ZNF580

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)4.43244127
2negative regulation of erythrocyte differentiation (GO:0045647)4.41591816
3deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.17334951
4tooth mineralization (GO:0034505)4.05890774
5lymph vessel development (GO:0001945)4.02726208
6negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.00265224
7mannose metabolic process (GO:0006013)3.98306893
8regulation of mammary gland epithelial cell proliferation (GO:0033599)3.97528559
9GDP-mannose metabolic process (GO:0019673)3.91135580
10protein retention in ER lumen (GO:0006621)3.86138340
11protein insertion into membrane (GO:0051205)3.80533385
12UV protection (GO:0009650)3.72589310
13modulation by virus of host process (GO:0019054)3.66280888
14positive regulation of histone deacetylation (GO:0031065)3.54128980
15positive regulation of T cell apoptotic process (GO:0070234)3.48490536
16viral transcription (GO:0019083)3.46992900
17cranial nerve morphogenesis (GO:0021602)3.42765457
18regulation of apoptotic process involved in morphogenesis (GO:1902337)3.39837679
19positive regulation of protein sumoylation (GO:0033235)3.27104986
20negative regulation of cell size (GO:0045792)3.24843316
21cell-cell junction maintenance (GO:0045217)3.23455599
22cell migration in hindbrain (GO:0021535)3.20221449
23adenosine receptor signaling pathway (GO:0001973)3.18826399
24positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.15631424
25modulation by symbiont of host cellular process (GO:0044068)3.14831343
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.13708223
27regulation of early endosome to late endosome transport (GO:2000641)3.11561623
28apoptotic process involved in morphogenesis (GO:0060561)3.10746011
29ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.10560236
30phosphatidylglycerol biosynthetic process (GO:0006655)3.09084063
31positive regulation of lymphocyte apoptotic process (GO:0070230)3.08934858
32negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.03902577
33positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.03813409
34response to misfolded protein (GO:0051788)3.00994813
35establishment of mitochondrion localization (GO:0051654)2.97175062
36growth hormone secretion (GO:0030252)2.96976789
37amyloid precursor protein catabolic process (GO:0042987)2.96249994
38positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.93059565
39translational termination (GO:0006415)2.91585800
40regulation of histone deacetylation (GO:0031063)2.91117869
41activation of MAPKKK activity (GO:0000185)2.89431668
42establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.89325421
43mitochondrion transport along microtubule (GO:0047497)2.89325421
44pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.87945691
45NIK/NF-kappaB signaling (GO:0038061)2.86806572
46peptidyl-arginine omega-N-methylation (GO:0035247)2.83597685
47intracellular estrogen receptor signaling pathway (GO:0030520)2.83345663
48cellular response to virus (GO:0098586)2.76518266
49regulation of chromatin binding (GO:0035561)2.75974080
50positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.73799977
51regulation of hydrogen peroxide metabolic process (GO:0010310)2.73557405
52viral life cycle (GO:0019058)2.71154934
53retinoic acid receptor signaling pathway (GO:0048384)2.68650590
54negative regulation of DNA-templated transcription, elongation (GO:0032785)2.68456316
55viral protein processing (GO:0019082)2.68303988
56translational elongation (GO:0006414)2.67882818
57pentose metabolic process (GO:0019321)2.64587277
58negative regulation of cAMP-mediated signaling (GO:0043951)2.63408843
59cochlea morphogenesis (GO:0090103)2.63022761
60virion assembly (GO:0019068)2.62815617
61pyrimidine nucleotide catabolic process (GO:0006244)2.60756997
62modulation by virus of host morphology or physiology (GO:0019048)2.58728091
63regulation of synapse structural plasticity (GO:0051823)2.57468069
64histone H4 deacetylation (GO:0070933)2.57069344
65regulation of ARF GTPase activity (GO:0032312)2.56251563
66skeletal muscle organ development (GO:0060538)2.55450478
67positive regulation of protein kinase C signaling (GO:0090037)2.54075693
68barbed-end actin filament capping (GO:0051016)2.52287421
69regulation of response to osmotic stress (GO:0047484)2.51891153
70positive regulation of protein deacetylation (GO:0090312)2.51785316
71outflow tract septum morphogenesis (GO:0003148)2.51029408
72histone H3 deacetylation (GO:0070932)2.50942188
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.50536338
74vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.48037479
75positive regulation of TOR signaling (GO:0032008)2.46979291
76nuclear envelope reassembly (GO:0031468)2.45989866
77mitotic nuclear envelope reassembly (GO:0007084)2.45989866
78retrograde transport, endosome to Golgi (GO:0042147)2.43837154
79iron-sulfur cluster assembly (GO:0016226)2.42017709
80metallo-sulfur cluster assembly (GO:0031163)2.42017709
81response to acidic pH (GO:0010447)2.41327772
82granulocyte differentiation (GO:0030851)2.40710784
83stress fiber assembly (GO:0043149)2.40397149
84mammary gland epithelial cell differentiation (GO:0060644)2.40357869
85negative regulation of myeloid cell apoptotic process (GO:0033033)2.40098771
86purine deoxyribonucleotide catabolic process (GO:0009155)2.39862010
87positive regulation of synapse maturation (GO:0090129)2.39067353
88positive regulation of muscle cell apoptotic process (GO:0010661)2.38949763
89synaptic vesicle exocytosis (GO:0016079)2.38802005
90nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.38139522
913-UTR-mediated mRNA stabilization (GO:0070935)2.37792242
92base-excision repair, AP site formation (GO:0006285)2.36461364
93regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.36014800
94planar cell polarity pathway involved in neural tube closure (GO:0090179)2.35945279
95muscle organ morphogenesis (GO:0048644)2.35885046
96negative regulation of tumor necrosis factor production (GO:0032720)2.35386295
97diaphragm development (GO:0060539)2.34942792
98semaphorin-plexin signaling pathway (GO:0071526)2.33641717
99cardiac muscle cell proliferation (GO:0060038)2.32589402
100response to peptidoglycan (GO:0032494)2.31304626

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.24709738
2LXR_22292898_ChIP-Seq_THP-1_Human3.05027577
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.93830968
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.79199369
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.68198820
6MYC_22102868_ChIP-Seq_BL_Human2.46120564
7* ELK3_25401928_ChIP-Seq_HUVEC_Human2.33345966
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.29364975
9P68_20966046_ChIP-Seq_HELA_Human2.20205150
10* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.18157428
11TET1_21451524_ChIP-Seq_MESCs_Mouse2.13768288
12KDM2B_26808549_Chip-Seq_DND41_Human2.12996973
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.07760515
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02867369
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01043143
16RACK7_27058665_Chip-Seq_MCF-7_Human1.96768834
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.96668828
18ERG_21242973_ChIP-ChIP_JURKAT_Human1.89093841
19SRY_22984422_ChIP-ChIP_TESTIS_Rat1.85018152
20CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.83743072
21SA1_27219007_Chip-Seq_ERYTHROID_Human1.82470258
22ELF1_20517297_ChIP-Seq_JURKAT_Human1.80853234
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80673434
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74175661
25KDM2B_26808549_Chip-Seq_K562_Human1.73912817
26MAF_26560356_Chip-Seq_TH2_Human1.73600408
27CTCF_27219007_Chip-Seq_ERYTHROID_Human1.73016994
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70473345
29XRN2_22483619_ChIP-Seq_HELA_Human1.70015740
30SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.69458425
31* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.69021773
32BCL6_27268052_Chip-Seq_Bcells_Human1.68971840
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67092014
34* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65782296
35TCF7_22412390_ChIP-Seq_EML_Mouse1.60590913
36CTCF_27219007_Chip-Seq_Bcells_Human1.58202409
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57602429
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55266581
39SMC4_20622854_ChIP-Seq_HELA_Human1.53175326
40SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52772255
41KDM2B_26808549_Chip-Seq_JURKAT_Human1.52394714
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52190718
43VDR_24763502_ChIP-Seq_THP-1_Human1.51656207
44BCOR_27268052_Chip-Seq_Bcells_Human1.51579025
45CREB1_26743006_Chip-Seq_LNCaP_Human1.48054566
46UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44866844
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42436367
48* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.38925540
49* MAF_26560356_Chip-Seq_TH1_Human1.38836771
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37591618
51* FOXP1_21924763_ChIP-Seq_HESCs_Human1.37117077
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36986926
53PHF8_20622854_ChIP-Seq_HELA_Human1.34542746
54E2F1_20622854_ChIP-Seq_HELA_Human1.33173712
55* UTX_26944678_Chip-Seq_JUKART_Human1.33013556
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30410853
57CTCF_18555785_ChIP-Seq_MESCs_Mouse1.29793909
58CTCF_26484167_Chip-Seq_Bcells_Mouse1.29617438
59SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.29255332
60* CTCF_21964334_Chip-Seq_Bcells_Human1.28704423
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27237673
62SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26807773
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25655909
64TP53_22127205_ChIP-Seq_IMR90_Human1.24789770
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24076032
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23238400
67RARB_24833708_ChIP-Seq_LIVER_Mouse1.22210819
68SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.21179757
69JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20758848
70SA1_27219007_Chip-Seq_Bcells_Human1.19758626
71CTCF_20526341_ChIP-Seq_ESCs_Human1.19496768
72RARA_24833708_ChIP-Seq_LIVER_Mouse1.19000530
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.16753033
74YY1_22570637_ChIP-Seq_MALME-3M_Human1.15833175
75* NCOR1_26117541_ChIP-Seq_K562_Human1.14755687
76MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14226933
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13887784
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13849092
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13474091
80* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13061223
81CIITA_25753668_ChIP-Seq_RAJI_Human1.11797223
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11437649
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10574727
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06568435
85* GABP_19822575_ChIP-Seq_HepG2_Human1.06554431
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06105728
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05912181
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.05718154
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04722337
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04084682
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04058341
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04046887
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03492554
94JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01832080
95STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.01615594
96ZNF263_19887448_ChIP-Seq_K562_Human1.00937533
97ETS1_21867929_ChIP-Seq_TH2_Mouse1.00836643
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98823247
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98408933
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97810254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.65889681
2MP0002249_abnormal_larynx_morphology3.47042718
3MP0004858_abnormal_nervous_system3.18540673
4MP0005623_abnormal_meninges_morphology2.70720523
5MP0001188_hyperpigmentation2.55092335
6MP0003172_abnormal_lysosome_physiology2.48230025
7MP0000678_abnormal_parathyroid_gland2.41007482
8MP0003123_paternal_imprinting2.37218451
9MP0003303_peritoneal_inflammation2.34921095
10MP0003705_abnormal_hypodermis_morpholog2.29389485
11MP0009278_abnormal_bone_marrow2.22065258
12MP0003279_aneurysm2.18449304
13MP0005423_abnormal_somatic_nervous2.17044422
14MP0004859_abnormal_synaptic_plasticity2.09237062
15MP0002653_abnormal_ependyma_morphology2.03682395
16MP0003436_decreased_susceptibility_to1.97758262
17MP0000003_abnormal_adipose_tissue1.82513975
18MP0003879_abnormal_hair_cell1.77689039
19MP0000681_abnormal_thyroid_gland1.68144315
20MP0003329_amyloid_beta_deposits1.63922527
21MP0000049_abnormal_middle_ear1.61585002
22MP0004510_myositis1.61505826
23MP0004185_abnormal_adipocyte_glucose1.61291182
24MP0001270_distended_abdomen1.61113659
25MP0010030_abnormal_orbit_morphology1.60536705
26MP0008260_abnormal_autophagy1.57953433
27MP0002163_abnormal_gland_morphology1.57952483
28MP0001502_abnormal_circadian_rhythm1.57925938
29MP0005375_adipose_tissue_phenotype1.57755776
30MP0000750_abnormal_muscle_regeneration1.55092576
31MP0009333_abnormal_splenocyte_physiolog1.44371236
32MP0002822_catalepsy1.42271319
33MP0005076_abnormal_cell_differentiation1.39241096
34MP0001348_abnormal_lacrimal_gland1.34971439
35MP0005666_abnormal_adipose_tissue1.34459988
36MP0000751_myopathy1.33359679
37MP0009840_abnormal_foam_cell1.29976183
38MP0005409_darkened_coat_color1.21331418
39MP0009384_cardiac_valve_regurgitation1.19027139
40MP0001958_emphysema1.18658849
41MP0005670_abnormal_white_adipose1.18264692
42MP0003942_abnormal_urinary_system1.17783556
43MP0000013_abnormal_adipose_tissue1.16661360
44MP0002932_abnormal_joint_morphology1.14695089
45MP0005499_abnormal_olfactory_system1.14432192
46MP0005394_taste/olfaction_phenotype1.14432192
47MP0001905_abnormal_dopamine_level1.13889191
48MP0005501_abnormal_skin_physiology1.12244053
49MP0005451_abnormal_body_composition1.09811177
50MP0001986_abnormal_taste_sensitivity1.08829501
51MP0005503_abnormal_tendon_morphology1.08402777
52MP0003453_abnormal_keratinocyte_physiol0.98363473
53MP0001346_abnormal_lacrimal_gland0.97239382
54MP0009379_abnormal_foot_pigmentation0.96800061
55MP0000733_abnormal_muscle_development0.93259213
56MP0001968_abnormal_touch/_nociception0.93042653
57MP0003635_abnormal_synaptic_transmissio0.92333787
58MP0000858_altered_metastatic_potential0.90672591
59MP0000685_abnormal_immune_system0.90121217
60MP0002063_abnormal_learning/memory/cond0.90046440
61MP0004130_abnormal_muscle_cell0.88308293
62MP0005508_abnormal_skeleton_morphology0.84492693
63MP0002877_abnormal_melanocyte_morpholog0.84346020
64MP0000604_amyloidosis0.84146682
65MP0005025_abnormal_response_to0.81713098
66MP0001849_ear_inflammation0.81711281
67MP0005397_hematopoietic_system_phenotyp0.81554377
68MP0001545_abnormal_hematopoietic_system0.81554377
69MP0005390_skeleton_phenotype0.81485924
70MP0000343_altered_response_to0.80832869
71MP0001790_abnormal_immune_system0.80049414
72MP0005387_immune_system_phenotype0.80049414
73MP0008874_decreased_physiological_sensi0.79689948
74MP0000759_abnormal_skeletal_muscle0.79140685
75MP0005379_endocrine/exocrine_gland_phen0.79078880
76MP0002733_abnormal_thermal_nociception0.78291181
77MP0002933_joint_inflammation0.77752571
78MP0004811_abnormal_neuron_physiology0.77050242
79MP0002234_abnormal_pharynx_morphology0.77048075
80MP0001970_abnormal_pain_threshold0.76370139
81MP0005257_abnormal_intraocular_pressure0.76040590
82MP0009250_abnormal_appendicular_skeleto0.72545753
83MP0009053_abnormal_anal_canal0.71640755
84MP0003634_abnormal_glial_cell0.69152061
85MP0001873_stomach_inflammation0.67217830
86MP0002116_abnormal_craniofacial_bone0.67202729
87MP0006036_abnormal_mitochondrial_physio0.66198793
88MP0005000_abnormal_immune_tolerance0.65295423
89MP0002723_abnormal_immune_serum0.65281774
90MP0001542_abnormal_bone_strength0.64696282
91MP0000026_abnormal_inner_ear0.64636175
92MP0000767_abnormal_smooth_muscle0.64540849
93MP0008789_abnormal_olfactory_epithelium0.64258328
94MP0000955_abnormal_spinal_cord0.64210214
95MP0002114_abnormal_axial_skeleton0.63507180
96MP0002398_abnormal_bone_marrow0.58886604
97MP0002420_abnormal_adaptive_immunity0.58760992
98MP0002429_abnormal_blood_cell0.58122761
99MP0003075_altered_response_to0.58067819
100MP0000703_abnormal_thymus_morphology0.58018338

Predicted human phenotypes

RankGene SetZ-score
1Hyperthyroidism (HP:0000836)3.58062094
2Broad distal phalanx of finger (HP:0009836)3.51977680
3Double outlet right ventricle (HP:0001719)3.48856842
4Congenital malformation of the right heart (HP:0011723)3.48856842
5Truncus arteriosus (HP:0001660)3.41840505
6Annular pancreas (HP:0001734)3.11465397
7Ulnar bowing (HP:0003031)3.06625758
8Testicular atrophy (HP:0000029)3.04280144
9Abnormality of the aortic arch (HP:0012303)3.01794423
10Atelectasis (HP:0100750)2.98448046
11Hypertensive crisis (HP:0100735)2.96766515
12Obstructive sleep apnea (HP:0002870)2.91606969
13Thin bony cortex (HP:0002753)2.87289089
14Stridor (HP:0010307)2.82015204
15Joint stiffness (HP:0001387)2.81582361
16Hyperacusis (HP:0010780)2.71979872
17Emphysema (HP:0002097)2.59222460
18Genu recurvatum (HP:0002816)2.58633201
19Increased muscle lipid content (HP:0009058)2.46438445
20Vertebral compression fractures (HP:0002953)2.45370359
21Turricephaly (HP:0000262)2.42414499
22Long palpebral fissure (HP:0000637)2.41514100
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.41041979
24Supranuclear gaze palsy (HP:0000605)2.38441418
25Hemorrhage of the eye (HP:0011885)2.37692371
26Hypercortisolism (HP:0001578)2.37474772
27Dysostosis multiplex (HP:0000943)2.37155303
28Abnormality of cells of the erythroid lineage (HP:0012130)2.36292619
29Abnormality of mucopolysaccharide metabolism (HP:0011020)2.32536893
30Abnormality of polysaccharide metabolism (HP:0011012)2.32536893
31Abnormality of glycosaminoglycan metabolism (HP:0004371)2.32536893
32Mesangial abnormality (HP:0001966)2.32019765
33Myopathic facies (HP:0002058)2.29982019
34Deep palmar crease (HP:0006191)2.24283260
35Chronic obstructive pulmonary disease (HP:0006510)2.21198697
36Obstructive lung disease (HP:0006536)2.21198697
37Achilles tendon contracture (HP:0001771)2.20219651
38Ragged-red muscle fibers (HP:0003200)2.19779161
39Purpura (HP:0000979)2.19404870
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19298208
41Abnormal number of erythroid precursors (HP:0012131)2.17373233
42Biconcave vertebral bodies (HP:0004586)2.16083765
43Microretrognathia (HP:0000308)2.15892725
44Squamous cell carcinoma (HP:0002860)2.15765971
45Rib fusion (HP:0000902)2.13164869
46Slender long bone (HP:0003100)2.12192049
47Mucopolysacchariduria (HP:0008155)2.11347751
48Urinary glycosaminoglycan excretion (HP:0003541)2.11347751
49Amblyopia (HP:0000646)2.09292376
50Increased intramyocellular lipid droplets (HP:0012240)2.07732889
51Rectal prolapse (HP:0002035)2.07570725
52Seborrheic dermatitis (HP:0001051)2.07069494
53Abnormality of the phalanges of the hallux (HP:0010057)2.06764651
54Renal Fanconi syndrome (HP:0001994)2.06697297
55Insomnia (HP:0100785)2.02952838
56Mitral regurgitation (HP:0001653)2.02067083
57Cervical subluxation (HP:0003308)1.99801023
58Protrusio acetabuli (HP:0003179)1.99285245
59Intestinal fistula (HP:0100819)1.98212261
60Vaginal fistula (HP:0004320)1.97842842
61Microvesicular hepatic steatosis (HP:0001414)1.96291573
62Growth hormone excess (HP:0000845)1.95315841
63Hyperparathyroidism (HP:0000843)1.94929539
64Cholelithiasis (HP:0001081)1.94086063
65Poikiloderma (HP:0001029)1.94048129
66Pulmonary artery stenosis (HP:0004415)1.92832831
67Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.90780384
68Prolonged neonatal jaundice (HP:0006579)1.89785483
69Transposition of the great arteries (HP:0001669)1.88484521
70Abnormal connection of the cardiac segments (HP:0011545)1.88484521
71Abnormal ventriculo-arterial connection (HP:0011563)1.88484521
72Petechiae (HP:0000967)1.88171608
73Abnormality of the gallbladder (HP:0005264)1.88155478
74Easy fatigability (HP:0003388)1.86306186
75Abnormality of the nasal mucosa (HP:0000433)1.85842762
76Hypoplastic left heart (HP:0004383)1.85647225
77Distal upper limb amyotrophy (HP:0007149)1.85302473
78Upper limb amyotrophy (HP:0009129)1.85302473
79Rectal fistula (HP:0100590)1.84911302
80Rectovaginal fistula (HP:0000143)1.84911302
81Abnormal gallbladder physiology (HP:0012438)1.83073942
82Cholecystitis (HP:0001082)1.83073942
83Abnormality of glycosphingolipid metabolism (HP:0004343)1.81128353
84Abnormality of glycolipid metabolism (HP:0010969)1.81128353
85Abnormality of liposaccharide metabolism (HP:0010968)1.81128353
86Abnormality of the Achilles tendon (HP:0005109)1.80317579
87Recurrent bacterial skin infections (HP:0005406)1.79417321
88Pointed chin (HP:0000307)1.78590635
89Gastrointestinal stroma tumor (HP:0100723)1.78188435
90Breast hypoplasia (HP:0003187)1.78082694
91Neuronal loss in central nervous system (HP:0002529)1.77725650
92Disproportionate tall stature (HP:0001519)1.76734241
93Renal dysplasia (HP:0000110)1.75627863
94Polygenic inheritance (HP:0010982)1.74743536
95Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73987714
96Venous insufficiency (HP:0005293)1.73161334
97Spinal canal stenosis (HP:0003416)1.72487444
98Optic nerve coloboma (HP:0000588)1.71742561
99Hypoplastic heart (HP:0001961)1.71674696
100Abnormality of the tricuspid valve (HP:0001702)1.70281972

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.00134872
2ERN13.48163409
3SMG13.23283015
4NME23.05469085
5PRPF4B2.90503907
6MAP3K112.87498604
7SIK12.56361895
8ICK2.35757743
9ARAF2.16424187
10IRAK32.10124117
11VRK22.08923614
12SIK22.02185792
13PRKD31.97019502
14TAOK21.91820630
15STK161.83036613
16MAP2K31.81890539
17PIM21.60261577
18TESK11.55946257
19MAP4K11.52948907
20BRAF1.49813626
21MARK21.48398261
22PRKD21.41709658
23TESK21.40441725
24HIPK21.25866618
25BCKDK1.23316803
26TAOK11.17681747
27MAPK151.13794376
28CDC42BPA1.13546364
29TNK21.13388321
30IRAK21.12452833
31SIK31.11592896
32IRAK41.05557774
33MAP3K131.05533835
34PKN21.03618700
35RPS6KA21.02623139
36MAP3K11.02405332
37CDK121.02272735
38DYRK1B1.00719653
39TBK10.99288544
40GRK60.94744190
41RPS6KC10.92024311
42RPS6KL10.92024311
43CAMKK10.90863291
44RIPK40.88397150
45BLK0.86243766
46EEF2K0.86096411
47DYRK30.85594694
48MAP3K100.85085100
49PDPK10.79173517
50MAPK120.77956378
51LRRK20.77551019
52KDR0.76093835
53IKBKB0.75330484
54RPS6KA60.74794498
55EPHB20.72737540
56ILK0.71637325
57MAP2K40.69866447
58DAPK30.69156946
59CDK190.68366539
60CDK11A0.65275225
61MTOR0.65079431
62MAP2K20.64556437
63KSR20.64344864
64TYK20.63606116
65MAPK110.62355261
66EPHB10.61864495
67ABL20.61853218
68DYRK20.61408190
69CDK40.60667771
70MAP3K30.57820362
71CSNK1G30.57018185
72CDK150.56904718
73LIMK10.55528759
74DDR20.54586945
75GRK50.52754891
76DMPK0.52739717
77STK110.52641527
78BMX0.52107064
79CAMK1D0.51725333
80MAPK70.51576479
81AURKA0.51012643
82DAPK10.48192924
83CDK180.47506629
84CDK140.47489774
85PTK60.47365789
86MAP3K60.47345174
87PAK10.46575762
88CSNK1A1L0.46344392
89MAPK40.46256705
90UHMK10.44519520
91TAF10.44457065
92CDK90.43604524
93MAP2K60.42724841
94ZAP700.41897191
95CDK70.35329510
96PDK10.34902932
97BRSK10.34810912
98CSK0.34800114
99MAPK80.34109137
100PRKCH0.33358994

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041225.09530670
2Other glycan degradation_Homo sapiens_hsa005113.31852280
3Notch signaling pathway_Homo sapiens_hsa043303.05677451
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.74808875
5Ribosome_Homo sapiens_hsa030102.38938131
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.16891012
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.03959743
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.99463414
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.84283477
10Acute myeloid leukemia_Homo sapiens_hsa052211.83076135
11VEGF signaling pathway_Homo sapiens_hsa043701.82321139
12Synaptic vesicle cycle_Homo sapiens_hsa047211.80522438
13Bladder cancer_Homo sapiens_hsa052191.75269091
14Neurotrophin signaling pathway_Homo sapiens_hsa047221.56572063
15Fructose and mannose metabolism_Homo sapiens_hsa000511.50344180
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48648845
17Non-small cell lung cancer_Homo sapiens_hsa052231.46985353
18Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.40977420
19mTOR signaling pathway_Homo sapiens_hsa041501.40288740
20B cell receptor signaling pathway_Homo sapiens_hsa046621.38469955
21Vibrio cholerae infection_Homo sapiens_hsa051101.38170158
22Prion diseases_Homo sapiens_hsa050201.37123151
23Chronic myeloid leukemia_Homo sapiens_hsa052201.37060945
24Lysosome_Homo sapiens_hsa041421.35100239
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15745686
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12109197
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10681144
28Osteoclast differentiation_Homo sapiens_hsa043801.09968948
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.07909973
30Endocytosis_Homo sapiens_hsa041441.01977550
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01259325
32Cocaine addiction_Homo sapiens_hsa050300.98498509
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97594629
34Pancreatic cancer_Homo sapiens_hsa052120.95886398
35Collecting duct acid secretion_Homo sapiens_hsa049660.93553140
36Pentose phosphate pathway_Homo sapiens_hsa000300.92829906
37Base excision repair_Homo sapiens_hsa034100.92290978
38Glioma_Homo sapiens_hsa052140.89688811
39Endometrial cancer_Homo sapiens_hsa052130.89599994
40Galactose metabolism_Homo sapiens_hsa000520.88222778
41Tuberculosis_Homo sapiens_hsa051520.87227687
42AMPK signaling pathway_Homo sapiens_hsa041520.86709060
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85645898
44Basal cell carcinoma_Homo sapiens_hsa052170.85577914
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84366944
46GnRH signaling pathway_Homo sapiens_hsa049120.84116267
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.82290847
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.82189621
49Sphingolipid signaling pathway_Homo sapiens_hsa040710.79702311
50Insulin signaling pathway_Homo sapiens_hsa049100.78518007
51Oxidative phosphorylation_Homo sapiens_hsa001900.78198764
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.75823681
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75485114
54Hepatitis B_Homo sapiens_hsa051610.75164633
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74884435
56Leishmaniasis_Homo sapiens_hsa051400.74392550
57Colorectal cancer_Homo sapiens_hsa052100.70587074
58Primary immunodeficiency_Homo sapiens_hsa053400.70326795
59ErbB signaling pathway_Homo sapiens_hsa040120.69908040
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69311523
61HTLV-I infection_Homo sapiens_hsa051660.68238100
62Parkinsons disease_Homo sapiens_hsa050120.67736323
63MAPK signaling pathway_Homo sapiens_hsa040100.67293838
64Apoptosis_Homo sapiens_hsa042100.66246935
65Salmonella infection_Homo sapiens_hsa051320.66206216
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65961284
67Melanogenesis_Homo sapiens_hsa049160.65854600
68Hedgehog signaling pathway_Homo sapiens_hsa043400.65202754
69Cholinergic synapse_Homo sapiens_hsa047250.65144537
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61624780
71Biosynthesis of amino acids_Homo sapiens_hsa012300.58406318
72Chemokine signaling pathway_Homo sapiens_hsa040620.58074444
73Hepatitis C_Homo sapiens_hsa051600.57434184
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.57007175
75Inositol phosphate metabolism_Homo sapiens_hsa005620.56578618
76Herpes simplex infection_Homo sapiens_hsa051680.56388824
77Huntingtons disease_Homo sapiens_hsa050160.56381123
78TNF signaling pathway_Homo sapiens_hsa046680.56346121
79Pyrimidine metabolism_Homo sapiens_hsa002400.54930024
80Choline metabolism in cancer_Homo sapiens_hsa052310.53269088
81Axon guidance_Homo sapiens_hsa043600.52726226
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52485542
83Epstein-Barr virus infection_Homo sapiens_hsa051690.52388157
84Shigellosis_Homo sapiens_hsa051310.51436853
85Malaria_Homo sapiens_hsa051440.49673265
86Prolactin signaling pathway_Homo sapiens_hsa049170.48585421
87Renal cell carcinoma_Homo sapiens_hsa052110.48330470
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47803662
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46129772
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45768121
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45284276
92Dopaminergic synapse_Homo sapiens_hsa047280.45035362
93Sphingolipid metabolism_Homo sapiens_hsa006000.44743511
94Alzheimers disease_Homo sapiens_hsa050100.41448435
95Toxoplasmosis_Homo sapiens_hsa051450.40355634
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39257034
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.38793467
98Estrogen signaling pathway_Homo sapiens_hsa049150.38460911
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37779086
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37490868

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