ZNF581

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.39372322
2ribosomal small subunit assembly (GO:0000028)6.22901108
3viral transcription (GO:0019083)6.21715699
4translational termination (GO:0006415)5.92541619
5maturation of SSU-rRNA (GO:0030490)5.36840645
6translational elongation (GO:0006414)5.31029386
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.08750904
8formation of translation preinitiation complex (GO:0001731)5.00380826
9nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.96838883
10cotranslational protein targeting to membrane (GO:0006613)4.94788221
11protein targeting to ER (GO:0045047)4.90938290
12translational initiation (GO:0006413)4.84680357
13viral life cycle (GO:0019058)4.80402052
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.67284181
15ribosomal large subunit biogenesis (GO:0042273)4.67142693
16protein localization to endoplasmic reticulum (GO:0070972)4.64216383
17cellular protein complex disassembly (GO:0043624)4.49637965
18ribonucleoprotein complex biogenesis (GO:0022613)4.39557679
19protein complex disassembly (GO:0043241)4.07050272
20chaperone-mediated protein transport (GO:0072321)3.99978899
21translation (GO:0006412)3.96739216
22pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.89247142
23macromolecular complex disassembly (GO:0032984)3.83782176
24rRNA modification (GO:0000154)3.74902504
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.72608039
26ribosome biogenesis (GO:0042254)3.70068160
27nuclear-transcribed mRNA catabolic process (GO:0000956)3.63535600
28rRNA processing (GO:0006364)3.62236247
29regulation of mitochondrial translation (GO:0070129)3.56891081
30cellular component biogenesis (GO:0044085)3.56340296
31transcription from mitochondrial promoter (GO:0006390)3.53254616
32base-excision repair, AP site formation (GO:0006285)3.52631191
33protein targeting to membrane (GO:0006612)3.48335808
34mRNA catabolic process (GO:0006402)3.45127673
35rRNA metabolic process (GO:0016072)3.44286730
36deoxyribonucleotide catabolic process (GO:0009264)3.36319964
37protein targeting to mitochondrion (GO:0006626)3.35893132
38RNA catabolic process (GO:0006401)3.31483707
39DNA strand elongation involved in DNA replication (GO:0006271)3.31067770
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.30064191
41DNA strand elongation (GO:0022616)3.27773900
42pyrimidine nucleotide catabolic process (GO:0006244)3.25701069
43deoxyribose phosphate catabolic process (GO:0046386)3.25488360
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.23298446
45termination of RNA polymerase III transcription (GO:0006386)3.23298446
46peptidyl-histidine modification (GO:0018202)3.20558693
47telomere maintenance via semi-conservative replication (GO:0032201)3.16903513
48proteasome assembly (GO:0043248)3.16451179
49spliceosomal snRNP assembly (GO:0000387)3.16246310
50establishment of integrated proviral latency (GO:0075713)3.14232641
51purine nucleobase biosynthetic process (GO:0009113)3.14197085
52purine deoxyribonucleotide catabolic process (GO:0009155)3.13799830
53pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.12856033
54establishment of protein localization to mitochondrion (GO:0072655)3.12316109
55rRNA methylation (GO:0031167)3.12254451
56negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12005198
57protein maturation by protein folding (GO:0022417)3.11050388
58IMP biosynthetic process (GO:0006188)3.05072904
59guanosine-containing compound biosynthetic process (GO:1901070)3.03320817
60pentose metabolic process (GO:0019321)3.01766034
61ribosome assembly (GO:0042255)3.01014110
62DNA replication checkpoint (GO:0000076)2.99580859
63pseudouridine synthesis (GO:0001522)2.98137304
64pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.97906029
65establishment of viral latency (GO:0019043)2.95747692
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94270754
67protein localization to mitochondrion (GO:0070585)2.93286181
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92415260
69negative regulation of ligase activity (GO:0051352)2.92415260
70ncRNA 3-end processing (GO:0043628)2.91798415
71DNA unwinding involved in DNA replication (GO:0006268)2.89558228
72RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89472173
73tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89472173
74nucleobase biosynthetic process (GO:0046112)2.88684139
75mitotic metaphase plate congression (GO:0007080)2.86344728
76rRNA transcription (GO:0009303)2.86298965
77iron-sulfur cluster assembly (GO:0016226)2.85367944
78metallo-sulfur cluster assembly (GO:0031163)2.85367944
79ncRNA processing (GO:0034470)2.85100198
80negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.84881883
81nucleotide salvage (GO:0043173)2.84462223
82pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.84282621
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82117984
84mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.81976709
85base-excision repair (GO:0006284)2.81619992
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81311602
87chromatin remodeling at centromere (GO:0031055)2.80522827
88negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.79190469
89CENP-A containing nucleosome assembly (GO:0034080)2.78161719
90histone arginine methylation (GO:0034969)2.78148843
91pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.76455179
92negative regulation of RNA splicing (GO:0033119)2.76284242
93L-serine metabolic process (GO:0006563)2.75661042
94GDP-mannose metabolic process (GO:0019673)2.75383525
95peptidyl-arginine omega-N-methylation (GO:0035247)2.74412496
96deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.73901898
97negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.70892179
98mitochondrial fusion (GO:0008053)2.67646942
99ncRNA metabolic process (GO:0034660)2.66703799
100CTP metabolic process (GO:0046036)2.65546614

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.95781337
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.84527562
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.52881907
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51150575
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16643690
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.13947857
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94553778
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.92636692
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.83740986
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76300108
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69753325
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.69455729
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.60473856
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55822200
15XRN2_22483619_ChIP-Seq_HELA_Human2.50880750
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.40246451
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34359163
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31820627
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26171863
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21500163
21GABP_19822575_ChIP-Seq_HepG2_Human2.16072974
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13252527
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11782004
24DCP1A_22483619_ChIP-Seq_HELA_Human2.05017158
25* FOXP3_21729870_ChIP-Seq_TREG_Human2.04388347
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03698867
27TTF2_22483619_ChIP-Seq_HELA_Human2.00698256
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.97637089
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95964853
30CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.92224100
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89630662
32VDR_21846776_ChIP-Seq_THP-1_Human1.84693031
33VDR_23849224_ChIP-Seq_CD4+_Human1.83233671
34MYC_22102868_ChIP-Seq_BL_Human1.81465772
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.80063677
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77476979
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76861722
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76720563
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75361902
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69991488
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.69331377
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69252760
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65653482
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64477517
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56609584
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.56477811
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.54280297
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51499946
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51210517
50KDM5A_27292631_Chip-Seq_BREAST_Human1.48220406
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47261589
52CIITA_25753668_ChIP-Seq_RAJI_Human1.47207424
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45469544
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40927194
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38218161
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37722600
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36988335
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30312801
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29799335
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29587946
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28940195
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28647844
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28278310
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27649764
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25423252
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.25029144
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24099002
68ZNF263_19887448_ChIP-Seq_K562_Human1.23405328
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21354196
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21248517
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19875256
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19467765
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.16203333
74TFEB_21752829_ChIP-Seq_HELA_Human1.12959896
75* FOXP1_21924763_ChIP-Seq_HESCs_Human1.10995313
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10593473
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07817808
78CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07390527
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03481874
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03345146
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02996568
82ELK1_19687146_ChIP-ChIP_HELA_Human1.01279771
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.01022625
84MAF_26560356_Chip-Seq_TH2_Human1.00715876
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99732756
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98083187
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96943232
88ELK3_25401928_ChIP-Seq_HUVEC_Human0.96431136
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95594950
90ELF1_20517297_ChIP-Seq_JURKAT_Human0.94888212
91P68_20966046_ChIP-Seq_HELA_Human0.92923604
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.91815922
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90997416
94SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89629411
95SPI1_23547873_ChIP-Seq_NB4_Human0.89401609
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87621425
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86700645
98CTCF_26484167_Chip-Seq_Bcells_Mouse0.86395059
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85686016
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85686016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.09908488
2MP0006292_abnormal_olfactory_placode3.98980140
3MP0008058_abnormal_DNA_repair3.49659913
4MP0004957_abnormal_blastocyst_morpholog3.45953317
5MP0009379_abnormal_foot_pigmentation3.35914828
6MP0003111_abnormal_nucleus_morphology3.30587660
7MP0003077_abnormal_cell_cycle2.94729165
8MP0010094_abnormal_chromosome_stability2.82460056
9MP0010030_abnormal_orbit_morphology2.73703994
10MP0008932_abnormal_embryonic_tissue2.51068722
11MP0009333_abnormal_splenocyte_physiolog2.22578733
12MP0008260_abnormal_autophagy2.21593360
13MP0003186_abnormal_redox_activity2.07032139
14MP0008007_abnormal_cellular_replicative1.91057595
15MP0006035_abnormal_mitochondrial_morpho1.87986071
16MP0008789_abnormal_olfactory_epithelium1.87656849
17MP0001730_embryonic_growth_arrest1.85261244
18MP0000490_abnormal_crypts_of1.85082196
19MP0003806_abnormal_nucleotide_metabolis1.84584170
20MP0003786_premature_aging1.81149573
21MP0003718_maternal_effect1.75488298
22MP0003123_paternal_imprinting1.74204486
23MP0001293_anophthalmia1.73731526
24MP0008877_abnormal_DNA_methylation1.73253190
25MP0005499_abnormal_olfactory_system1.70948410
26MP0005394_taste/olfaction_phenotype1.70948410
27MP0000350_abnormal_cell_proliferation1.67829827
28MP0006036_abnormal_mitochondrial_physio1.65001278
29MP0005058_abnormal_lysosome_morphology1.59554230
30MP0002254_reproductive_system_inflammat1.58278001
31MP0000313_abnormal_cell_death1.56735170
32MP0000358_abnormal_cell_content/1.48848088
33MP0005380_embryogenesis_phenotype1.48045067
34MP0001672_abnormal_embryogenesis/_devel1.48045067
35MP0005501_abnormal_skin_physiology1.41558905
36MP0001697_abnormal_embryo_size1.40208318
37MP0002080_prenatal_lethality1.37803102
38MP0003315_abnormal_perineum_morphology1.35800514
39MP0000678_abnormal_parathyroid_gland1.34906626
40MP0002210_abnormal_sex_determination1.33731190
41MP0002132_abnormal_respiratory_system1.30689918
42MP0009053_abnormal_anal_canal1.30339874
43MP0003984_embryonic_growth_retardation1.29568242
44MP0001986_abnormal_taste_sensitivity1.28610417
45MP0002163_abnormal_gland_morphology1.24575505
46MP0009278_abnormal_bone_marrow1.23853133
47MP0002085_abnormal_embryonic_tissue1.22461438
48MP0002088_abnormal_embryonic_growth/wei1.21549211
49MP0002396_abnormal_hematopoietic_system1.21002190
50MP0003941_abnormal_skin_development1.19407497
51MP0009697_abnormal_copulation1.18739070
52MP0000049_abnormal_middle_ear1.18032296
53MP0002796_impaired_skin_barrier1.17965516
54MP0005075_abnormal_melanosome_morpholog1.17283129
55MP0008995_early_reproductive_senescence1.17041174
56MP0002019_abnormal_tumor_incidence1.14023513
57MP0001145_abnormal_male_reproductive1.13555742
58MP0003567_abnormal_fetal_cardiomyocyte1.12196916
59MP0002160_abnormal_reproductive_system1.11398052
60MP0005451_abnormal_body_composition1.09143605
61MP0001929_abnormal_gametogenesis1.07136377
62MP0005083_abnormal_biliary_tract1.06898090
63MP0000750_abnormal_muscle_regeneration1.06509421
64MP0004185_abnormal_adipocyte_glucose1.01937837
65MP0008057_abnormal_DNA_replication0.99798802
66MP0009672_abnormal_birth_weight0.98340024
67MP0000653_abnormal_sex_gland0.96395861
68MP0001764_abnormal_homeostasis0.95760994
69MP0005377_hearing/vestibular/ear_phenot0.93837531
70MP0003878_abnormal_ear_physiology0.93837531
71MP0000703_abnormal_thymus_morphology0.92689957
72MP0002653_abnormal_ependyma_morphology0.92251411
73MP0002249_abnormal_larynx_morphology0.91907052
74MP0002398_abnormal_bone_marrow0.90859293
75MP0002722_abnormal_immune_system0.88739011
76MP0000689_abnormal_spleen_morphology0.86863664
77MP0002938_white_spotting0.86255828
78MP0002084_abnormal_developmental_patter0.85884363
79MP0001849_ear_inflammation0.84145199
80MP0002429_abnormal_blood_cell0.84128244
81MP0009840_abnormal_foam_cell0.82463544
82MP0001119_abnormal_female_reproductive0.78256963
83MP0005670_abnormal_white_adipose0.77683175
84MP0002086_abnormal_extraembryonic_tissu0.77569446
85MP0001545_abnormal_hematopoietic_system0.77186720
86MP0005397_hematopoietic_system_phenotyp0.77186720
87MP0002111_abnormal_tail_morphology0.73752539
88MP0005384_cellular_phenotype0.72300734
89MP0002697_abnormal_eye_size0.70934589
90MP0004197_abnormal_fetal_growth/weight/0.69571381
91MP0005367_renal/urinary_system_phenotyp0.68626501
92MP0000516_abnormal_urinary_system0.68626501
93MP0001188_hyperpigmentation0.68614191
94MP0002092_abnormal_eye_morphology0.68493814
95MP0010307_abnormal_tumor_latency0.68263853
96MP0005084_abnormal_gallbladder_morpholo0.65877493
97MP0003698_abnormal_male_reproductive0.65479127
98MP0000716_abnormal_immune_system0.64947022
99MP0004264_abnormal_extraembryonic_tissu0.64754965
100MP0001529_abnormal_vocalization0.63743018

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.41751873
2Abnormality of cells of the erythroid lineage (HP:0012130)4.52805439
3Abnormal number of erythroid precursors (HP:0012131)4.25830466
4Aplasia/Hypoplasia of the sacrum (HP:0008517)4.24907870
5Microvesicular hepatic steatosis (HP:0001414)4.08303393
6Macrocytic anemia (HP:0001972)3.45185298
7Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.35312101
8Abnormal mitochondria in muscle tissue (HP:0008316)3.22675400
9Multiple enchondromatosis (HP:0005701)3.17380302
10Acute necrotizing encephalopathy (HP:0006965)3.15724493
11Microretrognathia (HP:0000308)3.14215610
12Mitochondrial inheritance (HP:0001427)3.12288881
13Pallor (HP:0000980)3.11029313
14Increased hepatocellular lipid droplets (HP:0006565)3.06352261
15Increased CSF lactate (HP:0002490)3.05584330
16Respiratory difficulties (HP:0002880)2.95946296
17Hepatocellular necrosis (HP:0001404)2.93709763
18Acute encephalopathy (HP:0006846)2.93657026
19Progressive muscle weakness (HP:0003323)2.91391277
20Decreased activity of mitochondrial respiratory chain (HP:0008972)2.89469785
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.89469785
22Increased intramyocellular lipid droplets (HP:0012240)2.89237294
23Aplastic anemia (HP:0001915)2.80594705
24Progressive external ophthalmoplegia (HP:0000590)2.76993615
25Lipid accumulation in hepatocytes (HP:0006561)2.73680774
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.72087285
27Type I transferrin isoform profile (HP:0003642)2.68251625
28Cleft eyelid (HP:0000625)2.65379967
29Increased serum lactate (HP:0002151)2.64813514
30Horseshoe kidney (HP:0000085)2.63516541
31Abnormal umbilical cord blood vessels (HP:0011403)2.60885819
32Single umbilical artery (HP:0001195)2.60885819
33Abnormality of the fetal cardiovascular system (HP:0010948)2.60885819
34Testicular atrophy (HP:0000029)2.60282292
35Broad distal phalanx of finger (HP:0009836)2.55678173
36Increased muscle lipid content (HP:0009058)2.54539520
37Reduced antithrombin III activity (HP:0001976)2.51834826
38Facial cleft (HP:0002006)2.51412623
39Hepatic necrosis (HP:0002605)2.49139471
40Lactic acidosis (HP:0003128)2.44985597
41Colon cancer (HP:0003003)2.40338288
42Exercise intolerance (HP:0003546)2.36577739
43Renal Fanconi syndrome (HP:0001994)2.35303644
44Abnormality of reticulocytes (HP:0004312)2.32183871
45Vaginal fistula (HP:0004320)2.30913875
46Thrombocytosis (HP:0001894)2.30429877
47Absent thumb (HP:0009777)2.30062660
48Trismus (HP:0000211)2.27897701
49Poikiloderma (HP:0001029)2.27691644
50Ragged-red muscle fibers (HP:0003200)2.26923320
51Cerebral hypomyelination (HP:0006808)2.21741997
52Progressive macrocephaly (HP:0004481)2.19981086
53Premature ovarian failure (HP:0008209)2.19640606
54Short middle phalanx of the 5th finger (HP:0004220)2.19352122
55Abnormality of the umbilical cord (HP:0010881)2.18089462
56Cholecystitis (HP:0001082)2.17627662
57Abnormal gallbladder physiology (HP:0012438)2.17627662
58Abnormal lung lobation (HP:0002101)2.16958691
59Facial hemangioma (HP:0000329)2.16182783
60Rectovaginal fistula (HP:0000143)2.16115314
61Rectal fistula (HP:0100590)2.16115314
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13510892
63Abnormal protein glycosylation (HP:0012346)2.11772435
64Abnormal glycosylation (HP:0012345)2.11772435
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11772435
66Abnormal protein N-linked glycosylation (HP:0012347)2.11772435
67Triphalangeal thumb (HP:0001199)2.10705498
68Birth length less than 3rd percentile (HP:0003561)2.08347978
69Carpal bone hypoplasia (HP:0001498)2.06553583
70Cerebral edema (HP:0002181)2.05951316
713-Methylglutaconic aciduria (HP:0003535)1.99129348
72Rough bone trabeculation (HP:0100670)1.97738495
73Squamous cell carcinoma (HP:0002860)1.96237941
74Absent radius (HP:0003974)1.91649823
75Stenosis of the external auditory canal (HP:0000402)1.90082650
76Abnormality of the preputium (HP:0100587)1.89088339
77Deep palmar crease (HP:0006191)1.88903902
78Chromsome breakage (HP:0040012)1.88608071
79Agammaglobulinemia (HP:0004432)1.87946944
80Ectopic kidney (HP:0000086)1.81007591
81Abnormalities of placenta or umbilical cord (HP:0001194)1.80136188
82Patent foramen ovale (HP:0001655)1.79407781
83Intestinal fistula (HP:0100819)1.77998884
84Capillary hemangiomas (HP:0005306)1.73680020
85Death in infancy (HP:0001522)1.73062156
86Pancytopenia (HP:0001876)1.72598555
87Basal cell carcinoma (HP:0002671)1.72538537
88Absent forearm bone (HP:0003953)1.72146122
89Aplasia involving forearm bones (HP:0009822)1.72146122
90Meckel diverticulum (HP:0002245)1.71720529
91Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.71165807
92Exertional dyspnea (HP:0002875)1.69092878
93Hyperglycinemia (HP:0002154)1.68098190
94Petechiae (HP:0000967)1.67656159
95Hypoplastic pelvis (HP:0008839)1.65885654
96Oligodactyly (HP:0012165)1.64674801
97Partial duplication of thumb phalanx (HP:0009944)1.64473973
98Choanal stenosis (HP:0000452)1.62941453
99Upper motor neuron abnormality (HP:0002127)1.61944543
100Absent rod-and cone-mediated responses on ERG (HP:0007688)1.61012755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.39336028
2CDK194.27410339
3BUB14.19669194
4STK163.94244303
5VRK23.75137856
6TESK22.60844195
7PBK2.54876541
8CDC72.41520738
9SMG12.20135047
10ARAF2.11338845
11SRPK12.06238741
12BCKDK1.97059342
13PIM21.83152857
14PASK1.74861194
15BRAF1.59148319
16DYRK31.52252413
17TAOK21.51892238
18TTK1.48422735
19LRRK21.43737662
20PDK21.37098993
21PRPF4B1.31188693
22NUAK11.27326517
23AURKA1.26200374
24IRAK31.24847897
25ERN11.24840451
26CHEK21.24721461
27CDK71.23977716
28PLK41.23268449
29VRK11.21647694
30MAP4K11.20941019
31MAP3K81.19343005
32PLK11.18734656
33MAP2K31.14264741
34BMX1.12936383
35TAF11.12686788
36TRIM281.12223012
37MAP3K101.08279862
38ATR0.96554148
39STK40.94537415
40NME10.87745150
41AURKB0.87505762
42MAP3K110.87369006
43CDK40.83620899
44KDR0.82068620
45CHEK10.80727238
46PAK40.79328747
47NEK20.78796073
48MST40.77953259
49PAK10.77080112
50DYRK20.76310642
51RPS6KB20.76307093
52ABL20.75451479
53ZAK0.74738882
54ILK0.73826393
55TESK10.73028186
56PRKCI0.72478356
57BRSK10.72027045
58FLT30.70675218
59NEK10.68782581
60MUSK0.68328808
61IRAK40.65609413
62IKBKB0.64796330
63PLK30.63943535
64PIM10.62971765
65RAF10.61475877
66GRK60.60425024
67CSNK2A20.60163617
68RPS6KA40.58844109
69CSNK2A10.57731871
70DAPK30.56780937
71RPS6KA50.56653847
72STK100.55924650
73TNK20.55680312
74TRIB30.50685093
75MATK0.50626584
76DAPK10.49656924
77SIK30.49293839
78CLK10.48526113
79IRAK20.48348565
80SIK10.47720695
81WEE10.47689352
82RPS6KC10.45343868
83RPS6KL10.45343868
84CDK20.44901946
85MKNK10.44457264
86CDK80.42547935
87EIF2AK20.41872972
88CSF1R0.38342611
89MAP3K30.37173377
90RPS6KA10.36768906
91TAOK10.36566644
92AKT20.36280469
93ATM0.34548548
94MAP2K20.34234037
95CDK11A0.33487539
96TBK10.32909278
97MARK30.30238972
98RPS6KA60.30159027
99CDK10.30074848
100EIF2AK30.29210091

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.67582802
2DNA replication_Homo sapiens_hsa030303.80844984
3Base excision repair_Homo sapiens_hsa034103.36330548
4Mismatch repair_Homo sapiens_hsa034303.16333823
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10470913
6Proteasome_Homo sapiens_hsa030503.03720654
7RNA polymerase_Homo sapiens_hsa030202.89446325
8Spliceosome_Homo sapiens_hsa030402.53129571
9Sulfur relay system_Homo sapiens_hsa041222.39791528
10RNA transport_Homo sapiens_hsa030132.33383684
11Pyrimidine metabolism_Homo sapiens_hsa002402.28193223
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18233904
13Homologous recombination_Homo sapiens_hsa034402.17777287
14Oxidative phosphorylation_Homo sapiens_hsa001902.07359693
15Parkinsons disease_Homo sapiens_hsa050122.06064526
16Nucleotide excision repair_Homo sapiens_hsa034201.79238945
17Non-homologous end-joining_Homo sapiens_hsa034501.74420817
18Huntingtons disease_Homo sapiens_hsa050161.70814837
19Cell cycle_Homo sapiens_hsa041101.67656225
20Fanconi anemia pathway_Homo sapiens_hsa034601.58014131
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.56951862
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51107964
23Biosynthesis of amino acids_Homo sapiens_hsa012301.49472380
24One carbon pool by folate_Homo sapiens_hsa006701.48708592
25RNA degradation_Homo sapiens_hsa030181.48461672
26mRNA surveillance pathway_Homo sapiens_hsa030151.39551566
27Pentose phosphate pathway_Homo sapiens_hsa000301.38435929
28Folate biosynthesis_Homo sapiens_hsa007901.34896874
29Basal transcription factors_Homo sapiens_hsa030221.29020799
30Purine metabolism_Homo sapiens_hsa002301.23486659
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23467198
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19177088
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18631065
34Carbon metabolism_Homo sapiens_hsa012001.18009026
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17953353
36p53 signaling pathway_Homo sapiens_hsa041151.11616098
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11361957
38Fatty acid elongation_Homo sapiens_hsa000621.10348291
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09065093
40Glutathione metabolism_Homo sapiens_hsa004801.00319334
41Alzheimers disease_Homo sapiens_hsa050100.93594656
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92107798
43Galactose metabolism_Homo sapiens_hsa000520.89544627
44Pyruvate metabolism_Homo sapiens_hsa006200.89457217
45Epstein-Barr virus infection_Homo sapiens_hsa051690.88370566
46Fructose and mannose metabolism_Homo sapiens_hsa000510.84644413
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84614557
48Protein export_Homo sapiens_hsa030600.83451087
49Primary immunodeficiency_Homo sapiens_hsa053400.83376108
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81170710
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79973318
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77864233
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73811741
54Regulation of autophagy_Homo sapiens_hsa041400.70771360
55N-Glycan biosynthesis_Homo sapiens_hsa005100.67042870
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65644209
57Steroid biosynthesis_Homo sapiens_hsa001000.63668236
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62332051
59Herpes simplex infection_Homo sapiens_hsa051680.60706744
60Metabolic pathways_Homo sapiens_hsa011000.60656531
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.56697267
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52264937
63Selenocompound metabolism_Homo sapiens_hsa004500.50310559
64Shigellosis_Homo sapiens_hsa051310.49676197
65HTLV-I infection_Homo sapiens_hsa051660.49255385
66Acute myeloid leukemia_Homo sapiens_hsa052210.45952571
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.45151632
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43585695
69Viral carcinogenesis_Homo sapiens_hsa052030.43100735
70Bladder cancer_Homo sapiens_hsa052190.39434370
71Basal cell carcinoma_Homo sapiens_hsa052170.39100340
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38897344
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37118951
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35961032
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34255389
76Thyroid cancer_Homo sapiens_hsa052160.33644915
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32680956
78Oocyte meiosis_Homo sapiens_hsa041140.31499641
79Systemic lupus erythematosus_Homo sapiens_hsa053220.28662396
80Colorectal cancer_Homo sapiens_hsa052100.28323937
81Other glycan degradation_Homo sapiens_hsa005110.27634171
82Apoptosis_Homo sapiens_hsa042100.26686004
83Vitamin digestion and absorption_Homo sapiens_hsa049770.24813433
84Legionellosis_Homo sapiens_hsa051340.24646206
85Asthma_Homo sapiens_hsa053100.21569491
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21173069
87Wnt signaling pathway_Homo sapiens_hsa043100.20642260
88Notch signaling pathway_Homo sapiens_hsa043300.20488237
89B cell receptor signaling pathway_Homo sapiens_hsa046620.19001178
90Hepatitis B_Homo sapiens_hsa051610.17795969
91Hedgehog signaling pathway_Homo sapiens_hsa043400.17258139
92Propanoate metabolism_Homo sapiens_hsa006400.17116623
93Viral myocarditis_Homo sapiens_hsa054160.15979757
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.15662739
95Arginine and proline metabolism_Homo sapiens_hsa003300.15073771
96Vibrio cholerae infection_Homo sapiens_hsa051100.14747897
97Antigen processing and presentation_Homo sapiens_hsa046120.11640989
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11563796
99Allograft rejection_Homo sapiens_hsa053300.10716219
100Cardiac muscle contraction_Homo sapiens_hsa042600.10336849

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