ZNF572

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.44984063
2mitotic sister chromatid cohesion (GO:0007064)5.63493275
3positive regulation of male gonad development (GO:2000020)5.51549970
4nuclear pore organization (GO:0006999)5.31960456
5nuclear pore complex assembly (GO:0051292)5.31562722
6regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.24725565
7branching involved in prostate gland morphogenesis (GO:0060442)5.19371456
8negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)5.01797532
9regulation of centriole replication (GO:0046599)4.97199361
10regulation of histone H3-K27 methylation (GO:0061085)4.61411886
11regulation of male gonad development (GO:2000018)4.47318256
12regulation of mesenchymal cell apoptotic process (GO:2001053)4.17606152
13regulation of RNA export from nucleus (GO:0046831)4.08478217
14histone-serine phosphorylation (GO:0035404)4.03807884
15mitotic chromosome condensation (GO:0007076)4.03354454
16negative regulation of DNA repair (GO:0045738)3.78028344
17prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.74157228
18regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.72581079
19mRNA modification (GO:0016556)3.68360901
20negative regulation of fibroblast apoptotic process (GO:2000270)3.66057423
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.61971681
22regulation of mitotic spindle organization (GO:0060236)3.61905982
23mitotic nuclear envelope disassembly (GO:0007077)3.60567285
24positive regulation of mitotic sister chromatid separation (GO:1901970)3.59256709
25positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.59256709
26positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.59256709
27regulation of DNA endoreduplication (GO:0032875)3.54262394
28pore complex assembly (GO:0046931)3.48925408
29DNA topological change (GO:0006265)3.48186452
30positive regulation of megakaryocyte differentiation (GO:0045654)3.46809849
31definitive hemopoiesis (GO:0060216)3.45597224
32axon extension involved in axon guidance (GO:0048846)3.43477512
33neuron projection extension involved in neuron projection guidance (GO:1902284)3.43477512
34regulation of translational termination (GO:0006449)3.42717811
35folic acid-containing compound biosynthetic process (GO:0009396)3.36740286
36DNA unwinding involved in DNA replication (GO:0006268)3.36449864
37chromosome condensation (GO:0030261)3.33643592
38regulation of centrosome duplication (GO:0010824)3.32300390
39membrane disassembly (GO:0030397)3.31733138
40nuclear envelope disassembly (GO:0051081)3.31733138
41peptidyl-histidine modification (GO:0018202)3.28357996
42regulation of stem cell maintenance (GO:2000036)3.27974262
43regulation of sister chromatid cohesion (GO:0007063)3.26283710
44regulation of centrosome cycle (GO:0046605)3.21722690
45regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.21416914
46regulation of mitotic sister chromatid separation (GO:0010965)3.20696418
47regulation of mitotic sister chromatid segregation (GO:0033047)3.20696418
48regulation of sister chromatid segregation (GO:0033045)3.20696418
49prostate gland growth (GO:0060736)3.19180065
50regulation of mRNA 3-end processing (GO:0031440)3.16838715
51negative regulation of chromosome segregation (GO:0051985)3.16729485
52regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14193964
53regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14193964
54regulation of nucleobase-containing compound transport (GO:0032239)3.13215645
55substrate-dependent cell migration (GO:0006929)3.11836925
56positive regulation of chromosome segregation (GO:0051984)3.10570316
57positive regulation of mRNA 3-end processing (GO:0031442)3.10268867
58regulation of chromosome segregation (GO:0051983)3.09330347
59negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.08650946
60negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.08650946
61negative regulation of mitotic sister chromatid segregation (GO:0033048)3.08650946
62negative regulation of mitotic sister chromatid separation (GO:2000816)3.08650946
63negative regulation of sister chromatid segregation (GO:0033046)3.08650946
64mRNA cleavage (GO:0006379)3.06688850
65positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.05049884
66regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.05049884
67negative regulation of mRNA metabolic process (GO:1903312)3.04955764
68sister chromatid segregation (GO:0000819)3.04942676
69regulation of cell proliferation involved in kidney development (GO:1901722)3.04484768
70histone H2B ubiquitination (GO:0033523)3.04128471
71embryonic camera-type eye morphogenesis (GO:0048596)3.03202162
72embryonic process involved in female pregnancy (GO:0060136)3.01870657
73RNA localization (GO:0006403)3.01865220
74anterior/posterior axis specification, embryo (GO:0008595)2.97572886
75mitotic recombination (GO:0006312)2.97196988
76positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.96770434
77regulation of DNA damage checkpoint (GO:2000001)2.96476112
78telomere maintenance via recombination (GO:0000722)2.92295994
79negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90496267
80DNA replication initiation (GO:0006270)2.90249993
81negative regulation of mitosis (GO:0045839)2.88097961
82mitotic spindle checkpoint (GO:0071174)2.87997856
83DNA strand elongation involved in DNA replication (GO:0006271)2.86999992
84mitotic spindle assembly checkpoint (GO:0007094)2.85432588
85mitotic sister chromatid segregation (GO:0000070)2.84541566
86replication fork processing (GO:0031297)2.84479804
87histone mRNA catabolic process (GO:0071044)2.83268971
88telomere maintenance (GO:0000723)2.83205097
89regulation of spindle organization (GO:0090224)2.82436151
90DNA packaging (GO:0006323)2.81269057
91telomere organization (GO:0032200)2.79886340
92mitotic metaphase plate congression (GO:0007080)2.79603259
93telomere maintenance via telomerase (GO:0007004)2.77646854
94spindle assembly checkpoint (GO:0071173)2.77214364
95DNA strand elongation (GO:0022616)2.76114083
96negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.75236431
97telomere maintenance via semi-conservative replication (GO:0032201)2.75229236
98pre-miRNA processing (GO:0031054)2.73709797
99spindle checkpoint (GO:0031577)2.72528698
100regulation of histone H3-K9 methylation (GO:0051570)2.72428699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.89869395
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.89276366
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.12243660
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.53631100
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.03955590
6PADI4_21655091_ChIP-ChIP_MCF-7_Human2.97061413
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66088813
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.61089674
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.48260620
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.34054468
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30468207
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.19539163
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18644045
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17743332
15FUS_26573619_Chip-Seq_HEK293_Human2.15437651
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12863187
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.12330427
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05359795
19ELK1_19687146_ChIP-ChIP_HELA_Human2.02281043
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01408640
21AR_21909140_ChIP-Seq_LNCAP_Human1.99692177
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.92409145
23IRF1_19129219_ChIP-ChIP_H3396_Human1.79338533
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.76864742
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76325702
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72325642
27PKCTHETA_26484144_Chip-Seq_BREAST_Human1.58525099
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.57006197
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.56923193
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56323763
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54156153
32EWS_26573619_Chip-Seq_HEK293_Human1.52268438
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51608656
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50533576
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49944816
36DCP1A_22483619_ChIP-Seq_HELA_Human1.48340727
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.47499385
38VDR_23849224_ChIP-Seq_CD4+_Human1.47450425
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.44604350
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39507099
41FOXP3_21729870_ChIP-Seq_TREG_Human1.38539342
42SOX2_16153702_ChIP-ChIP_HESCs_Human1.38169313
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37636874
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36888833
45FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36134709
46FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.35986083
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34062141
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32706261
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32349515
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.31025240
51FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.30945121
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.28304036
53KDM5A_27292631_Chip-Seq_BREAST_Human1.25808334
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.25489478
55AHR_22903824_ChIP-Seq_MCF-7_Human1.24940505
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22400908
57CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20325757
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19408456
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18405348
60TTF2_22483619_ChIP-Seq_HELA_Human1.17429222
61ZNF274_21170338_ChIP-Seq_K562_Hela1.16958911
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16784887
63NANOG_21062744_ChIP-ChIP_HESCs_Human1.12922502
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11312695
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09136572
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07920082
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05449679
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05144980
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04086777
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03122271
71SALL4_22934838_ChIP-ChIP_CD34+_Human1.02010464
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01669250
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01217106
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01217106
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01217106
76* ER_23166858_ChIP-Seq_MCF-7_Human0.99902149
77* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99237339
78SOX17_20123909_ChIP-Seq_XEN_Mouse0.98631053
79HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98422523
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98408686
81NANOG_16153702_ChIP-ChIP_HESCs_Human0.97736846
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96676560
83TFEB_21752829_ChIP-Seq_HELA_Human0.95967370
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95223771
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92917236
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92653590
87NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92477055
88SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91048211
89MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90533212
90FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88579009
91ETS1_20019798_ChIP-Seq_JURKAT_Human0.88352853
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88017325
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86985599
94CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86700778
95GATA4_21415370_ChIP-Seq_HL-1_Mouse0.86057328
96FOXA2_19822575_ChIP-Seq_HepG2_Human0.85430380
97CHD1_26751641_Chip-Seq_LNCaP_Human0.84481133
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84039971
99ELF5_23300383_ChIP-Seq_T47D_Human0.83862205
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83751200

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.77856941
2MP0010094_abnormal_chromosome_stability3.37429315
3MP0002396_abnormal_hematopoietic_system3.23981995
4MP0000537_abnormal_urethra_morphology3.18803153
5MP0008057_abnormal_DNA_replication3.15775315
6MP0000516_abnormal_urinary_system3.15698334
7MP0005367_renal/urinary_system_phenotyp3.15698334
8MP0003111_abnormal_nucleus_morphology2.84767007
9MP0002822_catalepsy2.70113598
10MP0005409_darkened_coat_color2.54490453
11MP0010030_abnormal_orbit_morphology2.45928612
12MP0004957_abnormal_blastocyst_morpholog2.38965337
13MP0003315_abnormal_perineum_morphology2.36268346
14MP0008058_abnormal_DNA_repair2.35314649
15MP0000383_abnormal_hair_follicle2.35132604
16MP0003077_abnormal_cell_cycle2.34665214
17MP0001727_abnormal_embryo_implantation2.30679773
18MP0002751_abnormal_autonomic_nervous2.29331526
19MP0009697_abnormal_copulation2.16401342
20MP0010678_abnormal_skin_adnexa2.00175608
21MP0010307_abnormal_tumor_latency1.90325872
22MP0005076_abnormal_cell_differentiation1.90017522
23MP0003943_abnormal_hepatobiliary_system1.87328016
24MP0008007_abnormal_cellular_replicative1.85986104
25MP0003942_abnormal_urinary_system1.85820082
26MP0003890_abnormal_embryonic-extraembry1.74224944
27MP0000462_abnormal_digestive_system1.71810149
28MP0001346_abnormal_lacrimal_gland1.64677683
29MP0008932_abnormal_embryonic_tissue1.62368698
30MP0001697_abnormal_embryo_size1.58904109
31MP0009780_abnormal_chondrocyte_physiolo1.54525605
32MP0005248_abnormal_Harderian_gland1.45241533
33MP0003937_abnormal_limbs/digits/tail_de1.44658057
34MP0005187_abnormal_penis_morphology1.43836442
35MP0003123_paternal_imprinting1.42528192
36MP0003718_maternal_effect1.42307153
37MP0005075_abnormal_melanosome_morpholog1.39930607
38MP0004264_abnormal_extraembryonic_tissu1.37375038
39MP0002938_white_spotting1.35784724
40MP0008995_early_reproductive_senescence1.32834280
41MP0002086_abnormal_extraembryonic_tissu1.24947864
42MP0000566_synostosis1.24405346
43MP0000350_abnormal_cell_proliferation1.24372120
44MP0000627_abnormal_mammary_gland1.22360212
45MP0001929_abnormal_gametogenesis1.21444118
46MP0005380_embryogenesis_phenotype1.20060284
47MP0001672_abnormal_embryogenesis/_devel1.20060284
48MP0003786_premature_aging1.19275097
49MP0004808_abnormal_hematopoietic_stem1.17406110
50MP0001145_abnormal_male_reproductive1.12921856
51MP0001730_embryonic_growth_arrest1.12853850
52MP0002210_abnormal_sex_determination1.10288036
53MP0000427_abnormal_hair_cycle1.09640033
54MP0002009_preneoplasia1.09542150
55MP0004197_abnormal_fetal_growth/weight/1.08867071
56MP0009703_decreased_birth_body1.08786659
57MP0002088_abnormal_embryonic_growth/wei1.08400317
58MP0003252_abnormal_bile_duct1.08231044
59MP0002084_abnormal_developmental_patter1.05660583
60MP0002080_prenatal_lethality1.04348955
61MP0000538_abnormal_urinary_bladder1.04274571
62MP0003936_abnormal_reproductive_system1.03936189
63MP0003984_embryonic_growth_retardation1.03894245
64MP0002085_abnormal_embryonic_tissue1.03845302
65MP0010234_abnormal_vibrissa_follicle1.02717567
66MP0003121_genomic_imprinting1.02114165
67MP0000428_abnormal_craniofacial_morphol1.01521765
68MP0000371_diluted_coat_color1.00114700
69MP0000358_abnormal_cell_content/0.98294258
70MP0010352_gastrointestinal_tract_polyps0.97595659
71MP0000653_abnormal_sex_gland0.96711502
72MP0005645_abnormal_hypothalamus_physiol0.96084532
73MP0002132_abnormal_respiratory_system0.94975909
74MP0001666_abnormal_nutrient_absorption0.94807653
75MP0000313_abnormal_cell_death0.94570103
76MP0002095_abnormal_skin_pigmentation0.92851932
77MP0004381_abnormal_hair_follicle0.92432351
78MP0003136_yellow_coat_color0.91778250
79MP0003868_abnormal_feces_composition0.90890876
80MP0003935_abnormal_craniofacial_develop0.90423072
81MP0000613_abnormal_salivary_gland0.89294306
82MP0000015_abnormal_ear_pigmentation0.88697660
83MP0003385_abnormal_body_wall0.88392396
84MP0002160_abnormal_reproductive_system0.88032617
85MP0004185_abnormal_adipocyte_glucose0.85272382
86MP0003698_abnormal_male_reproductive0.84572169
87MP0003705_abnormal_hypodermis_morpholog0.81273920
88MP0005379_endocrine/exocrine_gland_phen0.80031371
89MP0002254_reproductive_system_inflammat0.77705701
90MP0002233_abnormal_nose_morphology0.76404302
91MP0003656_abnormal_erythrocyte_physiolo0.75614383
92MP0002928_abnormal_bile_duct0.73478765
93MP0000377_abnormal_hair_follicle0.73045962
94MP0002139_abnormal_hepatobiliary_system0.72097671
95MP0001286_abnormal_eye_development0.72043850
96MP0002019_abnormal_tumor_incidence0.71408763
97MP0005410_abnormal_fertilization0.71161723
98MP0001661_extended_life_span0.70985917
99MP0004134_abnormal_chest_morphology0.70542374
100MP0009672_abnormal_birth_weight0.67656438

Predicted human phenotypes

RankGene SetZ-score
1Septate vagina (HP:0001153)4.74427180
2Spontaneous abortion (HP:0005268)4.72476449
3Abnormal tarsal ossification (HP:0008369)3.87812023
4Overriding aorta (HP:0002623)3.77007250
5Abnormal foot bone ossification (HP:0010675)3.63989203
6Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.59033267
7Short 1st metacarpal (HP:0010034)3.59033267
8Increased nuchal translucency (HP:0010880)3.56480342
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47320743
10Chromsome breakage (HP:0040012)3.30385749
11Abnormality of the preputium (HP:0100587)3.17095605
12Abnormality of the 1st metacarpal (HP:0010009)3.07932213
13Flat occiput (HP:0005469)3.03703451
14Abnormality of chromosome stability (HP:0003220)3.02438421
15Turricephaly (HP:0000262)3.00203935
16Meckel diverticulum (HP:0002245)2.96516027
17Microglossia (HP:0000171)2.93653625
18Septo-optic dysplasia (HP:0100842)2.92453222
19Abnormality of the carotid arteries (HP:0005344)2.90708983
20Unilateral renal agenesis (HP:0000122)2.80044933
21Abnormality of the 2nd finger (HP:0004100)2.75590551
22Abnormality of the ileum (HP:0001549)2.75113376
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.66830293
24Nephroblastoma (Wilms tumor) (HP:0002667)2.57134592
25Widely patent fontanelles and sutures (HP:0004492)2.54993742
26Short middle phalanx of finger (HP:0005819)2.53878174
27Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.51685852
28Renovascular hypertension (HP:0100817)2.48615219
29Ectopic kidney (HP:0000086)2.47215803
30Obsessive-compulsive behavior (HP:0000722)2.46550179
31Short hallux (HP:0010109)2.45059589
32Asymmetry of the thorax (HP:0001555)2.42654393
33Papillary thyroid carcinoma (HP:0002895)2.39036348
34Short phalanx of the thumb (HP:0009660)2.38885685
35Anteriorly placed anus (HP:0001545)2.36997220
36Aplasia/Hypoplasia of the hallux (HP:0008362)2.35278361
37Embryonal renal neoplasm (HP:0011794)2.31263172
38Elfin facies (HP:0004428)2.31011349
39Myelodysplasia (HP:0002863)2.29881293
40Bifid scrotum (HP:0000048)2.29388873
41Urethral obstruction (HP:0000796)2.26654336
42Renal cortical cysts (HP:0000803)2.22950653
43Bell-shaped thorax (HP:0001591)2.19647272
44Thyroid carcinoma (HP:0002890)2.12720522
45Squamous cell carcinoma (HP:0002860)2.12304617
46True hermaphroditism (HP:0010459)2.12147349
47Prolonged partial thromboplastin time (HP:0003645)2.11569663
48Severe visual impairment (HP:0001141)2.11002954
49Proximal placement of thumb (HP:0009623)2.08989662
50Renal duplication (HP:0000075)2.08598106
51Volvulus (HP:0002580)2.08477079
52Absent septum pellucidum (HP:0001331)2.07627420
53Hyperacusis (HP:0010780)2.06049752
54Short 5th finger (HP:0009237)1.99919276
55Blepharitis (HP:0000498)1.99492862
56Abnormal delivery (HP:0001787)1.99293903
57Cutaneous melanoma (HP:0012056)1.98502217
58Thin bony cortex (HP:0002753)1.98397683
59Abnormality of the septum pellucidum (HP:0007375)1.98175545
60Abnormal hand bone ossification (HP:0010660)1.94040765
61Transitional cell carcinoma of the bladder (HP:0006740)1.93240897
62Flat cornea (HP:0007720)1.92859257
63Deviation of the thumb (HP:0009603)1.92598539
64Chronic hepatic failure (HP:0100626)1.92389145
65Small intestinal stenosis (HP:0012848)1.89446608
66Duodenal stenosis (HP:0100867)1.89446608
67Popliteal pterygium (HP:0009756)1.87781403
68Wide cranial sutures (HP:0010537)1.87196033
69Choanal atresia (HP:0000453)1.85050932
70Abnormality of carpal bone ossification (HP:0006257)1.83657345
71Insidious onset (HP:0003587)1.83436965
72Termporal pattern (HP:0011008)1.83436965
73Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83128076
74Stenosis of the external auditory canal (HP:0000402)1.81386209
75Horseshoe kidney (HP:0000085)1.81219117
76Leiomyosarcoma (HP:0100243)1.81081984
77Uterine leiomyosarcoma (HP:0002891)1.81081984
78Deep philtrum (HP:0002002)1.77993284
79Thyroid-stimulating hormone excess (HP:0002925)1.76828513
80Midline defect of the nose (HP:0004122)1.76628414
81Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.73082560
82Limited elbow extension (HP:0001377)1.73001893
83Stomach cancer (HP:0012126)1.72816850
84Delayed epiphyseal ossification (HP:0002663)1.71467163
85Abnormality of the renal cortex (HP:0011035)1.71371229
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.71327588
87Esophageal atresia (HP:0002032)1.70484997
88Bladder neoplasm (HP:0009725)1.69904296
89Bladder carcinoma (HP:0002862)1.69904296
90Abnormality of DNA repair (HP:0003254)1.67320348
91Anal stenosis (HP:0002025)1.67126232
92Medulloblastoma (HP:0002885)1.66372899
93Deviation of the hallux (HP:0010051)1.66284247
94Breast carcinoma (HP:0003002)1.65442559
95Abnormality of the duodenum (HP:0002246)1.65311203
96Decreased lacrimation (HP:0000633)1.65183454
97Insomnia (HP:0100785)1.64326448
98Sloping forehead (HP:0000340)1.63420349
99Neoplasm of the thyroid gland (HP:0100031)1.62911187
100Acute myeloid leukemia (HP:0004808)1.62164000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B3.63576374
2BRD43.31200586
3SCYL23.24042078
4EIF2AK13.06246648
5PBK2.78863820
6FGFR22.71371224
7STK392.68958016
8BRSK22.62901505
9PKN22.20998977
10MAP3K132.18526594
11TTK2.09597302
12ACVR1B2.09033073
13STK38L2.07424353
14TGFBR11.92403812
15EIF2AK31.90931064
16MKNK21.75995732
17ZAK1.73678285
18PLK41.69639301
19TAF11.65047431
20EPHA21.53721952
21ATR1.48689680
22NEK61.48405853
23SRPK11.45831760
24FGFR11.41662027
25MST41.36515451
26NEK91.36048704
27SIK11.33741478
28MELK1.32626844
29MAP3K21.27991525
30STK31.27506238
31CDK71.22711661
32CHEK21.20425817
33MAP3K71.17851578
34FRK1.12284323
35TNIK1.11413498
36CDC71.11395442
37MET1.10970695
38PLK11.08236590
39TLK11.04500329
40MKNK11.01346671
41RPS6KB21.01105804
42OXSR11.00861996
43SMG11.00691504
44CDK81.00317928
45LATS11.00069648
46LATS21.00002964
47MAP3K140.98318351
48WNK40.97252707
49NUAK10.96645010
50BRSK10.95588040
51CDK40.95510307
52CDK120.95495425
53NEK10.94056869
54TRIB30.94020116
55ATM0.89846880
56CDK60.88193776
57PRKCE0.87813881
58IRAK20.84964847
59PIK3CA0.84654164
60PASK0.84222967
61BUB10.82814294
62STK40.82776758
63AKT30.76619819
64AURKB0.76112298
65CHUK0.75885855
66VRK10.75482489
67CASK0.75446896
68CHEK10.75371988
69YES10.74805335
70FGFR40.73739592
71ICK0.71362652
72FGFR30.66754999
73MAP3K100.66052608
74BMX0.65789305
75WNK30.64211784
76ERBB40.63868788
77EPHA40.62784218
78ERBB30.61242458
79PLK30.60657768
80CCNB10.59494247
81MST1R0.59201712
82CLK10.58881839
83IRAK10.57684460
84PNCK0.57108223
85EIF2AK20.56988656
86CSF1R0.54922910
87NME20.54649946
88TYRO30.54610928
89CDK10.54061390
90VRK20.51766931
91CDK90.50315073
92MAP3K90.47924287
93LMTK20.47788783
94PRKDC0.45154720
95STK240.44777948
96RAF10.43602352
97CSNK1G10.43506878
98CDK20.42201711
99NLK0.40395474
100SGK30.37315137

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.11858549
2Fanconi anemia pathway_Homo sapiens_hsa034603.11467895
3DNA replication_Homo sapiens_hsa030303.04751103
4Homologous recombination_Homo sapiens_hsa034402.69599763
5Basal transcription factors_Homo sapiens_hsa030222.65496195
6Non-homologous end-joining_Homo sapiens_hsa034502.60368013
7Mismatch repair_Homo sapiens_hsa034302.59261638
8Nucleotide excision repair_Homo sapiens_hsa034202.50505261
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49381672
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.33905683
11Cell cycle_Homo sapiens_hsa041102.32864147
12RNA transport_Homo sapiens_hsa030132.21767121
13Thyroid cancer_Homo sapiens_hsa052162.08930181
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.81854866
15Systemic lupus erythematosus_Homo sapiens_hsa053221.78011321
16Spliceosome_Homo sapiens_hsa030401.75982765
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.74435116
18Vitamin B6 metabolism_Homo sapiens_hsa007501.52410984
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45473454
20mTOR signaling pathway_Homo sapiens_hsa041501.42830275
21Steroid biosynthesis_Homo sapiens_hsa001001.39399262
22Base excision repair_Homo sapiens_hsa034101.38854529
23N-Glycan biosynthesis_Homo sapiens_hsa005101.37755947
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32507902
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32311484
26RNA degradation_Homo sapiens_hsa030181.31425953
27Viral carcinogenesis_Homo sapiens_hsa052031.26636602
28Prostate cancer_Homo sapiens_hsa052151.26399491
29Alcoholism_Homo sapiens_hsa050341.23017749
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18755707
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17887594
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.12973255
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11496581
34mRNA surveillance pathway_Homo sapiens_hsa030151.11467899
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.10114503
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.07866211
37MicroRNAs in cancer_Homo sapiens_hsa052061.04887517
38ABC transporters_Homo sapiens_hsa020101.03277031
39Basal cell carcinoma_Homo sapiens_hsa052171.02236586
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00012668
41Chronic myeloid leukemia_Homo sapiens_hsa052200.99667938
42TGF-beta signaling pathway_Homo sapiens_hsa043500.96045513
43p53 signaling pathway_Homo sapiens_hsa041150.95375931
44Endometrial cancer_Homo sapiens_hsa052130.94529945
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94328064
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91846638
47Hedgehog signaling pathway_Homo sapiens_hsa043400.91500839
48Regulation of autophagy_Homo sapiens_hsa041400.90708509
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90439724
50Non-small cell lung cancer_Homo sapiens_hsa052230.90341254
51Fatty acid biosynthesis_Homo sapiens_hsa000610.88519042
52Protein export_Homo sapiens_hsa030600.87995198
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87617633
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86172263
55Propanoate metabolism_Homo sapiens_hsa006400.86093654
56Lysine degradation_Homo sapiens_hsa003100.84020798
57Small cell lung cancer_Homo sapiens_hsa052220.83429609
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82704474
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.76128198
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75315083
61Acute myeloid leukemia_Homo sapiens_hsa052210.74730639
62Hepatitis B_Homo sapiens_hsa051610.74412838
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74373423
64Oocyte meiosis_Homo sapiens_hsa041140.73120318
65Hippo signaling pathway_Homo sapiens_hsa043900.72663571
66Fatty acid metabolism_Homo sapiens_hsa012120.72267214
67Thyroid hormone synthesis_Homo sapiens_hsa049180.70924274
68B cell receptor signaling pathway_Homo sapiens_hsa046620.69782042
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68452755
70Peroxisome_Homo sapiens_hsa041460.66548567
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65852214
72Adherens junction_Homo sapiens_hsa045200.65410864
73Herpes simplex infection_Homo sapiens_hsa051680.62637901
74Melanoma_Homo sapiens_hsa052180.60765294
75Fructose and mannose metabolism_Homo sapiens_hsa000510.58368539
76Wnt signaling pathway_Homo sapiens_hsa043100.56826008
77Prolactin signaling pathway_Homo sapiens_hsa049170.56165051
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55235653
79Hepatitis C_Homo sapiens_hsa051600.54324144
80FoxO signaling pathway_Homo sapiens_hsa040680.53574976
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.53485472
82Sphingolipid metabolism_Homo sapiens_hsa006000.53165301
83ErbB signaling pathway_Homo sapiens_hsa040120.52518233
84Butanoate metabolism_Homo sapiens_hsa006500.50838876
85Retinol metabolism_Homo sapiens_hsa008300.50683987
86Proteoglycans in cancer_Homo sapiens_hsa052050.49190892
87Nitrogen metabolism_Homo sapiens_hsa009100.49063562
88Pancreatic cancer_Homo sapiens_hsa052120.48826684
89Colorectal cancer_Homo sapiens_hsa052100.46747531
90Glioma_Homo sapiens_hsa052140.45320045
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.44438538
92Insulin signaling pathway_Homo sapiens_hsa049100.43817288
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.43503273
94Renal cell carcinoma_Homo sapiens_hsa052110.43223055
95Carbon metabolism_Homo sapiens_hsa012000.43062063
96Circadian rhythm_Homo sapiens_hsa047100.42038090
97Biosynthesis of amino acids_Homo sapiens_hsa012300.41607777
98Pyruvate metabolism_Homo sapiens_hsa006200.41553600
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38182510
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36558314

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