ZNF576

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pseudouridine synthesis (GO:0001522)5.17299831
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.16347462
3protein complex biogenesis (GO:0070271)5.13090224
4mitochondrial respiratory chain complex assembly (GO:0033108)4.95198335
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.86327032
6proteasome assembly (GO:0043248)4.66841551
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.64850441
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.53144946
9NADH dehydrogenase complex assembly (GO:0010257)4.53144946
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.53144946
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.40065894
12ATP synthesis coupled proton transport (GO:0015986)4.40065894
13termination of RNA polymerase III transcription (GO:0006386)4.38808787
14transcription elongation from RNA polymerase III promoter (GO:0006385)4.38808787
15chaperone-mediated protein transport (GO:0072321)4.13989610
16protein-cofactor linkage (GO:0018065)4.01889998
17base-excision repair, AP site formation (GO:0006285)3.97982871
18platelet dense granule organization (GO:0060155)3.97554162
19exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.96833253
20nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.93739242
21electron transport chain (GO:0022900)3.91730134
22respiratory electron transport chain (GO:0022904)3.91416637
23maturation of 5.8S rRNA (GO:0000460)3.91076219
24DNA deamination (GO:0045006)3.87238731
25water-soluble vitamin biosynthetic process (GO:0042364)3.85730424
26respiratory chain complex IV assembly (GO:0008535)3.83791738
27cytochrome complex assembly (GO:0017004)3.77007101
28rRNA modification (GO:0000154)3.64350220
29protein targeting to mitochondrion (GO:0006626)3.54828810
30protein K6-linked ubiquitination (GO:0085020)3.52296708
31cullin deneddylation (GO:0010388)3.47834252
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.46047809
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.46047809
34establishment of protein localization to mitochondrion (GO:0072655)3.41269291
35protein neddylation (GO:0045116)3.40807115
36peptidyl-histidine modification (GO:0018202)3.40677218
37mitochondrial RNA metabolic process (GO:0000959)3.36394582
38protein deneddylation (GO:0000338)3.34736965
39intracellular protein transmembrane import (GO:0044743)3.31016060
40negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.30883670
41tRNA processing (GO:0008033)3.29577965
42regulation of mitochondrial translation (GO:0070129)3.28182699
43protein localization to mitochondrion (GO:0070585)3.21633365
44transcription from mitochondrial promoter (GO:0006390)3.21227362
45DNA replication checkpoint (GO:0000076)3.20055546
46DNA double-strand break processing (GO:0000729)3.14666175
47DNA catabolic process, exonucleolytic (GO:0000738)3.13558234
48protein polyglutamylation (GO:0018095)3.12535172
49L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.11959070
50replication fork processing (GO:0031297)3.11873007
51ubiquinone biosynthetic process (GO:0006744)3.11726769
52metallo-sulfur cluster assembly (GO:0031163)3.09908962
53iron-sulfur cluster assembly (GO:0016226)3.09908962
54negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05854682
55DNA damage response, detection of DNA damage (GO:0042769)3.05476571
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99259118
57regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.93628146
58regulation of mitotic spindle checkpoint (GO:1903504)2.93628146
59cellular component biogenesis (GO:0044085)2.89513003
60rRNA methylation (GO:0031167)2.89011361
61tRNA modification (GO:0006400)2.88802055
62hydrogen ion transmembrane transport (GO:1902600)2.88399625
63tRNA metabolic process (GO:0006399)2.87816359
64response to pheromone (GO:0019236)2.87528018
65regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85721061
66rRNA processing (GO:0006364)2.84723015
67ubiquinone metabolic process (GO:0006743)2.83334820
68regulation of cellular amino acid metabolic process (GO:0006521)2.82934438
69negative regulation of DNA-templated transcription, elongation (GO:0032785)2.82265049
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.82246164
71rRNA metabolic process (GO:0016072)2.82047509
72purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80300463
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79068601
74negative regulation of ligase activity (GO:0051352)2.79068601
75ATP biosynthetic process (GO:0006754)2.76456919
76purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.76435999
77GTP biosynthetic process (GO:0006183)2.76369753
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.73752306
79proton transport (GO:0015992)2.73603919
80inner mitochondrial membrane organization (GO:0007007)2.73464146
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.68777464
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68265274
83mitochondrial transport (GO:0006839)2.68003620
84ncRNA processing (GO:0034470)2.67437056
85hydrogen transport (GO:0006818)2.66692163
86preassembly of GPI anchor in ER membrane (GO:0016254)2.66064464
87spliceosomal snRNP assembly (GO:0000387)2.65796552
88postreplication repair (GO:0006301)2.65768948
89pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.65669708
90anterograde synaptic vesicle transport (GO:0048490)2.64863141
91protein transmembrane transport (GO:0071806)2.64042511
92positive regulation of ligase activity (GO:0051351)2.63528157
93signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.63498007
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.63498007
95signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.63498007
96behavioral response to nicotine (GO:0035095)2.62353698
97ncRNA metabolic process (GO:0034660)2.61853172
98intracellular protein transmembrane transport (GO:0065002)2.61304076
99transcription from RNA polymerase III promoter (GO:0006383)2.60898076
1007-methylguanosine mRNA capping (GO:0006370)2.60781141

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.19134097
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.01569549
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.60597502
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.31464748
5* EST1_17652178_ChIP-ChIP_JURKAT_Human4.27593304
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.11182126
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.76961122
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.55953569
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88293679
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.72362063
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71369625
12ZNF274_21170338_ChIP-Seq_K562_Hela2.69742963
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.67558645
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.64008768
15* VDR_23849224_ChIP-Seq_CD4+_Human2.63473267
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.58989826
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.53394192
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.46473218
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.40616230
20* FOXP3_21729870_ChIP-Seq_TREG_Human2.37966662
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29638611
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23028632
23ELK1_19687146_ChIP-ChIP_HELA_Human2.08428509
24DCP1A_22483619_ChIP-Seq_HELA_Human2.05789893
25GABP_19822575_ChIP-Seq_HepG2_Human2.00662344
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.95546172
27TTF2_22483619_ChIP-Seq_HELA_Human1.92605077
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90382056
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90101812
30MYC_18940864_ChIP-ChIP_HL60_Human1.88361856
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79272193
32XRN2_22483619_ChIP-Seq_HELA_Human1.79108244
33E2F7_22180533_ChIP-Seq_HELA_Human1.70889899
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69869064
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.68770614
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65217133
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63797706
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54577447
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52708586
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52134592
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.43189235
42IRF1_19129219_ChIP-ChIP_H3396_Human1.38771959
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35975598
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35234134
45KDM5A_27292631_Chip-Seq_BREAST_Human1.34478993
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33322625
47TP53_22573176_ChIP-Seq_HFKS_Human1.27290595
48EWS_26573619_Chip-Seq_HEK293_Human1.25252217
49VDR_22108803_ChIP-Seq_LS180_Human1.24562059
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23457345
51* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22618130
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21916592
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18536431
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17781618
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17017683
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16471692
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.14940354
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14344287
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13361678
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10869357
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10496980
62IGF1R_20145208_ChIP-Seq_DFB_Human1.06464465
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05947715
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.05780001
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04550846
66SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01431591
67CIITA_25753668_ChIP-Seq_RAJI_Human1.01389358
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01264387
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98347216
70FUS_26573619_Chip-Seq_HEK293_Human0.95019990
71FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92746051
72FOXA1_25329375_ChIP-Seq_VCAP_Human0.92746051
73AR_20517297_ChIP-Seq_VCAP_Human0.92710948
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88829553
75ERA_21632823_ChIP-Seq_H3396_Human0.88399987
76NCOR_22424771_ChIP-Seq_293T_Human0.88365341
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88095079
78CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87531604
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86597068
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86592478
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86556024
82CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85424599
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85188945
84MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84980758
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84043131
86* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83763720
87POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82230647
88MYC_19829295_ChIP-Seq_ESCs_Human0.82102022
89* FOXP1_21924763_ChIP-Seq_HESCs_Human0.81874980
90CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80908635
91BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79561617
92PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78762911
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77643817
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.77394168
95TAF2_19829295_ChIP-Seq_ESCs_Human0.76509692
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.76439650
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.76159398
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.75600535
99CTBP1_25329375_ChIP-Seq_LNCAP_Human0.74116894
100SOX2_16153702_ChIP-ChIP_HESCs_Human0.72985208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.17571437
2MP0003693_abnormal_embryo_hatching2.88158670
3MP0002837_dystrophic_cardiac_calcinosis2.84651714
4MP0002163_abnormal_gland_morphology2.80480979
5MP0008877_abnormal_DNA_methylation2.55975822
6MP0006036_abnormal_mitochondrial_physio2.50221517
7MP0006072_abnormal_retinal_apoptosis2.37631294
8MP0005075_abnormal_melanosome_morpholog2.29794322
9MP0003786_premature_aging2.29600412
10MP0003718_maternal_effect2.29186981
11MP0003806_abnormal_nucleotide_metabolis2.21945494
12MP0005551_abnormal_eye_electrophysiolog2.02886984
13MP0005379_endocrine/exocrine_gland_phen2.00845553
14MP0010094_abnormal_chromosome_stability1.98204973
15MP0004142_abnormal_muscle_tone1.95108772
16MP0002102_abnormal_ear_morphology1.93757013
17MP0008875_abnormal_xenobiotic_pharmacok1.91088839
18MP0006035_abnormal_mitochondrial_morpho1.89117815
19MP0003646_muscle_fatigue1.87171671
20MP0001968_abnormal_touch/_nociception1.85039367
21MP0002736_abnormal_nociception_after1.81289513
22MP0008872_abnormal_physiological_respon1.74384732
23MP0003186_abnormal_redox_activity1.73437004
24MP0001529_abnormal_vocalization1.70385819
25MP0009046_muscle_twitch1.68959082
26MP0004885_abnormal_endolymph1.68139644
27MP0002638_abnormal_pupillary_reflex1.67894031
28MP0002938_white_spotting1.67639264
29MP0005253_abnormal_eye_physiology1.65494006
30MP0003011_delayed_dark_adaptation1.65297995
31MP0005645_abnormal_hypothalamus_physiol1.63044142
32MP0003195_calcinosis1.59088474
33MP0004147_increased_porphyrin_level1.57747090
34MP0001905_abnormal_dopamine_level1.56638508
35MP0008789_abnormal_olfactory_epithelium1.51223502
36MP0005423_abnormal_somatic_nervous1.48028475
37MP0003111_abnormal_nucleus_morphology1.46376107
38MP0000372_irregular_coat_pigmentation1.44693351
39MP0002160_abnormal_reproductive_system1.44299566
40MP0001764_abnormal_homeostasis1.43237387
41MP0008995_early_reproductive_senescence1.42802260
42MP0001986_abnormal_taste_sensitivity1.41732421
43MP0002272_abnormal_nervous_system1.38589766
44MP0001346_abnormal_lacrimal_gland1.35202220
45MP0005084_abnormal_gallbladder_morpholo1.35174623
46MP0004957_abnormal_blastocyst_morpholog1.34737258
47MP0004133_heterotaxia1.33375854
48MP0009745_abnormal_behavioral_response1.31654874
49MP0005389_reproductive_system_phenotype1.29305655
50MP0005332_abnormal_amino_acid1.28187775
51MP0001727_abnormal_embryo_implantation1.25455117
52MP0005646_abnormal_pituitary_gland1.20433585
53MP0001919_abnormal_reproductive_system1.20266504
54MP0000015_abnormal_ear_pigmentation1.17750215
55MP0002210_abnormal_sex_determination1.17152319
56MP0008932_abnormal_embryonic_tissue1.15673668
57MP0000516_abnormal_urinary_system1.15404671
58MP0005367_renal/urinary_system_phenotyp1.15404671
59MP0001929_abnormal_gametogenesis1.14954313
60MP0005174_abnormal_tail_pigmentation1.13992900
61MP0000631_abnormal_neuroendocrine_gland1.11009982
62MP0002095_abnormal_skin_pigmentation1.08080614
63MP0000358_abnormal_cell_content/1.05986949
64MP0002876_abnormal_thyroid_physiology1.05885374
65MP0000653_abnormal_sex_gland1.05432092
66MP0006292_abnormal_olfactory_placode1.03682999
67MP0002653_abnormal_ependyma_morphology1.03511854
68MP0001145_abnormal_male_reproductive1.03459227
69MP0001984_abnormal_olfaction1.02819520
70MP0003880_abnormal_central_pattern1.02697256
71MP0002277_abnormal_respiratory_mucosa1.00771902
72MP0003077_abnormal_cell_cycle0.98882798
73MP0003698_abnormal_male_reproductive0.98212012
74MP0003787_abnormal_imprinting0.98159828
75MP0004043_abnormal_pH_regulation0.97038631
76MP0001188_hyperpigmentation0.95147928
77MP0008007_abnormal_cellular_replicative0.94292736
78MP0002751_abnormal_autonomic_nervous0.93880854
79MP0003137_abnormal_impulse_conducting0.91072657
80MP0006276_abnormal_autonomic_nervous0.90185434
81MP0003136_yellow_coat_color0.88832044
82MP0005410_abnormal_fertilization0.88380213
83MP0004145_abnormal_muscle_electrophysio0.88094579
84MP0002572_abnormal_emotion/affect_behav0.85078499
85MP0005394_taste/olfaction_phenotype0.83099356
86MP0005499_abnormal_olfactory_system0.83099356
87MP0005195_abnormal_posterior_eye0.81996064
88MP0003121_genomic_imprinting0.81920155
89MP0002557_abnormal_social/conspecific_i0.79116299
90MP0002229_neurodegeneration0.78969229
91MP0002064_seizures0.78109000
92MP0002752_abnormal_somatic_nervous0.76749996
93MP0005395_other_phenotype0.74905471
94MP0001501_abnormal_sleep_pattern0.72045145
95MP0001963_abnormal_hearing_physiology0.70643891
96MP0000026_abnormal_inner_ear0.69758069
97MP0000538_abnormal_urinary_bladder0.69380696
98MP0010386_abnormal_urinary_bladder0.67269689
99MP0003567_abnormal_fetal_cardiomyocyte0.66608563
100MP0002735_abnormal_chemical_nociception0.65800357

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.75401011
2Abnormal mitochondria in muscle tissue (HP:0008316)4.58443174
3Mitochondrial inheritance (HP:0001427)4.31284393
4Increased CSF lactate (HP:0002490)4.16746603
5Acute encephalopathy (HP:0006846)4.05841133
6Progressive macrocephaly (HP:0004481)4.05329085
7Hepatocellular necrosis (HP:0001404)3.66848594
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.58678850
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.58678850
10Lipid accumulation in hepatocytes (HP:0006561)3.53143278
11Increased hepatocellular lipid droplets (HP:0006565)3.50282328
12Abnormality of midbrain morphology (HP:0002418)3.45339976
13Molar tooth sign on MRI (HP:0002419)3.45339976
14Hepatic necrosis (HP:0002605)3.41007828
15Pancreatic cysts (HP:0001737)3.24673790
16Congenital stationary night blindness (HP:0007642)3.16142024
17Increased serum lactate (HP:0002151)3.12187629
18Renal Fanconi syndrome (HP:0001994)3.11790214
19Pancreatic fibrosis (HP:0100732)3.04794835
20Abnormal number of erythroid precursors (HP:0012131)2.95508347
213-Methylglutaconic aciduria (HP:0003535)2.94753441
22Increased intramyocellular lipid droplets (HP:0012240)2.91906916
23Nephronophthisis (HP:0000090)2.88676051
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.88264981
25Lactic acidosis (HP:0003128)2.87196847
26True hermaphroditism (HP:0010459)2.86943831
27Cerebral edema (HP:0002181)2.86618745
28Medial flaring of the eyebrow (HP:0010747)2.79131549
29Methylmalonic aciduria (HP:0012120)2.67592323
30Optic disc pallor (HP:0000543)2.57427976
31Absent thumb (HP:0009777)2.56057829
32Increased muscle lipid content (HP:0009058)2.55412526
33Methylmalonic acidemia (HP:0002912)2.50824895
34Abnormality of cells of the erythroid lineage (HP:0012130)2.49718005
35Reticulocytopenia (HP:0001896)2.49034871
36Respiratory failure (HP:0002878)2.47017216
37Abnormal biliary tract physiology (HP:0012439)2.39713418
38Bile duct proliferation (HP:0001408)2.39713418
39Exercise intolerance (HP:0003546)2.38992804
40Pendular nystagmus (HP:0012043)2.31307344
41Sclerocornea (HP:0000647)2.29598180
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.26684522
43Progressive inability to walk (HP:0002505)2.20488388
44Gait imbalance (HP:0002141)2.20083803
45Abnormality of the labia minora (HP:0012880)2.17827241
46Abnormality of the renal medulla (HP:0100957)2.16676370
47Abnormality of DNA repair (HP:0003254)2.13640911
48Exertional dyspnea (HP:0002875)2.13198294
49Congenital primary aphakia (HP:0007707)2.10684197
50Lethargy (HP:0001254)2.10289409
51Aplasia/hypoplasia of the uterus (HP:0008684)2.06108178
52Chronic hepatic failure (HP:0100626)2.05858872
53Hypoplasia of the pons (HP:0012110)2.05627855
54Abnormality of alanine metabolism (HP:0010916)2.04529681
55Hyperalaninemia (HP:0003348)2.04529681
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04529681
57Nephrogenic diabetes insipidus (HP:0009806)2.02616582
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.01555668
59Attenuation of retinal blood vessels (HP:0007843)2.01347282
60Abnormality of the renal cortex (HP:0011035)1.98074090
61Type I transferrin isoform profile (HP:0003642)1.97727803
62Abnormality of urine glucose concentration (HP:0011016)1.96648531
63Glycosuria (HP:0003076)1.96648531
64Hyperglycinemia (HP:0002154)1.92922915
65Abnormal protein glycosylation (HP:0012346)1.92721794
66Abnormal glycosylation (HP:0012345)1.92721794
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92721794
68Abnormal protein N-linked glycosylation (HP:0012347)1.92721794
69Abnormality of renal resorption (HP:0011038)1.92259185
70Meckel diverticulum (HP:0002245)1.92227466
71Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90417788
72Progressive microcephaly (HP:0000253)1.90173030
73Abnormality of the pons (HP:0007361)1.88994321
74Anencephaly (HP:0002323)1.88316154
75Abnormality of the ileum (HP:0001549)1.88087656
76Leukodystrophy (HP:0002415)1.87568518
77Renal cortical cysts (HP:0000803)1.82981527
78Abnormal rod and cone electroretinograms (HP:0008323)1.82732497
79Tongue fasciculations (HP:0001308)1.82645510
80Retinal dysplasia (HP:0007973)1.81468236
81Hemiparesis (HP:0001269)1.79883548
82Type II lissencephaly (HP:0007260)1.79806794
83CNS demyelination (HP:0007305)1.79115190
84Colon cancer (HP:0003003)1.77908993
85Cutaneous melanoma (HP:0012056)1.77543949
86Male pseudohermaphroditism (HP:0000037)1.76816141
87Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76167190
88Dicarboxylic aciduria (HP:0003215)1.76167190
89Chromsome breakage (HP:0040012)1.75918177
90Horseshoe kidney (HP:0000085)1.75629766
91Inability to walk (HP:0002540)1.73535548
92Polyphagia (HP:0002591)1.73473956
93Pancytopenia (HP:0001876)1.69676614
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69298380
95Generalized aminoaciduria (HP:0002909)1.66394297
96Tubular atrophy (HP:0000092)1.66233191
97Patellar aplasia (HP:0006443)1.66160560
98Abolished electroretinogram (ERG) (HP:0000550)1.64864013
99Aplasia/Hypoplasia involving the musculature (HP:0001460)1.63150629
100Limb dystonia (HP:0002451)1.62699819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.74836117
2ZAK2.91467399
3BUB12.80135584
4FRK2.75211810
5STK162.72787924
6NUAK12.68911567
7TLK12.66308584
8ADRBK22.44776987
9MUSK2.40377572
10GRK12.38398208
11NME12.29829076
12MAP4K22.25009957
13ACVR1B2.15493633
14VRK12.14269143
15PINK12.12444778
16BMPR1B2.02737398
17TESK21.79605562
18WNK31.77969732
19SRPK11.71385233
20NME21.55838773
21BCKDK1.54244857
22CDC71.53552032
23CDK81.47134266
24MST41.46276795
25PLK41.46145287
26PLK31.41589780
27PBK1.39420319
28DYRK21.38609349
29EIF2AK31.32345673
30MAP3K41.32275090
31EIF2AK11.29544587
32CSNK1G21.27770602
33PLK11.19450928
34CSNK1G31.16096621
35PHKG21.12341186
36PHKG11.12341186
37LIMK11.08044093
38CCNB11.07373252
39ERBB31.03905527
40PDK21.02784997
41TAF11.01673861
42TSSK60.99192528
43WNK40.98966886
44ATR0.97181543
45ABL20.95790808
46PIM20.94896636
47CHEK20.94727510
48CSNK1G10.94243918
49MAPK130.90332860
50MAP2K70.89869934
51ADRBK10.86925641
52AURKA0.86235902
53PRKCG0.84780251
54TRIM280.83048583
55CSNK1A1L0.81838654
56TXK0.80235856
57OXSR10.79380105
58RPS6KA50.76702879
59MAPKAPK30.74950406
60DAPK10.74891860
61TIE10.74440650
62TAOK30.73904512
63PRKCI0.69349483
64MKNK20.68831787
65IKBKB0.68642490
66MAPK150.66486133
67INSRR0.58654273
68TTK0.58290611
69PKN10.58020910
70PASK0.57003522
71STK390.56147115
72DAPK20.55102937
73AURKB0.53080797
74GRK70.52990919
75TGFBR10.50385947
76GRK50.49456151
77CSNK2A10.49438352
78PAK30.47765792
79KDR0.47754699
80EIF2AK20.46724857
81PRKCE0.46501261
82WEE10.45370294
83PNCK0.43842614
84NEK10.43733315
85CSNK1A10.43210642
86MAP2K20.40803872
87CDK190.40402460
88CSNK2A20.39972481
89PLK20.39966012
90ATM0.39364931
91MAPKAPK50.39357730
92DAPK30.37701741
93MAP2K60.36005215
94ILK0.35718498
95MAP3K120.35221234
96TEC0.35061255
97PRKACA0.33590387
98PRKCQ0.31960625
99PRKCA0.30840755
100CHEK10.30748745

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.95168874
2Proteasome_Homo sapiens_hsa030503.48829096
3RNA polymerase_Homo sapiens_hsa030203.37764922
4Parkinsons disease_Homo sapiens_hsa050123.22783105
5Ribosome_Homo sapiens_hsa030102.77168110
6Protein export_Homo sapiens_hsa030602.61903115
7Homologous recombination_Homo sapiens_hsa034402.55402520
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.37836010
9DNA replication_Homo sapiens_hsa030302.29905686
10Huntingtons disease_Homo sapiens_hsa050162.21772976
11Mismatch repair_Homo sapiens_hsa034302.06372282
12Alzheimers disease_Homo sapiens_hsa050102.05553559
13Sulfur relay system_Homo sapiens_hsa041222.00874360
14Fanconi anemia pathway_Homo sapiens_hsa034601.94410215
15Base excision repair_Homo sapiens_hsa034101.92030724
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85199745
17Nucleotide excision repair_Homo sapiens_hsa034201.84940958
18RNA degradation_Homo sapiens_hsa030181.81899915
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76850247
20Pyrimidine metabolism_Homo sapiens_hsa002401.76531587
21Collecting duct acid secretion_Homo sapiens_hsa049661.75423098
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69884564
23Basal transcription factors_Homo sapiens_hsa030221.69170883
24Cardiac muscle contraction_Homo sapiens_hsa042601.48967872
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48208229
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46999656
27Folate biosynthesis_Homo sapiens_hsa007901.46466801
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46072481
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38398058
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37785215
31One carbon pool by folate_Homo sapiens_hsa006701.37404475
32Sulfur metabolism_Homo sapiens_hsa009201.33153982
33Phototransduction_Homo sapiens_hsa047441.29932948
34Purine metabolism_Homo sapiens_hsa002301.28345915
35Non-homologous end-joining_Homo sapiens_hsa034501.27602506
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26358572
37Fatty acid elongation_Homo sapiens_hsa000621.25914486
38Spliceosome_Homo sapiens_hsa030401.23346654
39Butanoate metabolism_Homo sapiens_hsa006501.17974912
40Nitrogen metabolism_Homo sapiens_hsa009101.15458616
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15180381
42RNA transport_Homo sapiens_hsa030131.14397932
43Peroxisome_Homo sapiens_hsa041461.13263094
44Selenocompound metabolism_Homo sapiens_hsa004501.13103498
45Propanoate metabolism_Homo sapiens_hsa006401.10035001
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09734409
47Pyruvate metabolism_Homo sapiens_hsa006201.04683704
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01435973
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.97996709
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93686996
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88057855
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.87791194
53Metabolic pathways_Homo sapiens_hsa011000.87262185
54Steroid biosynthesis_Homo sapiens_hsa001000.84772838
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82052412
56Linoleic acid metabolism_Homo sapiens_hsa005910.77988287
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74528370
58Tryptophan metabolism_Homo sapiens_hsa003800.73672581
59Regulation of autophagy_Homo sapiens_hsa041400.73331388
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73290794
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.72844400
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68998981
63Nicotine addiction_Homo sapiens_hsa050330.66800250
64Arginine and proline metabolism_Homo sapiens_hsa003300.63444213
65Vitamin B6 metabolism_Homo sapiens_hsa007500.62078777
66Fatty acid metabolism_Homo sapiens_hsa012120.59640631
67beta-Alanine metabolism_Homo sapiens_hsa004100.58607417
68Glutathione metabolism_Homo sapiens_hsa004800.56782291
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56605652
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53845178
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.52942302
72Synaptic vesicle cycle_Homo sapiens_hsa047210.52859251
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.50621630
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.49903807
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47639184
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45896486
77Taste transduction_Homo sapiens_hsa047420.44526041
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43220560
79Arachidonic acid metabolism_Homo sapiens_hsa005900.43135867
80Ether lipid metabolism_Homo sapiens_hsa005650.42353534
81Caffeine metabolism_Homo sapiens_hsa002320.41912867
82Cell cycle_Homo sapiens_hsa041100.40449297
83Primary immunodeficiency_Homo sapiens_hsa053400.39852986
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39529000
85Chemical carcinogenesis_Homo sapiens_hsa052040.36254310
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36027257
87Vitamin digestion and absorption_Homo sapiens_hsa049770.35899502
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35839129
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34612688
90Fatty acid degradation_Homo sapiens_hsa000710.32966554
91N-Glycan biosynthesis_Homo sapiens_hsa005100.32912542
92Oocyte meiosis_Homo sapiens_hsa041140.30661014
93Vibrio cholerae infection_Homo sapiens_hsa051100.28400293
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28140052
95Rheumatoid arthritis_Homo sapiens_hsa053230.27482121
96Retinol metabolism_Homo sapiens_hsa008300.26757530
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26048497
98Olfactory transduction_Homo sapiens_hsa047400.24798533
99Morphine addiction_Homo sapiens_hsa050320.24556755
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.24002407

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