ZNF562

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)7.95072155
2regulation of odontogenesis of dentin-containing tooth (GO:0042487)7.87949656
3protein-chromophore linkage (GO:0018298)7.60629327
4regulation of meiosis I (GO:0060631)7.37851521
5lipopolysaccharide biosynthetic process (GO:0009103)7.31810611
6regulation of pigment cell differentiation (GO:0050932)7.25922012
7positive regulation of developmental pigmentation (GO:0048087)7.11298410
8negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.76754791
9regulation of protein glycosylation (GO:0060049)6.65913635
10sulfate transmembrane transport (GO:1902358)6.57020379
11lipopolysaccharide metabolic process (GO:0008653)6.36471650
12negative regulation of cell cycle G2/M phase transition (GO:1902750)5.94818064
13negative regulation of glycoprotein biosynthetic process (GO:0010561)5.88945539
14piRNA metabolic process (GO:0034587)5.71272045
15sulfate transport (GO:0008272)5.67861015
16regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.54567127
17paraxial mesoderm development (GO:0048339)5.51567881
18SMAD protein complex assembly (GO:0007183)4.89915819
19L-phenylalanine catabolic process (GO:0006559)4.83100923
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.83100923
21heme transport (GO:0015886)4.68674811
22tyrosine metabolic process (GO:0006570)4.57854009
23gamma-aminobutyric acid signaling pathway (GO:0007214)4.49489075
24notochord development (GO:0030903)4.47918193
25centriole replication (GO:0007099)4.47786645
26meiotic chromosome segregation (GO:0045132)4.40779971
27nodal signaling pathway (GO:0038092)4.38546417
28positive regulation of meiosis (GO:0045836)4.37526809
29ribonucleoprotein complex disassembly (GO:0032988)4.31038640
30negative regulation of glycoprotein metabolic process (GO:1903019)4.17615649
31regulation of rhodopsin mediated signaling pathway (GO:0022400)4.09299191
32positive regulation of meiotic cell cycle (GO:0051446)4.07870578
33tachykinin receptor signaling pathway (GO:0007217)4.04200962
34regulation of nuclear cell cycle DNA replication (GO:0033262)3.99347912
35flavonoid metabolic process (GO:0009812)3.94063408
36L-phenylalanine metabolic process (GO:0006558)3.93347640
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.93347640
38serotonin receptor signaling pathway (GO:0007210)3.93209357
39regulation of transforming growth factor beta2 production (GO:0032909)3.84487701
40aromatic amino acid family catabolic process (GO:0009074)3.82963434
41rhodopsin mediated signaling pathway (GO:0016056)3.78447996
42regulation of developmental pigmentation (GO:0048070)3.75529750
43sympathetic nervous system development (GO:0048485)3.67857615
44negative regulation of stem cell proliferation (GO:2000647)3.60908087
45regulation of odontogenesis (GO:0042481)3.58275921
46DNA damage induced protein phosphorylation (GO:0006975)3.57466260
47glycerol metabolic process (GO:0006071)3.53172203
48vitamin transmembrane transport (GO:0035461)3.52138155
49organelle disassembly (GO:1903008)3.51136629
50cellular response to gamma radiation (GO:0071480)3.50446937
51epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.43798484
52regulation of interleukin-5 production (GO:0032674)3.39839510
53indolalkylamine metabolic process (GO:0006586)3.37396046
54iron coordination entity transport (GO:1901678)3.36036906
55aromatic amino acid family metabolic process (GO:0009072)3.32369745
56regulation of keratinocyte proliferation (GO:0010837)3.29739458
57sulfur compound transport (GO:0072348)3.28753879
58toxin metabolic process (GO:0009404)3.27857086
59pantothenate metabolic process (GO:0015939)3.24518104
60somite rostral/caudal axis specification (GO:0032525)3.22384819
61aspartate family amino acid catabolic process (GO:0009068)3.15919050
62germinal center formation (GO:0002467)3.11760279
63response to epinephrine (GO:0071871)3.08870175
64alditol metabolic process (GO:0019400)3.05195547
65positive regulation of fatty acid oxidation (GO:0046321)3.04645096
66DNA methylation (GO:0006306)3.04507835
67DNA alkylation (GO:0006305)3.04507835
68heart valve formation (GO:0003188)3.04300144
69negative regulation of DNA-dependent DNA replication (GO:2000104)3.02158546
70centriole assembly (GO:0098534)2.99720117
71regulation of hippo signaling (GO:0035330)2.96961915
72reciprocal meiotic recombination (GO:0007131)2.94512868
73reciprocal DNA recombination (GO:0035825)2.94512868
74indole-containing compound catabolic process (GO:0042436)2.93952333
75indolalkylamine catabolic process (GO:0046218)2.93952333
76tryptophan catabolic process (GO:0006569)2.93952333
77lysine catabolic process (GO:0006554)2.92990983
78lysine metabolic process (GO:0006553)2.92990983
79positive regulation of SMAD protein import into nucleus (GO:0060391)2.90805218
80regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.86058812
81urate metabolic process (GO:0046415)2.80579513
82response to mercury ion (GO:0046689)2.78411911
83negative regulation of cell-matrix adhesion (GO:0001953)2.78391457
84biotin metabolic process (GO:0006768)2.76327902
85phasic smooth muscle contraction (GO:0014821)2.75660522
86uterus development (GO:0060065)2.74287591
87protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)2.72627211
88behavioral response to nicotine (GO:0035095)2.72299185
89organ induction (GO:0001759)2.70339639
90positive regulation of uterine smooth muscle contraction (GO:0070474)2.69124003
91negative regulation of neural precursor cell proliferation (GO:2000178)2.64948511
92sphingolipid biosynthetic process (GO:0030148)2.64704618
93regulation of posttranscriptional gene silencing (GO:0060147)2.64457871
94regulation of gene silencing by miRNA (GO:0060964)2.64457871
95regulation of gene silencing by RNA (GO:0060966)2.64457871
96gene silencing by RNA (GO:0031047)2.64432130
97inflammatory response to antigenic stimulus (GO:0002437)2.62629617
98sphingosine metabolic process (GO:0006670)14.2851653
99diol metabolic process (GO:0034311)13.0612060
100sphingoid metabolic process (GO:0046519)12.1242243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.20731385
2AR_21572438_ChIP-Seq_LNCaP_Human3.93836488
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.36649439
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.95561058
5GBX2_23144817_ChIP-Seq_PC3_Human2.95462460
6ZNF274_21170338_ChIP-Seq_K562_Hela2.64368679
7* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.46692433
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.29778685
9VDR_22108803_ChIP-Seq_LS180_Human2.29002971
10P300_19829295_ChIP-Seq_ESCs_Human2.28351360
11EZH2_22144423_ChIP-Seq_EOC_Human2.21733686
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09810734
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.09626993
14ER_23166858_ChIP-Seq_MCF-7_Human2.06595027
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04831167
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01385843
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90827810
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90121551
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84702850
20STAT3_23295773_ChIP-Seq_U87_Human1.81844797
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.79122667
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78858887
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.78377202
24TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77571374
25POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.77571374
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75937956
27TCF4_23295773_ChIP-Seq_U87_Human1.74547932
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70109854
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69126913
30SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.69042904
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67780359
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.65571926
33NANOG_19829295_ChIP-Seq_ESCs_Human1.64324808
34SOX2_19829295_ChIP-Seq_ESCs_Human1.64324808
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.62251158
36SMAD4_21799915_ChIP-Seq_A2780_Human1.56880986
37AR_25329375_ChIP-Seq_VCAP_Human1.55026354
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.53371192
39HOXB7_26014856_ChIP-Seq_BT474_Human1.52037388
40TAF15_26573619_Chip-Seq_HEK293_Human1.49156453
41TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.48154832
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.46426098
43FUS_26573619_Chip-Seq_HEK293_Human1.44137427
44CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41350989
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41016185
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40025586
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34660937
48CBP_20019798_ChIP-Seq_JUKART_Human1.34660937
49FLI1_21867929_ChIP-Seq_TH2_Mouse1.33481578
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33226320
51SMAD4_21741376_ChIP-Seq_EPCs_Human1.32695707
52TP53_16413492_ChIP-PET_HCT116_Human1.30365513
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28706098
54TCF4_22108803_ChIP-Seq_LS180_Human1.28029496
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27371150
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.26036680
57OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25599545
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.25034466
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.22782948
60STAT3_18555785_ChIP-Seq_MESCs_Mouse1.22026853
61SMAD3_21741376_ChIP-Seq_HESCs_Human1.20460232
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19669627
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.19651822
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19591989
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17704016
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17535582
67AR_19668381_ChIP-Seq_PC3_Human1.16812196
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16808327
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16191734
70* PRDM14_20953172_ChIP-Seq_ESCs_Human1.14414590
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14374437
72TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14342710
73TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13358251
74CDX2_22108803_ChIP-Seq_LS180_Human1.12839295
75TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12508223
76BCAT_22108803_ChIP-Seq_LS180_Human1.12308964
77EWS_26573619_Chip-Seq_HEK293_Human1.11104136
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10469302
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.09382698
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09382698
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09293875
82NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08792181
83NCOR_22424771_ChIP-Seq_293T_Human1.08333580
84TP53_18474530_ChIP-ChIP_U2OS_Human1.07584238
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07254149
86REST_21632747_ChIP-Seq_MESCs_Mouse1.05446454
87* SMAD3_21741376_ChIP-Seq_ESCs_Human1.05415730
88EGR1_19032775_ChIP-ChIP_M12_Human1.04411730
89OCT4_20526341_ChIP-Seq_ESCs_Human1.04178116
90GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.04014881
91RUNX2_22187159_ChIP-Seq_PCA_Human1.02575500
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.01333231
93LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00866892
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00772903
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99438664
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.99237608
97STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97745012
98FOXH1_21741376_ChIP-Seq_ESCs_Human0.96383410
99RXR_22108803_ChIP-Seq_LS180_Human0.96156572
100STAT1_20625510_ChIP-Seq_HELA_Human0.94795736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis8.75845670
2MP0003136_yellow_coat_color7.44178973
3MP0005171_absent_coat_pigmentation6.84810319
4MP0002653_abnormal_ependyma_morphology5.58172551
5MP0003890_abnormal_embryonic-extraembry4.55493386
6MP0003045_fibrosis4.37149735
7MP0003646_muscle_fatigue4.15755034
8MP0000569_abnormal_digit_pigmentation3.96428098
9MP0003879_abnormal_hair_cell2.90636676
10MP0004381_abnormal_hair_follicle2.74841281
11MP0002138_abnormal_hepatobiliary_system2.42612827
12MP0003195_calcinosis2.21914106
13MP0002938_white_spotting2.16055399
14MP0005085_abnormal_gallbladder_physiolo2.12471933
15MP0005670_abnormal_white_adipose2.11815832
16MP0005075_abnormal_melanosome_morpholog2.01649814
17MP0004147_increased_porphyrin_level2.00447203
18MP0002168_other_aberrant_phenotype1.99284824
19MP0000749_muscle_degeneration1.62909098
20MP0005174_abnormal_tail_pigmentation1.50182520
21MP0002095_abnormal_skin_pigmentation1.47042508
22MP0010352_gastrointestinal_tract_polyps1.37963613
23MP0005365_abnormal_bile_salt1.34161516
24MP0004043_abnormal_pH_regulation1.31743178
25MP0002075_abnormal_coat/hair_pigmentati1.24119868
26MP0005395_other_phenotype1.23817309
27MP0000427_abnormal_hair_cycle1.20793655
28MP0002160_abnormal_reproductive_system1.20717736
29MP0001501_abnormal_sleep_pattern1.18403097
30MP0003705_abnormal_hypodermis_morpholog1.09442088
31MP0002735_abnormal_chemical_nociception1.09195086
32MP0003137_abnormal_impulse_conducting1.07537227
33MP0006054_spinal_hemorrhage0.99829357
34MP0003252_abnormal_bile_duct0.91882588
35MP0000015_abnormal_ear_pigmentation0.89370434
36MP0005551_abnormal_eye_electrophysiolog0.88244140
37MP0001186_pigmentation_phenotype0.85189419
38MP0009046_muscle_twitch0.84399548
39MP0004233_abnormal_muscle_weight0.83676225
40MP0002272_abnormal_nervous_system0.83262356
41MP0001984_abnormal_olfaction0.83136193
42MP0002876_abnormal_thyroid_physiology0.82612564
43MP0001486_abnormal_startle_reflex0.82495623
44MP0001324_abnormal_eye_pigmentation0.80818867
45MP0009745_abnormal_behavioral_response0.77060978
46MP0002928_abnormal_bile_duct0.72112944
47MP0005646_abnormal_pituitary_gland0.69247499
48MP0003950_abnormal_plasma_membrane0.67550002
49MP0002269_muscular_atrophy0.66103283
50MP0003937_abnormal_limbs/digits/tail_de0.65180845
51MP0008770_decreased_survivor_rate0.64460338
52MP0008872_abnormal_physiological_respon0.64186167
53MP0008057_abnormal_DNA_replication0.63551859
54MP0004142_abnormal_muscle_tone0.62877531
55MP0003878_abnormal_ear_physiology0.62180569
56MP0005377_hearing/vestibular/ear_phenot0.62180569
57MP0005330_cardiomyopathy0.61303825
58MP0002102_abnormal_ear_morphology0.61048537
59MP0005389_reproductive_system_phenotype0.60965900
60MP0001970_abnormal_pain_threshold0.60490093
61MP0002254_reproductive_system_inflammat0.60033919
62MP0004130_abnormal_muscle_cell0.60029311
63MP0001968_abnormal_touch/_nociception0.58358274
64MP0000383_abnormal_hair_follicle0.58055921
65MP0002751_abnormal_autonomic_nervous0.56304458
66MP0002064_seizures0.55440214
67MP0002572_abnormal_emotion/affect_behav0.53994303
68MP0002332_abnormal_exercise_endurance0.51492329
69MP0001986_abnormal_taste_sensitivity0.50971972
70MP0002229_neurodegeneration0.50294521
71MP0008569_lethality_at_weaning0.49575816
72MP0000534_abnormal_ureter_morphology0.49562737
73MP0005253_abnormal_eye_physiology0.49202061
74MP0002733_abnormal_thermal_nociception0.47525824
75MP0000372_irregular_coat_pigmentation0.45563019
76MP0005319_abnormal_enzyme/_coenzyme0.45085669
77MP0001661_extended_life_span0.43740826
78MP0005410_abnormal_fertilization0.43407118
79MP0009115_abnormal_fat_cell0.42915681
80MP0006072_abnormal_retinal_apoptosis0.42771525
81MP0006276_abnormal_autonomic_nervous0.41813353
82MP0002277_abnormal_respiratory_mucosa0.41233817
83MP0005266_abnormal_metabolism0.41052907
84MP0008875_abnormal_xenobiotic_pharmacok0.40954165
85MP0009764_decreased_sensitivity_to0.39336102
86MP0003632_abnormal_nervous_system0.39167561
87MP0000470_abnormal_stomach_morphology0.38095653
88MP0000026_abnormal_inner_ear0.37092394
89MP0005448_abnormal_energy_balance0.36148020
90MP0002971_abnormal_brown_adipose0.36094051
91MP0003635_abnormal_synaptic_transmissio0.34115105
92MP0005076_abnormal_cell_differentiation0.33937262
93MP0010307_abnormal_tumor_latency0.33740193
94MP0002396_abnormal_hematopoietic_system0.32671730
95MP0005220_abnormal_exocrine_pancreas0.32441944
96MP0008877_abnormal_DNA_methylation0.32085665
97MP0001485_abnormal_pinna_reflex0.31626078
98MP0002557_abnormal_social/conspecific_i0.30503983
99MP0003698_abnormal_male_reproductive0.30444153
100MP0000778_abnormal_nervous_system0.30275739

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)8.51157426
2Focal motor seizures (HP:0011153)8.23455976
3Acanthocytosis (HP:0001927)6.24068187
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.92355228
5Parakeratosis (HP:0001036)5.70301797
6Pancreatic cysts (HP:0001737)4.72675763
7Dialeptic seizures (HP:0011146)4.71832393
8Aplastic anemia (HP:0001915)4.60650028
9Colon cancer (HP:0003003)4.10301306
10Aplasia/Hypoplasia of the uvula (HP:0010293)4.08745315
11Focal seizures (HP:0007359)3.85310744
12Hematochezia (HP:0002573)3.77749192
13Proximal amyotrophy (HP:0007126)3.68348789
14Rectal prolapse (HP:0002035)3.59503738
15Abnormality of the renal cortex (HP:0011035)3.50921633
16Erythroderma (HP:0001019)3.20808644
17Difficulty walking (HP:0002355)3.19379642
18Congenital ichthyosiform erythroderma (HP:0007431)3.19232089
19Vertebral arch anomaly (HP:0008438)3.14191240
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.09836801
21Abnormality of the renal medulla (HP:0100957)3.03660122
22Pendular nystagmus (HP:0012043)3.01472616
23Spontaneous hematomas (HP:0007420)2.95829121
24Progressive inability to walk (HP:0002505)2.95483334
25Potter facies (HP:0002009)2.92119271
26Facial shape deformation (HP:0011334)2.92119271
27Enlarged kidneys (HP:0000105)2.92014340
28Nephronophthisis (HP:0000090)2.78536024
29Decreased circulating renin level (HP:0003351)2.76951567
30Scapular winging (HP:0003691)2.75767426
31Poikilocytosis (HP:0004447)2.74158339
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68339507
33Ulnar claw (HP:0001178)2.67944219
34Hypoplastic iliac wings (HP:0002866)2.64450136
35Cystic liver disease (HP:0006706)2.63945417
36Pancreatic fibrosis (HP:0100732)2.63562802
37Cerebellar dysplasia (HP:0007033)2.57618555
38Congenital stationary night blindness (HP:0007642)2.56925636
39Tubular atrophy (HP:0000092)2.54396092
40Bilateral sensorineural hearing impairment (HP:0008619)2.50405035
41Conjunctival telangiectasia (HP:0000524)2.44915357
42Radial bowing (HP:0002986)2.39779857
43Overlapping toe (HP:0001845)2.38946745
44Inability to walk (HP:0002540)2.38806001
45Chromsome breakage (HP:0040012)2.38475548
46Broad ribs (HP:0000885)2.34986305
47Type II lissencephaly (HP:0007260)2.34873250
48Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.33848039
49Portal hypertension (HP:0001409)2.33242951
50Gaze-evoked nystagmus (HP:0000640)2.33073024
51Synostosis of carpal bones (HP:0005048)2.32769127
52Esophageal varix (HP:0002040)2.32630267
53Abnormality of macular pigmentation (HP:0008002)2.32628582
54Chronic hepatic failure (HP:0100626)2.30874308
55Severe visual impairment (HP:0001141)2.30584686
56Genetic anticipation (HP:0003743)2.29857726
57Abnormality of the hepatic vasculature (HP:0006707)2.17809256
58Clumsiness (HP:0002312)2.17498177
59Stomach cancer (HP:0012126)2.16206759
60Albinism (HP:0001022)2.15300429
61Hypokalemia (HP:0002900)2.13030087
62Increased neuronal autofluorescent lipopigment (HP:0002074)2.12579161
63Hypoalbuminemia (HP:0003073)2.12456790
64Abnormal albumin level (HP:0012116)2.12456790
65True hermaphroditism (HP:0010459)2.08688666
66Abnormality of monocarboxylic acid metabolism (HP:0010996)2.05382944
67Tubulointerstitial fibrosis (HP:0005576)2.03836282
68Ulnar bowing (HP:0003031)2.03630653
69Abnormality of potassium homeostasis (HP:0011042)2.00191917
70Retinitis pigmentosa (HP:0000510)1.98675646
71Type I transferrin isoform profile (HP:0003642)1.98629846
72Congenital hepatic fibrosis (HP:0002612)1.97579109
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.92355902
74IgM deficiency (HP:0002850)1.92080760
75Autoimmune hemolytic anemia (HP:0001890)1.90240389
76Neoplasm of the adrenal cortex (HP:0100641)1.89940269
77Hyperventilation (HP:0002883)1.89925414
78Abnormality of the vasculature of the conjunctiva (HP:0008054)1.87684984
79Tarsal synostosis (HP:0008368)1.86627587
80Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86540211
81Progressive cerebellar ataxia (HP:0002073)1.85582526
82Absence seizures (HP:0002121)1.83364806
83Polydipsia (HP:0001959)1.83254089
84Abnormal drinking behavior (HP:0030082)1.83254089
85Abnormality of the vocal cords (HP:0008777)1.79637584
86Neoplasm of the small intestine (HP:0100833)1.78881326
87Birth length less than 3rd percentile (HP:0003561)1.78811601
88Opisthotonus (HP:0002179)1.76831594
89Chronic diarrhea (HP:0002028)1.76320962
90Dehydration (HP:0001944)1.74460477
91Synostosis involving bones of the lower limbs (HP:0009138)1.74228162
92Synostosis involving bones of the feet (HP:0009140)1.74228162
93Gangrene (HP:0100758)1.72652920
94Molar tooth sign on MRI (HP:0002419)1.70255485
95Abnormality of midbrain morphology (HP:0002418)1.70255485
96Macular degeneration (HP:0000608)1.67040881
97Hypoplasia of the pons (HP:0012110)1.65250015
98Abnormality of the wing of the ilium (HP:0011867)1.65178820
99Hyperkalemia (HP:0002153)1.65049080
100Abnormality of the shoulder girdle musculature (HP:0001435)1.64403373

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L6.87534323
2LATS25.82353408
3FRK4.38998577
4ACVR1B3.38696043
5ZAK3.02848948
6PRKD32.85819013
7BMPR1B2.69119649
8STK382.53713733
9NLK2.46392153
10STK32.15103130
11LATS110.0416039
12MELK1.95024438
13MAP2K21.83974517
14TAF11.12949429
15NEK21.12288361
16TGFBR11.05522578
17PRKAA21.04764910
18PIK3CG1.04585745
19ADRBK21.03878216
20MAP3K21.00854964
21PINK10.89477779
22EIF2AK30.89111267
23CSNK1A1L0.81930521
24ADRBK10.75168116
25PDPK10.74599286
26GRK70.73715733
27TAOK30.66972810
28DAPK20.66379113
29KSR20.59247950
30WNK30.59029027
31GRK10.55651965
32MKNK20.55243595
33WNK40.54750564
34INSRR0.51912072
35PRKD10.50727869
36OXSR10.50170415
37STK390.46812846
38STK110.43552873
39TTK0.42484078
40TNK20.42249186
41AKT30.41902702
42TGFBR20.41628330
43MAP2K10.41046127
44NEK90.40942831
45NUAK10.39173648
46MAPK130.38502936
47IRAK30.37931001
48GRK50.29988902
49CHEK20.29685301
50PIM10.28685000
51FER0.28639882
52CSNK1D0.27748237
53NME10.27592617
54NTRK30.27461019
55PRKCE0.26204108
56PLK10.25889959
57CASK0.23627975
58MAP4K20.23532462
59TEC0.20750184
60PRKCI0.19984241
61PLK20.16650150
62TXK0.14619046
63ABL10.14216336
64TLK10.12993801
65PRKCG0.12906784
66STK100.12741602
67MAPK30.12175836
68CDK30.11902597
69PTK2B0.11164685
70PRKACA0.10409432
71BRSK20.09762419
72MAP3K40.09701352
73TNIK0.09461725
74CAMK2A0.09391919
75EIF2AK20.09336616
76TRPM70.08762098
77ATR0.08574712
78MAP3K70.08478670
79STK240.08394131
80MAPK10.07406880
81MOS0.07072205
82PLK30.06944513
83PRKACB0.06560887
84MKNK10.05900399
85FGFR20.05835888
86MAPK80.04903678
87CSNK1A10.04823963
88ATM0.04365646
89ITK0.03370224
90PRKCH0.03080066
91MARK10.02342337
92PAK30.01487798
93GSK3B0.01214289
94PIK3CA0.01049524
95IRAK1-0.0263784
96OBSCN-0.0245521
97PRKCZ-0.0229706
98AKT2-0.0147229
99MARK3-0.0104524
100AKT1-0.0032549

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004006.77695946
2Phototransduction_Homo sapiens_hsa047444.61686670
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.69113025
4Sphingolipid metabolism_Homo sapiens_hsa006003.58861638
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.41730230
6Nicotine addiction_Homo sapiens_hsa050333.19922089
7Dorso-ventral axis formation_Homo sapiens_hsa043202.79486845
8Taste transduction_Homo sapiens_hsa047422.42493567
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.06808919
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.05856023
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.94607366
12Morphine addiction_Homo sapiens_hsa050321.94188617
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.91213885
14N-Glycan biosynthesis_Homo sapiens_hsa005101.68914701
15Tryptophan metabolism_Homo sapiens_hsa003801.67994378
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59907155
17GABAergic synapse_Homo sapiens_hsa047271.49142017
18Butanoate metabolism_Homo sapiens_hsa006501.43389234
19Phenylalanine metabolism_Homo sapiens_hsa003601.42520596
20Histidine metabolism_Homo sapiens_hsa003401.42208961
21Nitrogen metabolism_Homo sapiens_hsa009101.40408247
22ABC transporters_Homo sapiens_hsa020101.39603093
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29509448
24Calcium signaling pathway_Homo sapiens_hsa040201.28212976
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26424965
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23471015
27One carbon pool by folate_Homo sapiens_hsa006701.23230073
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19472652
29Glutamatergic synapse_Homo sapiens_hsa047241.08285856
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05796719
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05342803
32Basal transcription factors_Homo sapiens_hsa030221.01678265
33Vitamin digestion and absorption_Homo sapiens_hsa049771.01480204
34Homologous recombination_Homo sapiens_hsa034400.99715123
35Serotonergic synapse_Homo sapiens_hsa047260.98119754
36Glycerolipid metabolism_Homo sapiens_hsa005610.91882433
37Steroid hormone biosynthesis_Homo sapiens_hsa001400.91586017
38Lysine degradation_Homo sapiens_hsa003100.91415120
39Ovarian steroidogenesis_Homo sapiens_hsa049130.91179763
40Fanconi anemia pathway_Homo sapiens_hsa034600.90151884
41Selenocompound metabolism_Homo sapiens_hsa004500.83903811
42Sphingolipid signaling pathway_Homo sapiens_hsa040710.80700623
43Linoleic acid metabolism_Homo sapiens_hsa005910.79246705
44Dilated cardiomyopathy_Homo sapiens_hsa054140.79178165
45Olfactory transduction_Homo sapiens_hsa047400.73359699
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.73018157
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72863843
48TGF-beta signaling pathway_Homo sapiens_hsa043500.71543870
49beta-Alanine metabolism_Homo sapiens_hsa004100.70249843
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68520701
51Bile secretion_Homo sapiens_hsa049760.67365688
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66293001
53cAMP signaling pathway_Homo sapiens_hsa040240.65190033
54Tyrosine metabolism_Homo sapiens_hsa003500.62831794
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61458972
56Circadian entrainment_Homo sapiens_hsa047130.58771652
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55199643
58VEGF signaling pathway_Homo sapiens_hsa043700.52904143
59Salivary secretion_Homo sapiens_hsa049700.52840622
60Hippo signaling pathway_Homo sapiens_hsa043900.52532793
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51849871
62Insulin secretion_Homo sapiens_hsa049110.50267511
63Retinol metabolism_Homo sapiens_hsa008300.50248557
64Chemical carcinogenesis_Homo sapiens_hsa052040.47865832
65Fatty acid degradation_Homo sapiens_hsa000710.46301565
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45165353
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44598422
68Viral myocarditis_Homo sapiens_hsa054160.40598917
69Colorectal cancer_Homo sapiens_hsa052100.39814520
70Collecting duct acid secretion_Homo sapiens_hsa049660.39548091
71Adherens junction_Homo sapiens_hsa045200.35788252
72ECM-receptor interaction_Homo sapiens_hsa045120.35457325
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.34982431
74Fatty acid biosynthesis_Homo sapiens_hsa000610.34324852
75Type II diabetes mellitus_Homo sapiens_hsa049300.33979657
76Ether lipid metabolism_Homo sapiens_hsa005650.33440407
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33181356
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33044195
79Cholinergic synapse_Homo sapiens_hsa047250.32564287
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31433033
81Gastric acid secretion_Homo sapiens_hsa049710.31319559
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.31079756
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30755267
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30234432
85Propanoate metabolism_Homo sapiens_hsa006400.28750086
86Basal cell carcinoma_Homo sapiens_hsa052170.27527761
87Caffeine metabolism_Homo sapiens_hsa002320.25056559
88Peroxisome_Homo sapiens_hsa041460.24212410
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24124775
90Thyroid hormone synthesis_Homo sapiens_hsa049180.23483812
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23114252
92Long-term depression_Homo sapiens_hsa047300.22252819
93Cell cycle_Homo sapiens_hsa041100.20323820
94Oocyte meiosis_Homo sapiens_hsa041140.19607015
95Arachidonic acid metabolism_Homo sapiens_hsa005900.19295954
96Non-homologous end-joining_Homo sapiens_hsa034500.19162872
97Metabolic pathways_Homo sapiens_hsa011000.19098294
98Pyruvate metabolism_Homo sapiens_hsa006200.18393270
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18061124
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17169247

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