ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.14249619
2	base-excision repair, AP site formation (GO:0006285)	4.54278561
3	piRNA metabolic process (GO:0034587)	4.31366589
4	pyrimidine nucleotide catabolic process (GO:0006244)	4.28501215
5	peptidyl-arginine omega-N-methylation (GO:0035247)	4.18032465
6	metallo-sulfur cluster assembly (GO:0031163)	4.01576951
7	iron-sulfur cluster assembly (GO:0016226)	4.01576951
8	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.90907088
9	DNA strand elongation (GO:0022616)	3.87742843
10	histone arginine methylation (GO:0034969)	3.84389904
11	DNA strand elongation involved in DNA replication (GO:0006271)	3.82508264
12	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.79337105
13	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.76824696
14	base-excision repair (GO:0006284)	3.75422901
15	mitotic chromosome condensation (GO:0007076)	3.75402690
16	regulation of chromatin binding (GO:0035561)	3.74822909
17	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.67627531
18	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.62021194
19	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.58455385
20	spliceosomal tri-snRNP complex assembly (GO:0000244)	3.55410413
21	DNA methylation involved in gamete generation (GO:0043046)	3.54032994
22	regulation of mitochondrial translation (GO:0070129)	3.53625655
23	telomere maintenance via semi-conservative replication (GO:0032201)	3.51085428
24	nucleosome disassembly (GO:0006337)	3.43175371
25	protein-DNA complex disassembly (GO:0032986)	3.43175371
26	chromatin assembly (GO:0031497)	3.39062791
27	deoxyribonucleotide catabolic process (GO:0009264)	3.34816319
28	peptidyl-arginine methylation (GO:0018216)	3.34345189
29	peptidyl-arginine N-methylation (GO:0035246)	3.34345189
30	negative regulation of mRNA processing (GO:0050686)	3.28476343
31	pseudouridine synthesis (GO:0001522)	3.27359696
32	tRNA methylation (GO:0030488)	3.25384572
33	DNA synthesis involved in DNA repair (GO:0000731)	3.18390122
34	DNA replication initiation (GO:0006270)	3.17312725
35	synaptonemal complex assembly (GO:0007130)	3.15532421
36	protein insertion into membrane (GO:0051205)	3.14078959
37	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.09989808
38	DNA unwinding involved in DNA replication (GO:0006268)	3.09006700
39	ribosome biogenesis (GO:0042254)	3.07410406
40	deoxyribose phosphate catabolic process (GO:0046386)	3.07057789
41	regulation of histone H3-K9 methylation (GO:0051570)	3.05885514
42	ncRNA 3-end processing (GO:0043628)	3.02524420
43	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.01614483
44	intracellular estrogen receptor signaling pathway (GO:0030520)	2.96447508
45	DNA replication-dependent nucleosome assembly (GO:0006335)	2.96440778
46	DNA replication-dependent nucleosome organization (GO:0034723)	2.96440778
47	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.92284930
48	negative regulation of histone methylation (GO:0031061)	2.91739035
49	mitotic metaphase plate congression (GO:0007080)	2.91541798
50	negative regulation of RNA splicing (GO:0033119)	2.90728917
51	male meiosis I (GO:0007141)	2.88885316
52	formation of translation preinitiation complex (GO:0001731)	2.87942572
53	rRNA transcription (GO:0009303)	2.86128828
54	establishment of integrated proviral latency (GO:0075713)	2.86046960
55	negative regulation of mRNA metabolic process (GO:1903312)	2.85333803
56	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.84847383
57	DNA replication checkpoint (GO:0000076)	2.84083670
58	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	2.82508956
59	mitotic nuclear envelope disassembly (GO:0007077)	2.81742783
60	protein localization to chromosome, centromeric region (GO:0071459)	2.81697595
61	negative regulation of Notch signaling pathway (GO:0045746)	2.81661341
62	DNA alkylation (GO:0006305)	2.81176999
63	DNA methylation (GO:0006306)	2.81176999
64	snRNA metabolic process (GO:0016073)	2.80542444
65	spliceosomal snRNP assembly (GO:0000387)	2.79829803
66	mitochondrial RNA metabolic process (GO:0000959)	2.76255171
67	telomere maintenance via telomere lengthening (GO:0010833)	2.75749747
68	binding of sperm to zona pellucida (GO:0007339)	2.75489904
69	establishment of viral latency (GO:0019043)	2.74616519
70	meiotic nuclear division (GO:0007126)	2.73886085
71	meiosis I (GO:0007127)	2.73826653
72	dosage compensation (GO:0007549)	2.72264207
73	heterochromatin organization (GO:0070828)	2.71911318
74	RNA localization (GO:0006403)	2.69489906
75	chromosome organization involved in meiosis (GO:0070192)	2.68393763
76	mRNA export from nucleus (GO:0006406)	2.67493059
77	peptidyl-arginine modification (GO:0018195)	2.67169135
78	positive regulation of mitochondrial fission (GO:0090141)	2.67033227
79	termination of RNA polymerase II transcription (GO:0006369)	2.65673033
80	pyrimidine dimer repair (GO:0006290)	2.63186967
81	chromatin assembly or disassembly (GO:0006333)	2.62614874
82	membrane disassembly (GO:0030397)	2.61584046
83	nuclear envelope disassembly (GO:0051081)	2.61584046
84	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.60881026
85	viral mRNA export from host cell nucleus (GO:0046784)	2.59848403
86	RNA export from nucleus (GO:0006405)	2.59822091
87	regulation of spindle checkpoint (GO:0090231)	2.57917765
88	synaptonemal complex organization (GO:0070193)	2.57876054
89	telomere maintenance via recombination (GO:0000722)	2.57819816
90	mitochondrial fusion (GO:0008053)	2.57611924
91	pentose metabolic process (GO:0019321)	2.54224215
92	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.53067474
93	mitotic nuclear envelope reassembly (GO:0007084)	2.53026044
94	nuclear envelope reassembly (GO:0031468)	2.53026044
95	histone H2A acetylation (GO:0043968)	2.52294097
96	protein localization to chromosome (GO:0034502)	2.51976640
97	tRNA modification (GO:0006400)	2.51924537
98	mitotic recombination (GO:0006312)	2.51635156
99	mitotic sister chromatid segregation (GO:0000070)	2.51454267
100	transcription-coupled nucleotide-excision repair (GO:0006283)	2.50512527

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.37282409
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.36277370
3	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.17706143
4	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.10659022
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.08542332
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.81636933
7	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.79017356
8	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.78178778
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.72620021
10	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.49435256
11	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.49312273
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.46292251
13	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.42937820
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.42680918
15	VDR_21846776_ChIP-Seq_THP-1_Human	2.29144117
16	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.28203064
17	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	2.21986926
18	XRN2_22483619_ChIP-Seq_HELA_Human	2.21829443
19	GABP_19822575_ChIP-Seq_HepG2_Human	2.13627705
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.11609272
21	MYC_22102868_ChIP-Seq_BL_Human	2.09480984
22	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.05811396
23	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.04543356
24	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.04147245
25	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.98302400
26	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.90758001
27	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.88682616
28	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.86791070
29	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.85960837
30	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.85210868
31	KDM5A_27292631_Chip-Seq_BREAST_Human	1.79913987
32	DCP1A_22483619_ChIP-Seq_HELA_Human	1.78794482
33	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.78561553
34	CIITA_25753668_ChIP-Seq_RAJI_Human	1.77575681
35	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.77127514
36	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.73071315
37	TTF2_22483619_ChIP-Seq_HELA_Human	1.70318349
38	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.68311417
39	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.66230079
40	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.64861394
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.60271418
42	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.59609661
43	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.56439765
44	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.55495211
45	FOXP3_21729870_ChIP-Seq_TREG_Human	1.53643013
46	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.50206982
47	P68_20966046_ChIP-Seq_HELA_Human	1.49076845
48	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.45854926
49	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.44246898
50	VDR_23849224_ChIP-Seq_CD4+_Human	1.43601909
51	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.41241279
52	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.41129229
53	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.38961682
54	* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.37647069
55	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.36459766
56	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.35088512
57	* LXR_22292898_ChIP-Seq_THP-1_Human	1.31577840
58	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.31055175
59	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.28901429
60	BCL6_27268052_Chip-Seq_Bcells_Human	1.28889449
61	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.28561084
62	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27923798
63	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.27552197
64	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.27003136
65	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.26031442
66	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.24564365
67	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.23108402
68	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.22933033
69	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.22398155
70	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.21372900
71	BCOR_27268052_Chip-Seq_Bcells_Human	1.19149793
72	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.16982304
73	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.16508078
74	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.16143240
75	PHF8_20622854_ChIP-Seq_HELA_Human	1.15686430
76	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.14707174
77	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.12608476
78	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.12508451
79	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.12401029
80	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.12000166
81	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.10792795
82	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.10729703
83	ZNF263_19887448_ChIP-Seq_K562_Human	1.10513054
84	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.10102335
85	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.09404117
86	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.09139288
87	MAF_26560356_Chip-Seq_TH2_Human	1.06341554
88	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.04750683
89	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.02093905
90	KDM2B_26808549_Chip-Seq_DND41_Human	1.01748430
91	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.99862559
92	CTCF_21964334_Chip-Seq_Bcells_Human	0.99190904
93	RACK7_27058665_Chip-Seq_MCF-7_Human	0.97522760
94	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.97267822
95	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.97061388
96	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.95408749
97	E2F1_20622854_ChIP-Seq_HELA_Human	0.94784635
98	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.93612840
99	SMC4_20622854_ChIP-Seq_HELA_Human	0.93592392
100	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.91684869

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	4.37890012
2	MP0008058_abnormal_DNA_repair	3.78198911
3	MP0003111_abnormal_nucleus_morphology	3.64869140
4	MP0008877_abnormal_DNA_methylation	3.47134613
5	MP0010094_abnormal_chromosome_stability	3.24938701
6	MP0009278_abnormal_bone_marrow	2.98833248
7	MP0008789_abnormal_olfactory_epithelium	2.84939926
8	MP0003718_maternal_effect	2.75077281
9	MP0003077_abnormal_cell_cycle	2.70880516
10	MP0005499_abnormal_olfactory_system	2.51358368
11	MP0005394_taste/olfaction_phenotype	2.51358368
12	MP0010030_abnormal_orbit_morphology	2.47389508
13	MP0001545_abnormal_hematopoietic_system	2.29309726
14	MP0005397_hematopoietic_system_phenotyp	2.29309726
15	MP0004957_abnormal_blastocyst_morpholog	2.28922555
16	MP0008932_abnormal_embryonic_tissue	2.28181825
17	MP0006035_abnormal_mitochondrial_morpho	2.05341426
18	MP0006292_abnormal_olfactory_placode	1.98409721
19	MP0008007_abnormal_cellular_replicative	1.87877962
20	MP0002102_abnormal_ear_morphology	1.87080960
21	MP0008260_abnormal_autophagy	1.81945250
22	MP0001730_embryonic_growth_arrest	1.78013014
23	MP0000678_abnormal_parathyroid_gland	1.69413166
24	MP0001929_abnormal_gametogenesis	1.65423324
25	MP0000049_abnormal_middle_ear	1.61575147
26	MP0002653_abnormal_ependyma_morphology	1.61327155
27	MP0003786_premature_aging	1.60318789
28	MP0005645_abnormal_hypothalamus_physiol	1.58752073
29	MP0002210_abnormal_sex_determination	1.57769674
30	MP0005451_abnormal_body_composition	1.54482909
31	MP0000350_abnormal_cell_proliferation	1.54161857
32	MP0002249_abnormal_larynx_morphology	1.52612733
33	MP0001529_abnormal_vocalization	1.52473529
34	MP0000313_abnormal_cell_death	1.38175175
35	MP0000358_abnormal_cell_content/	1.33700432
36	MP0005380_embryogenesis_phenotype	1.30201851
37	MP0001672_abnormal_embryogenesis/_devel	1.30201851
38	MP0001145_abnormal_male_reproductive	1.29600824
39	MP0008995_early_reproductive_senescence	1.28216644
40	MP0009840_abnormal_foam_cell	1.28211225
41	MP0000537_abnormal_urethra_morphology	1.28036885
42	MP0001346_abnormal_lacrimal_gland	1.27368729
43	MP0005501_abnormal_skin_physiology	1.26872297
44	MP0002080_prenatal_lethality	1.26014090
45	MP0000653_abnormal_sex_gland	1.25747120
46	MP0005076_abnormal_cell_differentiation	1.24236655
47	MP0004233_abnormal_muscle_weight	1.21225165
48	MP0006036_abnormal_mitochondrial_physio	1.20304993
49	MP0003698_abnormal_male_reproductive	1.17963033
50	MP0002396_abnormal_hematopoietic_system	1.17735635
51	MP0002085_abnormal_embryonic_tissue	1.17527794
52	MP0003315_abnormal_perineum_morphology	1.14837662
53	MP0000490_abnormal_crypts_of	1.11652365
54	MP0001697_abnormal_embryo_size	1.10743171
55	MP0003699_abnormal_female_reproductive	1.10690918
56	MP0002161_abnormal_fertility/fecundity	1.08492470
57	MP0002234_abnormal_pharynx_morphology	1.07708721
58	MP0001293_anophthalmia	1.05445238
59	MP0002098_abnormal_vibrissa_morphology	1.04365513
60	MP0000516_abnormal_urinary_system	1.03750845
61	MP0005367_renal/urinary_system_phenotyp	1.03750845
62	MP0004197_abnormal_fetal_growth/weight/	1.02754261
63	MP0003984_embryonic_growth_retardation	1.02729860
64	MP0005670_abnormal_white_adipose	1.02355258
65	MP0001849_ear_inflammation	1.01613097
66	MP0000750_abnormal_muscle_regeneration	1.01179748
67	MP0004133_heterotaxia	0.99246806
68	MP0001188_hyperpigmentation	0.96820544
69	MP0002796_impaired_skin_barrier	0.95648972
70	MP0002019_abnormal_tumor_incidence	0.94726393
71	MP0002088_abnormal_embryonic_growth/wei	0.93903011
72	MP0009672_abnormal_birth_weight	0.91538169
73	MP0002084_abnormal_developmental_patter	0.90883831
74	MP0000465_gastrointestinal_hemorrhage	0.90484693
75	MP0002822_catalepsy	0.88649726
76	MP0002160_abnormal_reproductive_system	0.87748732
77	MP0009333_abnormal_splenocyte_physiolog	0.87207128
78	MP0008057_abnormal_DNA_replication	0.86271741
79	MP0001119_abnormal_female_reproductive	0.83177542
80	MP0005384_cellular_phenotype	0.79780757
81	MP0005075_abnormal_melanosome_morpholog	0.79665172
82	MP0003186_abnormal_redox_activity	0.76550773
83	MP0002233_abnormal_nose_morphology	0.75904403
84	MP0000703_abnormal_thymus_morphology	0.75548275
85	MP0005410_abnormal_fertilization	0.74290213
86	MP0003861_abnormal_nervous_system	0.74148615
87	MP0003119_abnormal_digestive_system	0.73736585
88	MP0000015_abnormal_ear_pigmentation	0.73553913
89	MP0001270_distended_abdomen	0.73275883
90	MP0003646_muscle_fatigue	0.72197154
91	MP0002132_abnormal_respiratory_system	0.71896087
92	MP0000467_abnormal_esophagus_morphology	0.70158251
93	MP0002111_abnormal_tail_morphology	0.69769775
94	MP0003567_abnormal_fetal_cardiomyocyte	0.69009465
95	MP0001727_abnormal_embryo_implantation	0.68390286
96	MP0004808_abnormal_hematopoietic_stem	0.67705974
97	MP0002722_abnormal_immune_system	0.67654263
98	MP0003121_genomic_imprinting	0.65131180
99	MP0002254_reproductive_system_inflammat	0.62375216
100	MP0002970_abnormal_white_adipose	0.62222260

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Microvesicular hepatic steatosis (HP:0001414)	4.42173811
2	Ragged-red muscle fibers (HP:0003200)	3.80235562
3	Broad distal phalanx of finger (HP:0009836)	3.04264741
4	Premature ovarian failure (HP:0008209)	2.96783006
5	Cholecystitis (HP:0001082)	2.94681205
6	Abnormal gallbladder physiology (HP:0012438)	2.94681205
7	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.88741013
8	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.84798916
9	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.84798916
10	Peripheral hypomyelination (HP:0007182)	2.81474948
11	Male infertility (HP:0003251)	2.75744468
12	Horseshoe kidney (HP:0000085)	2.70271904
13	Septate vagina (HP:0001153)	2.69664158
14	High anterior hairline (HP:0009890)	2.65181912
15	Microretrognathia (HP:0000308)	2.62887603
16	Carpal bone hypoplasia (HP:0001498)	2.61639344
17	Cerebral hypomyelination (HP:0006808)	2.53203973
18	Impulsivity (HP:0100710)	2.53114238
19	Shoulder girdle muscle weakness (HP:0003547)	2.53078483
20	Rough bone trabeculation (HP:0100670)	2.50599532
21	Long palpebral fissure (HP:0000637)	2.41791455
22	Progressive muscle weakness (HP:0003323)	2.40452981
23	Hypergonadotropic hypogonadism (HP:0000815)	2.36784536
24	Squamous cell carcinoma (HP:0002860)	2.35444462
25	Optic nerve coloboma (HP:0000588)	2.32883618
26	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.30075239
27	Failure to thrive in infancy (HP:0001531)	2.30031214
28	Abnormal number of erythroid precursors (HP:0012131)	2.29323757
29	Urethral obstruction (HP:0000796)	2.28422076
30	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.27972480
31	Self-mutilation (HP:0000742)	2.26544606
32	Increased muscle lipid content (HP:0009058)	2.26222137
33	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.24000307
34	Abnormal protein N-linked glycosylation (HP:0012347)	2.24000307
35	Abnormal protein glycosylation (HP:0012346)	2.24000307
36	Abnormal glycosylation (HP:0012345)	2.24000307
37	Retinal dysplasia (HP:0007973)	2.23962719
38	Birth length less than 3rd percentile (HP:0003561)	2.21051524
39	Hyperglycinemia (HP:0002154)	2.20178312
40	Hyperacusis (HP:0010780)	2.18217583
41	Progressive microcephaly (HP:0000253)	2.18008505
42	Patellar aplasia (HP:0006443)	2.15668269
43	Abnormality of the columella (HP:0009929)	2.14716460
44	Proximal placement of thumb (HP:0009623)	2.13339277
45	Growth hormone excess (HP:0000845)	2.12737409
46	Hand muscle atrophy (HP:0009130)	2.11350293
47	Abnormality of the labia minora (HP:0012880)	2.10119610
48	Selective tooth agenesis (HP:0001592)	2.09486865
49	Myopathic facies (HP:0002058)	2.09263234
50	Aplasia/Hypoplasia of the patella (HP:0006498)	2.05560442
51	Short 5th finger (HP:0009237)	2.05405328
52	Increased intramyocellular lipid droplets (HP:0012240)	2.05081633
53	Severe visual impairment (HP:0001141)	2.03019838
54	Cleft eyelid (HP:0000625)	2.02843626
55	Impaired proprioception (HP:0010831)	2.02528145
56	Abnormal number of incisors (HP:0011064)	2.01105660
57	Cerebellar hypoplasia (HP:0001321)	2.00954647
58	Abnormality of cells of the erythroid lineage (HP:0012130)	1.99398951
59	Hypoplastic pelvis (HP:0008839)	1.99387799
60	Abnormality of abdominal situs (HP:0011620)	1.98174966
61	Abdominal situs inversus (HP:0003363)	1.98174966
62	Secondary amenorrhea (HP:0000869)	1.96528788
63	Absent epiphyses (HP:0010577)	1.93670194
64	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.93670194
65	Absent thumb (HP:0009777)	1.93275074
66	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	1.91010546
67	Facial hemangioma (HP:0000329)	1.90025839
68	Prominent metopic ridge (HP:0005487)	1.89801934
69	Multiple enchondromatosis (HP:0005701)	1.87000535
70	Abnormality of the distal phalanges of the toes (HP:0010182)	1.86806272
71	Entropion (HP:0000621)	1.86484180
72	Pendular nystagmus (HP:0012043)	1.85776584
73	Abnormality of the aortic arch (HP:0012303)	1.85728217
74	Thoracic kyphosis (HP:0002942)	1.85304924
75	Testicular atrophy (HP:0000029)	1.85052406
76	Hypokinesia (HP:0002375)	1.84707416
77	Upper limb muscle weakness (HP:0003484)	1.84493944
78	Poikiloderma (HP:0001029)	1.82173247
79	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.81747854
80	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.81025800
81	Abnormal mitochondria in muscle tissue (HP:0008316)	1.80324620
82	External ophthalmoplegia (HP:0000544)	1.78399592
83	Deviation of the thumb (HP:0009603)	1.77897049
84	Short thumb (HP:0009778)	1.77746683
85	Premature skin wrinkling (HP:0100678)	1.77359102
86	Abnormality of the thoracic spine (HP:0100711)	1.77354500
87	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.76592936
88	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.76176035
89	Distal upper limb amyotrophy (HP:0007149)	1.75695693
90	Upper limb amyotrophy (HP:0009129)	1.75695693
91	Abnormality of lateral ventricle (HP:0030047)	1.73324630
92	Increased serum lactate (HP:0002151)	1.72509990
93	Hepatocellular necrosis (HP:0001404)	1.71562118
94	Abnormality of the metopic suture (HP:0005556)	1.71423784
95	Facial cleft (HP:0002006)	1.71373799
96	Ureteral duplication (HP:0000073)	1.69328382
97	Abnormal trabecular bone morphology (HP:0100671)	1.68938323
98	Infertility (HP:0000789)	1.68123779
99	Degeneration of anterior horn cells (HP:0002398)	1.67954397
100	Abnormality of the anterior horn cell (HP:0006802)	1.67954397

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIM2	3.88453509
2	BCKDK	3.22228951
3	SMG1	3.02788681
4	NME2	2.95650708
5	BUB1	2.83883009
6	TESK2	2.79308653
7	VRK2	2.71284615
8	SRPK1	2.49196522
9	CDK12	2.47643223
10	MAP3K11	2.11695444
11	CDC7	2.05810860
12	AURKA	1.92281060
13	MAP2K7	1.88180957
14	ERN1	1.64556456
15	CDK7	1.64517045
16	IRAK3	1.63517903
17	TESK1	1.63299642
18	TAOK1	1.61896935
19	MAP4K1	1.46262468
20	CHEK2	1.43567443
21	RAF1	1.42400105
22	CSNK1G3	1.41753401
23	MAP2K3	1.41355033
24	PLK1	1.40844281
25	ARAF	1.37205729
26	TRIB3	1.36184599
27	TAOK2	1.36107878
28	ATR	1.34308084
29	VRK1	1.32870854
30	KDR	1.30611298
31	LMTK2	1.29670774
32	CCNB1	1.29007670
33	NME1	1.25928115
34	SIK1	1.21867127
35	PRPF4B	1.20847066
36	TRIM28	1.17464984
37	BRSK1	1.15468838
38	CSNK1A1L	1.14139776
39	TTK	1.13173962
40	DYRK3	1.12880266
41	CHEK1	1.09650030
42	CDK9	1.07815570
43	BRAF	1.06131581
44	MAP4K2	1.05727652
45	INSRR	1.03227461
46	DYRK1B	1.00285987
47	EPHA2	1.00122352
48	STK16	0.98458453
49	MAP3K6	0.98320625
50	CSNK1G1	0.97204666
51	ICK	0.96243721
52	CDK19	0.93702301
53	DAPK1	0.91276973
54	PRKCI	0.90827310
55	NEK1	0.90090622
56	AURKB	0.89849382
57	CSNK1G2	0.87854098
58	PIM1	0.86418938
59	MTOR	0.84191862
60	CDK2	0.82543976
61	DYRK2	0.79516394
62	CDK4	0.79163103
63	NEK2	0.78903895
64	ZAK	0.78706140
65	BRD4	0.77438152
66	CAMK1D	0.77290899
67	EEF2K	0.75305130
68	PLK4	0.72493810
69	MAP3K8	0.72403087
70	PRKD2	0.72002890
71	PBK	0.71601041
72	ABL2	0.68871099
73	CDK1	0.59824209
74	RPS6KA1	0.58452572
75	PAK1	0.57911311
76	ATM	0.55420387
77	PRKD3	0.54569547
78	MAP3K5	0.54456625
79	FLT3	0.54414233
80	MARK2	0.54248540
81	CLK1	0.54065189
82	AKT2	0.53318607
83	MAPK9	0.52680843
84	SIK2	0.52519838
85	IRAK2	0.50575939
86	RPS6KL1	0.49970627
87	RPS6KC1	0.49970627
88	BMX	0.47558802
89	RPS6KA5	0.46371867
90	CDK8	0.45287065
91	MAP2K4	0.45266316
92	MAP3K10	0.43844097
93	LRRK2	0.43136790
94	GRK6	0.41674243
95	TSSK6	0.40606776
96	MAPK11	0.40276367
97	RPS6KA4	0.40156251
98	CSNK2A1	0.39976633
99	HIPK2	0.38847026
100	CSF1R	0.37276571

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Base excision repair_Homo sapiens_hsa03410	4.49854515
2	DNA replication_Homo sapiens_hsa03030	4.36923048
3	Sulfur relay system_Homo sapiens_hsa04122	3.19683883
4	Mismatch repair_Homo sapiens_hsa03430	3.11302121
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.97488091
6	Spliceosome_Homo sapiens_hsa03040	2.63046472
7	RNA transport_Homo sapiens_hsa03013	2.60191161
8	Homologous recombination_Homo sapiens_hsa03440	2.36752494
9	Cell cycle_Homo sapiens_hsa04110	2.35652644
10	RNA polymerase_Homo sapiens_hsa03020	2.29152118
11	Pyrimidine metabolism_Homo sapiens_hsa00240	2.21632360
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.17179768
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.07652795
14	Non-homologous end-joining_Homo sapiens_hsa03450	2.00916079
15	mRNA surveillance pathway_Homo sapiens_hsa03015	1.92642414
16	Proteasome_Homo sapiens_hsa03050	1.88232999
17	Basal transcription factors_Homo sapiens_hsa03022	1.81487305
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.79863901
19	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.73294596
20	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.65453650
21	Pentose phosphate pathway_Homo sapiens_hsa00030	1.49475682
22	RNA degradation_Homo sapiens_hsa03018	1.44603935
23	Ribosome_Homo sapiens_hsa03010	1.41572132
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.41193855
25	Notch signaling pathway_Homo sapiens_hsa04330	1.33303864
26	p53 signaling pathway_Homo sapiens_hsa04115	1.33172781
27	Acute myeloid leukemia_Homo sapiens_hsa05221	1.28030067
28	Carbon metabolism_Homo sapiens_hsa01200	1.20029401
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.18395001
30	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.18270511
31	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.16096838
32	Folate biosynthesis_Homo sapiens_hsa00790	1.13033904
33	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.07142895
34	Bladder cancer_Homo sapiens_hsa05219	1.05973388
35	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.04069668
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.02865432
37	Oocyte meiosis_Homo sapiens_hsa04114	0.99267025
38	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.99043078
39	Purine metabolism_Homo sapiens_hsa00230	0.98051737
40	Steroid biosynthesis_Homo sapiens_hsa00100	0.96858518
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.94094875
42	One carbon pool by folate_Homo sapiens_hsa00670	0.93020169
43	Viral carcinogenesis_Homo sapiens_hsa05203	0.92160685
44	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.90614669
45	Huntingtons disease_Homo sapiens_hsa05016	0.89790527
46	Fatty acid elongation_Homo sapiens_hsa00062	0.87705622
47	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.84489980
48	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.83988908
49	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.83349166
50	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.81874614
51	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.81549215
52	Selenocompound metabolism_Homo sapiens_hsa00450	0.78594881
53	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.78492928
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.78451661
55	Herpes simplex infection_Homo sapiens_hsa05168	0.77380918
56	Alcoholism_Homo sapiens_hsa05034	0.76894435
57	Galactose metabolism_Homo sapiens_hsa00052	0.75425462
58	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.75157828
59	Parkinsons disease_Homo sapiens_hsa05012	0.74446491
60	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.67863270
61	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.66894173
62	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.65664597
63	Shigellosis_Homo sapiens_hsa05131	0.62968869
64	Apoptosis_Homo sapiens_hsa04210	0.62458577
65	Thyroid cancer_Homo sapiens_hsa05216	0.62041975
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.60139782
67	Lysine degradation_Homo sapiens_hsa00310	0.59277085
68	Hepatitis B_Homo sapiens_hsa05161	0.58694221
69	Vibrio cholerae infection_Homo sapiens_hsa05110	0.57191372
70	Regulation of autophagy_Homo sapiens_hsa04140	0.57120795
71	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.55255340
72	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.53486814
73	AMPK signaling pathway_Homo sapiens_hsa04152	0.52903937
74	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.52619408
75	Pyruvate metabolism_Homo sapiens_hsa00620	0.52254256
76	HTLV-I infection_Homo sapiens_hsa05166	0.50451510
77	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.50397634
78	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.47308782
79	Colorectal cancer_Homo sapiens_hsa05210	0.45975083
80	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.44007877
81	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.44006480
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42904741
83	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.41498602
84	Primary immunodeficiency_Homo sapiens_hsa05340	0.41441658
85	Non-small cell lung cancer_Homo sapiens_hsa05223	0.41306234
86	Metabolic pathways_Homo sapiens_hsa01100	0.41215720
87	Basal cell carcinoma_Homo sapiens_hsa05217	0.40727195
88	MicroRNAs in cancer_Homo sapiens_hsa05206	0.38695000
89	Oxidative phosphorylation_Homo sapiens_hsa00190	0.38331127
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34377251
91	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.31201309
92	Endometrial cancer_Homo sapiens_hsa05213	0.30694180
93	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.28877451
94	mTOR signaling pathway_Homo sapiens_hsa04150	0.27222206
95	Wnt signaling pathway_Homo sapiens_hsa04310	0.26823864
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.26808237
97	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.26405763
98	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.25985542
99	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.25049476
100	Insulin signaling pathway_Homo sapiens_hsa04910	0.25034806

ZNF574

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »