ZNF559

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neural tube formation (GO:0001841)4.94802353
2response to pheromone (GO:0019236)4.44106987
3DNA double-strand break processing (GO:0000729)4.31420590
4negative regulation of telomere maintenance (GO:0032205)3.83703217
5neurotransmitter-gated ion channel clustering (GO:0072578)3.80288846
6protein localization to cilium (GO:0061512)3.80202393
7behavioral response to nicotine (GO:0035095)3.69973361
8intraciliary transport (GO:0042073)3.54959161
9regulation of cytokine production involved in inflammatory response (GO:1900015)3.54542210
10platelet dense granule organization (GO:0060155)3.47250532
11nonmotile primary cilium assembly (GO:0035058)3.47066016
12regulation of telomere maintenance (GO:0032204)3.44242158
13pyrimidine nucleobase catabolic process (GO:0006208)3.40308898
14fucose catabolic process (GO:0019317)3.34315209
15L-fucose metabolic process (GO:0042354)3.34315209
16L-fucose catabolic process (GO:0042355)3.34315209
17detection of light stimulus involved in visual perception (GO:0050908)3.30696554
18detection of light stimulus involved in sensory perception (GO:0050962)3.30696554
19behavioral response to ethanol (GO:0048149)3.28419171
20signal peptide processing (GO:0006465)3.28027397
21regulation of action potential (GO:0098900)3.26637730
22DNA deamination (GO:0045006)3.22510798
23detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.19707604
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14296144
25piRNA metabolic process (GO:0034587)3.09316263
26negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.08331817
27negative regulation of translation, ncRNA-mediated (GO:0040033)3.08331817
28regulation of translation, ncRNA-mediated (GO:0045974)3.08331817
29indolalkylamine metabolic process (GO:0006586)3.08095195
30regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.07293634
31presynaptic membrane assembly (GO:0097105)3.07293630
32cilium morphogenesis (GO:0060271)3.03364625
33dentate gyrus development (GO:0021542)3.02116001
34adaptation of signaling pathway (GO:0023058)2.96734450
35tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94610856
36RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94610856
37replication fork processing (GO:0031297)2.94425311
38regulation of cilium movement (GO:0003352)2.91557735
39retinal cone cell development (GO:0046549)2.88369826
40cilium organization (GO:0044782)2.86450985
41nucleobase catabolic process (GO:0046113)2.85381870
42epithelial cilium movement (GO:0003351)2.84995728
43tryptophan catabolic process (GO:0006569)2.84664384
44indole-containing compound catabolic process (GO:0042436)2.84664384
45indolalkylamine catabolic process (GO:0046218)2.84664384
46preassembly of GPI anchor in ER membrane (GO:0016254)2.84590443
47negative regulation of mast cell activation (GO:0033004)2.84386111
48kidney morphogenesis (GO:0060993)2.83970764
49cilium assembly (GO:0042384)2.82757547
50protein polyglutamylation (GO:0018095)2.82477717
51kynurenine metabolic process (GO:0070189)2.82019349
52water-soluble vitamin biosynthetic process (GO:0042364)2.80832648
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.80703250
54limb bud formation (GO:0060174)2.79272556
55centriole replication (GO:0007099)2.77994904
56DNA integration (GO:0015074)2.76721921
57branched-chain amino acid catabolic process (GO:0009083)2.74937131
58axoneme assembly (GO:0035082)2.72322672
59reflex (GO:0060004)2.71955330
60cullin deneddylation (GO:0010388)2.71591657
61prenylation (GO:0097354)2.70336921
62protein prenylation (GO:0018342)2.70336921
63regulation of relaxation of muscle (GO:1901077)2.69701478
64regulation of telomere maintenance via telomerase (GO:0032210)2.69016630
65postreplication repair (GO:0006301)2.68756109
66L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68566991
67regulation of collateral sprouting (GO:0048670)2.67996581
68dopamine transport (GO:0015872)2.67088163
69glycosphingolipid biosynthetic process (GO:0006688)2.65752763
70ubiquinone biosynthetic process (GO:0006744)2.64774290
71ubiquinone metabolic process (GO:0006743)2.64290494
72regulation of penile erection (GO:0060405)2.62374599
73photoreceptor cell maintenance (GO:0045494)2.61919364
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60078739
75mechanosensory behavior (GO:0007638)2.59308075
76protein complex biogenesis (GO:0070271)2.58957774
77respiratory chain complex IV assembly (GO:0008535)2.55727673
78regulation of timing of cell differentiation (GO:0048505)2.54353603
79negative regulation of transcription regulatory region DNA binding (GO:2000678)2.52433422
80regulation of hexokinase activity (GO:1903299)2.51606909
81regulation of glucokinase activity (GO:0033131)2.51606909
82protein K11-linked deubiquitination (GO:0035871)2.50799866
83gamma-aminobutyric acid transport (GO:0015812)2.50484500
84seminiferous tubule development (GO:0072520)2.50123496
85somite development (GO:0061053)2.49396744
86regulation of development, heterochronic (GO:0040034)2.48174909
87inositol phosphate catabolic process (GO:0071545)2.48099515
88regulation of sarcomere organization (GO:0060297)2.48091894
89histone H3-K9 methylation (GO:0051567)2.47842712
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.47708746
91presynaptic membrane organization (GO:0097090)2.47540029
92embryonic epithelial tube formation (GO:0001838)2.46580296
93establishment of protein localization to Golgi (GO:0072600)2.45742407
94recombinational repair (GO:0000725)2.45609052
95negative regulation of sodium ion transport (GO:0010766)2.44561621
96DNA catabolic process, exonucleolytic (GO:0000738)2.44517150
97tryptophan metabolic process (GO:0006568)2.43435239
98double-strand break repair via homologous recombination (GO:0000724)2.41922049
99postsynaptic membrane organization (GO:0001941)2.41252699
100cytochrome complex assembly (GO:0017004)2.40832721

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.52510338
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.22018409
3IGF1R_20145208_ChIP-Seq_DFB_Human3.20414235
4VDR_22108803_ChIP-Seq_LS180_Human3.16794563
5GBX2_23144817_ChIP-Seq_PC3_Human2.94471190
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.93235492
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.89178834
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.77946101
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72570985
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.64497848
11TAF15_26573619_Chip-Seq_HEK293_Human2.59481936
12FUS_26573619_Chip-Seq_HEK293_Human2.41483019
13EWS_26573619_Chip-Seq_HEK293_Human2.34088103
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26035384
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20208450
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18235478
17P300_19829295_ChIP-Seq_ESCs_Human2.17510668
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13194153
19EZH2_22144423_ChIP-Seq_EOC_Human2.09705943
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07146342
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98696348
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91924540
23ER_23166858_ChIP-Seq_MCF-7_Human1.80745808
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79437409
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.67896491
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67461130
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64722463
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61756408
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61368325
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61363607
31SMAD4_21799915_ChIP-Seq_A2780_Human1.60458820
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59316909
33CBP_20019798_ChIP-Seq_JUKART_Human1.58901324
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58901324
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56111770
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.53079616
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52726297
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51966186
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50519488
40STAT3_23295773_ChIP-Seq_U87_Human1.49367660
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.48659872
42ELK1_19687146_ChIP-ChIP_HELA_Human1.46911991
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.45608761
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45441725
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44087564
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43393924
47TCF4_23295773_ChIP-Seq_U87_Human1.43094689
48AR_25329375_ChIP-Seq_VCAP_Human1.42990941
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42097010
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.41711442
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.41316621
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.37556901
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36518946
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36450332
55TP53_22573176_ChIP-Seq_HFKS_Human1.35323663
56BCAT_22108803_ChIP-Seq_LS180_Human1.34654819
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33963165
58TCF4_22108803_ChIP-Seq_LS180_Human1.32236731
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29935147
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29935147
61P53_22387025_ChIP-Seq_ESCs_Mouse1.27016407
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26831898
63RUNX2_22187159_ChIP-Seq_PCA_Human1.25777897
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25069437
65NANOG_19829295_ChIP-Seq_ESCs_Human1.24636603
66SOX2_19829295_ChIP-Seq_ESCs_Human1.24636603
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23576451
68IRF1_19129219_ChIP-ChIP_H3396_Human1.22449246
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21678869
70VDR_23849224_ChIP-Seq_CD4+_Human1.21655461
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.20105361
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.19867365
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.19807598
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19250741
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18413435
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17939639
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17561013
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.15735133
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15274103
80P300_18555785_Chip-Seq_ESCs_Mouse1.15077145
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.13657715
82RNF2_27304074_Chip-Seq_NSC_Mouse1.11845432
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.11799148
84* MYC_18940864_ChIP-ChIP_HL60_Human1.11152780
85STAT3_18555785_Chip-Seq_ESCs_Mouse1.09316800
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07839492
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06599456
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.05784140
89FOXA1_25329375_ChIP-Seq_VCAP_Human1.05010950
90FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05010950
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.04832661
92SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03583691
93* TP63_19390658_ChIP-ChIP_HaCaT_Human1.02469642
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01695859
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.00128799
96TP53_16413492_ChIP-PET_HCT116_Human1.00031977
97OCT4_18555785_Chip-Seq_ESCs_Mouse0.99725606
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99526812
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98958023
100NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97670488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.01930783
2MP0002102_abnormal_ear_morphology3.08047047
3MP0000569_abnormal_digit_pigmentation2.97598392
4MP0008877_abnormal_DNA_methylation2.93562561
5MP0001529_abnormal_vocalization2.57282745
6MP0006072_abnormal_retinal_apoptosis2.49866274
7MP0003787_abnormal_imprinting2.46858649
8MP0006292_abnormal_olfactory_placode2.43397191
9MP0005551_abnormal_eye_electrophysiolog2.26789767
10MP0001968_abnormal_touch/_nociception2.23864400
11MP0002736_abnormal_nociception_after2.11244660
12MP0005253_abnormal_eye_physiology2.02093157
13MP0006276_abnormal_autonomic_nervous1.97338429
14MP0004885_abnormal_endolymph1.83588448
15MP0003195_calcinosis1.80956031
16MP0000372_irregular_coat_pigmentation1.79419098
17MP0003121_genomic_imprinting1.72527934
18MP0002095_abnormal_skin_pigmentation1.72449923
19MP0001984_abnormal_olfaction1.69883094
20MP0005645_abnormal_hypothalamus_physiol1.69804083
21MP0005084_abnormal_gallbladder_morpholo1.69700049
22MP0002638_abnormal_pupillary_reflex1.68646988
23MP0002837_dystrophic_cardiac_calcinosis1.64137559
24MP0005174_abnormal_tail_pigmentation1.59167945
25MP0002254_reproductive_system_inflammat1.58956360
26MP0008789_abnormal_olfactory_epithelium1.58584839
27MP0001486_abnormal_startle_reflex1.58576060
28MP0005075_abnormal_melanosome_morpholog1.55215792
29MP0008058_abnormal_DNA_repair1.55068612
30MP0004043_abnormal_pH_regulation1.52604804
31MP0001986_abnormal_taste_sensitivity1.52196105
32MP0002751_abnormal_autonomic_nervous1.50334475
33MP0002272_abnormal_nervous_system1.50294493
34MP0002928_abnormal_bile_duct1.47981751
35MP0008995_early_reproductive_senescence1.46849662
36MP0009745_abnormal_behavioral_response1.43870585
37MP0004142_abnormal_muscle_tone1.43042000
38MP0005646_abnormal_pituitary_gland1.42379030
39MP0000778_abnormal_nervous_system1.40551241
40MP0005187_abnormal_penis_morphology1.38428883
41MP0008872_abnormal_physiological_respon1.36342455
42MP0000427_abnormal_hair_cycle1.35465436
43MP0000647_abnormal_sebaceous_gland1.33677171
44MP0001485_abnormal_pinna_reflex1.30623721
45MP0003136_yellow_coat_color1.30230264
46MP0004147_increased_porphyrin_level1.28912291
47MP0001188_hyperpigmentation1.24307961
48MP0008875_abnormal_xenobiotic_pharmacok1.21842008
49MP0005394_taste/olfaction_phenotype1.21569830
50MP0005499_abnormal_olfactory_system1.21569830
51MP0002735_abnormal_chemical_nociception1.21069466
52MP0000631_abnormal_neuroendocrine_gland1.20732206
53MP0003718_maternal_effect1.17071218
54MP0004924_abnormal_behavior1.15293399
55MP0005386_behavior/neurological_phenoty1.15293399
56MP0000516_abnormal_urinary_system1.13671059
57MP0005367_renal/urinary_system_phenotyp1.13671059
58MP0010386_abnormal_urinary_bladder1.11410595
59MP0003122_maternal_imprinting1.10497737
60MP0009046_muscle_twitch1.10413410
61MP0002572_abnormal_emotion/affect_behav1.08464329
62MP0003011_delayed_dark_adaptation1.07769006
63MP0002557_abnormal_social/conspecific_i1.07552020
64MP0003635_abnormal_synaptic_transmissio1.07311432
65MP0002138_abnormal_hepatobiliary_system1.05475566
66MP0002822_catalepsy1.04727906
67MP0002938_white_spotting1.02817620
68MP0005423_abnormal_somatic_nervous1.01281448
69MP0001501_abnormal_sleep_pattern1.01249030
70MP0006054_spinal_hemorrhage1.00114971
71MP0002067_abnormal_sensory_capabilities0.98599209
72MP0001764_abnormal_homeostasis0.96519992
73MP0003567_abnormal_fetal_cardiomyocyte0.96359446
74MP0001905_abnormal_dopamine_level0.95393345
75MP0002063_abnormal_learning/memory/cond0.93771010
76MP0004215_abnormal_myocardial_fiber0.93153244
77MP0002876_abnormal_thyroid_physiology0.93086642
78MP0005195_abnormal_posterior_eye0.92986854
79MP0009697_abnormal_copulation0.91563607
80MP0002234_abnormal_pharynx_morphology0.90652865
81MP0001970_abnormal_pain_threshold0.85959506
82MP0003252_abnormal_bile_duct0.85920785
83MP0002184_abnormal_innervation0.85607133
84MP0002752_abnormal_somatic_nervous0.84798117
85MP0005220_abnormal_exocrine_pancreas0.84266490
86MP0003937_abnormal_limbs/digits/tail_de0.82714466
87MP0004484_altered_response_of0.81869599
88MP0001293_anophthalmia0.81175033
89MP0002064_seizures0.80746200
90MP0003698_abnormal_male_reproductive0.80394818
91MP0004133_heterotaxia0.79243782
92MP0005671_abnormal_response_to0.79080113
93MP0004859_abnormal_synaptic_plasticity0.78207018
94MP0005391_vision/eye_phenotype0.77720446
95MP0008775_abnormal_heart_ventricle0.75119148
96MP0000015_abnormal_ear_pigmentation0.74820140
97MP0000653_abnormal_sex_gland0.74601756
98MP0002733_abnormal_thermal_nociception0.73618828
99MP0001929_abnormal_gametogenesis0.73135666
100MP0000049_abnormal_middle_ear0.72524058

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.98003256
2Medial flaring of the eyebrow (HP:0010747)3.76379285
3Pancreatic fibrosis (HP:0100732)3.69852098
4Molar tooth sign on MRI (HP:0002419)3.69081016
5Abnormality of midbrain morphology (HP:0002418)3.69081016
6Nephronophthisis (HP:0000090)3.60925476
7True hermaphroditism (HP:0010459)3.60906546
8Progressive inability to walk (HP:0002505)3.21008931
9Abnormality of the renal medulla (HP:0100957)3.11513576
10Gait imbalance (HP:0002141)3.09524049
11Congenital primary aphakia (HP:0007707)3.07442170
12Hyperventilation (HP:0002883)3.01078388
13Type II lissencephaly (HP:0007260)3.00379651
14Methylmalonic acidemia (HP:0002912)2.91877222
15Congenital stationary night blindness (HP:0007642)2.88234060
16Abnormality of the renal cortex (HP:0011035)2.86178921
17Abolished electroretinogram (ERG) (HP:0000550)2.81786799
18Nephrogenic diabetes insipidus (HP:0009806)2.79632225
19Inability to walk (HP:0002540)2.79567085
20Absent speech (HP:0001344)2.69879479
21Postaxial foot polydactyly (HP:0001830)2.68638828
22Hyperglycinemia (HP:0002154)2.64550885
23Renal cortical cysts (HP:0000803)2.62749555
24Genital tract atresia (HP:0001827)2.60508516
25Chronic hepatic failure (HP:0100626)2.54443708
26Vaginal atresia (HP:0000148)2.50771446
27Cerebellar dysplasia (HP:0007033)2.48936404
28Colon cancer (HP:0003003)2.43528760
29Fair hair (HP:0002286)2.42153431
30Bile duct proliferation (HP:0001408)2.41987621
31Abnormal biliary tract physiology (HP:0012439)2.41987621
32Intestinal atresia (HP:0011100)2.39559171
33Hypoproteinemia (HP:0003075)2.38443068
34Tubulointerstitial nephritis (HP:0001970)2.37315488
35Postaxial hand polydactyly (HP:0001162)2.30924199
36Thyroiditis (HP:0100646)2.29390740
37Cystic liver disease (HP:0006706)2.26612151
38Hypothermia (HP:0002045)2.24430207
39Lissencephaly (HP:0001339)2.20073152
40Congenital hepatic fibrosis (HP:0002612)2.19793618
41Attenuation of retinal blood vessels (HP:0007843)2.19022639
42Broad-based gait (HP:0002136)2.18091887
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.15322705
44Abnormality of the labia minora (HP:0012880)2.15086599
45Gaze-evoked nystagmus (HP:0000640)2.14869464
46Poor coordination (HP:0002370)2.14119047
47Methylmalonic aciduria (HP:0012120)2.11432880
48Progressive cerebellar ataxia (HP:0002073)2.08255822
49Lipid accumulation in hepatocytes (HP:0006561)2.08070621
50Median cleft lip (HP:0000161)2.07476957
51Tubular atrophy (HP:0000092)2.06883615
52Drooling (HP:0002307)2.05220666
53Retinal dysplasia (HP:0007973)2.04536967
54Sclerocornea (HP:0000647)2.03514066
55Hemiparesis (HP:0001269)2.01262534
56Aplasia/Hypoplasia of the tongue (HP:0010295)1.98983657
57Widely spaced teeth (HP:0000687)1.97923689
58Abnormal rod and cone electroretinograms (HP:0008323)1.97499633
59Increased hepatocellular lipid droplets (HP:0006565)1.95775428
60Anencephaly (HP:0002323)1.94992563
61Abnormal drinking behavior (HP:0030082)1.93886996
62Polydipsia (HP:0001959)1.93886996
63Aplasia/Hypoplasia of the uvula (HP:0010293)1.93296890
64Volvulus (HP:0002580)1.88180382
65Amyotrophic lateral sclerosis (HP:0007354)1.87072492
66Abnormality of serine family amino acid metabolism (HP:0010894)1.86844795
67Abnormality of glycine metabolism (HP:0010895)1.86844795
68Hyperglycinuria (HP:0003108)1.86724351
69Severe muscular hypotonia (HP:0006829)1.85870812
70Excessive salivation (HP:0003781)1.85852633
71Pendular nystagmus (HP:0012043)1.85631510
72Febrile seizures (HP:0002373)1.84907506
73Mitochondrial inheritance (HP:0001427)1.81635658
74Specific learning disability (HP:0001328)1.81179813
75Hyperalaninemia (HP:0003348)1.79337117
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79337117
77Abnormality of alanine metabolism (HP:0010916)1.79337117
78Narrow forehead (HP:0000341)1.79288055
79Increased CSF lactate (HP:0002490)1.79227859
80Protruding tongue (HP:0010808)1.79094131
81Hypoplasia of the pons (HP:0012110)1.78622674
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77867579
83Aganglionic megacolon (HP:0002251)1.77563224
84Severe combined immunodeficiency (HP:0004430)1.77298690
85Hypoplasia of the fovea (HP:0007750)1.76898064
86Aplasia/Hypoplasia of the fovea (HP:0008060)1.76898064
87Small hand (HP:0200055)1.76715988
88Pachygyria (HP:0001302)1.75377292
89Short tibia (HP:0005736)1.73534085
90Oculomotor apraxia (HP:0000657)1.73293205
91Astigmatism (HP:0000483)1.72824501
92Tubulointerstitial abnormality (HP:0001969)1.72608475
93Broad foot (HP:0001769)1.71735878
94Panhypogammaglobulinemia (HP:0003139)1.71177610
95Decreased central vision (HP:0007663)1.70490916
96Concave nail (HP:0001598)1.69575767
97Constricted visual fields (HP:0001133)1.69361412
98Genetic anticipation (HP:0003743)1.69350894
99Generalized hypopigmentation of hair (HP:0011358)1.68275066
100Abnormality of the pons (HP:0007361)1.67430402

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.91026331
2WNK34.30644211
3MAP4K23.47149964
4TRIM282.48075016
5MAP3K42.45234689
6PINK12.30783356
7BMPR1B2.26713511
8BCR2.26565996
9MAPK132.14559261
10BCKDK1.96094104
11ZAK1.94952913
12ACVR1B1.86222191
13NUAK11.81063481
14ADRBK21.80022059
15MARK11.78352649
16CASK1.70906247
17MAP2K71.69428593
18GRK11.62986212
19TAOK31.59684107
20TXK1.58112017
21OXSR11.56662735
22STK391.53412994
23WNK41.45210008
24PAK31.32689261
25TNIK1.27188724
26NEK11.20414381
27CCNB11.19968790
28ERBB31.18438358
29DAPK21.16922494
30CSNK1G21.10952503
31EPHA31.07492458
32CSNK1G11.06329832
33MKNK11.02943632
34CSNK1G31.00457898
35MKNK20.96084318
36VRK10.92969531
37CSNK1A1L0.91042558
38PRKCE0.89675104
39EIF2AK30.89237460
40SRPK10.88680696
41TLK10.87914154
42DYRK20.87871905
43EPHA40.87593736
44INSRR0.85948917
45SIK30.85878108
46MST40.85133762
47PLK20.83541916
48KSR10.82917437
49PLK30.81777231
50DYRK30.75035563
51TNK20.73526883
52MINK10.72772777
53NTRK20.70609070
54NTRK30.68209107
55PRKCG0.67487819
56CDK190.64873299
57PKN10.63998522
58TEC0.63235399
59CAMKK20.63227408
60TGFBR10.62114299
61PTK2B0.61773018
62ADRBK10.61702720
63SGK20.60526832
64RPS6KB10.59816984
65KIT0.58856238
66STK160.58503963
67PIK3CA0.57264253
68FGFR20.54760208
69RPS6KA40.54716308
70TIE10.52339285
71CDK30.50146511
72BRSK20.50000921
73ATR0.48948870
74FER0.48686620
75BRD40.47001326
76PHKG10.46383846
77PHKG20.46383846
78CAMK2A0.43884340
79CSNK1A10.43191626
80CSNK1D0.41588268
81MAP2K60.39590179
82CAMK2D0.38822595
83CLK10.38681725
84PRKACA0.37879991
85IKBKB0.36937626
86IRAK10.36533965
87NLK0.36457499
88MAP2K40.36163286
89STK110.36153412
90STK38L0.35947652
91ATM0.35285159
92DYRK1A0.34412105
93PRKACB0.33931876
94PRKCQ0.33610736
95PRKG10.33146090
96FLT30.33069886
97SGK4940.30240659
98SGK2230.30240659
99PLK10.29660334
100PRKCZ0.29656009

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.26499629
2Phototransduction_Homo sapiens_hsa047442.85488163
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.84542568
4Propanoate metabolism_Homo sapiens_hsa006402.54032127
5Protein export_Homo sapiens_hsa030602.47351044
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42650899
7Basal transcription factors_Homo sapiens_hsa030222.32036708
8Fanconi anemia pathway_Homo sapiens_hsa034602.28364370
9Nicotine addiction_Homo sapiens_hsa050332.26174364
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18290091
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13854391
12Butanoate metabolism_Homo sapiens_hsa006502.10908503
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.92961012
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91553479
15Linoleic acid metabolism_Homo sapiens_hsa005911.91440914
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.90288991
17Homologous recombination_Homo sapiens_hsa034401.82916237
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74137091
19Nitrogen metabolism_Homo sapiens_hsa009101.72129885
20RNA polymerase_Homo sapiens_hsa030201.70493343
21Olfactory transduction_Homo sapiens_hsa047401.67231908
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65112200
23Ether lipid metabolism_Homo sapiens_hsa005651.58113930
24Regulation of autophagy_Homo sapiens_hsa041401.50417558
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48839770
26RNA degradation_Homo sapiens_hsa030181.48562431
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46300853
28Non-homologous end-joining_Homo sapiens_hsa034501.43958188
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.42988688
30Oxidative phosphorylation_Homo sapiens_hsa001901.40245149
31Taste transduction_Homo sapiens_hsa047421.37954852
32Parkinsons disease_Homo sapiens_hsa050121.34211721
33Peroxisome_Homo sapiens_hsa041461.27142659
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26350235
35Tryptophan metabolism_Homo sapiens_hsa003801.25834731
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.19750594
37Circadian entrainment_Homo sapiens_hsa047131.15736413
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13842158
39GABAergic synapse_Homo sapiens_hsa047271.11074101
40Primary immunodeficiency_Homo sapiens_hsa053401.07685614
41Morphine addiction_Homo sapiens_hsa050321.06384430
42Selenocompound metabolism_Homo sapiens_hsa004501.03858254
43Steroid biosynthesis_Homo sapiens_hsa001000.99991296
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95514767
45Dopaminergic synapse_Homo sapiens_hsa047280.93931366
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91391926
47Glutamatergic synapse_Homo sapiens_hsa047240.88824536
48Amphetamine addiction_Homo sapiens_hsa050310.87272111
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85556010
50Asthma_Homo sapiens_hsa053100.84345234
51Arachidonic acid metabolism_Homo sapiens_hsa005900.83637624
52Insulin secretion_Homo sapiens_hsa049110.83398009
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.83060139
54Chemical carcinogenesis_Homo sapiens_hsa052040.81523132
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81488477
56Huntingtons disease_Homo sapiens_hsa050160.79394993
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79103910
58Nucleotide excision repair_Homo sapiens_hsa034200.78406304
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75918853
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75874393
61Serotonergic synapse_Homo sapiens_hsa047260.74958143
62Dorso-ventral axis formation_Homo sapiens_hsa043200.71284479
63Mismatch repair_Homo sapiens_hsa034300.68231412
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66967414
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.65516322
66Retinol metabolism_Homo sapiens_hsa008300.65034474
67Purine metabolism_Homo sapiens_hsa002300.64412242
68Graft-versus-host disease_Homo sapiens_hsa053320.62385635
69Salivary secretion_Homo sapiens_hsa049700.59722652
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57009083
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56842339
72beta-Alanine metabolism_Homo sapiens_hsa004100.56528761
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56523538
74Circadian rhythm_Homo sapiens_hsa047100.54131504
75Alzheimers disease_Homo sapiens_hsa050100.52889273
76Autoimmune thyroid disease_Homo sapiens_hsa053200.52629955
77Type I diabetes mellitus_Homo sapiens_hsa049400.52480628
78ABC transporters_Homo sapiens_hsa020100.52125647
79Calcium signaling pathway_Homo sapiens_hsa040200.51295884
80Long-term depression_Homo sapiens_hsa047300.50789987
81Oocyte meiosis_Homo sapiens_hsa041140.50084842
82Metabolic pathways_Homo sapiens_hsa011000.49850978
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48348485
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46994189
85Fatty acid metabolism_Homo sapiens_hsa012120.46882826
86Fat digestion and absorption_Homo sapiens_hsa049750.46191309
87RNA transport_Homo sapiens_hsa030130.46035370
88Cocaine addiction_Homo sapiens_hsa050300.45089964
89Proteasome_Homo sapiens_hsa030500.44583422
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42977327
91Lysine degradation_Homo sapiens_hsa003100.42724434
92Cholinergic synapse_Homo sapiens_hsa047250.42664703
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.38837006
94Fatty acid elongation_Homo sapiens_hsa000620.37883843
95Renin secretion_Homo sapiens_hsa049240.37464655
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36607656
97Allograft rejection_Homo sapiens_hsa053300.35227474
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34861286
99Gastric acid secretion_Homo sapiens_hsa049710.34354365
100Pyrimidine metabolism_Homo sapiens_hsa002400.33390725

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