ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.39487920
2	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.98519756
3	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.72743479
4	response to pheromone (GO:0019236)	3.69398345
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.67590652
6	platelet dense granule organization (GO:0060155)	3.56352549
7	DNA double-strand break processing (GO:0000729)	3.55860448
8	replication fork processing (GO:0031297)	3.53484200
9	negative regulation of telomere maintenance (GO:0032205)	3.47486186
10	respiratory chain complex IV assembly (GO:0008535)	3.42360089
11	protein-cofactor linkage (GO:0018065)	3.39715487
12	piRNA metabolic process (GO:0034587)	3.37416263
13	neural tube formation (GO:0001841)	3.37108693
14	L-fucose catabolic process (GO:0042355)	3.34414633
15	fucose catabolic process (GO:0019317)	3.34414633
16	L-fucose metabolic process (GO:0042354)	3.34414633
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.30318434
18	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.23538145
19	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.20335518
20	protein complex biogenesis (GO:0070271)	3.16593442
21	mitochondrial respiratory chain complex assembly (GO:0033108)	3.13511609
22	recombinational repair (GO:0000725)	3.12575319
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.09702948
24	NADH dehydrogenase complex assembly (GO:0010257)	3.09702948
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.09702948
26	double-strand break repair via homologous recombination (GO:0000724)	3.08976765
27	indolalkylamine catabolic process (GO:0046218)	3.07381349
28	tryptophan catabolic process (GO:0006569)	3.07381349
29	indole-containing compound catabolic process (GO:0042436)	3.07381349
30	cytochrome complex assembly (GO:0017004)	3.04184766
31	water-soluble vitamin biosynthetic process (GO:0042364)	3.03021688
32	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.02005946
33	regulation of mitotic spindle checkpoint (GO:1903504)	3.02005946
34	positive regulation of prostaglandin secretion (GO:0032308)	3.00654171
35	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.98231154
36	pseudouridine synthesis (GO:0001522)	2.97727267
37	reciprocal meiotic recombination (GO:0007131)	2.96719976
38	reciprocal DNA recombination (GO:0035825)	2.96719976
39	chromatin remodeling at centromere (GO:0031055)	2.92253653
40	indolalkylamine metabolic process (GO:0006586)	2.90327223
41	epithelial cilium movement (GO:0003351)	2.88659357
42	DNA deamination (GO:0045006)	2.88170785
43	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.85814924
44	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.85814924
45	histone mRNA metabolic process (GO:0008334)	2.85105246
46	preassembly of GPI anchor in ER membrane (GO:0016254)	2.83054834
47	kidney morphogenesis (GO:0060993)	2.80917963
48	axoneme assembly (GO:0035082)	2.79990717
49	ncRNA catabolic process (GO:0034661)	2.79553208
50	protein K6-linked ubiquitination (GO:0085020)	2.78974841
51	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.76683783
52	maturation of 5.8S rRNA (GO:0000460)	2.76141536
53	CENP-A containing nucleosome assembly (GO:0034080)	2.74873515
54	mannosylation (GO:0097502)	2.73414560
55	nonmotile primary cilium assembly (GO:0035058)	2.72685656
56	regulation of telomere maintenance (GO:0032204)	2.72196765
57	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.71966400
58	regulation of translation, ncRNA-mediated (GO:0045974)	2.71966400
59	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.71966400
60	peptidyl-histidine modification (GO:0018202)	2.71274237
61	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.69071128
62	ATP synthesis coupled proton transport (GO:0015986)	2.69071128
63	proteasome assembly (GO:0043248)	2.69034681
64	intraciliary transport (GO:0042073)	2.68947003
65	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.68685231
66	kynurenine metabolic process (GO:0070189)	2.67662858
67	meiotic chromosome segregation (GO:0045132)	2.67412919
68	sulfation (GO:0051923)	2.67204641
69	tryptophan metabolic process (GO:0006568)	2.62606221
70	GPI anchor metabolic process (GO:0006505)	2.59103210
71	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.58995809
72	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.58995809
73	cilium or flagellum-dependent cell motility (GO:0001539)	2.56843185
74	detection of light stimulus involved in sensory perception (GO:0050962)	2.56729295
75	detection of light stimulus involved in visual perception (GO:0050908)	2.56729295
76	cilium morphogenesis (GO:0060271)	2.56080527
77	spinal cord motor neuron differentiation (GO:0021522)	2.53973778
78	cilium organization (GO:0044782)	2.53824438
79	somite development (GO:0061053)	2.52721998
80	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.52024607
81	centriole replication (GO:0007099)	2.51973801
82	histone mRNA catabolic process (GO:0071044)	2.51663730
83	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.51284087
84	protein K11-linked deubiquitination (GO:0035871)	2.51167001
85	meiotic cell cycle (GO:0051321)	2.50789854
86	spliceosomal complex assembly (GO:0000245)	2.50752203
87	photoreceptor cell maintenance (GO:0045494)	2.49808839
88	histone-serine phosphorylation (GO:0035404)	2.49226423
89	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.48822477
90	histone exchange (GO:0043486)	2.47982571
91	neuronal action potential (GO:0019228)	2.47879615
92	rRNA catabolic process (GO:0016075)	2.47767562
93	tRNA processing (GO:0008033)	2.47054649
94	limb bud formation (GO:0060174)	2.45843033
95	cilium movement (GO:0003341)	2.45320612
96	synapsis (GO:0007129)	2.45258318
97	cilium assembly (GO:0042384)	2.44776119
98	microtubule anchoring (GO:0034453)	2.43945620
99	DNA replication checkpoint (GO:0000076)	2.43443675
100	regulation of cilium movement (GO:0003352)	2.43364689

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.83818450
2	VDR_22108803_ChIP-Seq_LS180_Human	3.20711397
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.78620894
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.75891383
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.67851279
6	* EST1_17652178_ChIP-ChIP_JURKAT_Human	2.60182418
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.57200515
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.56264343
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.52710148
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.48990806
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.43378150
12	FUS_26573619_Chip-Seq_HEK293_Human	2.42568779
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.39544949
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.34760991
15	EWS_26573619_Chip-Seq_HEK293_Human	2.33083457
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.33082030
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.18002504
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14220205
19	P300_19829295_ChIP-Seq_ESCs_Human	2.09485237
20	TAF15_26573619_Chip-Seq_HEK293_Human	2.06014477
21	ELK1_19687146_ChIP-ChIP_HELA_Human	2.00962975
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.94017390
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.90666255
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89822833
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.85416083
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.80350050
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.79797739
28	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.76460688
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.75666953
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68463210
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64635913
32	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.62408998
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.58628891
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.56846634
35	EZH2_22144423_ChIP-Seq_EOC_Human	1.56129472
36	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50778088
37	* ETS1_20019798_ChIP-Seq_JURKAT_Human	1.49952132
38	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.47486540
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.46317978
40	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.41154287
41	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41154287
42	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.38676899
43	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.38281236
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.37925354
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37671608
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35009359
47	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.34619108
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.31282301
49	FOXP3_21729870_ChIP-Seq_TREG_Human	1.30868693
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29334114
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29334114
52	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27529584
53	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.26982787
54	BCAT_22108803_ChIP-Seq_LS180_Human	1.26668036
55	STAT3_23295773_ChIP-Seq_U87_Human	1.25957540
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24850435
57	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.24691781
58	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.24516023
59	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24360876
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24360876
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23949969
62	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.23561917
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23120466
64	CBP_20019798_ChIP-Seq_JUKART_Human	1.23120466
65	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.21569789
66	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.21100610
67	SMAD4_21799915_ChIP-Seq_A2780_Human	1.19768419
68	AR_25329375_ChIP-Seq_VCAP_Human	1.19704823
69	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19219659
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17476651
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16686526
72	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.16286682
73	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14825463
74	TCF4_23295773_ChIP-Seq_U87_Human	1.14517677
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13509224
76	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.13254786
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.11418976
78	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11255085
79	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09191451
80	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.08760947
81	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.08028151
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07002298
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06333338
84	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.04385760
85	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.03998639
86	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03851009
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01444422
88	AR_20517297_ChIP-Seq_VCAP_Human	1.01098575
89	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.00703298
90	NCOR_22424771_ChIP-Seq_293T_Human	1.00592537
91	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99676190
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99630739
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98471477
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.97322807
95	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96886261
96	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.96764478
97	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.96515823
98	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.96361462
99	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.95833829
100	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.95585651

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.27709135
2	MP0006292_abnormal_olfactory_placode	2.70510878
3	MP0002102_abnormal_ear_morphology	2.69080794
4	MP0003195_calcinosis	2.53020155
5	MP0003136_yellow_coat_color	2.25731837
6	MP0008058_abnormal_DNA_repair	2.17331660
7	MP0003880_abnormal_central_pattern	2.16652787
8	MP0006072_abnormal_retinal_apoptosis	2.15443997
9	MP0005551_abnormal_eye_electrophysiolog	2.12481934
10	MP0001986_abnormal_taste_sensitivity	2.10738652
11	MP0004133_heterotaxia	2.07278150
12	MP0006276_abnormal_autonomic_nervous	1.98271049
13	MP0002938_white_spotting	1.97410756
14	MP0003787_abnormal_imprinting	1.81818002
15	MP0002234_abnormal_pharynx_morphology	1.78086614
16	MP0008872_abnormal_physiological_respon	1.76846499
17	MP0001968_abnormal_touch/_nociception	1.76493968
18	MP0005084_abnormal_gallbladder_morpholo	1.75958122
19	MP0003890_abnormal_embryonic-extraembry	1.73355886
20	MP0000427_abnormal_hair_cycle	1.66808782
21	MP0002736_abnormal_nociception_after	1.63986760
22	MP0005253_abnormal_eye_physiology	1.62871450
23	MP0000372_irregular_coat_pigmentation	1.62758858
24	MP0005645_abnormal_hypothalamus_physiol	1.62042002
25	MP0001293_anophthalmia	1.58489407
26	MP0002653_abnormal_ependyma_morphology	1.58133428
27	MP0000569_abnormal_digit_pigmentation	1.57004682
28	MP0004142_abnormal_muscle_tone	1.55439858
29	MP0004147_increased_porphyrin_level	1.53327508
30	MP0010094_abnormal_chromosome_stability	1.49792601
31	MP0003121_genomic_imprinting	1.49754592
32	MP0000631_abnormal_neuroendocrine_gland	1.48410237
33	MP0001529_abnormal_vocalization	1.48209642
34	MP0003011_delayed_dark_adaptation	1.47966376
35	MP0009745_abnormal_behavioral_response	1.45960297
36	MP0003718_maternal_effect	1.44246254
37	MP0005423_abnormal_somatic_nervous	1.43682580
38	MP0002837_dystrophic_cardiac_calcinosis	1.42692954
39	MP0002277_abnormal_respiratory_mucosa	1.40004820
40	MP0008995_early_reproductive_senescence	1.39923182
41	MP0001984_abnormal_olfaction	1.38533819
42	MP0003122_maternal_imprinting	1.38012686
43	MP0003119_abnormal_digestive_system	1.37029858
44	MP0002638_abnormal_pupillary_reflex	1.34977073
45	MP0001485_abnormal_pinna_reflex	1.33684534
46	MP0009046_muscle_twitch	1.31926561
47	MP0002751_abnormal_autonomic_nervous	1.31507775
48	MP0002735_abnormal_chemical_nociception	1.30459605
49	MP0002876_abnormal_thyroid_physiology	1.30044900
50	MP0002272_abnormal_nervous_system	1.26001411
51	MP0005646_abnormal_pituitary_gland	1.24962090
52	MP0008789_abnormal_olfactory_epithelium	1.20756696
53	MP0008875_abnormal_xenobiotic_pharmacok	1.19705507
54	MP0002210_abnormal_sex_determination	1.19571093
55	MP0003693_abnormal_embryo_hatching	1.18425593
56	MP0002928_abnormal_bile_duct	1.17786103
57	MP0001929_abnormal_gametogenesis	1.17129270
58	MP0004145_abnormal_muscle_electrophysio	1.13792440
59	MP0004043_abnormal_pH_regulation	1.12843112
60	MP0005174_abnormal_tail_pigmentation	1.12195377
61	MP0003646_muscle_fatigue	1.11334024
62	MP0002160_abnormal_reproductive_system	1.08977981
63	MP0005187_abnormal_penis_morphology	1.08058909
64	MP0003937_abnormal_limbs/digits/tail_de	1.07374413
65	MP0003283_abnormal_digestive_organ	1.06279704
66	MP0003698_abnormal_male_reproductive	1.05212199
67	MP0000383_abnormal_hair_follicle	1.04895791
68	MP0005075_abnormal_melanosome_morpholog	1.04183991
69	MP0001502_abnormal_circadian_rhythm	1.03290149
70	MP0004742_abnormal_vestibular_system	1.00947903
71	MP0000653_abnormal_sex_gland	0.99774460
72	MP0005410_abnormal_fertilization	0.98089767
73	MP0001324_abnormal_eye_pigmentation	0.97378725
74	MP0001145_abnormal_male_reproductive	0.96719944
75	MP0005389_reproductive_system_phenotype	0.96350119
76	MP0001486_abnormal_startle_reflex	0.95920677
77	MP0002572_abnormal_emotion/affect_behav	0.94497402
78	MP0002557_abnormal_social/conspecific_i	0.93226208
79	MP0004885_abnormal_endolymph	0.92079879
80	MP0003786_premature_aging	0.91568049
81	MP0000647_abnormal_sebaceous_gland	0.91061514
82	MP0005394_taste/olfaction_phenotype	0.90984222
83	MP0005499_abnormal_olfactory_system	0.90984222
84	MP0005195_abnormal_posterior_eye	0.90563851
85	MP0002163_abnormal_gland_morphology	0.89422821
86	MP0003567_abnormal_fetal_cardiomyocyte	0.86933322
87	MP0005367_renal/urinary_system_phenotyp	0.86231984
88	MP0000516_abnormal_urinary_system	0.86231984
89	MP0005391_vision/eye_phenotype	0.85561483
90	MP0002067_abnormal_sensory_capabilities	0.85184560
91	MP0001119_abnormal_female_reproductive	0.84836401
92	MP0000778_abnormal_nervous_system	0.84012200
93	MP0001970_abnormal_pain_threshold	0.83345571
94	MP0002733_abnormal_thermal_nociception	0.82506964
95	MP0008775_abnormal_heart_ventricle	0.82368431
96	MP0008057_abnormal_DNA_replication	0.82031833
97	MP0002752_abnormal_somatic_nervous	0.81509918
98	MP0005386_behavior/neurological_phenoty	0.80966904
99	MP0004924_abnormal_behavior	0.80966904
100	MP0006035_abnormal_mitochondrial_morpho	0.80717734

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.34063151
2	Pancreatic fibrosis (HP:0100732)	4.04212963
3	True hermaphroditism (HP:0010459)	3.86321577
4	Abnormality of midbrain morphology (HP:0002418)	3.84672329
5	Molar tooth sign on MRI (HP:0002419)	3.84672329
6	Nephronophthisis (HP:0000090)	3.37216003
7	Abnormality of the renal cortex (HP:0011035)	3.11027145
8	Congenital stationary night blindness (HP:0007642)	3.03716432
9	Hyperventilation (HP:0002883)	2.98017182
10	Chronic hepatic failure (HP:0100626)	2.93166320
11	Type II lissencephaly (HP:0007260)	2.92910268
12	Abnormality of the renal medulla (HP:0100957)	2.92470384
13	Abnormality of the labia minora (HP:0012880)	2.84264331
14	Medial flaring of the eyebrow (HP:0010747)	2.71881324
15	Birth length less than 3rd percentile (HP:0003561)	2.62928593
16	Renal cortical cysts (HP:0000803)	2.57813524
17	Cystic liver disease (HP:0006706)	2.56937404
18	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.53580735
19	Abnormality of alanine metabolism (HP:0010916)	2.53580735
20	Hyperalaninemia (HP:0003348)	2.53580735
21	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.47770804
22	Anencephaly (HP:0002323)	2.45028569
23	Bile duct proliferation (HP:0001408)	2.44238145
24	Abnormal biliary tract physiology (HP:0012439)	2.44238145
25	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.44223201
26	Attenuation of retinal blood vessels (HP:0007843)	2.43508468
27	Sclerocornea (HP:0000647)	2.42788672
28	Tubular atrophy (HP:0000092)	2.40791154
29	Methylmalonic aciduria (HP:0012120)	2.37664717
30	Colon cancer (HP:0003003)	2.36425023
31	Hypoplasia of the pons (HP:0012110)	2.33633838
32	3-Methylglutaconic aciduria (HP:0003535)	2.30706285
33	Abnormality of the pons (HP:0007361)	2.29562436
34	Abolished electroretinogram (ERG) (HP:0000550)	2.27517657
35	Methylmalonic acidemia (HP:0002912)	2.26684734
36	Inability to walk (HP:0002540)	2.25988648
37	Broad-based gait (HP:0002136)	2.25398397
38	Meckel diverticulum (HP:0002245)	2.23627529
39	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.22761093
40	Cerebellar dysplasia (HP:0007033)	2.22682627
41	Abnormality of the ileum (HP:0001549)	2.21545308
42	Progressive inability to walk (HP:0002505)	2.19974447
43	Pendular nystagmus (HP:0012043)	2.19871905
44	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.17963142
45	Furrowed tongue (HP:0000221)	2.17640275
46	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.16206395
47	Optic nerve hypoplasia (HP:0000609)	2.15832904
48	Gait imbalance (HP:0002141)	2.15375125
49	Supernumerary spleens (HP:0009799)	2.14915436
50	Absent/shortened dynein arms (HP:0200106)	2.13436464
51	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.13436464
52	Septo-optic dysplasia (HP:0100842)	2.13103340
53	Congenital primary aphakia (HP:0007707)	2.13014388
54	Abnormal drinking behavior (HP:0030082)	2.12732874
55	Polydipsia (HP:0001959)	2.12732874
56	Carpal bone hypoplasia (HP:0001498)	2.12300606
57	Short tibia (HP:0005736)	2.11662364
58	Chromsome breakage (HP:0040012)	2.10743046
59	Lissencephaly (HP:0001339)	2.07071314
60	Small hand (HP:0200055)	2.04377558
61	Acute necrotizing encephalopathy (HP:0006965)	2.04356935
62	Intestinal atresia (HP:0011100)	2.04032763
63	Abnormality of chromosome stability (HP:0003220)	2.03882819
64	Postaxial foot polydactyly (HP:0001830)	2.03181181
65	Congenital hepatic fibrosis (HP:0002612)	2.01555527
66	Abnormal rod and cone electroretinograms (HP:0008323)	2.00221079
67	Male pseudohermaphroditism (HP:0000037)	1.98994518
68	Dandy-Walker malformation (HP:0001305)	1.98216657
69	Optic disc pallor (HP:0000543)	1.97868000
70	Congenital, generalized hypertrichosis (HP:0004540)	1.97335189
71	Nephrogenic diabetes insipidus (HP:0009806)	1.97162425
72	Bilateral microphthalmos (HP:0007633)	1.97067991
73	Genital tract atresia (HP:0001827)	1.96350412
74	Abnormal number of erythroid precursors (HP:0012131)	1.96138557
75	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.96109036
76	Preaxial hand polydactyly (HP:0001177)	1.95873759
77	Acute encephalopathy (HP:0006846)	1.95772593
78	Increased CSF lactate (HP:0002490)	1.95194952
79	Mitochondrial inheritance (HP:0001427)	1.94216251
80	Sloping forehead (HP:0000340)	1.93264762
81	Patellar aplasia (HP:0006443)	1.91457693
82	Vaginal atresia (HP:0000148)	1.91128947
83	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.90007388
84	Abnormal respiratory epithelium morphology (HP:0012253)	1.88993167
85	Abnormal respiratory motile cilium morphology (HP:0005938)	1.88993167
86	Hyperglycinemia (HP:0002154)	1.87398794
87	Gaze-evoked nystagmus (HP:0000640)	1.87004058
88	Increased corneal curvature (HP:0100692)	1.84654333
89	Keratoconus (HP:0000563)	1.84654333
90	Decreased central vision (HP:0007663)	1.84170156
91	Clubbing of toes (HP:0100760)	1.82713032
92	Tubulointerstitial nephritis (HP:0001970)	1.81924570
93	Triphalangeal thumb (HP:0001199)	1.81377233
94	Hyperglycinuria (HP:0003108)	1.80742072
95	Lipid accumulation in hepatocytes (HP:0006561)	1.79778680
96	Concave nail (HP:0001598)	1.79429367
97	Abnormality of the preputium (HP:0100587)	1.79094246
98	Aplasia/Hypoplasia of the patella (HP:0006498)	1.78697166
99	Postaxial hand polydactyly (HP:0001162)	1.77101318
100	Increased hepatocellular lipid droplets (HP:0006565)	1.76866992

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.97782429
2	ZAK	3.41941870
3	WNK3	3.15805753
4	BMPR1B	3.03382126
5	NUAK1	2.66919638
6	ADRBK2	2.62329114
7	TLK1	2.40514735
8	MKNK2	2.37406241
9	MAP4K2	2.35423869
10	CASK	2.19901613
11	ACVR1B	2.05506330
12	MAP3K4	2.00691362
13	WNK4	1.90875112
14	TNIK	1.88256453
15	GRK1	1.80601755
16	TRIM28	1.72863469
17	INSRR	1.72391823
18	PNCK	1.71228226
19	MST4	1.65704616
20	BRSK2	1.65639503
21	MKNK1	1.64920968
22	VRK1	1.62573594
23	OXSR1	1.48664610
24	PLK3	1.38671383
25	SRPK1	1.36556449
26	WEE1	1.36552945
27	PLK4	1.32843957
28	TGFBR1	1.28030175
29	BUB1	1.24822141
30	MAPK13	1.24508600
31	PLK2	1.23777806
32	TSSK6	1.22072675
33	CDC7	1.22005071
34	PINK1	1.18499511
35	STK39	1.12953434
36	DYRK2	1.09778685
37	VRK2	1.07239568
38	BCR	1.06360631
39	MAP2K7	1.03519203
40	CDK19	1.03346929
41	TTK	1.01748350
42	MARK1	1.01184562
43	PLK1	1.00602268
44	TAOK3	1.00185474
45	BCKDK	0.97716895
46	TXK	0.90831238
47	PRKCE	0.87203139
48	ADRBK1	0.87060527
49	CSNK1G1	0.84033533
50	CSNK1G2	0.83537673
51	MAPK15	0.81955220
52	NLK	0.80521430
53	RPS6KA5	0.80057581
54	STK38L	0.80023560
55	ATR	0.77930361
56	CAMKK2	0.76681917
57	DAPK2	0.76330267
58	EIF2AK3	0.74226202
59	PRKCG	0.73764947
60	CSNK1G3	0.73733861
61	ERBB3	0.73623221
62	STK3	0.72451777
63	CHEK2	0.72053926
64	NEK2	0.71538736
65	PASK	0.71056338
66	DYRK3	0.70292224
67	IRAK1	0.69173695
68	PAK3	0.66816656
69	STK16	0.66084841
70	CSNK1A1L	0.61536420
71	TIE1	0.61352104
72	CDK8	0.61134420
73	ATM	0.59038663
74	EPHA3	0.58814731
75	AKT3	0.55414074
76	TEC	0.52679702
77	FGFR2	0.52180078
78	NME1	0.51598057
79	PKN1	0.50263375
80	FLT3	0.49562893
81	IKBKB	0.44727004
82	STK11	0.44642237
83	CDK3	0.44045247
84	PTK2B	0.43102865
85	PRKCI	0.42737672
86	CSNK1D	0.41527384
87	TAF1	0.39888711
88	CSNK1A1	0.39335887
89	MUSK	0.37638296
90	RPS6KA4	0.36917879
91	CAMK2A	0.35087576
92	CSNK2A1	0.34005624
93	EPHA4	0.33775343
94	PRKCQ	0.32676295
95	BRD4	0.32661992
96	EIF2AK2	0.32613426
97	PIK3CA	0.32288687
98	AURKB	0.31697734
99	PRKACA	0.30636045
100	DYRK1A	0.27888833

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	RNA polymerase_Homo sapiens_hsa03020	2.67519907
2	Homologous recombination_Homo sapiens_hsa03440	2.63441804
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.53614914
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.45275467
5	Protein export_Homo sapiens_hsa03060	2.40704819
6	Phototransduction_Homo sapiens_hsa04744	2.35540554
7	Basal transcription factors_Homo sapiens_hsa03022	2.30310775
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.28277242
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.26893031
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.19829996
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.19295792
12	RNA degradation_Homo sapiens_hsa03018	2.03283575
13	Parkinsons disease_Homo sapiens_hsa05012	2.02232712
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.02166829
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.96219536
16	Proteasome_Homo sapiens_hsa03050	1.89648855
17	One carbon pool by folate_Homo sapiens_hsa00670	1.85887901
18	Butanoate metabolism_Homo sapiens_hsa00650	1.83859211
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.80627375
20	Propanoate metabolism_Homo sapiens_hsa00640	1.79433393
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.79300246
22	Mismatch repair_Homo sapiens_hsa03430	1.74280151
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.73692228
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.65596383
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.62694821
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.49816118
27	Nicotine addiction_Homo sapiens_hsa05033	1.49406361
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.44838146
29	Huntingtons disease_Homo sapiens_hsa05016	1.43897611
30	Ribosome_Homo sapiens_hsa03010	1.35572267
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.31141878
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27041537
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.26827395
34	Olfactory transduction_Homo sapiens_hsa04740	1.26554423
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.25929919
36	RNA transport_Homo sapiens_hsa03013	1.25283531
37	Ether lipid metabolism_Homo sapiens_hsa00565	1.21517850
38	Peroxisome_Homo sapiens_hsa04146	1.21338096
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.18995282
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.18781138
41	Alzheimers disease_Homo sapiens_hsa05010	1.15381485
42	DNA replication_Homo sapiens_hsa03030	1.12883170
43	Regulation of autophagy_Homo sapiens_hsa04140	1.12632227
44	Purine metabolism_Homo sapiens_hsa00230	1.12086844
45	Pyrimidine metabolism_Homo sapiens_hsa00240	1.11964961
46	Base excision repair_Homo sapiens_hsa03410	1.11778775
47	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.10720947
48	Caffeine metabolism_Homo sapiens_hsa00232	1.08168759
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.05530796
50	Taste transduction_Homo sapiens_hsa04742	1.05324972
51	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.00036924
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.98872698
53	Spliceosome_Homo sapiens_hsa03040	0.96346066
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.91588354
55	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.83301514
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80799912
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.80198776
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80072612
59	Steroid biosynthesis_Homo sapiens_hsa00100	0.79373639
60	Retinol metabolism_Homo sapiens_hsa00830	0.78855440
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78259752
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77667658
63	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.77099330
64	Morphine addiction_Homo sapiens_hsa05032	0.74898344
65	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.72549831
66	Asthma_Homo sapiens_hsa05310	0.70573120
67	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.69981928
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.69470656
69	Circadian rhythm_Homo sapiens_hsa04710	0.68773151
70	Cell cycle_Homo sapiens_hsa04110	0.67136672
71	Metabolic pathways_Homo sapiens_hsa01100	0.66227009
72	GABAergic synapse_Homo sapiens_hsa04727	0.63889635
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60315792
74	p53 signaling pathway_Homo sapiens_hsa04115	0.59963538
75	ABC transporters_Homo sapiens_hsa02010	0.59134432
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59054435
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57294682
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56545706
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.55373288
80	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55318823
81	Fatty acid elongation_Homo sapiens_hsa00062	0.51599397
82	Mineral absorption_Homo sapiens_hsa04978	0.51418926
83	Sulfur relay system_Homo sapiens_hsa04122	0.51359507
84	Basal cell carcinoma_Homo sapiens_hsa05217	0.48317159
85	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.47136447
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.45915210
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45680211
88	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.43349434
89	Serotonergic synapse_Homo sapiens_hsa04726	0.43269546
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41235115
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.40299019
92	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.39630076
93	Circadian entrainment_Homo sapiens_hsa04713	0.37655015
94	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37520100
95	Primary immunodeficiency_Homo sapiens_hsa05340	0.36790976
96	Glutamatergic synapse_Homo sapiens_hsa04724	0.36029793
97	Type I diabetes mellitus_Homo sapiens_hsa04940	0.34811642
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.34744278
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.32922338
100	Oocyte meiosis_Homo sapiens_hsa04114	0.32159229

ZNF567

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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