ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA replication checkpoint (GO:0000076)	4.38511326
2	chromatin remodeling at centromere (GO:0031055)	4.11884483
3	regulation of centriole replication (GO:0046599)	4.11049048
4	regulation of mitotic spindle organization (GO:0060236)	4.10874554
5	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.94409943
6	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.94409943
7	regulation of translation, ncRNA-mediated (GO:0045974)	3.94409943
8	DNA double-strand break processing (GO:0000729)	3.91058888
9	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.89047165
10	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	3.62485996
11	CENP-A containing nucleosome assembly (GO:0034080)	3.56661284
12	regulation of spindle organization (GO:0090224)	3.56188008
13	regulation of gene silencing by RNA (GO:0060966)	3.54939376
14	regulation of posttranscriptional gene silencing (GO:0060147)	3.54939376
15	regulation of gene silencing by miRNA (GO:0060964)	3.54939376
16	lateral sprouting from an epithelium (GO:0060601)	3.40420366
17	regulation of mitotic spindle checkpoint (GO:1903504)	3.38557438
18	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.38557438
19	regulation of hippo signaling (GO:0035330)	3.32616246
20	otic vesicle formation (GO:0030916)	3.31918888
21	neuron remodeling (GO:0016322)	3.30240717
22	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.28864713
23	S-adenosylmethionine metabolic process (GO:0046500)	3.27089153
24	hindbrain development (GO:0030902)	3.15828280
25	histone exchange (GO:0043486)	3.13940719
26	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	3.11244686
27	regulation of transforming growth factor beta2 production (GO:0032909)	3.11231945
28	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.09517341
29	heterochromatin organization (GO:0070828)	3.06713650
30	centriole replication (GO:0007099)	3.02962825
31	protein K6-linked ubiquitination (GO:0085020)	3.02190780
32	nodal signaling pathway (GO:0038092)	3.01482650
33	intestinal epithelial cell development (GO:0060576)	2.90007077
34	pituitary gland development (GO:0021983)	2.88647842
35	limb bud formation (GO:0060174)	2.82369600
36	axoneme assembly (GO:0035082)	2.79398847
37	replication fork processing (GO:0031297)	2.79197503
38	generation of neurons (GO:0048699)	2.76296459
39	pyrimidine dimer repair (GO:0006290)	2.75350924
40	head development (GO:0060322)	2.74701134
41	atrial cardiac muscle cell action potential (GO:0086014)	2.74629007
42	dorsal/ventral axis specification (GO:0009950)	2.74410455
43	kinetochore organization (GO:0051383)	2.73611591
44	regulation of centrosome cycle (GO:0046605)	2.73597320
45	regulation of meiosis I (GO:0060631)	2.72608713
46	DNA replication-dependent nucleosome assembly (GO:0006335)	2.72367713
47	DNA replication-dependent nucleosome organization (GO:0034723)	2.72367713
48	DNA replication-independent nucleosome organization (GO:0034724)	2.71448492
49	DNA replication-independent nucleosome assembly (GO:0006336)	2.71448492
50	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.71070628
51	regulation of helicase activity (GO:0051095)	2.70829669
52	double-strand break repair via homologous recombination (GO:0000724)	2.70436947
53	regulation of centrosome duplication (GO:0010824)	2.70406303
54	mitotic sister chromatid cohesion (GO:0007064)	2.69426969
55	recombinational repair (GO:0000725)	2.69372385
56	ncRNA catabolic process (GO:0034661)	2.68193989
57	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.67640035
58	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.67640035
59	cell fate commitment involved in formation of primary germ layer (GO:0060795)	2.67416434
60	kinetochore assembly (GO:0051382)	2.66584346
61	prenylation (GO:0097354)	2.65301639
62	protein prenylation (GO:0018342)	2.65301639
63	genitalia morphogenesis (GO:0035112)	2.61223079
64	establishment of tissue polarity (GO:0007164)	2.59898339
65	establishment of planar polarity (GO:0001736)	2.59898339
66	protein K11-linked deubiquitination (GO:0035871)	2.59452287
67	response to X-ray (GO:0010165)	2.57178221
68	behavioral response to nicotine (GO:0035095)	2.56883908
69	sulfation (GO:0051923)	2.56851580
70	positive regulation of mRNA processing (GO:0050685)	2.56069549
71	attachment of spindle microtubules to kinetochore (GO:0008608)	2.54241574
72	DNA-dependent DNA replication (GO:0006261)	2.54127538
73	intra-S DNA damage checkpoint (GO:0031573)	2.51608810
74	left/right axis specification (GO:0070986)	2.48626385
75	protein localization to kinetochore (GO:0034501)	2.48357246
76	nuclear pore organization (GO:0006999)	2.48334708
77	epithelial cilium movement (GO:0003351)	2.46424213
78	regulation of DNA endoreduplication (GO:0032875)	2.46070409
79	protein neddylation (GO:0045116)	2.45147346
80	negative regulation of RNA splicing (GO:0033119)	2.45017906
81	negative regulation of keratinocyte proliferation (GO:0010839)	2.43710243
82	DNA catabolic process, exonucleolytic (GO:0000738)	2.43092562
83	negative regulation of mRNA processing (GO:0050686)	2.42970203
84	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.42567671
85	regulation of mRNA splicing, via spliceosome (GO:0048024)	2.41163338
86	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.40397731
87	kidney morphogenesis (GO:0060993)	2.38896443
88	negative regulation of neurotransmitter secretion (GO:0046929)	2.38834971
89	organ formation (GO:0048645)	2.38459610
90	rRNA catabolic process (GO:0016075)	2.37555816
91	tRNA modification (GO:0006400)	2.36420381
92	substrate-dependent cell migration (GO:0006929)	2.35603015
93	tRNA processing (GO:0008033)	2.35533149
94	cullin deneddylation (GO:0010388)	2.35399125
95	positive regulation of SMAD protein import into nucleus (GO:0060391)	2.33983890
96	postreplication repair (GO:0006301)	2.33591504
97	embryonic pattern specification (GO:0009880)	2.32301618
98	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	2.31597111
99	mitochondrial DNA replication (GO:0006264)	2.31090309
100	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.30949328

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.55198911
2	* ZNF274_21170338_ChIP-Seq_K562_Hela	2.92864538
3	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.65853829
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.62332731
5	FUS_26573619_Chip-Seq_HEK293_Human	2.57075046
6	EWS_26573619_Chip-Seq_HEK293_Human	2.54394415
7	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.50789968
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.49769569
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.45979560
10	E2F7_22180533_ChIP-Seq_HELA_Human	2.41683317
11	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.37911566
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.32768940
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.29826149
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.26386141
15	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.17133129
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14643980
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.08031795
18	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.05865901
19	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.02978647
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.01194443
21	VDR_22108803_ChIP-Seq_LS180_Human	1.99578468
22	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.98223113
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.95733637
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.94841138
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.93056858
26	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.83594831
27	P300_19829295_ChIP-Seq_ESCs_Human	1.78404124
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.71997288
29	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.69927756
30	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.66532483
31	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.65247681
32	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.63484829
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.61084608
34	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.60491581
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.57955359
36	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55767584
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.55429919
38	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.54746920
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.50215155
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.49733872
41	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.49130410
42	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.49100240
43	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.44065982
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.40890821
45	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39092363
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.35574974
47	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.31119752
48	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30752453
49	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.30188543
50	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.28745798
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.28136932
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26621735
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26295883
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24083452
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24059027
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.23664638
57	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.21111232
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20434256
59	IRF1_19129219_ChIP-ChIP_H3396_Human	1.20109573
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.19178157
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.19178157
62	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.16112047
63	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14631452
64	IGF1R_20145208_ChIP-Seq_DFB_Human	1.14467309
65	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.12888931
66	ER_23166858_ChIP-Seq_MCF-7_Human	1.12373396
67	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11536573
68	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.10115740
69	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.09850324
70	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09622611
71	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08730556
72	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.07588372
73	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.06891755
74	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06773571
75	AR_21909140_ChIP-Seq_LNCAP_Human	1.05648359
76	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.05416001
77	STAT3_23295773_ChIP-Seq_U87_Human	1.03325615
78	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.02573881
79	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02330137
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02156322
81	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.02087284
82	AR_25329375_ChIP-Seq_VCAP_Human	1.02041897
83	RNF2_27304074_Chip-Seq_NSC_Mouse	1.01500532
84	* TCF4_23295773_ChIP-Seq_U87_Human	1.00981336
85	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.00400374
86	BCAT_22108803_ChIP-Seq_LS180_Human	1.00349081
87	FOXP3_21729870_ChIP-Seq_TREG_Human	0.99992247
88	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.98882517
89	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98803203
90	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.98182212
91	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.97749263
92	* DCP1A_22483619_ChIP-Seq_HELA_Human	0.97418158
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97157718
94	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.96821951
95	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.96780193
96	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96780193
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96379544
98	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.96376439
99	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.96075313
100	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.95969366

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	3.14034566
2	MP0002160_abnormal_reproductive_system	2.95002709
3	MP0008057_abnormal_DNA_replication	2.80051963
4	MP0008058_abnormal_DNA_repair	2.41136671
5	MP0008877_abnormal_DNA_methylation	2.40800486
6	MP0004133_heterotaxia	2.37119101
7	MP0000537_abnormal_urethra_morphology	2.29261738
8	MP0000516_abnormal_urinary_system	2.21202946
9	MP0005367_renal/urinary_system_phenotyp	2.21202946
10	MP0003937_abnormal_limbs/digits/tail_de	2.06964340
11	MP0010094_abnormal_chromosome_stability	2.03920241
12	MP0006292_abnormal_olfactory_placode	2.01725266
13	MP0003890_abnormal_embryonic-extraembry	2.01343649
14	MP0003941_abnormal_skin_development	1.97896976
15	MP0001919_abnormal_reproductive_system	1.94548180
16	MP0003119_abnormal_digestive_system	1.92948003
17	MP0001188_hyperpigmentation	1.91348924
18	MP0000049_abnormal_middle_ear	1.89923126
19	MP0001727_abnormal_embryo_implantation	1.89064129
20	MP0001293_anophthalmia	1.84284451
21	MP0003718_maternal_effect	1.75770790
22	MP0009053_abnormal_anal_canal	1.73910562
23	MP0000427_abnormal_hair_cycle	1.69789728
24	MP0003136_yellow_coat_color	1.69072940
25	MP0003755_abnormal_palate_morphology	1.66670732
26	MP0010030_abnormal_orbit_morphology	1.63397619
27	MP0005389_reproductive_system_phenotype	1.62108732
28	MP0003111_abnormal_nucleus_morphology	1.59154844
29	MP0001286_abnormal_eye_development	1.58462277
30	MP0002102_abnormal_ear_morphology	1.57881817
31	MP0000631_abnormal_neuroendocrine_gland	1.56288027
32	MP0003195_calcinosis	1.55239156
33	MP0002254_reproductive_system_inflammat	1.54230618
34	MP0002638_abnormal_pupillary_reflex	1.49086529
35	MP0002282_abnormal_trachea_morphology	1.47212347
36	MP0003077_abnormal_cell_cycle	1.47108586
37	MP0006072_abnormal_retinal_apoptosis	1.45785379
38	MP0000566_synostosis	1.42222624
39	MP0004957_abnormal_blastocyst_morpholog	1.33285829
40	MP0002234_abnormal_pharynx_morphology	1.30830347
41	MP0002938_white_spotting	1.29359256
42	MP0003121_genomic_imprinting	1.28706237
43	MP0002084_abnormal_developmental_patter	1.27124476
44	MP0009250_abnormal_appendicular_skeleto	1.26405696
45	MP0002111_abnormal_tail_morphology	1.26129114
46	MP0005248_abnormal_Harderian_gland	1.25996555
47	MP0004147_increased_porphyrin_level	1.24963363
48	MP0008932_abnormal_embryonic_tissue	1.23442581
49	MP0005551_abnormal_eye_electrophysiolog	1.22642005
50	MP0002233_abnormal_nose_morphology	1.22384513
51	MP0000613_abnormal_salivary_gland	1.21306438
52	MP0008789_abnormal_olfactory_epithelium	1.20408444
53	MP0002751_abnormal_autonomic_nervous	1.19858807
54	MP0001529_abnormal_vocalization	1.19580213
55	MP0002697_abnormal_eye_size	1.18276732
56	MP0003935_abnormal_craniofacial_develop	1.16088929
57	MP0005187_abnormal_penis_morphology	1.15237115
58	MP0000428_abnormal_craniofacial_morphol	1.13664527
59	MP0000778_abnormal_nervous_system	1.13217903
60	MP0000647_abnormal_sebaceous_gland	1.12818661
61	MP0000383_abnormal_hair_follicle	1.12545314
62	MP0009697_abnormal_copulation	1.11145351
63	MP0008007_abnormal_cellular_replicative	1.08905678
64	MP0000432_abnormal_head_morphology	1.06580464
65	MP0002085_abnormal_embryonic_tissue	1.05768041
66	MP0001299_abnormal_eye_distance/	1.04349164
67	MP0003861_abnormal_nervous_system	0.99148283
68	MP0003567_abnormal_fetal_cardiomyocyte	0.98728294
69	MP0005253_abnormal_eye_physiology	0.97876644
70	MP0003122_maternal_imprinting	0.96988473
71	MP0002109_abnormal_limb_morphology	0.95991589
72	MP0000579_abnormal_nail_morphology	0.94119784
73	MP0009703_decreased_birth_body	0.93937602
74	MP0001485_abnormal_pinna_reflex	0.93845644
75	MP0003786_premature_aging	0.93468089
76	MP0004043_abnormal_pH_regulation	0.92998339
77	MP0009384_cardiac_valve_regurgitation	0.91779768
78	MP0000538_abnormal_urinary_bladder	0.91609214
79	MP0001145_abnormal_male_reproductive	0.89667259
80	MP0010352_gastrointestinal_tract_polyps	0.89243125
81	MP0005380_embryogenesis_phenotype	0.88932354
82	MP0001672_abnormal_embryogenesis/_devel	0.88932354
83	MP0001346_abnormal_lacrimal_gland	0.88612857
84	MP0010678_abnormal_skin_adnexa	0.88268882
85	MP0005395_other_phenotype	0.88178036
86	MP0004197_abnormal_fetal_growth/weight/	0.87889480
87	MP0002210_abnormal_sex_determination	0.86549708
88	MP0001697_abnormal_embryo_size	0.86477981
89	MP0003936_abnormal_reproductive_system	0.85989082
90	MP0001929_abnormal_gametogenesis	0.85674953
91	MP0000653_abnormal_sex_gland	0.84661160
92	MP0005391_vision/eye_phenotype	0.84296371
93	MP0003315_abnormal_perineum_morphology	0.83498478
94	MP0002116_abnormal_craniofacial_bone	0.81009699
95	MP0003984_embryonic_growth_retardation	0.78157775
96	MP0000762_abnormal_tongue_morphology	0.78103299
97	MP0005394_taste/olfaction_phenotype	0.77781526
98	MP0005499_abnormal_olfactory_system	0.77781526
99	MP0001177_atelectasis	0.77477256
100	MP0002088_abnormal_embryonic_growth/wei	0.77274455

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperinsulinemic hypoglycemia (HP:0000825)	3.79539707
2	Colon cancer (HP:0003003)	3.59176360
3	Abnormality of midbrain morphology (HP:0002418)	3.37135883
4	Molar tooth sign on MRI (HP:0002419)	3.37135883
5	Abnormality of chromosome stability (HP:0003220)	3.23439256
6	Pancreatic cysts (HP:0001737)	3.14204105
7	Abnormality of the labia minora (HP:0012880)	3.13809172
8	Gonadotropin excess (HP:0000837)	3.10216415
9	Ectopic kidney (HP:0000086)	2.98795873
10	Chromsome breakage (HP:0040012)	2.93213644
11	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.85414524
12	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.80515773
13	Nephronophthisis (HP:0000090)	2.67446250
14	Meckel diverticulum (HP:0002245)	2.66718149
15	True hermaphroditism (HP:0010459)	2.64307523
16	Septo-optic dysplasia (HP:0100842)	2.63154537
17	Chronic hepatic failure (HP:0100626)	2.62593076
18	Pancreatic fibrosis (HP:0100732)	2.58220503
19	Abnormality of the ileum (HP:0001549)	2.54909356
20	Optic nerve hypoplasia (HP:0000609)	2.53014765
21	Curly hair (HP:0002212)	2.44657308
22	Abnormality of the renal medulla (HP:0100957)	2.36273341
23	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.29510804
24	Abnormality of the preputium (HP:0100587)	2.27847553
25	Depressed nasal tip (HP:0000437)	2.23766387
26	Supernumerary spleens (HP:0009799)	2.17779713
27	Facial cleft (HP:0002006)	2.17254785
28	Absent radius (HP:0003974)	2.13849466
29	Birth length less than 3rd percentile (HP:0003561)	2.11580969
30	Duodenal stenosis (HP:0100867)	2.11213580
31	Small intestinal stenosis (HP:0012848)	2.11213580
32	Anophthalmia (HP:0000528)	2.11014353
33	Sloping forehead (HP:0000340)	2.09136862
34	Abnormality of the duodenum (HP:0002246)	2.04985065
35	Aplasia involving forearm bones (HP:0009822)	2.04891892
36	Absent forearm bone (HP:0003953)	2.04891892
37	Partial agenesis of the corpus callosum (HP:0001338)	2.01811891
38	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.00872841
39	Absent eyebrow (HP:0002223)	1.99183962
40	Median cleft lip (HP:0000161)	1.98491226
41	Myelodysplasia (HP:0002863)	1.98217544
42	Triphalangeal thumb (HP:0001199)	1.93380119
43	Esophageal atresia (HP:0002032)	1.93167726
44	Neoplasm of the adrenal cortex (HP:0100641)	1.92572448
45	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.91985604
46	Gastrointestinal atresia (HP:0002589)	1.91913693
47	Exertional dyspnea (HP:0002875)	1.91856284
48	Small hand (HP:0200055)	1.89006593
49	Abnormality of the renal cortex (HP:0011035)	1.86824892
50	Microretrognathia (HP:0000308)	1.85751463
51	Congenital stationary night blindness (HP:0007642)	1.83675955
52	Nephroblastoma (Wilms tumor) (HP:0002667)	1.83558500
53	Anencephaly (HP:0002323)	1.80189771
54	Hypoplasia of the pons (HP:0012110)	1.80014778
55	Preaxial foot polydactyly (HP:0001841)	1.78502515
56	Hypoplastic labia majora (HP:0000059)	1.77101113
57	2-3 toe syndactyly (HP:0004691)	1.77016871
58	Abnormality of the pons (HP:0007361)	1.76337900
59	Narrow forehead (HP:0000341)	1.75755580
60	Medial flaring of the eyebrow (HP:0010747)	1.75569005
61	Clubbing of toes (HP:0100760)	1.75182433
62	Abnormality of the carotid arteries (HP:0005344)	1.75123703
63	Abnormal number of incisors (HP:0011064)	1.74775931
64	Embryonal renal neoplasm (HP:0011794)	1.74172987
65	Abnormal lung lobation (HP:0002101)	1.72679022
66	Intestinal atresia (HP:0011100)	1.72281240
67	Aplasia/Hypoplasia of the breasts (HP:0010311)	1.71633656
68	Progressive inability to walk (HP:0002505)	1.71628716
69	Tubular atrophy (HP:0000092)	1.71241170
70	Attenuation of retinal blood vessels (HP:0007843)	1.70533483
71	Preaxial hand polydactyly (HP:0001177)	1.70016980
72	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.69584844
73	Breast carcinoma (HP:0003002)	1.68922588
74	Genital tract atresia (HP:0001827)	1.68889526
75	Breast hypoplasia (HP:0003187)	1.68532411
76	Postaxial hand polydactyly (HP:0001162)	1.68346691
77	Lissencephaly (HP:0001339)	1.68119819
78	Abnormality of the middle phalanges of the toes (HP:0010183)	1.67672615
79	Short hallux (HP:0010109)	1.66897236
80	Absent eyelashes (HP:0000561)	1.66025579
81	Midline defect of the nose (HP:0004122)	1.65185880
82	Fibular aplasia (HP:0002990)	1.64800265
83	Vaginal atresia (HP:0000148)	1.64180559
84	Aplasia/Hypoplasia of the patella (HP:0006498)	1.63575550
85	Shawl scrotum (HP:0000049)	1.63549127
86	Breast aplasia (HP:0100783)	1.60960225
87	Postaxial foot polydactyly (HP:0001830)	1.60573493
88	Abnormality of the labia majora (HP:0012881)	1.60398293
89	Gastrointestinal carcinoma (HP:0002672)	1.60392058
90	Malignant gastrointestinal tract tumors (HP:0006749)	1.60392058
91	Abnormality of abdominal situs (HP:0011620)	1.59494772
92	Abdominal situs inversus (HP:0003363)	1.59494772
93	Hyperglycinemia (HP:0002154)	1.59464592
94	Broad-based gait (HP:0002136)	1.59315166
95	Abnormality of the septum pellucidum (HP:0007375)	1.58891361
96	Short tibia (HP:0005736)	1.58515651
97	Patellar aplasia (HP:0006443)	1.58466370
98	Epidermoid cyst (HP:0200040)	1.57393229
99	Duplicated collecting system (HP:0000081)	1.57281290
100	Hyperalaninemia (HP:0003348)	1.57006552

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	4.56723763
2	PNCK	4.46493887
3	AKT3	3.90114352
4	WEE1	3.48613882
5	BRSK2	3.41054782
6	TTK	2.73125083
7	GRK1	2.65531815
8	CDK9	2.55751200
9	FRK	2.47291053
10	PLK4	2.41856267
11	NLK	2.41171415
12	ERBB4	2.31036426
13	MKNK2	2.22899331
14	ZAK	2.17142131
15	EIF2AK3	2.12367669
16	CDC7	2.09602711
17	WNK3	1.76705040
18	NUAK1	1.73434892
19	VRK1	1.72725414
20	STK38L	1.70339486
21	SRPK1	1.66229085
22	TAF1	1.46399581
23	MKNK1	1.44964340
24	BMPR1B	1.43122226
25	PLK3	1.40000112
26	TRIM28	1.38863134
27	TSSK6	1.32123581
28	BUB1	1.25953155
29	CAMK1G	1.24433054
30	EPHB2	1.23075100
31	BRD4	1.19478446
32	VRK2	1.14826583
33	MELK	1.13731691
34	LATS1	1.12920035
35	TLK1	1.11278239
36	PLK1	1.09548560
37	DYRK3	1.07333451
38	DYRK2	1.03286187
39	BRSK1	1.01133625
40	CHEK2	1.00846885
41	ERBB3	1.00401595
42	BRAF	0.97626906
43	SGK2	0.90934739
44	CASK	0.89989957
45	STK3	0.88720539
46	PRKCE	0.87106549
47	EPHA3	0.85315917
48	ACVR1B	0.83869690
49	ATR	0.83144265
50	TGFBR1	0.78019729
51	WNK4	0.76671192
52	BCR	0.76220297
53	MAP4K2	0.75787976
54	CSNK1G1	0.74397212
55	MST4	0.71907476
56	STK24	0.67892568
57	STK39	0.66501209
58	PRKCG	0.65749479
59	FGFR2	0.65227646
60	ATM	0.63982996
61	OXSR1	0.63964356
62	CDK8	0.63410437
63	ADRBK2	0.57533512
64	INSRR	0.56025273
65	EIF2AK1	0.54285018
66	CSNK1G2	0.53497364
67	CSNK1A1L	0.53178978
68	CAMK1D	0.51584969
69	FGFR1	0.50339917
70	EPHA2	0.49800750
71	PLK2	0.48718890
72	RPS6KA4	0.47322307
73	CSNK1G3	0.47024941
74	CSNK1E	0.46845989
75	SGK494	0.41900119
76	SGK223	0.41900119
77	CDK3	0.40573370
78	EIF2AK2	0.40407615
79	CHEK1	0.39796459
80	FER	0.39393421
81	STK16	0.39058021
82	CSNK2A1	0.38280979
83	SGK3	0.38232612
84	DYRK1A	0.37051596
85	AURKB	0.36729924
86	PINK1	0.35865173
87	PDK2	0.35099741
88	NEK1	0.29174950
89	MAPK13	0.29062157
90	PAK3	0.27822364
91	TIE1	0.27213713
92	MAP3K4	0.26410662
93	NEK2	0.26380815
94	EPHA4	0.25541863
95	YES1	0.25384404
96	PASK	0.24995714
97	MARK1	0.24271701
98	CSNK2A2	0.22228370
99	CSNK1D	0.22010865
100	PIK3CA	0.20249956

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.50149645
2	Selenocompound metabolism_Homo sapiens_hsa00450	2.96798529
3	Fanconi anemia pathway_Homo sapiens_hsa03460	2.96078203
4	Non-homologous end-joining_Homo sapiens_hsa03450	2.92597953
5	Basal transcription factors_Homo sapiens_hsa03022	2.80616866
6	Homologous recombination_Homo sapiens_hsa03440	2.43657122
7	RNA transport_Homo sapiens_hsa03013	2.39789520
8	RNA degradation_Homo sapiens_hsa03018	2.38636244
9	Mismatch repair_Homo sapiens_hsa03430	2.23260976
10	Protein export_Homo sapiens_hsa03060	2.21919450
11	RNA polymerase_Homo sapiens_hsa03020	2.21131805
12	Basal cell carcinoma_Homo sapiens_hsa05217	2.16019945
13	p53 signaling pathway_Homo sapiens_hsa04115	1.95819797
14	DNA replication_Homo sapiens_hsa03030	1.94794475
15	Nucleotide excision repair_Homo sapiens_hsa03420	1.82072808
16	Lysine degradation_Homo sapiens_hsa00310	1.81320538
17	Cell cycle_Homo sapiens_hsa04110	1.77139839
18	One carbon pool by folate_Homo sapiens_hsa00670	1.76549719
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.71856720
20	Hippo signaling pathway_Homo sapiens_hsa04390	1.66697030
21	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.63617068
22	Spliceosome_Homo sapiens_hsa03040	1.63602671
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.61501016
24	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.58145123
25	Phototransduction_Homo sapiens_hsa04744	1.49632960
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.48550588
27	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.45723792
28	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.38470774
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.28275233
30	Propanoate metabolism_Homo sapiens_hsa00640	1.26653181
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.22015576
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.21283763
33	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.19188531
34	Thyroid cancer_Homo sapiens_hsa05216	1.18933705
35	Steroid biosynthesis_Homo sapiens_hsa00100	1.18665780
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.15039787
37	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.13933191
38	mRNA surveillance pathway_Homo sapiens_hsa03015	1.09351387
39	Base excision repair_Homo sapiens_hsa03410	1.07162333
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.06737986
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.04436889
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.00378597
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.99895457
44	Tight junction_Homo sapiens_hsa04530	0.95663106
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.93440935
46	Wnt signaling pathway_Homo sapiens_hsa04310	0.91499165
47	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.89649176
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.89195251
49	Prostate cancer_Homo sapiens_hsa05215	0.85857333
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.85198120
51	Ribosome_Homo sapiens_hsa03010	0.85111201
52	Caffeine metabolism_Homo sapiens_hsa00232	0.84871308
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.84245376
54	Circadian rhythm_Homo sapiens_hsa04710	0.81142258
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80602167
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.77127640
57	Melanoma_Homo sapiens_hsa05218	0.75845145
58	Butanoate metabolism_Homo sapiens_hsa00650	0.75792565
59	Alcoholism_Homo sapiens_hsa05034	0.71304445
60	Adherens junction_Homo sapiens_hsa04520	0.71008545
61	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.70024436
62	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.68482390
63	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.67769444
64	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.67304062
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66285779
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.66187894
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66119657
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.64194189
69	Taste transduction_Homo sapiens_hsa04742	0.64106122
70	Purine metabolism_Homo sapiens_hsa00230	0.64059116
71	MicroRNAs in cancer_Homo sapiens_hsa05206	0.63790322
72	Huntingtons disease_Homo sapiens_hsa05016	0.61849020
73	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.58039570
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54776713
75	Retinol metabolism_Homo sapiens_hsa00830	0.53865981
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.53357338
77	Nicotine addiction_Homo sapiens_hsa05033	0.52814535
78	Colorectal cancer_Homo sapiens_hsa05210	0.51160191
79	Olfactory transduction_Homo sapiens_hsa04740	0.50558718
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50243415
81	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.48974343
82	Cocaine addiction_Homo sapiens_hsa05030	0.48299867
83	Histidine metabolism_Homo sapiens_hsa00340	0.48154822
84	Sphingolipid metabolism_Homo sapiens_hsa00600	0.47601263
85	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47024784
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.46826810
87	Proteasome_Homo sapiens_hsa03050	0.45903065
88	Melanogenesis_Homo sapiens_hsa04916	0.45603529
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.44852220
90	Peroxisome_Homo sapiens_hsa04146	0.42884717
91	FoxO signaling pathway_Homo sapiens_hsa04068	0.42320270
92	Oocyte meiosis_Homo sapiens_hsa04114	0.41028646
93	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.40449069
94	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.40079437
95	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.39875449
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.38062850
97	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38042225
98	Metabolic pathways_Homo sapiens_hsa01100	0.37157086
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36936165
100	Oxidative phosphorylation_Homo sapiens_hsa00190	0.36202314

ZNF561

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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