ZNF586

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)3.80091253
2positive regulation of granulocyte differentiation (GO:0030854)3.79205820
3histone mRNA catabolic process (GO:0071044)3.59559132
4histone H2A acetylation (GO:0043968)3.55901333
5regulation of meiosis I (GO:0060631)3.50790896
6negative regulation of cAMP-mediated signaling (GO:0043951)3.47689549
7DNA double-strand break processing (GO:0000729)3.39047522
8piRNA metabolic process (GO:0034587)3.35612573
9positive regulation of interleukin-17 production (GO:0032740)3.30793415
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.29576783
11neural tube formation (GO:0001841)3.18221877
12positive regulation of gamma-delta T cell activation (GO:0046645)3.12613243
13synapsis (GO:0007129)3.09117590
14histone H3-K4 trimethylation (GO:0080182)3.08960924
15interferon-gamma production (GO:0032609)3.08038290
16G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.06672888
17monoubiquitinated protein deubiquitination (GO:0035520)3.04815121
18positive regulation of histone H3-K4 methylation (GO:0051571)3.01834826
19regulation of B cell apoptotic process (GO:0002902)2.97055509
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93438956
21positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.91926571
22RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.81944463
23protein K11-linked deubiquitination (GO:0035871)2.81642794
24regulation of regulatory T cell differentiation (GO:0045589)2.80817737
25gene silencing by RNA (GO:0031047)2.80796913
26regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.80531589
27pyrimidine dimer repair (GO:0006290)2.76107128
28negative regulation of B cell apoptotic process (GO:0002903)2.75906937
29regulation of B cell differentiation (GO:0045577)2.73247675
30purinergic nucleotide receptor signaling pathway (GO:0035590)2.72616405
31positive regulation of DNA recombination (GO:0045911)2.72264084
32positive regulation of B cell differentiation (GO:0045579)2.71411047
33cellular response to interleukin-15 (GO:0071350)2.68696632
34histone mRNA metabolic process (GO:0008334)2.68489943
35somatic hypermutation of immunoglobulin genes (GO:0016446)2.67787005
36somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67787005
37DNA demethylation (GO:0080111)2.67071387
38regulation of histone H3-K9 methylation (GO:0051570)2.66224302
39negative regulation of thymocyte apoptotic process (GO:0070244)2.64769032
40histone H3-K9 methylation (GO:0051567)2.63912788
41neutrophil mediated immunity (GO:0002446)2.62494629
42DNA methylation involved in gamete generation (GO:0043046)2.61897674
43positive regulation of isotype switching (GO:0045830)2.55258061
44regulation of memory T cell differentiation (GO:0043380)2.54966090
45negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.54558884
46negative regulation of translation, ncRNA-mediated (GO:0040033)2.54558884
47regulation of translation, ncRNA-mediated (GO:0045974)2.54558884
48regulation of alpha-beta T cell proliferation (GO:0046640)2.54370980
49positive regulation of mitotic sister chromatid separation (GO:1901970)2.53562056
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.53562056
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.53562056
52protein K63-linked deubiquitination (GO:0070536)2.53538328
53mast cell activation (GO:0045576)2.53378430
54double-strand break repair via homologous recombination (GO:0000724)2.53129695
55negative regulation of lymphocyte apoptotic process (GO:0070229)2.52811262
56activated T cell proliferation (GO:0050798)2.52355555
57recombinational repair (GO:0000725)2.51776926
58DNA deamination (GO:0045006)2.51609359
59mast cell degranulation (GO:0043303)2.50856486
60mast cell activation involved in immune response (GO:0002279)2.50856486
61myeloid leukocyte mediated immunity (GO:0002444)2.47695964
62response to interleukin-15 (GO:0070672)2.47532684
63regulation of female gonad development (GO:2000194)2.46588336
64positive regulation of alpha-beta T cell proliferation (GO:0046641)2.45294566
65positive T cell selection (GO:0043368)2.42988089
66regulation of gamma-delta T cell differentiation (GO:0045586)2.42836060
67negative regulation of T cell apoptotic process (GO:0070233)2.41786171
68regulation of gamma-delta T cell activation (GO:0046643)2.41464626
69regulation of thymocyte apoptotic process (GO:0070243)2.38004076
70B cell receptor signaling pathway (GO:0050853)2.37464977
71rRNA catabolic process (GO:0016075)2.36218625
72DNA catabolic process, exonucleolytic (GO:0000738)2.36016620
73tachykinin receptor signaling pathway (GO:0007217)2.35746614
74detection of other organism (GO:0098543)2.33438632
75histone H3-K9 modification (GO:0061647)2.32267400
76negative regulation of DNA recombination (GO:0045910)2.31692604
77peptidyl-lysine trimethylation (GO:0018023)2.30930880
78centriole replication (GO:0007099)2.30074136
79single strand break repair (GO:0000012)2.29953504
80protein K48-linked deubiquitination (GO:0071108)2.29150162
81establishment of protein localization to Golgi (GO:0072600)2.29032298
82B cell mediated immunity (GO:0019724)2.28399268
83mucosal-associated lymphoid tissue development (GO:0048537)2.27430934
84Peyers patch development (GO:0048541)2.27430934
85regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.26064990
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.25397650
87negative regulation of gene expression, epigenetic (GO:0045814)2.24597780
88hepatocyte apoptotic process (GO:0097284)2.23163845
89negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.22921897
90negative regulation of T-helper cell differentiation (GO:0045623)2.22921897
91B cell activation (GO:0042113)2.22711863
92regulation of interleukin-17 production (GO:0032660)2.22003307
93detection of bacterium (GO:0016045)2.21648503
94negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.21278028
95rRNA methylation (GO:0031167)2.21178392
96indolalkylamine metabolic process (GO:0006586)2.21025598
97alpha-beta T cell differentiation (GO:0046632)2.20966851
98replication fork processing (GO:0031297)2.20772615
99regulation of isotype switching to IgG isotypes (GO:0048302)2.20574871
100embryonic hemopoiesis (GO:0035162)2.20091913

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.81307924
2ZNF274_21170338_ChIP-Seq_K562_Hela3.68281578
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.11893990
4NOTCH1_21737748_ChIP-Seq_TLL_Human2.77372183
5GATA1_22025678_ChIP-Seq_K562_Human2.59374906
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42779068
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.41400884
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36779709
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.30552122
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30390257
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.28483375
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.28391676
13IGF1R_20145208_ChIP-Seq_DFB_Human2.27692861
14* VDR_23849224_ChIP-Seq_CD4+_Human2.26085702
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.24733936
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15259636
17VDR_22108803_ChIP-Seq_LS180_Human2.12983586
18E2F7_22180533_ChIP-Seq_HELA_Human2.12824919
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04812720
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03744143
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03412426
22ELK1_19687146_ChIP-ChIP_HELA_Human1.97599835
23EWS_26573619_Chip-Seq_HEK293_Human1.94395840
24* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93138867
25FUS_26573619_Chip-Seq_HEK293_Human1.81581238
26IRF1_19129219_ChIP-ChIP_H3396_Human1.81442729
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77247178
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.74185286
29CIITA_25753668_ChIP-Seq_RAJI_Human1.70819302
30RUNX_20019798_ChIP-Seq_JUKART_Human1.68242993
31SCL_19346495_ChIP-Seq_HPC-7_Human1.67543861
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67363054
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66911843
34MYB_26560356_Chip-Seq_TH2_Human1.65188757
35FOXP3_21729870_ChIP-Seq_TREG_Human1.64231101
36TAF15_26573619_Chip-Seq_HEK293_Human1.59999909
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57687791
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.54886473
39ER_23166858_ChIP-Seq_MCF-7_Human1.54569353
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.51804794
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49199023
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46886764
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44278914
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43628026
45GATA3_26560356_Chip-Seq_TH2_Human1.42310927
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37281913
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37216354
48GATA3_27048872_Chip-Seq_THYMUS_Human1.37037813
49P300_19829295_ChIP-Seq_ESCs_Human1.36967535
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36895045
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36332248
52CBP_20019798_ChIP-Seq_JUKART_Human1.33919029
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33919029
54MYC_18940864_ChIP-ChIP_HL60_Human1.33822876
55SPI1_23547873_ChIP-Seq_NB4_Human1.32854815
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32833687
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31218218
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29875831
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29174644
60GBX2_23144817_ChIP-Seq_PC3_Human1.27213797
61MYB_26560356_Chip-Seq_TH1_Human1.27032923
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26924967
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26476249
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21651920
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.19196138
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14559905
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.13620508
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13507941
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13179792
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11013882
71* TP63_19390658_ChIP-ChIP_HaCaT_Human1.10702151
72* ETS1_20019798_ChIP-Seq_JURKAT_Human1.10385286
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08240630
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.08185228
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.06988100
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06842269
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05561171
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05014786
79STAT3_23295773_ChIP-Seq_U87_Human1.04148283
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03273454
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03027899
82TP53_22573176_ChIP-Seq_HFKS_Human1.02853960
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02367085
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02367085
85IRF8_27001747_Chip-Seq_BMDM_Mouse1.00726552
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99684485
87SALL4_22934838_ChIP-ChIP_CD34+_Human0.98377400
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97234997
89* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96295472
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95707765
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94429340
92VDR_24787735_ChIP-Seq_THP-1_Human0.94164524
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93753582
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92840872
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90442909
96SMAD4_21799915_ChIP-Seq_A2780_Human0.88368386
97TCF4_23295773_ChIP-Seq_U87_Human0.87925144
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87595885
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.86846750
100GATA3_26560356_Chip-Seq_TH1_Human0.86567229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.50195931
2MP0008877_abnormal_DNA_methylation3.04430031
3MP0002102_abnormal_ear_morphology2.98339050
4MP0001835_abnormal_antigen_presentation2.84079041
5MP0008058_abnormal_DNA_repair2.68700902
6MP0003763_abnormal_thymus_physiology2.66181456
7MP0005397_hematopoietic_system_phenotyp2.56004723
8MP0001545_abnormal_hematopoietic_system2.56004723
9MP0005075_abnormal_melanosome_morpholog2.55245397
10MP0003724_increased_susceptibility_to2.46886276
11MP0005671_abnormal_response_to2.44840686
12MP0010094_abnormal_chromosome_stability2.43926125
13MP0002138_abnormal_hepatobiliary_system2.25769811
14MP0000569_abnormal_digit_pigmentation2.24272891
15MP0001800_abnormal_humoral_immune2.08898379
16MP0000015_abnormal_ear_pigmentation1.89402179
17MP0002009_preneoplasia1.71806614
18MP0000372_irregular_coat_pigmentation1.69893570
19MP0001986_abnormal_taste_sensitivity1.69640768
20MP0000465_gastrointestinal_hemorrhage1.68689920
21MP0002452_abnormal_antigen_presenting1.65261784
22MP0002398_abnormal_bone_marrow1.65074751
23MP0002420_abnormal_adaptive_immunity1.62967861
24MP0002166_altered_tumor_susceptibility1.62706334
25MP0001819_abnormal_immune_cell1.60784978
26MP0002723_abnormal_immune_serum1.60079083
27MP0005000_abnormal_immune_tolerance1.57448862
28MP0008995_early_reproductive_senescence1.56228004
29MP0000689_abnormal_spleen_morphology1.51473546
30MP0002396_abnormal_hematopoietic_system1.50168279
31MP0009278_abnormal_bone_marrow1.48337024
32MP0004808_abnormal_hematopoietic_stem1.46467541
33MP0002148_abnormal_hypersensitivity_rea1.44788135
34MP0005377_hearing/vestibular/ear_phenot1.42545607
35MP0003878_abnormal_ear_physiology1.42545607
36MP0003303_peritoneal_inflammation1.41657492
37MP0000716_abnormal_immune_system1.40468723
38MP0009785_altered_susceptibility_to1.36538066
39MP0003646_muscle_fatigue1.34659648
40MP0000703_abnormal_thymus_morphology1.34589885
41MP0002006_tumorigenesis1.34087336
42MP0003172_abnormal_lysosome_physiology1.31469737
43MP0002405_respiratory_system_inflammati1.30303743
44MP0005174_abnormal_tail_pigmentation1.29740852
45MP0002419_abnormal_innate_immunity1.29705940
46MP0003436_decreased_susceptibility_to1.29484425
47MP0006292_abnormal_olfactory_placode1.29357798
48MP0002722_abnormal_immune_system1.29212432
49MP0004381_abnormal_hair_follicle1.28248490
50MP0006035_abnormal_mitochondrial_morpho1.24743628
51MP0005253_abnormal_eye_physiology1.23504798
52MP0001790_abnormal_immune_system1.22601792
53MP0005387_immune_system_phenotype1.22601792
54MP0003786_premature_aging1.22265080
55MP0005084_abnormal_gallbladder_morpholo1.21632313
56MP0003787_abnormal_imprinting1.20917954
57MP0003111_abnormal_nucleus_morphology1.18442612
58MP0002429_abnormal_blood_cell1.13424165
59MP0005645_abnormal_hypothalamus_physiol1.12873652
60MP0003718_maternal_effect1.10659834
61MP0002928_abnormal_bile_duct1.10496497
62MP0002095_abnormal_skin_pigmentation1.10230953
63MP0005464_abnormal_platelet_physiology1.09852703
64MP0003183_abnormal_peptide_metabolism1.09716792
65MP0005025_abnormal_response_to1.07339598
66MP0001929_abnormal_gametogenesis1.06646465
67MP0001853_heart_inflammation1.02919224
68MP0003077_abnormal_cell_cycle1.02732689
69MP0005310_abnormal_salivary_gland1.01740778
70MP0005551_abnormal_eye_electrophysiolog0.99349839
71MP0009764_decreased_sensitivity_to0.97114304
72MP0006072_abnormal_retinal_apoptosis0.97042970
73MP0004215_abnormal_myocardial_fiber0.91308625
74MP0003221_abnormal_cardiomyocyte_apopto0.89764423
75MP0000685_abnormal_immune_system0.88516860
76MP0008260_abnormal_autophagy0.87202271
77MP0008789_abnormal_olfactory_epithelium0.85516109
78MP0002019_abnormal_tumor_incidence0.84921235
79MP0001845_abnormal_inflammatory_respons0.84203275
80MP0005410_abnormal_fertilization0.80804111
81MP0008007_abnormal_cellular_replicative0.80575872
82MP0005367_renal/urinary_system_phenotyp0.80267993
83MP0000516_abnormal_urinary_system0.80267993
84MP0003300_gastrointestinal_ulcer0.80231220
85MP0003828_pulmonary_edema0.77258122
86MP0003656_abnormal_erythrocyte_physiolo0.76321033
87MP0002210_abnormal_sex_determination0.76305858
88MP0003698_abnormal_male_reproductive0.75502779
89MP0001119_abnormal_female_reproductive0.74646022
90MP0003195_calcinosis0.73758000
91MP0000427_abnormal_hair_cycle0.70997968
92MP0001919_abnormal_reproductive_system0.69244217
93MP0000371_diluted_coat_color0.68933180
94MP0000653_abnormal_sex_gland0.68517905
95MP0001764_abnormal_homeostasis0.68508257
96MP0005266_abnormal_metabolism0.68499685
97MP0003567_abnormal_fetal_cardiomyocyte0.67833497
98MP0004147_increased_porphyrin_level0.66465185
99MP0001145_abnormal_male_reproductive0.66010531
100MP0003943_abnormal_hepatobiliary_system0.63091550

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)3.77535709
2Stomatitis (HP:0010280)3.74212585
3Panhypogammaglobulinemia (HP:0003139)3.54829106
4Thyroiditis (HP:0100646)3.43323634
5Abnormality of B cell number (HP:0010975)3.39104511
6Severe combined immunodeficiency (HP:0004430)3.19964459
7Neoplasm of the adrenal cortex (HP:0100641)3.10181438
8B lymphocytopenia (HP:0010976)2.96312348
9T lymphocytopenia (HP:0005403)2.94963281
10Stomach cancer (HP:0012126)2.91462386
11Abnormality of T cell number (HP:0011839)2.85886626
12Combined immunodeficiency (HP:0005387)2.73159997
13Elevated erythrocyte sedimentation rate (HP:0003565)2.70558102
14Abnormality of eosinophils (HP:0001879)2.64091583
15Attenuation of retinal blood vessels (HP:0007843)2.63513869
16Pancreatic cysts (HP:0001737)2.60516516
17Eosinophilia (HP:0001880)2.59699084
18Abnormality of chromosome stability (HP:0003220)2.58811991
19Abnormal delayed hypersensitivity skin test (HP:0002963)2.55706153
20IgG deficiency (HP:0004315)2.54563470
21Abnormal rod and cone electroretinograms (HP:0008323)2.48404730
22Hypoplasia of the thymus (HP:0000778)2.46256687
23Recurrent fungal infections (HP:0002841)2.40595640
24Encephalitis (HP:0002383)2.37258506
25Colon cancer (HP:0003003)2.32515204
26Granulocytopenia (HP:0001913)2.30850527
27Abnormality of lateral ventricle (HP:0030047)2.25128963
28Congenital stationary night blindness (HP:0007642)2.21336812
29Leukocytosis (HP:0001974)2.20768521
30Pancreatic fibrosis (HP:0100732)2.20706613
31True hermaphroditism (HP:0010459)2.20549538
32Agammaglobulinemia (HP:0004432)2.20536514
33Bile duct proliferation (HP:0001408)2.18733428
34Abnormal biliary tract physiology (HP:0012439)2.18733428
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.18206542
36Abnormality of T cells (HP:0002843)2.15125314
37Abnormality of the prostate (HP:0008775)2.14955333
38Absent/shortened dynein arms (HP:0200106)2.11849676
39Dynein arm defect of respiratory motile cilia (HP:0012255)2.11849676
40Hypochromic microcytic anemia (HP:0004840)2.11254710
41Meningitis (HP:0001287)2.07435512
42Optic neuritis (HP:0100653)2.06528580
43Retrobulbar optic neuritis (HP:0100654)2.06528580
44Tubulointerstitial nephritis (HP:0001970)2.05799581
45Basal cell carcinoma (HP:0002671)2.04648487
46Progressive inability to walk (HP:0002505)2.04098688
47Clubbing of toes (HP:0100760)2.03763793
48Constricted visual fields (HP:0001133)2.03194351
49Abnormality of midbrain morphology (HP:0002418)2.02451727
50Molar tooth sign on MRI (HP:0002419)2.02451727
51Pendular nystagmus (HP:0012043)2.00981609
52Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98652905
53Abnormality of the ileum (HP:0001549)1.96821130
54Hyperventilation (HP:0002883)1.94304478
55Meckel diverticulum (HP:0002245)1.93412517
56Nephronophthisis (HP:0000090)1.93053491
57Recurrent bacterial skin infections (HP:0005406)1.92595774
58Amyotrophic lateral sclerosis (HP:0007354)1.92437564
59Abnormality of the preputium (HP:0100587)1.92340341
60Recurrent cutaneous fungal infections (HP:0011370)1.92240946
61Chronic mucocutaneous candidiasis (HP:0002728)1.92240946
62Bony spicule pigmentary retinopathy (HP:0007737)1.89610104
63Myositis (HP:0100614)1.88501483
64Methylmalonic acidemia (HP:0002912)1.88034463
65Acute myeloid leukemia (HP:0004808)1.88010313
66Fair hair (HP:0002286)1.87836471
67Carpal bone hypoplasia (HP:0001498)1.87088828
683-Methylglutaconic aciduria (HP:0003535)1.86266812
69IgM deficiency (HP:0002850)1.85877327
70Acute lymphatic leukemia (HP:0006721)1.85848011
71Recurrent viral infections (HP:0004429)1.85777877
72Severe visual impairment (HP:0001141)1.85513425
73Acute hepatic failure (HP:0006554)1.85338806
74Gaze-evoked nystagmus (HP:0000640)1.85209403
75Chronic hepatic failure (HP:0100626)1.84935612
76Decreased central vision (HP:0007663)1.82931388
77Myelodysplasia (HP:0002863)1.81996048
78Genetic anticipation (HP:0003743)1.80778595
79Medulloblastoma (HP:0002885)1.79498908
80Sloping forehead (HP:0000340)1.77935158
81Prostate neoplasm (HP:0100787)1.76582549
82Absent speech (HP:0001344)1.75702940
83Bone marrow hypocellularity (HP:0005528)1.74474055
84Abnormality of the renal medulla (HP:0100957)1.72128167
85Hypoproteinemia (HP:0003075)1.71241480
86Abnormality of male internal genitalia (HP:0000022)1.70828219
87Lymphoma (HP:0002665)1.70762027
88Abnormality of the renal cortex (HP:0011035)1.70413382
89Mediastinal lymphadenopathy (HP:0100721)1.70001295
90Medial flaring of the eyebrow (HP:0010747)1.69915191
91Abolished electroretinogram (ERG) (HP:0000550)1.69017024
92Recurrent sinusitis (HP:0011108)1.65954110
93Hypoplastic iliac wings (HP:0002866)1.65705258
94Chromsome breakage (HP:0040012)1.65357499
95Abnormality of T cell physiology (HP:0011840)1.65281791
96Chronic diarrhea (HP:0002028)1.62451100
97Keratoconjunctivitis (HP:0001096)1.60794381
98Chest pain (HP:0100749)1.59820014
99Recurrent abscess formation (HP:0002722)1.59391308
100Neutropenia (HP:0001875)1.58846205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.91386312
2WNK32.79681351
3NUAK12.69930350
4TAOK32.54398610
5TXK2.26168951
6TEC2.13370463
7EIF2AK32.03808503
8CDK191.97161569
9BLK1.92865513
10ZAK1.92412655
11BRD41.89571990
12ACVR1B1.87935934
13MARK31.79440819
14MAPK131.68361755
15PDK21.57133872
16EPHA31.54797900
17BRSK21.52599391
18TRIM281.49566398
19MAP4K11.48998420
20BTK1.43461080
21KIT1.43265570
22SYK1.41115155
23STK38L1.38188506
24BMPR1B1.35406074
25TNK21.33721182
26GRK61.27636944
27BMPR21.25817546
28PIM11.24767429
29MAP3K141.23922305
30MKNK11.23295143
31FES1.22500084
32MKNK21.19736354
33JAK31.16379231
34IKBKB1.11464499
35DYRK31.08692829
36LYN1.05215987
37IKBKE1.03339160
38MAP4K21.01824780
39MATK0.98474701
40IRAK40.96498845
41ITK0.93835918
42HCK0.93295284
43ERBB30.92746246
44RPS6KA40.92558203
45OXSR10.91519335
46SIK30.90037251
47CDC70.87460165
48IRAK10.86128615
49NLK0.84517561
50ATR0.81406032
51CSNK1G10.81010312
52PRKCQ0.80772588
53ADRBK20.80518765
54GRK10.77787292
55PLK30.77753834
56CHEK20.77409597
57PIK3CG0.76949569
58CSNK1G30.76593445
59LCK0.76097848
60VRK10.75257914
61CSNK1A1L0.75154974
62PINK10.73826453
63CSNK1G20.71313098
64GRK70.69770819
65MST40.68947808
66PLK40.68947692
67CSK0.68584769
68ZAP700.68419363
69SRPK10.68105479
70PTK2B0.67928853
71SGK20.67636184
72PLK20.63913400
73RIPK40.63327810
74PLK10.63292112
75RPS6KA50.62032969
76MAP2K30.58253188
77ATM0.56791413
78JAK20.55297640
79TNIK0.54543987
80FGR0.54500550
81EGFR0.53089436
82CDK30.52110964
83CCNB10.52105389
84FLT30.50080743
85TAF10.50047235
86CSNK1D0.49825532
87TIE10.48707712
88NEK60.47220465
89OBSCN0.47186085
90MAP3K40.46535449
91CLK10.45769942
92AKT30.45638743
93STK390.44522884
94GRK50.39092192
95CHEK10.38785318
96LATS10.38617092
97BCKDK0.38258350
98ABL10.38189237
99TLK10.36364278
100JAK10.35979710

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.11183821
2Non-homologous end-joining_Homo sapiens_hsa034502.91433130
3Fanconi anemia pathway_Homo sapiens_hsa034602.79577414
4Allograft rejection_Homo sapiens_hsa053302.54160362
5Asthma_Homo sapiens_hsa053102.53135515
6Graft-versus-host disease_Homo sapiens_hsa053322.48733446
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.44849485
8Autoimmune thyroid disease_Homo sapiens_hsa053202.36335798
9Homologous recombination_Homo sapiens_hsa034402.24678209
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22974663
11Basal transcription factors_Homo sapiens_hsa030222.11138500
12Type I diabetes mellitus_Homo sapiens_hsa049402.08517990
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97309980
14Regulation of autophagy_Homo sapiens_hsa041401.66695195
15Hematopoietic cell lineage_Homo sapiens_hsa046401.60831834
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60603392
17Phototransduction_Homo sapiens_hsa047441.57291413
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50282486
19Leishmaniasis_Homo sapiens_hsa051401.40174673
20RNA degradation_Homo sapiens_hsa030181.37434560
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36294851
22Mismatch repair_Homo sapiens_hsa034301.34850286
23RNA polymerase_Homo sapiens_hsa030201.34038114
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.32125055
25Herpes simplex infection_Homo sapiens_hsa051681.28519698
26Proteasome_Homo sapiens_hsa030501.28455883
27p53 signaling pathway_Homo sapiens_hsa041151.26860814
28Antigen processing and presentation_Homo sapiens_hsa046121.26050439
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.25681306
30T cell receptor signaling pathway_Homo sapiens_hsa046601.25211418
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22375861
32Base excision repair_Homo sapiens_hsa034101.20710137
33Systemic lupus erythematosus_Homo sapiens_hsa053221.17647372
34RNA transport_Homo sapiens_hsa030131.17517343
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15670833
36Measles_Homo sapiens_hsa051621.15602814
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13057796
38DNA replication_Homo sapiens_hsa030301.12879540
39Taste transduction_Homo sapiens_hsa047421.12485993
40Legionellosis_Homo sapiens_hsa051341.11390304
41Spliceosome_Homo sapiens_hsa030401.10722223
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09736299
43Osteoclast differentiation_Homo sapiens_hsa043801.05643048
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04791999
45B cell receptor signaling pathway_Homo sapiens_hsa046621.03263374
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02750648
47Tuberculosis_Homo sapiens_hsa051521.01980462
48Dorso-ventral axis formation_Homo sapiens_hsa043201.01805994
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99674440
50Protein export_Homo sapiens_hsa030600.94881978
51Olfactory transduction_Homo sapiens_hsa047400.94070718
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92185994
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91816993
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91774784
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90993052
56Linoleic acid metabolism_Homo sapiens_hsa005910.90582352
57Staphylococcus aureus infection_Homo sapiens_hsa051500.89608328
58Rheumatoid arthritis_Homo sapiens_hsa053230.88999553
59Cell cycle_Homo sapiens_hsa041100.87200677
60Epstein-Barr virus infection_Homo sapiens_hsa051690.84706372
61Viral myocarditis_Homo sapiens_hsa054160.80086013
62Ether lipid metabolism_Homo sapiens_hsa005650.76095340
63FoxO signaling pathway_Homo sapiens_hsa040680.75970766
64mRNA surveillance pathway_Homo sapiens_hsa030150.74349929
65Viral carcinogenesis_Homo sapiens_hsa052030.74061490
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72257464
67Influenza A_Homo sapiens_hsa051640.71592702
68Nucleotide excision repair_Homo sapiens_hsa034200.70342627
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70314628
70Caffeine metabolism_Homo sapiens_hsa002320.69288041
71Selenocompound metabolism_Homo sapiens_hsa004500.67504171
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62997139
73Circadian rhythm_Homo sapiens_hsa047100.61496138
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60466330
75Propanoate metabolism_Homo sapiens_hsa006400.60274501
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57048709
77TNF signaling pathway_Homo sapiens_hsa046680.56341005
78Oocyte meiosis_Homo sapiens_hsa041140.55940374
79Platelet activation_Homo sapiens_hsa046110.55423284
80Toxoplasmosis_Homo sapiens_hsa051450.54121139
81Alcoholism_Homo sapiens_hsa050340.53131969
82Purine metabolism_Homo sapiens_hsa002300.51984930
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.51561668
84Peroxisome_Homo sapiens_hsa041460.51360022
85Butanoate metabolism_Homo sapiens_hsa006500.49867078
86Arachidonic acid metabolism_Homo sapiens_hsa005900.47974750
87Lysine degradation_Homo sapiens_hsa003100.47653515
88Chemokine signaling pathway_Homo sapiens_hsa040620.46982300
89Hepatitis B_Homo sapiens_hsa051610.46440685
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46009729
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46004758
92Pyrimidine metabolism_Homo sapiens_hsa002400.42519923
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39342606
94HTLV-I infection_Homo sapiens_hsa051660.39259242
95Acute myeloid leukemia_Homo sapiens_hsa052210.37325277
96Morphine addiction_Homo sapiens_hsa050320.31043739
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30728972
98Renin-angiotensin system_Homo sapiens_hsa046140.25971726
99Malaria_Homo sapiens_hsa051440.25504770
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.24282299

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