ZNF592

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is thought to play a role in a complex developmental pathway and the regulation of genes involved in cerebellar development. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.96530909
2positive regulation of gamma-delta T cell activation (GO:0046645)4.59345626
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.36343136
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.36343136
5modulation by symbiont of host immune response (GO:0052553)4.36343136
6positive regulation by symbiont of host defense response (GO:0052509)4.36343136
7modulation by symbiont of host defense response (GO:0052031)4.36343136
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.36343136
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.19711179
10negative regulation of cell killing (GO:0031342)4.19711179
11response to peptidoglycan (GO:0032494)3.86515040
12macrophage activation involved in immune response (GO:0002281)3.71692779
13histone H3-K36 demethylation (GO:0070544)3.68189207
14detection of other organism (GO:0098543)3.66095360
15response to muramyl dipeptide (GO:0032495)3.62139408
16regulation of gamma-delta T cell activation (GO:0046643)3.61091352
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.59385809
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.48559622
19detection of bacterium (GO:0016045)3.48334524
20regulation of gamma-delta T cell differentiation (GO:0045586)3.37714687
21antigen processing and presentation of endogenous antigen (GO:0019883)3.36999223
22cellular extravasation (GO:0045123)3.32476972
23mannose metabolic process (GO:0006013)3.25090916
24neutrophil activation involved in immune response (GO:0002283)3.20675407
25response to laminar fluid shear stress (GO:0034616)3.19787311
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.19070911
273-UTR-mediated mRNA stabilization (GO:0070935)3.17877183
28response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.17149737
29response to host (GO:0075136)3.17149737
30response to host defenses (GO:0052200)3.17149737
31detection of external biotic stimulus (GO:0098581)3.15987295
32detection of molecule of bacterial origin (GO:0032490)3.15666233
33germinal center formation (GO:0002467)3.14096801
34positive thymic T cell selection (GO:0045059)3.13778804
35regulation of B cell receptor signaling pathway (GO:0050855)3.10267453
36response to host immune response (GO:0052572)3.06769520
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.06769520
38leukocyte aggregation (GO:0070486)3.06157814
39B cell receptor signaling pathway (GO:0050853)2.99744316
40regulation of interferon-beta biosynthetic process (GO:0045357)2.99061589
41embryonic process involved in female pregnancy (GO:0060136)2.98184136
42positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.93737942
43regulation of leukocyte degranulation (GO:0043300)2.92926228
44thymic T cell selection (GO:0045061)2.91755080
45negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.91212910
46positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85633302
47T cell selection (GO:0045058)2.81872831
48negative thymic T cell selection (GO:0045060)2.79875463
49regulation of myeloid leukocyte mediated immunity (GO:0002886)2.77819144
50detection of biotic stimulus (GO:0009595)2.75520028
51regulation of necroptotic process (GO:0060544)2.75101068
52regulation of histone H3-K27 methylation (GO:0061085)2.74732834
53regulation of T-helper 2 cell differentiation (GO:0045628)2.73958915
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.73913620
55negative regulation of interleukin-12 production (GO:0032695)2.73260576
56regulation of NFAT protein import into nucleus (GO:0051532)2.72686952
57histone lysine demethylation (GO:0070076)2.71767116
58positive regulation of Cdc42 GTPase activity (GO:0043089)2.69915877
59positive T cell selection (GO:0043368)2.69533880
60regulation of mast cell degranulation (GO:0043304)2.69321580
61negative regulation of toll-like receptor signaling pathway (GO:0034122)2.65186573
62histone H3-K9 demethylation (GO:0033169)2.61798447
63negative regulation of lymphocyte mediated immunity (GO:0002707)2.61466407
64modulation by symbiont of host cellular process (GO:0044068)2.58478905
65modulation by virus of host process (GO:0019054)2.58073270
66histone demethylation (GO:0016577)2.57909204
67negative regulation of myotube differentiation (GO:0010832)2.57664755
68negative T cell selection (GO:0043383)2.56918120
69intracellular estrogen receptor signaling pathway (GO:0030520)2.55717706
70positive regulation of cellular amide metabolic process (GO:0034250)2.54817159
71macrophage activation (GO:0042116)2.54693351
72positive regulation of Rap GTPase activity (GO:0032854)2.52971411
73positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.51096059
74negative regulation of leukocyte mediated immunity (GO:0002704)2.50709873
75lipopolysaccharide-mediated signaling pathway (GO:0031663)2.50676160
76regulation of ARF protein signal transduction (GO:0032012)2.50480059
77regulation of ARF GTPase activity (GO:0032312)2.48622682
78positive regulation of granulocyte differentiation (GO:0030854)2.47548861
79epithelial cell differentiation involved in prostate gland development (GO:0060742)2.47206744
80antigen processing and presentation via MHC class Ib (GO:0002475)2.46416517
81neutrophil activation (GO:0042119)2.46150449
82regulation of regulated secretory pathway (GO:1903305)2.43289281
83signal complex assembly (GO:0007172)2.42331612
84production of molecular mediator involved in inflammatory response (GO:0002532)2.41849409
85regulation of type I interferon-mediated signaling pathway (GO:0060338)2.41064750
86focal adhesion assembly (GO:0048041)2.39875061
87cell-substrate adherens junction assembly (GO:0007045)2.39875061
88regulation of mast cell activation involved in immune response (GO:0033006)2.37162154
89stress fiber assembly (GO:0043149)2.36812334
90positive regulation of histone deacetylation (GO:0031065)2.35236815
91megakaryocyte development (GO:0035855)2.34820334
92myeloid cell activation involved in immune response (GO:0002275)2.33918996
93negative regulation of necroptotic process (GO:0060546)2.33894856
94positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.33795928
95response to interleukin-15 (GO:0070672)2.33155319
96protein localization to endosome (GO:0036010)2.33088355
97adherens junction assembly (GO:0034333)2.32242097
98granulocyte activation (GO:0036230)2.32071427
99negative regulation of T cell mediated immunity (GO:0002710)2.31732180
100JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.30067888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.52327646
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.50252787
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.18900836
4VDR_21846776_ChIP-Seq_THP-1_Human3.15681182
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.82980044
6TCF7_22412390_ChIP-Seq_EML_Mouse2.82754164
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.64523782
8KDM2B_26808549_Chip-Seq_DND41_Human2.50729204
9VDR_24763502_ChIP-Seq_THP-1_Human2.41286447
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40743475
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34394887
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.33378873
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.30751993
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.28659621
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27389330
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.25319655
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.23516093
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22707115
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16174682
20* MAF_26560356_Chip-Seq_TH1_Human2.14748943
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14488779
22LXR_22292898_ChIP-Seq_THP-1_Human2.09728205
23SCL_19346495_ChIP-Seq_HPC-7_Human2.01313054
24SPI1_23127762_ChIP-Seq_K562_Human1.95557002
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92635656
26* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92139232
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.90000284
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89049871
29UTX_26944678_Chip-Seq_JUKART_Human1.87592535
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.85512964
31KDM2B_26808549_Chip-Seq_JURKAT_Human1.82869561
32KDM2B_26808549_Chip-Seq_K562_Human1.82082284
33* RACK7_27058665_Chip-Seq_MCF-7_Human1.78497485
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78225495
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77104096
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76327829
37TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.72399423
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.72369714
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65786911
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64359461
41MAF_26560356_Chip-Seq_TH2_Human1.63926764
42RUNX_20019798_ChIP-Seq_JUKART_Human1.63253311
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.61343598
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58914482
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54175938
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.49744571
47MYB_26560356_Chip-Seq_TH1_Human1.46887178
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46183466
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.44504867
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44155588
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41460756
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.40313660
53SPI1_23547873_ChIP-Seq_NB4_Human1.36600513
54GATA1_19941826_ChIP-Seq_K562_Human1.36149178
55MYB_26560356_Chip-Seq_TH2_Human1.34965440
56NCOR1_26117541_ChIP-Seq_K562_Human1.34908638
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33947815
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33725184
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32625045
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32305610
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32198044
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29252145
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27212038
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26565718
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25965311
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25358537
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25026920
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22882763
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19443182
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19206796
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.18681606
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15412652
73ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14537036
74GATA1_22025678_ChIP-Seq_K562_Human1.13991455
75CREB1_26743006_Chip-Seq_LNCaP_Human1.11908421
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11317552
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11168243
78SMC4_20622854_ChIP-Seq_HELA_Human1.10432504
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10150533
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10122527
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10053649
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08511792
83PU_27001747_Chip-Seq_BMDM_Mouse1.07369342
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07366825
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.06697204
86CLOCK_20551151_ChIP-Seq_293T_Human1.06497152
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05530246
88VDR_24787735_ChIP-Seq_THP-1_Human1.00922487
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00007001
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99517012
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98924196
92SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97986481
93GATA2_19941826_ChIP-Seq_K562_Human0.97888708
94PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96313208
95P68_20966046_ChIP-Seq_HELA_Human0.96303966
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95572304
97PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95188064
98TBX20_22328084_ChIP-Seq_HEART_Mouse0.95036220
99TBX20_22080862_ChIP-Seq_HEART_Mouse0.95036220
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94353904

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.45447785
2MP0003303_peritoneal_inflammation3.14445627
3MP0003436_decreased_susceptibility_to3.13337519
4MP0003705_abnormal_hypodermis_morpholog2.88446062
5MP0005076_abnormal_cell_differentiation2.74087553
6MP0003300_gastrointestinal_ulcer2.65744450
7MP0008260_abnormal_autophagy2.43742326
8MP0003172_abnormal_lysosome_physiology2.34502165
9MP0009278_abnormal_bone_marrow2.32209000
10MP0003724_increased_susceptibility_to2.31213347
11MP0003763_abnormal_thymus_physiology2.28453933
12MP0002396_abnormal_hematopoietic_system2.23385922
13MP0001835_abnormal_antigen_presentation2.12327090
14MP0003191_abnormal_cellular_cholesterol2.08400413
15MP0002419_abnormal_innate_immunity2.06727935
16MP0003828_pulmonary_edema2.01593557
17MP0005058_abnormal_lysosome_morphology1.96540388
18MP0002009_preneoplasia1.87442286
19MP0001800_abnormal_humoral_immune1.86433663
20MP0004947_skin_inflammation1.83921703
21MP0005025_abnormal_response_to1.81719097
22MP0000685_abnormal_immune_system1.77960067
23MP0005000_abnormal_immune_tolerance1.75554034
24MP0004185_abnormal_adipocyte_glucose1.73762963
25MP0003091_abnormal_cell_migration1.73758906
26MP0005387_immune_system_phenotype1.72758054
27MP0001790_abnormal_immune_system1.72758054
28MP0004808_abnormal_hematopoietic_stem1.64732314
29MP0002420_abnormal_adaptive_immunity1.64355071
30MP0001819_abnormal_immune_cell1.62135247
31MP0002723_abnormal_immune_serum1.60796996
32MP0002398_abnormal_bone_marrow1.59864795
33MP0002452_abnormal_antigen_presenting1.59082990
34MP0004510_myositis1.54747487
35MP0005464_abnormal_platelet_physiology1.50329289
36MP0003566_abnormal_cell_adhesion1.49458506
37MP0005409_darkened_coat_color1.46209749
38MP0000703_abnormal_thymus_morphology1.44895863
39MP0001545_abnormal_hematopoietic_system1.44723196
40MP0005397_hematopoietic_system_phenotyp1.44723196
41MP0002405_respiratory_system_inflammati1.44628202
42MP0003453_abnormal_keratinocyte_physiol1.44183906
43MP0002166_altered_tumor_susceptibility1.39653023
44MP0005666_abnormal_adipose_tissue1.39037303
45MP0009840_abnormal_foam_cell1.37664727
46MP0001533_abnormal_skeleton_physiology1.37648773
47MP0000716_abnormal_immune_system1.37407395
48MP0002998_abnormal_bone_remodeling1.35680397
49MP0004381_abnormal_hair_follicle1.33642751
50MP0004233_abnormal_muscle_weight1.33532105
51MP0000858_altered_metastatic_potential1.31439124
52MP0009333_abnormal_splenocyte_physiolog1.29626394
53MP0002722_abnormal_immune_system1.28389355
54MP0010155_abnormal_intestine_physiology1.25653809
55MP0003656_abnormal_erythrocyte_physiolo1.23166344
56MP0004264_abnormal_extraembryonic_tissu1.20692021
57MP0005310_abnormal_salivary_gland1.20661483
58MP0004130_abnormal_muscle_cell1.20256676
59MP0003221_abnormal_cardiomyocyte_apopto1.18718665
60MP0000689_abnormal_spleen_morphology1.18028699
61MP0002429_abnormal_blood_cell1.16493624
62MP0003183_abnormal_peptide_metabolism1.15045150
63MP0001849_ear_inflammation1.14615287
64MP0001873_stomach_inflammation1.13095795
65MP0001851_eye_inflammation1.12711829
66MP0010352_gastrointestinal_tract_polyps1.12352947
67MP0002877_abnormal_melanocyte_morpholog1.11817972
68MP0009785_altered_susceptibility_to1.10208961
69MP0003690_abnormal_glial_cell1.10085405
70MP0005375_adipose_tissue_phenotype1.09693942
71MP0006082_CNS_inflammation1.05052926
72MP0009115_abnormal_fat_cell1.02538294
73MP0010630_abnormal_cardiac_muscle1.01721244
74MP0005671_abnormal_response_to1.01126676
75MP0002132_abnormal_respiratory_system0.98783930
76MP0005621_abnormal_cell_physiology0.98577007
77MP0001845_abnormal_inflammatory_respons0.97599716
78MP0003866_abnormal_defecation0.97262473
79MP0004858_abnormal_nervous_system0.96291569
80MP0000733_abnormal_muscle_development0.94825251
81MP0001915_intracranial_hemorrhage0.94718747
82MP0002148_abnormal_hypersensitivity_rea0.89909749
83MP0010234_abnormal_vibrissa_follicle0.89339777
84MP0004087_abnormal_muscle_fiber0.89147511
85MP0000747_muscle_weakness0.88683926
86MP0008057_abnormal_DNA_replication0.85571798
87MP0001853_heart_inflammation0.83743832
88MP0000759_abnormal_skeletal_muscle0.83092693
89MP0002332_abnormal_exercise_endurance0.82889587
90MP0008004_abnormal_stomach_pH0.82602360
91MP0004883_abnormal_blood_vessel0.79540887
92MP0008469_abnormal_protein_level0.78493304
93MP0000465_gastrointestinal_hemorrhage0.78344036
94MP0003448_altered_tumor_morphology0.75789160
95MP0008961_abnormal_basal_metabolism0.75637237
96MP0003075_altered_response_to0.75153472
97MP0002006_tumorigenesis0.74604748
98MP0003045_fibrosis0.73403830
99MP0000767_abnormal_smooth_muscle0.73250364
100MP0002971_abnormal_brown_adipose0.71841903

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.37071017
2Abnormality of the fingertips (HP:0001211)3.53052322
3Recurrent abscess formation (HP:0002722)3.31003827
4Recurrent bacterial skin infections (HP:0005406)3.24933526
5Abnormality of macrophages (HP:0004311)3.06521486
6Obstructive sleep apnea (HP:0002870)3.04609746
7Cellulitis (HP:0100658)2.71819801
8Increased IgE level (HP:0003212)2.67219730
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.65938848
10Myositis (HP:0100614)2.63960885
11Gingivitis (HP:0000230)2.63358491
12Spontaneous hematomas (HP:0007420)2.60990063
13Recurrent gram-negative bacterial infections (HP:0005420)2.59440941
14Colitis (HP:0002583)2.54692291
15Centrally nucleated skeletal muscle fibers (HP:0003687)2.52085517
16Broad face (HP:0000283)2.50287061
17Orchitis (HP:0100796)2.49525546
18Increased connective tissue (HP:0009025)2.47990640
19Gastrointestinal infarctions (HP:0005244)2.43491987
20Distal lower limb amyotrophy (HP:0008944)2.40301679
21Difficulty running (HP:0009046)2.38801540
22Exercise-induced myalgia (HP:0003738)2.33668373
23Cerebral aneurysm (HP:0004944)2.30785357
24Mediastinal lymphadenopathy (HP:0100721)2.30192581
25Gastrointestinal inflammation (HP:0004386)2.29138013
26Slow saccadic eye movements (HP:0000514)2.26219054
27Recurrent fungal infections (HP:0002841)2.26004316
28Prolonged bleeding time (HP:0003010)2.19972812
29Meningitis (HP:0001287)2.18069604
30Abnormality of skeletal muscle fiber size (HP:0012084)2.15413966
31Increased variability in muscle fiber diameter (HP:0003557)2.15194206
32Inflammation of the large intestine (HP:0002037)2.14981682
33Retrobulbar optic neuritis (HP:0100654)2.14106555
34Optic neuritis (HP:0100653)2.14106555
35Chronic obstructive pulmonary disease (HP:0006510)2.10634420
36Obstructive lung disease (HP:0006536)2.10634420
37Recurrent skin infections (HP:0001581)2.05626857
38Flat acetabular roof (HP:0003180)2.04422776
39Long eyelashes (HP:0000527)2.00844529
40Chest pain (HP:0100749)2.00606226
41Recurrent viral infections (HP:0004429)2.00359081
42Abnormal delayed hypersensitivity skin test (HP:0002963)1.99689254
43Abnormality of the columella (HP:0009929)1.99283586
44Abnormality of the distal phalanx of the thumb (HP:0009617)1.98002440
45Hyperacusis (HP:0010780)1.97455428
46Subacute progressive viral hepatitis (HP:0006572)1.92407302
47Metaphyseal cupping (HP:0003021)1.91469446
48Dislocated radial head (HP:0003083)1.89270872
49Aneurysm (HP:0002617)1.88822125
50Spinal cord lesions (HP:0100561)1.88443762
51Syringomyelia (HP:0003396)1.88443762
52Fatigue (HP:0012378)1.88039591
53Segmental peripheral demyelination/remyelination (HP:0003481)1.86306728
54Gingival bleeding (HP:0000225)1.85557224
55Epistaxis (HP:0000421)1.85244031
56Viral hepatitis (HP:0006562)1.83895805
57Subaortic stenosis (HP:0001682)1.83549873
58Abnormality of the left ventricular outflow tract (HP:0011103)1.83549873
59Recurrent cutaneous fungal infections (HP:0011370)1.81721679
60Chronic mucocutaneous candidiasis (HP:0002728)1.81721679
61Abnormality of the thoracic spine (HP:0100711)1.81596178
62Disproportionate tall stature (HP:0001519)1.81538255
63Vasculitis (HP:0002633)1.81051980
64Arterial thrombosis (HP:0004420)1.80675094
65Polycythemia (HP:0001901)1.80547621
66Osteomyelitis (HP:0002754)1.80150107
67Hemorrhage of the eye (HP:0011885)1.79626741
68Thoracic kyphosis (HP:0002942)1.78316117
69Increased cerebral lipofuscin (HP:0011813)1.77716186
70Dysmetric saccades (HP:0000641)1.77504416
71Neonatal hypoglycemia (HP:0001998)1.75454274
72Abnormality of the radial head (HP:0003995)1.73967054
73Peritonitis (HP:0002586)1.73925565
74Hypochromic anemia (HP:0001931)1.71924046
75Distal lower limb muscle weakness (HP:0009053)1.71547543
76Urticaria (HP:0001025)1.70898424
77Asymmetric septal hypertrophy (HP:0001670)1.67934774
78Keratoconjunctivitis sicca (HP:0001097)1.67310354
79Easy fatigability (HP:0003388)1.67100154
80Germ cell neoplasia (HP:0100728)1.66338156
81Onion bulb formation (HP:0003383)1.66303524
82Amyloidosis (HP:0011034)1.66183616
83Abnormality of the peritoneum (HP:0002585)1.65632606
84Dilatation of the ascending aorta (HP:0005111)1.61001400
85Abnormal platelet volume (HP:0011876)1.60261188
86Asymmetry of the thorax (HP:0001555)1.59803202
87Macroorchidism (HP:0000053)1.59594379
88Pustule (HP:0200039)1.59010204
89Polygenic inheritance (HP:0010982)1.58635898
90Myopathic facies (HP:0002058)1.58198812
91Thin bony cortex (HP:0002753)1.57685526
92Elevated erythrocyte sedimentation rate (HP:0003565)1.57311815
93Narrow palate (HP:0000189)1.56534481
94Long palpebral fissure (HP:0000637)1.55432095
95Lower limb amyotrophy (HP:0007210)1.55173592
96Encephalitis (HP:0002383)1.54799086
97Ankyloglossia (HP:0010296)1.54637402
98Interstitial pulmonary disease (HP:0006530)1.53690673
99Gastrointestinal stroma tumor (HP:0100723)1.51962878
100Mitral valve prolapse (HP:0001634)1.51435782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.69736521
2TRIB33.64178085
3CDK123.25522253
4RIPK42.89923937
5ERN12.81431615
6MAP2K32.47828823
7SMG12.33902406
8SIK12.30299216
9ICK2.24478998
10MAP4K12.23973272
11MAP3K101.98035443
12EEF2K1.88933661
13IRAK41.79553253
14TYK21.74396843
15MARK21.72875636
16BLK1.71140264
17FGFR41.68370407
18KSR21.62873054
19TTN1.56507899
20TAOK11.53148338
21EPHB11.49849333
22CAMK1D1.45480548
23MAP3K131.42858243
24MAP3K31.41259791
25RIPK11.40373197
26ZAP701.39490401
27TNK21.38630283
28IRAK31.38377484
29BRD41.36206683
30CSK1.34421857
31PKN21.26075649
32MAP3K11.24838491
33SIK31.22263097
34CDC42BPA1.20328737
35SIK21.19503276
36FES1.16902347
37MAP3K141.13456492
38FGFR31.12005157
39MAP3K71.11535950
40CAMK1G1.05973244
41GRK61.04782623
42MTOR1.04629025
43BTK1.04135351
44HCK1.02480864
45JAK10.99436005
46SGK30.99110986
47MAP3K60.98099387
48PRKD20.97218048
49PTK60.96359261
50IRAK20.95773191
51JAK30.93598788
52HIPK20.92648240
53MAP3K20.92625558
54MAPK120.90393626
55FGR0.89955732
56PDPK10.89414992
57TAOK20.85439145
58JAK20.83838726
59CDK40.82439174
60CSF1R0.81291261
61CDK60.80077403
62RET0.79340111
63PDK10.79137479
64MAPK110.75257637
65TBK10.75082973
66YES10.74120302
67IKBKE0.70530835
68IRAK10.69775816
69MAP3K110.68455168
70SYK0.68049783
71SGK20.67692130
72MAPK70.66822919
73PDGFRA0.66621172
74DYRK1B0.66451356
75RPS6KL10.64839127
76RPS6KC10.64839127
77MELK0.62283362
78STK380.59714494
79LRRK20.58432811
80BMX0.56987754
81STK100.56445914
82WNK10.54309732
83PDGFRB0.53944674
84RPS6KA20.53108772
85NLK0.51031923
86ITK0.50492137
87MARK30.48431699
88LCK0.48418256
89PRKAA20.48040393
90TYRO30.46758532
91CAMK40.46114900
92LYN0.46063627
93CHUK0.45254030
94RPS6KA60.44206462
95MAP3K80.41697907
96KSR10.40881763
97MAP2K20.39122226
98RAF10.38584439
99SGK4940.38395815
100SGK2230.38395815

Predicted pathways (KEGG)

RankGene SetZ-score
1Acute myeloid leukemia_Homo sapiens_hsa052212.29509428
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.22249556
3B cell receptor signaling pathway_Homo sapiens_hsa046622.21825881
4Osteoclast differentiation_Homo sapiens_hsa043802.12394585
5Chronic myeloid leukemia_Homo sapiens_hsa052202.01463806
6Non-small cell lung cancer_Homo sapiens_hsa052231.99575542
7Leishmaniasis_Homo sapiens_hsa051401.77838500
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75382384
9Other glycan degradation_Homo sapiens_hsa005111.74792007
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69940585
11Pancreatic cancer_Homo sapiens_hsa052121.65132826
12Notch signaling pathway_Homo sapiens_hsa043301.58817673
13Renal cell carcinoma_Homo sapiens_hsa052111.55891802
14Endometrial cancer_Homo sapiens_hsa052131.55753380
15VEGF signaling pathway_Homo sapiens_hsa043701.51306270
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49736400
17T cell receptor signaling pathway_Homo sapiens_hsa046601.45198978
18Neurotrophin signaling pathway_Homo sapiens_hsa047221.34155579
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33168699
20Tuberculosis_Homo sapiens_hsa051521.32735081
21Hepatitis B_Homo sapiens_hsa051611.30704476
22mTOR signaling pathway_Homo sapiens_hsa041501.30574810
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27212834
24Influenza A_Homo sapiens_hsa051641.26763729
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26300907
26Toxoplasmosis_Homo sapiens_hsa051451.25621036
27Staphylococcus aureus infection_Homo sapiens_hsa051501.25279881
28Measles_Homo sapiens_hsa051621.24493047
29Prostate cancer_Homo sapiens_hsa052151.21779445
30Thyroid cancer_Homo sapiens_hsa052161.21712564
31Prolactin signaling pathway_Homo sapiens_hsa049171.21333513
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21036515
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19748392
34Hepatitis C_Homo sapiens_hsa051601.17946395
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.17193329
36Insulin signaling pathway_Homo sapiens_hsa049101.16763876
37ErbB signaling pathway_Homo sapiens_hsa040121.16613221
38Glioma_Homo sapiens_hsa052141.15220283
39GnRH signaling pathway_Homo sapiens_hsa049121.13711512
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.13661508
41Choline metabolism in cancer_Homo sapiens_hsa052311.11571813
42Colorectal cancer_Homo sapiens_hsa052101.11123626
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10929578
44Inositol phosphate metabolism_Homo sapiens_hsa005621.10660806
45Chemokine signaling pathway_Homo sapiens_hsa040621.10113699
46FoxO signaling pathway_Homo sapiens_hsa040681.10061853
47TNF signaling pathway_Homo sapiens_hsa046681.09817425
48Phospholipase D signaling pathway_Homo sapiens_hsa040721.07520220
49Bladder cancer_Homo sapiens_hsa052191.05960489
50Platelet activation_Homo sapiens_hsa046111.05903245
51Insulin resistance_Homo sapiens_hsa049311.04688209
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03986628
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03382822
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.02282748
55Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00527999
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.98241192
57Malaria_Homo sapiens_hsa051440.97629277
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.95933118
59Herpes simplex infection_Homo sapiens_hsa051680.95736194
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92035308
61Estrogen signaling pathway_Homo sapiens_hsa049150.90540322
62Amoebiasis_Homo sapiens_hsa051460.88929170
63Long-term potentiation_Homo sapiens_hsa047200.88576379
64Apoptosis_Homo sapiens_hsa042100.88207220
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88078547
66Type II diabetes mellitus_Homo sapiens_hsa049300.87267191
67HIF-1 signaling pathway_Homo sapiens_hsa040660.85819436
68Dorso-ventral axis formation_Homo sapiens_hsa043200.85474524
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.84472188
70Viral myocarditis_Homo sapiens_hsa054160.82201664
71Small cell lung cancer_Homo sapiens_hsa052220.81331978
72MicroRNAs in cancer_Homo sapiens_hsa052060.81249289
73Adherens junction_Homo sapiens_hsa045200.79640975
74AMPK signaling pathway_Homo sapiens_hsa041520.75753470
75Lysine degradation_Homo sapiens_hsa003100.75401871
76HTLV-I infection_Homo sapiens_hsa051660.75058393
77Viral carcinogenesis_Homo sapiens_hsa052030.72942622
78Endocytosis_Homo sapiens_hsa041440.72668196
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72361310
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71794703
81Proteoglycans in cancer_Homo sapiens_hsa052050.71688148
82Focal adhesion_Homo sapiens_hsa045100.70195403
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69890367
84MAPK signaling pathway_Homo sapiens_hsa040100.67080476
85Legionellosis_Homo sapiens_hsa051340.63516231
86Hematopoietic cell lineage_Homo sapiens_hsa046400.60268049
87Primary immunodeficiency_Homo sapiens_hsa053400.60055510
88African trypanosomiasis_Homo sapiens_hsa051430.58183392
89Shigellosis_Homo sapiens_hsa051310.57974598
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57881339
91Pertussis_Homo sapiens_hsa051330.57751766
92Prion diseases_Homo sapiens_hsa050200.57703457
93Rap1 signaling pathway_Homo sapiens_hsa040150.57433179
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57215262
95Epstein-Barr virus infection_Homo sapiens_hsa051690.56457258
96Salmonella infection_Homo sapiens_hsa051320.54461207
97Graft-versus-host disease_Homo sapiens_hsa053320.53377296
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53194110
99Lysosome_Homo sapiens_hsa041420.51949047
100Allograft rejection_Homo sapiens_hsa053300.51212010

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