ZNF569

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.20184935
2piRNA metabolic process (GO:0034587)4.07423251
3intraciliary transport (GO:0042073)4.00457380
4neural tube formation (GO:0001841)3.68534979
5histone H2A acetylation (GO:0043968)3.61656173
6pyrimidine nucleobase catabolic process (GO:0006208)3.58981131
7DNA damage response, detection of DNA damage (GO:0042769)3.51250560
8regulation of meiosis I (GO:0060631)3.47430840
9chromatin remodeling at centromere (GO:0031055)3.44733622
10centriole replication (GO:0007099)3.44224453
11protein localization to cilium (GO:0061512)3.37519243
12resolution of meiotic recombination intermediates (GO:0000712)3.35716853
13positive regulation of mitochondrial fission (GO:0090141)3.30036837
14cullin deneddylation (GO:0010388)3.28551025
15CENP-A containing nucleosome assembly (GO:0034080)3.26995865
16microtubule depolymerization (GO:0007019)3.13679390
17somite development (GO:0061053)3.09427920
18DNA methylation involved in gamete generation (GO:0043046)3.07851846
19somatic hypermutation of immunoglobulin genes (GO:0016446)3.07570698
20somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07570698
21regulation of helicase activity (GO:0051095)3.07522966
22negative regulation of DNA recombination (GO:0045910)3.03090516
23positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.96904568
24positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.96904568
25positive regulation of mitotic sister chromatid separation (GO:1901970)2.96904568
26histone mRNA metabolic process (GO:0008334)2.96765725
27microtubule anchoring (GO:0034453)2.94532907
28acrosome reaction (GO:0007340)2.91298468
29response to pheromone (GO:0019236)2.91033149
30DNA replication-dependent nucleosome assembly (GO:0006335)2.90297526
31DNA replication-dependent nucleosome organization (GO:0034723)2.90297526
32protein deneddylation (GO:0000338)2.89270249
33histone exchange (GO:0043486)2.87440103
34postreplication repair (GO:0006301)2.84074689
35meiotic chromosome segregation (GO:0045132)2.83346204
36nonmotile primary cilium assembly (GO:0035058)2.83224758
37attachment of spindle microtubules to kinetochore (GO:0008608)2.80897131
38synapsis (GO:0007129)2.80557556
39L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.78127755
40negative regulation of transcription regulatory region DNA binding (GO:2000678)2.77452517
41regulation of DNA endoreduplication (GO:0032875)2.77090268
42cilium assembly (GO:0042384)2.75772084
43regulation of mitotic spindle checkpoint (GO:1903504)2.74218182
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74218182
45cilium organization (GO:0044782)2.71212071
46nucleobase catabolic process (GO:0046113)2.69776725
47replication fork processing (GO:0031297)2.69563585
48recombinational repair (GO:0000725)2.67938392
49negative regulation of DNA-dependent DNA replication (GO:2000104)2.66456655
50regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.64616078
51double-strand break repair via homologous recombination (GO:0000724)2.64318461
52DNA replication-independent nucleosome assembly (GO:0006336)2.63465836
53DNA replication-independent nucleosome organization (GO:0034724)2.63465836
54regulation of telomere maintenance (GO:0032204)2.62075085
55cilium morphogenesis (GO:0060271)2.61949853
56limb bud formation (GO:0060174)2.61732780
57spermatid nucleus differentiation (GO:0007289)2.61521150
58microtubule polymerization or depolymerization (GO:0031109)2.60834591
59behavioral response to nicotine (GO:0035095)2.59446622
60spindle checkpoint (GO:0031577)2.57934995
61cell fate commitment involved in formation of primary germ layer (GO:0060795)2.57319250
62mitotic spindle checkpoint (GO:0071174)2.57223245
63reciprocal meiotic recombination (GO:0007131)2.57086025
64reciprocal DNA recombination (GO:0035825)2.57086025
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.56311963
66olfactory bulb development (GO:0021772)2.54595091
67protein-cofactor linkage (GO:0018065)2.54576068
68regulation of mitotic sister chromatid separation (GO:0010965)2.54197391
69regulation of mitotic sister chromatid segregation (GO:0033047)2.54197391
70regulation of sister chromatid segregation (GO:0033045)2.54197391
71DNA integration (GO:0015074)2.54124243
72gene silencing by RNA (GO:0031047)2.53468416
73double-strand break repair via nonhomologous end joining (GO:0006303)2.50464692
74non-recombinational repair (GO:0000726)2.50464692
75regulation of mitotic metaphase/anaphase transition (GO:0030071)2.48502273
76regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.48502273
77negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.47231385
78negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.47231385
79negative regulation of mitotic sister chromatid segregation (GO:0033048)2.47231385
80negative regulation of mitotic sister chromatid separation (GO:2000816)2.47231385
81negative regulation of sister chromatid segregation (GO:0033046)2.47231385
82regulation of nuclear cell cycle DNA replication (GO:0033262)2.46773418
83protein K11-linked ubiquitination (GO:0070979)2.46603700
84regulation of cilium movement (GO:0003352)2.46403475
85DNA catabolic process, exonucleolytic (GO:0000738)2.46150971
86protein localization to chromosome (GO:0034502)2.46122834
87epithelial cilium movement (GO:0003351)2.45858633
88spindle assembly checkpoint (GO:0071173)2.44438139
89negative regulation of chromosome segregation (GO:0051985)2.43712415
90mitotic spindle assembly checkpoint (GO:0007094)2.42614963
91regulation of double-strand break repair via homologous recombination (GO:0010569)2.42600645
92ribonucleoprotein complex disassembly (GO:0032988)2.42217963
93meiotic cell cycle (GO:0051321)2.40573223
94head development (GO:0060322)2.40350752
95mitotic metaphase plate congression (GO:0007080)2.39803208
96histone H2A ubiquitination (GO:0033522)2.38846916
97intra-S DNA damage checkpoint (GO:0031573)2.38410401
98pyrimidine dimer repair (GO:0006290)2.38377362
99regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.38078859
100protein localization to kinetochore (GO:0034501)2.37400786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human3.58491343
2ZNF274_21170338_ChIP-Seq_K562_Hela3.27610709
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.83790295
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.78398881
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.73250119
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.49482867
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44234153
8* EST1_17652178_ChIP-ChIP_JURKAT_Human2.39490130
9EWS_26573619_Chip-Seq_HEK293_Human2.39360714
10FUS_26573619_Chip-Seq_HEK293_Human2.38408568
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37833786
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37477071
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29116809
14ELK1_19687146_ChIP-ChIP_HELA_Human2.28110037
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27333660
16TAF15_26573619_Chip-Seq_HEK293_Human2.20664195
17E2F7_22180533_ChIP-Seq_HELA_Human2.20470561
18VDR_22108803_ChIP-Seq_LS180_Human2.14596968
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12468429
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10653607
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09113354
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.07124116
23GBX2_23144817_ChIP-Seq_PC3_Human2.06186930
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01087064
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00948786
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97237504
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81938447
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80280487
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.80212804
30P300_19829295_ChIP-Seq_ESCs_Human1.78848845
31* VDR_23849224_ChIP-Seq_CD4+_Human1.77528046
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76204995
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76006001
34IRF1_19129219_ChIP-ChIP_H3396_Human1.66056472
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64995846
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61526479
37MYC_18940864_ChIP-ChIP_HL60_Human1.60368343
38* ETS1_20019798_ChIP-Seq_JURKAT_Human1.53050973
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50604297
40EZH2_22144423_ChIP-Seq_EOC_Human1.48748984
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48296790
42* FOXP3_21729870_ChIP-Seq_TREG_Human1.46415130
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45945999
44CBP_20019798_ChIP-Seq_JUKART_Human1.45945999
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43878650
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43867167
47ER_23166858_ChIP-Seq_MCF-7_Human1.42595253
48RNF2_27304074_Chip-Seq_NSC_Mouse1.42534619
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40439954
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39912725
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39678509
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.36908880
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35038188
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33831370
55* NOTCH1_21737748_ChIP-Seq_TLL_Human1.33116951
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31024271
57SMAD4_21799915_ChIP-Seq_A2780_Human1.30529103
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26748101
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25959411
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25684106
61* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25029094
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24141053
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.23698077
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21835030
65FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21538721
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21206755
67STAT3_23295773_ChIP-Seq_U87_Human1.19140086
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.17514308
69TP53_22573176_ChIP-Seq_HFKS_Human1.15353910
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.13190714
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11775634
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.11278723
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10629281
74AR_25329375_ChIP-Seq_VCAP_Human1.10492523
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10211711
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09360278
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09117367
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07882619
79* RUNX2_22187159_ChIP-Seq_PCA_Human1.07459506
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06743153
81TCF4_23295773_ChIP-Seq_U87_Human1.06320202
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.05409482
83* GABP_19822575_ChIP-Seq_HepG2_Human1.04845358
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03728276
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02937771
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02816490
87DCP1A_22483619_ChIP-Seq_HELA_Human1.02769589
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01210742
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01210742
90* SOX2_16153702_ChIP-ChIP_HESCs_Human1.01169494
91THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01037360
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00422029
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.00362595
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99992552
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99529017
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99494407
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97088450
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.96747271
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95404287
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.95047248

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.83969057
2MP0003880_abnormal_central_pattern3.31069844
3MP0002102_abnormal_ear_morphology3.26991059
4MP0008058_abnormal_DNA_repair3.04608753
5MP0003787_abnormal_imprinting2.94512414
6MP0008057_abnormal_DNA_replication2.73772717
7MP0006292_abnormal_olfactory_placode2.67003597
8MP0008789_abnormal_olfactory_epithelium2.57698974
9MP0003121_genomic_imprinting2.48692325
10MP0010094_abnormal_chromosome_stability2.39639363
11MP0005394_taste/olfaction_phenotype2.37539903
12MP0005499_abnormal_olfactory_system2.37539903
13MP0001529_abnormal_vocalization2.28007178
14MP0001984_abnormal_olfaction2.04866154
15MP0000778_abnormal_nervous_system1.97396502
16MP0003718_maternal_effect1.82820589
17MP0002234_abnormal_pharynx_morphology1.77548049
18MP0009046_muscle_twitch1.75185696
19MP0006072_abnormal_retinal_apoptosis1.73487967
20MP0006276_abnormal_autonomic_nervous1.73347573
21MP0001188_hyperpigmentation1.71894086
22MP0009697_abnormal_copulation1.69918580
23MP0002653_abnormal_ependyma_morphology1.65202493
24MP0003122_maternal_imprinting1.58472738
25MP0000049_abnormal_middle_ear1.56281487
26MP0003221_abnormal_cardiomyocyte_apopto1.54948862
27MP0005253_abnormal_eye_physiology1.49396310
28MP0002751_abnormal_autonomic_nervous1.43259074
29MP0005645_abnormal_hypothalamus_physiol1.42802848
30MP0008932_abnormal_embryonic_tissue1.40178123
31MP0004133_heterotaxia1.39734665
32MP0003693_abnormal_embryo_hatching1.38614655
33MP0005551_abnormal_eye_electrophysiolog1.37703919
34MP0001293_anophthalmia1.34885891
35MP0001929_abnormal_gametogenesis1.32172827
36MP0002210_abnormal_sex_determination1.29576163
37MP0003077_abnormal_cell_cycle1.27355467
38MP0003937_abnormal_limbs/digits/tail_de1.26153466
39MP0002233_abnormal_nose_morphology1.25508522
40MP0002272_abnormal_nervous_system1.24833108
41MP0003567_abnormal_fetal_cardiomyocyte1.23815645
42MP0000647_abnormal_sebaceous_gland1.23568879
43MP0000631_abnormal_neuroendocrine_gland1.23184207
44MP0008995_early_reproductive_senescence1.22516137
45MP0003698_abnormal_male_reproductive1.22158023
46MP0002184_abnormal_innervation1.19719372
47MP0003119_abnormal_digestive_system1.19617631
48MP0006035_abnormal_mitochondrial_morpho1.18813137
49MP0002837_dystrophic_cardiac_calcinosis1.18109428
50MP0003111_abnormal_nucleus_morphology1.17920286
51MP0003890_abnormal_embryonic-extraembry1.15553779
52MP0000955_abnormal_spinal_cord1.12622156
53MP0009745_abnormal_behavioral_response1.12387221
54MP0001145_abnormal_male_reproductive1.11083948
55MP0000653_abnormal_sex_gland1.11078735
56MP0001486_abnormal_startle_reflex1.10073448
57MP0004957_abnormal_blastocyst_morpholog1.09641176
58MP0001764_abnormal_homeostasis1.06841083
59MP0005187_abnormal_penis_morphology1.05859355
60MP0001485_abnormal_pinna_reflex1.05275594
61MP0000516_abnormal_urinary_system1.04793661
62MP0005367_renal/urinary_system_phenotyp1.04793661
63MP0004885_abnormal_endolymph1.04446544
64MP0003861_abnormal_nervous_system1.02356752
65MP0000427_abnormal_hair_cycle1.01371347
66MP0004215_abnormal_myocardial_fiber1.01320706
67MP0002736_abnormal_nociception_after1.01145859
68MP0004142_abnormal_muscle_tone0.99524311
69MP0008007_abnormal_cellular_replicative0.99387576
70MP0001177_atelectasis0.99261456
71MP0001286_abnormal_eye_development0.98877423
72MP0002752_abnormal_somatic_nervous0.97687600
73MP0005248_abnormal_Harderian_gland0.97642771
74MP0003786_premature_aging0.96537874
75MP0003755_abnormal_palate_morphology0.95490753
76MP0005084_abnormal_gallbladder_morpholo0.95314333
77MP0000569_abnormal_digit_pigmentation0.94964761
78MP0004811_abnormal_neuron_physiology0.93900389
79MP0003635_abnormal_synaptic_transmissio0.92698132
80MP0004147_increased_porphyrin_level0.91946615
81MP0005391_vision/eye_phenotype0.90257337
82MP0002572_abnormal_emotion/affect_behav0.89730763
83MP0002160_abnormal_reproductive_system0.89481222
84MP0002938_white_spotting0.87140683
85MP0002063_abnormal_learning/memory/cond0.87114739
86MP0002882_abnormal_neuron_morphology0.85726588
87MP0002084_abnormal_developmental_patter0.85566444
88MP0002152_abnormal_brain_morphology0.85027570
89MP0009703_decreased_birth_body0.84969377
90MP0002557_abnormal_social/conspecific_i0.84077888
91MP0005423_abnormal_somatic_nervous0.81948984
92MP0004197_abnormal_fetal_growth/weight/0.81948722
93MP0001968_abnormal_touch/_nociception0.81655991
94MP0004270_analgesia0.81516534
95MP0002067_abnormal_sensory_capabilities0.80662924
96MP0003938_abnormal_ear_development0.80323183
97MP0001299_abnormal_eye_distance/0.80303432
98MP0002009_preneoplasia0.79997386
99MP0003136_yellow_coat_color0.79031555
100MP0003385_abnormal_body_wall0.78867570

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.58471990
2Medial flaring of the eyebrow (HP:0010747)3.58192297
3Gait imbalance (HP:0002141)3.49359874
4Abnormality of the labia minora (HP:0012880)3.41941173
5Congenital primary aphakia (HP:0007707)3.41904628
6Nephrogenic diabetes insipidus (HP:0009806)3.18457375
7Intestinal atresia (HP:0011100)3.16926617
8Nephronophthisis (HP:0000090)2.95211869
9Abnormality of midbrain morphology (HP:0002418)2.93129142
10Molar tooth sign on MRI (HP:0002419)2.93129142
11Pancreatic cysts (HP:0001737)2.88273417
12Septo-optic dysplasia (HP:0100842)2.86803161
13Genital tract atresia (HP:0001827)2.83187331
14Vaginal atresia (HP:0000148)2.80359617
15True hermaphroditism (HP:0010459)2.65009387
16Pancreatic fibrosis (HP:0100732)2.61102056
17Meckel diverticulum (HP:0002245)2.53136278
18Shoulder girdle muscle weakness (HP:0003547)2.52388103
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.51808765
20Tubulointerstitial nephritis (HP:0001970)2.50932712
21Amyotrophic lateral sclerosis (HP:0007354)2.49721021
22Abnormality of the ileum (HP:0001549)2.48979263
23Chronic hepatic failure (HP:0100626)2.48941788
24Poor coordination (HP:0002370)2.48240974
25Abnormality of the renal medulla (HP:0100957)2.42754770
26Drooling (HP:0002307)2.38976263
27Abnormality of chromosome stability (HP:0003220)2.37612892
28Colon cancer (HP:0003003)2.31359705
29Optic nerve hypoplasia (HP:0000609)2.30277871
30Hepatoblastoma (HP:0002884)2.29362448
31Postaxial hand polydactyly (HP:0001162)2.25285880
32Chromsome breakage (HP:0040012)2.19248901
33Aplasia/Hypoplasia of the sternum (HP:0006714)2.13599987
34Abnormal lung lobation (HP:0002101)2.13499225
35Sloping forehead (HP:0000340)2.12581518
36Excessive salivation (HP:0003781)2.12477823
37Decreased testicular size (HP:0008734)2.09153342
38Postaxial foot polydactyly (HP:0001830)2.09066464
39Progressive inability to walk (HP:0002505)2.08089664
40Methylmalonic acidemia (HP:0002912)2.07690572
41Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07284573
42Astigmatism (HP:0000483)2.05196063
43Small intestinal stenosis (HP:0012848)2.01669118
44Duodenal stenosis (HP:0100867)2.01669118
45Long clavicles (HP:0000890)1.99624012
46Abnormality of the metopic suture (HP:0005556)1.97758757
47Cortical dysplasia (HP:0002539)1.97131581
48Broad foot (HP:0001769)1.96855721
49Thyroid-stimulating hormone excess (HP:0002925)1.96739772
50Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96544751
51Absent speech (HP:0001344)1.95244638
52Oligodactyly (hands) (HP:0001180)1.95142014
53Abnormality of the hip-girdle musculature (HP:0001445)1.92892658
54Abnormality of the musculature of the pelvis (HP:0001469)1.92892658
55Narrow forehead (HP:0000341)1.91420703
56Gonadotropin excess (HP:0000837)1.90767182
57Hyperglycinemia (HP:0002154)1.90706106
58Abnormality of the duodenum (HP:0002246)1.89690613
59Lissencephaly (HP:0001339)1.88721274
60Retinal dysplasia (HP:0007973)1.86648715
61Preaxial hand polydactyly (HP:0001177)1.86493795
62Absent septum pellucidum (HP:0001331)1.86484601
63Aganglionic megacolon (HP:0002251)1.85641398
64Medulloblastoma (HP:0002885)1.84292821
65Abnormality of the renal cortex (HP:0011035)1.84271243
66Pelvic girdle muscle weakness (HP:0003749)1.83197125
67Ependymoma (HP:0002888)1.83113699
68Specific learning disability (HP:0001328)1.82694917
69Abnormality of the septum pellucidum (HP:0007375)1.80518392
70Aplasia/Hypoplasia of the tongue (HP:0010295)1.80391071
71Micropenis (HP:0000054)1.79676741
72Anencephaly (HP:0002323)1.78220128
73Renal cortical cysts (HP:0000803)1.77203203
74Occipital encephalocele (HP:0002085)1.76388117
75Labial hypoplasia (HP:0000066)1.74245194
76Abnormality of the preputium (HP:0100587)1.73907260
77Nephroblastoma (Wilms tumor) (HP:0002667)1.73804899
78Multicystic kidney dysplasia (HP:0000003)1.73398485
79Unilateral renal agenesis (HP:0000122)1.72347874
80Short foot (HP:0001773)1.72325957
81Gastrointestinal atresia (HP:0002589)1.70838197
82Supernumerary spleens (HP:0009799)1.70609959
83Embryonal renal neoplasm (HP:0011794)1.68948641
84Type II lissencephaly (HP:0007260)1.68173851
85Dandy-Walker malformation (HP:0001305)1.67830427
86Prominent nasal bridge (HP:0000426)1.67788874
87Bifid tongue (HP:0010297)1.67095237
88Pachygyria (HP:0001302)1.66707072
89Rimmed vacuoles (HP:0003805)1.65184018
90Median cleft lip (HP:0000161)1.64895603
91Atrophy/Degeneration involving motor neurons (HP:0007373)1.64760266
92Hypoplastic female external genitalia (HP:0012815)1.64033431
93Acute necrotizing encephalopathy (HP:0006965)1.63988490
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.63607883
95Triphalangeal thumb (HP:0001199)1.63435974
96Sclerocornea (HP:0000647)1.63159416
97Decreased lacrimation (HP:0000633)1.62543862
98Neoplasm of the oral cavity (HP:0100649)1.62446217
99Inability to walk (HP:0002540)1.62363680
100Cystic liver disease (HP:0006706)1.60881702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCR3.89692183
2TRIM283.73866290
3WNK33.31956512
4SRPK12.63326347
5EPHA42.59041981
6MAP3K42.25085444
7FRK2.24720183
8CASK2.21547826
9MAP2K72.13069723
10EIF2AK32.00789480
11PLK21.87568519
12BMPR1B1.86106082
13MAP4K21.80473076
14MARK11.78990532
15NUAK11.78180626
16PINK11.68984860
17ZAK1.67519003
18CSNK1A1L1.66287821
19BRSK21.65159635
20CSNK1G31.64887108
21PLK41.61765213
22ERBB31.60057931
23CSNK1G21.58684679
24CSNK1G11.58654198
25PLK31.57356098
26MAPK131.56836517
27BUB11.51892962
28PNCK1.49849481
29MUSK1.40295719
30DYRK31.36864189
31AKT31.36759510
32VRK11.32178100
33MKNK11.30633784
34SIK31.30348272
35MINK11.29604636
36NEK11.29195849
37WEE11.25346650
38TTK1.22236640
39MKNK21.19400598
40CDK191.19295403
41CDC71.13395021
42PLK11.10849241
43STK38L1.09085976
44DYRK21.09052614
45TNIK1.02201814
46UHMK11.01957305
47ACVR1B0.95884921
48LATS10.95614251
49ATR0.95035595
50TSSK60.94441778
51BRD40.93911136
52MAP3K50.88662334
53EPHA30.87919749
54STK160.81393526
55ATM0.78681116
56CCNB10.76555462
57PRKCE0.76056179
58ADRBK20.75431896
59INSRR0.74004702
60NTRK20.72006311
61CDK30.71457223
62TAF10.66072026
63BRSK10.65286427
64CHEK20.64914668
65BCKDK0.63875149
66DYRK1B0.62497317
67RPS6KA40.61868274
68FLT30.60021777
69FER0.59246245
70DYRK1A0.58677522
71VRK20.58338147
72STK390.58123395
73TAOK30.55946854
74PRKCG0.55696055
75CDK140.54643606
76OXSR10.54108716
77TGFBR10.53707504
78NEK20.53406795
79GRK10.53233399
80CSNK1A10.48353389
81OBSCN0.47774847
82CHEK10.47035082
83CDK90.46978222
84MAP2K40.45944019
85CAMK2A0.45603422
86PBK0.45512719
87AURKB0.44029065
88CSNK1D0.43922194
89STK30.43514914
90MAPKAPK50.43162679
91CDK180.42214530
92CAMKK20.40418676
93CSNK1E0.40354721
94PKN10.39330615
95CDK10.38653701
96YES10.37646807
97PAK30.36115027
98CDK20.33972005
99CDK60.33821184
100CSNK2A10.31629501

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034502.99041694
2Mismatch repair_Homo sapiens_hsa034302.97774627
3Basal transcription factors_Homo sapiens_hsa030222.96987658
4Fanconi anemia pathway_Homo sapiens_hsa034602.89056901
5Protein export_Homo sapiens_hsa030602.82669767
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.65945106
7Homologous recombination_Homo sapiens_hsa034402.32884263
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14235551
9RNA polymerase_Homo sapiens_hsa030202.13531747
10Steroid biosynthesis_Homo sapiens_hsa001002.13366433
11RNA degradation_Homo sapiens_hsa030182.11757702
12Propanoate metabolism_Homo sapiens_hsa006402.11661623
13Phototransduction_Homo sapiens_hsa047442.11347657
14RNA transport_Homo sapiens_hsa030132.09904588
15Nicotine addiction_Homo sapiens_hsa050332.06779934
16Cell cycle_Homo sapiens_hsa041102.02969520
17DNA replication_Homo sapiens_hsa030301.97354623
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94289961
19Spliceosome_Homo sapiens_hsa030401.93371955
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85214977
21Nucleotide excision repair_Homo sapiens_hsa034201.82998565
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.79970396
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74917487
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68530269
25mRNA surveillance pathway_Homo sapiens_hsa030151.66271773
26Oocyte meiosis_Homo sapiens_hsa041141.59544675
27Base excision repair_Homo sapiens_hsa034101.56133199
28Regulation of autophagy_Homo sapiens_hsa041401.55879794
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45198127
30Butanoate metabolism_Homo sapiens_hsa006501.41783375
31Oxidative phosphorylation_Homo sapiens_hsa001901.39124959
32Proteasome_Homo sapiens_hsa030501.36741032
33Parkinsons disease_Homo sapiens_hsa050121.34376908
34GABAergic synapse_Homo sapiens_hsa047271.27888765
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24582876
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.23137973
37Selenocompound metabolism_Homo sapiens_hsa004501.22548397
38p53 signaling pathway_Homo sapiens_hsa041151.16658643
39Huntingtons disease_Homo sapiens_hsa050161.12613285
40Circadian rhythm_Homo sapiens_hsa047101.12469368
41Fatty acid elongation_Homo sapiens_hsa000621.08274102
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07586505
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06276968
44Pyrimidine metabolism_Homo sapiens_hsa002401.05247241
45Purine metabolism_Homo sapiens_hsa002301.02771866
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02076922
47Taste transduction_Homo sapiens_hsa047420.98166949
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96145491
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93400517
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91420450
51Morphine addiction_Homo sapiens_hsa050320.88543606
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87140487
53Peroxisome_Homo sapiens_hsa041460.86729572
54Dopaminergic synapse_Homo sapiens_hsa047280.82320955
55Olfactory transduction_Homo sapiens_hsa047400.82286124
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75201235
57Hedgehog signaling pathway_Homo sapiens_hsa043400.73045160
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69871634
59Alcoholism_Homo sapiens_hsa050340.69710969
60One carbon pool by folate_Homo sapiens_hsa006700.64748142
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64613693
62Fatty acid metabolism_Homo sapiens_hsa012120.64393850
63Caffeine metabolism_Homo sapiens_hsa002320.63916044
64Circadian entrainment_Homo sapiens_hsa047130.62926395
65Pyruvate metabolism_Homo sapiens_hsa006200.60438043
66Synaptic vesicle cycle_Homo sapiens_hsa047210.59714556
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58760338
68Vitamin B6 metabolism_Homo sapiens_hsa007500.56095184
69Lysine degradation_Homo sapiens_hsa003100.55182189
70Alzheimers disease_Homo sapiens_hsa050100.54735855
71Glutamatergic synapse_Homo sapiens_hsa047240.52296495
72Hippo signaling pathway_Homo sapiens_hsa043900.52172135
73Metabolic pathways_Homo sapiens_hsa011000.51936058
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51737388
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51594941
76Serotonergic synapse_Homo sapiens_hsa047260.50572086
77Collecting duct acid secretion_Homo sapiens_hsa049660.49997104
78TGF-beta signaling pathway_Homo sapiens_hsa043500.48741628
79Long-term depression_Homo sapiens_hsa047300.46958837
80Wnt signaling pathway_Homo sapiens_hsa043100.43291990
81beta-Alanine metabolism_Homo sapiens_hsa004100.42541753
82Cardiac muscle contraction_Homo sapiens_hsa042600.42224657
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.41280754
84Folate biosynthesis_Homo sapiens_hsa007900.41062289
85Axon guidance_Homo sapiens_hsa043600.37926962
86Ether lipid metabolism_Homo sapiens_hsa005650.36796010
87Amphetamine addiction_Homo sapiens_hsa050310.36381977
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35828606
89Cocaine addiction_Homo sapiens_hsa050300.35222723
90Nitrogen metabolism_Homo sapiens_hsa009100.32839218
91Basal cell carcinoma_Homo sapiens_hsa052170.31103602
92Linoleic acid metabolism_Homo sapiens_hsa005910.29333966
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25765398
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.25754064
95Tryptophan metabolism_Homo sapiens_hsa003800.25394206
96N-Glycan biosynthesis_Homo sapiens_hsa005100.25277439
97Insulin secretion_Homo sapiens_hsa049110.24421723
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24015759
99Cholinergic synapse_Homo sapiens_hsa047250.21981147
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21709051

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