ZNF587P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033398.69147111
2regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)7.99440181
3negative regulation of metanephros development (GO:0072217)7.86031294
4iron coordination entity transport (GO:1901678)7.27348257
5positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)6.76947878
6regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)6.76947878
7regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)5.57808787
8regulation of mitotic spindle checkpoint (GO:1903504)5.57808787
9regulation of interleukin-12 biosynthetic process (GO:0045075)5.35307260
10regulation of vitamin D biosynthetic process (GO:0060556)4.91581985
11regulation of podosome assembly (GO:0071801)4.89613774
12regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)4.75494714
13positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.73379948
14regulation of isotype switching to IgG isotypes (GO:0048302)4.67189355
15regulation of posttranscriptional gene silencing (GO:0060147)4.50105320
16regulation of gene silencing by miRNA (GO:0060964)4.50105320
17regulation of gene silencing by RNA (GO:0060966)4.50105320
18positive regulation of chemokine biosynthetic process (GO:0045080)4.43949674
19defense response to protozoan (GO:0042832)4.40369083
20regulation of gastrulation (GO:0010470)4.38297397
21presynaptic membrane assembly (GO:0097105)4.31040498
22calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.17452130
23magnesium ion transport (GO:0015693)4.07776310
24L-serine metabolic process (GO:0006563)4.07292670
25negative regulation of kidney development (GO:0090185)4.07063215
26regulation of chemokine biosynthetic process (GO:0045073)4.02891433
27regulation of vitamin metabolic process (GO:0030656)3.98426648
28regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.95446163
29vocalization behavior (GO:0071625)3.94130454
30anterior/posterior axis specification, embryo (GO:0008595)3.90911333
31response to protozoan (GO:0001562)3.82233189
32protein K6-linked ubiquitination (GO:0085020)3.75398321
33organelle disassembly (GO:1903008)3.72073987
34regulation of MHC class II biosynthetic process (GO:0045346)3.65808192
35regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.60268558
36platelet dense granule organization (GO:0060155)3.60055605
37water-soluble vitamin biosynthetic process (GO:0042364)3.58723591
38serine family amino acid biosynthetic process (GO:0009070)3.57594718
39ovulation from ovarian follicle (GO:0001542)3.55131045
40negative regulation of DNA-dependent DNA replication (GO:2000104)3.51418186
41regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.46696478
42otic vesicle formation (GO:0030916)3.46642026
43positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.44255607
44leukocyte apoptotic process (GO:0071887)3.43941244
45regulation of heterotypic cell-cell adhesion (GO:0034114)3.37531356
46regulation of metanephros development (GO:0072215)3.35707331
47mitotic metaphase plate congression (GO:0007080)3.33400043
48regulation of cell fate specification (GO:0042659)3.32596379
49neuromuscular process controlling posture (GO:0050884)3.30571297
50regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.29784193
51presynaptic membrane organization (GO:0097090)3.28670921
52folic acid metabolic process (GO:0046655)3.27746020
53regulation of collateral sprouting (GO:0048670)3.26634468
54glycine metabolic process (GO:0006544)3.19388915
55negative regulation of neurological system process (GO:0031645)3.18975130
56positive regulation of muscle cell apoptotic process (GO:0010661)3.18543549
57zinc ion transmembrane transport (GO:0071577)3.18078002
58intra-S DNA damage checkpoint (GO:0031573)3.17936638
59negative regulation of interleukin-17 production (GO:0032700)3.17700155
60protein import into nucleus, translocation (GO:0000060)3.16344240
61positive regulation of isotype switching (GO:0045830)3.13725656
62DNA replication checkpoint (GO:0000076)3.13454804
63metaphase plate congression (GO:0051310)3.12712003
64regulation of nuclear cell cycle DNA replication (GO:0033262)3.12248673
65regulation of cell fate commitment (GO:0010453)3.10636261
66regulation of regulatory T cell differentiation (GO:0045589)3.06156323
67organ growth (GO:0035265)3.05681839
68protein localization to kinetochore (GO:0034501)3.05583098
69regulation of spindle checkpoint (GO:0090231)3.03885072
70regulation of interleukin-6 biosynthetic process (GO:0045408)3.01092740
71positive regulation of steroid biosynthetic process (GO:0010893)3.00947852
72male meiosis (GO:0007140)2.93654546
73mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89511689
74regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.89489744
75ATP synthesis coupled proton transport (GO:0015986)2.89035458
76energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89035458
77regulation of stem cell maintenance (GO:2000036)2.88514763
78cell-cell junction maintenance (GO:0045217)2.88238726
79tetrahydrofolate metabolic process (GO:0046653)2.86096803
80negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.81991918
81positive regulation of osteoclast differentiation (GO:0045672)2.81955600
82serine family amino acid catabolic process (GO:0009071)2.81514158
83branching involved in salivary gland morphogenesis (GO:0060445)2.81143324
84purine nucleobase biosynthetic process (GO:0009113)2.75818956
85maturation of 5.8S rRNA (GO:0000460)2.72237140
86positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.71128193
87negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.69752012
88negative regulation of translation, ncRNA-mediated (GO:0040033)2.69752012
89regulation of translation, ncRNA-mediated (GO:0045974)2.69752012
90positive regulation of DNA recombination (GO:0045911)2.67348410
91negative regulation of cell fate specification (GO:0009996)2.66730225
92mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.66517189
93establishment of endothelial barrier (GO:0061028)2.66384568
94negative regulation of cardiac muscle tissue development (GO:0055026)2.64429892
95T cell differentiation involved in immune response (GO:0002292)2.64101881
96alpha-beta T cell differentiation involved in immune response (GO:0002293)2.64101881
97alpha-beta T cell activation involved in immune response (GO:0002287)2.64101881
98regulation of smooth muscle cell apoptotic process (GO:0034391)2.63153623
99ncRNA catabolic process (GO:0034661)2.62761281
100prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.62495699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_15608294_ChIP-ChIP_MCF-7_Human5.65172177
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.03307855
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.88683817
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.72637878
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23378580
6VDR_22108803_ChIP-Seq_LS180_Human2.97074941
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.91488471
8E2F7_22180533_ChIP-Seq_HELA_Human2.79622241
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.79094334
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57635945
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53709504
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.51783105
13ZNF274_21170338_ChIP-Seq_K562_Hela2.49177974
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42681721
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.34943685
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30688070
17ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.16553395
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10231915
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.93850908
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93779105
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.89125097
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87998953
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.85579483
24POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.84267960
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.83742787
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82125324
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79323957
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.78036382
29GATA1_22025678_ChIP-Seq_K562_Human1.72843793
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72623360
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65328917
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62738230
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.60602460
34NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.56868211
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.55829294
36EWS_26573619_Chip-Seq_HEK293_Human1.50427838
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46408512
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45987757
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45871246
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45871246
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45871246
42MYC_18940864_ChIP-ChIP_HL60_Human1.44376654
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41064224
44ELK1_19687146_ChIP-ChIP_HELA_Human1.39953103
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.38489705
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38231384
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35740304
48SOX2_16153702_ChIP-ChIP_HESCs_Human1.33941531
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.26507246
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23751766
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22447354
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22329512
53LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21998549
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.21827040
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21371737
56VDR_23849224_ChIP-Seq_CD4+_Human1.20897443
57TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20878296
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17435944
59TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15499018
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13760715
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.13201150
62FOXP3_21729870_ChIP-Seq_TREG_Human1.12353081
63ER_23166858_ChIP-Seq_MCF-7_Human1.10521400
64LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10113404
65P300_19829295_ChIP-Seq_ESCs_Human1.08657028
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06644493
67KAP1_22055183_ChIP-Seq_ESCs_Mouse1.04613095
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04418298
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03790909
70MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93855087
71TP53_16413492_ChIP-PET_HCT116_Human0.93129517
72BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92932814
73ELK1_22589737_ChIP-Seq_MCF10A_Human0.92132334
74ETV1_20927104_ChIP-Seq_GIST48_Human0.91248747
75NFE2_27457419_Chip-Seq_LIVER_Mouse0.90595742
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90315216
77NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89964168
78TCF4_22108803_ChIP-Seq_LS180_Human0.89764351
79EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89001365
80CEBPB_22108803_ChIP-Seq_LS180_Human0.88922177
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87365779
82SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85437888
83EZH2_27294783_Chip-Seq_NPCs_Mouse0.84692248
84ESR1_21235772_ChIP-Seq_MCF-7_Human0.84002951
85GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83017112
86NANOG_20526341_ChIP-Seq_ESCs_Human0.82845014
87GATA6_21074721_ChIP-Seq_CACO-2_Human0.82260903
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.82000507
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.81690831
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81018243
91SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80947339
92HOXB7_26014856_ChIP-Seq_BT474_Human0.80594283
93E2F1_21310950_ChIP-Seq_MCF-7_Human0.79614717
94RBPJ_21746931_ChIP-Seq_IB4_Human0.79454415
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.79064298
96FOXA1_25329375_ChIP-Seq_VCAP_Human0.77283892
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77283892
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.75492660
99DCP1A_22483619_ChIP-Seq_HELA_Human0.75126724
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.74966084

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development5.53420297
2MP0001873_stomach_inflammation4.76994323
3MP0002254_reproductive_system_inflammat4.52129267
4MP0010307_abnormal_tumor_latency3.53377765
5MP0004019_abnormal_vitamin_homeostasis2.99834780
6MP0004782_abnormal_surfactant_physiolog2.82771355
7MP0005503_abnormal_tendon_morphology2.73351482
8MP0001881_abnormal_mammary_gland2.64107160
9MP0005084_abnormal_gallbladder_morpholo2.52887847
10MP0003693_abnormal_embryo_hatching2.52133135
11MP0009333_abnormal_splenocyte_physiolog2.38676401
12MP0003718_maternal_effect2.32319910
13MP0000579_abnormal_nail_morphology2.31689507
14MP0003646_muscle_fatigue2.28688841
15MP0006292_abnormal_olfactory_placode2.26936023
16MP0003011_delayed_dark_adaptation2.26782279
17MP0003329_amyloid_beta_deposits2.25050657
18MP0008877_abnormal_DNA_methylation2.17659222
19MP0008058_abnormal_DNA_repair2.11344858
20MP0003950_abnormal_plasma_membrane2.06897741
21MP0003183_abnormal_peptide_metabolism2.02943001
22MP0000467_abnormal_esophagus_morphology2.00340867
23MP0000569_abnormal_digit_pigmentation1.96487169
24MP0005645_abnormal_hypothalamus_physiol1.95854257
25MP0001188_hyperpigmentation1.86818373
26MP0002928_abnormal_bile_duct1.76358671
27MP0003195_calcinosis1.75455277
28MP0010094_abnormal_chromosome_stability1.72715075
29MP0000049_abnormal_middle_ear1.58129448
30MP0003936_abnormal_reproductive_system1.56414866
31MP0002405_respiratory_system_inflammati1.51366153
32MP0001835_abnormal_antigen_presentation1.48901869
33MP0001663_abnormal_digestive_system1.46451808
34MP0009785_altered_susceptibility_to1.46390057
35MP0003186_abnormal_redox_activity1.35441338
36MP0000627_abnormal_mammary_gland1.29808071
37MP0002277_abnormal_respiratory_mucosa1.25946459
38MP0000762_abnormal_tongue_morphology1.22274828
39MP0005332_abnormal_amino_acid1.21583817
40MP0000678_abnormal_parathyroid_gland1.20495494
41MP0001501_abnormal_sleep_pattern1.20436016
42MP0004185_abnormal_adipocyte_glucose1.19962509
43MP0004957_abnormal_blastocyst_morpholog1.19762934
44MP0003806_abnormal_nucleotide_metabolis1.18907934
45MP0000566_synostosis1.18877700
46MP0005381_digestive/alimentary_phenotyp1.16847677
47MP0000749_muscle_degeneration1.13612731
48MP0002796_impaired_skin_barrier1.11332285
49MP0001293_anophthalmia1.10607991
50MP0005501_abnormal_skin_physiology1.08659579
51MP0002111_abnormal_tail_morphology1.05039565
52MP0000604_amyloidosis1.04083174
53MP0000631_abnormal_neuroendocrine_gland1.03358510
54MP0002876_abnormal_thyroid_physiology1.03215870
55MP0001958_emphysema1.03196429
56MP0003638_abnormal_response/metabolism_1.02555373
57MP0003699_abnormal_female_reproductive1.02528854
58MP0002160_abnormal_reproductive_system1.02361121
59MP0005671_abnormal_response_to1.01691611
60MP0002177_abnormal_outer_ear0.97171989
61MP0002909_abnormal_adrenal_gland0.96958271
62MP0005551_abnormal_eye_electrophysiolog0.93623566
63MP0008872_abnormal_physiological_respon0.91142223
64MP0005508_abnormal_skeleton_morphology0.85302411
65MP0004272_abnormal_basement_membrane0.84712565
66MP0000013_abnormal_adipose_tissue0.83879953
67MP0002210_abnormal_sex_determination0.83338625
68MP0003937_abnormal_limbs/digits/tail_de0.80978322
69MP0008770_decreased_survivor_rate0.79776049
70MP0002295_abnormal_pulmonary_circulatio0.78341088
71MP0005389_reproductive_system_phenotype0.78335811
72MP0002136_abnormal_kidney_physiology0.77747938
73MP0001119_abnormal_female_reproductive0.76959401
74MP0002933_joint_inflammation0.76121986
75MP0003938_abnormal_ear_development0.74912005
76MP0010678_abnormal_skin_adnexa0.71771050
77MP0002127_abnormal_cardiovascular_syste0.71748838
78MP0003119_abnormal_digestive_system0.71484638
79MP0005083_abnormal_biliary_tract0.71010200
80MP0009780_abnormal_chondrocyte_physiolo0.68023637
81MP0003828_pulmonary_edema0.67477610
82MP0002697_abnormal_eye_size0.65463730
83MP0003943_abnormal_hepatobiliary_system0.64881353
84MP0005636_abnormal_mineral_homeostasis0.63527836
85MP0000470_abnormal_stomach_morphology0.63190656
86MP0000685_abnormal_immune_system0.63108946
87MP0001286_abnormal_eye_development0.62347737
88MP0002108_abnormal_muscle_morphology0.60972678
89MP0005174_abnormal_tail_pigmentation0.60867543
90MP0001299_abnormal_eye_distance/0.60556880
91MP0003077_abnormal_cell_cycle0.59974859
92MP0000383_abnormal_hair_follicle0.58494651
93MP0003448_altered_tumor_morphology0.58325721
94MP0004197_abnormal_fetal_growth/weight/0.58316830
95MP0003385_abnormal_body_wall0.58088080
96MP0000681_abnormal_thyroid_gland0.56991600
97MP0000639_abnormal_adrenal_gland0.56360042
98MP0001986_abnormal_taste_sensitivity0.55701689
99MP0010234_abnormal_vibrissa_follicle0.55160973
100MP0005319_abnormal_enzyme/_coenzyme0.54094640

Predicted human phenotypes

RankGene SetZ-score
1Hypomagnesemia (HP:0002917)5.94851589
2Tetany (HP:0001281)5.86512763
3Abnormality of magnesium homeostasis (HP:0004921)4.92418487
4Abnormality of homocysteine metabolism (HP:0010919)4.50209193
5Homocystinuria (HP:0002156)4.50209193
6Pancreatic islet-cell hyperplasia (HP:0004510)4.45016886
7Methylmalonic aciduria (HP:0012120)3.89846530
8Abnormal drinking behavior (HP:0030082)3.71826280
9Polydipsia (HP:0001959)3.71826280
10Hyperglycinuria (HP:0003108)3.53910458
11Hyperglycinemia (HP:0002154)3.43140020
12Split foot (HP:0001839)3.26321619
13Abnormality of the vertebral endplates (HP:0005106)3.22017051
14Irregular epiphyses (HP:0010582)3.14321075
15Thyroid-stimulating hormone excess (HP:0002925)3.12578359
16Hyperuricemia (HP:0002149)3.11639303
17Increased purine levels (HP:0004368)3.11639303
18Hypoglycemic seizures (HP:0002173)3.04030321
19Humeroradial synostosis (HP:0003041)2.98767290
20Synostosis involving the elbow (HP:0003938)2.98767290
21Increased hepatocellular lipid droplets (HP:0006565)2.88983143
22Septo-optic dysplasia (HP:0100842)2.87572726
23Lipid accumulation in hepatocytes (HP:0006561)2.87570658
24Hypoplasia of the pons (HP:0012110)2.83473561
25Abnormality of the pons (HP:0007361)2.78567299
26Hypoplasia of the capital femoral epiphysis (HP:0003090)2.71608567
27Confusion (HP:0001289)2.68173090
28Abnormality of glycine metabolism (HP:0010895)2.58150428
29Abnormality of serine family amino acid metabolism (HP:0010894)2.58150428
30Methylmalonic acidemia (HP:0002912)2.57996401
31Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.56201850
32Stridor (HP:0010307)2.54723188
33Esophageal atresia (HP:0002032)2.54176221
34Stomach cancer (HP:0012126)2.52939438
35Exercise-induced muscle cramps (HP:0003710)2.52024233
36Aplasia involving bones of the upper limbs (HP:0009823)2.47254773
37Aplasia of the phalanges of the hand (HP:0009802)2.47254773
38Aplasia involving bones of the extremities (HP:0009825)2.47254773
39Multifactorial inheritance (HP:0001426)2.46993261
40Broad metatarsal (HP:0001783)2.46504501
41Absent epiphyses (HP:0010577)2.46101704
42Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.46101704
43Polyuria (HP:0000103)2.43334188
44Hypoplasia of the radius (HP:0002984)2.42971967
45Impulsivity (HP:0100710)2.41708159
46Hypothermia (HP:0002045)2.41267426
47Exertional dyspnea (HP:0002875)2.39135497
48Short hallux (HP:0010109)2.35150489
49Anomalous pulmonary venous return (HP:0010772)2.34818191
50Abnormal number of erythroid precursors (HP:0012131)2.30102498
51Polygenic inheritance (HP:0010982)2.29579145
52Abnormality of the phalanges of the 2nd finger (HP:0009541)2.29045156
53Abnormality of serum amino acid levels (HP:0003112)2.26430661
54Symptomatic seizures (HP:0011145)2.26204117
55Bilateral microphthalmos (HP:0007633)2.24270348
56Abnormality of chromosome stability (HP:0003220)2.23498049
57Meckel diverticulum (HP:0002245)2.19470480
58Enlarged epiphyses (HP:0010580)2.17452345
59Aplasia/Hypoplasia of the hallux (HP:0008362)2.17239240
60Hypoplastic pelvis (HP:0008839)2.16476806
61Abnormality of the ileum (HP:0001549)2.14464118
62Diaphragmatic weakness (HP:0009113)2.10237884
63Absent septum pellucidum (HP:0001331)2.07847248
64Abnormality of endocrine pancreas physiology (HP:0012093)2.07653200
65Abnormality of the pancreatic islet cells (HP:0006476)2.07653200
66Hypoglycemic coma (HP:0001325)2.05862031
67Fibular aplasia (HP:0002990)2.04222186
68Renal tubular acidosis (HP:0001947)2.02911663
69Attenuation of retinal blood vessels (HP:0007843)2.02607969
70IgA deficiency (HP:0002720)2.01797695
71Acute necrotizing encephalopathy (HP:0006965)2.01721610
72Abnormality of the pulmonary veins (HP:0011718)1.98784904
73Irregular vertebral endplates (HP:0003301)1.97389686
74Hyperlipoproteinemia (HP:0010980)1.96911089
75Abnormality of vitamin metabolism (HP:0100508)1.95265558
76Abnormality of the epiphysis of the femoral head (HP:0010574)1.94608224
77Acute encephalopathy (HP:0006846)1.93787126
78Cutaneous finger syndactyly (HP:0010554)1.92782139
79Cerebellar dysplasia (HP:0007033)1.92614850
80Hyperinsulinemic hypoglycemia (HP:0000825)1.90368948
81Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.90169775
82Abnormality of femoral epiphyses (HP:0006499)1.90169775
83Flattened epiphyses (HP:0003071)1.89665471
84Forearm undergrowth (HP:0009821)1.86920823
85Carpal bone hypoplasia (HP:0001498)1.86800808
86Mitochondrial inheritance (HP:0001427)1.86759848
87Type II lissencephaly (HP:0007260)1.86430393
88Abnormal urine output (HP:0012590)1.86086779
89Cutaneous syndactyly (HP:0012725)1.85785249
90Lethargy (HP:0001254)1.85401506
91Abnormality of the labia minora (HP:0012880)1.85176108
92Intrahepatic cholestasis (HP:0001406)1.83719599
93Abnormality of cells of the erythroid lineage (HP:0012130)1.83169980
94Dialeptic seizures (HP:0011146)1.82741429
95Aplasia/Hypoplasia of the ulna (HP:0006495)1.81156916
96Abnormality of purine metabolism (HP:0004352)1.80246450
97Chronic otitis media (HP:0000389)1.79264394
98Abnormality of cochlea (HP:0000375)1.78877179
99Barrel-shaped chest (HP:0001552)1.78502376
100Renal Fanconi syndrome (HP:0001994)1.76784293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME14.79933752
2PBK4.63511906
3TRIB33.61859048
4BUB13.40572053
5MAP3K142.78654450
6MST42.66911891
7CDK122.52775743
8BMPR1B2.39650769
9TXK2.23341877
10FGFR22.21713683
11MAPK152.14675525
12CDC72.09010561
13STK42.00768677
14TAOK31.82863062
15MKNK21.79913707
16TNIK1.74981356
17TLK11.68117184
18PNCK1.62142094
19EIF2AK21.58023314
20WNK31.55575191
21GRK11.53500891
22NTRK21.53412957
23EPHA21.52912003
24OXSR11.48259153
25CDK191.43983492
26FGFR11.40362169
27NEK11.33966312
28PKN11.29930589
29PTK61.29386059
30TTK1.27138562
31PLK11.22639528
32CLK11.17179121
33BMX1.12702869
34ADRBK21.09412785
35PLK31.09221438
36ZAK1.08714186
37ILK1.06329906
38PAK31.01343738
39NEK20.99913552
40ACVR1B0.99069629
41FLT30.95747486
42ERN10.89499380
43CSNK1A10.88957631
44EIF2AK30.86969083
45CDK70.85113990
46CAMK10.83799718
47CSF1R0.83187077
48MKNK10.82785047
49AURKB0.80468310
50CHUK0.77977336
51ATR0.77010399
52VRK10.73215582
53STK30.70670490
54MAP3K100.69692775
55CHEK20.68364937
56PKN20.67811502
57PRKCE0.65489761
58ERBB20.64996415
59AKT30.63403006
60IGF1R0.62828877
61MAP3K70.60636563
62BRSK20.59029814
63MAP3K30.58915023
64CAMK1G0.58086267
65MAP3K90.58013099
66DMPK0.57054729
67IKBKE0.55351301
68PINK10.54611900
69STK110.54383559
70CSNK1E0.52604877
71PRKCG0.51006193
72MAPKAPK20.48655719
73CSNK2A20.47265067
74ATM0.46120360
75TEC0.44864213
76PIM10.43132924
77MYLK0.42455882
78CDK30.41048004
79PRKCQ0.40666875
80CSNK2A10.40538664
81CHEK10.40075610
82WEE10.39503518
83INSR0.39182514
84GSK3A0.39126934
85CSNK1G10.38063577
86PDK20.35981905
87PDK10.34890541
88PRKDC0.34126574
89MAP3K40.33663618
90CAMK2A0.32981903
91ERBB40.32507618
92MET0.32222476
93IKBKB0.31322991
94CAMK40.31029822
95TIE10.31022967
96CSNK1D0.30408465
97MAPK140.29099497
98CSNK1G30.27612738
99PRKACB0.27386236
100CSNK1G20.26745644

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006704.20793863
2Homologous recombination_Homo sapiens_hsa034404.00407693
3RNA polymerase_Homo sapiens_hsa030203.15968981
4Proteasome_Homo sapiens_hsa030503.12863898
5African trypanosomiasis_Homo sapiens_hsa051432.97483860
6Vitamin digestion and absorption_Homo sapiens_hsa049772.70005124
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35850879
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.21692793
9Oxidative phosphorylation_Homo sapiens_hsa001902.14121532
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.99049572
11Ribosome_Homo sapiens_hsa030101.96257971
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89515941
13Parkinsons disease_Homo sapiens_hsa050121.88042987
14Fanconi anemia pathway_Homo sapiens_hsa034601.83526467
15Selenocompound metabolism_Homo sapiens_hsa004501.82922288
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.79234556
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72792241
18Spliceosome_Homo sapiens_hsa030401.71684423
19Regulation of autophagy_Homo sapiens_hsa041401.53191827
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51759862
21Propanoate metabolism_Homo sapiens_hsa006401.48695756
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47848617
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45077504
24Folate biosynthesis_Homo sapiens_hsa007901.44801245
25Huntingtons disease_Homo sapiens_hsa050161.37064770
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28583128
27Linoleic acid metabolism_Homo sapiens_hsa005911.20802095
28Vitamin B6 metabolism_Homo sapiens_hsa007501.16996689
29Phototransduction_Homo sapiens_hsa047441.15196546
30Protein export_Homo sapiens_hsa030601.14677933
31Salivary secretion_Homo sapiens_hsa049701.14507245
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12602360
33Rheumatoid arthritis_Homo sapiens_hsa053231.12144656
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12015484
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.10565400
36Alzheimers disease_Homo sapiens_hsa050101.09702708
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08891530
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04557861
39Basal transcription factors_Homo sapiens_hsa030221.01717733
40RNA degradation_Homo sapiens_hsa030180.99248280
41Arginine biosynthesis_Homo sapiens_hsa002200.97835800
42Tight junction_Homo sapiens_hsa045300.97131867
43Purine metabolism_Homo sapiens_hsa002300.89258079
44Mismatch repair_Homo sapiens_hsa034300.88352810
45Base excision repair_Homo sapiens_hsa034100.87533043
46Non-homologous end-joining_Homo sapiens_hsa034500.86348642
47Allograft rejection_Homo sapiens_hsa053300.84693060
48Arachidonic acid metabolism_Homo sapiens_hsa005900.83948310
49Cardiac muscle contraction_Homo sapiens_hsa042600.83662374
50Pyrimidine metabolism_Homo sapiens_hsa002400.79599187
51Fat digestion and absorption_Homo sapiens_hsa049750.78214556
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78134225
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.77171565
54Retinol metabolism_Homo sapiens_hsa008300.75060560
55Fatty acid metabolism_Homo sapiens_hsa012120.74894822
56Small cell lung cancer_Homo sapiens_hsa052220.74068210
57Fatty acid degradation_Homo sapiens_hsa000710.73807273
58Graft-versus-host disease_Homo sapiens_hsa053320.73419280
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72591836
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72373125
61Pyruvate metabolism_Homo sapiens_hsa006200.71847261
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70282534
63Hepatitis C_Homo sapiens_hsa051600.66091999
64RNA transport_Homo sapiens_hsa030130.64884339
65Malaria_Homo sapiens_hsa051440.64062080
66Amoebiasis_Homo sapiens_hsa051460.62625206
67T cell receptor signaling pathway_Homo sapiens_hsa046600.62099112
68Fatty acid elongation_Homo sapiens_hsa000620.62027512
69Basal cell carcinoma_Homo sapiens_hsa052170.61845690
70DNA replication_Homo sapiens_hsa030300.61811126
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61692041
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59894680
73Taste transduction_Homo sapiens_hsa047420.59759105
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59285088
75Caffeine metabolism_Homo sapiens_hsa002320.57102646
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.56789189
77Thyroid cancer_Homo sapiens_hsa052160.56178506
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55057321
79Renin-angiotensin system_Homo sapiens_hsa046140.54973070
80Tryptophan metabolism_Homo sapiens_hsa003800.53906161
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51444430
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51390104
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51307312
84Glycerolipid metabolism_Homo sapiens_hsa005610.48021972
85Measles_Homo sapiens_hsa051620.47442530
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46758653
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45969406
88Prostate cancer_Homo sapiens_hsa052150.44541857
89TGF-beta signaling pathway_Homo sapiens_hsa043500.44152729
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.42203292
91Metabolic pathways_Homo sapiens_hsa011000.42071675
92Nitrogen metabolism_Homo sapiens_hsa009100.37297862
93Mineral absorption_Homo sapiens_hsa049780.36047388
94Wnt signaling pathway_Homo sapiens_hsa043100.36046646
95Ovarian steroidogenesis_Homo sapiens_hsa049130.34201873
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.33941482
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.33732449
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33287010
99Hematopoietic cell lineage_Homo sapiens_hsa046400.33024848
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32545828

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