ZNF589

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)6.46387217
2regulation of gene silencing by RNA (GO:0060966)6.16309754
3regulation of posttranscriptional gene silencing (GO:0060147)6.16309754
4regulation of gene silencing by miRNA (GO:0060964)6.16309754
5regulation of histone H3-K9 methylation (GO:0051570)4.90608653
6negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.89567712
7negative regulation of translation, ncRNA-mediated (GO:0040033)4.89567712
8regulation of translation, ncRNA-mediated (GO:0045974)4.89567712
9nuclear pore complex assembly (GO:0051292)4.83046714
10negative regulation of histone methylation (GO:0031061)4.55990464
11heterochromatin organization (GO:0070828)4.49171290
12nuclear pore organization (GO:0006999)4.42353043
13protein localization to kinetochore (GO:0034501)4.18970957
14somatic hypermutation of immunoglobulin genes (GO:0016446)4.01519443
15somatic diversification of immune receptors via somatic mutation (GO:0002566)4.01519443
16mitotic sister chromatid cohesion (GO:0007064)3.98842142
17establishment of integrated proviral latency (GO:0075713)3.89569018
18L-serine metabolic process (GO:0006563)3.81190075
19positive regulation of SMAD protein import into nucleus (GO:0060391)3.74015263
20IMP biosynthetic process (GO:0006188)3.71002196
21regulation of gene silencing (GO:0060968)3.62419530
22pore complex assembly (GO:0046931)3.61522823
23negative regulation of chromosome segregation (GO:0051985)3.61360495
24DNA unwinding involved in DNA replication (GO:0006268)3.61173211
25negative regulation of mitotic sister chromatid separation (GO:2000816)3.59777140
26negative regulation of sister chromatid segregation (GO:0033046)3.59777140
27negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.59777140
28negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.59777140
29negative regulation of mitotic sister chromatid segregation (GO:0033048)3.59777140
30chromatin remodeling at centromere (GO:0031055)3.59008323
31protein localization to chromosome, centromeric region (GO:0071459)3.54866835
32regulation of helicase activity (GO:0051095)3.50847927
33DNA strand elongation involved in DNA replication (GO:0006271)3.49468532
34regulation of mitotic spindle checkpoint (GO:1903504)3.49176929
35regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.49176929
36positive regulation of histone H3-K4 methylation (GO:0051571)3.46420119
37mitotic spindle checkpoint (GO:0071174)3.45260772
38ncRNA catabolic process (GO:0034661)3.44763975
39regulation of chromatin silencing (GO:0031935)3.41147395
40spindle checkpoint (GO:0031577)3.39329320
41DNA replication checkpoint (GO:0000076)3.38553292
42regulation of DNA methylation (GO:0044030)3.34092914
43DNA replication-dependent nucleosome assembly (GO:0006335)3.32665922
44DNA replication-dependent nucleosome organization (GO:0034723)3.32665922
45IMP metabolic process (GO:0046040)3.31688657
46DNA strand elongation (GO:0022616)3.30898563
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.29410422
48DNA double-strand break processing (GO:0000729)3.28981935
49nucleobase biosynthetic process (GO:0046112)3.25738708
50positive regulation of histone methylation (GO:0031062)3.24358387
51CENP-A containing nucleosome assembly (GO:0034080)3.24210046
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.23913447
53mitotic spindle assembly checkpoint (GO:0007094)3.21022261
54histone H3-K36 demethylation (GO:0070544)3.20689058
55purine nucleobase biosynthetic process (GO:0009113)3.20134598
56negative regulation of RNA splicing (GO:0033119)3.19993809
57DNA replication initiation (GO:0006270)3.19760169
58transcription from mitochondrial promoter (GO:0006390)3.18556529
59regulation of sister chromatid segregation (GO:0033045)3.18347249
60regulation of mitotic sister chromatid separation (GO:0010965)3.18347249
61regulation of mitotic sister chromatid segregation (GO:0033047)3.18347249
62DNA replication-independent nucleosome assembly (GO:0006336)3.18201558
63DNA replication-independent nucleosome organization (GO:0034724)3.18201558
64protein complex localization (GO:0031503)3.18196624
65regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18129035
66regulation of mitotic metaphase/anaphase transition (GO:0030071)3.18129035
67regulation of nuclear cell cycle DNA replication (GO:0033262)3.16668701
68negative regulation of gene silencing (GO:0060969)3.15771188
69spindle assembly checkpoint (GO:0071173)3.14679849
70intra-S DNA damage checkpoint (GO:0031573)3.13748480
71negative regulation of mRNA processing (GO:0050686)3.11853241
72double-strand break repair via nonhomologous end joining (GO:0006303)3.07242843
73non-recombinational repair (GO:0000726)3.07242843
74negative regulation of DNA recombination (GO:0045910)3.05553058
75DNA geometric change (GO:0032392)3.03873305
76histone exchange (GO:0043486)3.03753953
77DNA duplex unwinding (GO:0032508)3.02815410
78ATP-dependent chromatin remodeling (GO:0043044)3.01987594
79negative regulation of mRNA metabolic process (GO:1903312)3.01574544
80regulation of chromosome segregation (GO:0051983)3.01140447
81telomere maintenance via semi-conservative replication (GO:0032201)2.97063726
82regulation of histone methylation (GO:0031060)2.96860490
83lysine catabolic process (GO:0006554)2.95910584
84lysine metabolic process (GO:0006553)2.95910584
85mitotic nuclear envelope disassembly (GO:0007077)2.95695193
86cell fate commitment involved in formation of primary germ layer (GO:0060795)2.94490003
87mitotic metaphase plate congression (GO:0007080)2.93122772
88histone arginine methylation (GO:0034969)2.93076811
89paraxial mesoderm development (GO:0048339)2.93013983
90chromatin assembly (GO:0031497)2.92208640
91nucleosome disassembly (GO:0006337)2.91866556
92protein-DNA complex disassembly (GO:0032986)2.91866556
93regulation of histone H3-K4 methylation (GO:0051569)2.90885253
94mitotic G2/M transition checkpoint (GO:0044818)2.84868892
95negative regulation of mitosis (GO:0045839)2.84709648
96termination of RNA polymerase II transcription (GO:0006369)2.81746887
97single strand break repair (GO:0000012)2.80807331
98mitotic chromosome condensation (GO:0007076)2.79099459
99DNA topological change (GO:0006265)2.78378210
100mitochondrial RNA metabolic process (GO:0000959)2.77937632

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.74270661
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.00266950
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.69677625
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.21861289
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.21773764
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.18580337
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.16757955
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.81070180
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70769864
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.59554545
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.59554545
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.59554545
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55232263
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49337318
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.47750688
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33901749
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.33626411
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29241259
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.17368040
20YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13499217
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.02378555
22FOXP3_21729870_ChIP-Seq_TREG_Human2.00293784
23SOX2_16153702_ChIP-ChIP_HESCs_Human1.92412623
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.90827857
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.85970025
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85408383
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78674764
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74852899
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73094429
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72261019
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70532826
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.70066268
33* ETS1_20019798_ChIP-Seq_JURKAT_Human1.69175002
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68873465
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68143353
36NANOG_16153702_ChIP-ChIP_HESCs_Human1.65140468
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65000585
38VDR_23849224_ChIP-Seq_CD4+_Human1.64929199
39TTF2_22483619_ChIP-Seq_HELA_Human1.63728383
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62013495
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61843758
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.61181103
43CIITA_25753668_ChIP-Seq_RAJI_Human1.52440617
44MYC_22102868_ChIP-Seq_BL_Human1.49545688
45NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.49169572
46ELK1_19687146_ChIP-ChIP_HELA_Human1.49097208
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47208318
48ZNF274_21170338_ChIP-Seq_K562_Hela1.45630437
49XRN2_22483619_ChIP-Seq_HELA_Human1.45613066
50IRF1_19129219_ChIP-ChIP_H3396_Human1.44770413
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43100231
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42106486
53SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.41898511
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41882463
55EWS_26573619_Chip-Seq_HEK293_Human1.40607680
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39145310
57MYC_18940864_ChIP-ChIP_HL60_Human1.38269951
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35779012
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34306574
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.31044189
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30573092
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30009101
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29628840
64FUS_26573619_Chip-Seq_HEK293_Human1.27594965
65KDM5A_27292631_Chip-Seq_BREAST_Human1.26028223
66TCF3_18692474_ChIP-Seq_MESCs_Mouse1.23332269
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23173063
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22404197
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22402936
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21874081
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18841071
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18087079
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16040003
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16040003
75GABP_19822575_ChIP-Seq_HepG2_Human1.15694454
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15213539
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14709806
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14547785
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13091232
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.06498058
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06496530
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.05235821
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02222604
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01185185
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01147619
86POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00513488
87SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99025583
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98985957
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98503082
90VDR_22108803_ChIP-Seq_LS180_Human0.93083898
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92265584
92NANOG_21062744_ChIP-ChIP_HESCs_Human0.90369511
93DCP1A_22483619_ChIP-Seq_HELA_Human0.89874282
94EGR1_19374776_ChIP-ChIP_THP-1_Human0.86524344
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84385340
96AR_21909140_ChIP-Seq_LNCAP_Human0.83370771
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81940389
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79803967
99NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.79606566
100SOX2_18692474_ChIP-Seq_MESCs_Mouse0.79189644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.06820220
2MP0003693_abnormal_embryo_hatching4.47296484
3MP0002254_reproductive_system_inflammat3.86642259
4MP0008877_abnormal_DNA_methylation3.82904521
5MP0010094_abnormal_chromosome_stability3.64667508
6MP0003111_abnormal_nucleus_morphology3.47339392
7MP0008058_abnormal_DNA_repair3.14830868
8MP0004957_abnormal_blastocyst_morpholog3.09355419
9MP0006292_abnormal_olfactory_placode2.93984359
10MP0003077_abnormal_cell_cycle2.79723508
11MP0003890_abnormal_embryonic-extraembry2.51949660
12MP0009672_abnormal_birth_weight2.32426705
13MP0003567_abnormal_fetal_cardiomyocyte2.31854392
14MP0003941_abnormal_skin_development2.30141278
15MP0003136_yellow_coat_color2.29876587
16MP0003787_abnormal_imprinting2.17364041
17MP0001293_anophthalmia2.14933136
18MP0003718_maternal_effect2.09701499
19MP0001730_embryonic_growth_arrest2.01692315
20MP0008932_abnormal_embryonic_tissue1.99800193
21MP0010307_abnormal_tumor_latency1.83099837
22MP0000350_abnormal_cell_proliferation1.63803086
23MP0005380_embryogenesis_phenotype1.60334816
24MP0001672_abnormal_embryogenesis/_devel1.60334816
25MP0003878_abnormal_ear_physiology1.58650690
26MP0005377_hearing/vestibular/ear_phenot1.58650690
27MP0002085_abnormal_embryonic_tissue1.51535548
28MP0002084_abnormal_developmental_patter1.47443621
29MP0003937_abnormal_limbs/digits/tail_de1.44905902
30MP0009703_decreased_birth_body1.44692126
31MP0003984_embryonic_growth_retardation1.44249595
32MP0002088_abnormal_embryonic_growth/wei1.41615739
33MP0008007_abnormal_cellular_replicative1.40275562
34MP0003121_genomic_imprinting1.39879921
35MP0002837_dystrophic_cardiac_calcinosis1.37598919
36MP0001697_abnormal_embryo_size1.35799688
37MP0005075_abnormal_melanosome_morpholog1.35017511
38MP0002396_abnormal_hematopoietic_system1.33456154
39MP0006035_abnormal_mitochondrial_morpho1.31369981
40MP0003119_abnormal_digestive_system1.28807002
41MP0002697_abnormal_eye_size1.27039404
42MP0001286_abnormal_eye_development1.24912950
43MP0000313_abnormal_cell_death1.23825959
44MP0004197_abnormal_fetal_growth/weight/1.21997578
45MP0000490_abnormal_crypts_of1.21330699
46MP0002080_prenatal_lethality1.14456423
47MP0001188_hyperpigmentation1.14209633
48MP0003861_abnormal_nervous_system1.13338359
49MP0001346_abnormal_lacrimal_gland1.10541852
50MP0002163_abnormal_gland_morphology1.10162651
51MP0003646_muscle_fatigue1.07931555
52MP0002233_abnormal_nose_morphology1.04526166
53MP0000703_abnormal_thymus_morphology1.03940607
54MP0004133_heterotaxia1.03667872
55MP0002111_abnormal_tail_morphology1.03133271
56MP0002210_abnormal_sex_determination1.02431620
57MP0005499_abnormal_olfactory_system0.97709457
58MP0005394_taste/olfaction_phenotype0.97709457
59MP0001145_abnormal_male_reproductive0.94742507
60MP0001929_abnormal_gametogenesis0.94640250
61MP0002938_white_spotting0.93694541
62MP0000428_abnormal_craniofacial_morphol0.92675339
63MP0008995_early_reproductive_senescence0.86430810
64MP0003938_abnormal_ear_development0.85476685
65MP0003786_premature_aging0.85317379
66MP0002090_abnormal_vision0.84314169
67MP0002086_abnormal_extraembryonic_tissu0.84078173
68MP0000653_abnormal_sex_gland0.82897765
69MP0000537_abnormal_urethra_morphology0.79530572
70MP0003221_abnormal_cardiomyocyte_apopto0.79005875
71MP0006072_abnormal_retinal_apoptosis0.78046260
72MP0008789_abnormal_olfactory_epithelium0.77622324
73MP0000049_abnormal_middle_ear0.77566977
74MP0000631_abnormal_neuroendocrine_gland0.76417049
75MP0010030_abnormal_orbit_morphology0.75374260
76MP0000358_abnormal_cell_content/0.74262414
77MP0002019_abnormal_tumor_incidence0.73575932
78MP0000689_abnormal_spleen_morphology0.73249775
79MP0003698_abnormal_male_reproductive0.73053475
80MP0002092_abnormal_eye_morphology0.70829287
81MP0000432_abnormal_head_morphology0.70274585
82MP0010352_gastrointestinal_tract_polyps0.69431819
83MP0009278_abnormal_bone_marrow0.69065048
84MP0001485_abnormal_pinna_reflex0.69046593
85MP0003123_paternal_imprinting0.68545718
86MP0008770_decreased_survivor_rate0.66613881
87MP0003763_abnormal_thymus_physiology0.66431166
88MP0004264_abnormal_extraembryonic_tissu0.66177936
89MP0005391_vision/eye_phenotype0.65623996
90MP0002398_abnormal_bone_marrow0.64849552
91MP0009697_abnormal_copulation0.62217300
92MP0005379_endocrine/exocrine_gland_phen0.61486200
93MP0005671_abnormal_response_to0.60172677
94MP0000372_irregular_coat_pigmentation0.59808596
95MP0002722_abnormal_immune_system0.59551598
96MP0005395_other_phenotype0.59455509
97MP0001119_abnormal_female_reproductive0.57516290
98MP0005220_abnormal_exocrine_pancreas0.57261802
99MP0005647_abnormal_sex_gland0.56255709
100MP0003122_maternal_imprinting0.55512551

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)4.63858570
2Abnormality of the labia minora (HP:0012880)4.29559083
3Hepatoblastoma (HP:0002884)4.23420712
4Septo-optic dysplasia (HP:0100842)3.32568363
5Nephroblastoma (Wilms tumor) (HP:0002667)3.17141282
6Birth length less than 3rd percentile (HP:0003561)3.08504742
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.06220402
8Chromsome breakage (HP:0040012)2.92798822
9Cortical dysplasia (HP:0002539)2.92553479
10Embryonal renal neoplasm (HP:0011794)2.88128384
11Neoplasm of the adrenal cortex (HP:0100641)2.86969531
12Rhabdomyosarcoma (HP:0002859)2.84898117
13Medulloblastoma (HP:0002885)2.76574147
14Carpal bone hypoplasia (HP:0001498)2.71729053
15Reticulocytopenia (HP:0001896)2.71238806
16Spastic diplegia (HP:0001264)2.68691473
17Meckel diverticulum (HP:0002245)2.65186779
18Abnormality of homocysteine metabolism (HP:0010919)2.64094185
19Homocystinuria (HP:0002156)2.64094185
20Ectopic kidney (HP:0000086)2.61568103
21Aplasia/Hypoplasia of the sternum (HP:0006714)2.58624280
22Abnormal lung lobation (HP:0002101)2.56999153
23Ependymoma (HP:0002888)2.55308554
24Abnormality of chromosome stability (HP:0003220)2.53727413
25Abnormality of the ileum (HP:0001549)2.51112558
26Bilateral microphthalmos (HP:0007633)2.37744671
27Choanal stenosis (HP:0000452)2.35032098
28Absent radius (HP:0003974)2.32731523
29Stenosis of the external auditory canal (HP:0000402)2.31940891
30Abnormality of the septum pellucidum (HP:0007375)2.30921444
31Abnormal number of incisors (HP:0011064)2.29489298
32Intestinal atresia (HP:0011100)2.28696232
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.24932594
34Impulsivity (HP:0100710)2.23351551
35Multiple enchondromatosis (HP:0005701)2.22664700
36Cellular immunodeficiency (HP:0005374)2.19065870
37Aqueductal stenosis (HP:0002410)2.18292119
38Agnosia (HP:0010524)2.17894822
39Aplasia involving forearm bones (HP:0009822)2.15937309
40Absent forearm bone (HP:0003953)2.15937309
41Hyperglycinemia (HP:0002154)2.12760209
42Embryonal neoplasm (HP:0002898)2.11254030
43Sloping forehead (HP:0000340)2.10831403
44Basal cell carcinoma (HP:0002671)2.09558706
45Hyperglycinuria (HP:0003108)2.09446376
46Absent eyebrow (HP:0002223)2.07220580
47Stomach cancer (HP:0012126)2.06428320
48Neoplasm of striated muscle (HP:0009728)2.05978828
49Absent septum pellucidum (HP:0001331)2.05210321
50Esophageal atresia (HP:0002032)2.05070667
51IgM deficiency (HP:0002850)2.03977605
52Protruding tongue (HP:0010808)2.03856071
53Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01954384
54Maternal diabetes (HP:0009800)2.00165580
55Clitoromegaly (HP:0000057)1.98907034
56Optic nerve hypoplasia (HP:0000609)1.98343014
57Glioma (HP:0009733)1.98317913
58Abnormal hair whorl (HP:0010721)1.95853082
59Horseshoe kidney (HP:0000085)1.94248385
60Abnormality of the preputium (HP:0100587)1.94174395
61Volvulus (HP:0002580)1.93596831
62Cupped ear (HP:0000378)1.93451217
63Facial cleft (HP:0002006)1.92454725
64Pancreatic islet-cell hyperplasia (HP:0004510)1.90830210
65Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.89583382
66Neoplasm of the colon (HP:0100273)1.88848617
67Biliary tract neoplasm (HP:0100574)1.88569483
68Gastrointestinal atresia (HP:0002589)1.88515497
69Cleft eyelid (HP:0000625)1.88336469
70Triphalangeal thumb (HP:0001199)1.85172830
71Abnormality of the duodenum (HP:0002246)1.83986923
72Chronic bronchitis (HP:0004469)1.83282018
73Diastasis recti (HP:0001540)1.83275674
74Optic nerve coloboma (HP:0000588)1.83191544
75Abnormality of glycine metabolism (HP:0010895)1.82497688
76Abnormality of serine family amino acid metabolism (HP:0010894)1.82497688
77Skull defect (HP:0001362)1.81976242
78Neoplasm of the oral cavity (HP:0100649)1.80147653
79Selective tooth agenesis (HP:0001592)1.80108813
80Small intestinal stenosis (HP:0012848)1.78255943
81Duodenal stenosis (HP:0100867)1.78255943
82Patellar aplasia (HP:0006443)1.77905195
83Progressive inability to walk (HP:0002505)1.77195768
84Abnormality of the astrocytes (HP:0100707)1.76411219
85Astrocytoma (HP:0009592)1.76411219
86Absent thumb (HP:0009777)1.76276918
87Intestinal fistula (HP:0100819)1.74305263
88Rectal fistula (HP:0100590)1.74166227
89Rectovaginal fistula (HP:0000143)1.74166227
90Abnormality of DNA repair (HP:0003254)1.73374614
91Anophthalmia (HP:0000528)1.72075987
92Breast aplasia (HP:0100783)1.71576510
93Dandy-Walker malformation (HP:0001305)1.71366107
94Malignant gastrointestinal tract tumors (HP:0006749)1.70481655
95Gastrointestinal carcinoma (HP:0002672)1.70481655
96Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70418360
97Cutaneous syndactyly (HP:0012725)1.69540851
98High anterior hairline (HP:0009890)1.68780478
99Abnormal biliary tract physiology (HP:0012439)1.68514652
100Bile duct proliferation (HP:0001408)1.68514652

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.93206066
2SRPK13.19406340
3MKNK13.11244304
4MKNK23.10542058
5MAP3K103.01510332
6TTK2.87949329
7TSSK62.45206076
8BUB12.37710523
9PASK2.36540611
10CDK192.30452822
11TNIK2.28656357
12ZAK2.27044400
13PLK42.09340258
14TAF12.01523622
15BRD42.01320559
16PLK31.96311402
17CDK121.72312118
18NUAK11.69465376
19WNK31.68780540
20FGFR21.67393032
21ATR1.48564777
22VRK21.47693006
23DYRK21.41111568
24DYRK31.39673271
25EEF2K1.33542765
26CAMK1D1.33328121
27BRSK21.33264916
28TEC1.25960211
29PLK11.23399808
30BCR1.20995759
31STK31.20500649
32ALK1.18621644
33ACVR1B1.17632215
34ATM1.15309482
35CAMK1G1.12834078
36CHEK21.12355185
37NLK1.11106390
38VRK11.10373038
39FRK1.07442705
40FGFR11.07255963
41CHEK11.06996685
42MST41.05608663
43TYRO31.04869242
44STK111.02124028
45BMPR1B0.97849214
46NEK20.96386231
47SMG10.94451462
48PIM10.94039517
49MAP4K10.93666459
50TRIM280.89707196
51STK38L0.87580649
52FES0.82024246
53WEE10.81838086
54BTK0.80017628
55CDK20.78818394
56TGFBR10.76438111
57LATS10.74931632
58CDK40.74336870
59AURKB0.71815174
60CDK10.71599783
61MAP3K40.68998316
62PRKDC0.65755140
63YES10.65721657
64CDK70.65514569
65CSNK1G10.63969245
66STK40.63908724
67FGR0.63480479
68ITK0.62249811
69PBK0.59575936
70CDK30.54653633
71CLK10.54545678
72MAP3K70.51327519
73CSNK1E0.50957242
74MAP3K90.47104307
75GSK3B0.46402663
76EIF2AK20.46238837
77NME10.46200167
78RPS6KA40.45233021
79DYRK1A0.44878395
80MARK30.43185461
81NEK10.42763326
82CSNK1G20.42018490
83STK160.41642947
84CASK0.41591741
85STK240.41147143
86NTRK20.41129404
87OXSR10.40545622
88RPS6KB20.35924856
89EGFR0.35565147
90EIF2AK30.34955810
91PRKCQ0.34617628
92CSNK2A20.33320005
93BMX0.32828973
94AKT10.31895181
95LYN0.31806418
96MAPK140.31534056
97RPS6KA10.30692655
98SIK30.28848377
99CDK60.28238750
100LCK0.27754894

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.98621276
2Mismatch repair_Homo sapiens_hsa034303.81425317
3Non-homologous end-joining_Homo sapiens_hsa034503.74343450
4Homologous recombination_Homo sapiens_hsa034403.37971359
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37306276
6Spliceosome_Homo sapiens_hsa030403.29476422
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.27156193
8RNA transport_Homo sapiens_hsa030132.91913353
9Base excision repair_Homo sapiens_hsa034102.86807205
10Cell cycle_Homo sapiens_hsa041102.75340478
11Fanconi anemia pathway_Homo sapiens_hsa034602.52416482
12Basal transcription factors_Homo sapiens_hsa030222.52168252
13One carbon pool by folate_Homo sapiens_hsa006702.51678253
14mRNA surveillance pathway_Homo sapiens_hsa030152.46900446
15RNA degradation_Homo sapiens_hsa030182.46490788
16Selenocompound metabolism_Homo sapiens_hsa004502.44377747
17RNA polymerase_Homo sapiens_hsa030202.35072731
18Nucleotide excision repair_Homo sapiens_hsa034201.91500615
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.90720092
20Lysine degradation_Homo sapiens_hsa003101.84978358
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78259278
22Ribosome_Homo sapiens_hsa030101.76415330
23Steroid biosynthesis_Homo sapiens_hsa001001.38196067
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29832686
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25759359
26Primary immunodeficiency_Homo sapiens_hsa053401.22951817
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16116469
28Adherens junction_Homo sapiens_hsa045201.15632658
29Colorectal cancer_Homo sapiens_hsa052101.11647176
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10345871
31p53 signaling pathway_Homo sapiens_hsa041151.08446244
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08368132
33Pyrimidine metabolism_Homo sapiens_hsa002401.07829710
34Purine metabolism_Homo sapiens_hsa002301.03178569
35Oocyte meiosis_Homo sapiens_hsa041140.99883995
36Wnt signaling pathway_Homo sapiens_hsa043100.98829169
37Propanoate metabolism_Homo sapiens_hsa006400.97389033
38Biosynthesis of amino acids_Homo sapiens_hsa012300.94535850
39Basal cell carcinoma_Homo sapiens_hsa052170.93168522
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84277009
41MicroRNAs in cancer_Homo sapiens_hsa052060.82307363
42Thyroid cancer_Homo sapiens_hsa052160.77677083
43Herpes simplex infection_Homo sapiens_hsa051680.74386287
44Epstein-Barr virus infection_Homo sapiens_hsa051690.71110668
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68866950
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67724429
47Notch signaling pathway_Homo sapiens_hsa043300.64926094
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63097439
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62602253
50Prostate cancer_Homo sapiens_hsa052150.60814875
51Viral carcinogenesis_Homo sapiens_hsa052030.59586472
52Hedgehog signaling pathway_Homo sapiens_hsa043400.56997653
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56906347
54Tight junction_Homo sapiens_hsa045300.56772399
55Hippo signaling pathway_Homo sapiens_hsa043900.56153081
56Vitamin B6 metabolism_Homo sapiens_hsa007500.51924195
57T cell receptor signaling pathway_Homo sapiens_hsa046600.50840272
58Pyruvate metabolism_Homo sapiens_hsa006200.49663113
59Proteasome_Homo sapiens_hsa030500.48585944
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46848871
61Taste transduction_Homo sapiens_hsa047420.46745479
62Carbon metabolism_Homo sapiens_hsa012000.46194525
63HTLV-I infection_Homo sapiens_hsa051660.40872401
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40146134
65Ether lipid metabolism_Homo sapiens_hsa005650.37852752
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37201359
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36589927
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36453080
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33048723
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.32613246
71Phototransduction_Homo sapiens_hsa047440.29972386
72Endometrial cancer_Homo sapiens_hsa052130.28821093
73FoxO signaling pathway_Homo sapiens_hsa040680.28684859
74TGF-beta signaling pathway_Homo sapiens_hsa043500.26702457
75B cell receptor signaling pathway_Homo sapiens_hsa046620.24980637
76Vitamin digestion and absorption_Homo sapiens_hsa049770.24746367
77Regulation of autophagy_Homo sapiens_hsa041400.20848941
78Olfactory transduction_Homo sapiens_hsa047400.20808194
79Inositol phosphate metabolism_Homo sapiens_hsa005620.19838130
80Circadian rhythm_Homo sapiens_hsa047100.19588887
81Huntingtons disease_Homo sapiens_hsa050160.17820226
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17660802
83Long-term depression_Homo sapiens_hsa047300.17561832
84Antigen processing and presentation_Homo sapiens_hsa046120.17082027
85Measles_Homo sapiens_hsa051620.17002628
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15611887
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.13665648
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13301311
89Glucagon signaling pathway_Homo sapiens_hsa049220.13202493
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.12597215
91Metabolic pathways_Homo sapiens_hsa011000.12457556
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12439571
93Protein export_Homo sapiens_hsa030600.12201869
94Acute myeloid leukemia_Homo sapiens_hsa052210.11338067
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09697065
96Viral myocarditis_Homo sapiens_hsa054160.09487876
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09329880
98Apoptosis_Homo sapiens_hsa042100.07389549
99Pathways in cancer_Homo sapiens_hsa052000.07093843
100Nicotine addiction_Homo sapiens_hsa050330.06725598

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »