ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neural tube formation (GO:0001841)	5.09360344
2	preassembly of GPI anchor in ER membrane (GO:0016254)	4.53065628
3	DNA double-strand break processing (GO:0000729)	4.15649406
4	L-fucose metabolic process (GO:0042354)	4.14807596
5	L-fucose catabolic process (GO:0042355)	4.14807596
6	fucose catabolic process (GO:0019317)	4.14807596
7	mannosylation (GO:0097502)	4.00654476
8	behavioral response to nicotine (GO:0035095)	3.94500089
9	GPI anchor metabolic process (GO:0006505)	3.81623807
10	kynurenine metabolic process (GO:0070189)	3.80337871
11	piRNA metabolic process (GO:0034587)	3.76307196
12	indolalkylamine metabolic process (GO:0006586)	3.71923090
13	pyrimidine dimer repair (GO:0006290)	3.58319688
14	DNA deamination (GO:0045006)	3.58237620
15	peptidyl-histidine modification (GO:0018202)	3.51599537
16	photoreceptor cell maintenance (GO:0045494)	3.43904893
17	prenylation (GO:0097354)	3.42387191
18	protein prenylation (GO:0018342)	3.42387191
19	rRNA catabolic process (GO:0016075)	3.41758030
20	indole-containing compound catabolic process (GO:0042436)	3.38126557
21	indolalkylamine catabolic process (GO:0046218)	3.38126557
22	tryptophan catabolic process (GO:0006569)	3.38126557
23	detection of light stimulus involved in visual perception (GO:0050908)	3.36875047
24	detection of light stimulus involved in sensory perception (GO:0050962)	3.36875047
25	DNA methylation involved in gamete generation (GO:0043046)	3.32840018
26	regulation of memory T cell differentiation (GO:0043380)	3.29830320
27	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.29701972
28	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.29587890
29	regulation of meiosis I (GO:0060631)	3.28988553
30	negative regulation of telomere maintenance (GO:0032205)	3.25170901
31	adaptation of signaling pathway (GO:0023058)	3.22717563
32	DNA demethylation (GO:0080111)	3.19755694
33	tryptophan metabolic process (GO:0006568)	3.19106606
34	GPI anchor biosynthetic process (GO:0006506)	3.17901652
35	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.16940571
36	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.14794151
37	platelet dense granule organization (GO:0060155)	3.06774742
38	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.06378316
39	cilium morphogenesis (GO:0060271)	3.05650227
40	pyrimidine nucleobase catabolic process (GO:0006208)	3.02721426
41	olfactory bulb development (GO:0021772)	3.02364477
42	nonmotile primary cilium assembly (GO:0035058)	3.02147496
43	C-terminal protein lipidation (GO:0006501)	2.99338252
44	protein K11-linked deubiquitination (GO:0035871)	2.98962014
45	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.98185367
46	regulation of mitotic spindle checkpoint (GO:1903504)	2.98185367
47	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.96233804
48	male meiosis (GO:0007140)	2.94374828
49	C-terminal protein amino acid modification (GO:0018410)	2.94051339
50	iron-sulfur cluster assembly (GO:0016226)	2.91873251
51	metallo-sulfur cluster assembly (GO:0031163)	2.91873251
52	ubiquinone biosynthetic process (GO:0006744)	2.91151251
53	epithelial cilium movement (GO:0003351)	2.90622221
54	ubiquinone metabolic process (GO:0006743)	2.85257053
55	negative regulation of multicellular organism growth (GO:0040015)	2.84675155
56	anterograde synaptic vesicle transport (GO:0048490)	2.80011627
57	reciprocal meiotic recombination (GO:0007131)	2.77089583
58	reciprocal DNA recombination (GO:0035825)	2.77089583
59	regulation of cilium movement (GO:0003352)	2.76929365
60	positive regulation of mitochondrial fission (GO:0090141)	2.76383564
61	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.76271847
62	cilium movement (GO:0003341)	2.73275012
63	DNA integration (GO:0015074)	2.72809825
64	cilium organization (GO:0044782)	2.71854942
65	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.71569403
66	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.71569403
67	water-soluble vitamin biosynthetic process (GO:0042364)	2.70942788
68	intraciliary transport (GO:0042073)	2.68586044
69	oxidative demethylation (GO:0070989)	2.68053184
70	regulation of MHC class I biosynthetic process (GO:0045343)	2.66917312
71	axoneme assembly (GO:0035082)	2.66699389
72	negative regulation of mast cell activation (GO:0033004)	2.64138621
73	replication fork processing (GO:0031297)	2.63546572
74	S-adenosylmethionine metabolic process (GO:0046500)	2.62799105
75	centriole replication (GO:0007099)	2.61192814
76	response to lipoprotein particle (GO:0055094)	2.60763771
77	multicellular organism reproduction (GO:0032504)	2.60275592
78	seminiferous tubule development (GO:0072520)	2.59635158
79	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.58933179
80	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.58933179
81	L-methionine salvage (GO:0071267)	2.58433285
82	L-methionine biosynthetic process (GO:0071265)	2.58433285
83	amino acid salvage (GO:0043102)	2.58433285
84	cilium assembly (GO:0042384)	2.58402247
85	nucleobase catabolic process (GO:0046113)	2.57247304
86	regulation of hexokinase activity (GO:1903299)	2.56225613
87	regulation of glucokinase activity (GO:0033131)	2.56225613
88	gamma-aminobutyric acid transport (GO:0015812)	2.55467704
89	DNA dealkylation (GO:0035510)	2.55262853
90	indole-containing compound metabolic process (GO:0042430)	2.54028436
91	male meiosis I (GO:0007141)	2.53474894
92	protein-cofactor linkage (GO:0018065)	2.52815096
93	glycolipid biosynthetic process (GO:0009247)	2.52496132
94	positive regulation of T cell cytokine production (GO:0002726)	2.51758588
95	nucleotide transmembrane transport (GO:1901679)	2.51717057
96	embryonic epithelial tube formation (GO:0001838)	2.49992873
97	establishment of protein localization to Golgi (GO:0072600)	2.48260680
98	recombinational repair (GO:0000725)	2.45685324
99	double-strand break repair via homologous recombination (GO:0000724)	2.44282035
100	quinone biosynthetic process (GO:1901663)	2.43845680

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.88952673
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.14044658
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.93278674
4	VDR_22108803_ChIP-Seq_LS180_Human	2.90449230
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.85377383
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.79617261
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.73412586
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.72011511
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.62257705
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.61310933
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.44658318
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.40506131
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.28568097
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.22666179
15	EWS_26573619_Chip-Seq_HEK293_Human	2.20469327
16	P300_19829295_ChIP-Seq_ESCs_Human	2.20046778
17	ER_23166858_ChIP-Seq_MCF-7_Human	2.19083935
18	FUS_26573619_Chip-Seq_HEK293_Human	2.16933431
19	EZH2_22144423_ChIP-Seq_EOC_Human	2.14817783
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.02313198
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.99862198
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.94452664
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.87779990
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87236444
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.82478886
26	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.77473624
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.75415087
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.69524392
29	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.63955116
30	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.63026595
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.62785361
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.58115126
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.57004546
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.57004546
35	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.54967189
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.54660188
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54043100
38	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.53740509
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.52500803
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52335141
41	STAT3_23295773_ChIP-Seq_U87_Human	1.50281993
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50010938
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.49963933
44	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.49256230
45	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44426672
46	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.44054585
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.42339900
48	VDR_23849224_ChIP-Seq_CD4+_Human	1.40904979
49	AR_25329375_ChIP-Seq_VCAP_Human	1.39931567
50	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.39036591
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37330815
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37222597
53	TCF4_23295773_ChIP-Seq_U87_Human	1.36065971
54	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.34732718
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.31893502
56	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29194786
57	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.28370839
58	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.27908480
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26951273
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26282452
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.26080420
62	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.25441782
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24616230
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23901472
65	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.23337470
66	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23103958
67	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21675129
68	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.21434324
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21335661
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17920613
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.17920613
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14834913
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14834913
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13545274
75	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13506877
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13506877
77	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13302716
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11172776
79	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.10500531
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10267558
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08554701
82	CDX2_22108803_ChIP-Seq_LS180_Human	1.08093489
83	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.07156778
84	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.06606280
85	* NCOR_22424771_ChIP-Seq_293T_Human	1.06227841
86	* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05170401
87	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05003227
88	AR_20517297_ChIP-Seq_VCAP_Human	1.04857597
89	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.03828623
90	AR_21572438_ChIP-Seq_LNCaP_Human	1.03619175
91	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03419884
92	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.01613960
93	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01288288
94	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.00677464
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99885021
96	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.99619827
97	P300_18555785_Chip-Seq_ESCs_Mouse	0.96587108
98	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.96405846
99	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.96307840
100	GATA3_26560356_Chip-Seq_TH2_Human	0.95850737

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.54388638
2	MP0000569_abnormal_digit_pigmentation	3.29029840
3	MP0008877_abnormal_DNA_methylation	3.16798424
4	MP0003880_abnormal_central_pattern	2.78146979
5	MP0003252_abnormal_bile_duct	2.41640385
6	MP0002736_abnormal_nociception_after	2.34963408
7	MP0006292_abnormal_olfactory_placode	2.32974458
8	MP0002837_dystrophic_cardiac_calcinosis	2.25651360
9	MP0001968_abnormal_touch/_nociception	2.20552433
10	MP0003011_delayed_dark_adaptation	2.20013460
11	MP0003724_increased_susceptibility_to	2.18917760
12	MP0006072_abnormal_retinal_apoptosis	2.13257764
13	MP0005551_abnormal_eye_electrophysiolog	2.04984478
14	MP0004147_increased_porphyrin_level	1.99764753
15	MP0001986_abnormal_taste_sensitivity	1.99332116
16	MP0005253_abnormal_eye_physiology	1.94062352
17	MP0003787_abnormal_imprinting	1.87926472
18	MP0003195_calcinosis	1.85922273
19	MP0000427_abnormal_hair_cycle	1.74960784
20	MP0006276_abnormal_autonomic_nervous	1.74112647
21	MP0002653_abnormal_ependyma_morphology	1.64039253
22	MP0005645_abnormal_hypothalamus_physiol	1.60334854
23	MP0001984_abnormal_olfaction	1.58632813
24	MP0008789_abnormal_olfactory_epithelium	1.58513823
25	MP0002138_abnormal_hepatobiliary_system	1.56571093
26	MP0002928_abnormal_bile_duct	1.54922077
27	MP0008995_early_reproductive_senescence	1.51950827
28	MP0004133_heterotaxia	1.50567073
29	MP0005499_abnormal_olfactory_system	1.47250009
30	MP0005394_taste/olfaction_phenotype	1.47250009
31	MP0004142_abnormal_muscle_tone	1.45299067
32	MP0008058_abnormal_DNA_repair	1.45065573
33	MP0001501_abnormal_sleep_pattern	1.44015880
34	MP0001486_abnormal_startle_reflex	1.42626015
35	MP0005646_abnormal_pituitary_gland	1.42331574
36	MP0005085_abnormal_gallbladder_physiolo	1.41270085
37	MP0002638_abnormal_pupillary_reflex	1.38016216
38	MP0000631_abnormal_neuroendocrine_gland	1.37387690
39	MP0008872_abnormal_physiological_respon	1.37374066
40	MP0004043_abnormal_pH_regulation	1.36690233
41	MP0001529_abnormal_vocalization	1.36207529
42	MP0003136_yellow_coat_color	1.35213841
43	MP0003646_muscle_fatigue	1.33379514
44	MP0005075_abnormal_melanosome_morpholog	1.32825039
45	MP0000383_abnormal_hair_follicle	1.30881712
46	MP0000372_irregular_coat_pigmentation	1.29800191
47	MP0002234_abnormal_pharynx_morphology	1.28970065
48	MP0003718_maternal_effect	1.26642276
49	MP0001485_abnormal_pinna_reflex	1.24312682
50	MP0009745_abnormal_behavioral_response	1.21213428
51	MP0001293_anophthalmia	1.20461596
52	MP0009046_muscle_twitch	1.15954040
53	MP0005174_abnormal_tail_pigmentation	1.15924911
54	MP0003121_genomic_imprinting	1.15820201
55	MP0005389_reproductive_system_phenotype	1.14783555
56	MP0008875_abnormal_xenobiotic_pharmacok	1.13729441
57	MP0000516_abnormal_urinary_system	1.12730415
58	MP0005367_renal/urinary_system_phenotyp	1.12730415
59	MP0000465_gastrointestinal_hemorrhage	1.12162462
60	MP0005084_abnormal_gallbladder_morpholo	1.12072410
61	MP0006035_abnormal_mitochondrial_morpho	1.09662537
62	MP0002751_abnormal_autonomic_nervous	1.08383582
63	MP0010386_abnormal_urinary_bladder	1.08057287
64	MP0002095_abnormal_skin_pigmentation	1.07569895
65	MP0002160_abnormal_reproductive_system	1.06682479
66	MP0003786_premature_aging	1.05485664
67	MP0001324_abnormal_eye_pigmentation	1.05360617
68	MP0003122_maternal_imprinting	1.03906403
69	MP0001929_abnormal_gametogenesis	1.00385576
70	MP0002067_abnormal_sensory_capabilities	0.98345575
71	MP0003698_abnormal_male_reproductive	0.98277765
72	MP0002272_abnormal_nervous_system	0.97938108
73	MP0001188_hyperpigmentation	0.97208038
74	MP0000647_abnormal_sebaceous_gland	0.97020828
75	MP0005386_behavior/neurological_phenoty	0.94734149
76	MP0004924_abnormal_behavior	0.94734149
77	MP0000778_abnormal_nervous_system	0.92159813
78	MP0002733_abnormal_thermal_nociception	0.92065979
79	MP0004145_abnormal_muscle_electrophysio	0.91910616
80	MP0003137_abnormal_impulse_conducting	0.90926393
81	MP0000653_abnormal_sex_gland	0.89813713
82	MP0005410_abnormal_fertilization	0.89788940
83	MP0005195_abnormal_posterior_eye	0.87890709
84	MP0001919_abnormal_reproductive_system	0.87290108
85	MP0001764_abnormal_homeostasis	0.85503183
86	MP0002938_white_spotting	0.84476417
87	MP0005187_abnormal_penis_morphology	0.83356822
88	MP0005391_vision/eye_phenotype	0.82665749
89	MP0004885_abnormal_endolymph	0.82441612
90	MP0001970_abnormal_pain_threshold	0.81403635
91	MP0004215_abnormal_myocardial_fiber	0.80087171
92	MP0002210_abnormal_sex_determination	0.76311107
93	MP0001145_abnormal_male_reproductive	0.75160722
94	MP0003119_abnormal_digestive_system	0.75018279
95	MP0004742_abnormal_vestibular_system	0.74266530
96	MP0000015_abnormal_ear_pigmentation	0.73943046
97	MP0002572_abnormal_emotion/affect_behav	0.73888902
98	MP0003890_abnormal_embryonic-extraembry	0.73472508
99	MP0001963_abnormal_hearing_physiology	0.73405593
100	MP0005248_abnormal_Harderian_gland	0.73260768

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.10212779
2	Pancreatic fibrosis (HP:0100732)	3.96628252
3	True hermaphroditism (HP:0010459)	3.77422620
4	Chronic hepatic failure (HP:0100626)	3.69459783
5	Molar tooth sign on MRI (HP:0002419)	3.62866442
6	Abnormality of midbrain morphology (HP:0002418)	3.62866442
7	Type II lissencephaly (HP:0007260)	3.54771517
8	Medial flaring of the eyebrow (HP:0010747)	3.47507421
9	Nephronophthisis (HP:0000090)	3.44088744
10	Genetic anticipation (HP:0003743)	3.23651601
11	Hyperventilation (HP:0002883)	3.21310809
12	Abnormality of the renal medulla (HP:0100957)	2.88827087
13	Abnormality of the renal cortex (HP:0011035)	2.88768733
14	Methylmalonic acidemia (HP:0002912)	2.88027039
15	Inability to walk (HP:0002540)	2.87847741
16	Congenital primary aphakia (HP:0007707)	2.85801290
17	Gait imbalance (HP:0002141)	2.84538436
18	Retinal dysplasia (HP:0007973)	2.80092098
19	Absent speech (HP:0001344)	2.72252161
20	Attenuation of retinal blood vessels (HP:0007843)	2.69969574
21	Nephrogenic diabetes insipidus (HP:0009806)	2.69572867
22	Stomach cancer (HP:0012126)	2.69219796
23	Gaze-evoked nystagmus (HP:0000640)	2.61956257
24	Bile duct proliferation (HP:0001408)	2.61333885
25	Abnormal biliary tract physiology (HP:0012439)	2.61333885
26	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.59226343
27	Progressive cerebellar ataxia (HP:0002073)	2.51988292
28	Congenital hepatic fibrosis (HP:0002612)	2.45473395
29	Progressive inability to walk (HP:0002505)	2.44235964
30	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.42292691
31	Cystic liver disease (HP:0006706)	2.41632370
32	Abolished electroretinogram (ERG) (HP:0000550)	2.38374127
33	Genital tract atresia (HP:0001827)	2.36663563
34	Stomatitis (HP:0010280)	2.36007380
35	Lissencephaly (HP:0001339)	2.30581444
36	Methylmalonic aciduria (HP:0012120)	2.29781939
37	Renal cortical cysts (HP:0000803)	2.29533046
38	Vaginal atresia (HP:0000148)	2.25561505
39	Cerebellar dysplasia (HP:0007033)	2.22502035
40	Hyperglycinemia (HP:0002154)	2.21355661
41	Colon cancer (HP:0003003)	2.14815934
42	Lipid accumulation in hepatocytes (HP:0006561)	2.13144630
43	Congenital stationary night blindness (HP:0007642)	2.12244022
44	Hyperglycinuria (HP:0003108)	2.10165872
45	Pendular nystagmus (HP:0012043)	2.09882351
46	Tubular atrophy (HP:0000092)	2.04944256
47	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.04726454
48	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.04726454
49	Prostate neoplasm (HP:0100787)	2.02041081
50	Sclerocornea (HP:0000647)	2.02025415
51	Postaxial hand polydactyly (HP:0001162)	2.02024450
52	Fair hair (HP:0002286)	2.01809201
53	Postaxial foot polydactyly (HP:0001830)	2.01798410
54	Decreased central vision (HP:0007663)	2.01320661
55	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.00574418
56	Hypoplasia of the fovea (HP:0007750)	2.00574418
57	Abnormal drinking behavior (HP:0030082)	1.99746353
58	Polydipsia (HP:0001959)	1.99746353
59	Anencephaly (HP:0002323)	1.99144372
60	Short tibia (HP:0005736)	1.99141376
61	Abnormality of glycine metabolism (HP:0010895)	1.98972798
62	Abnormality of serine family amino acid metabolism (HP:0010894)	1.98972798
63	Poor coordination (HP:0002370)	1.97296537
64	Abnormality of the labia minora (HP:0012880)	1.94410855
65	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.90045213
66	Protruding tongue (HP:0010808)	1.89164743
67	Retinitis pigmentosa (HP:0000510)	1.88964104
68	Abnormality of vitamin B metabolism (HP:0004340)	1.88445271
69	Abnormality of the fovea (HP:0000493)	1.87307544
70	Occipital encephalocele (HP:0002085)	1.86650927
71	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.86623371
72	Abnormal protein N-linked glycosylation (HP:0012347)	1.86623371
73	Abnormal protein glycosylation (HP:0012346)	1.86623371
74	Abnormal glycosylation (HP:0012345)	1.86623371
75	Bilateral microphthalmos (HP:0007633)	1.85414233
76	Hemiparesis (HP:0001269)	1.85244250
77	Broad-based gait (HP:0002136)	1.85215792
78	Abnormality of chromosome stability (HP:0003220)	1.81087048
79	Bony spicule pigmentary retinopathy (HP:0007737)	1.78513275
80	Pachygyria (HP:0001302)	1.78006370
81	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.77125718
82	Abnormality of macular pigmentation (HP:0008002)	1.75695955
83	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.74830087
84	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.74282786
85	Male pseudohermaphroditism (HP:0000037)	1.74218781
86	Keratoconus (HP:0000563)	1.74127023
87	Increased corneal curvature (HP:0100692)	1.74127023
88	Dandy-Walker malformation (HP:0001305)	1.73772688
89	Astigmatism (HP:0000483)	1.72510204
90	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.71709042
91	Abnormality of alanine metabolism (HP:0010916)	1.71709042
92	Hyperalaninemia (HP:0003348)	1.71709042
93	Dialeptic seizures (HP:0011146)	1.71398062
94	Specific learning disability (HP:0001328)	1.71298392
95	Abnormal rod and cone electroretinograms (HP:0008323)	1.71106959
96	Oculomotor apraxia (HP:0000657)	1.70841984
97	Aganglionic megacolon (HP:0002251)	1.70195297
98	Abnormal ciliary motility (HP:0012262)	1.68068305
99	3-Methylglutaconic aciduria (HP:0003535)	1.67761384
100	IgG deficiency (HP:0004315)	1.67137258

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.64942640
2	NUAK1	3.22215607
3	WNK3	2.97011634
4	TRIM28	2.84400844
5	MAP4K2	2.82575122
6	PINK1	2.71770811
7	ACVR1B	2.45570059
8	BMPR1B	2.22925686
9	MAPK13	2.19079400
10	ZAK	2.13465138
11	PLK4	2.07607749
12	ADRBK2	1.91489834
13	TXK	1.86880997
14	CASK	1.83463705
15	CDK8	1.75295187
16	BCR	1.74343447
17	OXSR1	1.66318410
18	GRK1	1.60547847
19	MAP3K4	1.60096285
20	TAOK3	1.53556079
21	CDK19	1.47248386
22	STK38L	1.45533868
23	BCKDK	1.36964168
24	MKNK2	1.36202414
25	ERBB3	1.35888411
26	DYRK3	1.35780597
27	INSRR	1.28479650
28	MST4	1.25287793
29	PLK2	1.25090960
30	BRSK2	1.17319412
31	CAMKK2	1.11539638
32	MAP2K7	1.08646585
33	SRPK1	1.07889862
34	TLK1	1.06052009
35	WNK4	1.03918650
36	EIF2AK3	1.03233186
37	PRKCE	0.99060971
38	PAK3	0.95339340
39	CSNK1G2	0.93598919
40	DAPK2	0.92388049
41	VRK1	0.91646077
42	MKNK1	0.88678288
43	EPHA4	0.85773685
44	STK3	0.85556158
45	CSNK1G1	0.85399470
46	CSNK1G3	0.82603127
47	MARK1	0.81696482
48	PTK2B	0.81557725
49	DYRK2	0.79431195
50	CSNK1A1L	0.78035733
51	PKN1	0.75861311
52	MAP3K7	0.74280559
53	MATK	0.74272766
54	AKT3	0.73839340
55	OBSCN	0.70649070
56	STK39	0.69638280
57	PIK3CA	0.69216671
58	ATR	0.64422226
59	GRK6	0.62287052
60	TEC	0.58553557
61	PRKCQ	0.58389755
62	PRKCG	0.57992148
63	SGK2	0.57644138
64	ADRBK1	0.57517764
65	CCNB1	0.57331009
66	TNK2	0.57163008
67	FER	0.56492376
68	RPS6KA4	0.56368132
69	KIT	0.54746438
70	DYRK1A	0.54009506
71	PIK3CG	0.50306147
72	PLK3	0.50197972
73	RPS6KA5	0.48646031
74	MARK3	0.48585809
75	CAMK2A	0.48437585
76	PIM1	0.48409561
77	LATS1	0.48137372
78	SIK3	0.45918256
79	PHKG2	0.42340795
80	PHKG1	0.42340795
81	TGFBR1	0.41036096
82	ATM	0.40911083
83	PRKACA	0.40808193
84	CSNK1A1	0.40711257
85	TNIK	0.40455273
86	PRKG1	0.40217376
87	ITK	0.39256888
88	ERBB2	0.38454754
89	SYK	0.37250434
90	IKBKE	0.34996898
91	MAP2K2	0.34638113
92	PRKACB	0.34376926
93	IKBKB	0.33864786
94	EPHA3	0.33661412
95	MINK1	0.33361227
96	CSNK1D	0.32295013
97	LYN	0.30881759
98	PLK1	0.30577509
99	EIF2AK2	0.30390227
100	RPS6KB1	0.29816619

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.59097938
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.66202873
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.56467656
4	Butanoate metabolism_Homo sapiens_hsa00650	2.49071064
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.45084110
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.38233012
7	Phototransduction_Homo sapiens_hsa04744	2.30482715
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.23683891
9	Protein export_Homo sapiens_hsa03060	2.21225389
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.11096270
11	Basal transcription factors_Homo sapiens_hsa03022	2.08128683
12	Selenocompound metabolism_Homo sapiens_hsa00450	2.06335310
13	Nitrogen metabolism_Homo sapiens_hsa00910	2.06191399
14	Caffeine metabolism_Homo sapiens_hsa00232	2.04186568
15	Propanoate metabolism_Homo sapiens_hsa00640	1.99533733
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.95951133
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.95822752
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.89995527
19	Homologous recombination_Homo sapiens_hsa03440	1.89822218
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.71324595
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.64166056
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.63565009
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.62829116
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.61533531
25	Nicotine addiction_Homo sapiens_hsa05033	1.60593714
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.53082382
27	RNA degradation_Homo sapiens_hsa03018	1.51635612
28	Olfactory transduction_Homo sapiens_hsa04740	1.40133833
29	Peroxisome_Homo sapiens_hsa04146	1.37936113
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.36474833
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.31959755
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.27349833
33	Taste transduction_Homo sapiens_hsa04742	1.27218722
34	Oxidative phosphorylation_Homo sapiens_hsa00190	1.25512544
35	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.24550778
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.22570338
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.14501103
38	Retinol metabolism_Homo sapiens_hsa00830	1.13870616
39	ABC transporters_Homo sapiens_hsa02010	1.12165261
40	Regulation of autophagy_Homo sapiens_hsa04140	1.10560419
41	Primary immunodeficiency_Homo sapiens_hsa05340	1.05012954
42	RNA polymerase_Homo sapiens_hsa03020	1.04635138
43	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.04045107
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03716113
45	Parkinsons disease_Homo sapiens_hsa05012	1.03580021
46	Circadian rhythm_Homo sapiens_hsa04710	1.03448302
47	Fatty acid degradation_Homo sapiens_hsa00071	0.99776129
48	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.98494259
49	Fatty acid metabolism_Homo sapiens_hsa01212	0.91683069
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90539127
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.89320441
52	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.88550643
53	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.87496120
54	Sulfur metabolism_Homo sapiens_hsa00920	0.85844463
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.85364878
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81923696
57	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.80127843
58	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.78437619
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74220793
60	Fatty acid elongation_Homo sapiens_hsa00062	0.73189610
61	Morphine addiction_Homo sapiens_hsa05032	0.72806318
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.70365273
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.70044423
64	Base excision repair_Homo sapiens_hsa03410	0.68290919
65	Serotonergic synapse_Homo sapiens_hsa04726	0.66058403
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.65586897
67	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.65559056
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.65491674
69	GABAergic synapse_Homo sapiens_hsa04727	0.64179790
70	Metabolic pathways_Homo sapiens_hsa01100	0.64140952
71	Purine metabolism_Homo sapiens_hsa00230	0.60535816
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58735611
73	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.58123700
74	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57775987
75	Circadian entrainment_Homo sapiens_hsa04713	0.56884201
76	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.56205454
77	Huntingtons disease_Homo sapiens_hsa05016	0.53624068
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52197871
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50656041
80	RNA transport_Homo sapiens_hsa03013	0.49370117
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.49003428
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.48199629
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46459791
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45722616
85	Long-term depression_Homo sapiens_hsa04730	0.45058157
86	Dopaminergic synapse_Homo sapiens_hsa04728	0.44139380
87	p53 signaling pathway_Homo sapiens_hsa04115	0.40915295
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.38041918
89	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.37092865
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36757353
91	Alzheimers disease_Homo sapiens_hsa05010	0.35344850
92	Mismatch repair_Homo sapiens_hsa03430	0.33667518
93	Histidine metabolism_Homo sapiens_hsa00340	0.33275208
94	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.32903085
95	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.32565278
96	Pyrimidine metabolism_Homo sapiens_hsa00240	0.31147906
97	One carbon pool by folate_Homo sapiens_hsa00670	0.30187540
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.30058183
99	Salivary secretion_Homo sapiens_hsa04970	0.26938569
100	Oocyte meiosis_Homo sapiens_hsa04114	0.26298589

ZNF564

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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