ZNF559-ZNF177

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 559 (ZNF559) and zinc finger protein 177 (ZNF177) genes on chromosome 19. Alternative splicing results in multiple transcript variants, which encode the ZNF177 protein due to either leaky scanning by ribosomes, or absence of the ZNF559 start codon. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.16537256
2pyrimidine nucleobase catabolic process (GO:0006208)4.75130462
3presynaptic membrane organization (GO:0097090)4.59350801
4postsynaptic membrane organization (GO:0001941)4.30748421
5positive regulation of mitochondrial fission (GO:0090141)4.23354281
6neuron cell-cell adhesion (GO:0007158)4.05797920
7nucleobase catabolic process (GO:0046113)3.99960136
8response to pheromone (GO:0019236)3.91928104
9vocalization behavior (GO:0071625)3.68882930
10protein localization to synapse (GO:0035418)3.63844202
11intraciliary transport (GO:0042073)3.62873077
12nonmotile primary cilium assembly (GO:0035058)3.49489573
13regulation of cilium movement (GO:0003352)3.44253054
14C4-dicarboxylate transport (GO:0015740)3.40779019
15epithelial cilium movement (GO:0003351)3.36069414
16neural tube formation (GO:0001841)3.29512370
17neurotransmitter-gated ion channel clustering (GO:0072578)3.26937388
18protein polyglutamylation (GO:0018095)3.21345483
19DNA double-strand break processing (GO:0000729)3.11235308
20protein localization to cilium (GO:0061512)3.09142598
21cilium morphogenesis (GO:0060271)3.08936641
22olfactory bulb development (GO:0021772)3.07120303
23behavioral response to nicotine (GO:0035095)3.06425321
24retinal cone cell development (GO:0046549)3.03915016
25mechanosensory behavior (GO:0007638)2.98275265
26gamma-aminobutyric acid transport (GO:0015812)2.97853055
27auditory behavior (GO:0031223)2.97385413
28microtubule depolymerization (GO:0007019)2.95751861
29seminiferous tubule development (GO:0072520)2.90794190
30limb bud formation (GO:0060174)2.87575226
31cilium assembly (GO:0042384)2.86984836
32cilium organization (GO:0044782)2.86903189
33calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.84194285
34protein complex biogenesis (GO:0070271)2.79963946
35DNA integration (GO:0015074)2.76209869
36regulation of mitochondrial fission (GO:0090140)2.76083106
37transmission of nerve impulse (GO:0019226)2.75819957
38cilium movement (GO:0003341)2.74201301
39acrosome reaction (GO:0007340)2.72957691
40sequestering of actin monomers (GO:0042989)2.72444324
41epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71993099
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.68203840
43mitochondrial respiratory chain complex assembly (GO:0033108)2.67793893
44mitochondrial respiratory chain complex I assembly (GO:0032981)2.65832874
45NADH dehydrogenase complex assembly (GO:0010257)2.65832874
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65832874
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65711580
48histone H2A acetylation (GO:0043968)2.64641796
49negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.63617102
50negative regulation of translation, ncRNA-mediated (GO:0040033)2.63617102
51regulation of translation, ncRNA-mediated (GO:0045974)2.63617102
52axonal fasciculation (GO:0007413)2.62340842
53regulation of development, heterochronic (GO:0040034)2.62107366
54centriole replication (GO:0007099)2.61928155
55spermatid nucleus differentiation (GO:0007289)2.61161341
56DNA damage response, detection of DNA damage (GO:0042769)2.60282624
57retinal ganglion cell axon guidance (GO:0031290)2.60058881
58synapsis (GO:0007129)2.59174441
59regulation of collateral sprouting (GO:0048670)2.55435180
60axoneme assembly (GO:0035082)2.54561647
61photoreceptor cell maintenance (GO:0045494)2.54029999
62cilium or flagellum-dependent cell motility (GO:0001539)2.53757752
63organelle disassembly (GO:1903008)2.53475161
64regulation of timing of cell differentiation (GO:0048505)2.53372638
65sympathetic nervous system development (GO:0048485)2.51813101
66synapse assembly (GO:0007416)2.50315918
67sperm motility (GO:0030317)2.49265925
68spinal cord motor neuron differentiation (GO:0021522)2.48854801
69anterograde synaptic vesicle transport (GO:0048490)2.48725206
70positive regulation of synapse assembly (GO:0051965)2.46500165
71inner ear receptor stereocilium organization (GO:0060122)2.46195667
72protein-cofactor linkage (GO:0018065)2.46121899
73negative regulation of transcription regulatory region DNA binding (GO:2000678)2.45999242
74piRNA metabolic process (GO:0034587)2.43419929
75neuron recognition (GO:0008038)2.42350972
76neuronal action potential propagation (GO:0019227)2.42325943
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.42259487
78microtubule polymerization or depolymerization (GO:0031109)2.40808719
79head development (GO:0060322)2.40238009
80positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.39806126
81appendage development (GO:0048736)2.37237647
82limb development (GO:0060173)2.37237647
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.33770193
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.33098756
85establishment of protein localization to mitochondrial membrane (GO:0090151)2.32536844
86spinal cord development (GO:0021510)2.32194268
87reciprocal meiotic recombination (GO:0007131)2.30913501
88reciprocal DNA recombination (GO:0035825)2.30913501
89mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.30595128
90positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.30595128
91glycosphingolipid biosynthetic process (GO:0006688)2.30085946
92photoreceptor cell development (GO:0042461)2.30020483
93cullin deneddylation (GO:0010388)2.29163663
94neuronal action potential (GO:0019228)2.28872020
95regulation of microtubule-based movement (GO:0060632)2.27916852
96regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.26639101
97fatty acid elongation (GO:0030497)2.26430695
98behavioral response to ethanol (GO:0048149)2.26181407
99spermatid development (GO:0007286)2.24649646
100righting reflex (GO:0060013)2.23096869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.60488214
2GBX2_23144817_ChIP-Seq_PC3_Human3.28135098
3IGF1R_20145208_ChIP-Seq_DFB_Human3.09290199
4EZH2_22144423_ChIP-Seq_EOC_Human3.05577243
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78862749
6VDR_22108803_ChIP-Seq_LS180_Human2.78655126
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.70381489
8FUS_26573619_Chip-Seq_HEK293_Human2.68341556
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64667303
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.56538110
11TAF15_26573619_Chip-Seq_HEK293_Human2.53054594
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45355790
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41479039
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.38426550
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19288076
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18933695
17EWS_26573619_Chip-Seq_HEK293_Human2.15894242
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14107728
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13231320
20P300_19829295_ChIP-Seq_ESCs_Human2.13032716
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06498918
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98025321
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87801784
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77419434
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.76060967
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74634298
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71240314
28ER_23166858_ChIP-Seq_MCF-7_Human1.71074457
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.67704650
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66974216
31SMAD4_21799915_ChIP-Seq_A2780_Human1.64971161
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.64266588
33CBP_20019798_ChIP-Seq_JUKART_Human1.63458589
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63458589
35ELK1_19687146_ChIP-ChIP_HELA_Human1.62676796
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62645842
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.58328192
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57123584
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56861212
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54900283
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54017403
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.52886211
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51334945
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.49808200
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48003731
46STAT3_23295773_ChIP-Seq_U87_Human1.46583469
47AR_25329375_ChIP-Seq_VCAP_Human1.45467747
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44982908
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42861210
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40462133
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.40255030
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39449405
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39449405
54RNF2_27304074_Chip-Seq_NSC_Mouse1.38866128
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36322381
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34733189
57TCF4_23295773_ChIP-Seq_U87_Human1.33773534
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32223319
59REST_21632747_ChIP-Seq_MESCs_Mouse1.22915349
60BCAT_22108803_ChIP-Seq_LS180_Human1.22333898
61MYC_18940864_ChIP-ChIP_HL60_Human1.20097705
62TP53_22573176_ChIP-Seq_HFKS_Human1.17847729
63RUNX2_22187159_ChIP-Seq_PCA_Human1.17565562
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17298913
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16645110
66IRF1_19129219_ChIP-ChIP_H3396_Human1.16044381
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15525825
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.15181413
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15023147
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13792920
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12142281
72VDR_23849224_ChIP-Seq_CD4+_Human1.11659475
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.11594411
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10981263
75TCF4_22108803_ChIP-Seq_LS180_Human1.10677312
76AR_21572438_ChIP-Seq_LNCaP_Human1.09625144
77SOX2_19829295_ChIP-Seq_ESCs_Human1.09250866
78NANOG_19829295_ChIP-Seq_ESCs_Human1.09250866
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08948023
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06857594
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06843345
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.06127716
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04897919
84JUN_21703547_ChIP-Seq_K562_Human1.02721567
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.01749583
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.01252302
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.00785794
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00620234
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00234312
90SOX2_16153702_ChIP-ChIP_HESCs_Human0.99039170
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97977073
92ETS1_20019798_ChIP-Seq_JURKAT_Human0.96797994
93TAL1_26923725_Chip-Seq_HPCs_Mouse0.96280063
94SOX9_26525672_Chip-Seq_HEART_Mouse0.96194186
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96150133
96P53_22387025_ChIP-Seq_ESCs_Mouse0.95892753
97FLI1_21867929_ChIP-Seq_TH2_Mouse0.95751722
98REST_18959480_ChIP-ChIP_MESCs_Mouse0.95583009
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93785407
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92394495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern2.76158025
2MP0008877_abnormal_DNA_methylation2.75094986
3MP0002102_abnormal_ear_morphology2.72059122
4MP0001529_abnormal_vocalization2.59693278
5MP0001984_abnormal_olfaction2.59581058
6MP0002736_abnormal_nociception_after2.44653552
7MP0001968_abnormal_touch/_nociception2.29047879
8MP0003136_yellow_coat_color2.17558868
9MP0003122_maternal_imprinting1.99686717
10MP0003787_abnormal_imprinting1.94209524
11MP0006072_abnormal_retinal_apoptosis1.93591450
12MP0006292_abnormal_olfactory_placode1.92126636
13MP0002751_abnormal_autonomic_nervous1.91951866
14MP0002735_abnormal_chemical_nociception1.91567984
15MP0005551_abnormal_eye_electrophysiolog1.88985362
16MP0000372_irregular_coat_pigmentation1.88801005
17MP0003121_genomic_imprinting1.87146683
18MP0005253_abnormal_eye_physiology1.84283267
19MP0000778_abnormal_nervous_system1.83131991
20MP0006276_abnormal_autonomic_nervous1.82780342
21MP0002234_abnormal_pharynx_morphology1.80737014
22MP0001486_abnormal_startle_reflex1.80134262
23MP0008789_abnormal_olfactory_epithelium1.78034730
24MP0005499_abnormal_olfactory_system1.74997086
25MP0005394_taste/olfaction_phenotype1.74997086
26MP0000569_abnormal_digit_pigmentation1.69501846
27MP0002938_white_spotting1.69357492
28MP0002272_abnormal_nervous_system1.67511648
29MP0009046_muscle_twitch1.63521840
30MP0005645_abnormal_hypothalamus_physiol1.61768256
31MP0009745_abnormal_behavioral_response1.50714663
32MP0004270_analgesia1.50356467
33MP0008058_abnormal_DNA_repair1.49741359
34MP0003718_maternal_effect1.47647532
35MP0004859_abnormal_synaptic_plasticity1.47626752
36MP0001986_abnormal_taste_sensitivity1.46362339
37MP0003635_abnormal_synaptic_transmissio1.44346939
38MP0005187_abnormal_penis_morphology1.43672937
39MP0002837_dystrophic_cardiac_calcinosis1.42463065
40MP0002653_abnormal_ependyma_morphology1.41544975
41MP0001293_anophthalmia1.37632883
42MP0000631_abnormal_neuroendocrine_gland1.35867195
43MP0002734_abnormal_mechanical_nocicepti1.33646390
44MP0000049_abnormal_middle_ear1.31636623
45MP0005423_abnormal_somatic_nervous1.30424785
46MP0002572_abnormal_emotion/affect_behav1.30306693
47MP0003890_abnormal_embryonic-extraembry1.29374507
48MP0005410_abnormal_fertilization1.29034071
49MP0002557_abnormal_social/conspecific_i1.28344515
50MP0001485_abnormal_pinna_reflex1.27876150
51MP0002064_seizures1.26963076
52MP0004142_abnormal_muscle_tone1.23066058
53MP0003698_abnormal_male_reproductive1.23048942
54MP0002067_abnormal_sensory_capabilities1.21010886
55MP0005171_absent_coat_pigmentation1.20355117
56MP0002063_abnormal_learning/memory/cond1.19920188
57MP0008995_early_reproductive_senescence1.18031129
58MP0002184_abnormal_innervation1.17291104
59MP0004133_heterotaxia1.16374458
60MP0002233_abnormal_nose_morphology1.15383167
61MP0000566_synostosis1.11857487
62MP0001929_abnormal_gametogenesis1.11498429
63MP0003119_abnormal_digestive_system1.11141782
64MP0003195_calcinosis1.10787611
65MP0000955_abnormal_spinal_cord1.10122894
66MP0000647_abnormal_sebaceous_gland1.08106964
67MP0002822_catalepsy1.07696870
68MP0001970_abnormal_pain_threshold1.07684995
69MP0003567_abnormal_fetal_cardiomyocyte1.07237355
70MP0004924_abnormal_behavior1.05391667
71MP0005386_behavior/neurological_phenoty1.05391667
72MP0002638_abnormal_pupillary_reflex1.04297421
73MP0002752_abnormal_somatic_nervous1.04003693
74MP0002882_abnormal_neuron_morphology1.03785278
75MP0002909_abnormal_adrenal_gland1.01497309
76MP0005391_vision/eye_phenotype1.01314407
77MP0001299_abnormal_eye_distance/0.98021130
78MP0003011_delayed_dark_adaptation0.98007722
79MP0002210_abnormal_sex_determination0.97700473
80MP0002733_abnormal_thermal_nociception0.96119865
81MP0001188_hyperpigmentation0.93967436
82MP0004811_abnormal_neuron_physiology0.93268108
83MP0000427_abnormal_hair_cycle0.93209324
84MP0009697_abnormal_copulation0.93191155
85MP0010094_abnormal_chromosome_stability0.90698409
86MP0003937_abnormal_limbs/digits/tail_de0.90381821
87MP0005195_abnormal_posterior_eye0.90155431
88MP0005084_abnormal_gallbladder_morpholo0.89669197
89MP0003861_abnormal_nervous_system0.88281504
90MP0000026_abnormal_inner_ear0.87317469
91MP0002152_abnormal_brain_morphology0.86004166
92MP0003755_abnormal_palate_morphology0.83949214
93MP0004215_abnormal_myocardial_fiber0.83739785
94MP0006035_abnormal_mitochondrial_morpho0.83028994
95MP0000653_abnormal_sex_gland0.82319353
96MP0001963_abnormal_hearing_physiology0.81574492
97MP0001905_abnormal_dopamine_level0.79309240
98MP0002095_abnormal_skin_pigmentation0.78337678
99MP0004145_abnormal_muscle_electrophysio0.78275183
100MP0004885_abnormal_endolymph0.76477504

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.68138973
2Pancreatic fibrosis (HP:0100732)3.63497339
3Pancreatic cysts (HP:0001737)3.48904806
4Medial flaring of the eyebrow (HP:0010747)3.48194081
5Gait imbalance (HP:0002141)3.42424870
6True hermaphroditism (HP:0010459)3.34714448
7Congenital primary aphakia (HP:0007707)3.30048442
8Chronic hepatic failure (HP:0100626)3.10967252
9Genital tract atresia (HP:0001827)3.05961950
10Abnormality of the labia minora (HP:0012880)3.00608948
11Drooling (HP:0002307)2.96495778
12Vaginal atresia (HP:0000148)2.94313380
13Nephrogenic diabetes insipidus (HP:0009806)2.92803137
14Molar tooth sign on MRI (HP:0002419)2.91799188
15Abnormality of midbrain morphology (HP:0002418)2.91799188
16Nephronophthisis (HP:0000090)2.84093523
17Focal motor seizures (HP:0011153)2.79296660
18Tubulointerstitial nephritis (HP:0001970)2.66384841
19Excessive salivation (HP:0003781)2.66168599
20Broad-based gait (HP:0002136)2.52530647
21Absent speech (HP:0001344)2.51796781
22Poor coordination (HP:0002370)2.43973179
23Hyperglycinemia (HP:0002154)2.43881344
24Hemiparesis (HP:0001269)2.41109401
25Abnormality of the renal medulla (HP:0100957)2.40602034
26Retinal dysplasia (HP:0007973)2.39874215
27Methylmalonic acidemia (HP:0002912)2.39054260
28Intestinal atresia (HP:0011100)2.38871510
29Methylmalonic aciduria (HP:0012120)2.38017225
30Polyphagia (HP:0002591)2.37710684
31Postaxial hand polydactyly (HP:0001162)2.27316751
32Lissencephaly (HP:0001339)2.26631230
33Focal seizures (HP:0007359)2.26558234
34Optic nerve hypoplasia (HP:0000609)2.21511796
35Type II lissencephaly (HP:0007260)2.20192781
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.19360688
37Acute necrotizing encephalopathy (HP:0006965)2.18865942
38Cystic liver disease (HP:0006706)2.18513736
39Inability to walk (HP:0002540)2.17180699
40Broad foot (HP:0001769)2.16485241
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.16184570
42Pendular nystagmus (HP:0012043)2.15725706
43Postaxial foot polydactyly (HP:0001830)2.11883791
44Gonadotropin excess (HP:0000837)2.09384087
45Mitochondrial inheritance (HP:0001427)2.08948707
46Increased CSF lactate (HP:0002490)2.08777366
47Gaze-evoked nystagmus (HP:0000640)2.08159128
48Atonic seizures (HP:0010819)2.07237694
49Anencephaly (HP:0002323)2.06061664
50Progressive inability to walk (HP:0002505)2.04915027
51Sclerocornea (HP:0000647)2.03014183
52Specific learning disability (HP:0001328)2.02369620
53Bifid tongue (HP:0010297)2.01512669
54Septo-optic dysplasia (HP:0100842)2.01366361
55Preaxial hand polydactyly (HP:0001177)2.00264503
56Acute encephalopathy (HP:0006846)1.99370573
57Febrile seizures (HP:0002373)1.99270420
58Pachygyria (HP:0001302)1.98676098
59Abnormal mitochondria in muscle tissue (HP:0008316)1.96897352
60Hyperglycinuria (HP:0003108)1.96529555
61Narrow forehead (HP:0000341)1.95405609
62Abnormality of the renal cortex (HP:0011035)1.94942643
63Congenital hepatic fibrosis (HP:0002612)1.94375611
64Volvulus (HP:0002580)1.92415208
65Short tibia (HP:0005736)1.92332864
66Decreased testicular size (HP:0008734)1.91932043
67Progressive macrocephaly (HP:0004481)1.91511681
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90714255
69Renal hypoplasia (HP:0000089)1.90065150
70Colon cancer (HP:0003003)1.87945193
71Increased hepatocellular lipid droplets (HP:0006565)1.87248255
72Occipital encephalocele (HP:0002085)1.87184032
73Abolished electroretinogram (ERG) (HP:0000550)1.86799985
74Astigmatism (HP:0000483)1.84711135
75Progressive cerebellar ataxia (HP:0002073)1.84518631
76Abnormal biliary tract physiology (HP:0012439)1.84418246
77Bile duct proliferation (HP:0001408)1.84418246
78Aplasia/Hypoplasia of the lens (HP:0008063)1.84007032
79Limb dystonia (HP:0002451)1.83948564
80Abnormal respiratory motile cilium morphology (HP:0005938)1.83739322
81Abnormal respiratory epithelium morphology (HP:0012253)1.83739322
82Abnormality of serine family amino acid metabolism (HP:0010894)1.81961533
83Abnormality of glycine metabolism (HP:0010895)1.81961533
84Hepatocellular necrosis (HP:0001404)1.81089775
85Dialeptic seizures (HP:0011146)1.80702489
86Cortical dysplasia (HP:0002539)1.79842136
87Hepatic necrosis (HP:0002605)1.79519266
88Amyotrophic lateral sclerosis (HP:0007354)1.78984172
89Congenital stationary night blindness (HP:0007642)1.78411260
90Micropenis (HP:0000054)1.78400116
91Epileptic encephalopathy (HP:0200134)1.76516220
92Cerebellar dysplasia (HP:0007033)1.74746208
93Aganglionic megacolon (HP:0002251)1.74603603
94Lipid accumulation in hepatocytes (HP:0006561)1.74096542
95Failure to thrive in infancy (HP:0001531)1.70071629
96Gastrointestinal atresia (HP:0002589)1.69114652
97Renal cortical cysts (HP:0000803)1.68522650
98Renal Fanconi syndrome (HP:0001994)1.68486443
99Anophthalmia (HP:0000528)1.67491281
100Short foot (HP:0001773)1.66567813

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K43.55486365
2CASK3.54656598
3WNK33.14361259
4MARK12.94157933
5FRK2.90883872
6MAP2K72.48292274
7TRIM282.45663397
8MAPK132.35079209
9MAP4K22.34733413
10BCR2.27300487
11PINK12.03025385
12PLK22.00069862
13SRPK11.77109535
14EPHA31.75433015
15NUAK11.74632082
16DYRK21.70219582
17ZAK1.69845452
18INSRR1.68563132
19BMPR1B1.68289888
20PAK31.59613013
21MKNK11.57614460
22EPHA41.50094501
23TNIK1.46057218
24CSNK1G21.42171715
25ERBB31.41454702
26PLK41.39622499
27CSNK1G31.39534747
28MKNK21.38868717
29CSNK1G11.34816008
30BRD41.26772655
31PLK31.23283381
32CSNK1A1L1.22492392
33VRK11.22229389
34STK38L1.14341831
35BCKDK1.11100385
36EIF2AK31.10852036
37OXSR11.10469838
38CAMKK21.06242278
39PRKCE1.05204722
40BUB10.99182396
41NTRK20.97290833
42PDK20.96491670
43DYRK30.95575950
44STK390.93129023
45MAP2K40.90526574
46ADRBK20.90019631
47VRK20.88957426
48GRK10.88721025
49BRSK20.88554024
50PRKCG0.85294771
51UHMK10.84008166
52PNCK0.83542886
53PKN10.78719459
54CDK190.78500113
55AKT30.77057817
56WEE10.76554263
57STK160.70143928
58FER0.67461222
59CCNB10.66570631
60RPS6KA40.64638907
61MINK10.61126055
62CAMK2A0.60824219
63WNK40.60298713
64ERBB40.59438797
65DYRK1A0.58873766
66CDK30.58344711
67FGFR20.58316579
68PLK10.56430762
69NTRK30.52350646
70ACVR1B0.48973463
71CDC70.47945566
72GRK70.47654968
73PRKACB0.47283357
74NEK10.46819170
75PHKG20.46644341
76PHKG10.46644341
77CSNK1D0.42666905
78CDK50.42629497
79ATR0.42057175
80ATM0.41828262
81RPS6KA50.41680573
82OBSCN0.41404800
83CSNK1A10.41361760
84TTK0.40663068
85PRKACA0.39969586
86MST40.38183466
87ADRBK10.38157072
88MAPKAPK50.37948425
89DAPK20.37502278
90TSSK60.36784595
91PTK2B0.35129018
92CAMK2B0.33121456
93MUSK0.32168463
94TGFBR10.31807608
95TIE10.31798566
96SGK20.30782454
97FGFR10.30032134
98SGK4940.29277721
99SGK2230.29277721
100GRK50.28757194

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.03598546
2Propanoate metabolism_Homo sapiens_hsa006402.78304494
3Protein export_Homo sapiens_hsa030602.74156325
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.47181078
5Nicotine addiction_Homo sapiens_hsa050332.45973580
6Oxidative phosphorylation_Homo sapiens_hsa001902.37309360
7Butanoate metabolism_Homo sapiens_hsa006502.33649633
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27478814
9Basal transcription factors_Homo sapiens_hsa030222.15918388
10RNA polymerase_Homo sapiens_hsa030202.15705708
11Parkinsons disease_Homo sapiens_hsa050122.10850850
12Non-homologous end-joining_Homo sapiens_hsa034502.03010815
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01586598
14Fanconi anemia pathway_Homo sapiens_hsa034601.87788078
15Steroid biosynthesis_Homo sapiens_hsa001001.87679277
16Homologous recombination_Homo sapiens_hsa034401.84369048
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84075300
18Phototransduction_Homo sapiens_hsa047441.79614789
19RNA degradation_Homo sapiens_hsa030181.68358183
20Huntingtons disease_Homo sapiens_hsa050161.66373974
21Taste transduction_Homo sapiens_hsa047421.64056801
22Proteasome_Homo sapiens_hsa030501.50398080
23Fatty acid elongation_Homo sapiens_hsa000621.39341942
24GABAergic synapse_Homo sapiens_hsa047271.35768140
25Selenocompound metabolism_Homo sapiens_hsa004501.35730439
26Mismatch repair_Homo sapiens_hsa034301.35012676
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34445573
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33742794
29Alzheimers disease_Homo sapiens_hsa050101.26861145
30Olfactory transduction_Homo sapiens_hsa047401.25336284
31Regulation of autophagy_Homo sapiens_hsa041401.24478735
32RNA transport_Homo sapiens_hsa030131.21743408
33Cardiac muscle contraction_Homo sapiens_hsa042601.20895539
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20013541
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19523622
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18679299
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16538998
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.14933623
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14773752
40Nucleotide excision repair_Homo sapiens_hsa034201.13517380
41Glutamatergic synapse_Homo sapiens_hsa047241.06381922
42beta-Alanine metabolism_Homo sapiens_hsa004101.05050411
43Base excision repair_Homo sapiens_hsa034101.01713729
44Collecting duct acid secretion_Homo sapiens_hsa049661.01025131
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00906105
46Fatty acid metabolism_Homo sapiens_hsa012120.97991906
47Morphine addiction_Homo sapiens_hsa050320.96685597
48Circadian entrainment_Homo sapiens_hsa047130.96169656
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.96108943
50Ether lipid metabolism_Homo sapiens_hsa005650.95733475
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95434719
52Peroxisome_Homo sapiens_hsa041460.93382368
53Purine metabolism_Homo sapiens_hsa002300.91406416
54Circadian rhythm_Homo sapiens_hsa047100.90843063
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89486565
56Oocyte meiosis_Homo sapiens_hsa041140.87855916
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87397414
58Dopaminergic synapse_Homo sapiens_hsa047280.87309292
59Linoleic acid metabolism_Homo sapiens_hsa005910.85701255
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.79156167
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77917883
62Spliceosome_Homo sapiens_hsa030400.75825761
63mRNA surveillance pathway_Homo sapiens_hsa030150.75273918
64Tryptophan metabolism_Homo sapiens_hsa003800.75073686
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74183771
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74011665
67One carbon pool by folate_Homo sapiens_hsa006700.73208080
68Synaptic vesicle cycle_Homo sapiens_hsa047210.71660614
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71137042
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69140487
71Nitrogen metabolism_Homo sapiens_hsa009100.68629657
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68249730
73Amphetamine addiction_Homo sapiens_hsa050310.67283119
74Metabolic pathways_Homo sapiens_hsa011000.66914824
75Cocaine addiction_Homo sapiens_hsa050300.62364451
76Serotonergic synapse_Homo sapiens_hsa047260.61588823
77Hedgehog signaling pathway_Homo sapiens_hsa043400.59678193
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58727081
79Pyrimidine metabolism_Homo sapiens_hsa002400.58428201
80Insulin secretion_Homo sapiens_hsa049110.57339769
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53082674
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50327163
83Axon guidance_Homo sapiens_hsa043600.49980046
84ABC transporters_Homo sapiens_hsa020100.49452481
85Chemical carcinogenesis_Homo sapiens_hsa052040.48814578
86Pyruvate metabolism_Homo sapiens_hsa006200.48024553
87Caffeine metabolism_Homo sapiens_hsa002320.47834005
88Lysine degradation_Homo sapiens_hsa003100.46726870
89Retinol metabolism_Homo sapiens_hsa008300.45938823
90Fatty acid degradation_Homo sapiens_hsa000710.45769309
91Carbon metabolism_Homo sapiens_hsa012000.44494220
92Cell cycle_Homo sapiens_hsa041100.43927423
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43255137
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43212591
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.42340670
96Long-term depression_Homo sapiens_hsa047300.42012767
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41648652
98Calcium signaling pathway_Homo sapiens_hsa040200.41100370
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40967517
100Glutathione metabolism_Homo sapiens_hsa004800.38856272

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