ZNF582

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zing finger protein and putative transcription factor that is highly methylated in cervical cancers. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA integration (GO:0015074)4.13927867
2synapsis (GO:0007129)3.91221650
3hypothalamus development (GO:0021854)3.78678545
4platelet dense granule organization (GO:0060155)3.70709048
5protein neddylation (GO:0045116)3.68326727
6piRNA metabolic process (GO:0034587)3.61340155
7tongue development (GO:0043586)3.52738761
8olfactory bulb development (GO:0021772)3.44297397
9tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.40717078
10RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.40717078
11ribosomal small subunit assembly (GO:0000028)3.39761257
12nonmotile primary cilium assembly (GO:0035058)3.37865851
13peroxisome fission (GO:0016559)3.36919433
14regulation of development, heterochronic (GO:0040034)3.35413436
15pyrimidine nucleobase catabolic process (GO:0006208)3.32664275
16intraciliary transport (GO:0042073)3.29182077
17microtubule depolymerization (GO:0007019)3.28905498
18chemosensory behavior (GO:0007635)3.27208817
19cullin deneddylation (GO:0010388)3.26178418
20positive regulation of mitochondrial fission (GO:0090141)3.20695064
21seminiferous tubule development (GO:0072520)3.19484313
22regulation of timing of cell differentiation (GO:0048505)3.19384473
23positive regulation of male gonad development (GO:2000020)3.18512473
24protein deneddylation (GO:0000338)3.17754639
25forebrain neuron differentiation (GO:0021879)3.17558052
26pituitary gland development (GO:0021983)3.16404373
27regulation of male gonad development (GO:2000018)3.13070348
28resolution of meiotic recombination intermediates (GO:0000712)3.12693266
29retinal ganglion cell axon guidance (GO:0031290)3.11378986
30head development (GO:0060322)3.09797096
31negative regulation of cardiac muscle tissue growth (GO:0055022)3.08677305
32negative regulation of heart growth (GO:0061117)3.08677305
33somite development (GO:0061053)3.04931217
34dorsal/ventral axis specification (GO:0009950)3.03573938
35regulation of feeding behavior (GO:0060259)2.96285756
36regulation of helicase activity (GO:0051095)2.94592368
37reciprocal DNA recombination (GO:0035825)2.93372005
38reciprocal meiotic recombination (GO:0007131)2.93372005
39neural tube formation (GO:0001841)2.93084274
40male meiosis I (GO:0007141)2.92308118
41biotin metabolic process (GO:0006768)2.86080677
42negative regulation of amino acid transport (GO:0051956)2.86001972
43NADH dehydrogenase complex assembly (GO:0010257)2.85306182
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85306182
45mitochondrial respiratory chain complex I assembly (GO:0032981)2.85306182
46fatty acid elongation (GO:0030497)2.83761220
47negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.82993874
48negative regulation of translation, ncRNA-mediated (GO:0040033)2.82993874
49regulation of translation, ncRNA-mediated (GO:0045974)2.82993874
50response to pheromone (GO:0019236)2.81529209
51preassembly of GPI anchor in ER membrane (GO:0016254)2.78500956
52mRNA splice site selection (GO:0006376)2.75601178
53DNA methylation involved in gamete generation (GO:0043046)2.75449794
54positive regulation of growth hormone secretion (GO:0060124)2.75245029
55positive regulation of oligodendrocyte differentiation (GO:0048714)2.73877139
56histone H2A acetylation (GO:0043968)2.72877368
57limb bud formation (GO:0060174)2.70395271
58cell proliferation in forebrain (GO:0021846)2.69753239
59ubiquinone biosynthetic process (GO:0006744)2.68850275
60regulation of glutamate secretion (GO:0014048)2.68774484
61histone H2A ubiquitination (GO:0033522)2.68744433
62regulation of growth hormone secretion (GO:0060123)2.67243382
63DNA demethylation (GO:0080111)2.66959946
64chaperone-mediated protein transport (GO:0072321)2.66198317
65cerebral cortex radially oriented cell migration (GO:0021799)2.65889986
66anterograde synaptic vesicle transport (GO:0048490)2.64158171
67ubiquinone metabolic process (GO:0006743)2.63331108
68positive regulation of amino acid transport (GO:0051957)2.62721282
69protein complex biogenesis (GO:0070271)2.61554995
70valine metabolic process (GO:0006573)2.59876949
71negative regulation of metanephros development (GO:0072217)2.58085036
72negative regulation of DNA recombination (GO:0045910)2.58030294
73regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.58011489
74coenzyme catabolic process (GO:0009109)2.55095308
75protein localization to cilium (GO:0061512)2.54393631
76protein polyglutamylation (GO:0018095)2.53300773
77histone H2A monoubiquitination (GO:0035518)2.51918288
78meiosis I (GO:0007127)2.51453083
79negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.49476756
80single strand break repair (GO:0000012)2.48541796
81nucleobase catabolic process (GO:0046113)2.48382785
82protein-cofactor linkage (GO:0018065)2.48204760
83presynaptic membrane assembly (GO:0097105)2.47031555
84negative regulation of telomere maintenance (GO:0032205)2.46688685
85C-terminal protein lipidation (GO:0006501)2.45670013
86regulation of sarcomere organization (GO:0060297)2.45436667
87negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.45056969
88negative regulation of cardiac muscle tissue development (GO:0055026)2.44592456
89oxidative demethylation (GO:0070989)2.44277018
90auditory receptor cell differentiation (GO:0042491)2.42579034
91detection of light stimulus involved in visual perception (GO:0050908)2.42058409
92detection of light stimulus involved in sensory perception (GO:0050962)2.42058409
93spinal cord association neuron differentiation (GO:0021527)2.38834639
94mesenchymal to epithelial transition (GO:0060231)2.38526566
95hindbrain development (GO:0030902)2.38206437
96presynaptic membrane organization (GO:0097090)2.37363952
97DNA damage response, detection of DNA damage (GO:0042769)2.36876617
98transmission of nerve impulse (GO:0019226)2.36514594
99protein localization to synapse (GO:0035418)2.35920147
100C-terminal protein amino acid modification (GO:0018410)2.35724868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.08180968
2IGF1R_20145208_ChIP-Seq_DFB_Human3.78329916
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30900207
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.17956429
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.14958113
6EZH2_22144423_ChIP-Seq_EOC_Human3.07287556
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.95447136
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74412886
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59860886
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.46932109
11PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33930134
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.23379197
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18392106
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15795539
15TAF15_26573619_Chip-Seq_HEK293_Human2.15291904
16ELK1_19687146_ChIP-ChIP_HELA_Human2.06069263
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.04641672
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04620760
19IRF1_19129219_ChIP-ChIP_H3396_Human2.03570788
20FUS_26573619_Chip-Seq_HEK293_Human1.99362200
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88431060
22VDR_23849224_ChIP-Seq_CD4+_Human1.87598284
23EWS_26573619_Chip-Seq_HEK293_Human1.85949884
24VDR_22108803_ChIP-Seq_LS180_Human1.84044221
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83500076
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83319338
27RNF2_27304074_Chip-Seq_NSC_Mouse1.83046007
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82043778
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70676984
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69464333
31MYC_18940864_ChIP-ChIP_HL60_Human1.67961636
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67050245
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.66536343
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.66015057
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65877010
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61227710
37P300_19829295_ChIP-Seq_ESCs_Human1.56782148
38* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52296052
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.49978700
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49528256
41GABP_19822575_ChIP-Seq_HepG2_Human1.47668987
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46272248
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46272248
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46050029
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.45147583
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44237729
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41181379
48GBX2_23144817_ChIP-Seq_PC3_Human1.39356237
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38656907
50* FOXP3_21729870_ChIP-Seq_TREG_Human1.38186531
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33951653
52TP53_22573176_ChIP-Seq_HFKS_Human1.29636511
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28036788
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27609321
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27434242
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26478889
57CBP_20019798_ChIP-Seq_JUKART_Human1.25375997
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25375997
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24881108
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24205132
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22462907
62TTF2_22483619_ChIP-Seq_HELA_Human1.20662319
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19010303
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17934967
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16151685
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15076352
67SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12986144
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12754939
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12116790
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07534298
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.07515879
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.07382821
73RUNX2_22187159_ChIP-Seq_PCA_Human1.06821955
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06595983
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05936401
76DCP1A_22483619_ChIP-Seq_HELA_Human1.02513186
77MYC_18555785_ChIP-Seq_MESCs_Mouse1.02046781
78SOX2_19829295_ChIP-Seq_ESCs_Human1.00905844
79NANOG_19829295_ChIP-Seq_ESCs_Human1.00905844
80ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99365134
81KDM5A_27292631_Chip-Seq_BREAST_Human0.99246259
82ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98196342
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96304708
84E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94889833
85PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94714482
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92968625
87TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92094864
88AR_25329375_ChIP-Seq_VCAP_Human0.91951710
89SMAD4_21799915_ChIP-Seq_A2780_Human0.91918489
90NCOR_22424771_ChIP-Seq_293T_Human0.91603623
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91347307
92MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90853574
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90011818
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89995686
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89084160
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.89030648
97REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88296195
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87480612
99POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87292409
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86337810

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.25234879
2MP0008877_abnormal_DNA_methylation4.13645274
3MP0002822_catalepsy3.24878852
4MP0001529_abnormal_vocalization3.18541977
5MP0002102_abnormal_ear_morphology2.94147476
6MP0008995_early_reproductive_senescence2.80606712
7MP0003122_maternal_imprinting2.74289074
8MP0003787_abnormal_imprinting2.53941966
9MP0003121_genomic_imprinting2.29474522
10MP0003567_abnormal_fetal_cardiomyocyte2.27049271
11MP0008789_abnormal_olfactory_epithelium2.25211110
12MP0003195_calcinosis2.20564582
13MP0002653_abnormal_ependyma_morphology2.01356085
14MP0003123_paternal_imprinting1.99702383
15MP0001293_anophthalmia1.97408740
16MP0003880_abnormal_central_pattern1.94439373
17MP0005499_abnormal_olfactory_system1.91631707
18MP0005394_taste/olfaction_phenotype1.91631707
19MP0002234_abnormal_pharynx_morphology1.88988583
20MP0002638_abnormal_pupillary_reflex1.81550821
21MP0003938_abnormal_ear_development1.77700550
22MP0006072_abnormal_retinal_apoptosis1.77288811
23MP0004133_heterotaxia1.64433586
24MP0003786_premature_aging1.61665693
25MP0002938_white_spotting1.60648601
26MP0005367_renal/urinary_system_phenotyp1.55360454
27MP0000516_abnormal_urinary_system1.55360454
28MP0005253_abnormal_eye_physiology1.54645077
29MP0000372_irregular_coat_pigmentation1.53031596
30MP0001286_abnormal_eye_development1.52647880
31MP0002233_abnormal_nose_morphology1.51570354
32MP0000631_abnormal_neuroendocrine_gland1.51369413
33MP0006276_abnormal_autonomic_nervous1.50846273
34MP0000049_abnormal_middle_ear1.49448447
35MP0000778_abnormal_nervous_system1.48767646
36MP0002736_abnormal_nociception_after1.47717620
37MP0003718_maternal_effect1.40706148
38MP0003890_abnormal_embryonic-extraembry1.34868978
39MP0002837_dystrophic_cardiac_calcinosis1.33860108
40MP0008058_abnormal_DNA_repair1.30332509
41MP0002210_abnormal_sex_determination1.27482580
42MP0003755_abnormal_palate_morphology1.24952741
43MP0004142_abnormal_muscle_tone1.23663845
44MP0005248_abnormal_Harderian_gland1.21677572
45MP0003119_abnormal_digestive_system1.20473669
46MP0005391_vision/eye_phenotype1.19795885
47MP0003937_abnormal_limbs/digits/tail_de1.17826504
48MP0003221_abnormal_cardiomyocyte_apopto1.17476185
49MP0001929_abnormal_gametogenesis1.16663222
50MP0002132_abnormal_respiratory_system1.12010761
51MP0006035_abnormal_mitochondrial_morpho1.11709985
52MP0001145_abnormal_male_reproductive1.11398287
53MP0009697_abnormal_copulation1.11349202
54MP0000653_abnormal_sex_gland1.10207589
55MP0002751_abnormal_autonomic_nervous1.09186278
56MP0005551_abnormal_eye_electrophysiolog1.04475027
57MP0005195_abnormal_posterior_eye1.04430284
58MP0003698_abnormal_male_reproductive0.99646022
59MP0000537_abnormal_urethra_morphology0.97904657
60MP0002295_abnormal_pulmonary_circulatio0.97451557
61MP0004215_abnormal_myocardial_fiber0.96125201
62MP0006036_abnormal_mitochondrial_physio0.94367556
63MP0003861_abnormal_nervous_system0.93389973
64MP0002090_abnormal_vision0.91439040
65MP0005171_absent_coat_pigmentation0.90193624
66MP0003283_abnormal_digestive_organ0.90150824
67MP0002752_abnormal_somatic_nervous0.89628705
68MP0002092_abnormal_eye_morphology0.89276638
69MP0004811_abnormal_neuron_physiology0.88528879
70MP0002127_abnormal_cardiovascular_syste0.88354289
71MP0000955_abnormal_spinal_cord0.87504566
72MP0002184_abnormal_innervation0.86841976
73MP0002084_abnormal_developmental_patter0.86085913
74MP0002095_abnormal_skin_pigmentation0.85067721
75MP0001764_abnormal_homeostasis0.84905610
76MP0001968_abnormal_touch/_nociception0.81645165
77MP0002152_abnormal_brain_morphology0.81447000
78MP0001919_abnormal_reproductive_system0.80667053
79MP0002697_abnormal_eye_size0.78882666
80MP0004924_abnormal_behavior0.77387427
81MP0005386_behavior/neurological_phenoty0.77387427
82MP0005075_abnormal_melanosome_morpholog0.76344114
83MP0002254_reproductive_system_inflammat0.75222074
84MP0000428_abnormal_craniofacial_morphol0.74964181
85MP0003011_delayed_dark_adaptation0.73109154
86MP0003942_abnormal_urinary_system0.71948736
87MP0003136_yellow_coat_color0.71901828
88MP0001119_abnormal_female_reproductive0.71199161
89MP0005084_abnormal_gallbladder_morpholo0.70598721
90MP0002277_abnormal_respiratory_mucosa0.70053249
91MP0005389_reproductive_system_phenotype0.70042972
92MP0002116_abnormal_craniofacial_bone0.69950850
93MP0001324_abnormal_eye_pigmentation0.69309739
94MP0002557_abnormal_social/conspecific_i0.68133232
95MP0002882_abnormal_neuron_morphology0.67619722
96MP0001984_abnormal_olfaction0.66429309
97MP0000026_abnormal_inner_ear0.64337607
98MP0003186_abnormal_redox_activity0.63215248
99MP0002735_abnormal_chemical_nociception0.63196941
100MP0001727_abnormal_embryo_implantation0.63138362

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)3.80936681
2Congenital primary aphakia (HP:0007707)3.73608726
3Gait imbalance (HP:0002141)3.70471961
4Nephrogenic diabetes insipidus (HP:0009806)3.68056485
5Intestinal atresia (HP:0011100)3.55673250
6True hermaphroditism (HP:0010459)3.46669196
7Hyperglycinemia (HP:0002154)3.33333640
8Adrenal hypoplasia (HP:0000835)3.26918436
9Gonadal dysgenesis (HP:0000133)3.21908508
10Vaginal atresia (HP:0000148)3.13729340
11Genital tract atresia (HP:0001827)3.10380308
12Male pseudohermaphroditism (HP:0000037)2.99278174
13Poor coordination (HP:0002370)2.92729950
14Abnormal sex determination (HP:0012244)2.92266702
15Sex reversal (HP:0012245)2.92266702
16Dry hair (HP:0011359)2.90136913
17Abnormal number of incisors (HP:0011064)2.86217559
18Median cleft lip (HP:0000161)2.80937712
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.70656799
20Degeneration of the lateral corticospinal tracts (HP:0002314)2.70656799
21Oligodactyly (hands) (HP:0001180)2.67352692
22Abnormality of the metopic suture (HP:0005556)2.66421904
23Tubulointerstitial nephritis (HP:0001970)2.64420811
24Short tibia (HP:0005736)2.64192484
25Testicular neoplasm (HP:0010788)2.60281665
26Oligodactyly (HP:0012165)2.55998347
27Double outlet right ventricle (HP:0001719)2.46413896
28Congenital malformation of the right heart (HP:0011723)2.46413896
29Shoulder girdle muscle weakness (HP:0003547)2.45469312
30Colon cancer (HP:0003003)2.43039291
31Pancreatic fibrosis (HP:0100732)2.39793750
32Decreased testicular size (HP:0008734)2.35599590
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.35294894
34Prominent metopic ridge (HP:0005487)2.33087768
35Pancreatic cysts (HP:0001737)2.25205315
36Hypoglycemic coma (HP:0001325)2.25180682
37Renal cortical cysts (HP:0000803)2.24505388
38Tachypnea (HP:0002789)2.22433641
39Abnormal hair whorl (HP:0010721)2.20263737
40Gonadotropin excess (HP:0000837)2.20194934
41Growth hormone deficiency (HP:0000824)2.16005665
42Postaxial hand polydactyly (HP:0001162)2.14617313
43Hypoglycemic seizures (HP:0002173)2.11986672
44Abnormality of the corticospinal tract (HP:0002492)2.08809937
45Specific learning disability (HP:0001328)2.06940227
46Abnormality of midbrain morphology (HP:0002418)2.05963950
47Molar tooth sign on MRI (HP:0002419)2.05963950
48Abnormality of the anterior horn cell (HP:0006802)2.05138879
49Degeneration of anterior horn cells (HP:0002398)2.05138879
50Acute encephalopathy (HP:0006846)2.04788238
51Postaxial foot polydactyly (HP:0001830)2.04447939
52Preaxial hand polydactyly (HP:0001177)2.03792584
53Abnormality of the labia minora (HP:0012880)2.01938454
54Polyphagia (HP:0002591)2.00420480
55Abnormality of the hip-girdle musculature (HP:0001445)1.99292808
56Abnormality of the musculature of the pelvis (HP:0001469)1.99292808
57Broad foot (HP:0001769)1.99214648
58Hyperglycinuria (HP:0003108)1.97064369
59Abnormality of the incisor (HP:0000676)1.95233202
603-Methylglutaconic aciduria (HP:0003535)1.94048801
61Anophthalmia (HP:0000528)1.94027879
62Impaired vibration sensation in the lower limbs (HP:0002166)1.93265133
63Type 2 muscle fiber atrophy (HP:0003554)1.93234273
64Abnormality of serine family amino acid metabolism (HP:0010894)1.92812023
65Abnormality of glycine metabolism (HP:0010895)1.92812023
66Anomalous pulmonary venous return (HP:0010772)1.92306184
67Abnormality of the parathyroid morphology (HP:0011766)1.91553550
68Nephronophthisis (HP:0000090)1.91479639
69Disproportionate short-trunk short stature (HP:0003521)1.91236952
70Renal hypoplasia (HP:0000089)1.87506680
71Progressive inability to walk (HP:0002505)1.86498058
72Hyperinsulinemic hypoglycemia (HP:0000825)1.85987466
73Hemivertebrae (HP:0002937)1.84081640
74Hip dysplasia (HP:0001385)1.82919737
75Atrophy/Degeneration involving motor neurons (HP:0007373)1.80879179
76Gastrointestinal atresia (HP:0002589)1.80348414
77Thyroid-stimulating hormone excess (HP:0002925)1.79682044
78Nephroblastoma (Wilms tumor) (HP:0002667)1.79129944
79Abnormal lung lobation (HP:0002101)1.76788414
80Septo-optic dysplasia (HP:0100842)1.76774372
81Acute necrotizing encephalopathy (HP:0006965)1.76524876
82Increased CSF lactate (HP:0002490)1.75333501
83Methylmalonic acidemia (HP:0002912)1.75007406
84Micropenis (HP:0000054)1.74859012
85Diaphragmatic weakness (HP:0009113)1.73676931
86Female pseudohermaphroditism (HP:0010458)1.73307699
87Muscle fiber atrophy (HP:0100295)1.73031456
88Chorioretinal atrophy (HP:0000533)1.72584588
89Hepatic necrosis (HP:0002605)1.70939589
90Microvesicular hepatic steatosis (HP:0001414)1.70878286
91Pancreatic islet-cell hyperplasia (HP:0004510)1.70495583
92Abnormality of endocrine pancreas physiology (HP:0012093)1.68161018
93Abnormality of the pancreatic islet cells (HP:0006476)1.68161018
94Embryonal renal neoplasm (HP:0011794)1.67295669
95Triphalangeal thumb (HP:0001199)1.67261896
96Stridor (HP:0010307)1.66210250
97Aplasia/Hypoplasia of the lens (HP:0008063)1.65884214
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65744412
99Drooling (HP:0002307)1.65614491
100Supernumerary spleens (HP:0009799)1.65471678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.83432318
2WNK33.60085120
3SRPK13.19638876
4PAK32.70841392
5TRIM282.66527116
6BCR2.30265591
7MAP3K42.10928109
8STK162.06414689
9MKNK22.05645066
10MKNK12.04382571
11ADRBK22.04132037
12FRK2.02531620
13MAP2K71.86359621
14STK38L1.84871534
15CASK1.83152509
16SIK31.82587990
17CDK191.75219686
18PASK1.73840437
19DYRK21.67278547
20PLK21.62329208
21EPHB21.61863171
22MAPK131.61490505
23GRK11.57279180
24CSNK1G21.56600658
25NUAK11.51797275
26CSNK1G11.48141560
27CSNK1G31.45639658
28BMPR1B1.42088939
29PLK31.40902104
30CDC71.38948654
31PINK11.36678844
32ACVR1B1.29611299
33CSNK1A1L1.29085711
34TNIK1.26413747
35MARK11.26392992
36TXK1.17954928
37VRK11.15688037
38INSRR1.14592100
39DYRK31.14451758
40TAOK11.13306514
41STK241.10182383
42EPHA40.98123634
43PRKCG0.95917241
44CAMKK20.92598569
45KSR10.90402832
46DYRK1A0.86876009
47TNK20.85853811
48MINK10.82683506
49AKT30.82522595
50DYRK1B0.81599957
51MUSK0.79679741
52CAMK1D0.75061714
53CDK30.74611722
54STK110.72182963
55NLK0.71255883
56PLK10.70411519
57NEK90.70270468
58STK30.69363885
59RPS6KA40.68115977
60ERBB30.66582233
61FLT30.65717925
62MARK20.63873210
63CAMK40.63181603
64UHMK10.62588785
65STK40.60141462
66CAMK1G0.59107067
67VRK20.58615661
68TSSK60.52808314
69SGK20.51880444
70FER0.51763217
71MST40.50789279
72CSNK1E0.50470229
73PDK20.49117184
74ATM0.48211682
75MAP3K70.47373791
76PKN20.46755815
77CSNK1A10.46519751
78BCKDK0.46268418
79CDK140.45685069
80SGK2230.45163995
81SGK4940.45163995
82SCYL20.44595486
83PRKAA10.43706842
84CHEK10.42462283
85ZAK0.42096002
86PRKACA0.41908186
87NTRK30.41082994
88CDK50.39617972
89MAP2K40.39594716
90CAMK10.38699061
91PRKCE0.38469605
92ATR0.37778498
93CSNK2A10.36983863
94PKN10.35720786
95CDK180.35418927
96TGFBR10.34583925
97PRKACG0.33621474
98PLK40.33389110
99CDK20.33093120
100CSNK1D0.33031492

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.50579312
2Fatty acid elongation_Homo sapiens_hsa000622.95923226
3Protein export_Homo sapiens_hsa030602.77645954
4Basal transcription factors_Homo sapiens_hsa030222.74046058
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71254053
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51244457
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.49146020
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.38762385
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25882603
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.14161776
11Regulation of autophagy_Homo sapiens_hsa041401.99872684
12Homologous recombination_Homo sapiens_hsa034401.97170653
13Butanoate metabolism_Homo sapiens_hsa006501.96676341
14Ribosome_Homo sapiens_hsa030101.86572818
15Steroid biosynthesis_Homo sapiens_hsa001001.84058396
16Oxidative phosphorylation_Homo sapiens_hsa001901.81852583
17Mismatch repair_Homo sapiens_hsa034301.79743531
18Hedgehog signaling pathway_Homo sapiens_hsa043401.73116687
19beta-Alanine metabolism_Homo sapiens_hsa004101.59773081
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59661640
21Parkinsons disease_Homo sapiens_hsa050121.58101408
22Spliceosome_Homo sapiens_hsa030401.56151892
23Nucleotide excision repair_Homo sapiens_hsa034201.52880065
24Vitamin B6 metabolism_Homo sapiens_hsa007501.52473255
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.49495649
26RNA polymerase_Homo sapiens_hsa030201.48600021
27Basal cell carcinoma_Homo sapiens_hsa052171.48088232
28RNA degradation_Homo sapiens_hsa030181.47732984
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.47730050
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43108368
31RNA transport_Homo sapiens_hsa030131.40691636
32Non-homologous end-joining_Homo sapiens_hsa034501.37315102
33Collecting duct acid secretion_Homo sapiens_hsa049661.37129172
34Peroxisome_Homo sapiens_hsa041461.36283990
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36044459
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35848721
37Fanconi anemia pathway_Homo sapiens_hsa034601.35187463
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32655210
39Phototransduction_Homo sapiens_hsa047441.30886105
40Pyruvate metabolism_Homo sapiens_hsa006201.24403349
41Nitrogen metabolism_Homo sapiens_hsa009101.18102795
42Fatty acid metabolism_Homo sapiens_hsa012121.17222430
43Selenocompound metabolism_Homo sapiens_hsa004501.15245586
44Huntingtons disease_Homo sapiens_hsa050161.13297650
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.10605134
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10155926
47Base excision repair_Homo sapiens_hsa034101.08153259
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05843722
49Taste transduction_Homo sapiens_hsa047421.04616070
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91559868
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88599805
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88482348
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82736954
54Wnt signaling pathway_Homo sapiens_hsa043100.80846201
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80470557
56Oocyte meiosis_Homo sapiens_hsa041140.79856220
57mRNA surveillance pathway_Homo sapiens_hsa030150.79378748
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78216721
59Circadian rhythm_Homo sapiens_hsa047100.77606150
60Pyrimidine metabolism_Homo sapiens_hsa002400.76999520
61Purine metabolism_Homo sapiens_hsa002300.75421293
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74742499
63Arginine and proline metabolism_Homo sapiens_hsa003300.73446981
64Cell cycle_Homo sapiens_hsa041100.72295813
65Tryptophan metabolism_Homo sapiens_hsa003800.71783801
66p53 signaling pathway_Homo sapiens_hsa041150.68684039
67Linoleic acid metabolism_Homo sapiens_hsa005910.66969339
68Metabolic pathways_Homo sapiens_hsa011000.65760513
69Notch signaling pathway_Homo sapiens_hsa043300.65341016
70Fatty acid degradation_Homo sapiens_hsa000710.62251726
71Morphine addiction_Homo sapiens_hsa050320.60102038
72One carbon pool by folate_Homo sapiens_hsa006700.59342100
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57975097
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57286279
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55640608
76Carbon metabolism_Homo sapiens_hsa012000.55477064
77Ovarian steroidogenesis_Homo sapiens_hsa049130.55403742
78Proteasome_Homo sapiens_hsa030500.55223875
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54595792
80Insulin secretion_Homo sapiens_hsa049110.54113975
81Glutathione metabolism_Homo sapiens_hsa004800.53693755
82Hippo signaling pathway_Homo sapiens_hsa043900.48016953
83Olfactory transduction_Homo sapiens_hsa047400.47159333
84Cardiac muscle contraction_Homo sapiens_hsa042600.46584337
85DNA replication_Homo sapiens_hsa030300.46496576
86Alzheimers disease_Homo sapiens_hsa050100.45039926
87Caffeine metabolism_Homo sapiens_hsa002320.44875126
88Ether lipid metabolism_Homo sapiens_hsa005650.43629952
89Lysine degradation_Homo sapiens_hsa003100.43431379
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43265661
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42013573
92Axon guidance_Homo sapiens_hsa043600.41859202
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40215736
94Fat digestion and absorption_Homo sapiens_hsa049750.39723033
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34431136
96Arachidonic acid metabolism_Homo sapiens_hsa005900.34417607
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.33681830
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32994440
99Nicotine addiction_Homo sapiens_hsa050330.32571712
100Glucagon signaling pathway_Homo sapiens_hsa049220.30246016

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