0.29764567
100	PIK3CA	0.29148594

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.28189448
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.23997504
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.76434997
4	Butanoate metabolism_Homo sapiens_hsa00650	2.71925576
5	Nicotine addiction_Homo sapiens_hsa05033	2.71720215
6	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.42729784
7	Basal transcription factors_Homo sapiens_hsa03022	2.37071059
8	Protein export_Homo sapiens_hsa03060	2.35149716
9	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.26804313
10	Ether lipid metabolism_Homo sapiens_hsa00565	2.21988980
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.21659051
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.14574194
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.07680847
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.05651959
15	Selenocompound metabolism_Homo sapiens_hsa00450	2.03131212
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.02583972
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.01577888
18	Circadian rhythm_Homo sapiens_hsa04710	1.92376997
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.83098100
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.75937775
21	Regulation of autophagy_Homo sapiens_hsa04140	1.73105175
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.69500127
23	Propanoate metabolism_Homo sapiens_hsa00640	1.67335662
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.66313014
25	RNA degradation_Homo sapiens_hsa03018	1.64297108
26	RNA polymerase_Homo sapiens_hsa03020	1.53606447
27	Taste transduction_Homo sapiens_hsa04742	1.52545213
28	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.50889337
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.46820039
30	ABC transporters_Homo sapiens_hsa02010	1.39073671
31	Olfactory transduction_Homo sapiens_hsa04740	1.37494859
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34691611
33	Morphine addiction_Homo sapiens_hsa05032	1.34083876
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.32497016
35	GABAergic synapse_Homo sapiens_hsa04727	1.30251472
36	Circadian entrainment_Homo sapiens_hsa04713	1.29322977
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.24041981
38	Peroxisome_Homo sapiens_hsa04146	1.18861696
39	Glutamatergic synapse_Homo sapiens_hsa04724	1.14184139
40	Collecting duct acid secretion_Homo sapiens_hsa04966	1.12610406
41	Homologous recombination_Homo sapiens_hsa03440	1.02166467
42	Long-term depression_Homo sapiens_hsa04730	1.01673707
43	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.01203057
44	Lysine degradation_Homo sapiens_hsa00310	0.98656280
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.98622757
46	Steroid biosynthesis_Homo sapiens_hsa00100	0.93971214
47	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.93372165
48	Serotonergic synapse_Homo sapiens_hsa04726	0.84967619
49	Dopaminergic synapse_Homo sapiens_hsa04728	0.84642372
50	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.84375886
51	Oxidative phosphorylation_Homo sapiens_hsa00190	0.84051987
52	Sphingolipid metabolism_Homo sapiens_hsa00600	0.81408317
53	Caffeine metabolism_Homo sapiens_hsa00232	0.77249130
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.73211688
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.70125283
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65775839
57	Insulin secretion_Homo sapiens_hsa04911	0.61716935
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60777492
59	Cocaine addiction_Homo sapiens_hsa05030	0.59361873
60	Salivary secretion_Homo sapiens_hsa04970	0.59233497
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57993714
62	Amphetamine addiction_Homo sapiens_hsa05031	0.57806975
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.57544988
64	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.57152865
65	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.56743298
66	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.55966970
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.55946906
68	Non-homologous end-joining_Homo sapiens_hsa03450	0.54154028
69	Primary immunodeficiency_Homo sapiens_hsa05340	0.52256407
70	Fatty acid elongation_Homo sapiens_hsa00062	0.51779320
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51462590
72	Axon guidance_Homo sapiens_hsa04360	0.50036544
73	Basal cell carcinoma_Homo sapiens_hsa05217	0.49418677
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44674440
75	Metabolic pathways_Homo sapiens_hsa01100	0.42971492
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.42188113
77	Retinol metabolism_Homo sapiens_hsa00830	0.41169368
78	FoxO signaling pathway_Homo sapiens_hsa04068	0.40750604
79	Parkinsons disease_Homo sapiens_hsa05012	0.40135202
80	One carbon pool by folate_Homo sapiens_hsa00670	0.39670751
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.39517068
82	Hippo signaling pathway_Homo sapiens_hsa04390	0.35695551
83	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34709530
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.34618989
85	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.33899367
86	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.32599392
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32073812
88	Purine metabolism_Homo sapiens_hsa00230	0.31769704
89	Ras signaling pathway_Homo sapiens_hsa04014	0.31251352
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.30878168
91	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.29740419
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.28551853
93	mTOR signaling pathway_Homo sapiens_hsa04150	0.27300237
94	Type II diabetes mellitus_Homo sapiens_hsa04930	0.25099637
95	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.24564327
96	Histidine metabolism_Homo sapiens_hsa00340	0.24313605
97	cAMP signaling pathway_Homo sapiens_hsa04024	0.24169590
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.23926693
99	Cholinergic synapse_Homo sapiens_hsa04725	0.23905719
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.23612736

ZNF558

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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