ZNF577

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.69502000
2protein polyglutamylation (GO:0018095)4.36418697
3DNA double-strand break processing (GO:0000729)4.27688230
4neural tube formation (GO:0001841)4.16384498
5regulation of meiosis I (GO:0060631)3.94237468
6negative regulation of translation, ncRNA-mediated (GO:0040033)3.79078309
7regulation of translation, ncRNA-mediated (GO:0045974)3.79078309
8negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.79078309
9establishment of protein localization to Golgi (GO:0072600)3.66813086
10regulation of cilium movement (GO:0003352)3.61973683
11epithelial cilium movement (GO:0003351)3.58709753
12limb bud formation (GO:0060174)3.50094145
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.48977051
14somite development (GO:0061053)3.47591561
15pyrimidine nucleobase catabolic process (GO:0006208)3.37484771
16detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.33681527
17protein targeting to Golgi (GO:0000042)3.32806062
18regulation of glucokinase activity (GO:0033131)3.30902228
19regulation of hexokinase activity (GO:1903299)3.30902228
20histone mRNA catabolic process (GO:0071044)3.12520639
21retrograde transport, vesicle recycling within Golgi (GO:0000301)3.12253354
22prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.12214248
23presynaptic membrane assembly (GO:0097105)3.10245541
24intraciliary transport (GO:0042073)3.08641839
25regulation of collateral sprouting (GO:0048670)3.08501683
26nonmotile primary cilium assembly (GO:0035058)3.08126146
27DNA integration (GO:0015074)3.07403733
28acrosome reaction (GO:0007340)3.07061907
29protein localization to cilium (GO:0061512)3.01885485
30protein K11-linked deubiquitination (GO:0035871)2.99883167
31cilium morphogenesis (GO:0060271)2.97802285
32sperm motility (GO:0030317)2.96555662
33DNA demethylation (GO:0080111)2.94243358
34estrogen biosynthetic process (GO:0006703)2.91965785
35indolalkylamine metabolic process (GO:0006586)2.90293503
36otic vesicle formation (GO:0030916)2.89993078
37platelet dense granule organization (GO:0060155)2.87641943
38protein localization to Golgi apparatus (GO:0034067)2.84410322
39centriole replication (GO:0007099)2.84366341
40negative regulation of DNA-dependent DNA replication (GO:2000104)2.84246824
41photoreceptor cell maintenance (GO:0045494)2.83576483
42cilium organization (GO:0044782)2.83502231
43regulation of telomere maintenance (GO:0032204)2.81874941
44regulation of action potential (GO:0098900)2.80085284
45piRNA metabolic process (GO:0034587)2.79799814
46cilium assembly (GO:0042384)2.78584930
47cilium movement (GO:0003341)2.78284850
48seminiferous tubule development (GO:0072520)2.76725015
49indole-containing compound catabolic process (GO:0042436)2.76094117
50indolalkylamine catabolic process (GO:0046218)2.76094117
51tryptophan catabolic process (GO:0006569)2.76094117
52tryptophan metabolic process (GO:0006568)2.69069640
53gamma-aminobutyric acid transport (GO:0015812)2.68505403
54single strand break repair (GO:0000012)2.67764380
55respiratory chain complex IV assembly (GO:0008535)2.67140352
56cell wall macromolecule metabolic process (GO:0044036)2.66223357
57cerebral cortex radially oriented cell migration (GO:0021799)2.66090072
58protein complex biogenesis (GO:0070271)2.64855882
59histone mRNA metabolic process (GO:0008334)2.64584542
60adaptation of signaling pathway (GO:0023058)2.64448531
61recombinational repair (GO:0000725)2.63596639
62prenylation (GO:0097354)2.60320336
63protein prenylation (GO:0018342)2.60320336
64regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.59787706
65replication fork processing (GO:0031297)2.59480261
66neuron cell-cell adhesion (GO:0007158)2.58922213
67negative regulation of telomere maintenance (GO:0032205)2.57840611
68double-strand break repair via homologous recombination (GO:0000724)2.57684548
69axoneme assembly (GO:0035082)2.57111938
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.57015231
71adenosine metabolic process (GO:0046085)2.55482277
72Golgi to endosome transport (GO:0006895)2.55252151
73mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54288079
74mitochondrial respiratory chain complex I assembly (GO:0032981)2.54288079
75NADH dehydrogenase complex assembly (GO:0010257)2.54288079
76histone H2A acetylation (GO:0043968)2.53516862
77presynaptic membrane organization (GO:0097090)2.53483138
78protein-cofactor linkage (GO:0018065)2.52413823
79mitochondrial respiratory chain complex assembly (GO:0033108)2.52401152
80detection of light stimulus involved in visual perception (GO:0050908)2.52142086
81detection of light stimulus involved in sensory perception (GO:0050962)2.52142086
82cellular ketone body metabolic process (GO:0046950)2.51395195
83regulation of nuclear cell cycle DNA replication (GO:0033262)2.51326229
84behavioral response to nicotine (GO:0035095)2.51119444
85ubiquinone metabolic process (GO:0006743)2.50906287
86response to misfolded protein (GO:0051788)2.49580598
87negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48866499
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.48580843
89cell wall macromolecule catabolic process (GO:0016998)2.48362194
90L-fucose catabolic process (GO:0042355)2.48159644
91fucose catabolic process (GO:0019317)2.48159644
92L-fucose metabolic process (GO:0042354)2.48159644
93water-soluble vitamin biosynthetic process (GO:0042364)2.47507709
94cytochrome complex assembly (GO:0017004)2.47110699
95C4-dicarboxylate transport (GO:0015740)2.46939970
96nucleobase catabolic process (GO:0046113)2.46016558
97retinal cone cell development (GO:0046549)2.45732881
98regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.45580713
99regulation of mitotic spindle checkpoint (GO:1903504)2.45580713
100postsynaptic membrane organization (GO:0001941)2.44471168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.68664435
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.27825781
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.26060080
4IGF1R_20145208_ChIP-Seq_DFB_Human2.98449824
5VDR_22108803_ChIP-Seq_LS180_Human2.95508680
6GBX2_23144817_ChIP-Seq_PC3_Human2.85137107
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.72553961
8FUS_26573619_Chip-Seq_HEK293_Human2.53641626
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.46303714
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35376082
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34065077
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.30211467
13P300_19829295_ChIP-Seq_ESCs_Human2.22582068
14PIAS1_25552417_ChIP-Seq_VCAP_Human2.22119802
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20246637
16EWS_26573619_Chip-Seq_HEK293_Human2.13019335
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11336119
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.11021912
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05309188
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.05017832
21TAF15_26573619_Chip-Seq_HEK293_Human2.02870557
22EZH2_22144423_ChIP-Seq_EOC_Human1.94794870
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81888490
24* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79200736
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78568024
26SMAD4_21799915_ChIP-Seq_A2780_Human1.76089404
27ER_23166858_ChIP-Seq_MCF-7_Human1.72642848
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69744929
29CBP_20019798_ChIP-Seq_JUKART_Human1.69744929
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64051390
31* AR_25329375_ChIP-Seq_VCAP_Human1.61958604
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61538426
33IRF1_19129219_ChIP-ChIP_H3396_Human1.61115407
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59881409
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59881409
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.53931193
37STAT3_23295773_ChIP-Seq_U87_Human1.53670348
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53606439
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53317204
40* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52046163
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51442796
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50518472
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48796741
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48643828
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47701250
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46152036
47ELK1_19687146_ChIP-ChIP_HELA_Human1.45539286
48* SMAD3_21741376_ChIP-Seq_EPCs_Human1.45419340
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.45235295
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44468510
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.43826364
52TCF4_23295773_ChIP-Seq_U87_Human1.42071404
53TP53_22573176_ChIP-Seq_HFKS_Human1.40005066
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37321186
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36941379
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.36937517
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35489956
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.33498071
59RUNX2_22187159_ChIP-Seq_PCA_Human1.33068832
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29073954
61BCAT_22108803_ChIP-Seq_LS180_Human1.27569763
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26358795
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.25910007
64SOX2_19829295_ChIP-Seq_ESCs_Human1.24487882
65NANOG_19829295_ChIP-Seq_ESCs_Human1.24487882
66* TCF4_22108803_ChIP-Seq_LS180_Human1.21724969
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21475561
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20348028
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20052118
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.18032220
71AR_21572438_ChIP-Seq_LNCaP_Human1.16453718
72VDR_23849224_ChIP-Seq_CD4+_Human1.15860074
73* SMAD4_21741376_ChIP-Seq_EPCs_Human1.14444571
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13373707
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12920966
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11716572
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.09205809
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.09133180
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.09120808
80P53_22387025_ChIP-Seq_ESCs_Mouse1.06567810
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06435391
82MYC_18940864_ChIP-ChIP_HL60_Human1.04402318
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.03088615
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.00731700
85TAL1_26923725_Chip-Seq_HPCs_Mouse0.98970406
86PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98607145
87ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97677018
88OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97487692
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97350240
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97129665
91* CDX2_22108803_ChIP-Seq_LS180_Human0.95375297
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95279966
93FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94599352
94FOXA1_25329375_ChIP-Seq_VCAP_Human0.94599352
95RNF2_27304074_Chip-Seq_NSC_Mouse0.94182899
96SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93198310
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93164335
98SOX2_21211035_ChIP-Seq_LN229_Gbm0.93100590
99P300_18555785_Chip-Seq_ESCs_Mouse0.92824846
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.91532269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode2.78577142
2MP0003880_abnormal_central_pattern2.76351657
3MP0001986_abnormal_taste_sensitivity2.51749552
4MP0000569_abnormal_digit_pigmentation2.38834051
5MP0008877_abnormal_DNA_methylation2.35817160
6MP0001984_abnormal_olfaction2.21532705
7MP0005551_abnormal_eye_electrophysiolog2.15257827
8MP0002736_abnormal_nociception_after2.09524407
9MP0000383_abnormal_hair_follicle2.03168317
10MP0008058_abnormal_DNA_repair1.98590349
11MP0000516_abnormal_urinary_system1.98036692
12MP0005367_renal/urinary_system_phenotyp1.98036692
13MP0002234_abnormal_pharynx_morphology1.91871862
14MP0005410_abnormal_fertilization1.90534704
15MP0002102_abnormal_ear_morphology1.86300426
16MP0003136_yellow_coat_color1.85631842
17MP0001968_abnormal_touch/_nociception1.84977250
18MP0001485_abnormal_pinna_reflex1.82327637
19MP0003011_delayed_dark_adaptation1.80205106
20MP0006276_abnormal_autonomic_nervous1.79268557
21MP0005253_abnormal_eye_physiology1.77783531
22MP0008057_abnormal_DNA_replication1.71537480
23MP0000427_abnormal_hair_cycle1.71534444
24MP0002254_reproductive_system_inflammat1.70685410
25MP0003718_maternal_effect1.70007655
26MP0001529_abnormal_vocalization1.69795719
27MP0002653_abnormal_ependyma_morphology1.67049306
28MP0001486_abnormal_startle_reflex1.64107552
29MP0000778_abnormal_nervous_system1.58687814
30MP0002638_abnormal_pupillary_reflex1.58201229
31MP0005646_abnormal_pituitary_gland1.56010935
32MP0000631_abnormal_neuroendocrine_gland1.55003935
33MP0001293_anophthalmia1.44704430
34MP0003890_abnormal_embryonic-extraembry1.43935686
35MP0003121_genomic_imprinting1.42003318
36MP0000647_abnormal_sebaceous_gland1.41961671
37MP0008789_abnormal_olfactory_epithelium1.40985699
38MP0004742_abnormal_vestibular_system1.39896720
39MP0008995_early_reproductive_senescence1.38252701
40MP0006072_abnormal_retinal_apoptosis1.36499502
41MP0003698_abnormal_male_reproductive1.35604658
42MP0005645_abnormal_hypothalamus_physiol1.32110270
43MP0000537_abnormal_urethra_morphology1.30641735
44MP0002751_abnormal_autonomic_nervous1.28898956
45MP0004145_abnormal_muscle_electrophysio1.28885032
46MP0002938_white_spotting1.25242331
47MP0003787_abnormal_imprinting1.24770872
48MP0004043_abnormal_pH_regulation1.24426620
49MP0008872_abnormal_physiological_respon1.20479059
50MP0002272_abnormal_nervous_system1.16355333
51MP0001188_hyperpigmentation1.15720084
52MP0001929_abnormal_gametogenesis1.15460129
53MP0005423_abnormal_somatic_nervous1.14806000
54MP0005084_abnormal_gallbladder_morpholo1.13993062
55MP0004142_abnormal_muscle_tone1.11938069
56MP0002735_abnormal_chemical_nociception1.11725961
57MP0001501_abnormal_sleep_pattern1.10404635
58MP0010678_abnormal_skin_adnexa1.09499770
59MP0003122_maternal_imprinting1.06926328
60MP0003195_calcinosis1.06594419
61MP0003937_abnormal_limbs/digits/tail_de1.01771831
62MP0004215_abnormal_myocardial_fiber0.99654293
63MP0002282_abnormal_trachea_morphology0.99257300
64MP0005394_taste/olfaction_phenotype0.98469580
65MP0005499_abnormal_olfactory_system0.98469580
66MP0001177_atelectasis0.98183299
67MP0003878_abnormal_ear_physiology0.97824169
68MP0005377_hearing/vestibular/ear_phenot0.97824169
69MP0002067_abnormal_sensory_capabilities0.97526377
70MP0005391_vision/eye_phenotype0.96986894
71MP0003646_muscle_fatigue0.96219727
72MP0004133_heterotaxia0.95181969
73MP0004885_abnormal_endolymph0.94392000
74MP0002210_abnormal_sex_determination0.93797668
75MP0002557_abnormal_social/conspecific_i0.92364467
76MP0002233_abnormal_nose_morphology0.92363707
77MP0001145_abnormal_male_reproductive0.92203315
78MP0000049_abnormal_middle_ear0.91284139
79MP0001764_abnormal_homeostasis0.90894556
80MP0005174_abnormal_tail_pigmentation0.90530692
81MP0003567_abnormal_fetal_cardiomyocyte0.90350022
82MP0000653_abnormal_sex_gland0.89759285
83MP0000372_irregular_coat_pigmentation0.89591338
84MP0009046_muscle_twitch0.89048982
85MP0009745_abnormal_behavioral_response0.87867633
86MP0001963_abnormal_hearing_physiology0.87003173
87MP0000538_abnormal_urinary_bladder0.86643579
88MP0005310_abnormal_salivary_gland0.84726767
89MP0002752_abnormal_somatic_nervous0.84254312
90MP0009703_decreased_birth_body0.83166486
91MP0000026_abnormal_inner_ear0.83028170
92MP0002095_abnormal_skin_pigmentation0.82510559
93MP0010386_abnormal_urinary_bladder0.81407208
94MP0006035_abnormal_mitochondrial_morpho0.80951622
95MP0005670_abnormal_white_adipose0.80645664
96MP0003938_abnormal_ear_development0.80076728
97MP0005379_endocrine/exocrine_gland_phen0.78358057
98MP0005195_abnormal_posterior_eye0.76691299
99MP0002229_neurodegeneration0.76288134
100MP0004085_abnormal_heartbeat0.75525927

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.84870764
2Nephronophthisis (HP:0000090)3.83879981
3Hyperventilation (HP:0002883)3.82724758
4Chronic hepatic failure (HP:0100626)3.82699787
5Pancreatic fibrosis (HP:0100732)3.67491637
6Tubulointerstitial nephritis (HP:0001970)3.66270656
7True hermaphroditism (HP:0010459)3.55976811
8Abnormality of the renal medulla (HP:0100957)3.32653104
9Molar tooth sign on MRI (HP:0002419)3.14880259
10Abnormality of midbrain morphology (HP:0002418)3.14880259
11Medial flaring of the eyebrow (HP:0010747)3.06214455
12Colon cancer (HP:0003003)2.88621615
13Abnormality of the labia minora (HP:0012880)2.88529118
14Optic nerve hypoplasia (HP:0000609)2.72053189
15Gait imbalance (HP:0002141)2.71015994
16Congenital primary aphakia (HP:0007707)2.68970182
17Nephrogenic diabetes insipidus (HP:0009806)2.58354144
18Genital tract atresia (HP:0001827)2.51497267
19Drooling (HP:0002307)2.51345301
20Aplasia/Hypoplasia of the tongue (HP:0010295)2.48383616
21Gonadotropin excess (HP:0000837)2.47816083
22Vaginal atresia (HP:0000148)2.47662051
23Abnormality of the renal cortex (HP:0011035)2.47389330
24Cerebellar dysplasia (HP:0007033)2.41386537
25Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.34068012
26Cystic liver disease (HP:0006706)2.33862567
27Attenuation of retinal blood vessels (HP:0007843)2.33832670
28Pendular nystagmus (HP:0012043)2.30995431
29Gaze-evoked nystagmus (HP:0000640)2.26587437
30Excessive salivation (HP:0003781)2.26340296
31Methylmalonic acidemia (HP:0002912)2.25437332
32Absent speech (HP:0001344)2.23285613
33Febrile seizures (HP:0002373)2.19516387
34Abnormality of the parathyroid morphology (HP:0011766)2.19336173
35Bile duct proliferation (HP:0001408)2.17476332
36Abnormal biliary tract physiology (HP:0012439)2.17476332
37Postaxial hand polydactyly (HP:0001162)2.14735924
38Ependymoma (HP:0002888)2.10240962
393-Methylglutaconic aciduria (HP:0003535)2.07544265
40Tubular atrophy (HP:0000092)2.06514914
41Volvulus (HP:0002580)2.04916745
42Tubulointerstitial abnormality (HP:0001969)2.04599443
43Postaxial foot polydactyly (HP:0001830)2.04484885
44Calf muscle hypertrophy (HP:0008981)2.03256177
45Narrow forehead (HP:0000341)2.02628791
46Renal cortical cysts (HP:0000803)2.02151474
47Aplasia/Hypoplasia of the tibia (HP:0005772)1.98534516
48Broad-based gait (HP:0002136)1.95750366
49Poor coordination (HP:0002370)1.95468105
50Mitochondrial inheritance (HP:0001427)1.95337577
51Congenital hepatic fibrosis (HP:0002612)1.95247865
52Methylmalonic aciduria (HP:0012120)1.94687861
53Male pseudohermaphroditism (HP:0000037)1.94646815
54Type II lissencephaly (HP:0007260)1.93926747
55Anencephaly (HP:0002323)1.93833236
56Atonic seizures (HP:0010819)1.92417516
57Abnormality of macular pigmentation (HP:0008002)1.92311473
58Protruding tongue (HP:0010808)1.91780122
59Septo-optic dysplasia (HP:0100842)1.90346340
60Intestinal atresia (HP:0011100)1.89889406
61Growth hormone deficiency (HP:0000824)1.89112682
62Hepatoblastoma (HP:0002884)1.89039068
63Abolished electroretinogram (ERG) (HP:0000550)1.88613256
64Inability to walk (HP:0002540)1.87965336
65Hyperglycinuria (HP:0003108)1.87844744
66Abnormality of the astrocytes (HP:0100707)1.86811311
67Astrocytoma (HP:0009592)1.86811311
68Focal motor seizures (HP:0011153)1.86495108
69Broad foot (HP:0001769)1.85889300
70Abnormality of the axillary hair (HP:0100134)1.85395716
71Abnormality of secondary sexual hair (HP:0009888)1.85395716
72Hyperglycinemia (HP:0002154)1.85325111
73Dialeptic seizures (HP:0011146)1.85163284
74Widely spaced teeth (HP:0000687)1.84439824
75Glioma (HP:0009733)1.83276517
76Progressive cerebellar ataxia (HP:0002073)1.82302106
77Occipital encephalocele (HP:0002085)1.81980262
78Hypoplastic iliac wings (HP:0002866)1.80912009
79Astigmatism (HP:0000483)1.80778354
80Acute necrotizing encephalopathy (HP:0006965)1.80741640
81Sclerocornea (HP:0000647)1.80256110
82Aqueductal stenosis (HP:0002410)1.79571507
83Stomach cancer (HP:0012126)1.78982114
84Genetic anticipation (HP:0003743)1.77947353
85Muscle hypertrophy of the lower extremities (HP:0008968)1.72288193
86Abnormality of chromosome stability (HP:0003220)1.70700554
87Thyroid-stimulating hormone excess (HP:0002925)1.68664018
88Prostate neoplasm (HP:0100787)1.68545964
89Abnormality of glycine metabolism (HP:0010895)1.68313156
90Abnormality of serine family amino acid metabolism (HP:0010894)1.68313156
91Sloping forehead (HP:0000340)1.67758576
92Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.67595696
93Short 1st metacarpal (HP:0010034)1.67595696
94Abnormality of the metopic suture (HP:0005556)1.66923897
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.65630717
96Abnormality of the ileum (HP:0001549)1.65506973
97Lissencephaly (HP:0001339)1.65204602
98Meckel diverticulum (HP:0002245)1.64301732
99Abnormality of the ischium (HP:0003174)1.64292345
100Dandy-Walker malformation (HP:0001305)1.64244629

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.07633941
2STK38L3.25937998
3WNK32.93222090
4BRSK22.80457269
5MAP4K22.59965548
6TNIK2.52115881
7NUAK12.51832217
8CASK2.41298517
9MAP3K42.38162820
10AKT32.30829283
11TRIM282.20696142
12BCR2.04639860
13CAMK1G2.01659372
14MKNK21.91796223
15INSRR1.78635263
16SRPK11.66397227
17EPHA41.61927644
18TNK21.60775283
19MAPK131.59509345
20CAMK1D1.59204675
21PLK41.56434504
22MKNK11.55290792
23MARK11.41931153
24PAK31.39134429
25MAP2K71.32503944
26FER1.31781277
27FGFR21.31022134
28PLK21.30126414
29PINK11.28417684
30ACVR1B1.27592014
31VRK11.27286915
32GRK11.26652149
33BMPR1B1.25847488
34VRK21.24110758
35ZAK1.20631224
36EIF2AK31.15082508
37PBK1.13499847
38DYRK21.12978451
39PNCK1.12636830
40OXSR11.12023182
41CSNK1G11.07193808
42ADRBK21.04538554
43ERBB31.04237334
44WEE11.01080476
45TAOK30.99921533
46CDK190.98362820
47DYRK30.96260867
48CSNK1G20.96148490
49OBSCN0.95330589
50BRD40.91964783
51RPS6KA40.87866715
52STK390.86578218
53BCKDK0.83879363
54CSNK1A1L0.83646766
55NLK0.82479969
56CAMK10.82434542
57PRKCE0.80206942
58EIF2AK10.79521976
59CSNK1G30.78548625
60PLK30.74416831
61CDK30.70910795
62WNK40.69404339
63STK380.67624212
64SGK20.65254566
65MAP2K40.62317129
66CDC70.60738914
67DYRK1A0.60689367
68NME10.59576333
69PKN10.59119187
70MINK10.56979665
71MST40.56822126
72DMPK0.54857687
73BRSK10.54584332
74TEC0.53689732
75RPS6KA50.52285495
76ATR0.49651262
77ATM0.49090294
78CAMKK20.47968722
79PIK3CG0.47512179
80EIF2AK20.47105533
81PRKG10.45575030
82PRKCG0.44825090
83STK160.44786174
84CSNK1D0.44440906
85TIE10.44405837
86DYRK1B0.43244048
87PRKAA10.40800751
88PRKAA20.40462977
89WNK10.40198371
90FGFR10.40193303
91LATS10.37432067
92SGK4940.36988116
93SGK2230.36988116
94PIK3CA0.36864816
95TAF10.36527191
96CSNK1A10.35537897
97PLK10.34939935
98MARK30.34751878
99PRKACA0.34651453
100ERBB20.33630755

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.57277648
2Propanoate metabolism_Homo sapiens_hsa006402.65336370
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.44083504
4RNA polymerase_Homo sapiens_hsa030202.42561679
5Fanconi anemia pathway_Homo sapiens_hsa034602.40244112
6Butanoate metabolism_Homo sapiens_hsa006502.35113007
7Homologous recombination_Homo sapiens_hsa034402.29227099
8Phototransduction_Homo sapiens_hsa047442.25793243
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.14393582
10Non-homologous end-joining_Homo sapiens_hsa034502.12323274
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11367130
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03777155
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97010164
14Nicotine addiction_Homo sapiens_hsa050331.94232734
15Selenocompound metabolism_Homo sapiens_hsa004501.89577876
16Protein export_Homo sapiens_hsa030601.88265803
17Basal transcription factors_Homo sapiens_hsa030221.79859769
18Nitrogen metabolism_Homo sapiens_hsa009101.71519166
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71158886
20RNA degradation_Homo sapiens_hsa030181.68764657
21Fatty acid biosynthesis_Homo sapiens_hsa000611.62226958
22Circadian rhythm_Homo sapiens_hsa047101.60727513
23Oxidative phosphorylation_Homo sapiens_hsa001901.59559861
24Linoleic acid metabolism_Homo sapiens_hsa005911.58426581
25Taste transduction_Homo sapiens_hsa047421.51027818
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47950213
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46442133
28Regulation of autophagy_Homo sapiens_hsa041401.45561160
29Peroxisome_Homo sapiens_hsa041461.42191519
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41647149
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39218693
32Olfactory transduction_Homo sapiens_hsa047401.36756678
33Steroid biosynthesis_Homo sapiens_hsa001001.34780637
34Tryptophan metabolism_Homo sapiens_hsa003801.34470777
35Fatty acid metabolism_Homo sapiens_hsa012121.33549421
36ABC transporters_Homo sapiens_hsa020101.31416421
37Parkinsons disease_Homo sapiens_hsa050121.24802029
38Ether lipid metabolism_Homo sapiens_hsa005651.20698712
39RNA transport_Homo sapiens_hsa030131.12618297
40Huntingtons disease_Homo sapiens_hsa050161.10845500
41Lysine degradation_Homo sapiens_hsa003101.03348382
42Base excision repair_Homo sapiens_hsa034101.02391734
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01795692
44Purine metabolism_Homo sapiens_hsa002301.00392778
45Caffeine metabolism_Homo sapiens_hsa002321.00240150
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.98200760
47Mismatch repair_Homo sapiens_hsa034300.97852618
48Hedgehog signaling pathway_Homo sapiens_hsa043400.97554211
49Fatty acid degradation_Homo sapiens_hsa000710.96427322
50beta-Alanine metabolism_Homo sapiens_hsa004100.95522879
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94857099
52Proteasome_Homo sapiens_hsa030500.93130596
53Spliceosome_Homo sapiens_hsa030400.88310298
54Retinol metabolism_Homo sapiens_hsa008300.86643448
55mRNA surveillance pathway_Homo sapiens_hsa030150.84893732
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82347428
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81753623
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80597046
59Collecting duct acid secretion_Homo sapiens_hsa049660.79097751
60Circadian entrainment_Homo sapiens_hsa047130.77706409
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76251302
62Nucleotide excision repair_Homo sapiens_hsa034200.72880103
63Pyrimidine metabolism_Homo sapiens_hsa002400.72363137
64Fatty acid elongation_Homo sapiens_hsa000620.69060608
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69007544
66Oocyte meiosis_Homo sapiens_hsa041140.68510838
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68153399
68Glutamatergic synapse_Homo sapiens_hsa047240.67495416
69GABAergic synapse_Homo sapiens_hsa047270.66588291
70DNA replication_Homo sapiens_hsa030300.66040090
71Chemical carcinogenesis_Homo sapiens_hsa052040.65270444
72Morphine addiction_Homo sapiens_hsa050320.64884017
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61611454
74Insulin secretion_Homo sapiens_hsa049110.61482342
75Long-term depression_Homo sapiens_hsa047300.61025712
76Metabolic pathways_Homo sapiens_hsa011000.59201176
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58974675
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57544414
79Serotonergic synapse_Homo sapiens_hsa047260.57015151
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.56373790
81Alzheimers disease_Homo sapiens_hsa050100.55877070
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55787288
83Arachidonic acid metabolism_Homo sapiens_hsa005900.55096577
84Dopaminergic synapse_Homo sapiens_hsa047280.53018720
85Cardiac muscle contraction_Homo sapiens_hsa042600.52537845
86Calcium signaling pathway_Homo sapiens_hsa040200.52063566
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48763533
88Wnt signaling pathway_Homo sapiens_hsa043100.44679218
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.44324767
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42285425
91Glycerolipid metabolism_Homo sapiens_hsa005610.41655081
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39162973
93Vitamin digestion and absorption_Homo sapiens_hsa049770.38835243
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35464329
95Salivary secretion_Homo sapiens_hsa049700.33495239
96One carbon pool by folate_Homo sapiens_hsa006700.32970513
97cAMP signaling pathway_Homo sapiens_hsa040240.32189361
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.31706011
99Basal cell carcinoma_Homo sapiens_hsa052170.30264437
100Amphetamine addiction_Homo sapiens_hsa050310.29604720

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