ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.38867533
2	platelet dense granule organization (GO:0060155)	4.12683849
3	L-fucose metabolic process (GO:0042354)	4.06247064
4	L-fucose catabolic process (GO:0042355)	4.06247064
5	fucose catabolic process (GO:0019317)	4.06247064
6	response to pheromone (GO:0019236)	3.74949591
7	nonmotile primary cilium assembly (GO:0035058)	3.74919405
8	water-soluble vitamin biosynthetic process (GO:0042364)	3.70765138
9	cellular ketone body metabolic process (GO:0046950)	3.59797511
10	protein polyglutamylation (GO:0018095)	3.57627183
11	DNA deamination (GO:0045006)	3.41037962
12	indolalkylamine metabolic process (GO:0006586)	3.40730935
13	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.34130402
14	indole-containing compound catabolic process (GO:0042436)	3.31356002
15	indolalkylamine catabolic process (GO:0046218)	3.31356002
16	tryptophan catabolic process (GO:0006569)	3.31356002
17	ketone body metabolic process (GO:1902224)	3.31221501
18	axoneme assembly (GO:0035082)	3.30638775
19	detection of light stimulus involved in visual perception (GO:0050908)	3.26548559
20	detection of light stimulus involved in sensory perception (GO:0050962)	3.26548559
21	regulation of cilium movement (GO:0003352)	3.20400939
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.19970487
23	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.14365920
24	respiratory chain complex IV assembly (GO:0008535)	3.14347605
25	preassembly of GPI anchor in ER membrane (GO:0016254)	3.11069698
26	kynurenine metabolic process (GO:0070189)	3.10686519
27	regulation of hexokinase activity (GO:1903299)	3.09746578
28	regulation of glucokinase activity (GO:0033131)	3.09746578
29	gamma-aminobutyric acid transport (GO:0015812)	3.07280624
30	tryptophan metabolic process (GO:0006568)	3.06984574
31	epithelial cilium movement (GO:0003351)	3.04990542
32	photoreceptor cell maintenance (GO:0045494)	3.03681443
33	protein localization to cilium (GO:0061512)	3.03368012
34	protein complex biogenesis (GO:0070271)	2.99833487
35	DNA double-strand break processing (GO:0000729)	2.99495588
36	cilium morphogenesis (GO:0060271)	2.98864540
37	protein-cofactor linkage (GO:0018065)	2.91721626
38	cilium organization (GO:0044782)	2.91674715
39	pyrimidine nucleobase catabolic process (GO:0006208)	2.87961513
40	inositol phosphate catabolic process (GO:0071545)	2.85273481
41	cilium assembly (GO:0042384)	2.83708836
42	neural tube formation (GO:0001841)	2.80971999
43	sulfation (GO:0051923)	2.80534399
44	negative regulation of telomere maintenance (GO:0032205)	2.80522838
45	neuronal action potential (GO:0019228)	2.79803690
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.78484215
47	NADH dehydrogenase complex assembly (GO:0010257)	2.78484215
48	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.78484215
49	mitochondrial respiratory chain complex assembly (GO:0033108)	2.75597480
50	cytochrome complex assembly (GO:0017004)	2.75590355
51	kidney morphogenesis (GO:0060993)	2.74943955
52	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.74911673
53	nucleobase catabolic process (GO:0046113)	2.74728037
54	reflex (GO:0060004)	2.71493994
55	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.70337640
56	anterograde synaptic vesicle transport (GO:0048490)	2.69378601
57	signal peptide processing (GO:0006465)	2.68441160
58	regulation of action potential (GO:0098900)	2.67885708
59	intraciliary transport (GO:0042073)	2.67462906
60	retinal cone cell development (GO:0046549)	2.67156405
61	cornea development in camera-type eye (GO:0061303)	2.66289615
62	mannosylation (GO:0097502)	2.62387516
63	indole-containing compound metabolic process (GO:0042430)	2.60131308
64	photoreceptor cell development (GO:0042461)	2.59993263
65	behavioral response to ethanol (GO:0048149)	2.59852280
66	negative regulation of mast cell activation (GO:0033004)	2.58391648
67	cilium movement (GO:0003341)	2.56426693
68	transmission of nerve impulse (GO:0019226)	2.55136711
69	inositol phosphate dephosphorylation (GO:0046855)	2.54876506
70	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.54876506
71	piRNA metabolic process (GO:0034587)	2.54847810
72	glycosphingolipid biosynthetic process (GO:0006688)	2.54459695
73	dopamine transport (GO:0015872)	2.53708852
74	L-methionine salvage (GO:0071267)	2.53594574
75	L-methionine biosynthetic process (GO:0071265)	2.53594574
76	amino acid salvage (GO:0043102)	2.53594574
77	regulation of neurotransmitter uptake (GO:0051580)	2.52714383
78	auditory receptor cell stereocilium organization (GO:0060088)	2.50563946
79	protein K11-linked deubiquitination (GO:0035871)	2.49065109
80	oxidative demethylation (GO:0070989)	2.47290555
81	inner ear receptor stereocilium organization (GO:0060122)	2.47056860
82	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.45914480
83	GPI anchor metabolic process (GO:0006505)	2.45419960
84	presynaptic membrane assembly (GO:0097105)	2.44636587
85	polyol catabolic process (GO:0046174)	2.43759512
86	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.43271800
87	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.43271800
88	C4-dicarboxylate transport (GO:0015740)	2.41730697
89	protein import into peroxisome matrix (GO:0016558)	2.41429011
90	primary amino compound metabolic process (GO:1901160)	2.41288994
91	S-adenosylmethionine metabolic process (GO:0046500)	2.40331428
92	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.38409984
93	eye photoreceptor cell development (GO:0042462)	2.37416432
94	rhodopsin mediated signaling pathway (GO:0016056)	2.35407329
95	peptidyl-histidine modification (GO:0018202)	2.34845849
96	protein prenylation (GO:0018342)	2.34829889
97	prenylation (GO:0097354)	2.34829889
98	cellular biogenic amine catabolic process (GO:0042402)	2.34781505
99	amine catabolic process (GO:0009310)	2.34781505
100	establishment of protein localization to Golgi (GO:0072600)	2.33650422

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.71819273
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.26243414
3	VDR_22108803_ChIP-Seq_LS180_Human	2.84536858
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.76365633
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.75550635
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.65140440
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.63130650
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.47355381
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.36945621
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34533615
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.27535526
12	FUS_26573619_Chip-Seq_HEK293_Human	2.24884022
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.18564126
14	EWS_26573619_Chip-Seq_HEK293_Human	2.18057948
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.14847732
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.14338962
17	P300_19829295_ChIP-Seq_ESCs_Human	2.10074707
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.08903072
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.99486756
20	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.96241888
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.84120880
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.79757013
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.79282911
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.77909049
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.67375375
26	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.66813473
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.59746037
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59520640
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.57535135
30	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.57298980
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.57266990
32	STAT3_23295773_ChIP-Seq_U87_Human	1.55903630
33	* CBP_20019798_ChIP-Seq_JUKART_Human	1.55656627
34	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55656627
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54850150
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54114027
37	* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.53542152
38	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53064314
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46298166
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.45984546
41	AR_25329375_ChIP-Seq_VCAP_Human	1.45837741
42	TCF4_23295773_ChIP-Seq_U87_Human	1.45231230
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45090300
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43912893
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43451094
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.43385646
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41136264
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39112356
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38666029
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.38621700
51	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.37430040
52	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.36750768
53	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.35004436
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34563286
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34082450
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33502121
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33502121
58	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.32637540
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.29386128
60	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.29002709
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28751689
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.27285656
63	ELK1_19687146_ChIP-ChIP_HELA_Human	1.27114671
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27045052
65	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25479196
66	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24191825
67	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23871832
68	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.21494777
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21103674
70	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21074722
71	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.21000336
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20566345
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20566345
74	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.20561281
75	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.19923202
76	MYC_18940864_ChIP-ChIP_HL60_Human	1.19320926
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.18566053
78	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17116390
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16880033
80	P53_22387025_ChIP-Seq_ESCs_Mouse	1.16411493
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13774981
82	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13470456
83	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.13470456
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12050729
85	AR_20517297_ChIP-Seq_VCAP_Human	1.09438374
86	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.07366942
87	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.06381358
88	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.06173269
89	NCOR_22424771_ChIP-Seq_293T_Human	1.05879426
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05516633
91	* VDR_23849224_ChIP-Seq_CD4+_Human	1.05464284
92	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.02188953
93	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.01915485
94	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.01157789
95	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.00955095
96	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00131263
97	CDX2_22108803_ChIP-Seq_LS180_Human	1.00067283
98	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.99440888
99	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.99372832
100	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99006978

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	2.86636695
2	MP0008877_abnormal_DNA_methylation	2.61985122
3	MP0002837_dystrophic_cardiac_calcinosis	2.57557158
4	MP0006072_abnormal_retinal_apoptosis	2.54845925
5	MP0000569_abnormal_digit_pigmentation	2.52551111
6	MP0003195_calcinosis	2.47117532
7	MP0005551_abnormal_eye_electrophysiolog	2.41509215
8	MP0001968_abnormal_touch/_nociception	2.39126269
9	MP0001984_abnormal_olfaction	2.23850653
10	MP0005253_abnormal_eye_physiology	2.17441759
11	MP0002736_abnormal_nociception_after	2.12416359
12	MP0009046_muscle_twitch	2.04103202
13	MP0002638_abnormal_pupillary_reflex	1.98890465
14	MP0005646_abnormal_pituitary_gland	1.98465014
15	MP0000372_irregular_coat_pigmentation	1.96656544
16	MP0005645_abnormal_hypothalamus_physiol	1.92925090
17	MP0009745_abnormal_behavioral_response	1.91807297
18	MP0004142_abnormal_muscle_tone	1.91426918
19	MP0003787_abnormal_imprinting	1.91062290
20	MP0003646_muscle_fatigue	1.84887573
21	MP0003880_abnormal_central_pattern	1.84238095
22	MP0006276_abnormal_autonomic_nervous	1.79077977
23	MP0006292_abnormal_olfactory_placode	1.74503312
24	MP0004885_abnormal_endolymph	1.73366773
25	MP0002876_abnormal_thyroid_physiology	1.73316267
26	MP0002653_abnormal_ependyma_morphology	1.69742889
27	MP0001529_abnormal_vocalization	1.69454479
28	MP0005379_endocrine/exocrine_gland_phen	1.69307109
29	MP0000631_abnormal_neuroendocrine_gland	1.66867856
30	MP0002272_abnormal_nervous_system	1.65576396
31	MP0003011_delayed_dark_adaptation	1.64142161
32	MP0000427_abnormal_hair_cycle	1.61608711
33	MP0002909_abnormal_adrenal_gland	1.57225308
34	MP0008872_abnormal_physiological_respon	1.56838841
35	MP0004043_abnormal_pH_regulation	1.55678765
36	MP0004147_increased_porphyrin_level	1.53664064
37	MP0002938_white_spotting	1.53467129
38	MP0001501_abnormal_sleep_pattern	1.52254126
39	MP0001986_abnormal_taste_sensitivity	1.51245411
40	MP0002163_abnormal_gland_morphology	1.50588446
41	MP0008789_abnormal_olfactory_epithelium	1.49189429
42	MP0001486_abnormal_startle_reflex	1.45445377
43	MP0002928_abnormal_bile_duct	1.36621215
44	MP0008875_abnormal_xenobiotic_pharmacok	1.36120546
45	MP0005084_abnormal_gallbladder_morpholo	1.34949291
46	MP0002557_abnormal_social/conspecific_i	1.34115288
47	MP0002572_abnormal_emotion/affect_behav	1.31379648
48	MP0002064_seizures	1.28923595
49	MP0005174_abnormal_tail_pigmentation	1.28430821
50	MP0001485_abnormal_pinna_reflex	1.26885006
51	MP0003122_maternal_imprinting	1.22178058
52	MP0004133_heterotaxia	1.20789674
53	MP0003136_yellow_coat_color	1.20291864
54	MP0002234_abnormal_pharynx_morphology	1.19026728
55	MP0010386_abnormal_urinary_bladder	1.18069794
56	MP0002734_abnormal_mechanical_nocicepti	1.12869871
57	MP0004924_abnormal_behavior	1.12793666
58	MP0005386_behavior/neurological_phenoty	1.12793666
59	MP0001970_abnormal_pain_threshold	1.11802534
60	MP0003121_genomic_imprinting	1.11670365
61	MP0005075_abnormal_melanosome_morpholog	1.11024625
62	MP0004145_abnormal_muscle_electrophysio	1.10522498
63	MP0001905_abnormal_dopamine_level	1.09859087
64	MP0004215_abnormal_myocardial_fiber	1.05642641
65	MP0002735_abnormal_chemical_nociception	1.04729001
66	MP0002751_abnormal_autonomic_nervous	1.04003063
67	MP0005394_taste/olfaction_phenotype	1.03581676
68	MP0005499_abnormal_olfactory_system	1.03581676
69	MP0003635_abnormal_synaptic_transmissio	1.02682504
70	MP0000383_abnormal_hair_follicle	1.02362135
71	MP0002733_abnormal_thermal_nociception	0.99558039
72	MP0002067_abnormal_sensory_capabilities	0.98946556
73	MP0005195_abnormal_posterior_eye	0.98782275
74	MP0002063_abnormal_learning/memory/cond	0.98584009
75	MP0002160_abnormal_reproductive_system	0.96303165
76	MP0005389_reproductive_system_phenotype	0.95878648
77	MP0003137_abnormal_impulse_conducting	0.95554372
78	MP0001764_abnormal_homeostasis	0.94118567
79	MP0002095_abnormal_skin_pigmentation	0.94105300
80	MP0004742_abnormal_vestibular_system	0.92164863
81	MP0001502_abnormal_circadian_rhythm	0.91831995
82	MP0004270_analgesia	0.90014921
83	MP0000647_abnormal_sebaceous_gland	0.89698685
84	MP0000778_abnormal_nervous_system	0.89598274
85	MP0009780_abnormal_chondrocyte_physiolo	0.88983363
86	MP0002184_abnormal_innervation	0.87761085
87	MP0001324_abnormal_eye_pigmentation	0.87393046
88	MP0000026_abnormal_inner_ear	0.86887759
89	MP0005187_abnormal_penis_morphology	0.86811853
90	MP0002752_abnormal_somatic_nervous	0.86356098
91	MP0003718_maternal_effect	0.86133056
92	MP0002693_abnormal_pancreas_physiology	0.85182767
93	MP0000230_abnormal_systemic_arterial	0.85145232
94	MP0001963_abnormal_hearing_physiology	0.84431068
95	MP0008995_early_reproductive_senescence	0.83199588
96	MP0004085_abnormal_heartbeat	0.82605763
97	MP0005391_vision/eye_phenotype	0.82374855
98	MP0005367_renal/urinary_system_phenotyp	0.82050259
99	MP0000516_abnormal_urinary_system	0.82050259
100	MP0005171_absent_coat_pigmentation	0.81807471

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.42254701
2	Pancreatic fibrosis (HP:0100732)	4.07781331
3	Molar tooth sign on MRI (HP:0002419)	3.99415789
4	Abnormality of midbrain morphology (HP:0002418)	3.99415789
5	Medial flaring of the eyebrow (HP:0010747)	3.89635112
6	True hermaphroditism (HP:0010459)	3.76131021
7	Nephronophthisis (HP:0000090)	3.46930604
8	Congenital stationary night blindness (HP:0007642)	3.39638174
9	Gait imbalance (HP:0002141)	3.37345638
10	Congenital primary aphakia (HP:0007707)	3.31448103
11	Abnormality of the renal cortex (HP:0011035)	3.14932388
12	Abnormality of the renal medulla (HP:0100957)	3.07533572
13	Nephrogenic diabetes insipidus (HP:0009806)	3.01368231
14	Hypothermia (HP:0002045)	2.95996644
15	Abolished electroretinogram (ERG) (HP:0000550)	2.92334214
16	Hyperventilation (HP:0002883)	2.87108596
17	Attenuation of retinal blood vessels (HP:0007843)	2.85764781
18	Genital tract atresia (HP:0001827)	2.80288859
19	Type II lissencephaly (HP:0007260)	2.75979133
20	Hemiparesis (HP:0001269)	2.67699665
21	Vaginal atresia (HP:0000148)	2.64338809
22	Chronic hepatic failure (HP:0100626)	2.61781666
23	Acute necrotizing encephalopathy (HP:0006965)	2.55864326
24	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.51821370
25	Cystic liver disease (HP:0006706)	2.49886516
26	Progressive macrocephaly (HP:0004481)	2.46564175
27	Large for gestational age (HP:0001520)	2.41348298
28	Increased corneal curvature (HP:0100692)	2.40864436
29	Keratoconus (HP:0000563)	2.40864436
30	Increased CSF lactate (HP:0002490)	2.40232338
31	Renal cortical cysts (HP:0000803)	2.38783660
32	Abnormality of alanine metabolism (HP:0010916)	2.36256173
33	Hyperalaninemia (HP:0003348)	2.36256173
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.36256173
35	Mitochondrial inheritance (HP:0001427)	2.34384391
36	Poor coordination (HP:0002370)	2.33597932
37	Gaze-evoked nystagmus (HP:0000640)	2.31466291
38	Tubular atrophy (HP:0000092)	2.29608045
39	Colon cancer (HP:0003003)	2.28965777
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.27592821
41	Methylmalonic acidemia (HP:0002912)	2.26248814
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.26019055
43	3-Methylglutaconic aciduria (HP:0003535)	2.25916256
44	Sclerocornea (HP:0000647)	2.24925364
45	Pendular nystagmus (HP:0012043)	2.24575198
46	Polydipsia (HP:0001959)	2.21306122
47	Abnormal drinking behavior (HP:0030082)	2.21306122
48	Inability to walk (HP:0002540)	2.21243212
49	Acute encephalopathy (HP:0006846)	2.19415278
50	Progressive inability to walk (HP:0002505)	2.18862266
51	Broad-based gait (HP:0002136)	2.18256421
52	Bony spicule pigmentary retinopathy (HP:0007737)	2.17630489
53	Decreased central vision (HP:0007663)	2.13036137
54	Short tibia (HP:0005736)	2.12216063
55	Abnormal mitochondria in muscle tissue (HP:0008316)	2.10062416
56	Intestinal atresia (HP:0011100)	2.08661844
57	Hepatocellular necrosis (HP:0001404)	2.07742232
58	Furrowed tongue (HP:0000221)	2.07453120
59	Postaxial hand polydactyly (HP:0001162)	2.06121577
60	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.06017396
61	Absent speech (HP:0001344)	2.04779071
62	Hepatic necrosis (HP:0002605)	2.03683216
63	Chorioretinal atrophy (HP:0000533)	2.03102342
64	Lissencephaly (HP:0001339)	2.00718765
65	Anencephaly (HP:0002323)	1.99441061
66	Ketoacidosis (HP:0001993)	1.98733133
67	Postaxial foot polydactyly (HP:0001830)	1.97968549
68	Cerebellar dysplasia (HP:0007033)	1.97893301
69	Congenital hepatic fibrosis (HP:0002612)	1.97848452
70	Abnormality of the labia minora (HP:0012880)	1.96232439
71	Febrile seizures (HP:0002373)	1.95890741
72	Aplasia/hypoplasia of the uterus (HP:0008684)	1.95808084
73	Abnormal biliary tract physiology (HP:0012439)	1.94554353
74	Bile duct proliferation (HP:0001408)	1.94554353
75	Progressive cerebellar ataxia (HP:0002073)	1.94553110
76	Pachygyria (HP:0001302)	1.93459094
77	Methylmalonic aciduria (HP:0012120)	1.93073693
78	Absent/shortened dynein arms (HP:0200106)	1.90783331
79	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.90783331
80	Specific learning disability (HP:0001328)	1.90539186
81	Optic disc pallor (HP:0000543)	1.88198822
82	Male pseudohermaphroditism (HP:0000037)	1.87222719
83	Retinitis pigmentosa (HP:0000510)	1.85712678
84	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.85097839
85	Hypoplasia of the fovea (HP:0007750)	1.85097839
86	Thyroid-stimulating hormone excess (HP:0002925)	1.84737710
87	Ketosis (HP:0001946)	1.84611587
88	Optic nerve hypoplasia (HP:0000609)	1.79563722
89	Severe muscular hypotonia (HP:0006829)	1.78109575
90	Broad foot (HP:0001769)	1.76649605
91	Congenital, generalized hypertrichosis (HP:0004540)	1.75530618
92	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.75390094
93	Polyuria (HP:0000103)	1.74510337
94	Astigmatism (HP:0000483)	1.74283217
95	Neoplasm of the adrenal cortex (HP:0100641)	1.73947159
96	Stomach cancer (HP:0012126)	1.72720907
97	Polyphagia (HP:0002591)	1.72075365
98	Focal motor seizures (HP:0011153)	1.71139936
99	Focal seizures (HP:0007359)	1.70853296
100	Thyroiditis (HP:0100646)	1.70712264

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.96470529
2	MAP4K2	3.62609981
3	BMPR1B	2.91825803
4	WNK3	2.67970321
5	ADRBK2	2.50593609
6	PINK1	2.42349810
7	CASK	2.40973134
8	NUAK1	2.39685970
9	GRK1	2.25490034
10	TRIM28	2.13923592
11	ZAK	2.12769214
12	MAP3K4	1.90188324
13	MAPK13	1.81508809
14	TNIK	1.68047806
15	INSRR	1.63949034
16	BCR	1.59055334
17	ACVR1B	1.58948353
18	TAOK3	1.47760049
19	OXSR1	1.43346755
20	PLK2	1.36542853
21	PAK3	1.36475899
22	WNK4	1.28884358
23	TLK1	1.26422035
24	MARK1	1.25590801
25	ERBB3	1.21729105
26	MAP2K7	1.20744559
27	PRKCE	1.20608745
28	TAF1	1.18754992
29	STK39	1.18463009
30	MKNK2	1.18421227
31	DAPK2	1.17844649
32	FGFR2	1.17394360
33	CSNK1G2	1.15396963
34	CSNK1G1	1.14614785
35	CSNK1G3	1.12343837
36	PHKG2	1.11469293
37	PHKG1	1.11469293
38	VRK1	1.08764859
39	MST4	1.07183283
40	TXK	1.06171940
41	STK38L	1.04979259
42	PNCK	1.03152286
43	DYRK2	1.00435175
44	VRK2	0.97237804
45	PRKCG	0.96613130
46	CSNK1A1L	0.96245603
47	EIF2AK3	0.91973007
48	TGFBR1	0.84750287
49	ADRBK1	0.82408229
50	MUSK	0.81466000
51	EPHA3	0.80749387
52	BCKDK	0.80194120
53	NTRK3	0.79702140
54	PLK3	0.77293718
55	MAP2K6	0.75078129
56	TIE1	0.72298903
57	NLK	0.70114155
58	OBSCN	0.69948683
59	NME1	0.69576613
60	FER	0.69494978
61	BRSK2	0.69264746
62	FLT3	0.64531291
63	NTRK2	0.62854811
64	CAMK2A	0.59536317
65	EPHA4	0.58599423
66	PIK3CA	0.57964165
67	CAMKK2	0.57401075
68	PTK2B	0.57002336
69	MAPKAPK3	0.55076202
70	MAP3K12	0.50571085
71	STK11	0.49797040
72	TSSK6	0.48948713
73	MKNK1	0.48013883
74	CSNK1A1	0.46913577
75	PRKD3	0.45783783
76	PRKACA	0.45497602
77	RPS6KA5	0.45249499
78	AKT3	0.44228667
79	WEE1	0.43813376
80	PKN1	0.43692908
81	PASK	0.41632358
82	STK3	0.39449751
83	TEC	0.39069771
84	PLK4	0.38596037
85	PRKCI	0.37002721
86	MAPKAPK5	0.36884162
87	PRKAA1	0.36043239
88	MAP2K4	0.34958470
89	CSNK1D	0.34647654
90	PRKG1	0.33697115
91	PIK3CG	0.32241515
92	CDK3	0.32221057
93	PRKCQ	0.32040198
94	IRAK1	0.31796990
95	DYRK1A	0.31543523
96	IKBKB	0.30809165
97	PRKAA2	0.29493625
98	CCNB1	0.29465216
99	PLK1	0.28746731
100	GRK5	0.28337633

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.85591493
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.78419011
3	Butanoate metabolism_Homo sapiens_hsa00650	2.76658072
4	Phototransduction_Homo sapiens_hsa04744	2.59919372
5	Protein export_Homo sapiens_hsa03060	2.59587239
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.54064212
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.42780343
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.37932593
9	Nicotine addiction_Homo sapiens_hsa05033	2.11445977
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.08919540
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.00842815
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.95432048
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.86575882
14	RNA polymerase_Homo sapiens_hsa03020	1.83862502
15	Parkinsons disease_Homo sapiens_hsa05012	1.81841056
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.81587884
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.80945787
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.76542177
19	Propanoate metabolism_Homo sapiens_hsa00640	1.73952785
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.71653942
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.71163630
22	Basal transcription factors_Homo sapiens_hsa03022	1.54045089
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.53860956
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.50782437
25	Caffeine metabolism_Homo sapiens_hsa00232	1.48411926
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.46730400
27	Peroxisome_Homo sapiens_hsa04146	1.45028717
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.40675725
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39511684
30	Taste transduction_Homo sapiens_hsa04742	1.36880166
31	Olfactory transduction_Homo sapiens_hsa04740	1.36789804
32	Regulation of autophagy_Homo sapiens_hsa04140	1.36556956
33	Homologous recombination_Homo sapiens_hsa03440	1.35620740
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.32098690
35	Insulin secretion_Homo sapiens_hsa04911	1.29149513
36	RNA degradation_Homo sapiens_hsa03018	1.29138530
37	GABAergic synapse_Homo sapiens_hsa04727	1.21985278
38	Morphine addiction_Homo sapiens_hsa05032	1.21137318
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.19082295
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.18857800
41	Huntingtons disease_Homo sapiens_hsa05016	1.18710551
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.18668709
43	beta-Alanine metabolism_Homo sapiens_hsa00410	1.17375635
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.16566242
45	Alzheimers disease_Homo sapiens_hsa05010	1.12672055
46	Cardiac muscle contraction_Homo sapiens_hsa04260	1.12381160
47	Circadian entrainment_Homo sapiens_hsa04713	1.11353936
48	ABC transporters_Homo sapiens_hsa02010	1.08763310
49	Chemical carcinogenesis_Homo sapiens_hsa05204	1.08267302
50	One carbon pool by folate_Homo sapiens_hsa00670	1.06984656
51	Retinol metabolism_Homo sapiens_hsa00830	1.01850294
52	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.97593255
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.89976861
54	Circadian rhythm_Homo sapiens_hsa04710	0.88294522
55	Serotonergic synapse_Homo sapiens_hsa04726	0.84164280
56	Sulfur metabolism_Homo sapiens_hsa00920	0.83286883
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.82637433
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82334610
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82290680
60	Purine metabolism_Homo sapiens_hsa00230	0.80489580
61	Proteasome_Homo sapiens_hsa03050	0.73663237
62	Dopaminergic synapse_Homo sapiens_hsa04728	0.68951973
63	Metabolic pathways_Homo sapiens_hsa01100	0.68926607
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67755153
65	Salivary secretion_Homo sapiens_hsa04970	0.66454048
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.64342783
67	Type I diabetes mellitus_Homo sapiens_hsa04940	0.62517298
68	Fatty acid elongation_Homo sapiens_hsa00062	0.62091746
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61040769
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60011659
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57875640
72	Fatty acid degradation_Homo sapiens_hsa00071	0.57627894
73	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.57250175
74	Amphetamine addiction_Homo sapiens_hsa05031	0.56011506
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.55683450
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.55647164
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55228048
78	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.53447287
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.52952502
80	Mineral absorption_Homo sapiens_hsa04978	0.52099684
81	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51356802
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50281256
83	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.50222835
84	Non-homologous end-joining_Homo sapiens_hsa03450	0.49592236
85	Fatty acid metabolism_Homo sapiens_hsa01212	0.47434338
86	Histidine metabolism_Homo sapiens_hsa00340	0.47367908
87	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.45994481
88	Renin secretion_Homo sapiens_hsa04924	0.44084567
89	Folate biosynthesis_Homo sapiens_hsa00790	0.43483110
90	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.43254698
91	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.42887532
92	Cocaine addiction_Homo sapiens_hsa05030	0.42501776
93	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.40609613
94	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.39253072
95	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.37349331
96	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.35415807
97	Pyrimidine metabolism_Homo sapiens_hsa00240	0.35260391
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.33549213
99	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.31302423
100	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.27503936

ZNF568

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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