ZNF560

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.84213852
2synapsis (GO:0007129)5.48987552
3regulation of retinoic acid receptor signaling pathway (GO:0048385)5.22079381
4protein localization to kinetochore (GO:0034501)4.90508322
5CENP-A containing nucleosome assembly (GO:0034080)4.57588681
6mitotic metaphase plate congression (GO:0007080)4.56569364
7chromatin remodeling at centromere (GO:0031055)4.43924980
8piRNA metabolic process (GO:0034587)4.31038265
9histone exchange (GO:0043486)4.29411071
10DNA damage response, detection of DNA damage (GO:0042769)4.18920404
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.10914284
12regulation of DNA methylation (GO:0044030)4.08439387
13resolution of meiotic recombination intermediates (GO:0000712)4.08409184
14metaphase plate congression (GO:0051310)4.01773298
15protein localization to chromosome, centromeric region (GO:0071459)4.01299531
16regulation of gene silencing by RNA (GO:0060966)3.93813938
17regulation of posttranscriptional gene silencing (GO:0060147)3.93813938
18regulation of gene silencing by miRNA (GO:0060964)3.93813938
19mitotic sister chromatid cohesion (GO:0007064)3.92858724
20DNA replication-independent nucleosome organization (GO:0034724)3.88619640
21DNA replication-independent nucleosome assembly (GO:0006336)3.88619640
22attachment of spindle microtubules to kinetochore (GO:0008608)3.78610976
23DNA replication-dependent nucleosome organization (GO:0034723)3.73304430
24DNA replication-dependent nucleosome assembly (GO:0006335)3.73304430
25regulation of meiosis I (GO:0060631)3.63087269
26protein K11-linked deubiquitination (GO:0035871)3.58826256
27nuclear pore organization (GO:0006999)3.53726935
28regulation of spindle organization (GO:0090224)3.48722753
29chromosome organization involved in meiosis (GO:0070192)3.44920698
30presynaptic membrane assembly (GO:0097105)3.41984382
31acrosome assembly (GO:0001675)3.41548848
32otic vesicle formation (GO:0030916)3.36648367
33spindle checkpoint (GO:0031577)3.32030807
34lymphangiogenesis (GO:0001946)3.31414597
35male meiosis (GO:0007140)3.28429506
36paraxial mesoderm development (GO:0048339)3.23596947
37mechanosensory behavior (GO:0007638)3.18307547
38meiotic cell cycle (GO:0051321)3.15430618
39mitotic spindle checkpoint (GO:0071174)3.12781714
40male meiosis I (GO:0007141)3.09475699
41nodal signaling pathway (GO:0038092)3.09140475
42DNA replication checkpoint (GO:0000076)3.09052941
43negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.08097351
44negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.08097351
45negative regulation of mitotic sister chromatid segregation (GO:0033048)3.08097351
46negative regulation of mitotic sister chromatid separation (GO:2000816)3.08097351
47negative regulation of sister chromatid segregation (GO:0033046)3.08097351
48establishment of chromosome localization (GO:0051303)3.06990038
49negative regulation of chromosome segregation (GO:0051985)3.06416860
50replication fork processing (GO:0031297)3.06163222
51retinal cone cell development (GO:0046549)3.05908632
52mitotic sister chromatid segregation (GO:0000070)3.04698262
53regulation of acrosome reaction (GO:0060046)3.04112203
54transcription elongation from RNA polymerase III promoter (GO:0006385)3.01109931
55termination of RNA polymerase III transcription (GO:0006386)3.01109931
56sister chromatid segregation (GO:0000819)3.00495546
57regulation of histone H3-K9 methylation (GO:0051570)3.00378145
58regulation of DNA endoreduplication (GO:0032875)2.99448490
59sister chromatid cohesion (GO:0007062)2.98623703
60spermatid nucleus differentiation (GO:0007289)2.97277057
61DNA methylation involved in gamete generation (GO:0043046)2.97086251
62histone H2A acetylation (GO:0043968)2.96653613
63regulation of chromosome segregation (GO:0051983)2.96606407
64DNA double-strand break processing (GO:0000729)2.96470717
65single strand break repair (GO:0000012)2.93532377
66negative regulation of DNA-dependent DNA replication (GO:2000104)2.93508632
67meiotic cell cycle process (GO:1903046)2.92697610
68protein localization to chromosome (GO:0034502)2.92670553
69cardiac right ventricle morphogenesis (GO:0003215)2.89074261
70regulation of centriole replication (GO:0046599)2.86940447
71gene silencing by RNA (GO:0031047)2.85146489
72mitotic spindle assembly checkpoint (GO:0007094)2.83855811
73ribosome assembly (GO:0042255)2.83410413
74regulation of sister chromatid segregation (GO:0033045)2.81995197
75regulation of mitotic sister chromatid separation (GO:0010965)2.81995197
76regulation of mitotic sister chromatid segregation (GO:0033047)2.81995197
77establishment of integrated proviral latency (GO:0075713)2.79410252
78positive regulation of chromosome segregation (GO:0051984)2.78537829
79DNA ligation (GO:0006266)2.77091597
80spindle assembly checkpoint (GO:0071173)2.76437965
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.76226395
82regulation of mitotic metaphase/anaphase transition (GO:0030071)2.76226395
83nuclear pore complex assembly (GO:0051292)2.75243808
84ATP-dependent chromatin remodeling (GO:0043044)2.72674773
85negative regulation of gene silencing (GO:0060969)2.72239917
86presynaptic membrane organization (GO:0097090)2.72007930
87centriole replication (GO:0007099)2.70484200
88regulation of chromatin silencing (GO:0031935)2.70114188
89mitotic chromosome condensation (GO:0007076)2.69967972
90regulation of centrosome cycle (GO:0046605)2.68467066
91regulation of mitotic spindle checkpoint (GO:1903504)2.66353393
92regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.66353393
93regulation of gene silencing (GO:0060968)2.65560084
94anterior/posterior axis specification, embryo (GO:0008595)2.65486135
95histone mRNA metabolic process (GO:0008334)2.64527809
96chromatin assembly or disassembly (GO:0006333)2.64314926
97spindle assembly involved in mitosis (GO:0090307)2.64241440
98meiosis I (GO:0007127)2.63699564
99protein K6-linked ubiquitination (GO:0085020)2.63493582
100regulation of translation, ncRNA-mediated (GO:0045974)2.63210719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.79283170
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.02951085
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.52424137
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.29163237
5ZNF274_21170338_ChIP-Seq_K562_Hela2.81806911
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.80322861
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60691398
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.58654123
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56064935
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.54322631
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.51421940
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.51421940
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.51421940
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37657941
15ELK1_19687146_ChIP-ChIP_HELA_Human2.33273293
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.30485937
17GBX2_23144817_ChIP-Seq_PC3_Human2.27874012
18EWS_26573619_Chip-Seq_HEK293_Human2.23932612
19FUS_26573619_Chip-Seq_HEK293_Human2.18628774
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12380839
21* TP63_19390658_ChIP-ChIP_HaCaT_Human2.09793050
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04577267
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99100359
24VDR_22108803_ChIP-Seq_LS180_Human1.93986364
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.92384606
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.89713739
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.88542450
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81120093
29MYC_18940864_ChIP-ChIP_HL60_Human1.80293377
30EZH2_22144423_ChIP-Seq_EOC_Human1.78433054
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76542316
32P300_19829295_ChIP-Seq_ESCs_Human1.71380198
33AR_21909140_ChIP-Seq_LNCAP_Human1.70921465
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68373689
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63545162
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63509239
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63265456
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60610712
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52678594
40TAF15_26573619_Chip-Seq_HEK293_Human1.50934574
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44006469
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41737196
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39781553
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37476574
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35674620
46BCAT_22108803_ChIP-Seq_LS180_Human1.35626698
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33021985
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30850706
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30744099
50TTF2_22483619_ChIP-Seq_HELA_Human1.29525378
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.27000951
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.26405782
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24180379
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23806294
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.22322832
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.18569835
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.18498337
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18371698
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18371698
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16725996
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16350689
62VDR_23849224_ChIP-Seq_CD4+_Human1.15937823
63AR_21572438_ChIP-Seq_LNCaP_Human1.15459404
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13757954
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.13662730
66TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11510472
67STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10757478
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.10087618
69TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10028254
70SMAD4_21799915_ChIP-Seq_A2780_Human1.09544279
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.09248822
72FOXP3_21729870_ChIP-Seq_TREG_Human1.09181815
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08339370
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08252778
75AR_25329375_ChIP-Seq_VCAP_Human1.05671919
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03467511
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02404414
78TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02351445
79SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02143388
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01573690
81PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97777483
82TP53_22573176_ChIP-Seq_HFKS_Human0.97004250
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96901727
84TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96290433
85GATA1_26923725_Chip-Seq_HPCs_Mouse0.96271463
86ER_23166858_ChIP-Seq_MCF-7_Human0.96011720
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95044223
88IGF1R_20145208_ChIP-Seq_DFB_Human0.94832216
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94301242
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93333644
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93207539
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92740661
93TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91830147
94SMAD3_21741376_ChIP-Seq_EPCs_Human0.91830022
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90741157
96MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90086180
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89762592
98POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88650882
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88106727
100RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87649014

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.12813368
2MP0003718_maternal_effect3.90603129
3MP0008877_abnormal_DNA_methylation3.63808440
4MP0010030_abnormal_orbit_morphology3.25928349
5MP0006292_abnormal_olfactory_placode3.01065082
6MP0003693_abnormal_embryo_hatching2.92731575
7MP0003136_yellow_coat_color2.89617999
8MP0010094_abnormal_chromosome_stability2.87070297
9MP0003941_abnormal_skin_development2.75697559
10MP0008058_abnormal_DNA_repair2.73299161
11MP0004957_abnormal_blastocyst_morpholog2.58846405
12MP0003111_abnormal_nucleus_morphology2.12907703
13MP0003077_abnormal_cell_cycle2.05125793
14MP0009379_abnormal_foot_pigmentation2.03607076
15MP0003890_abnormal_embryonic-extraembry1.96138585
16MP0006072_abnormal_retinal_apoptosis1.78941876
17MP0002210_abnormal_sex_determination1.78480425
18MP0008057_abnormal_DNA_replication1.74321180
19MP0003567_abnormal_fetal_cardiomyocyte1.73851186
20MP0008932_abnormal_embryonic_tissue1.70192107
21MP0001919_abnormal_reproductive_system1.61539293
22MP0001293_anophthalmia1.60716357
23MP0001929_abnormal_gametogenesis1.60663227
24MP0003937_abnormal_limbs/digits/tail_de1.57960996
25MP0005551_abnormal_eye_electrophysiolog1.57025848
26MP0008789_abnormal_olfactory_epithelium1.56681429
27MP0005395_other_phenotype1.52027576
28MP0002233_abnormal_nose_morphology1.49546387
29MP0009250_abnormal_appendicular_skeleto1.47839070
30MP0010307_abnormal_tumor_latency1.47115500
31MP0005389_reproductive_system_phenotype1.39643721
32MP0000653_abnormal_sex_gland1.38499434
33MP0000049_abnormal_middle_ear1.37833576
34MP0001984_abnormal_olfaction1.37461565
35MP0002085_abnormal_embryonic_tissue1.31173076
36MP0010368_abnormal_lymphatic_system1.30673298
37MP0000778_abnormal_nervous_system1.30502786
38MP0001145_abnormal_male_reproductive1.30188126
39MP0003755_abnormal_palate_morphology1.29553577
40MP0002736_abnormal_nociception_after1.28954876
41MP0005499_abnormal_olfactory_system1.25565355
42MP0005394_taste/olfaction_phenotype1.25565355
43MP0002751_abnormal_autonomic_nervous1.25464606
44MP0002697_abnormal_eye_size1.25363684
45MP0003950_abnormal_plasma_membrane1.22607441
46MP0002084_abnormal_developmental_patter1.19862182
47MP0000647_abnormal_sebaceous_gland1.19501982
48MP0003698_abnormal_male_reproductive1.13791480
49MP0004133_heterotaxia1.13340303
50MP0005380_embryogenesis_phenotype1.13033610
51MP0001672_abnormal_embryogenesis/_devel1.13033610
52MP0003861_abnormal_nervous_system1.12432626
53MP0001286_abnormal_eye_development1.12034171
54MP0001730_embryonic_growth_arrest1.11645401
55MP0002163_abnormal_gland_morphology1.11531377
56MP0004272_abnormal_basement_membrane1.10535431
57MP0000579_abnormal_nail_morphology1.08874498
58MP0000631_abnormal_neuroendocrine_gland1.08441438
59MP0002160_abnormal_reproductive_system1.08332422
60MP0002938_white_spotting1.05619085
61MP0001324_abnormal_eye_pigmentation1.04456293
62MP0003699_abnormal_female_reproductive1.03765481
63MP0001119_abnormal_female_reproductive1.03645146
64MP0000383_abnormal_hair_follicle1.01491332
65MP0002161_abnormal_fertility/fecundity1.01286934
66MP0000762_abnormal_tongue_morphology0.99530421
67MP0000427_abnormal_hair_cycle0.98588809
68MP0000566_synostosis0.98280241
69MP0001529_abnormal_vocalization0.98012612
70MP0001697_abnormal_embryo_size0.94896907
71MP0000350_abnormal_cell_proliferation0.94657023
72MP0000428_abnormal_craniofacial_morphol0.92329836
73MP0000467_abnormal_esophagus_morphology0.92204764
74MP0001879_abnormal_lymphatic_vessel0.92066828
75MP0003121_genomic_imprinting0.91969444
76MP0003935_abnormal_craniofacial_develop0.90610619
77MP0001346_abnormal_lacrimal_gland0.89519466
78MP0005195_abnormal_posterior_eye0.88314869
79MP0001986_abnormal_taste_sensitivity0.87578042
80MP0000432_abnormal_head_morphology0.85988922
81MP0002138_abnormal_hepatobiliary_system0.85332950
82MP0001485_abnormal_pinna_reflex0.84703380
83MP0009703_decreased_birth_body0.84382415
84MP0005410_abnormal_fertilization0.83302621
85MP0003984_embryonic_growth_retardation0.83005218
86MP0004197_abnormal_fetal_growth/weight/0.82690206
87MP0003137_abnormal_impulse_conducting0.82249183
88MP0005174_abnormal_tail_pigmentation0.82233773
89MP0003119_abnormal_digestive_system0.81672834
90MP0002088_abnormal_embryonic_growth/wei0.79476350
91MP0002080_prenatal_lethality0.79416776
92MP0005253_abnormal_eye_physiology0.77123039
93MP0002111_abnormal_tail_morphology0.76899090
94MP0005197_abnormal_uvea_morphology0.73417913
95MP0009672_abnormal_birth_weight0.72580944
96MP0005647_abnormal_sex_gland0.72283393
97MP0002090_abnormal_vision0.72181978
98MP0001177_atelectasis0.70444803
99MP0005187_abnormal_penis_morphology0.70400733
100MP0003787_abnormal_imprinting0.70341335

Predicted human phenotypes

RankGene SetZ-score
1Intestinal atresia (HP:0011100)4.30019679
2Septo-optic dysplasia (HP:0100842)3.62903444
3Gonadotropin excess (HP:0000837)3.61375561
4Gastrointestinal atresia (HP:0002589)3.38683155
5Abnormality of the labia minora (HP:0012880)3.27203552
6Chromsome breakage (HP:0040012)3.22917055
7Oligodactyly (hands) (HP:0001180)3.20280437
8Abnormality of the ileum (HP:0001549)3.16309947
9Meckel diverticulum (HP:0002245)3.14320561
10Bifid tongue (HP:0010297)3.10290368
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.09843147
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.07954817
13Pancreatic cysts (HP:0001737)3.01016615
14True hermaphroditism (HP:0010459)2.89795202
15Hypoplasia of the uterus (HP:0000013)2.88272617
16Nephroblastoma (Wilms tumor) (HP:0002667)2.87536510
17Abnormality of chromosome stability (HP:0003220)2.84333984
18Embryonal renal neoplasm (HP:0011794)2.84202271
19Pancreatic fibrosis (HP:0100732)2.81398549
20Volvulus (HP:0002580)2.74287202
21Abnormality of the duodenum (HP:0002246)2.73732767
22Esophageal atresia (HP:0002032)2.72578692
23Absent radius (HP:0003974)2.71359835
24Abnormal lung lobation (HP:0002101)2.69526717
25Absent septum pellucidum (HP:0001331)2.64013245
26Colon cancer (HP:0003003)2.61922611
27Abnormality of the phalanges of the 2nd finger (HP:0009541)2.59995723
28Small intestinal stenosis (HP:0012848)2.58253048
29Duodenal stenosis (HP:0100867)2.58253048
30Triphalangeal thumb (HP:0001199)2.55671882
31Abnormality of the septum pellucidum (HP:0007375)2.53177787
32Aplasia involving forearm bones (HP:0009822)2.51409467
33Absent forearm bone (HP:0003953)2.51409467
34Hypoplastic labia majora (HP:0000059)2.49547748
35Aplasia/Hypoplasia of the tongue (HP:0010295)2.46903454
36Supernumerary spleens (HP:0009799)2.44216208
37Abnormality of the preputium (HP:0100587)2.40194261
38Hyperglycinuria (HP:0003108)2.37671891
39Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.36845388
40Abnormality of the labia majora (HP:0012881)2.32466766
41Anencephaly (HP:0002323)2.31598396
42Abnormality of abdominal situs (HP:0011620)2.26925270
43Abdominal situs inversus (HP:0003363)2.26925270
44Optic nerve hypoplasia (HP:0000609)2.25678726
45Aplasia/hypoplasia of the uterus (HP:0008684)2.25428426
46Partial duplication of thumb phalanx (HP:0009944)2.24782486
47Preaxial hand polydactyly (HP:0001177)2.22820264
48Aplasia/Hypoplasia of the sternum (HP:0006714)2.18961377
49Median cleft lip (HP:0000161)2.16554476
50Oligodactyly (HP:0012165)2.15946082
51Hyperglycinemia (HP:0002154)2.15431038
52Sloping forehead (HP:0000340)2.15024212
53Ectopic kidney (HP:0000086)2.14437906
54Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.11232906
55Rectal fistula (HP:0100590)2.10948314
56Rectovaginal fistula (HP:0000143)2.10948314
57Labial hypoplasia (HP:0000066)2.10819967
58Short hallux (HP:0010109)2.08602825
59Preaxial foot polydactyly (HP:0001841)2.08335515
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.08288665
61Hypoplastic female external genitalia (HP:0012815)2.06501451
62Hyperventilation (HP:0002883)2.06320883
63Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05976696
64Birth length less than 3rd percentile (HP:0003561)2.05702848
65Partial duplication of the phalanx of hand (HP:0009999)2.02151827
66Aplasia/Hypoplasia of the hallux (HP:0008362)2.01405278
67Impulsivity (HP:0100710)1.98900703
68Aqueductal stenosis (HP:0002410)1.98208555
69Cystic liver disease (HP:0006706)1.98097264
70Increased nuchal translucency (HP:0010880)1.97548133
71Abnormality of the middle phalanges of the toes (HP:0010183)1.96827811
72Maternal diabetes (HP:0009800)1.96335867
73Stenosis of the external auditory canal (HP:0000402)1.96128212
74Poor coordination (HP:0002370)1.92800612
75Micropenis (HP:0000054)1.87535890
76Carpal bone hypoplasia (HP:0001498)1.87147308
77Genital tract atresia (HP:0001827)1.86514129
78Molar tooth sign on MRI (HP:0002419)1.85211450
79Abnormality of midbrain morphology (HP:0002418)1.85211450
80Ependymoma (HP:0002888)1.85055751
81Aplasia involving bones of the upper limbs (HP:0009823)1.84687992
82Aplasia of the phalanges of the hand (HP:0009802)1.84687992
83Aplasia involving bones of the extremities (HP:0009825)1.84687992
84Facial cleft (HP:0002006)1.84612589
85Duplication of thumb phalanx (HP:0009942)1.84245818
86Renal cortical cysts (HP:0000803)1.83057452
87Abnormality of the labia (HP:0000058)1.82986495
88Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.82401726
89Congenital sensorineural hearing impairment (HP:0008527)1.80825946
90Abnormality of the carotid arteries (HP:0005344)1.80660525
91Male pseudohermaphroditism (HP:0000037)1.79545754
922-3 toe syndactyly (HP:0004691)1.78925453
93Bile duct proliferation (HP:0001408)1.77374045
94Abnormal biliary tract physiology (HP:0012439)1.77374045
95Abnormality of the renal cortex (HP:0011035)1.76326752
96Sclerocornea (HP:0000647)1.75096297
97Cupped ear (HP:0000378)1.73771321
98Embryonal neoplasm (HP:0002898)1.73524369
99Astigmatism (HP:0000483)1.73024475
100Pendular nystagmus (HP:0012043)1.71289285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.20701781
2WNK34.01878019
3TTK3.71547278
4NEK13.23476862
5BRSK22.92831357
6FRK2.76213990
7PLK42.56018642
8EIF2AK32.49076654
9ERBB42.30070213
10PBK2.17173083
11TRIM282.14296992
12CDK192.12211134
13MARK12.01047149
14NUAK12.00167363
15MKNK11.94248308
16PLK31.79381698
17BRSK11.72307020
18NEK21.70612403
19ZAK1.69894245
20STK31.69217621
21MST41.62546279
22CCNB11.60111023
23PLK11.55598111
24MET1.49896503
25CHEK21.47489851
26CDC71.43546434
27MKNK21.37965626
28SRPK11.34384406
29BRD41.31871798
30STK391.31514726
31STK241.28476969
32STK38L1.27062844
33PNCK1.18877002
34ACVR1B1.18265979
35LATS11.16878273
36PKN11.16456478
37BRAF1.09821233
38WEE11.01930139
39CASK0.97906027
40MAPK130.96066285
41STK40.95986725
42DYRK20.94713057
43AURKB0.92257039
44DMPK0.90965341
45TAF10.88671264
46VRK10.86915477
47RPS6KA50.86890049
48CDK70.86247743
49CHEK10.86152397
50YES10.85998922
51VRK20.84868918
52INSRR0.84237107
53OXSR10.79809725
54LATS20.79155363
55FLT30.77743617
56PLK20.77600988
57EIF2AK20.74127762
58ATM0.72117938
59AURKA0.71791427
60STK160.71555325
61BMPR1B0.70507000
62TNIK0.67235358
63MAP4K20.63740190
64WNK40.63535842
65FGFR20.63301189
66MELK0.60342538
67CDK10.57431464
68NTRK10.56663946
69CDK20.56455470
70ATR0.52490080
71CSNK1G20.52355838
72CAMK1G0.52181848
73NEK60.51866555
74MARK30.51586745
75CDK120.50786417
76CDK30.49586863
77PRKDC0.48583966
78TSSK60.48166131
79FGFR10.47358258
80MAPKAPK50.47191801
81TGFBR10.46470722
82GRK10.44765035
83ROCK10.44153055
84PINK10.44008214
85CDK80.43934116
86PDK20.43322357
87DYRK30.43227565
88PRKACB0.40494137
89MAP3K90.39779487
90PDGFRA0.37858288
91TLK10.37713975
92GSK3B0.34353342
93TYRO30.32998234
94PRKG10.32823694
95PRKCE0.32774057
96CSNK2A10.32630308
97NEK90.32212299
98CSNK1G10.30771449
99PRKCI0.30740863
100RPS6KA10.30607483

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.49134351
2Mismatch repair_Homo sapiens_hsa034303.23075262
3Non-homologous end-joining_Homo sapiens_hsa034503.12377218
4Homologous recombination_Homo sapiens_hsa034402.89513944
5RNA polymerase_Homo sapiens_hsa030202.88847089
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.75282886
7Cell cycle_Homo sapiens_hsa041102.63340952
8DNA replication_Homo sapiens_hsa030302.62932052
9Ribosome_Homo sapiens_hsa030102.51507965
10RNA transport_Homo sapiens_hsa030132.48846666
11Proteasome_Homo sapiens_hsa030502.47477640
12Fanconi anemia pathway_Homo sapiens_hsa034602.46724919
13RNA degradation_Homo sapiens_hsa030182.42166902
14Nucleotide excision repair_Homo sapiens_hsa034202.02977713
15Selenocompound metabolism_Homo sapiens_hsa004501.97744312
16Spliceosome_Homo sapiens_hsa030401.93718008
17Base excision repair_Homo sapiens_hsa034101.88691247
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.79838480
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79282409
20mRNA surveillance pathway_Homo sapiens_hsa030151.69443104
21Propanoate metabolism_Homo sapiens_hsa006401.67246461
22Oocyte meiosis_Homo sapiens_hsa041141.48640409
23Huntingtons disease_Homo sapiens_hsa050161.47099788
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46909136
25Protein export_Homo sapiens_hsa030601.41091634
26p53 signaling pathway_Homo sapiens_hsa041151.34259330
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33785884
28Linoleic acid metabolism_Homo sapiens_hsa005911.30601725
29Basal cell carcinoma_Homo sapiens_hsa052171.29909844
30Folate biosynthesis_Homo sapiens_hsa007901.28140422
31TGF-beta signaling pathway_Homo sapiens_hsa043501.23858788
32Fat digestion and absorption_Homo sapiens_hsa049751.20909910
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20139969
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20061030
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18177885
36Hippo signaling pathway_Homo sapiens_hsa043901.06490678
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05445134
38Ether lipid metabolism_Homo sapiens_hsa005651.05291896
39Parkinsons disease_Homo sapiens_hsa050121.04844733
40One carbon pool by folate_Homo sapiens_hsa006701.04098478
41Phototransduction_Homo sapiens_hsa047441.04082087
42Oxidative phosphorylation_Homo sapiens_hsa001901.03662834
43Lysine degradation_Homo sapiens_hsa003101.03393952
44Pyrimidine metabolism_Homo sapiens_hsa002401.02340837
45Pyruvate metabolism_Homo sapiens_hsa006200.98220694
46Butanoate metabolism_Homo sapiens_hsa006500.94953819
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94483992
48Wnt signaling pathway_Homo sapiens_hsa043100.93662873
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86092230
50Nicotine addiction_Homo sapiens_hsa050330.86039108
51Purine metabolism_Homo sapiens_hsa002300.84272989
52Regulation of autophagy_Homo sapiens_hsa041400.84109855
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81265282
54Ovarian steroidogenesis_Homo sapiens_hsa049130.80825688
55MicroRNAs in cancer_Homo sapiens_hsa052060.74398695
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73955078
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72220348
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71948029
59Hedgehog signaling pathway_Homo sapiens_hsa043400.70234961
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62458775
61Vitamin digestion and absorption_Homo sapiens_hsa049770.61789256
62Vitamin B6 metabolism_Homo sapiens_hsa007500.59472342
63Arachidonic acid metabolism_Homo sapiens_hsa005900.53431824
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50703332
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50101644
66Taste transduction_Homo sapiens_hsa047420.48608766
67Cardiac muscle contraction_Homo sapiens_hsa042600.47307915
68Circadian rhythm_Homo sapiens_hsa047100.46985884
69Metabolic pathways_Homo sapiens_hsa011000.46913245
70Olfactory transduction_Homo sapiens_hsa047400.45340612
71Melanoma_Homo sapiens_hsa052180.45109584
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44856306
73Calcium signaling pathway_Homo sapiens_hsa040200.44567289
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43927270
75beta-Alanine metabolism_Homo sapiens_hsa004100.43577797
76Steroid biosynthesis_Homo sapiens_hsa001000.42660918
77Arginine and proline metabolism_Homo sapiens_hsa003300.41125593
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.40990605
79Alzheimers disease_Homo sapiens_hsa050100.39617056
80Glutathione metabolism_Homo sapiens_hsa004800.38639988
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34840747
82Adherens junction_Homo sapiens_hsa045200.32685790
83Tight junction_Homo sapiens_hsa045300.32524081
84Serotonergic synapse_Homo sapiens_hsa047260.32023740
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29765063
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29066538
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.28733565
88Dorso-ventral axis formation_Homo sapiens_hsa043200.27134251
89Biosynthesis of amino acids_Homo sapiens_hsa012300.26803758
90Nitrogen metabolism_Homo sapiens_hsa009100.26772331
91ECM-receptor interaction_Homo sapiens_hsa045120.26491901
92Melanogenesis_Homo sapiens_hsa049160.26156369
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25884850
94Pathways in cancer_Homo sapiens_hsa052000.25144147
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.24681392
96Glycerolipid metabolism_Homo sapiens_hsa005610.23944089
97Retinol metabolism_Homo sapiens_hsa008300.22421831
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21504031
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20263998
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.19933634

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