ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	lactate metabolic process (GO:0006089)	4.21899464
2	positive regulation of histone H3-K4 methylation (GO:0051571)	4.00254813
3	mitotic metaphase plate congression (GO:0007080)	3.96880467
4	synapsis (GO:0007129)	3.91680723
5	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.89934666
6	DNA replication checkpoint (GO:0000076)	3.81484479
7	regulation of mitochondrial translation (GO:0070129)	3.78910397
8	positive regulation of chromosome segregation (GO:0051984)	3.64945333
9	ribosome assembly (GO:0042255)	3.64718723
10	DNA double-strand break processing (GO:0000729)	3.55036010
11	proteasome assembly (GO:0043248)	3.49771128
12	regulation of meiosis I (GO:0060631)	3.43639221
13	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.37314961
14	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.35479501
15	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.35479501
16	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.35479501
17	cullin deneddylation (GO:0010388)	3.34793338
18	metaphase plate congression (GO:0051310)	3.34418686
19	piRNA metabolic process (GO:0034587)	3.34171355
20	regulation of cofactor metabolic process (GO:0051193)	3.25836064
21	regulation of coenzyme metabolic process (GO:0051196)	3.25836064
22	cellular ketone body metabolic process (GO:0046950)	3.24781503
23	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.24768624
24	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.17539484
25	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.17446200
26	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.17416391
27	termination of RNA polymerase III transcription (GO:0006386)	3.17416391
28	chromatin remodeling at centromere (GO:0031055)	3.15598775
29	CENP-A containing nucleosome assembly (GO:0034080)	3.15149166
30	histone exchange (GO:0043486)	3.12724696
31	nuclear pore organization (GO:0006999)	3.09881083
32	protein K6-linked ubiquitination (GO:0085020)	3.09355259
33	mitotic sister chromatid cohesion (GO:0007064)	3.09296964
34	protein deneddylation (GO:0000338)	3.07819482
35	protein localization to kinetochore (GO:0034501)	3.07653696
36	nuclear pore complex assembly (GO:0051292)	3.05811571
37	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.05098059
38	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.04715954
39	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.02955958
40	rRNA modification (GO:0000154)	3.01196386
41	binding of sperm to zona pellucida (GO:0007339)	3.01037357
42	single strand break repair (GO:0000012)	2.96439235
43	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.96230582
44	retinal cone cell development (GO:0046549)	2.95017282
45	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.93205154
46	regulation of spindle organization (GO:0090224)	2.91476333
47	spliceosomal snRNP assembly (GO:0000387)	2.90910853
48	kinetochore organization (GO:0051383)	2.90858459
49	regulation of chromosome segregation (GO:0051983)	2.88999576
50	spindle checkpoint (GO:0031577)	2.88703467
51	mitotic sister chromatid segregation (GO:0000070)	2.87600529
52	termination of RNA polymerase I transcription (GO:0006363)	2.86061582
53	positive regulation of ligase activity (GO:0051351)	2.82869215
54	ketone body metabolic process (GO:1902224)	2.81831879
55	pteridine-containing compound biosynthetic process (GO:0042559)	2.81731549
56	regulation of acrosome reaction (GO:0060046)	2.81467858
57	rRNA methylation (GO:0031167)	2.81351154
58	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.78817661
59	regulation of mitotic metaphase/anaphase transition (GO:0030071)	2.77666604
60	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	2.77666604
61	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.75539517
62	mitotic chromosome condensation (GO:0007076)	2.75076134
63	regulation of retinoic acid receptor signaling pathway (GO:0048385)	2.74617930
64	regulation of Golgi to plasma membrane protein transport (GO:0042996)	2.74412212
65	negative regulation of ligase activity (GO:0051352)	2.73397737
66	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.73397737
67	mitotic spindle checkpoint (GO:0071174)	2.70301346
68	protein localization to chromosome, centromeric region (GO:0071459)	2.69247799
69	mRNA cleavage (GO:0006379)	2.68973827
70	ribosome biogenesis (GO:0042254)	2.68888160
71	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.68868854
72	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.67182858
73	establishment of integrated proviral latency (GO:0075713)	2.65945775
74	peptidyl-histidine modification (GO:0018202)	2.65606975
75	kinetochore assembly (GO:0051382)	2.65269698
76	histone H2B ubiquitination (GO:0033523)	2.65025345
77	regulation of helicase activity (GO:0051095)	2.64728900
78	establishment of chromosome localization (GO:0051303)	2.63768281
79	male meiosis (GO:0007140)	2.63066263
80	regulation of mitotic sister chromatid separation (GO:0010965)	2.61592670
81	regulation of mitotic sister chromatid segregation (GO:0033047)	2.61592670
82	regulation of sister chromatid segregation (GO:0033045)	2.61592670
83	regulation of ligase activity (GO:0051340)	2.61215685
84	purine nucleobase biosynthetic process (GO:0009113)	2.60985348
85	male meiosis I (GO:0007141)	2.60968778
86	negative regulation of chromosome segregation (GO:0051985)	2.60596255
87	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.60475313
88	negative regulation of sister chromatid segregation (GO:0033046)	2.60475313
89	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.60475313
90	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.60475313
91	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.60475313
92	DNA catabolic process, exonucleolytic (GO:0000738)	2.60442418
93	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.60164170
94	DNA strand elongation (GO:0022616)	2.59996217
95	tRNA aminoacylation for protein translation (GO:0006418)	2.59326396
96	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.59111091
97	DNA strand elongation involved in DNA replication (GO:0006271)	2.58956873
98	tRNA aminoacylation (GO:0043039)	2.58672867
99	amino acid activation (GO:0043038)	2.58672867
100	mitochondrial RNA metabolic process (GO:0000959)	2.58320601

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.00760975
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.18937123
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.53156950
4	E2F7_22180533_ChIP-Seq_HELA_Human	4.27976089
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.76757080
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.17848843
7	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.06999269
8	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.97552300
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.70162674
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.66655097
11	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.66177489
12	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.62549781
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.59053260
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.50431212
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.49274852
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.48632540
17	AR_21909140_ChIP-Seq_LNCAP_Human	2.45498677
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.42067082
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.40379799
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.34888642
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.28093368
22	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.24225691
23	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.09502965
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.06837744
25	DCP1A_22483619_ChIP-Seq_HELA_Human	1.97493003
26	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.96615648
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.93689898
28	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.88150377
29	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.87340642
30	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.86731888
31	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.85282350
32	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.80877721
33	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.80369479
34	GABP_19822575_ChIP-Seq_HepG2_Human	1.65658344
35	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.61340262
36	TTF2_22483619_ChIP-Seq_HELA_Human	1.61243038
37	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.54071771
38	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.51526432
39	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.48359126
40	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.44422035
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.43242305
42	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.43011648
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.41989636
44	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.41749019
45	ZNF274_21170338_ChIP-Seq_K562_Hela	1.41487963
46	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.38003597
47	KDM5A_27292631_Chip-Seq_BREAST_Human	1.36750135
48	VDR_22108803_ChIP-Seq_LS180_Human	1.35864999
49	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.34675651
50	XRN2_22483619_ChIP-Seq_HELA_Human	1.33792025
51	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.33118863
52	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.31726653
53	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.31702203
54	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.31357950
55	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.27431662
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.26611885
57	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.25627345
58	TFEB_21752829_ChIP-Seq_HELA_Human	1.24916869
59	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.22859749
60	FUS_26573619_Chip-Seq_HEK293_Human	1.20409688
61	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.18507979
62	EWS_26573619_Chip-Seq_HEK293_Human	1.16950290
63	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.16075315
64	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.15500782
65	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.12770825
66	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.10300897
67	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.06430490
68	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.04498323
69	ELF5_23300383_ChIP-Seq_T47D_Human	1.04457105
70	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04325311
71	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.03968425
72	ZNF263_19887448_ChIP-Seq_K562_Human	1.03537102
73	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01830930
74	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.01363805
75	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.00417176
76	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.00083751
77	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.99610977
78	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.94775419
79	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.91777145
80	TP53_22573176_ChIP-Seq_HFKS_Human	0.89111803
81	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.85924956
82	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.85482929
83	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.83606687
84	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.81817024
85	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.81554501
86	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.81155202
87	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.79551181
88	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.79545477
89	RBPJ_21746931_ChIP-Seq_IB4_Human	0.77468821
90	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.77052636
91	PHF8_20622853_ChIP-Seq_HELA_Human	0.77002236
92	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.76926836
93	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.76844030
94	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.76795803
95	HTT_18923047_ChIP-ChIP_STHdh_Human	0.76121924
96	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.73008471
97	CIITA_25753668_ChIP-Seq_RAJI_Human	0.72892398
98	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.72280845
99	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.70591007
100	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.70305967

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	3.99212321
2	MP0010234_abnormal_vibrissa_follicle	3.86075159
3	MP0008058_abnormal_DNA_repair	3.77390135
4	MP0003718_maternal_effect	3.49690657
5	MP0005379_endocrine/exocrine_gland_phen	3.22888345
6	MP0008877_abnormal_DNA_methylation	3.14134422
7	MP0010094_abnormal_chromosome_stability	2.97251925
8	MP0008057_abnormal_DNA_replication	2.91958413
9	MP0004957_abnormal_blastocyst_morpholog	2.74585589
10	MP0003077_abnormal_cell_cycle	2.57335387
11	MP0002163_abnormal_gland_morphology	2.46196555
12	MP0003111_abnormal_nucleus_morphology	2.44087589
13	MP0003941_abnormal_skin_development	2.42530313
14	MP0003806_abnormal_nucleotide_metabolis	2.15690041
15	MP0002796_impaired_skin_barrier	2.02202325
16	MP0008789_abnormal_olfactory_epithelium	1.99533304
17	MP0003787_abnormal_imprinting	1.94427391
18	MP0005174_abnormal_tail_pigmentation	1.88702023
19	MP0008007_abnormal_cellular_replicative	1.85788868
20	MP0001929_abnormal_gametogenesis	1.78543941
21	MP0003786_premature_aging	1.72558256
22	MP0003123_paternal_imprinting	1.71673382
23	MP0003950_abnormal_plasma_membrane	1.71602853
24	MP0002938_white_spotting	1.69184240
25	MP0002210_abnormal_sex_determination	1.68627020
26	MP0001188_hyperpigmentation	1.67281373
27	MP0003121_genomic_imprinting	1.65687996
28	MP0006036_abnormal_mitochondrial_physio	1.65650249
29	MP0002160_abnormal_reproductive_system	1.64837056
30	MP0008995_early_reproductive_senescence	1.63474824
31	MP0002837_dystrophic_cardiac_calcinosis	1.61953961
32	MP0005410_abnormal_fertilization	1.55434358
33	MP0005394_taste/olfaction_phenotype	1.54522114
34	MP0005499_abnormal_olfactory_system	1.54522114
35	MP0006035_abnormal_mitochondrial_morpho	1.51026564
36	MP0009697_abnormal_copulation	1.50189372
37	MP0008932_abnormal_embryonic_tissue	1.49851017
38	MP0006072_abnormal_retinal_apoptosis	1.45499948
39	MP0003122_maternal_imprinting	1.40958470
40	MP0000372_irregular_coat_pigmentation	1.40798768
41	MP0003195_calcinosis	1.40652968
42	MP0000653_abnormal_sex_gland	1.36672617
43	MP0001145_abnormal_male_reproductive	1.35881761
44	MP0002139_abnormal_hepatobiliary_system	1.35234556
45	MP0005645_abnormal_hypothalamus_physiol	1.33413370
46	MP0004270_analgesia	1.33082685
47	MP0001764_abnormal_homeostasis	1.32223344
48	MP0010352_gastrointestinal_tract_polyps	1.30727767
49	MP0005395_other_phenotype	1.30589451
50	MP0003698_abnormal_male_reproductive	1.26807334
51	MP0003186_abnormal_redox_activity	1.22849975
52	MP0010678_abnormal_skin_adnexa	1.16083139
53	MP0000350_abnormal_cell_proliferation	1.13454224
54	MP0001730_embryonic_growth_arrest	1.12422023
55	MP0002638_abnormal_pupillary_reflex	1.11458696
56	MP0005501_abnormal_skin_physiology	1.07441714
57	MP0002161_abnormal_fertility/fecundity	1.07397364
58	MP0003699_abnormal_female_reproductive	1.05770752
59	MP0005647_abnormal_sex_gland	1.03558155
60	MP0004215_abnormal_myocardial_fiber	0.99308049
61	MP0010307_abnormal_tumor_latency	0.97409879
62	MP0005332_abnormal_amino_acid	0.96495756
63	MP0001697_abnormal_embryo_size	0.93465429
64	MP0005360_urolithiasis	0.93034698
65	MP0001984_abnormal_olfaction	0.92808250
66	MP0001529_abnormal_vocalization	0.92266730
67	MP0004019_abnormal_vitamin_homeostasis	0.91079049
68	MP0001944_abnormal_pancreas_morphology	0.90526470
69	MP0005636_abnormal_mineral_homeostasis	0.90318746
70	MP0005220_abnormal_exocrine_pancreas	0.90005063
71	MP0000358_abnormal_cell_content/	0.88710081
72	MP0001672_abnormal_embryogenesis/_devel	0.87488444
73	MP0005380_embryogenesis_phenotype	0.87488444
74	MP0005389_reproductive_system_phenotype	0.87386955
75	MP0006292_abnormal_olfactory_placode	0.83126002
76	MP0003890_abnormal_embryonic-extraembry	0.82590372
77	MP0002080_prenatal_lethality	0.81349048
78	MP0001756_abnormal_urination	0.80839650
79	MP0002138_abnormal_hepatobiliary_system	0.79240321
80	MP0002084_abnormal_developmental_patter	0.78087444
81	MP0001986_abnormal_taste_sensitivity	0.77813540
82	MP0002909_abnormal_adrenal_gland	0.77446221
83	MP0009672_abnormal_birth_weight	0.75696865
84	MP0000313_abnormal_cell_death	0.73528531
85	MP0005253_abnormal_eye_physiology	0.72057932
86	MP0009379_abnormal_foot_pigmentation	0.71249250
87	MP0005365_abnormal_bile_salt	0.71141489
88	MP0000013_abnormal_adipose_tissue	0.69417866
89	MP0001119_abnormal_female_reproductive	0.68977107
90	MP0001216_abnormal_epidermal_layer	0.67416374
91	MP0000516_abnormal_urinary_system	0.67049261
92	MP0005367_renal/urinary_system_phenotyp	0.67049261
93	MP0003984_embryonic_growth_retardation	0.66474022
94	MP0002090_abnormal_vision	0.66019082
95	MP0002085_abnormal_embryonic_tissue	0.65590347
96	MP0004782_abnormal_surfactant_physiolog	0.65428937
97	MP0004197_abnormal_fetal_growth/weight/	0.65309256
98	MP0002233_abnormal_nose_morphology	0.65305744
99	MP0001666_abnormal_nutrient_absorption	0.64671147
100	MP0002088_abnormal_embryonic_growth/wei	0.63692114

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of methionine metabolism (HP:0010901)	3.61932368
2	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.97037309
3	Abnormality of the labia minora (HP:0012880)	2.90599658
4	Sensory axonal neuropathy (HP:0003390)	2.80077992
5	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.69616395
6	3-Methylglutaconic aciduria (HP:0003535)	2.67165877
7	Chromsome breakage (HP:0040012)	2.58659132
8	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.57344655
9	Progressive macrocephaly (HP:0004481)	2.46330392
10	Microvesicular hepatic steatosis (HP:0001414)	2.45462559
11	Hypoglycemic coma (HP:0001325)	2.43127008
12	Lipid accumulation in hepatocytes (HP:0006561)	2.41888567
13	Increased hepatocellular lipid droplets (HP:0006565)	2.40796499
14	Methylmalonic acidemia (HP:0002912)	2.40774076
15	Megaloblastic anemia (HP:0001889)	2.40370438
16	Acute necrotizing encephalopathy (HP:0006965)	2.40305455
17	Abnormality of vitamin B metabolism (HP:0004340)	2.40300967
18	Adrenal hypoplasia (HP:0000835)	2.33710310
19	Acute encephalopathy (HP:0006846)	2.29942367
20	Intrahepatic cholestasis (HP:0001406)	2.28444677
21	Median cleft lip (HP:0000161)	2.27869359
22	Hypoglycemic seizures (HP:0002173)	2.26836366
23	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.26721735
24	Hyperinsulinemic hypoglycemia (HP:0000825)	2.25403577
25	Abnormality of the preputium (HP:0100587)	2.23719719
26	Homocystinuria (HP:0002156)	2.22715486
27	Abnormality of homocysteine metabolism (HP:0010919)	2.22715486
28	Volvulus (HP:0002580)	2.21623139
29	Increased CSF lactate (HP:0002490)	2.20709874
30	Symptomatic seizures (HP:0011145)	2.20177233
31	Birth length less than 3rd percentile (HP:0003561)	2.18738746
32	Congenital ichthyosiform erythroderma (HP:0007431)	2.15585688
33	Abnormal sex determination (HP:0012244)	2.14413690
34	Sex reversal (HP:0012245)	2.14413690
35	Papillary thyroid carcinoma (HP:0002895)	2.10459086
36	Premature ovarian failure (HP:0008209)	2.08750783
37	Abnormal mitochondria in muscle tissue (HP:0008316)	2.07997673
38	Absent thumb (HP:0009777)	2.07172761
39	Reduced antithrombin III activity (HP:0001976)	2.06953107
40	Azoospermia (HP:0000027)	2.06246222
41	Meckel diverticulum (HP:0002245)	2.05961426
42	Methylmalonic aciduria (HP:0012120)	2.00828343
43	Nephroblastoma (Wilms tumor) (HP:0002667)	1.99898206
44	Hypobetalipoproteinemia (HP:0003563)	1.99837578
45	Thyroid carcinoma (HP:0002890)	1.99758476
46	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.99504343
47	Limb hypertonia (HP:0002509)	1.99104448
48	Neoplasm of the adrenal gland (HP:0100631)	1.98797700
49	Abnormal hair whorl (HP:0010721)	1.98525377
50	Aplasia/hypoplasia of the uterus (HP:0008684)	1.98043988
51	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.97257050
52	Increased serum lactate (HP:0002151)	1.97165822
53	Abnormality of the ileum (HP:0001549)	1.96973342
54	Renal Fanconi syndrome (HP:0001994)	1.96072640
55	Gonadal dysgenesis (HP:0000133)	1.95733125
56	Supernumerary spleens (HP:0009799)	1.95384963
57	Abnormality of chromosome stability (HP:0003220)	1.95189039
58	Abnormal lung lobation (HP:0002101)	1.94105338
59	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.93565162
60	Cerebellar dysplasia (HP:0007033)	1.91546749
61	Increased serum pyruvate (HP:0003542)	1.91463933
62	Pancreatic cysts (HP:0001737)	1.91380126
63	Pancreatic fibrosis (HP:0100732)	1.90630214
64	Abnormal spermatogenesis (HP:0008669)	1.90203296
65	Abnormality of vitamin metabolism (HP:0100508)	1.88158648
66	Hypoplasia of the uterus (HP:0000013)	1.86807687
67	Horseshoe kidney (HP:0000085)	1.86804435
68	Cerebral edema (HP:0002181)	1.84949996
69	Abnormal pancreas size (HP:0012094)	1.84466684
70	Mitochondrial inheritance (HP:0001427)	1.84286778
71	Breast carcinoma (HP:0003002)	1.83926700
72	Abnormality of the anterior horn cell (HP:0006802)	1.82994530
73	Degeneration of anterior horn cells (HP:0002398)	1.82994530
74	CNS hypomyelination (HP:0003429)	1.82622738
75	Neoplasm of the adrenal cortex (HP:0100641)	1.82493594
76	Prominent metopic ridge (HP:0005487)	1.81622758
77	Embryonal renal neoplasm (HP:0011794)	1.81335919
78	Lip pit (HP:0100267)	1.81064786
79	Abnormality of placental membranes (HP:0011409)	1.80242138
80	Amniotic constriction ring (HP:0009775)	1.80242138
81	Hypokinesia (HP:0002375)	1.79701755
82	Abnormal biliary tract physiology (HP:0012439)	1.79437697
83	Bile duct proliferation (HP:0001408)	1.79437697
84	Intestinal atresia (HP:0011100)	1.78732784
85	Squamous cell carcinoma (HP:0002860)	1.77700785
86	Hepatic necrosis (HP:0002605)	1.77403769
87	Congenital malformation of the right heart (HP:0011723)	1.76783688
88	Double outlet right ventricle (HP:0001719)	1.76783688
89	Hypergonadotropic hypogonadism (HP:0000815)	1.76177366
90	Type I transferrin isoform profile (HP:0003642)	1.75166441
91	Multiple enchondromatosis (HP:0005701)	1.72823918
92	Male pseudohermaphroditism (HP:0000037)	1.72704432
93	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.71811610
94	Progressive muscle weakness (HP:0003323)	1.71380656
95	Absent radius (HP:0003974)	1.71306802
96	Abnormality of urine glucose concentration (HP:0011016)	1.70933481
97	Glycosuria (HP:0003076)	1.70933481
98	Pancreatic islet-cell hyperplasia (HP:0004510)	1.70533854
99	Ketoacidosis (HP:0001993)	1.70293208
100	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.69501347

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	3.98668535
2	MST4	3.90781228
3	PBK	3.67689385
4	SRPK1	3.54146014
5	BUB1	3.34455700
6	FRK	2.94871960
7	STK16	2.89942008
8	BRSK2	2.89795219
9	NEK1	2.67469474
10	TTK	2.47958532
11	EIF2AK3	2.38989920
12	TSSK6	2.37042395
13	ZAK	2.27056290
14	PINK1	2.14969213
15	PLK3	2.02986938
16	TRIM28	1.93327905
17	CDC7	1.89072091
18	CASK	1.85610537
19	BRSK1	1.73282559
20	STK38L	1.66816471
21	PLK1	1.60252447
22	EPHA2	1.57881875
23	WEE1	1.54401387
24	MAP4K2	1.52447624
25	MKNK2	1.50019964
26	NUAK1	1.45435799
27	PLK4	1.27699434
28	EIF2AK1	1.24887034
29	VRK1	1.24820543
30	MARK3	1.22942320
31	BMPR1B	1.17617354
32	FGFR2	1.14994718
33	RPS6KA4	1.14883682
34	MUSK	1.14752263
35	MAP3K12	1.08396334
36	MAP2K7	1.04508808
37	ACVR1B	1.04256131
38	CSNK1G1	1.04222908
39	CSNK1G3	1.03125395
40	BRD4	1.00180978
41	STK3	0.99351025
42	AURKB	0.96047976
43	NME2	0.95125461
44	STK24	0.92825407
45	WNK3	0.91786600
46	CHEK2	0.90630166
47	NME1	0.90321115
48	MKNK1	0.88306233
49	STK39	0.86641331
50	SCYL2	0.86569077
51	ATM	0.85087792
52	BRAF	0.84961248
53	GRK1	0.83887307
54	PDK2	0.83279821
55	CCNB1	0.82250408
56	AURKA	0.80173353
57	DYRK3	0.77601884
58	CHEK1	0.76307414
59	NEK2	0.72480992
60	ARAF	0.68391734
61	BCR	0.66820126
62	NEK6	0.65906602
63	PNCK	0.65707626
64	CSNK1G2	0.63613011
65	PRKCI	0.61678304
66	MST1R	0.58462006
67	RPS6KA5	0.57928604
68	VRK2	0.57646296
69	CSNK2A2	0.56767595
70	PASK	0.56745085
71	STK4	0.55449695
72	TAF1	0.53746861
73	WNK4	0.53639283
74	CDK3	0.53242591
75	ATR	0.53049387
76	CDK7	0.52562227
77	TNIK	0.52528919
78	CSNK2A1	0.51112368
79	MAP3K8	0.50151856
80	OXSR1	0.47587165
81	PAK1	0.43940656
82	AKT3	0.43419434
83	STK10	0.42950749
84	EIF2AK2	0.42318510
85	LATS1	0.38985940
86	CDK1	0.38666482
87	CSNK1A1L	0.38182801
88	CSNK1E	0.36065927
89	MET	0.35964264
90	TLK1	0.34822337
91	MAP3K4	0.34452520
92	YES1	0.31686315
93	PRKAA1	0.31676507
94	RAF1	0.31451844
95	ERBB3	0.31167229
96	CDK2	0.29852034
97	CDK8	0.24721939
98	CSNK1A1	0.24688520
99	LMTK2	0.22600618
100	RPS6KB1	0.20644459

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.32568969
2	Proteasome_Homo sapiens_hsa03050	3.06740152
3	Basal transcription factors_Homo sapiens_hsa03022	3.04184389
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.86155353
5	Mismatch repair_Homo sapiens_hsa03430	2.73582599
6	RNA polymerase_Homo sapiens_hsa03020	2.63001242
7	DNA replication_Homo sapiens_hsa03030	2.32702095
8	Protein export_Homo sapiens_hsa03060	2.30423419
9	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.30255823
10	RNA transport_Homo sapiens_hsa03013	2.24477739
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.11305394
12	Folate biosynthesis_Homo sapiens_hsa00790	2.09660627
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.07557290
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.95765733
15	Propanoate metabolism_Homo sapiens_hsa00640	1.93545737
16	Homologous recombination_Homo sapiens_hsa03440	1.88861352
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.81211886
18	Pyruvate metabolism_Homo sapiens_hsa00620	1.80274271
19	Cell cycle_Homo sapiens_hsa04110	1.80113786
20	RNA degradation_Homo sapiens_hsa03018	1.79681892
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.76069733
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.70983132
23	Non-homologous end-joining_Homo sapiens_hsa03450	1.69878371
24	One carbon pool by folate_Homo sapiens_hsa00670	1.67536645
25	Parkinsons disease_Homo sapiens_hsa05012	1.66412896
26	Spliceosome_Homo sapiens_hsa03040	1.63812417
27	Butanoate metabolism_Homo sapiens_hsa00650	1.60688449
28	Pyrimidine metabolism_Homo sapiens_hsa00240	1.60024568
29	Fatty acid elongation_Homo sapiens_hsa00062	1.59221779
30	Ribosome_Homo sapiens_hsa03010	1.56054030
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.47471699
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.44949006
33	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.42820514
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.41003744
35	Steroid biosynthesis_Homo sapiens_hsa00100	1.38324005
36	Oocyte meiosis_Homo sapiens_hsa04114	1.36587383
37	Huntingtons disease_Homo sapiens_hsa05016	1.34187213
38	Base excision repair_Homo sapiens_hsa03410	1.28851659
39	Purine metabolism_Homo sapiens_hsa00230	1.27946252
40	Sulfur metabolism_Homo sapiens_hsa00920	1.19052834
41	Collecting duct acid secretion_Homo sapiens_hsa04966	1.18628875
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.11952691
43	Fatty acid metabolism_Homo sapiens_hsa01212	1.04955070
44	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.02090922
45	p53 signaling pathway_Homo sapiens_hsa04115	1.01695220
46	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.00233272
47	mRNA surveillance pathway_Homo sapiens_hsa03015	0.98250340
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.93241868
49	Peroxisome_Homo sapiens_hsa04146	0.92300756
50	Sulfur relay system_Homo sapiens_hsa04122	0.86540436
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.85111756
52	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.84040410
53	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.83716552
54	Glutathione metabolism_Homo sapiens_hsa00480	0.83440428
55	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.82890057
56	Sphingolipid metabolism_Homo sapiens_hsa00600	0.82634495
57	Carbon metabolism_Homo sapiens_hsa01200	0.82621650
58	Fatty acid degradation_Homo sapiens_hsa00071	0.80209326
59	Alzheimers disease_Homo sapiens_hsa05010	0.77217589
60	Metabolic pathways_Homo sapiens_hsa01100	0.76165040
61	Arginine biosynthesis_Homo sapiens_hsa00220	0.75399467
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.75240294
63	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.74629383
64	Regulation of autophagy_Homo sapiens_hsa04140	0.74214898
65	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.72736275
66	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.71903581
67	Vibrio cholerae infection_Homo sapiens_hsa05110	0.69626915
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68036762
69	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.67977843
70	Tryptophan metabolism_Homo sapiens_hsa00380	0.67484312
71	Circadian rhythm_Homo sapiens_hsa04710	0.65573103
72	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.60448773
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.60282329
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.59853160
75	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.52559251
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50845477
77	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.50687159
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49422760
79	Retinol metabolism_Homo sapiens_hsa00830	0.48255333
80	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.46340922
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45486680
82	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.42612510
83	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.39111081
84	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.38981671
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37665497
86	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.35925780
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34485879
88	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.33591088
89	Caffeine metabolism_Homo sapiens_hsa00232	0.32788000
90	Phototransduction_Homo sapiens_hsa04744	0.30085369
91	Alcoholism_Homo sapiens_hsa05034	0.29985896
92	Olfactory transduction_Homo sapiens_hsa04740	0.29966691
93	Cardiac muscle contraction_Homo sapiens_hsa04260	0.29385177
94	Chemical carcinogenesis_Homo sapiens_hsa05204	0.29332715
95	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.29324962
96	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.29195470
97	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.29126111
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.28846333
99	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.27875144
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.27626222

ZNF57

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »