ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.22275260
2	protein polyglutamylation (GO:0018095)	4.10941013
3	pyrimidine nucleobase catabolic process (GO:0006208)	3.81967994
4	epithelial cilium movement (GO:0003351)	3.78995282
5	behavioral response to nicotine (GO:0035095)	3.75728959
6	water-soluble vitamin biosynthetic process (GO:0042364)	3.67053969
7	intraciliary transport (GO:0042073)	3.57099323
8	protein localization to cilium (GO:0061512)	3.52827305
9	cellular ketone body metabolic process (GO:0046950)	3.48214660
10	presynaptic membrane assembly (GO:0097105)	3.37079100
11	nucleobase catabolic process (GO:0046113)	3.29990548
12	respiratory chain complex IV assembly (GO:0008535)	3.22821013
13	resolution of meiotic recombination intermediates (GO:0000712)	3.21699643
14	nonmotile primary cilium assembly (GO:0035058)	3.21235000
15	preassembly of GPI anchor in ER membrane (GO:0016254)	3.19667354
16	regulation of hexokinase activity (GO:1903299)	3.17924246
17	regulation of glucokinase activity (GO:0033131)	3.17924246
18	protein complex biogenesis (GO:0070271)	3.17078428
19	cilium assembly (GO:0042384)	3.16794621
20	cilium organization (GO:0044782)	3.15640957
21	cilium morphogenesis (GO:0060271)	3.14750669
22	positive regulation of mitochondrial fission (GO:0090141)	3.13715814
23	cilium movement (GO:0003341)	3.13434579
24	ketone body metabolic process (GO:1902224)	3.12953316
25	DNA double-strand break processing (GO:0000729)	3.11502066
26	neural tube formation (GO:0001841)	3.09360561
27	neuron fate determination (GO:0048664)	3.08848631
28	regulation of cilium movement (GO:0003352)	3.07464518
29	fucose catabolic process (GO:0019317)	3.05382244
30	L-fucose metabolic process (GO:0042354)	3.05382244
31	L-fucose catabolic process (GO:0042355)	3.05382244
32	retinal ganglion cell axon guidance (GO:0031290)	3.02705371
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.99338762
34	NADH dehydrogenase complex assembly (GO:0010257)	2.99338762
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.99338762
36	axoneme assembly (GO:0035082)	2.98800476
37	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.98083029
38	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.98083029
39	mitochondrial respiratory chain complex assembly (GO:0033108)	2.94920885
40	platelet dense granule organization (GO:0060155)	2.94194909
41	spinal cord motor neuron differentiation (GO:0021522)	2.90819908
42	detection of light stimulus involved in visual perception (GO:0050908)	2.88770451
43	detection of light stimulus involved in sensory perception (GO:0050962)	2.88770451
44	cytochrome complex assembly (GO:0017004)	2.86422933
45	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.83117355
46	presynaptic membrane organization (GO:0097090)	2.77671736
47	GPI anchor metabolic process (GO:0006505)	2.72404055
48	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.72094281
49	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.72094281
50	peptidyl-histidine modification (GO:0018202)	2.71667968
51	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.69980037
52	gamma-aminobutyric acid transport (GO:0015812)	2.67958341
53	synapsis (GO:0007129)	2.64217017
54	indolalkylamine metabolic process (GO:0006586)	2.62407034
55	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.62055618
56	regulation of telomere maintenance (GO:0032204)	2.58375529
57	neuron cell-cell adhesion (GO:0007158)	2.57598438
58	regulation of action potential (GO:0098900)	2.57110533
59	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.56565752
60	protein-cofactor linkage (GO:0018065)	2.55749522
61	cullin deneddylation (GO:0010388)	2.55271962
62	olfactory bulb development (GO:0021772)	2.53705273
63	cornea development in camera-type eye (GO:0061303)	2.53425193
64	photoreceptor cell maintenance (GO:0045494)	2.53080115
65	glycosphingolipid biosynthetic process (GO:0006688)	2.52982244
66	inositol phosphate catabolic process (GO:0071545)	2.51359911
67	behavioral response to ethanol (GO:0048149)	2.50954648
68	dendritic spine morphogenesis (GO:0060997)	2.50897408
69	somite development (GO:0061053)	2.50722163
70	cellular component assembly involved in morphogenesis (GO:0010927)	2.48819948
71	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.48571198
72	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.46603097
73	photoreceptor cell development (GO:0042461)	2.46408226
74	C-terminal protein amino acid modification (GO:0018410)	2.45542777
75	anterograde synaptic vesicle transport (GO:0048490)	2.45407307
76	S-adenosylmethionine metabolic process (GO:0046500)	2.44555568
77	adenosine metabolic process (GO:0046085)	2.44402088
78	hindbrain development (GO:0030902)	2.44225666
79	C-terminal protein lipidation (GO:0006501)	2.43387551
80	single strand break repair (GO:0000012)	2.42729446
81	proline transport (GO:0015824)	2.42674878
82	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.42622957
83	neuronal action potential (GO:0019228)	2.41785434
84	postsynaptic membrane organization (GO:0001941)	2.41557801
85	regulation of development, heterochronic (GO:0040034)	2.41292290
86	protein K11-linked deubiquitination (GO:0035871)	2.40999130
87	negative regulation of telomere maintenance (GO:0032205)	2.40824463
88	anterograde axon cargo transport (GO:0008089)	2.40123590
89	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.39451789
90	acrosome reaction (GO:0007340)	2.38903438
91	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.38462528
92	transmission of nerve impulse (GO:0019226)	2.36303933
93	GPI anchor biosynthetic process (GO:0006506)	2.35801349
94	regulation of timing of cell differentiation (GO:0048505)	2.35761934
95	adult feeding behavior (GO:0008343)	2.35678577
96	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.34353543
97	ATP synthesis coupled proton transport (GO:0015986)	2.33731230
98	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.33731230
99	startle response (GO:0001964)	2.33425857
100	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.32809784

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.42739006
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.07004405
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.05612507
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.89906406
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.79739522
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.77857795
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.74115348
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.69788254
9	VDR_22108803_ChIP-Seq_LS180_Human	2.50903988
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.50644585
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.41845736
12	FUS_26573619_Chip-Seq_HEK293_Human	2.31815691
13	EWS_26573619_Chip-Seq_HEK293_Human	2.22895839
14	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.20435404
15	P300_19829295_ChIP-Seq_ESCs_Human	2.12436878
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.10796271
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10325437
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.99357964
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.98686898
20	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.98365232
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.94078036
22	* MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93363321
23	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.85918134
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.80304050
25	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.77876194
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.72799064
27	* EST1_17652178_ChIP-ChIP_JURKAT_Human	1.71264606
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.69868971
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68068166
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.63018193
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58958323
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.58615734
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58615734
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.58225896
35	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.57274870
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56338132
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.54494625
38	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.54332309
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.53253306
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.52247586
41	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.51448772
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49122391
43	AR_25329375_ChIP-Seq_VCAP_Human	1.44478878
44	RNF2_27304074_Chip-Seq_NSC_Mouse	1.44477012
45	IRF1_19129219_ChIP-ChIP_H3396_Human	1.44347159
46	* STAT3_23295773_ChIP-Seq_U87_Human	1.42725510
47	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.42473185
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40882504
49	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40848433
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39279097
51	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.37550486
52	BCAT_22108803_ChIP-Seq_LS180_Human	1.36720853
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35408259
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35117749
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.34579681
56	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31889653
57	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31641959
58	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31210618
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.29404624
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.29266107
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26024465
62	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.24439939
63	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.23568830
64	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23568830
65	TCF4_23295773_ChIP-Seq_U87_Human	1.22735330
66	REST_21632747_ChIP-Seq_MESCs_Mouse	1.22189769
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.21742198
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21214623
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20915762
70	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20891290
71	VDR_23849224_ChIP-Seq_CD4+_Human	1.20169637
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20145718
73	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.17100688
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17039262
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16807264
76	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.14359599
77	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.13753840
78	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.13606068
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09565769
80	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09565769
81	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.08186439
82	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.07750797
83	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06134802
84	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.05592836
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05295844
86	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04471143
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03254091
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03093536
89	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03093536
90	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.02807244
91	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01425253
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01191083
93	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.01014070
94	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00047302
95	NCOR_22424771_ChIP-Seq_293T_Human	0.99726891
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99477336
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98893224
98	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98667407
99	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.97406935
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.96617568

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.03010330
2	MP0003787_abnormal_imprinting	2.98143504
3	MP0003122_maternal_imprinting	2.58253618
4	MP0002102_abnormal_ear_morphology	2.53386871
5	MP0000569_abnormal_digit_pigmentation	2.50567056
6	MP0003121_genomic_imprinting	2.41317411
7	MP0003880_abnormal_central_pattern	2.40381493
8	MP0006072_abnormal_retinal_apoptosis	2.31966556
9	MP0001529_abnormal_vocalization	2.21742435
10	MP0002837_dystrophic_cardiac_calcinosis	2.17415400
11	MP0006276_abnormal_autonomic_nervous	2.04308644
12	MP0005551_abnormal_eye_electrophysiolog	2.02304085
13	MP0001968_abnormal_touch/_nociception	1.97008409
14	MP0001984_abnormal_olfaction	1.90377764
15	MP0009046_muscle_twitch	1.83597239
16	MP0004142_abnormal_muscle_tone	1.78741973
17	MP0005253_abnormal_eye_physiology	1.75983652
18	MP0009745_abnormal_behavioral_response	1.73913005
19	MP0003011_delayed_dark_adaptation	1.71381859
20	MP0005645_abnormal_hypothalamus_physiol	1.69552885
21	MP0002638_abnormal_pupillary_reflex	1.69552576
22	MP0001486_abnormal_startle_reflex	1.69007771
23	MP0002938_white_spotting	1.68591277
24	MP0002736_abnormal_nociception_after	1.67173885
25	MP0006292_abnormal_olfactory_placode	1.63297856
26	MP0002272_abnormal_nervous_system	1.62645821
27	MP0004133_heterotaxia	1.62561056
28	MP0008058_abnormal_DNA_repair	1.59404190
29	MP0005646_abnormal_pituitary_gland	1.58860510
30	MP0002751_abnormal_autonomic_nervous	1.57074192
31	MP0003195_calcinosis	1.53904841
32	MP0008995_early_reproductive_senescence	1.51524494
33	MP0004147_increased_porphyrin_level	1.49454400
34	MP0001986_abnormal_taste_sensitivity	1.48686798
35	MP0008789_abnormal_olfactory_epithelium	1.47272034
36	MP0000631_abnormal_neuroendocrine_gland	1.47255862
37	MP0009780_abnormal_chondrocyte_physiolo	1.46009847
38	MP0004885_abnormal_endolymph	1.43556323
39	MP0000778_abnormal_nervous_system	1.42930744
40	MP0002653_abnormal_ependyma_morphology	1.42097718
41	MP0005084_abnormal_gallbladder_morpholo	1.41266319
42	MP0002064_seizures	1.37189664
43	MP0002735_abnormal_chemical_nociception	1.34797437
44	MP0005499_abnormal_olfactory_system	1.34055774
45	MP0005394_taste/olfaction_phenotype	1.34055774
46	MP0005379_endocrine/exocrine_gland_phen	1.33487637
47	MP0004924_abnormal_behavior	1.32792017
48	MP0005386_behavior/neurological_phenoty	1.32792017
49	MP0002163_abnormal_gland_morphology	1.31735271
50	MP0002557_abnormal_social/conspecific_i	1.31392241
51	MP0002572_abnormal_emotion/affect_behav	1.29400778
52	MP0003635_abnormal_synaptic_transmissio	1.19912019
53	MP0001501_abnormal_sleep_pattern	1.18486673
54	MP0002067_abnormal_sensory_capabilities	1.17713923
55	MP0002734_abnormal_mechanical_nocicepti	1.17516053
56	MP0004270_analgesia	1.17361232
57	MP0010386_abnormal_urinary_bladder	1.13315001
58	MP0005174_abnormal_tail_pigmentation	1.12082256
59	MP0005423_abnormal_somatic_nervous	1.12043776
60	MP0006054_spinal_hemorrhage	1.10760650
61	MP0002909_abnormal_adrenal_gland	1.10069730
62	MP0001485_abnormal_pinna_reflex	1.09847160
63	MP0005410_abnormal_fertilization	1.07735814
64	MP0002063_abnormal_learning/memory/cond	1.06961124
65	MP0001970_abnormal_pain_threshold	1.05870188
66	MP0002160_abnormal_reproductive_system	1.05771488
67	MP0004043_abnormal_pH_regulation	1.04359683
68	MP0003698_abnormal_male_reproductive	1.02444322
69	MP0000647_abnormal_sebaceous_gland	1.02154976
70	MP0002822_catalepsy	1.01910474
71	MP0002254_reproductive_system_inflammat	1.00064107
72	MP0005389_reproductive_system_phenotype	0.99683024
73	MP0003890_abnormal_embryonic-extraembry	0.97206536
74	MP0001764_abnormal_homeostasis	0.96990514
75	MP0008872_abnormal_physiological_respon	0.96687089
76	MP0001929_abnormal_gametogenesis	0.96628874
77	MP0002184_abnormal_innervation	0.96494742
78	MP0000372_irregular_coat_pigmentation	0.95174056
79	MP0005195_abnormal_posterior_eye	0.94960893
80	MP0000955_abnormal_spinal_cord	0.94685651
81	MP0002095_abnormal_skin_pigmentation	0.94572931
82	MP0003646_muscle_fatigue	0.94262540
83	MP0001293_anophthalmia	0.94153232
84	MP0002928_abnormal_bile_duct	0.93419201
85	MP0001188_hyperpigmentation	0.92847515
86	MP0001905_abnormal_dopamine_level	0.92702644
87	MP0001919_abnormal_reproductive_system	0.92660545
88	MP0004215_abnormal_myocardial_fiber	0.91749332
89	MP0002733_abnormal_thermal_nociception	0.91624438
90	MP0002752_abnormal_somatic_nervous	0.90637604
91	MP0005367_renal/urinary_system_phenotyp	0.88228837
92	MP0000516_abnormal_urinary_system	0.88228837
93	MP0003137_abnormal_impulse_conducting	0.88205322
94	MP0004145_abnormal_muscle_electrophysio	0.87401293
95	MP0003718_maternal_effect	0.86440551
96	MP0004742_abnormal_vestibular_system	0.85182968
97	MP0008875_abnormal_xenobiotic_pharmacok	0.84152062
98	MP0002882_abnormal_neuron_morphology	0.83560731
99	MP0003567_abnormal_fetal_cardiomyocyte	0.82872152
100	MP0002210_abnormal_sex_determination	0.82355041

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.28632957
2	Pancreatic cysts (HP:0001737)	4.18908881
3	Pancreatic fibrosis (HP:0100732)	4.18267343
4	Abnormality of midbrain morphology (HP:0002418)	3.50564383
5	Molar tooth sign on MRI (HP:0002419)	3.50564383
6	Nephronophthisis (HP:0000090)	3.45042343
7	Medial flaring of the eyebrow (HP:0010747)	3.42245728
8	Methylmalonic acidemia (HP:0002912)	3.30683149
9	Gait imbalance (HP:0002141)	3.05073660
10	Congenital primary aphakia (HP:0007707)	2.94165135
11	Type II lissencephaly (HP:0007260)	2.90722681
12	Chronic hepatic failure (HP:0100626)	2.87377381
13	Abnormality of the renal medulla (HP:0100957)	2.86987731
14	Nephrogenic diabetes insipidus (HP:0009806)	2.85338373
15	Congenital stationary night blindness (HP:0007642)	2.79579124
16	Methylmalonic aciduria (HP:0012120)	2.69244428
17	Polyphagia (HP:0002591)	2.63262238
18	Focal motor seizures (HP:0011153)	2.60825756
19	Acute necrotizing encephalopathy (HP:0006965)	2.56601047
20	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.55660000
21	Genital tract atresia (HP:0001827)	2.54049672
22	Abnormality of the renal cortex (HP:0011035)	2.49277893
23	Cystic liver disease (HP:0006706)	2.48978238
24	Lissencephaly (HP:0001339)	2.47748146
25	Cerebellar dysplasia (HP:0007033)	2.43640821
26	Hyperventilation (HP:0002883)	2.42864687
27	Postaxial foot polydactyly (HP:0001830)	2.42599270
28	Vaginal atresia (HP:0000148)	2.41161513
29	Colon cancer (HP:0003003)	2.37745621
30	Progressive inability to walk (HP:0002505)	2.35137939
31	Renal cortical cysts (HP:0000803)	2.34781791
32	Abnormality of vitamin B metabolism (HP:0004340)	2.32950186
33	Male pseudohermaphroditism (HP:0000037)	2.31173096
34	Progressive macrocephaly (HP:0004481)	2.28949485
35	Broad-based gait (HP:0002136)	2.28895197
36	Abolished electroretinogram (ERG) (HP:0000550)	2.28604844
37	Sclerocornea (HP:0000647)	2.28187054
38	Volvulus (HP:0002580)	2.25851017
39	Anencephaly (HP:0002323)	2.23224999
40	Acute encephalopathy (HP:0006846)	2.21887576
41	Hemiparesis (HP:0001269)	2.19559472
42	Mitochondrial inheritance (HP:0001427)	2.19223189
43	Occipital encephalocele (HP:0002085)	2.18189644
44	Hyperglycinemia (HP:0002154)	2.17684357
45	Abnormality of the labia minora (HP:0012880)	2.16222145
46	Inability to walk (HP:0002540)	2.16097365
47	Poor coordination (HP:0002370)	2.15730060
48	Drooling (HP:0002307)	2.12141498
49	Abnormal mitochondria in muscle tissue (HP:0008316)	2.12118015
50	Fair hair (HP:0002286)	2.11447850
51	Abnormal ciliary motility (HP:0012262)	2.10938555
52	Postaxial hand polydactyly (HP:0001162)	2.09192190
53	Abnormal respiratory epithelium morphology (HP:0012253)	2.07820044
54	Abnormal respiratory motile cilium morphology (HP:0005938)	2.07820044
55	Narrow forehead (HP:0000341)	2.06272252
56	Tubulointerstitial nephritis (HP:0001970)	2.06112866
57	Attenuation of retinal blood vessels (HP:0007843)	2.03238136
58	Increased CSF lactate (HP:0002490)	2.02851559
59	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.02061070
60	Bile duct proliferation (HP:0001408)	2.01164960
61	Abnormal biliary tract physiology (HP:0012439)	2.01164960
62	Retinal dysplasia (HP:0007973)	2.00138914
63	Congenital hepatic fibrosis (HP:0002612)	1.98792410
64	Furrowed tongue (HP:0000221)	1.97805480
65	Hypothermia (HP:0002045)	1.97725634
66	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.97438995
67	Gaze-evoked nystagmus (HP:0000640)	1.97028489
68	Abnormal rod and cone electroretinograms (HP:0008323)	1.95602913
69	Bony spicule pigmentary retinopathy (HP:0007737)	1.94515604
70	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.93207289
71	Absent/shortened dynein arms (HP:0200106)	1.93207289
72	Absent speech (HP:0001344)	1.92571990
73	Intestinal atresia (HP:0011100)	1.92371615
74	Dialeptic seizures (HP:0011146)	1.89314023
75	Excessive salivation (HP:0003781)	1.87813103
76	Febrile seizures (HP:0002373)	1.86247920
77	Optic disc pallor (HP:0000543)	1.84327086
78	Focal seizures (HP:0007359)	1.84020676
79	Ketoacidosis (HP:0001993)	1.83496683
80	Polyuria (HP:0000103)	1.83176767
81	Pachygyria (HP:0001302)	1.82228501
82	Tubular atrophy (HP:0000092)	1.81503561
83	Polydipsia (HP:0001959)	1.81000180
84	Abnormal drinking behavior (HP:0030082)	1.81000180
85	Optic nerve hypoplasia (HP:0000609)	1.78395994
86	Increased hepatocellular lipid droplets (HP:0006565)	1.77264367
87	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77090367
88	Short tibia (HP:0005736)	1.75113824
89	Specific learning disability (HP:0001328)	1.74323005
90	Hepatic necrosis (HP:0002605)	1.74236945
91	Astigmatism (HP:0000483)	1.72418118
92	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.72336743
93	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.72336743
94	Broad foot (HP:0001769)	1.71939258
95	Lipid accumulation in hepatocytes (HP:0006561)	1.70342624
96	Abnormal respiratory motile cilium physiology (HP:0012261)	1.69871252
97	Abnormality of macular pigmentation (HP:0008002)	1.69656506
98	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.68711570
99	Ketosis (HP:0001946)	1.68505485
100	Aplasia/hypoplasia of the uterus (HP:0008684)	1.68285761

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.71008137
2	MAP4K2	3.58982238
3	WNK3	3.04665063
4	PINK1	2.80511917
5	MARK1	2.74460845
6	CASK	2.50881091
7	MAPK13	2.43290753
8	MAP3K4	2.30092935
9	TRIM28	2.22192509
10	ADRBK2	2.19522792
11	MAP3K9	1.99388561
12	NEK1	1.96713656
13	BMPR1B	1.94331859
14	GRK1	1.77874284
15	ZAK	1.77350949
16	INSRR	1.76396839
17	BCR	1.73295712
18	MAP2K7	1.70874057
19	NUAK1	1.68265006
20	TAOK3	1.62608916
21	CSNK1G1	1.60337517
22	PLK2	1.49722442
23	CSNK1G3	1.46484209
24	PNCK	1.43026138
25	CSNK1G2	1.40631374
26	EIF2AK3	1.40625992
27	DYRK2	1.40566391
28	ERBB3	1.39540951
29	CSNK1A1L	1.30128173
30	ACVR1B	1.29558691
31	TNIK	1.28238503
32	PAK3	1.28174566
33	NTRK3	1.27894720
34	SRPK1	1.21684259
35	EPHA3	1.16416171
36	WNK4	1.15712234
37	BCKDK	1.14716137
38	OXSR1	1.07398500
39	MKNK2	1.06687332
40	DYRK3	1.04989746
41	PRKCE	0.98722761
42	VRK1	0.95692515
43	CAMKK2	0.95331238
44	PRKCG	0.94776162
45	MKNK1	0.90032299
46	NTRK2	0.82751477
47	PLK3	0.80049213
48	PLK4	0.79108721
49	STK39	0.78279836
50	RPS6KA4	0.74381673
51	TXK	0.70169704
52	UHMK1	0.70022879
53	TGFBR1	0.68757314
54	MINK1	0.68115014
55	CDK19	0.66993829
56	CAMK2A	0.65647292
57	EPHA4	0.65101534
58	MST4	0.64294444
59	DAPK2	0.64001375
60	TLK1	0.63082930
61	PHKG2	0.61443830
62	PHKG1	0.61443830
63	OBSCN	0.61010440
64	NLK	0.59438246
65	STK38L	0.59420091
66	FGFR2	0.57367766
67	TSSK6	0.56966765
68	MAPKAPK5	0.52233783
69	FER	0.51574100
70	TNK2	0.51511322
71	WEE1	0.50880070
72	CSNK1A1	0.49704813
73	MAP3K2	0.49438623
74	ADRBK1	0.48725082
75	KSR1	0.47829358
76	TAF1	0.47106797
77	FLT3	0.47032715
78	PLK1	0.46358184
79	PRKACA	0.46243234
80	EPHB2	0.44218789
81	SGK2	0.42992707
82	NEK2	0.41402312
83	PRKACB	0.41134178
84	MAP2K4	0.39669583
85	CAMK1	0.39083766
86	RPS6KA5	0.38795044
87	DYRK1A	0.38334694
88	PKN1	0.38017063
89	BUB1	0.37875440
90	PRKD3	0.37842435
91	ATM	0.37748352
92	CSNK1D	0.37551909
93	BRSK2	0.37228356
94	CAMK4	0.37035114
95	MAPK15	0.36599188
96	GRK7	0.36274813
97	PASK	0.35821049
98	PRKG1	0.35755260
99	CDK5	0.34724976
100	CCNB1	0.34034785

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.28836847
2	Protein export_Homo sapiens_hsa03060	3.25641872
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.65958958
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.58837543
5	Butanoate metabolism_Homo sapiens_hsa00650	2.37375586
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.29204841
7	Basal transcription factors_Homo sapiens_hsa03022	2.28664443
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.21917199
9	Nicotine addiction_Homo sapiens_hsa05033	2.20953793
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.17221789
11	Parkinsons disease_Homo sapiens_hsa05012	2.14304270
12	Phototransduction_Homo sapiens_hsa04744	2.13675954
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.13130510
14	Propanoate metabolism_Homo sapiens_hsa00640	2.05037058
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.90102870
16	Homologous recombination_Homo sapiens_hsa03440	1.79597118
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.78214483
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.76599040
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57631253
20	RNA degradation_Homo sapiens_hsa03018	1.51840812
21	Steroid biosynthesis_Homo sapiens_hsa00100	1.49825340
22	RNA polymerase_Homo sapiens_hsa03020	1.49001421
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.47271861
24	Huntingtons disease_Homo sapiens_hsa05016	1.45530175
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.43731600
26	Taste transduction_Homo sapiens_hsa04742	1.42649852
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.42395198
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.40769053
29	GABAergic synapse_Homo sapiens_hsa04727	1.39251999
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.37534824
31	Alzheimers disease_Homo sapiens_hsa05010	1.37353437
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.36149774
33	Peroxisome_Homo sapiens_hsa04146	1.32922188
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.30633193
35	Collecting duct acid secretion_Homo sapiens_hsa04966	1.30387679
36	Regulation of autophagy_Homo sapiens_hsa04140	1.27587844
37	Morphine addiction_Homo sapiens_hsa05032	1.20342039
38	Mismatch repair_Homo sapiens_hsa03430	1.18776499
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.16907113
40	Cardiac muscle contraction_Homo sapiens_hsa04260	1.15926673
41	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.15510851
42	Circadian entrainment_Homo sapiens_hsa04713	1.09856345
43	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.05740098
44	Serotonergic synapse_Homo sapiens_hsa04726	1.03876340
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.03691930
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.99745381
47	Glutamatergic synapse_Homo sapiens_hsa04724	0.99269039
48	Proteasome_Homo sapiens_hsa03050	0.96606332
49	Folate biosynthesis_Homo sapiens_hsa00790	0.95226523
50	Olfactory transduction_Homo sapiens_hsa04740	0.93229379
51	Insulin secretion_Homo sapiens_hsa04911	0.91562548
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86228472
53	Purine metabolism_Homo sapiens_hsa00230	0.85697873
54	Cocaine addiction_Homo sapiens_hsa05030	0.84688328
55	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.82879841
56	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.81035047
57	Dopaminergic synapse_Homo sapiens_hsa04728	0.80253886
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.79849666
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79169275
60	Caffeine metabolism_Homo sapiens_hsa00232	0.78056075
61	Sulfur metabolism_Homo sapiens_hsa00920	0.77380301
62	Retinol metabolism_Homo sapiens_hsa00830	0.75207342
63	Metabolic pathways_Homo sapiens_hsa01100	0.74977675
64	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.74960402
65	Fatty acid elongation_Homo sapiens_hsa00062	0.74403786
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.74203168
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73963484
68	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.72788254
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.72545988
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72158342
71	Amphetamine addiction_Homo sapiens_hsa05031	0.67684511
72	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67038490
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66988871
74	One carbon pool by folate_Homo sapiens_hsa00670	0.64185345
75	RNA transport_Homo sapiens_hsa03013	0.59323592
76	Fatty acid degradation_Homo sapiens_hsa00071	0.59316643
77	Long-term depression_Homo sapiens_hsa04730	0.57922635
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.57312006
79	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55968528
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55359807
81	Fatty acid metabolism_Homo sapiens_hsa01212	0.53551037
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53388601
83	Circadian rhythm_Homo sapiens_hsa04710	0.53263735
84	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.53003164
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51103448
86	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.50923204
87	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.50880602
88	Base excision repair_Homo sapiens_hsa03410	0.49721528
89	ABC transporters_Homo sapiens_hsa02010	0.47314347
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.42686515
91	Glutathione metabolism_Homo sapiens_hsa00480	0.42430183
92	Lysine degradation_Homo sapiens_hsa00310	0.40246010
93	Salivary secretion_Homo sapiens_hsa04970	0.38990346
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.38469542
95	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.36048609
96	Oocyte meiosis_Homo sapiens_hsa04114	0.35753007
97	Cholinergic synapse_Homo sapiens_hsa04725	0.35049324
98	Axon guidance_Homo sapiens_hsa04360	0.34072025
99	Spliceosome_Homo sapiens_hsa03040	0.33994885
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.33521024

ZNF573

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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