ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.28675899
2	kidney morphogenesis (GO:0060993)	4.27679357
3	DNA deamination (GO:0045006)	4.18720759
4	pyrimidine nucleobase catabolic process (GO:0006208)	4.06765056
5	negative regulation of telomere maintenance (GO:0032205)	3.94849532
6	urinary tract smooth muscle contraction (GO:0014848)	3.93336755
7	atrial cardiac muscle cell action potential (GO:0086014)	3.84697948
8	postsynaptic membrane organization (GO:0001941)	3.83709427
9	L-fucose catabolic process (GO:0042355)	3.77814266
10	fucose catabolic process (GO:0019317)	3.77814266
11	L-fucose metabolic process (GO:0042354)	3.77814266
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.75921086
13	presynaptic membrane assembly (GO:0097105)	3.70292501
14	pseudouridine synthesis (GO:0001522)	3.42589718
15	protein-cofactor linkage (GO:0018065)	3.41396447
16	nucleobase catabolic process (GO:0046113)	3.40122175
17	detection of light stimulus involved in visual perception (GO:0050908)	3.37973203
18	detection of light stimulus involved in sensory perception (GO:0050962)	3.37973203
19	piRNA metabolic process (GO:0034587)	3.28166317
20	nonmotile primary cilium assembly (GO:0035058)	3.25978471
21	neuron cell-cell adhesion (GO:0007158)	3.24895476
22	regulation of microtubule-based movement (GO:0060632)	3.22447566
23	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.17470767
24	presynaptic membrane organization (GO:0097090)	3.15957941
25	neural tube formation (GO:0001841)	3.12822169
26	peristalsis (GO:0030432)	3.12600720
27	protein polyglutamylation (GO:0018095)	3.12561308
28	water-soluble vitamin biosynthetic process (GO:0042364)	3.09948650
29	protein localization to cilium (GO:0061512)	3.09376300
30	cornea development in camera-type eye (GO:0061303)	3.08094780
31	gamma-aminobutyric acid transport (GO:0015812)	3.04360955
32	response to pheromone (GO:0019236)	3.03515708
33	preassembly of GPI anchor in ER membrane (GO:0016254)	2.99570389
34	regulation of telomere maintenance (GO:0032204)	2.98918807
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.96130084
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.96130084
37	NADH dehydrogenase complex assembly (GO:0010257)	2.96130084
38	regulation of respiratory system process (GO:0044065)	2.94033704
39	epithelial cilium movement (GO:0003351)	2.89303692
40	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.87932498
41	adult feeding behavior (GO:0008343)	2.85991345
42	regulation of action potential (GO:0098900)	2.85846721
43	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.84937860
44	regulation of cilium movement (GO:0003352)	2.82924887
45	cellular ketone body metabolic process (GO:0046950)	2.82336961
46	head development (GO:0060322)	2.81062731
47	negative regulation of systemic arterial blood pressure (GO:0003085)	2.81049931
48	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.78832021
49	positive regulation of action potential (GO:0045760)	2.76789620
50	protein complex biogenesis (GO:0070271)	2.76402390
51	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.75728595
52	positive regulation of mitochondrial fission (GO:0090141)	2.75215733
53	vocalization behavior (GO:0071625)	2.73848964
54	platelet dense granule organization (GO:0060155)	2.72388399
55	cilium morphogenesis (GO:0060271)	2.70135981
56	regulation of glucokinase activity (GO:0033131)	2.69281435
57	regulation of hexokinase activity (GO:1903299)	2.69281435
58	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.68721370
59	indole-containing compound catabolic process (GO:0042436)	2.62543966
60	indolalkylamine catabolic process (GO:0046218)	2.62543966
61	tryptophan catabolic process (GO:0006569)	2.62543966
62	glycosphingolipid biosynthetic process (GO:0006688)	2.62471203
63	neuronal action potential (GO:0019228)	2.62108109
64	axoneme assembly (GO:0035082)	2.61068579
65	indolalkylamine metabolic process (GO:0006586)	2.59699594
66	synapse assembly (GO:0007416)	2.58485669
67	DNA demethylation (GO:0080111)	2.58405700
68	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.57659001
69	mitochondrial respiratory chain complex assembly (GO:0033108)	2.57440529
70	auditory behavior (GO:0031223)	2.57297263
71	kynurenine metabolic process (GO:0070189)	2.56879199
72	phasic smooth muscle contraction (GO:0014821)	2.56832101
73	ubiquinone biosynthetic process (GO:0006744)	2.56819236
74	protein localization to synapse (GO:0035418)	2.55751508
75	somite development (GO:0061053)	2.55747794
76	behavioral response to ethanol (GO:0048149)	2.55258284
77	negative regulation of organelle assembly (GO:1902116)	2.55138781
78	regulation of mesoderm development (GO:2000380)	2.54685437
79	arginine catabolic process (GO:0006527)	2.54260061
80	C4-dicarboxylate transport (GO:0015740)	2.53958782
81	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.53754380
82	ubiquinone metabolic process (GO:0006743)	2.52874857
83	synaptic transmission, cholinergic (GO:0007271)	2.51289028
84	ketone body metabolic process (GO:1902224)	2.50974334
85	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.50901158
86	cilium organization (GO:0044782)	2.50890263
87	negative regulation of mast cell activation (GO:0033004)	2.50613525
88	limb bud formation (GO:0060174)	2.50220232
89	positive regulation of guanylate cyclase activity (GO:0031284)	2.49284657
90	GPI anchor metabolic process (GO:0006505)	2.47946341
91	L-methionine salvage (GO:0071267)	2.47825923
92	L-methionine biosynthetic process (GO:0071265)	2.47825923
93	amino acid salvage (GO:0043102)	2.47825923
94	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.47583177
95	glycerophospholipid catabolic process (GO:0046475)	2.47434897
96	primary amino compound metabolic process (GO:1901160)	2.46453281
97	cilium assembly (GO:0042384)	2.45825983
98	neurotransmitter-gated ion channel clustering (GO:0072578)	2.45560833
99	sulfation (GO:0051923)	2.45403142
100	anterograde axon cargo transport (GO:0008089)	2.43864498

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.28838066
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.38445758
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.29879471
4	VDR_22108803_ChIP-Seq_LS180_Human	2.93647565
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.78867449
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.72965995
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.55939063
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.45403003
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.39508063
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.27568625
11	FUS_26573619_Chip-Seq_HEK293_Human	2.26363053
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.26178210
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.07628808
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.04127816
15	P300_19829295_ChIP-Seq_ESCs_Human	2.03035969
16	EWS_26573619_Chip-Seq_HEK293_Human	2.00397676
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.98193341
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.84312366
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83804518
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.81288098
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.79500517
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.73125679
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.72129731
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.71079545
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.65578282
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63873028
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60722617
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.60500363
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.58724192
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.58358072
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.57781407
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.57411173
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56573412
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55001368
35	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.54142844
36	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.52610562
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51933775
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50168466
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.50168466
40	AR_25329375_ChIP-Seq_VCAP_Human	1.50020584
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.48497338
42	STAT3_23295773_ChIP-Seq_U87_Human	1.48164784
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.47480261
44	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.45946010
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.43976517
46	TCF4_23295773_ChIP-Seq_U87_Human	1.43331101
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43273358
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.43273358
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42544111
50	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.42500833
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40941048
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40458457
53	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39088536
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36538749
55	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.29133546
56	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.28995691
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.26915011
58	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25556679
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25492887
60	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25237317
61	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.24544263
62	AR_21572438_ChIP-Seq_LNCaP_Human	1.24307513
63	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24158437
64	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.24083981
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23658744
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23658744
67	MYC_18940864_ChIP-ChIP_HL60_Human	1.22907742
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21497606
69	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.21482125
70	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19253558
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18493867
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18099976
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16901731
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16901731
75	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16046111
76	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15430381
77	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.12236611
78	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11759257
79	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.10723199
80	NCOR_22424771_ChIP-Seq_293T_Human	1.10722313
81	* EST1_17652178_ChIP-ChIP_JURKAT_Human	1.08982667
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08892992
83	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.08246071
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07378752
85	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06904610
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06154530
87	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.05180308
88	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05106480
89	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04596474
90	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03494309
91	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.02402500
92	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01820902
93	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01502502
94	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99698485
95	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99480339
96	AR_20517297_ChIP-Seq_VCAP_Human	0.99471384
97	MYC_19829295_ChIP-Seq_ESCs_Human	0.98707435
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98702969
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97955684
100	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97642141

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	3.76509887
2	MP0002102_abnormal_ear_morphology	3.69552133
3	MP0008877_abnormal_DNA_methylation	2.84971725
4	MP0002735_abnormal_chemical_nociception	2.71539129
5	MP0003787_abnormal_imprinting	2.41899294
6	MP0001968_abnormal_touch/_nociception	2.40643977
7	MP0001529_abnormal_vocalization	2.34542086
8	MP0003880_abnormal_central_pattern	2.27296775
9	MP0005167_abnormal_blood-brain_barrier	2.23104685
10	MP0005551_abnormal_eye_electrophysiolog	2.21175800
11	MP0003646_muscle_fatigue	2.13574439
12	MP0009046_muscle_twitch	2.12263143
13	MP0009745_abnormal_behavioral_response	2.09396045
14	MP0002736_abnormal_nociception_after	2.08516212
15	MP0002837_dystrophic_cardiac_calcinosis	2.02406316
16	MP0003195_calcinosis	2.01705277
17	MP0008872_abnormal_physiological_respon	1.98421496
18	MP0000569_abnormal_digit_pigmentation	1.93064528
19	MP0005645_abnormal_hypothalamus_physiol	1.89214633
20	MP0001984_abnormal_olfaction	1.85098949
21	MP0002822_catalepsy	1.80132991
22	MP0002272_abnormal_nervous_system	1.78799183
23	MP0002638_abnormal_pupillary_reflex	1.77725555
24	MP0004043_abnormal_pH_regulation	1.75230952
25	MP0006292_abnormal_olfactory_placode	1.73813550
26	MP0006276_abnormal_autonomic_nervous	1.71789623
27	MP0005253_abnormal_eye_physiology	1.71132027
28	MP0005386_behavior/neurological_phenoty	1.68943563
29	MP0004924_abnormal_behavior	1.68943563
30	MP0006072_abnormal_retinal_apoptosis	1.68861096
31	MP0001486_abnormal_startle_reflex	1.67473682
32	MP0004133_heterotaxia	1.65323021
33	MP0001970_abnormal_pain_threshold	1.62285204
34	MP0002572_abnormal_emotion/affect_behav	1.61301803
35	MP0002734_abnormal_mechanical_nocicepti	1.59840169
36	MP0004142_abnormal_muscle_tone	1.57272719
37	MP0004885_abnormal_endolymph	1.57088484
38	MP0003635_abnormal_synaptic_transmissio	1.55352618
39	MP0002733_abnormal_thermal_nociception	1.53392256
40	MP0002064_seizures	1.53074715
41	MP0003122_maternal_imprinting	1.50412977
42	MP0003011_delayed_dark_adaptation	1.49913157
43	MP0002063_abnormal_learning/memory/cond	1.48954390
44	MP0002557_abnormal_social/conspecific_i	1.42189754
45	MP0001501_abnormal_sleep_pattern	1.41552500
46	MP0002653_abnormal_ependyma_morphology	1.41282678
47	MP0001986_abnormal_taste_sensitivity	1.40919004
48	MP0000778_abnormal_nervous_system	1.37093615
49	MP0005646_abnormal_pituitary_gland	1.36029655
50	MP0002067_abnormal_sensory_capabilities	1.34980666
51	MP0004742_abnormal_vestibular_system	1.32938715
52	MP0003137_abnormal_impulse_conducting	1.29386950
53	MP0000427_abnormal_hair_cycle	1.27095400
54	MP0008875_abnormal_xenobiotic_pharmacok	1.26861193
55	MP0003121_genomic_imprinting	1.25546617
56	MP0001905_abnormal_dopamine_level	1.21758017
57	MP0005084_abnormal_gallbladder_morpholo	1.19529143
58	MP0001485_abnormal_pinna_reflex	1.18236262
59	MP0003718_maternal_effect	1.17895432
60	MP0002234_abnormal_pharynx_morphology	1.16766763
61	MP0002938_white_spotting	1.16337043
62	MP0002876_abnormal_thyroid_physiology	1.15321918
63	MP0003890_abnormal_embryonic-extraembry	1.13975336
64	MP0004215_abnormal_myocardial_fiber	1.10542505
65	MP0004859_abnormal_synaptic_plasticity	1.10327978
66	MP0000383_abnormal_hair_follicle	1.02309554
67	MP0002751_abnormal_autonomic_nervous	1.02279880
68	MP0008775_abnormal_heart_ventricle	1.00423273
69	MP0000631_abnormal_neuroendocrine_gland	0.98851138
70	MP0002184_abnormal_innervation	0.96315736
71	MP0002277_abnormal_respiratory_mucosa	0.95893697
72	MP0005195_abnormal_posterior_eye	0.95026845
73	MP0003136_yellow_coat_color	0.94293485
74	MP0008058_abnormal_DNA_repair	0.94090557
75	MP0000230_abnormal_systemic_arterial	0.93253031
76	MP0004145_abnormal_muscle_electrophysio	0.92696394
77	MP0002752_abnormal_somatic_nervous	0.90816034
78	MP0004085_abnormal_heartbeat	0.88126162
79	MP0003119_abnormal_digestive_system	0.85969116
80	MP0000372_irregular_coat_pigmentation	0.84630079
81	MP0000026_abnormal_inner_ear	0.84461952
82	MP0010386_abnormal_urinary_bladder	0.82971273
83	MP0005389_reproductive_system_phenotype	0.82140829
84	MP0001440_abnormal_grooming_behavior	0.79830877
85	MP0004270_analgesia	0.79142845
86	MP0002160_abnormal_reproductive_system	0.79060740
87	MP0002882_abnormal_neuron_morphology	0.78404531
88	MP0005423_abnormal_somatic_nervous	0.78010289
89	MP0002909_abnormal_adrenal_gland	0.76859794
90	MP0002229_neurodegeneration	0.75892398
91	MP0001348_abnormal_lacrimal_gland	0.75537909
92	MP0003633_abnormal_nervous_system	0.74625612
93	MP0001963_abnormal_hearing_physiology	0.73742267
94	MP0001919_abnormal_reproductive_system	0.73395624
95	MP0005391_vision/eye_phenotype	0.72692018
96	MP0005448_abnormal_energy_balance	0.72404616
97	MP0008789_abnormal_olfactory_epithelium	0.72159222
98	MP0000955_abnormal_spinal_cord	0.71907742
99	MP0003698_abnormal_male_reproductive	0.70567514
100	MP0000049_abnormal_middle_ear	0.70471000

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Birth length less than 3rd percentile (HP:0003561)	5.00479642
2	Pancreatic cysts (HP:0001737)	4.29540386
3	Hyperventilation (HP:0002883)	4.02612327
4	Abnormality of midbrain morphology (HP:0002418)	3.95631769
5	Molar tooth sign on MRI (HP:0002419)	3.95631769
6	Congenital stationary night blindness (HP:0007642)	3.93407266
7	Pancreatic fibrosis (HP:0100732)	3.93096662
8	True hermaphroditism (HP:0010459)	3.91992226
9	Type II lissencephaly (HP:0007260)	3.66555397
10	Nephronophthisis (HP:0000090)	3.53468671
11	Medial flaring of the eyebrow (HP:0010747)	3.19281081
12	Lissencephaly (HP:0001339)	3.15516056
13	Abnormality of the renal cortex (HP:0011035)	3.13693555
14	Inability to walk (HP:0002540)	3.12950057
15	Gait imbalance (HP:0002141)	3.08897747
16	Abnormality of the renal medulla (HP:0100957)	3.08608705
17	Breast hypoplasia (HP:0003187)	2.85611962
18	Congenital primary aphakia (HP:0007707)	2.80976668
19	Abolished electroretinogram (ERG) (HP:0000550)	2.75138541
20	Broad-based gait (HP:0002136)	2.70785268
21	Progressive inability to walk (HP:0002505)	2.70668257
22	Patellar aplasia (HP:0006443)	2.70519456
23	Aplasia/Hypoplasia of the patella (HP:0006498)	2.56977003
24	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.56905881
25	Nephrogenic diabetes insipidus (HP:0009806)	2.54155275
26	Protruding tongue (HP:0010808)	2.52847011
27	Pendular nystagmus (HP:0012043)	2.52670551
28	Cystic liver disease (HP:0006706)	2.48718679
29	Pachygyria (HP:0001302)	2.48316715
30	Attenuation of retinal blood vessels (HP:0007843)	2.48032173
31	Microretrognathia (HP:0000308)	2.45263494
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.45141543
33	Retinal dysplasia (HP:0007973)	2.43126896
34	Chronic hepatic failure (HP:0100626)	2.41084581
35	Abnormality of the labia minora (HP:0012880)	2.40560588
36	Polyphagia (HP:0002591)	2.38749713
37	Renal cortical cysts (HP:0000803)	2.35688061
38	Progressive cerebellar ataxia (HP:0002073)	2.32583246
39	Genital tract atresia (HP:0001827)	2.25562631
40	Abnormality of alanine metabolism (HP:0010916)	2.23865965
41	Hyperalaninemia (HP:0003348)	2.23865965
42	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.23865965
43	Cerebellar dysplasia (HP:0007033)	2.23523536
44	Tubular atrophy (HP:0000092)	2.23438552
45	Myokymia (HP:0002411)	2.23288506
46	Limb dystonia (HP:0002451)	2.17635646
47	Scrotal hypoplasia (HP:0000046)	2.17357101
48	Vaginal atresia (HP:0000148)	2.16180324
49	Chorioretinal atrophy (HP:0000533)	2.14745072
50	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.13778840
51	Abnormal drinking behavior (HP:0030082)	2.13585564
52	Polydipsia (HP:0001959)	2.13585564
53	Genetic anticipation (HP:0003743)	2.13036153
54	Hemiparesis (HP:0001269)	2.12369935
55	Drooling (HP:0002307)	2.08169497
56	Bile duct proliferation (HP:0001408)	2.07800896
57	Abnormal biliary tract physiology (HP:0012439)	2.07800896
58	Mitochondrial inheritance (HP:0001427)	2.07358807
59	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.04352721
60	Abnormal respiratory motile cilium morphology (HP:0005938)	2.04287078
61	Abnormal respiratory epithelium morphology (HP:0012253)	2.04287078
62	Keratoconus (HP:0000563)	2.03945742
63	Increased corneal curvature (HP:0100692)	2.03945742
64	Large for gestational age (HP:0001520)	2.03718171
65	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.03130704
66	Acute necrotizing encephalopathy (HP:0006965)	2.01175663
67	Sclerocornea (HP:0000647)	2.00912414
68	Absent speech (HP:0001344)	1.97965841
69	Widely spaced teeth (HP:0000687)	1.97016282
70	Optic nerve hypoplasia (HP:0000609)	1.96965159
71	Methylmalonic acidemia (HP:0002912)	1.96495065
72	Increased CSF lactate (HP:0002490)	1.95860883
73	Methylmalonic aciduria (HP:0012120)	1.94341465
74	Gaze-evoked nystagmus (HP:0000640)	1.93298055
75	Anencephaly (HP:0002323)	1.91883883
76	Congenital hepatic fibrosis (HP:0002612)	1.90176096
77	Poor speech (HP:0002465)	1.89962481
78	Abnormality of the pons (HP:0007361)	1.89904963
79	Poor coordination (HP:0002370)	1.89223943
80	Male pseudohermaphroditism (HP:0000037)	1.89005828
81	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88143838
82	Focal motor seizures (HP:0011153)	1.87732412
83	Optic disc pallor (HP:0000543)	1.86914711
84	Polyuria (HP:0000103)	1.86627356
85	Excessive salivation (HP:0003781)	1.85697235
86	Long foot (HP:0001833)	1.85549332
87	Stomach cancer (HP:0012126)	1.84480342
88	Lipid accumulation in hepatocytes (HP:0006561)	1.82727850
89	Postaxial foot polydactyly (HP:0001830)	1.79380591
90	3-Methylglutaconic aciduria (HP:0003535)	1.78385629
91	Increased hepatocellular lipid droplets (HP:0006565)	1.78070437
92	Colon cancer (HP:0003003)	1.77588271
93	Hypothermia (HP:0002045)	1.77164117
94	Congenital, generalized hypertrichosis (HP:0004540)	1.77161569
95	Severe muscular hypotonia (HP:0006829)	1.76857664
96	Furrowed tongue (HP:0000221)	1.76676485
97	Febrile seizures (HP:0002373)	1.76609887
98	Progressive macrocephaly (HP:0004481)	1.76476432
99	Epileptic encephalopathy (HP:0200134)	1.76420318
100	Narrow forehead (HP:0000341)	1.76006801

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	3.89772910
2	BMPR1B	3.88289075
3	FRK	3.74232806
4	CASK	3.63726594
5	DAPK2	3.00154936
6	ZAK	2.80781062
7	ADRBK2	2.78458283
8	WNK3	2.66201374
9	MAP4K2	2.56509139
10	MARK1	2.46789970
11	MAPK13	2.30945857
12	MAP3K4	2.19835467
13	PINK1	2.10338490
14	WNK4	1.96592687
15	GRK1	1.71644756
16	TGFBR1	1.69678896
17	MAP2K7	1.68221044
18	TLK1	1.63868906
19	TAOK3	1.63375858
20	INSRR	1.62235299
21	CAMKK2	1.58822047
22	TNIK	1.51477153
23	MKNK2	1.38395547
24	NUAK1	1.32472736
25	BCR	1.32066130
26	CAMKK1	1.29911575
27	NTRK2	1.29173784
28	NTRK3	1.28595664
29	BCKDK	1.26113869
30	SIK2	1.18718172
31	ADRBK1	1.16980508
32	DYRK2	1.16458139
33	TRIM28	1.12596342
34	TXK	1.11544963
35	STK38L	1.11256857
36	TIE1	1.07105017
37	CSNK1G2	1.04641081
38	PAK3	1.02313446
39	PRKCG	0.98781271
40	OXSR1	0.94477289
41	EPHA4	0.93723943
42	CSNK1G3	0.91240048
43	PHKG1	0.90287426
44	PHKG2	0.90287426
45	PNCK	0.89339315
46	NME1	0.87950599
47	PRKCE	0.87721138
48	CSNK1G1	0.85553186
49	STK39	0.84102145
50	CAMK2A	0.82422774
51	CSNK1A1L	0.76175052
52	ERBB3	0.74916313
53	DYRK3	0.72816600
54	PTK2B	0.68683573
55	MKNK1	0.68260675
56	RPS6KA5	0.62170575
57	MAP2K6	0.62149760
58	PLK2	0.61868281
59	CAMK4	0.59462974
60	VRK1	0.59321124
61	CAMK1	0.51362842
62	CSNK1A1	0.50615726
63	EPHB2	0.49888814
64	NEK2	0.49563339
65	PKN1	0.49312405
66	MAP2K4	0.49306519
67	MINK1	0.47957289
68	PRKACA	0.46156343
69	RPS6KA4	0.42440655
70	PRKCZ	0.40855764
71	GRK7	0.40844901
72	OBSCN	0.38304819
73	CDK3	0.36184171
74	PLK4	0.35329798
75	PRKCQ	0.34770515
76	PAK6	0.33724042
77	EPHA3	0.33723903
78	CAMK1D	0.33321329
79	DYRK1A	0.33174450
80	PLK3	0.32908145
81	TEC	0.32119232
82	CCNB1	0.31702934
83	CSNK1D	0.31555674
84	MAPK15	0.31297900
85	PRKAA1	0.30342424
86	SGK2	0.29090925
87	MAPKAPK5	0.28995796
88	PRKG1	0.28700116
89	FGFR2	0.28346101
90	PRKCA	0.27636082
91	PRKACB	0.27040505
92	SGK494	0.26426997
93	SGK223	0.26426997
94	MUSK	0.25995239
95	ATR	0.25168219
96	WEE1	0.24958598
97	CDK5	0.24532940
98	MAP2K1	0.24387521
99	CHUK	0.24218092
100	BRSK2	0.24089542

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.88235684
2	Nicotine addiction_Homo sapiens_hsa05033	2.84883147
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.78410035
4	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.50751122
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.37803100
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.37396954
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.33570371
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.33500881
9	Butanoate metabolism_Homo sapiens_hsa00650	2.32676705
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.19699726
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.14121581
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.01356521
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.99722839
14	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.97490209
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.79284058
16	GABAergic synapse_Homo sapiens_hsa04727	1.76455910
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.73243388
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.72231400
19	Basal transcription factors_Homo sapiens_hsa03022	1.69801054
20	Protein export_Homo sapiens_hsa03060	1.69359145
21	Parkinsons disease_Homo sapiens_hsa05012	1.65547079
22	Morphine addiction_Homo sapiens_hsa05032	1.62574749
23	Propanoate metabolism_Homo sapiens_hsa00640	1.56709268
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.54635189
25	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.47891693
26	Taste transduction_Homo sapiens_hsa04742	1.47506450
27	Circadian entrainment_Homo sapiens_hsa04713	1.45824284
28	ABC transporters_Homo sapiens_hsa02010	1.35666922
29	RNA polymerase_Homo sapiens_hsa03020	1.30555676
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.29203890
31	Glutamatergic synapse_Homo sapiens_hsa04724	1.28514151
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.27255100
33	Olfactory transduction_Homo sapiens_hsa04740	1.25234189
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.24934353
35	Serotonergic synapse_Homo sapiens_hsa04726	1.23878968
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.21120377
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.20720170
38	Insulin secretion_Homo sapiens_hsa04911	1.20175435
39	Steroid biosynthesis_Homo sapiens_hsa00100	1.17087145
40	Peroxisome_Homo sapiens_hsa04146	1.16684997
41	Alzheimers disease_Homo sapiens_hsa05010	1.16264961
42	Regulation of autophagy_Homo sapiens_hsa04140	1.13981622
43	Homologous recombination_Homo sapiens_hsa03440	1.13566227
44	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.12124098
45	RNA degradation_Homo sapiens_hsa03018	1.11018719
46	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.10155838
47	Caffeine metabolism_Homo sapiens_hsa00232	1.09098938
48	Huntingtons disease_Homo sapiens_hsa05016	1.08348794
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04404911
50	Collecting duct acid secretion_Homo sapiens_hsa04966	1.02970219
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.96070016
52	Dopaminergic synapse_Homo sapiens_hsa04728	0.93218814
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92631427
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.92189949
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89774588
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88410013
57	Amphetamine addiction_Homo sapiens_hsa05031	0.83840183
58	Salivary secretion_Homo sapiens_hsa04970	0.82429182
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.82015836
60	Calcium signaling pathway_Homo sapiens_hsa04020	0.79179177
61	Cocaine addiction_Homo sapiens_hsa05030	0.77671900
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77524691
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.71187272
64	Retinol metabolism_Homo sapiens_hsa00830	0.68685009
65	Sulfur relay system_Homo sapiens_hsa04122	0.68437458
66	Long-term depression_Homo sapiens_hsa04730	0.68375715
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66869596
68	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.65314466
69	Metabolic pathways_Homo sapiens_hsa01100	0.62167523
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61043269
71	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.59633502
72	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.58563342
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.58137531
74	Purine metabolism_Homo sapiens_hsa00230	0.56391660
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.56330066
76	Circadian rhythm_Homo sapiens_hsa04710	0.56150456
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.55273379
78	Axon guidance_Homo sapiens_hsa04360	0.53647883
79	Mineral absorption_Homo sapiens_hsa04978	0.51072549
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.51069735
81	Non-homologous end-joining_Homo sapiens_hsa03450	0.48677869
82	Cholinergic synapse_Homo sapiens_hsa04725	0.47826633
83	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.46294467
84	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.45434663
85	Fatty acid elongation_Homo sapiens_hsa00062	0.44928723
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.44134180
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.43310519
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41724444
89	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.39599748
90	Renin secretion_Homo sapiens_hsa04924	0.38583455
91	Pyrimidine metabolism_Homo sapiens_hsa00240	0.38379906
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37206099
93	One carbon pool by folate_Homo sapiens_hsa00670	0.36017356
94	Gastric acid secretion_Homo sapiens_hsa04971	0.35938037
95	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.34604663
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.34007418
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.33241729
98	Arginine and proline metabolism_Homo sapiens_hsa00330	0.32060429
99	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.31960490
100	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.31811337

ZNF583

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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