ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.37762172
2	behavioral response to nicotine (GO:0035095)	4.23558082
3	gamma-aminobutyric acid transport (GO:0015812)	3.95442378
4	neural tube formation (GO:0001841)	3.57521868
5	pyrimidine nucleobase catabolic process (GO:0006208)	3.57244448
6	DNA double-strand break processing (GO:0000729)	3.54037579
7	water-soluble vitamin biosynthetic process (GO:0042364)	3.45280645
8	L-fucose catabolic process (GO:0042355)	3.44084967
9	fucose catabolic process (GO:0019317)	3.44084967
10	L-fucose metabolic process (GO:0042354)	3.44084967
11	platelet dense granule organization (GO:0060155)	3.37507318
12	regulation of hexokinase activity (GO:1903299)	3.30615766
13	regulation of glucokinase activity (GO:0033131)	3.30615766
14	protein-cofactor linkage (GO:0018065)	3.27490319
15	nonmotile primary cilium assembly (GO:0035058)	3.27169123
16	DNA deamination (GO:0045006)	3.16525074
17	indolalkylamine metabolic process (GO:0006586)	3.14627954
18	replication fork processing (GO:0031297)	3.12116730
19	nucleobase catabolic process (GO:0046113)	3.09541316
20	negative regulation of telomere maintenance (GO:0032205)	3.06542004
21	respiratory chain complex IV assembly (GO:0008535)	3.06009909
22	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.00576917
23	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.00576917
24	protein complex biogenesis (GO:0070271)	2.96918929
25	kynurenine metabolic process (GO:0070189)	2.96417522
26	protein polyglutamylation (GO:0018095)	2.92592130
27	cytochrome complex assembly (GO:0017004)	2.92028487
28	indolalkylamine catabolic process (GO:0046218)	2.90662022
29	tryptophan catabolic process (GO:0006569)	2.90662022
30	indole-containing compound catabolic process (GO:0042436)	2.90662022
31	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.88036945
32	piRNA metabolic process (GO:0034587)	2.87256933
33	epithelial cilium movement (GO:0003351)	2.85706591
34	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.84836161
35	glycosphingolipid biosynthetic process (GO:0006688)	2.81019498
36	detection of light stimulus involved in visual perception (GO:0050908)	2.80116274
37	detection of light stimulus involved in sensory perception (GO:0050962)	2.80116274
38	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.80017430
39	mitochondrial respiratory chain complex assembly (GO:0033108)	2.79950493
40	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.79894725
41	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.79857480
42	kidney morphogenesis (GO:0060993)	2.78476040
43	ubiquinone metabolic process (GO:0006743)	2.78237710
44	presynaptic membrane assembly (GO:0097105)	2.78209090
45	regulation of timing of cell differentiation (GO:0048505)	2.76680452
46	protein localization to cilium (GO:0061512)	2.75667649
47	preassembly of GPI anchor in ER membrane (GO:0016254)	2.75538508
48	cilium morphogenesis (GO:0060271)	2.75156221
49	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.74013005
50	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.74013005
51	regulation of translation, ncRNA-mediated (GO:0045974)	2.74013005
52	positive regulation of mitochondrial fission (GO:0090141)	2.73969221
53	protein K6-linked ubiquitination (GO:0085020)	2.73946214
54	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.72671792
55	regulation of development, heterochronic (GO:0040034)	2.72139638
56	regulation of telomere maintenance (GO:0032204)	2.71732235
57	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.69711485
58	neuronal action potential (GO:0019228)	2.68147236
59	ubiquinone biosynthetic process (GO:0006744)	2.66885192
60	spinal cord motor neuron differentiation (GO:0021522)	2.66725178
61	intraciliary transport (GO:0042073)	2.66314776
62	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.65176696
63	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.65176696
64	NADH dehydrogenase complex assembly (GO:0010257)	2.65176696
65	C4-dicarboxylate transport (GO:0015740)	2.64014712
66	resolution of meiotic recombination intermediates (GO:0000712)	2.63461734
67	sulfation (GO:0051923)	2.63317715
68	limb bud formation (GO:0060174)	2.61881643
69	organelle disassembly (GO:1903008)	2.61640008
70	tryptophan metabolic process (GO:0006568)	2.59877922
71	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.59756921
72	photoreceptor cell maintenance (GO:0045494)	2.59649233
73	recombinational repair (GO:0000725)	2.59629976
74	synapsis (GO:0007129)	2.59390176
75	cilium organization (GO:0044782)	2.58133773
76	axoneme assembly (GO:0035082)	2.57015818
77	double-strand break repair via homologous recombination (GO:0000724)	2.56230769
78	postsynaptic membrane organization (GO:0001941)	2.53037275
79	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.52305748
80	cilium assembly (GO:0042384)	2.51773241
81	cornea development in camera-type eye (GO:0061303)	2.51696709
82	reciprocal DNA recombination (GO:0035825)	2.49819660
83	reciprocal meiotic recombination (GO:0007131)	2.49819660
84	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.48393829
85	indole-containing compound metabolic process (GO:0042430)	2.48264057
86	photoreceptor cell development (GO:0042461)	2.47317227
87	anterograde synaptic vesicle transport (GO:0048490)	2.47269496
88	regulation of cilium movement (GO:0003352)	2.46205135
89	behavioral response to ethanol (GO:0048149)	2.44128954
90	somite development (GO:0061053)	2.43512353
91	head development (GO:0060322)	2.42715901
92	regulation of mesoderm development (GO:2000380)	2.42124541
93	regulation of hippo signaling (GO:0035330)	2.41686300
94	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.40524272
95	retinal cone cell development (GO:0046549)	2.40457686
96	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.39092053
97	protein K11-linked deubiquitination (GO:0035871)	2.38281549
98	presynaptic membrane organization (GO:0097090)	2.37639027
99	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.37566787
100	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.36438006

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.00475178
2	VDR_22108803_ChIP-Seq_LS180_Human	3.22989490
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.11423705
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.97347549
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.80325650
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.68778891
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.63310577
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.56778872
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.46867865
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.35030576
11	EWS_26573619_Chip-Seq_HEK293_Human	2.28997936
12	FUS_26573619_Chip-Seq_HEK293_Human	2.28973314
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.26481759
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.25620496
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.24214681
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.14331887
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10503275
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.09544695
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.08253429
20	P300_19829295_ChIP-Seq_ESCs_Human	2.05779682
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.91544141
22	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.85325214
23	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.82196078
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.81542767
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.77321447
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.75455568
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72521374
28	* EST1_17652178_ChIP-ChIP_JURKAT_Human	1.72424363
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.70740365
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.64404502
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.59656562
32	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.58655830
33	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58505446
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.56911034
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53603339
36	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52854899
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.49536465
38	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49287780
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47810197
40	* NOTCH1_21737748_ChIP-Seq_TLL_Human	1.47484175
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.46854705
42	* STAT3_23295773_ChIP-Seq_U87_Human	1.46453271
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.45341706
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45341706
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45118916
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.44957839
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44080608
48	ELK1_19687146_ChIP-ChIP_HELA_Human	1.40945568
49	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.39416227
50	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.38724059
51	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.38217246
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36486049
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36414108
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34858708
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.34858708
56	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34758574
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34045976
58	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32734993
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.32655976
60	AR_25329375_ChIP-Seq_VCAP_Human	1.30835989
61	TCF4_23295773_ChIP-Seq_U87_Human	1.29900553
62	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29646833
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27487865
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25540485
65	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23986189
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23447649
67	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.23073679
68	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21969461
69	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20516853
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.17081933
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15885115
72	VDR_23849224_ChIP-Seq_CD4+_Human	1.15379446
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14178582
74	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.13412406
75	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13247194
76	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13247194
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12539217
78	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.10713260
79	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08673825
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07233134
81	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05553290
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05042720
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05042720
84	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03396721
85	AR_21572438_ChIP-Seq_LNCaP_Human	1.03364715
86	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.03150123
87	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03079413
88	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.01956205
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01172138
90	NCOR_22424771_ChIP-Seq_293T_Human	1.01083558
91	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97922971
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97676919
93	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.96773246
94	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.96591914
95	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.96455479
96	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.96331758
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96098191
98	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.95294835
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94931333
100	* ETS1_20019798_ChIP-Seq_JURKAT_Human	0.94762956

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	2.93735620
2	MP0002102_abnormal_ear_morphology	2.89435533
3	MP0008877_abnormal_DNA_methylation	2.74414991
4	MP0006292_abnormal_olfactory_placode	2.72912707
5	MP0003787_abnormal_imprinting	2.27478225
6	MP0001968_abnormal_touch/_nociception	2.21373360
7	MP0005551_abnormal_eye_electrophysiolog	2.04757125
8	MP0001986_abnormal_taste_sensitivity	2.02159653
9	MP0000569_abnormal_digit_pigmentation	1.97933236
10	MP0002736_abnormal_nociception_after	1.96615149
11	MP0006276_abnormal_autonomic_nervous	1.94363300
12	MP0005645_abnormal_hypothalamus_physiol	1.93870554
13	MP0002837_dystrophic_cardiac_calcinosis	1.87881582
14	MP0004133_heterotaxia	1.85627863
15	MP0008058_abnormal_DNA_repair	1.83688429
16	MP0009745_abnormal_behavioral_response	1.80407047
17	MP0009046_muscle_twitch	1.79276822
18	MP0001529_abnormal_vocalization	1.79002318
19	MP0003195_calcinosis	1.78621764
20	MP0003646_muscle_fatigue	1.78545097
21	MP0002735_abnormal_chemical_nociception	1.77264156
22	MP0004142_abnormal_muscle_tone	1.75111225
23	MP0000631_abnormal_neuroendocrine_gland	1.74939205
24	MP0006072_abnormal_retinal_apoptosis	1.73756460
25	MP0005423_abnormal_somatic_nervous	1.68158931
26	MP0003890_abnormal_embryonic-extraembry	1.64984331
27	MP0005646_abnormal_pituitary_gland	1.61835340
28	MP0002938_white_spotting	1.60186813
29	MP0002234_abnormal_pharynx_morphology	1.59800995
30	MP0002272_abnormal_nervous_system	1.57179024
31	MP0005253_abnormal_eye_physiology	1.55204208
32	MP0000427_abnormal_hair_cycle	1.52580334
33	MP0003122_maternal_imprinting	1.51546081
34	MP0001984_abnormal_olfaction	1.50892692
35	MP0003121_genomic_imprinting	1.49188917
36	MP0001188_hyperpigmentation	1.47863140
37	MP0003136_yellow_coat_color	1.47130228
38	MP0001486_abnormal_startle_reflex	1.41683774
39	MP0008872_abnormal_physiological_respon	1.39389929
40	MP0003635_abnormal_synaptic_transmissio	1.37154538
41	MP0002572_abnormal_emotion/affect_behav	1.36763579
42	MP0004043_abnormal_pH_regulation	1.36544502
43	MP0002557_abnormal_social/conspecific_i	1.34882429
44	MP0002638_abnormal_pupillary_reflex	1.34257442
45	MP0000778_abnormal_nervous_system	1.32107853
46	MP0003283_abnormal_digestive_organ	1.31856375
47	MP0004885_abnormal_endolymph	1.30492367
48	MP0008789_abnormal_olfactory_epithelium	1.28410733
49	MP0004147_increased_porphyrin_level	1.26599593
50	MP0005084_abnormal_gallbladder_morpholo	1.25311918
51	MP0002064_seizures	1.24814295
52	MP0002876_abnormal_thyroid_physiology	1.24449744
53	MP0002734_abnormal_mechanical_nocicepti	1.23087696
54	MP0002063_abnormal_learning/memory/cond	1.21987002
55	MP0003718_maternal_effect	1.21788848
56	MP0001485_abnormal_pinna_reflex	1.19429547
57	MP0004924_abnormal_behavior	1.19419220
58	MP0005386_behavior/neurological_phenoty	1.19419220
59	MP0002067_abnormal_sensory_capabilities	1.19123396
60	MP0002653_abnormal_ependyma_morphology	1.17514854
61	MP0000372_irregular_coat_pigmentation	1.14270389
62	MP0000049_abnormal_middle_ear	1.13177922
63	MP0002733_abnormal_thermal_nociception	1.12707509
64	MP0003119_abnormal_digestive_system	1.11479238
65	MP0003011_delayed_dark_adaptation	1.10630847
66	MP0003937_abnormal_limbs/digits/tail_de	1.09681788
67	MP0002751_abnormal_autonomic_nervous	1.08818640
68	MP0001501_abnormal_sleep_pattern	1.07637849
69	MP0001293_anophthalmia	1.07482477
70	MP0000647_abnormal_sebaceous_gland	1.07138505
71	MP0005187_abnormal_penis_morphology	1.07124585
72	MP0008995_early_reproductive_senescence	1.06949592
73	MP0001970_abnormal_pain_threshold	1.06026562
74	MP0002160_abnormal_reproductive_system	1.04392685
75	MP0008875_abnormal_xenobiotic_pharmacok	1.04103092
76	MP0002928_abnormal_bile_duct	1.02873819
77	MP0002184_abnormal_innervation	1.01461192
78	MP0003567_abnormal_fetal_cardiomyocyte	0.99650731
79	MP0004145_abnormal_muscle_electrophysio	0.97632671
80	MP0005379_endocrine/exocrine_gland_phen	0.97352793
81	MP0005394_taste/olfaction_phenotype	0.97092043
82	MP0005499_abnormal_olfactory_system	0.97092043
83	MP0005195_abnormal_posterior_eye	0.95960145
84	MP0005389_reproductive_system_phenotype	0.95185723
85	MP0000566_synostosis	0.94788406
86	MP0000383_abnormal_hair_follicle	0.94727384
87	MP0002752_abnormal_somatic_nervous	0.93625512
88	MP0003698_abnormal_male_reproductive	0.93267186
89	MP0001929_abnormal_gametogenesis	0.89638906
90	MP0004859_abnormal_synaptic_plasticity	0.88066858
91	MP0001905_abnormal_dopamine_level	0.87666683
92	MP0002210_abnormal_sex_determination	0.87343336
93	MP0004215_abnormal_myocardial_fiber	0.85181251
94	MP0000955_abnormal_spinal_cord	0.83709752
95	MP0004742_abnormal_vestibular_system	0.83548826
96	MP0003137_abnormal_impulse_conducting	0.83534439
97	MP0006035_abnormal_mitochondrial_morpho	0.83321568
98	MP0002163_abnormal_gland_morphology	0.83180997
99	MP0002095_abnormal_skin_pigmentation	0.83130611
100	MP0001919_abnormal_reproductive_system	0.82660241

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.00874324
2	Pancreatic fibrosis (HP:0100732)	3.92352006
3	True hermaphroditism (HP:0010459)	3.68233121
4	Abnormality of midbrain morphology (HP:0002418)	3.61754504
5	Molar tooth sign on MRI (HP:0002419)	3.61754504
6	Nephronophthisis (HP:0000090)	3.35048490
7	Hyperventilation (HP:0002883)	3.31803118
8	Medial flaring of the eyebrow (HP:0010747)	3.18522839
9	Congenital stationary night blindness (HP:0007642)	2.89693670
10	Abnormality of the renal medulla (HP:0100957)	2.88680873
11	Abnormality of the labia minora (HP:0012880)	2.81557890
12	Progressive inability to walk (HP:0002505)	2.81118893
13	Type II lissencephaly (HP:0007260)	2.80745030
14	Chronic hepatic failure (HP:0100626)	2.78954635
15	Gait imbalance (HP:0002141)	2.77803666
16	Inability to walk (HP:0002540)	2.74472123
17	Congenital primary aphakia (HP:0007707)	2.63227545
18	Abnormality of the renal cortex (HP:0011035)	2.62538457
19	Polydipsia (HP:0001959)	2.47162357
20	Abnormal drinking behavior (HP:0030082)	2.47162357
21	Nephrogenic diabetes insipidus (HP:0009806)	2.47046796
22	Attenuation of retinal blood vessels (HP:0007843)	2.43130052
23	Broad-based gait (HP:0002136)	2.37986535
24	Genital tract atresia (HP:0001827)	2.37779558
25	Lissencephaly (HP:0001339)	2.35741091
26	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.35217059
27	Abnormality of alanine metabolism (HP:0010916)	2.35217059
28	Hyperalaninemia (HP:0003348)	2.35217059
29	Cystic liver disease (HP:0006706)	2.34513823
30	Colon cancer (HP:0003003)	2.29059792
31	Vaginal atresia (HP:0000148)	2.28009803
32	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.27512475
33	Anencephaly (HP:0002323)	2.27406272
34	Abolished electroretinogram (ERG) (HP:0000550)	2.26553197
35	Cerebellar dysplasia (HP:0007033)	2.25571960
36	Pendular nystagmus (HP:0012043)	2.25476617
37	Methylmalonic acidemia (HP:0002912)	2.23411226
38	Genetic anticipation (HP:0003743)	2.20372081
39	Febrile seizures (HP:0002373)	2.18594895
40	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.18530597
41	Postaxial foot polydactyly (HP:0001830)	2.15937323
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.15779395
43	Drooling (HP:0002307)	2.15613010
44	Hypothermia (HP:0002045)	2.14851032
45	Atonic seizures (HP:0010819)	2.13869841
46	Focal motor seizures (HP:0011153)	2.11570780
47	Oligodactyly (hands) (HP:0001180)	2.11396500
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.11158057
49	Sclerocornea (HP:0000647)	2.10030679
50	Intestinal atresia (HP:0011100)	2.08184264
51	Progressive cerebellar ataxia (HP:0002073)	2.07993621
52	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.05739990
53	Gaze-evoked nystagmus (HP:0000640)	2.05670184
54	Renal cortical cysts (HP:0000803)	2.04651886
55	Tubular atrophy (HP:0000092)	2.01193696
56	Small hand (HP:0200055)	1.98196533
57	Optic nerve hypoplasia (HP:0000609)	1.97865410
58	Concave nail (HP:0001598)	1.97259097
59	Large for gestational age (HP:0001520)	1.93339937
60	Poor coordination (HP:0002370)	1.92245421
61	Absent speech (HP:0001344)	1.91918330
62	Polyuria (HP:0000103)	1.90626782
63	Postaxial hand polydactyly (HP:0001162)	1.90332877
64	Excessive salivation (HP:0003781)	1.90208855
65	Methylmalonic aciduria (HP:0012120)	1.89720190
66	Birth length less than 3rd percentile (HP:0003561)	1.89613820
67	Congenital hepatic fibrosis (HP:0002612)	1.88011206
68	Decreased central vision (HP:0007663)	1.87985235
69	Protruding tongue (HP:0010808)	1.87236531
70	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.84565396
71	Keratoconus (HP:0000563)	1.84319844
72	Increased corneal curvature (HP:0100692)	1.84319844
73	Abnormality of the ileum (HP:0001549)	1.83629697
74	Patellar aplasia (HP:0006443)	1.83266496
75	Limb dystonia (HP:0002451)	1.82190996
76	Male pseudohermaphroditism (HP:0000037)	1.81887406
77	Hyperglycinemia (HP:0002154)	1.81627865
78	Mitochondrial inheritance (HP:0001427)	1.81008539
79	Furrowed tongue (HP:0000221)	1.80867242
80	Increased CSF lactate (HP:0002490)	1.80042844
81	Meckel diverticulum (HP:0002245)	1.79647834
82	Acute necrotizing encephalopathy (HP:0006965)	1.79638747
83	Abnormality of the pons (HP:0007361)	1.79544214
84	Hemiparesis (HP:0001269)	1.79293641
85	Volvulus (HP:0002580)	1.78923602
86	Short tibia (HP:0005736)	1.78524988
87	Preaxial hand polydactyly (HP:0001177)	1.78385618
88	Dialeptic seizures (HP:0011146)	1.75547300
89	Focal seizures (HP:0007359)	1.75519818
90	Hypoplasia of the pons (HP:0012110)	1.74511004
91	Aplasia/Hypoplasia of the patella (HP:0006498)	1.73860472
92	Narrow forehead (HP:0000341)	1.73278922
93	Specific learning disability (HP:0001328)	1.72965287
94	Dyskinesia (HP:0100660)	1.72515531
95	Pachygyria (HP:0001302)	1.71486251
96	Supernumerary spleens (HP:0009799)	1.71187211
97	Retinal dysplasia (HP:0007973)	1.70823198
98	Dandy-Walker malformation (HP:0001305)	1.70592824
99	Astigmatism (HP:0000483)	1.70276525
100	Anophthalmia (HP:0000528)	1.70108883

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.85152887
2	MAP3K4	2.87757605
3	WNK3	2.87200347
4	ADRBK2	2.84487688
5	MAP4K2	2.68201785
6	PINK1	2.49791268
7	ZAK	2.42939255
8	CASK	2.36840662
9	TLK1	2.20082526
10	BMPR1B	2.19599130
11	MAPK13	2.17746284
12	NUAK1	2.16622571
13	GRK1	2.04232528
14	INSRR	2.00190520
15	MAP2K7	1.98406118
16	MKNK2	1.85617058
17	MARK1	1.76400797
18	ACVR1B	1.74740125
19	TRIM28	1.72495883
20	WNK4	1.70297823
21	BCR	1.63556989
22	AKT3	1.54739746
23	TAOK3	1.45637306
24	OXSR1	1.44642002
25	TNIK	1.43175309
26	STK39	1.38600380
27	PAK3	1.31977918
28	MKNK1	1.29795850
29	DYRK2	1.29704389
30	CSNK1G2	1.28861389
31	BRSK2	1.25527747
32	PLK4	1.21306264
33	PRKCG	1.20630875
34	VRK1	1.14843647
35	CSNK1G1	1.13479968
36	PLK2	1.13209617
37	STK38L	1.12796411
38	PNCK	1.10237008
39	CSNK1G3	1.10064539
40	PRKCE	1.01467650
41	CAMKK2	0.99707530
42	ERBB3	0.99019525
43	CSNK1A1L	0.98866165
44	PLK3	0.98673672
45	DAPK2	0.91609240
46	BCKDK	0.89995780
47	EPHA4	0.89496636
48	WEE1	0.84332599
49	EIF2AK3	0.82847896
50	PHKG2	0.81209883
51	PHKG1	0.81209883
52	SRPK1	0.78536837
53	FGFR2	0.76597789
54	LATS1	0.74965118
55	MAP2K4	0.73348313
56	CDC7	0.73087110
57	ADRBK1	0.72520230
58	EPHA3	0.70901082
59	DYRK3	0.70421686
60	TGFBR1	0.70408406
61	MAPKAPK5	0.68374029
62	PIK3CA	0.68079333
63	MAPKAPK3	0.67100058
64	CAMK2A	0.64149033
65	STK3	0.61520891
66	NTRK2	0.61285130
67	PLK1	0.58516864
68	TSSK6	0.57104073
69	OBSCN	0.56662392
70	RPS6KA5	0.55918403
71	BUB1	0.52745994
72	PRKCI	0.49694001
73	SGK2	0.47806725
74	MST4	0.46785684
75	PKN1	0.45164128
76	PRKAA1	0.44523212
77	NEK1	0.43743380
78	CDK3	0.43628040
79	ATR	0.43375267
80	MAPK15	0.43373745
81	NEK2	0.43349555
82	RPS6KA4	0.43264365
83	CDK19	0.41788136
84	CHEK2	0.41251052
85	PRKACA	0.41217228
86	SGK223	0.41150730
87	SGK494	0.41150730
88	PTK2B	0.39622627
89	TIE1	0.39245050
90	NME1	0.39126598
91	CSNK1A1	0.39061667
92	ATM	0.39011506
93	CSNK1D	0.37880829
94	CCNB1	0.37311327
95	CAMK1	0.36461011
96	CAMK2B	0.34892146
97	NTRK3	0.33845924
98	PRKG1	0.33602909
99	CAMK4	0.33112042
100	EIF2AK2	0.32949451

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.83565177
2	Phototransduction_Homo sapiens_hsa04744	2.46935145
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.45291490
4	Protein export_Homo sapiens_hsa03060	2.42862247
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.38948959
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.32264569
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.26296157
8	Butanoate metabolism_Homo sapiens_hsa00650	2.15546363
9	Basal transcription factors_Homo sapiens_hsa03022	2.15452738
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.12291394
11	Homologous recombination_Homo sapiens_hsa03440	2.02500119
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.00861643
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.96476340
14	RNA polymerase_Homo sapiens_hsa03020	1.94836110
15	Propanoate metabolism_Homo sapiens_hsa00640	1.87534661
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.86446522
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.85927939
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.80854538
19	Parkinsons disease_Homo sapiens_hsa05012	1.79051388
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.78252972
21	Taste transduction_Homo sapiens_hsa04742	1.78183428
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.67551770
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.62993647
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.62515056
25	RNA degradation_Homo sapiens_hsa03018	1.61815410
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.53272151
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.51229264
28	Caffeine metabolism_Homo sapiens_hsa00232	1.44811639
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.44529305
30	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.41164621
31	Morphine addiction_Homo sapiens_hsa05032	1.39480034
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.38382943
33	GABAergic synapse_Homo sapiens_hsa04727	1.37027445
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.31455130
35	Non-homologous end-joining_Homo sapiens_hsa03450	1.29654368
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.25819384
37	Regulation of autophagy_Homo sapiens_hsa04140	1.25492826
38	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.18597411
39	Olfactory transduction_Homo sapiens_hsa04740	1.18465764
40	Huntingtons disease_Homo sapiens_hsa05016	1.16832720
41	Cardiac muscle contraction_Homo sapiens_hsa04260	1.14444266
42	Peroxisome_Homo sapiens_hsa04146	1.10138360
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.06158052
44	Glutamatergic synapse_Homo sapiens_hsa04724	1.04825759
45	Circadian entrainment_Homo sapiens_hsa04713	1.04690635
46	Alzheimers disease_Homo sapiens_hsa05010	1.03439493
47	One carbon pool by folate_Homo sapiens_hsa00670	0.99923305
48	Serotonergic synapse_Homo sapiens_hsa04726	0.98797617
49	Insulin secretion_Homo sapiens_hsa04911	0.94225791
50	Mismatch repair_Homo sapiens_hsa03430	0.91573113
51	Sulfur relay system_Homo sapiens_hsa04122	0.89992548
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87686275
53	RNA transport_Homo sapiens_hsa03013	0.86855542
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83708484
55	Purine metabolism_Homo sapiens_hsa00230	0.83233405
56	ABC transporters_Homo sapiens_hsa02010	0.81772194
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80999127
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80861971
59	Cocaine addiction_Homo sapiens_hsa05030	0.79659452
60	Dopaminergic synapse_Homo sapiens_hsa04728	0.76230363
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.75613099
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.73763961
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.73672622
64	Retinol metabolism_Homo sapiens_hsa00830	0.71433722
65	Amphetamine addiction_Homo sapiens_hsa05031	0.71095635
66	Nucleotide excision repair_Homo sapiens_hsa03420	0.70106871
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.69996438
68	Base excision repair_Homo sapiens_hsa03410	0.69502228
69	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.69136657
70	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.68641296
71	Circadian rhythm_Homo sapiens_hsa04710	0.67880503
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66251274
73	Salivary secretion_Homo sapiens_hsa04970	0.66137639
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.65580259
75	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.65408190
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.63860355
77	Long-term depression_Homo sapiens_hsa04730	0.63837429
78	Metabolic pathways_Homo sapiens_hsa01100	0.62106015
79	Fatty acid elongation_Homo sapiens_hsa00062	0.60081689
80	Proteasome_Homo sapiens_hsa03050	0.59439688
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.59294255
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58195541
83	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.56831416
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.54780005
85	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.54694985
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.48740778
87	Sulfur metabolism_Homo sapiens_hsa00920	0.48317284
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.47808889
89	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.47213634
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.46994827
91	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45166600
92	Fat digestion and absorption_Homo sapiens_hsa04975	0.43713498
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40940531
94	Basal cell carcinoma_Homo sapiens_hsa05217	0.37419077
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36077692
96	Spliceosome_Homo sapiens_hsa03040	0.35826583
97	Axon guidance_Homo sapiens_hsa04360	0.34896782
98	Histidine metabolism_Homo sapiens_hsa00340	0.33667825
99	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.33643304
100	Oocyte meiosis_Homo sapiens_hsa04114	0.33516764

ZNF566

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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