ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.85299394
2	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.79863972
3	regulation of translation, ncRNA-mediated (GO:0045974)	4.79863972
4	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.79863972
5	regulation of hippo signaling (GO:0035330)	4.16584990
6	L-fucose catabolic process (GO:0042355)	4.06194515
7	fucose catabolic process (GO:0019317)	4.06194515
8	L-fucose metabolic process (GO:0042354)	4.06194515
9	kidney morphogenesis (GO:0060993)	3.92521848
10	neural tube formation (GO:0001841)	3.47714730
11	regulation of posttranscriptional gene silencing (GO:0060147)	3.46907585
12	regulation of gene silencing by miRNA (GO:0060964)	3.46907585
13	regulation of gene silencing by RNA (GO:0060966)	3.46907585
14	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.42707815
15	cytoplasmic mRNA processing body assembly (GO:0033962)	3.38950090
16	regulation of mesoderm development (GO:2000380)	3.30310425
17	indole-containing compound catabolic process (GO:0042436)	3.26687440
18	indolalkylamine catabolic process (GO:0046218)	3.26687440
19	tryptophan catabolic process (GO:0006569)	3.26687440
20	sulfation (GO:0051923)	3.25716757
21	somite rostral/caudal axis specification (GO:0032525)	3.20203280
22	indolalkylamine metabolic process (GO:0006586)	3.17501705
23	interkinetic nuclear migration (GO:0022027)	3.16853544
24	regulation of pigment cell differentiation (GO:0050932)	3.16635167
25	kynurenine metabolic process (GO:0070189)	3.04361573
26	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.02903083
27	monoubiquitinated protein deubiquitination (GO:0035520)	2.95885329
28	establishment of protein localization to Golgi (GO:0072600)	2.94250498
29	spinal cord motor neuron differentiation (GO:0021522)	2.92065731
30	response to pheromone (GO:0019236)	2.87831602
31	protein K11-linked deubiquitination (GO:0035871)	2.84481921
32	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.82640415
33	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.82434625
34	cellular ketone body metabolic process (GO:0046950)	2.81718867
35	tryptophan metabolic process (GO:0006568)	2.80756405
36	gamma-aminobutyric acid transport (GO:0015812)	2.80336325
37	histone H3-K4 trimethylation (GO:0080182)	2.76353695
38	histone H3-K9 methylation (GO:0051567)	2.75598051
39	reciprocal DNA recombination (GO:0035825)	2.75135387
40	reciprocal meiotic recombination (GO:0007131)	2.75135387
41	neuronal action potential (GO:0019228)	2.72936963
42	microtubule anchoring (GO:0034453)	2.72881231
43	DNA deamination (GO:0045006)	2.71729476
44	snRNA transcription (GO:0009301)	2.70714665
45	positive regulation of developmental pigmentation (GO:0048087)	2.70075436
46	regulation of establishment of cell polarity (GO:2000114)	2.69682635
47	embryonic axis specification (GO:0000578)	2.65856486
48	reflex (GO:0060004)	2.64567416
49	double-strand break repair via homologous recombination (GO:0000724)	2.64549713
50	nonmotile primary cilium assembly (GO:0035058)	2.62771909
51	recombinational repair (GO:0000725)	2.62133114
52	regulation of telomere maintenance (GO:0032204)	2.61904137
53	dorsal/ventral axis specification (GO:0009950)	2.58618051
54	centriole replication (GO:0007099)	2.58326424
55	head development (GO:0060322)	2.56111245
56	signal transduction involved in regulation of gene expression (GO:0023019)	2.55777509
57	oxidative demethylation (GO:0070989)	2.53772380
58	nephron tubule morphogenesis (GO:0072078)	2.52863160
59	nephron epithelium morphogenesis (GO:0072088)	2.52863160
60	replication fork processing (GO:0031297)	2.49314071
61	embryonic pattern specification (GO:0009880)	2.49040610
62	regulation of action potential (GO:0098900)	2.48028797
63	protein prenylation (GO:0018342)	2.47705037
64	prenylation (GO:0097354)	2.47705037
65	ketone body metabolic process (GO:1902224)	2.47669624
66	regulation of DNA endoreduplication (GO:0032875)	2.46800702
67	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.46713974
68	cornea development in camera-type eye (GO:0061303)	2.46513154
69	positive regulation of mRNA catabolic process (GO:0061014)	2.45942520
70	protein K48-linked deubiquitination (GO:0071108)	2.45841654
71	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.45772037
72	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.45772037
73	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.44796880
74	nodal signaling pathway (GO:0038092)	2.43676907
75	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.42741315
76	cilium organization (GO:0044782)	2.42370396
77	hindbrain development (GO:0030902)	2.42201619
78	detection of light stimulus involved in visual perception (GO:0050908)	2.40919814
79	detection of light stimulus involved in sensory perception (GO:0050962)	2.40919814
80	epithelial cilium movement (GO:0003351)	2.40105490
81	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.39358503
82	limb bud formation (GO:0060174)	2.38936409
83	somite development (GO:0061053)	2.38886146
84	histone-serine phosphorylation (GO:0035404)	2.38672502
85	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.38475157
86	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.38475157
87	cilium morphogenesis (GO:0060271)	2.38434911
88	pericardium development (GO:0060039)	2.38082344
89	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.38078967
90	rRNA catabolic process (GO:0016075)	2.37966616
91	indole-containing compound metabolic process (GO:0042430)	2.37942014
92	cellular response to ATP (GO:0071318)	2.37282188
93	pre-miRNA processing (GO:0031054)	2.36844446
94	cilium assembly (GO:0042384)	2.36099105
95	regulation of sarcomere organization (GO:0060297)	2.34121138
96	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.33451931
97	protein localization to Golgi apparatus (GO:0034067)	2.33206330
98	positive regulation of fatty acid oxidation (GO:0046321)	2.32884324
99	histone mRNA catabolic process (GO:0071044)	2.31414820
100	nucleus localization (GO:0051647)	2.31015485

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.91817043
2	VDR_22108803_ChIP-Seq_LS180_Human	3.41385786
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.28615541
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.27976222
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.75007642
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.73276879
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.51185411
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.40551700
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.37127754
10	EWS_26573619_Chip-Seq_HEK293_Human	2.21881396
11	FUS_26573619_Chip-Seq_HEK293_Human	2.20739661
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.18619947
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.17601889
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.12449933
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.11115597
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.05531719
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.02319045
18	IGF1R_20145208_ChIP-Seq_DFB_Human	1.97548822
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97338761
20	P300_19829295_ChIP-Seq_ESCs_Human	1.97219094
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.96321888
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.92519927
23	STAT3_23295773_ChIP-Seq_U87_Human	1.83615206
24	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.81043646
25	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.81043646
26	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.74917053
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.74258964
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.71972320
29	AR_21572438_ChIP-Seq_LNCaP_Human	1.70129981
30	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.67662515
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.64800292
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.60038965
33	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.59875183
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58770036
35	* TCF4_23295773_ChIP-Seq_U87_Human	1.58736298
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.58718470
37	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.56865520
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.56269726
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52539208
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.51516599
41	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.49969775
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47451843
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46886024
44	AR_25329375_ChIP-Seq_VCAP_Human	1.45847206
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.44979112
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.42518058
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42518058
48	TP53_16413492_ChIP-PET_HCT116_Human	1.38216297
49	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.37883749
50	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35966260
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33666754
52	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31410940
53	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.30318814
54	AHR_22903824_ChIP-Seq_MCF-7_Human	1.28962362
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.27837076
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.26461873
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25896400
58	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.23497747
59	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.19502613
60	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19392724
61	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18028168
62	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.17892199
63	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.17831727
64	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15464359
65	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14316214
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13685598
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13657031
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13430232
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12701185
70	TP53_22573176_ChIP-Seq_HFKS_Human	1.12109703
71	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.12056746
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11388319
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10175628
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10175628
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.09582888
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09107744
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07081664
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06689680
79	CDX2_22108803_ChIP-Seq_LS180_Human	1.06589469
80	DROSHA_22980978_ChIP-Seq_HELA_Human	1.06588537
81	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.06326590
82	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.04861273
83	REST_21632747_ChIP-Seq_MESCs_Mouse	1.04297615
84	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.04215786
85	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.03606962
86	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.03488944
87	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03021656
88	* MYC_18940864_ChIP-ChIP_HL60_Human	1.03012148
89	RXR_22108803_ChIP-Seq_LS180_Human	1.02471288
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02197841
91	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01381937
92	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01219503
93	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00980614
94	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00980614
95	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.99340252
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99015772
97	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.98550522
98	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96778455
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96231365
100	KDM2B_26808549_Chip-Seq_REH_Human	0.96179435

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.38448203
2	MP0008057_abnormal_DNA_replication	2.95340460
3	MP0008877_abnormal_DNA_methylation	2.76342246
4	MP0003195_calcinosis	2.63723832
5	MP0003890_abnormal_embryonic-extraembry	2.59379337
6	MP0004043_abnormal_pH_regulation	2.50094789
7	MP0003136_yellow_coat_color	2.41238229
8	MP0002102_abnormal_ear_morphology	2.38897895
9	MP0004133_heterotaxia	2.15902867
10	MP0003646_muscle_fatigue	2.11280324
11	MP0000383_abnormal_hair_follicle	2.05074637
12	MP0000427_abnormal_hair_cycle	2.02879747
13	MP0001485_abnormal_pinna_reflex	1.90535550
14	MP0006292_abnormal_olfactory_placode	1.86187786
15	MP0005551_abnormal_eye_electrophysiolog	1.84758769
16	MP0005174_abnormal_tail_pigmentation	1.80628206
17	MP0001968_abnormal_touch/_nociception	1.74483648
18	MP0008872_abnormal_physiological_respon	1.73006445
19	MP0003787_abnormal_imprinting	1.71425166
20	MP0003937_abnormal_limbs/digits/tail_de	1.69665603
21	MP0002938_white_spotting	1.69511346
22	MP0002638_abnormal_pupillary_reflex	1.66437137
23	MP0003119_abnormal_digestive_system	1.63623455
24	MP0008961_abnormal_basal_metabolism	1.55942427
25	MP0002928_abnormal_bile_duct	1.53890355
26	MP0000631_abnormal_neuroendocrine_gland	1.52469303
27	MP0005187_abnormal_penis_morphology	1.48770887
28	MP0009046_muscle_twitch	1.47780006
29	MP0001986_abnormal_taste_sensitivity	1.41903174
30	MP0002009_preneoplasia	1.39216788
31	MP0008995_early_reproductive_senescence	1.35603915
32	MP0001486_abnormal_startle_reflex	1.34714239
33	MP0002736_abnormal_nociception_after	1.34489574
34	MP0006072_abnormal_retinal_apoptosis	1.32969076
35	MP0004142_abnormal_muscle_tone	1.32914561
36	MP0001188_hyperpigmentation	1.26512601
37	MP0005253_abnormal_eye_physiology	1.24948759
38	MP0002876_abnormal_thyroid_physiology	1.24364759
39	MP0008875_abnormal_xenobiotic_pharmacok	1.20489609
40	MP0005646_abnormal_pituitary_gland	1.19141259
41	MP0002751_abnormal_autonomic_nervous	1.18237705
42	MP0003252_abnormal_bile_duct	1.15378133
43	MP0004885_abnormal_endolymph	1.13864660
44	MP0009745_abnormal_behavioral_response	1.13637796
45	MP0000647_abnormal_sebaceous_gland	1.09002878
46	MP0002234_abnormal_pharynx_morphology	1.08235999
47	MP0010678_abnormal_skin_adnexa	1.08160808
48	MP0001293_anophthalmia	1.06785913
49	MP0004130_abnormal_muscle_cell	1.06711557
50	MP0003943_abnormal_hepatobiliary_system	1.05229077
51	MP0000778_abnormal_nervous_system	1.04488123
52	MP0005645_abnormal_hypothalamus_physiol	1.03715348
53	MP0005171_absent_coat_pigmentation	1.03376452
54	MP0003283_abnormal_digestive_organ	1.03200540
55	MP0002160_abnormal_reproductive_system	1.03190601
56	MP0005389_reproductive_system_phenotype	1.02973444
57	MP0001286_abnormal_eye_development	1.02655204
58	MP0003718_maternal_effect	1.02639001
59	MP0002557_abnormal_social/conspecific_i	0.99241182
60	MP0000538_abnormal_urinary_bladder	0.98994554
61	MP0004924_abnormal_behavior	0.98394488
62	MP0005386_behavior/neurological_phenoty	0.98394488
63	MP0004742_abnormal_vestibular_system	0.96981543
64	MP0004145_abnormal_muscle_electrophysio	0.95980154
65	MP0003567_abnormal_fetal_cardiomyocyte	0.95204889
66	MP0002272_abnormal_nervous_system	0.95046535
67	MP0001919_abnormal_reproductive_system	0.94564901
68	MP0004147_increased_porphyrin_level	0.93275597
69	MP0001501_abnormal_sleep_pattern	0.92286533
70	MP0003878_abnormal_ear_physiology	0.92119879
71	MP0005377_hearing/vestibular/ear_phenot	0.92119879
72	MP0008058_abnormal_DNA_repair	0.91160452
73	MP0002067_abnormal_sensory_capabilities	0.87581776
74	MP0006276_abnormal_autonomic_nervous	0.84075160
75	MP0003121_genomic_imprinting	0.83622332
76	MP0003698_abnormal_male_reproductive	0.83033544
77	MP0005448_abnormal_energy_balance	0.82452900
78	MP0005195_abnormal_posterior_eye	0.82443272
79	MP0005367_renal/urinary_system_phenotyp	0.82391457
80	MP0000516_abnormal_urinary_system	0.82391457
81	MP0005085_abnormal_gallbladder_physiolo	0.81264499
82	MP0002752_abnormal_somatic_nervous	0.80053255
83	MP0005310_abnormal_salivary_gland	0.79923247
84	MP0001324_abnormal_eye_pigmentation	0.79524783
85	MP0000470_abnormal_stomach_morphology	0.78862291
86	MP0002254_reproductive_system_inflammat	0.78652969
87	MP0002837_dystrophic_cardiac_calcinosis	0.78200190
88	MP0003938_abnormal_ear_development	0.77946927
89	MP0002184_abnormal_innervation	0.76265308
90	MP0005083_abnormal_biliary_tract	0.75567892
91	MP0003861_abnormal_nervous_system	0.75347488
92	MP0010094_abnormal_chromosome_stability	0.75149859
93	MP0001929_abnormal_gametogenesis	0.74917951
94	MP0003137_abnormal_impulse_conducting	0.74638915
95	MP0002095_abnormal_skin_pigmentation	0.73104938
96	MP0001873_stomach_inflammation	0.73084026
97	MP0003935_abnormal_craniofacial_develop	0.72631345
98	MP0002735_abnormal_chemical_nociception	0.71793377
99	MP0002210_abnormal_sex_determination	0.71776015
100	MP0000566_synostosis	0.70120966

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.33728269
2	Genetic anticipation (HP:0003743)	4.11344635
3	Pancreatic fibrosis (HP:0100732)	3.58069434
4	True hermaphroditism (HP:0010459)	3.46540217
5	Hyperventilation (HP:0002883)	3.45776923
6	Abnormality of midbrain morphology (HP:0002418)	3.29134645
7	Molar tooth sign on MRI (HP:0002419)	3.29134645
8	Abnormality of the renal cortex (HP:0011035)	3.27710551
9	Chronic hepatic failure (HP:0100626)	3.20572366
10	Progressive cerebellar ataxia (HP:0002073)	3.19680858
11	Nephronophthisis (HP:0000090)	3.19077117
12	Abnormality of the renal medulla (HP:0100957)	3.09700535
13	Gaze-evoked nystagmus (HP:0000640)	3.00116329
14	Protruding tongue (HP:0010808)	2.85195499
15	Tubular atrophy (HP:0000092)	2.77972514
16	Cystic liver disease (HP:0006706)	2.77964049
17	Congenital stationary night blindness (HP:0007642)	2.74295153
18	Progressive inability to walk (HP:0002505)	2.63545965
19	Large for gestational age (HP:0001520)	2.60406315
20	Birth length less than 3rd percentile (HP:0003561)	2.52439666
21	Patellar aplasia (HP:0006443)	2.51888324
22	Inability to walk (HP:0002540)	2.46933857
23	Type II lissencephaly (HP:0007260)	2.46209653
24	Broad-based gait (HP:0002136)	2.37340130
25	Clumsiness (HP:0002312)	2.33359913
26	Aplasia/Hypoplasia of the patella (HP:0006498)	2.30509897
27	Ectopic kidney (HP:0000086)	2.29576785
28	Medial flaring of the eyebrow (HP:0010747)	2.27874822
29	Hypoplasia of the pons (HP:0012110)	2.25224224
30	Abnormality of the pons (HP:0007361)	2.22001559
31	Pendular nystagmus (HP:0012043)	2.20565471
32	Renal cortical cysts (HP:0000803)	2.18493312
33	Attenuation of retinal blood vessels (HP:0007843)	2.17599343
34	Cerebellar dysplasia (HP:0007033)	2.15758196
35	Fair hair (HP:0002286)	2.15173555
36	Abnormality of alanine metabolism (HP:0010916)	2.14399301
37	Hyperalaninemia (HP:0003348)	2.14399301
38	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.14399301
39	Decreased circulating renin level (HP:0003351)	2.13670020
40	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.12909665
41	Stomach cancer (HP:0012126)	2.11842541
42	Furrowed tongue (HP:0000221)	2.09263829
43	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.09171528
44	Absent speech (HP:0001344)	2.08650828
45	Depressed nasal tip (HP:0000437)	2.08337322
46	Lissencephaly (HP:0001339)	2.05254178
47	Abnormal biliary tract physiology (HP:0012439)	2.03047319
48	Bile duct proliferation (HP:0001408)	2.03047319
49	Partial agenesis of the corpus callosum (HP:0001338)	2.02869368
50	Duplicated collecting system (HP:0000081)	2.01024311
51	Hypoplastic ischia (HP:0003175)	2.00736259
52	Hypoplastic labia majora (HP:0000059)	1.99942320
53	Chorioretinal atrophy (HP:0000533)	1.98887033
54	Congenital hepatic fibrosis (HP:0002612)	1.97082423
55	Anencephaly (HP:0002323)	1.96977635
56	Small hand (HP:0200055)	1.96242115
57	Abnormality of the nasal septum (HP:0000419)	1.96165522
58	Clubbing of toes (HP:0100760)	1.95258200
59	Abnormal pancreas size (HP:0012094)	1.92895316
60	Abnormal drinking behavior (HP:0030082)	1.92112254
61	Polydipsia (HP:0001959)	1.92112254
62	Abolished electroretinogram (ERG) (HP:0000550)	1.91128185
63	Abnormality of the renal collecting system (HP:0004742)	1.90175733
64	Intestinal atresia (HP:0011100)	1.89595230
65	Poor coordination (HP:0002370)	1.89410263
66	Abnormality of the labia majora (HP:0012881)	1.89006503
67	Congenital, generalized hypertrichosis (HP:0004540)	1.86133224
68	Abnormality of the ileum (HP:0001549)	1.85345236
69	Keratoconus (HP:0000563)	1.85077941
70	Increased corneal curvature (HP:0100692)	1.85077941
71	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.84560721
72	Abnormality of the ischium (HP:0003174)	1.84129246
73	Bilateral microphthalmos (HP:0007633)	1.84005674
74	Febrile seizures (HP:0002373)	1.83334565
75	Genital tract atresia (HP:0001827)	1.82335156
76	Cupped ear (HP:0000378)	1.82293312
77	Dandy-Walker malformation (HP:0001305)	1.82209058
78	Gait imbalance (HP:0002141)	1.82108201
79	Meckel diverticulum (HP:0002245)	1.81792742
80	Sclerocornea (HP:0000647)	1.81053793
81	Concave nail (HP:0001598)	1.81015976
82	Vaginal atresia (HP:0000148)	1.80651143
83	Highly arched eyebrow (HP:0002553)	1.80591015
84	Generalized hypopigmentation of hair (HP:0011358)	1.79865321
85	Widely spaced teeth (HP:0000687)	1.79524163
86	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.77741159
87	Tubulointerstitial nephritis (HP:0001970)	1.77635374
88	Congenital primary aphakia (HP:0007707)	1.77597071
89	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.76862328
90	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.76087571
91	Congenital sensorineural hearing impairment (HP:0008527)	1.75869201
92	Sloping forehead (HP:0000340)	1.73727177
93	Volvulus (HP:0002580)	1.72835992
94	Abnormality of chromosome stability (HP:0003220)	1.72387209
95	Optic nerve hypoplasia (HP:0000609)	1.70485641
96	Chromsome breakage (HP:0040012)	1.69729949
97	Colon cancer (HP:0003003)	1.69264035
98	Preaxial foot polydactyly (HP:0001841)	1.68433133
99	Tented upper lip vermilion (HP:0010804)	1.68148851
100	Hypoplastic iliac wings (HP:0002866)	1.66509337

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.15305375
2	ACVR1B	3.29480879
3	INSRR	3.26459241
4	BMPR1B	2.87201327
5	ADRBK2	2.42661949
6	MKNK2	2.37501831
7	WNK4	2.31908754
8	NUAK1	2.27432116
9	TLK1	2.22821555
10	TNIK	2.18991823
11	WNK3	2.18727005
12	ZAK	2.06044567
13	AKT3	1.98208732
14	CASK	1.88095633
15	BRSK2	1.87507078
16	GRK1	1.85012866
17	MAP3K4	1.75790016
18	STK39	1.65957153
19	OXSR1	1.45730813
20	PINK1	1.43261072
21	CAMK1D	1.37472343
22	MAPK13	1.36875072
23	PIK3CA	1.33796166
24	PAK3	1.27921282
25	CAMK1G	1.26767446
26	FGFR2	1.20956938
27	MAP4K2	1.20345130
28	NEK2	1.18753509
29	STK38L	1.17026415
30	TGFBR1	1.16105322
31	NLK	1.14082213
32	MARK1	1.13632558
33	TAOK3	1.12740335
34	MKNK1	1.12026049
35	BRD4	1.08887303
36	PNCK	1.03176534
37	ADRBK1	0.98031697
38	SGK2	0.97954735
39	WEE1	0.92326395
40	WNK1	0.83587812
41	DAPK2	0.81225066
42	MAP3K7	0.80809680
43	ERBB2	0.75079335
44	PRKAA2	0.74287348
45	TRIM28	0.74205615
46	CHUK	0.72510999
47	MELK	0.72174244
48	PRKAA1	0.68823575
49	PRKCE	0.68170536
50	MAPK15	0.68130471
51	LATS1	0.66418111
52	STK3	0.66403370
53	SIK2	0.65997803
54	STK11	0.64355343
55	PLK4	0.63142819
56	NTRK3	0.62533101
57	MAP2K7	0.62385008
58	ATR	0.61010182
59	PRKCG	0.58033044
60	CDC7	0.56416916
61	PTK2B	0.55096078
62	TAF1	0.54929553
63	IRAK1	0.53661392
64	MAPKAPK5	0.51337583
65	SGK223	0.50730456
66	SGK494	0.50730456
67	CDK12	0.49827015
68	CAMKK2	0.48916245
69	FLT3	0.48705898
70	MUSK	0.48693833
71	NTRK2	0.48070792
72	NME1	0.47694672
73	TEC	0.46213523
74	ERBB3	0.46085569
75	CHEK2	0.45528639
76	TRPM7	0.45519432
77	FER	0.45213512
78	ATM	0.44086131
79	PIK3CG	0.43850158
80	EPHA3	0.41149750
81	TNK2	0.37831077
82	CSNK1D	0.35241585
83	CSNK1A1L	0.35062203
84	MAP2K6	0.34605527
85	MAP2K4	0.34342290
86	PLK2	0.33514113
87	CAMK4	0.32596027
88	VRK1	0.32235483
89	FGFR1	0.31857403
90	BCR	0.31695937
91	CAMK1	0.31266163
92	CSNK1A1	0.30968530
93	PLK3	0.30736916
94	MAP2K1	0.30336847
95	MAPK8	0.30105027
96	OBSCN	0.30031909
97	PDGFRB	0.29921235
98	DYRK2	0.29920456
99	CDK3	0.29260678
100	TXK	0.28860238

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	2.50543647
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.42603543
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.41560199
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.35729305
5	Phototransduction_Homo sapiens_hsa04744	2.25510812
6	Butanoate metabolism_Homo sapiens_hsa00650	2.23040668
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.20245496
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.18379750
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.13815182
10	Homologous recombination_Homo sapiens_hsa03440	2.08291859
11	Nicotine addiction_Homo sapiens_hsa05033	2.03976883
12	Caffeine metabolism_Homo sapiens_hsa00232	2.01947882
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.98386334
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.94253147
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.93654023
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.92308110
17	ABC transporters_Homo sapiens_hsa02010	1.91780080
18	Lysine degradation_Homo sapiens_hsa00310	1.82543676
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.77490949
20	Basal transcription factors_Homo sapiens_hsa03022	1.76848833
21	Taste transduction_Homo sapiens_hsa04742	1.76585140
22	RNA polymerase_Homo sapiens_hsa03020	1.65788188
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64604731
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.62545399
25	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.53558889
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.39173637
27	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.32293854
28	Propanoate metabolism_Homo sapiens_hsa00640	1.27640077
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.25177446
30	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.24511831
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.18903516
32	RNA degradation_Homo sapiens_hsa03018	1.17919752
33	Olfactory transduction_Homo sapiens_hsa04740	1.16798024
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.16677852
35	Non-homologous end-joining_Homo sapiens_hsa03450	1.16119803
36	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.12309984
37	Insulin secretion_Homo sapiens_hsa04911	1.12240183
38	Morphine addiction_Homo sapiens_hsa05032	1.10662641
39	Basal cell carcinoma_Homo sapiens_hsa05217	1.09331601
40	Glycerolipid metabolism_Homo sapiens_hsa00561	1.07955852
41	Glutamatergic synapse_Homo sapiens_hsa04724	1.07930841
42	One carbon pool by folate_Homo sapiens_hsa00670	1.07155639
43	Circadian entrainment_Homo sapiens_hsa04713	1.04518405
44	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.02651390
45	Circadian rhythm_Homo sapiens_hsa04710	1.02095026
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01718339
47	Serotonergic synapse_Homo sapiens_hsa04726	1.01647572
48	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.01239087
49	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.98896460
50	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.96197861
51	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.96040618
52	Histidine metabolism_Homo sapiens_hsa00340	0.91340865
53	Calcium signaling pathway_Homo sapiens_hsa04020	0.86495974
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.85353251
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83745296
56	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.83289989
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82703596
58	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.80909754
59	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.80398043
60	Retinol metabolism_Homo sapiens_hsa00830	0.77874834
61	Hippo signaling pathway_Homo sapiens_hsa04390	0.75321604
62	GABAergic synapse_Homo sapiens_hsa04727	0.75286526
63	Cholinergic synapse_Homo sapiens_hsa04725	0.74133863
64	Type II diabetes mellitus_Homo sapiens_hsa04930	0.73254574
65	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.71549928
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.71058924
67	Peroxisome_Homo sapiens_hsa04146	0.71055293
68	Salivary secretion_Homo sapiens_hsa04970	0.69368332
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.65488422
70	cAMP signaling pathway_Homo sapiens_hsa04024	0.63806830
71	Dopaminergic synapse_Homo sapiens_hsa04728	0.59891749
72	Protein export_Homo sapiens_hsa03060	0.57516386
73	FoxO signaling pathway_Homo sapiens_hsa04068	0.55157265
74	Long-term depression_Homo sapiens_hsa04730	0.54855006
75	Mineral absorption_Homo sapiens_hsa04978	0.54089948
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50895926
77	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.49941993
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47379789
79	Cocaine addiction_Homo sapiens_hsa05030	0.46327967
80	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.45611930
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44345967
82	Axon guidance_Homo sapiens_hsa04360	0.42747784
83	Wnt signaling pathway_Homo sapiens_hsa04310	0.42459038
84	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.42021684
85	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41530297
86	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.40614448
87	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.39796009
88	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.39727640
89	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.38907063
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38874544
91	Gastric acid secretion_Homo sapiens_hsa04971	0.38151840
92	Renin secretion_Homo sapiens_hsa04924	0.38147975
93	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.36554380
94	p53 signaling pathway_Homo sapiens_hsa04115	0.36287673
95	Amphetamine addiction_Homo sapiens_hsa05031	0.36208133
96	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.35656909
97	Insulin resistance_Homo sapiens_hsa04931	0.35421998
98	Bile secretion_Homo sapiens_hsa04976	0.35236108
99	RNA transport_Homo sapiens_hsa03013	0.34863358
100	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.34390141

ZNF587

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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