ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.22725947
2	neural tube formation (GO:0001841)	3.77334569
3	nonmotile primary cilium assembly (GO:0035058)	3.74512070
4	presynaptic membrane assembly (GO:0097105)	3.68996408
5	pyrimidine nucleobase catabolic process (GO:0006208)	3.68476445
6	gamma-aminobutyric acid transport (GO:0015812)	3.38045041
7	photoreceptor cell maintenance (GO:0045494)	3.37010302
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.31356071
9	intraciliary transport (GO:0042073)	3.23321649
10	retinal cone cell development (GO:0046549)	3.23146452
11	regulation of cilium movement (GO:0003352)	3.20350609
12	replication fork processing (GO:0031297)	3.18220894
13	epithelial cilium movement (GO:0003351)	3.17269484
14	reflex (GO:0060004)	3.15614244
15	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.15421590
16	regulation of translation, ncRNA-mediated (GO:0045974)	3.15421590
17	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.15421590
18	presynaptic membrane organization (GO:0097090)	3.14216056
19	cellular ketone body metabolic process (GO:0046950)	3.13157375
20	behavioral response to nicotine (GO:0035095)	3.12245352
21	tryptophan catabolic process (GO:0006569)	3.10326713
22	indole-containing compound catabolic process (GO:0042436)	3.10326713
23	indolalkylamine catabolic process (GO:0046218)	3.10326713
24	protein localization to cilium (GO:0061512)	3.07741111
25	cilium organization (GO:0044782)	3.05121055
26	neuron cell-cell adhesion (GO:0007158)	3.04388308
27	regulation of meiosis I (GO:0060631)	3.01698807
28	DNA double-strand break processing (GO:0000729)	3.01216160
29	kynurenine metabolic process (GO:0070189)	3.00225344
30	cilium assembly (GO:0042384)	2.99491411
31	nucleobase catabolic process (GO:0046113)	2.99232883
32	protein polyglutamylation (GO:0018095)	2.97775659
33	reciprocal meiotic recombination (GO:0007131)	2.94513556
34	reciprocal DNA recombination (GO:0035825)	2.94513556
35	inner ear receptor stereocilium organization (GO:0060122)	2.93707104
36	cilium morphogenesis (GO:0060271)	2.93635835
37	establishment of protein localization to Golgi (GO:0072600)	2.92475257
38	axoneme assembly (GO:0035082)	2.91593610
39	indolalkylamine metabolic process (GO:0006586)	2.90698433
40	cilium or flagellum-dependent cell motility (GO:0001539)	2.89500114
41	respiratory chain complex IV assembly (GO:0008535)	2.89040042
42	behavioral response to ethanol (GO:0048149)	2.88874407
43	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.88128963
44	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.85110053
45	cilium movement (GO:0003341)	2.82746818
46	protein complex biogenesis (GO:0070271)	2.81386030
47	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.80454372
48	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.79569325
49	postsynaptic membrane organization (GO:0001941)	2.78997677
50	C4-dicarboxylate transport (GO:0015740)	2.77358276
51	kidney morphogenesis (GO:0060993)	2.73987039
52	mitochondrial respiratory chain complex assembly (GO:0033108)	2.73143698
53	ketone body metabolic process (GO:1902224)	2.72874751
54	detection of light stimulus involved in sensory perception (GO:0050962)	2.72864256
55	detection of light stimulus involved in visual perception (GO:0050908)	2.72864256
56	fucose catabolic process (GO:0019317)	2.72854521
57	L-fucose metabolic process (GO:0042354)	2.72854521
58	L-fucose catabolic process (GO:0042355)	2.72854521
59	single strand break repair (GO:0000012)	2.72643190
60	DNA integration (GO:0015074)	2.72640857
61	glycosphingolipid biosynthetic process (GO:0006688)	2.71605918
62	centriole replication (GO:0007099)	2.70141663
63	limb bud formation (GO:0060174)	2.65925908
64	prenylation (GO:0097354)	2.61435251
65	protein prenylation (GO:0018342)	2.61435251
66	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.60858463
67	NADH dehydrogenase complex assembly (GO:0010257)	2.60858463
68	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.60858463
69	regulation of sarcomere organization (GO:0060297)	2.59673060
70	neuronal action potential (GO:0019228)	2.59525418
71	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.59057876
72	tryptophan metabolic process (GO:0006568)	2.58978102
73	amine catabolic process (GO:0009310)	2.55005517
74	cellular biogenic amine catabolic process (GO:0042402)	2.55005517
75	protein K11-linked deubiquitination (GO:0035871)	2.54994520
76	cytochrome complex assembly (GO:0017004)	2.53877053
77	protein targeting to Golgi (GO:0000042)	2.53709405
78	positive regulation of mitochondrial fission (GO:0090141)	2.53588388
79	heparin metabolic process (GO:0030202)	2.50689372
80	heparin biosynthetic process (GO:0030210)	2.50689372
81	neuronal action potential propagation (GO:0019227)	2.49285353
82	microtubule depolymerization (GO:0007019)	2.48722478
83	auditory receptor cell stereocilium organization (GO:0060088)	2.48683043
84	microtubule polymerization or depolymerization (GO:0031109)	2.46920493
85	cell wall macromolecule catabolic process (GO:0016998)	2.46816342
86	recombinational repair (GO:0000725)	2.44728970
87	double-strand break repair via homologous recombination (GO:0000724)	2.42696926
88	tachykinin receptor signaling pathway (GO:0007217)	2.42326518
89	righting reflex (GO:0060013)	2.42250153
90	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.40509366
91	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.39875908
92	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.39874207
93	regulation of mitotic spindle checkpoint (GO:1903504)	2.39874207
94	regulation of neurotransmitter uptake (GO:0051580)	2.39522564
95	regulation of development, heterochronic (GO:0040034)	2.38440314
96	piRNA metabolic process (GO:0034587)	2.38170487
97	cellular component assembly involved in morphogenesis (GO:0010927)	2.37964184
98	inositol phosphate catabolic process (GO:0071545)	2.37269493
99	negative regulation of telomere maintenance (GO:0032205)	2.36263906
100	positive regulation of developmental pigmentation (GO:0048087)	2.36092628

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.39409482
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.23816223
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.22127958
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.95164789
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.94945892
6	VDR_22108803_ChIP-Seq_LS180_Human	2.68172698
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.66795419
8	FUS_26573619_Chip-Seq_HEK293_Human	2.52362497
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.48319245
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.42777367
11	EWS_26573619_Chip-Seq_HEK293_Human	2.35740495
12	P300_19829295_ChIP-Seq_ESCs_Human	2.35052381
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.18378277
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.16912863
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.16611672
16	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.14992263
17	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.13491284
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10977175
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.10658257
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.03679889
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.89263233
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.87568493
23	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.83283222
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.81142083
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.79479051
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.77536884
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.76531549
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.75175941
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.70650034
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.69175751
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.68433576
32	STAT3_23295773_ChIP-Seq_U87_Human	1.67032609
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.66174933
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.64042176
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.64042176
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.63578619
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.63578619
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.60040071
39	TCF4_23295773_ChIP-Seq_U87_Human	1.57690744
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.56504953
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.55646246
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.52415975
43	AR_25329375_ChIP-Seq_VCAP_Human	1.50260389
44	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47745611
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47618026
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46188380
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.42784080
48	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.38900215
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38370609
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.36661356
51	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.34591064
52	BCAT_22108803_ChIP-Seq_LS180_Human	1.33917042
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33750826
54	AR_21572438_ChIP-Seq_LNCaP_Human	1.32505085
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.31386228
56	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.30263311
57	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.30174633
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29345363
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29345363
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28967069
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28949301
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28430777
63	REST_21632747_ChIP-Seq_MESCs_Mouse	1.28196493
64	IRF1_19129219_ChIP-ChIP_H3396_Human	1.26906231
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.24706990
66	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23432167
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.21574597
68	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.20904992
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20323253
70	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.20063114
71	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.19830857
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18053118
73	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17621313
74	P53_22387025_ChIP-Seq_ESCs_Mouse	1.16687704
75	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16025802
76	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15651129
77	* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12552960
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12512767
79	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.12215735
80	* FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12072841
81	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11828362
82	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.11714717
83	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.11138911
84	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.11134678
85	MYC_18940864_ChIP-ChIP_HL60_Human	1.10851321
86	* ELK1_19687146_ChIP-ChIP_HELA_Human	1.10512370
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08582901
88	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.07778646
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.05025874
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04262034
91	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.04249844
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03207481
93	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.02967075
94	JUN_21703547_ChIP-Seq_K562_Human	1.02829606
95	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.02610351
96	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01782878
97	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01782878
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01372417
99	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.00439029
100	KDM2B_26808549_Chip-Seq_REH_Human	1.00203153

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.20610339
2	MP0003880_abnormal_central_pattern	3.13723272
3	MP0008877_abnormal_DNA_methylation	2.77405790
4	MP0003787_abnormal_imprinting	2.67814084
5	MP0005645_abnormal_hypothalamus_physiol	2.51320382
6	MP0001968_abnormal_touch/_nociception	2.36472420
7	MP0002102_abnormal_ear_morphology	2.31920121
8	MP0009046_muscle_twitch	2.29291183
9	MP0001529_abnormal_vocalization	2.09916996
10	MP0002736_abnormal_nociception_after	2.09856591
11	MP0002837_dystrophic_cardiac_calcinosis	2.09589003
12	MP0001984_abnormal_olfaction	2.07527192
13	MP0006292_abnormal_olfactory_placode	2.03238038
14	MP0009745_abnormal_behavioral_response	1.97366695
15	MP0005551_abnormal_eye_electrophysiolog	1.96202710
16	MP0003195_calcinosis	1.94803097
17	MP0006276_abnormal_autonomic_nervous	1.92228027
18	MP0003121_genomic_imprinting	1.89494401
19	MP0006072_abnormal_retinal_apoptosis	1.86630581
20	MP0005253_abnormal_eye_physiology	1.83389108
21	MP0001486_abnormal_startle_reflex	1.82870582
22	MP0002735_abnormal_chemical_nociception	1.77374601
23	MP0002272_abnormal_nervous_system	1.70662902
24	MP0003122_maternal_imprinting	1.69596302
25	MP0002653_abnormal_ependyma_morphology	1.65131457
26	MP0008058_abnormal_DNA_repair	1.61267397
27	MP0002572_abnormal_emotion/affect_behav	1.59478717
28	MP0000631_abnormal_neuroendocrine_gland	1.57640700
29	MP0004142_abnormal_muscle_tone	1.53025886
30	MP0004147_increased_porphyrin_level	1.46943380
31	MP0002064_seizures	1.44026112
32	MP0008789_abnormal_olfactory_epithelium	1.43839684
33	MP0003136_yellow_coat_color	1.42770048
34	MP0003635_abnormal_synaptic_transmissio	1.42580788
35	MP0008995_early_reproductive_senescence	1.42381967
36	MP0005394_taste/olfaction_phenotype	1.39672877
37	MP0005499_abnormal_olfactory_system	1.39672877
38	MP0002063_abnormal_learning/memory/cond	1.39005408
39	MP0002557_abnormal_social/conspecific_i	1.35798368
40	MP0001501_abnormal_sleep_pattern	1.32254835
41	MP0001986_abnormal_taste_sensitivity	1.32141202
42	MP0000778_abnormal_nervous_system	1.30888986
43	MP0003718_maternal_effect	1.30711537
44	MP0009697_abnormal_copulation	1.28635358
45	MP0004270_analgesia	1.28523139
46	MP0003137_abnormal_impulse_conducting	1.27680028
47	MP0005084_abnormal_gallbladder_morpholo	1.26962934
48	MP0003890_abnormal_embryonic-extraembry	1.26492702
49	MP0002734_abnormal_mechanical_nocicepti	1.26428776
50	MP0002938_white_spotting	1.24547864
51	MP0002876_abnormal_thyroid_physiology	1.23769663
52	MP0000427_abnormal_hair_cycle	1.23108891
53	MP0004133_heterotaxia	1.22990676
54	MP0002638_abnormal_pupillary_reflex	1.22960448
55	MP0000372_irregular_coat_pigmentation	1.22801745
56	MP0002751_abnormal_autonomic_nervous	1.20856274
57	MP0001970_abnormal_pain_threshold	1.18943391
58	MP0002067_abnormal_sensory_capabilities	1.17600351
59	MP0003011_delayed_dark_adaptation	1.17169325
60	MP0002234_abnormal_pharynx_morphology	1.14841420
61	MP0004924_abnormal_behavior	1.14190622
62	MP0005386_behavior/neurological_phenoty	1.14190622
63	MP0002733_abnormal_thermal_nociception	1.12930113
64	MP0008057_abnormal_DNA_replication	1.12763843
65	MP0005646_abnormal_pituitary_gland	1.10401840
66	MP0004859_abnormal_synaptic_plasticity	1.09761599
67	MP0000516_abnormal_urinary_system	1.09230293
68	MP0005367_renal/urinary_system_phenotyp	1.09230293
69	MP0004043_abnormal_pH_regulation	1.07811274
70	MP0005187_abnormal_penis_morphology	1.02394152
71	MP0003698_abnormal_male_reproductive	1.02231085
72	MP0003646_muscle_fatigue	1.01664025
73	MP0005423_abnormal_somatic_nervous	0.99974138
74	MP0002184_abnormal_innervation	0.99558965
75	MP0002928_abnormal_bile_duct	0.98673272
76	MP0001905_abnormal_dopamine_level	0.98386993
77	MP0008872_abnormal_physiological_respon	0.98053037
78	MP0002752_abnormal_somatic_nervous	0.96234408
79	MP0001485_abnormal_pinna_reflex	0.95414820
80	MP0004145_abnormal_muscle_electrophysio	0.95284018
81	MP0002822_catalepsy	0.94963759
82	MP0001929_abnormal_gametogenesis	0.93715693
83	MP0003937_abnormal_limbs/digits/tail_de	0.93547772
84	MP0002095_abnormal_skin_pigmentation	0.92058599
85	MP0002882_abnormal_neuron_morphology	0.91514044
86	MP0005379_endocrine/exocrine_gland_phen	0.91209753
87	MP0004885_abnormal_endolymph	0.87735577
88	MP0000955_abnormal_spinal_cord	0.87685184
89	MP0005410_abnormal_fertilization	0.87190185
90	MP0004215_abnormal_myocardial_fiber	0.85758571
91	MP0005195_abnormal_posterior_eye	0.85658445
92	MP0002229_neurodegeneration	0.85450267
93	MP0002163_abnormal_gland_morphology	0.84893833
94	MP0002909_abnormal_adrenal_gland	0.83449618
95	MP0000026_abnormal_inner_ear	0.83420790
96	MP0005248_abnormal_Harderian_gland	0.83412315
97	MP0002233_abnormal_nose_morphology	0.81516520
98	MP0003119_abnormal_digestive_system	0.81488345
99	MP0004811_abnormal_neuron_physiology	0.81268485
100	MP0004742_abnormal_vestibular_system	0.80775698

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.93388276
2	Medial flaring of the eyebrow (HP:0010747)	3.67882415
3	Pancreatic fibrosis (HP:0100732)	3.64624081
4	Hyperventilation (HP:0002883)	3.48133267
5	True hermaphroditism (HP:0010459)	3.47933491
6	Gait imbalance (HP:0002141)	3.30788355
7	Molar tooth sign on MRI (HP:0002419)	3.28710963
8	Abnormality of midbrain morphology (HP:0002418)	3.28710963
9	Nephronophthisis (HP:0000090)	3.18454989
10	Congenital primary aphakia (HP:0007707)	3.18038733
11	Progressive inability to walk (HP:0002505)	3.03938928
12	Chronic hepatic failure (HP:0100626)	3.01760892
13	Intestinal atresia (HP:0011100)	2.95462091
14	Nephrogenic diabetes insipidus (HP:0009806)	2.92292043
15	Abnormality of the renal medulla (HP:0100957)	2.83208835
16	Abnormality of the renal cortex (HP:0011035)	2.80275170
17	Genital tract atresia (HP:0001827)	2.76119255
18	Inability to walk (HP:0002540)	2.75278590
19	Gaze-evoked nystagmus (HP:0000640)	2.71900725
20	Colon cancer (HP:0003003)	2.65109089
21	Vaginal atresia (HP:0000148)	2.61452179
22	Abnormality of the labia minora (HP:0012880)	2.59162161
23	Focal motor seizures (HP:0011153)	2.51949660
24	Absent speech (HP:0001344)	2.51173022
25	Progressive cerebellar ataxia (HP:0002073)	2.49860443
26	Abolished electroretinogram (ERG) (HP:0000550)	2.46072378
27	Renal cortical cysts (HP:0000803)	2.45638353
28	Broad-based gait (HP:0002136)	2.42528850
29	Drooling (HP:0002307)	2.35103471
30	Congenital stationary night blindness (HP:0007642)	2.35065584
31	Abnormal biliary tract physiology (HP:0012439)	2.34623104
32	Bile duct proliferation (HP:0001408)	2.34623104
33	Optic nerve hypoplasia (HP:0000609)	2.32455624
34	Poor coordination (HP:0002370)	2.29879091
35	Attenuation of retinal blood vessels (HP:0007843)	2.28671386
36	Polyphagia (HP:0002591)	2.28540154
37	Anencephaly (HP:0002323)	2.27693392
38	Cystic liver disease (HP:0006706)	2.26547273
39	Septo-optic dysplasia (HP:0100842)	2.25017560
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.21225704
41	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.19903400
42	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.16190110
43	Excessive salivation (HP:0003781)	2.11290048
44	Genetic anticipation (HP:0003743)	2.10981137
45	Pendular nystagmus (HP:0012043)	2.09583974
46	Febrile seizures (HP:0002373)	2.07964300
47	Dialeptic seizures (HP:0011146)	2.07301622
48	Congenital hepatic fibrosis (HP:0002612)	2.06784030
49	Retinal dysplasia (HP:0007973)	2.05919446
50	Protruding tongue (HP:0010808)	2.05234008
51	Type II lissencephaly (HP:0007260)	2.03264654
52	Renal hypoplasia (HP:0000089)	2.01848804
53	Focal seizures (HP:0007359)	2.01785811
54	Thyroid-stimulating hormone excess (HP:0002925)	2.00787769
55	Fair hair (HP:0002286)	1.99149552
56	Stomach cancer (HP:0012126)	1.97606860
57	Hypothermia (HP:0002045)	1.97258304
58	Polydipsia (HP:0001959)	1.97234602
59	Abnormal drinking behavior (HP:0030082)	1.97234602
60	Postaxial hand polydactyly (HP:0001162)	1.96999013
61	Tubular atrophy (HP:0000092)	1.96431513
62	Specific learning disability (HP:0001328)	1.95263928
63	Bony spicule pigmentary retinopathy (HP:0007737)	1.95095701
64	Lissencephaly (HP:0001339)	1.94669997
65	Decreased circulating renin level (HP:0003351)	1.93015492
66	Tubulointerstitial nephritis (HP:0001970)	1.92678302
67	Sclerocornea (HP:0000647)	1.91123475
68	Severe visual impairment (HP:0001141)	1.91081645
69	Preaxial hand polydactyly (HP:0001177)	1.90136336
70	Hemiparesis (HP:0001269)	1.89414648
71	Amyotrophic lateral sclerosis (HP:0007354)	1.88009329
72	3-Methylglutaconic aciduria (HP:0003535)	1.87446133
73	Postaxial foot polydactyly (HP:0001830)	1.87214415
74	Pachygyria (HP:0001302)	1.86901976
75	Oligodactyly (hands) (HP:0001180)	1.85795260
76	Abnormal ciliary motility (HP:0012262)	1.84582585
77	Cupped ear (HP:0000378)	1.83836995
78	Increased CSF lactate (HP:0002490)	1.83732602
79	Gastrointestinal atresia (HP:0002589)	1.82984707
80	Neoplasm of the adrenal cortex (HP:0100641)	1.81220950
81	Narrow forehead (HP:0000341)	1.76421362
82	Broad foot (HP:0001769)	1.76090362
83	Decreased testicular size (HP:0008734)	1.75772782
84	Male pseudohermaphroditism (HP:0000037)	1.75042550
85	Mitochondrial inheritance (HP:0001427)	1.74893473
86	Absent/shortened dynein arms (HP:0200106)	1.73766386
87	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.73766386
88	Papillary thyroid carcinoma (HP:0002895)	1.73530414
89	Atonic seizures (HP:0010819)	1.72940709
90	Astigmatism (HP:0000483)	1.72813822
91	Abnormal rod and cone electroretinograms (HP:0008323)	1.71966162
92	Acute necrotizing encephalopathy (HP:0006965)	1.71867333
93	Hepatoblastoma (HP:0002884)	1.71270997
94	Widely spaced teeth (HP:0000687)	1.70239118
95	Dyskinesia (HP:0100660)	1.70064631
96	Prominent nasal bridge (HP:0000426)	1.68672432
97	Hepatic necrosis (HP:0002605)	1.68551328
98	Retinitis pigmentosa (HP:0000510)	1.68404753
99	Aplasia/Hypoplasia of the lens (HP:0008063)	1.67390396
100	Abnormality of macular pigmentation (HP:0008002)	1.66575323

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.45226856
2	WNK3	3.05174118
3	INSRR	3.03032246
4	CASK	2.90617627
5	MAP4K2	2.72068340
6	MARK1	2.63919144
7	BMPR1B	2.28599032
8	NUAK1	2.26220666
9	MAP3K4	2.22058304
10	MAPK13	2.06404479
11	ZAK	1.86513595
12	STK38L	1.79404414
13	TRIM28	1.73161070
14	BCR	1.69853387
15	MAP2K7	1.65589893
16	ADRBK2	1.60604734
17	PLK4	1.52016051
18	CSNK1G1	1.49699659
19	LATS1	1.45825949
20	MKNK2	1.42163971
21	PINK1	1.39955352
22	CSNK1A1L	1.37970623
23	CSNK1G2	1.36814845
24	PLK2	1.36455901
25	CSNK1G3	1.34843377
26	DYRK2	1.31119528
27	GRK1	1.27039878
28	TAOK3	1.25815068
29	PAK3	1.25281734
30	ACVR1B	1.24007720
31	FGFR2	1.22446941
32	CDK19	1.15437689
33	EPHA4	1.15150619
34	AKT3	1.15018981
35	OXSR1	1.13390334
36	BRD4	1.08805955
37	PRKCE	1.08089132
38	ERBB3	1.07653966
39	DAPK2	1.06543243
40	PNCK	0.99357376
41	MKNK1	0.97379960
42	SRPK1	0.97019322
43	PRKCG	0.96134402
44	TNIK	0.93256411
45	NTRK3	0.88174928
46	STK3	0.84777717
47	CCNB1	0.84571532
48	MST4	0.83498673
49	SGK2	0.82678711
50	DYRK1A	0.75440509
51	PIK3CG	0.75314264
52	VRK1	0.72744501
53	PHKG2	0.72042058
54	PHKG1	0.72042058
55	STK39	0.71253169
56	DYRK3	0.70587607
57	PLK3	0.70415466
58	CAMK1G	0.66763629
59	WNK4	0.66198659
60	SGK223	0.65384164
61	SGK494	0.65384164
62	BRSK2	0.63108845
63	NTRK2	0.62698322
64	NLK	0.62369395
65	TLK1	0.60384062
66	OBSCN	0.59172034
67	PKN1	0.59133160
68	CSNK1D	0.57688680
69	EIF2AK3	0.54899780
70	TGFBR1	0.54459237
71	ADRBK1	0.53933325
72	CAMK2A	0.53786944
73	CSNK1A1	0.51107263
74	TXK	0.49623733
75	MINK1	0.48881798
76	CAMKK2	0.48751617
77	TNK2	0.48148534
78	EPHA3	0.47600837
79	ATM	0.47551015
80	MAP2K6	0.46965264
81	PRKACA	0.46641694
82	NME1	0.46157527
83	PTK2B	0.45879296
84	MAP2K4	0.44920297
85	BCKDK	0.44329471
86	UHMK1	0.44094222
87	PLK1	0.44001721
88	PRKACB	0.42063602
89	PRKG1	0.41243169
90	PRKAA1	0.40851767
91	CDC7	0.39606716
92	TEC	0.37661635
93	PIK3CA	0.36873757
94	RPS6KA4	0.36324644
95	ATR	0.36125660
96	STK11	0.35742631
97	CDK5	0.34624385
98	CAMK4	0.34113007
99	PRKCB	0.33322589
100	SGK1	0.32948123

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.28751566
2	Phototransduction_Homo sapiens_hsa04744	2.98227313
3	Butanoate metabolism_Homo sapiens_hsa00650	2.69214340
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.69015373
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.66434077
6	Protein export_Homo sapiens_hsa03060	2.53989494
7	Homologous recombination_Homo sapiens_hsa03440	2.37560098
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.31461250
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.20554930
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.03299960
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.98626119
12	Taste transduction_Homo sapiens_hsa04742	1.95153271
13	Olfactory transduction_Homo sapiens_hsa04740	1.93819455
14	RNA polymerase_Homo sapiens_hsa03020	1.92751096
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.91551799
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.88552345
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.87314031
18	GABAergic synapse_Homo sapiens_hsa04727	1.75171552
19	Basal transcription factors_Homo sapiens_hsa03022	1.74403080
20	Morphine addiction_Homo sapiens_hsa05032	1.70406660
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.69327237
22	Propanoate metabolism_Homo sapiens_hsa00640	1.64955979
23	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.61924229
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.59408855
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.58971345
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.54796043
27	Caffeine metabolism_Homo sapiens_hsa00232	1.51326387
28	Parkinsons disease_Homo sapiens_hsa05012	1.45390548
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.43943773
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.37810774
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.33778228
32	Circadian entrainment_Homo sapiens_hsa04713	1.30536047
33	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.28985112
34	Regulation of autophagy_Homo sapiens_hsa04140	1.28177304
35	Glutamatergic synapse_Homo sapiens_hsa04724	1.28117689
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.25829728
37	Collecting duct acid secretion_Homo sapiens_hsa04966	1.23496509
38	RNA degradation_Homo sapiens_hsa03018	1.22339222
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.17149672
40	beta-Alanine metabolism_Homo sapiens_hsa00410	1.16749639
41	Huntingtons disease_Homo sapiens_hsa05016	1.15084604
42	Serotonergic synapse_Homo sapiens_hsa04726	1.14629949
43	Circadian rhythm_Homo sapiens_hsa04710	1.12287794
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.06935265
45	Peroxisome_Homo sapiens_hsa04146	1.05249500
46	ABC transporters_Homo sapiens_hsa02010	1.02252883
47	Steroid biosynthesis_Homo sapiens_hsa00100	1.00366405
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.99161540
49	Insulin secretion_Homo sapiens_hsa04911	0.95108444
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93077990
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.89835282
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.89387156
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85657594
54	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.85074294
55	Alzheimers disease_Homo sapiens_hsa05010	0.84628971
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80288612
57	Cardiac muscle contraction_Homo sapiens_hsa04260	0.79647276
58	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.78848749
59	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.76987010
60	Purine metabolism_Homo sapiens_hsa00230	0.75435120
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.75123874
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.73035145
63	Retinol metabolism_Homo sapiens_hsa00830	0.72965554
64	Calcium signaling pathway_Homo sapiens_hsa04020	0.69324461
65	Asthma_Homo sapiens_hsa05310	0.65179998
66	Amphetamine addiction_Homo sapiens_hsa05031	0.64247256
67	Salivary secretion_Homo sapiens_hsa04970	0.60168787
68	Cocaine addiction_Homo sapiens_hsa05030	0.59953728
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59519629
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59449328
71	Metabolic pathways_Homo sapiens_hsa01100	0.59440795
72	Long-term depression_Homo sapiens_hsa04730	0.57862475
73	Type I diabetes mellitus_Homo sapiens_hsa04940	0.57698332
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.56247935
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.54197045
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52969000
77	Oocyte meiosis_Homo sapiens_hsa04114	0.52312307
78	RNA transport_Homo sapiens_hsa03013	0.48170199
79	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.47876129
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47095784
81	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.47067419
82	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.46289876
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.45899557
84	Fatty acid degradation_Homo sapiens_hsa00071	0.44018127
85	Histidine metabolism_Homo sapiens_hsa00340	0.43665447
86	Lysine degradation_Homo sapiens_hsa00310	0.42601578
87	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.41415256
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.41398647
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39937015
90	One carbon pool by folate_Homo sapiens_hsa00670	0.39228762
91	cAMP signaling pathway_Homo sapiens_hsa04024	0.36961687
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.36467317
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.32710076
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32401932
95	Cholinergic synapse_Homo sapiens_hsa04725	0.32288145
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.30548787
97	Fatty acid elongation_Homo sapiens_hsa00062	0.29915828
98	Mismatch repair_Homo sapiens_hsa03430	0.29201671
99	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.28878836
100	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.27388212

ZNF585A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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