

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit biogenesis (GO:0042274) | 5.75580222 |
| 2 | proteasome assembly (GO:0043248) | 5.27806739 |
| 3 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.16626481 |
| 4 | viral transcription (GO:0019083) | 5.11517430 |
| 5 | ribosomal small subunit assembly (GO:0000028) | 5.11450001 |
| 6 | chaperone-mediated protein transport (GO:0072321) | 5.03822571 |
| 7 | maturation of SSU-rRNA (GO:0030490) | 5.00980860 |
| 8 | translational termination (GO:0006415) | 4.91785339 |
| 9 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.69756240 |
| 10 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.68231777 |
| 11 | ATP synthesis coupled proton transport (GO:0015986) | 4.68231777 |
| 12 | ribosomal large subunit biogenesis (GO:0042273) | 4.66785976 |
| 13 | regulation of mitochondrial translation (GO:0070129) | 4.66620267 |
| 14 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.56739519 |
| 15 | rRNA modification (GO:0000154) | 4.49631774 |
| 16 | cotranslational protein targeting to membrane (GO:0006613) | 4.46367375 |
| 17 | protein targeting to ER (GO:0045047) | 4.45994069 |
| 18 | translational elongation (GO:0006414) | 4.43938965 |
| 19 | protein targeting to mitochondrion (GO:0006626) | 4.42818016 |
| 20 | pseudouridine synthesis (GO:0001522) | 4.35051471 |
| 21 | protein localization to endoplasmic reticulum (GO:0070972) | 4.26297984 |
| 22 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.25278056 |
| 23 | termination of RNA polymerase III transcription (GO:0006386) | 4.24848771 |
| 24 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.24848771 |
| 25 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.22698364 |
| 26 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.22406221 |
| 27 | respiratory electron transport chain (GO:0022904) | 4.20295098 |
| 28 | translational initiation (GO:0006413) | 4.18373678 |
| 29 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.15812857 |
| 30 | translation (GO:0006412) | 4.13421551 |
| 31 | protein complex biogenesis (GO:0070271) | 4.12538495 |
| 32 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.10167040 |
| 33 | establishment of protein localization to mitochondrion (GO:0072655) | 4.09843883 |
| 34 | electron transport chain (GO:0022900) | 4.09540325 |
| 35 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.03914482 |
| 36 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.03914482 |
| 37 | NADH dehydrogenase complex assembly (GO:0010257) | 4.03914482 |
| 38 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.02362371 |
| 39 | rRNA processing (GO:0006364) | 3.99358111 |
| 40 | viral life cycle (GO:0019058) | 3.96093449 |
| 41 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.95620266 |
| 42 | formation of translation preinitiation complex (GO:0001731) | 3.93567952 |
| 43 | cellular component biogenesis (GO:0044085) | 3.92668137 |
| 44 | protein localization to mitochondrion (GO:0070585) | 3.91468374 |
| 45 | cellular protein complex disassembly (GO:0043624) | 3.78809013 |
| 46 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.78346213 |
| 47 | negative regulation of ligase activity (GO:0051352) | 3.78346213 |
| 48 | rRNA metabolic process (GO:0016072) | 3.78343136 |
| 49 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.76816117 |
| 50 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.74426277 |
| 51 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.71395871 |
| 52 | oxidative phosphorylation (GO:0006119) | 3.63503338 |
| 53 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.62874781 |
| 54 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.60464145 |
| 55 | inner mitochondrial membrane organization (GO:0007007) | 3.57726855 |
| 56 | ribosome assembly (GO:0042255) | 3.57483313 |
| 57 | spliceosomal snRNP assembly (GO:0000387) | 3.57123633 |
| 58 | ribosome biogenesis (GO:0042254) | 3.50178063 |
| 59 | transcription from mitochondrial promoter (GO:0006390) | 3.49655932 |
| 60 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.48415974 |
| 61 | maturation of 5.8S rRNA (GO:0000460) | 3.46464123 |
| 62 | GTP biosynthetic process (GO:0006183) | 3.44875486 |
| 63 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.44497832 |
| 64 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.42763773 |
| 65 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.42000711 |
| 66 | rRNA methylation (GO:0031167) | 3.40912686 |
| 67 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.40714491 |
| 68 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.40714491 |
| 69 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.38788153 |
| 70 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.38788153 |
| 71 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.38788153 |
| 72 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.38251034 |
| 73 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.37314430 |
| 74 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.35947190 |
| 75 | metallo-sulfur cluster assembly (GO:0031163) | 3.35388086 |
| 76 | iron-sulfur cluster assembly (GO:0016226) | 3.35388086 |
| 77 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.33574343 |
| 78 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.33574343 |
| 79 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.33545718 |
| 80 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.33249922 |
| 81 | UTP biosynthetic process (GO:0006228) | 3.32018892 |
| 82 | protein complex disassembly (GO:0043241) | 3.30026856 |
| 83 | positive regulation of ligase activity (GO:0051351) | 3.29767012 |
| 84 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.26586576 |
| 85 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.24333460 |
| 86 | peptidyl-histidine modification (GO:0018202) | 3.24090202 |
| 87 | DNA strand elongation (GO:0022616) | 3.23832825 |
| 88 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.19990665 |
| 89 | GDP-mannose metabolic process (GO:0019673) | 3.18663823 |
| 90 | macromolecular complex disassembly (GO:0032984) | 3.17489840 |
| 91 | CTP biosynthetic process (GO:0006241) | 3.12993547 |
| 92 | CTP metabolic process (GO:0046036) | 3.12993547 |
| 93 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.12761311 |
| 94 | viral mRNA export from host cell nucleus (GO:0046784) | 3.12169938 |
| 95 | cullin deneddylation (GO:0010388) | 3.11076871 |
| 96 | respiratory chain complex IV assembly (GO:0008535) | 3.10049010 |
| 97 | mitochondrial transport (GO:0006839) | 3.09590191 |
| 98 | ncRNA processing (GO:0034470) | 3.07648004 |
| 99 | protein maturation by protein folding (GO:0022417) | 3.07208401 |
| 100 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.06820283 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.17587203 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.10666791 |
| 3 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.01036728 |
| 4 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.88379217 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.62696681 |
| 6 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.58175794 |
| 7 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.53589433 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.49302415 |
| 9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.28970373 |
| 10 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.24803416 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.23084464 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.09541825 |
| 13 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.07156319 |
| 14 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.04183276 |
| 15 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.77481079 |
| 16 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.72169199 |
| 17 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.65829720 |
| 18 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.61646970 |
| 19 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.58542313 |
| 20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.53075203 |
| 21 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.46332761 |
| 22 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.34563434 |
| 23 | * GABP_19822575_ChIP-Seq_HepG2_Human | 2.32367686 |
| 24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.22197500 |
| 25 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.20948341 |
| 26 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.18825492 |
| 27 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.17954902 |
| 28 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.17933971 |
| 29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.12905157 |
| 30 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.10009303 |
| 31 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.08757796 |
| 32 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.05805165 |
| 33 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.01216181 |
| 34 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.84124602 |
| 35 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.79426433 |
| 36 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.74557467 |
| 37 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.74199403 |
| 38 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.70759608 |
| 39 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.69167221 |
| 40 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.68145867 |
| 41 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.66971494 |
| 42 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.66722520 |
| 43 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.65641168 |
| 44 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.61953901 |
| 45 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.61140957 |
| 46 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.59352386 |
| 47 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.59349788 |
| 48 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.57082208 |
| 49 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.56813380 |
| 50 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.56361949 |
| 51 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.54992816 |
| 52 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.49291095 |
| 53 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.48985532 |
| 54 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.47436271 |
| 55 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.41916276 |
| 56 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.37291782 |
| 57 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.33872189 |
| 58 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.27667279 |
| 59 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.26597047 |
| 60 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.24811171 |
| 61 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.23893516 |
| 62 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.22460656 |
| 63 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.20804635 |
| 64 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.20248241 |
| 65 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.20157890 |
| 66 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.17803586 |
| 67 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.16315425 |
| 68 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.16041550 |
| 69 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.12670463 |
| 70 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.11280424 |
| 71 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.10738547 |
| 72 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.09696439 |
| 73 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.08753300 |
| 74 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.06454773 |
| 75 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.05713461 |
| 76 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.04612621 |
| 77 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.04229922 |
| 78 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.02559727 |
| 79 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.02003384 |
| 80 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.01381317 |
| 81 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.99322044 |
| 82 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.98324501 |
| 83 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.98113960 |
| 84 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.95792124 |
| 85 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.94906996 |
| 86 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.94262647 |
| 87 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.93093547 |
| 88 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.92228535 |
| 89 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.89793294 |
| 90 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.89684649 |
| 91 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.88962574 |
| 92 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.88495769 |
| 93 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.88428301 |
| 94 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.86847479 |
| 95 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.86475787 |
| 96 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.86382212 |
| 97 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.85470796 |
| 98 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.85045319 |
| 99 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.84387982 |
| 100 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.81551064 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003806_abnormal_nucleotide_metabolis | 5.03193904 |
| 2 | MP0003693_abnormal_embryo_hatching | 4.13104643 |
| 3 | MP0008058_abnormal_DNA_repair | 3.96919218 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.46533448 |
| 5 | MP0004957_abnormal_blastocyst_morpholog | 3.40434058 |
| 6 | MP0003186_abnormal_redox_activity | 3.38893614 |
| 7 | MP0006036_abnormal_mitochondrial_physio | 3.30784619 |
| 8 | MP0009379_abnormal_foot_pigmentation | 3.20081926 |
| 9 | MP0010094_abnormal_chromosome_stability | 3.17137530 |
| 10 | MP0003077_abnormal_cell_cycle | 2.91562695 |
| 11 | MP0003786_premature_aging | 2.83786872 |
| 12 | MP0000372_irregular_coat_pigmentation | 2.74996748 |
| 13 | MP0003718_maternal_effect | 2.58531906 |
| 14 | MP0008932_abnormal_embryonic_tissue | 2.51828553 |
| 15 | MP0006035_abnormal_mitochondrial_morpho | 2.43340591 |
| 16 | MP0009697_abnormal_copulation | 2.27756911 |
| 17 | MP0008007_abnormal_cellular_replicative | 2.12188813 |
| 18 | MP0009333_abnormal_splenocyte_physiolog | 1.98768767 |
| 19 | MP0010030_abnormal_orbit_morphology | 1.85280068 |
| 20 | MP0003315_abnormal_perineum_morphology | 1.82733648 |
| 21 | MP0002234_abnormal_pharynx_morphology | 1.72408041 |
| 22 | MP0000678_abnormal_parathyroid_gland | 1.68232324 |
| 23 | MP0008995_early_reproductive_senescence | 1.63542948 |
| 24 | MP0000358_abnormal_cell_content/ | 1.61346796 |
| 25 | MP0002160_abnormal_reproductive_system | 1.57050979 |
| 26 | MP0001730_embryonic_growth_arrest | 1.54801937 |
| 27 | MP0005451_abnormal_body_composition | 1.52771778 |
| 28 | MP0001764_abnormal_homeostasis | 1.51629976 |
| 29 | MP0000350_abnormal_cell_proliferation | 1.46518463 |
| 30 | MP0002163_abnormal_gland_morphology | 1.41122766 |
| 31 | MP0006292_abnormal_olfactory_placode | 1.40569551 |
| 32 | MP0000749_muscle_degeneration | 1.39091281 |
| 33 | MP0000313_abnormal_cell_death | 1.35571323 |
| 34 | MP0005501_abnormal_skin_physiology | 1.32750558 |
| 35 | MP0001529_abnormal_vocalization | 1.28874415 |
| 36 | MP0002837_dystrophic_cardiac_calcinosis | 1.23916799 |
| 37 | MP0002132_abnormal_respiratory_system | 1.23160842 |
| 38 | MP0001881_abnormal_mammary_gland | 1.22633262 |
| 39 | MP0002210_abnormal_sex_determination | 1.21475097 |
| 40 | MP0001873_stomach_inflammation | 1.20411889 |
| 41 | MP0000049_abnormal_middle_ear | 1.19148623 |
| 42 | MP0005330_cardiomyopathy | 1.16641284 |
| 43 | MP0005360_urolithiasis | 1.16587686 |
| 44 | MP0001905_abnormal_dopamine_level | 1.15770936 |
| 45 | MP0005058_abnormal_lysosome_morphology | 1.12702268 |
| 46 | MP0008789_abnormal_olfactory_epithelium | 1.09725551 |
| 47 | MP0009840_abnormal_foam_cell | 1.09103019 |
| 48 | MP0008260_abnormal_autophagy | 1.08433979 |
| 49 | MP0000490_abnormal_crypts_of | 1.07253854 |
| 50 | MP0005075_abnormal_melanosome_morpholog | 1.05913888 |
| 51 | MP0002080_prenatal_lethality | 1.04603996 |
| 52 | MP0005408_hypopigmentation | 1.04601779 |
| 53 | MP0002277_abnormal_respiratory_mucosa | 1.03364775 |
| 54 | MP0001697_abnormal_embryo_size | 1.02753745 |
| 55 | MP0000537_abnormal_urethra_morphology | 1.02484826 |
| 56 | MP0000750_abnormal_muscle_regeneration | 1.00260527 |
| 57 | MP0001661_extended_life_span | 0.98418279 |
| 58 | MP0001929_abnormal_gametogenesis | 0.97162707 |
| 59 | MP0002019_abnormal_tumor_incidence | 0.95044978 |
| 60 | MP0008875_abnormal_xenobiotic_pharmacok | 0.94614355 |
| 61 | MP0001145_abnormal_male_reproductive | 0.92375064 |
| 62 | MP0004233_abnormal_muscle_weight | 0.92056136 |
| 63 | MP0001672_abnormal_embryogenesis/_devel | 0.90979813 |
| 64 | MP0005380_embryogenesis_phenotype | 0.90979813 |
| 65 | MP0005332_abnormal_amino_acid | 0.88712137 |
| 66 | MP0000653_abnormal_sex_gland | 0.85552531 |
| 67 | MP0005319_abnormal_enzyme/_coenzyme | 0.84475797 |
| 68 | MP0002938_white_spotting | 0.84065588 |
| 69 | MP0001293_anophthalmia | 0.82996482 |
| 70 | MP0005389_reproductive_system_phenotype | 0.82439774 |
| 71 | MP0004147_increased_porphyrin_level | 0.81900493 |
| 72 | MP0002796_impaired_skin_barrier | 0.80688988 |
| 73 | MP0005646_abnormal_pituitary_gland | 0.80255395 |
| 74 | MP0008873_increased_physiological_sensi | 0.76856913 |
| 75 | MP0000343_altered_response_to | 0.74906578 |
| 76 | MP0003984_embryonic_growth_retardation | 0.74299262 |
| 77 | MP0001346_abnormal_lacrimal_gland | 0.73569130 |
| 78 | MP0002269_muscular_atrophy | 0.73555166 |
| 79 | MP0001727_abnormal_embryo_implantation | 0.72036881 |
| 80 | MP0005636_abnormal_mineral_homeostasis | 0.71044182 |
| 81 | MP0005499_abnormal_olfactory_system | 0.70432520 |
| 82 | MP0005394_taste/olfaction_phenotype | 0.70432520 |
| 83 | MP0005266_abnormal_metabolism | 0.69824135 |
| 84 | MP0002085_abnormal_embryonic_tissue | 0.68875427 |
| 85 | MP0002822_catalepsy | 0.68569480 |
| 86 | MP0005410_abnormal_fertilization | 0.68519718 |
| 87 | MP0002088_abnormal_embryonic_growth/wei | 0.67975859 |
| 88 | MP0002148_abnormal_hypersensitivity_rea | 0.67022189 |
| 89 | MP0005084_abnormal_gallbladder_morpholo | 0.65297773 |
| 90 | MP0005379_endocrine/exocrine_gland_phen | 0.60881637 |
| 91 | MP0003136_yellow_coat_color | 0.57515710 |
| 92 | MP0000681_abnormal_thyroid_gland | 0.57068885 |
| 93 | MP0002736_abnormal_nociception_after | 0.56635320 |
| 94 | MP0001853_heart_inflammation | 0.56340296 |
| 95 | MP0001919_abnormal_reproductive_system | 0.56262171 |
| 96 | MP0003646_muscle_fatigue | 0.55943229 |
| 97 | MP0003698_abnormal_male_reproductive | 0.55298112 |
| 98 | MP0003283_abnormal_digestive_organ | 0.54298545 |
| 99 | MP0002161_abnormal_fertility/fecundity | 0.54163103 |
| 100 | MP0008057_abnormal_DNA_replication | 0.53348226 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.70399553 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.66286672 |
| 3 | Mitochondrial inheritance (HP:0001427) | 5.23109058 |
| 4 | Acute encephalopathy (HP:0006846) | 5.07436234 |
| 5 | Increased CSF lactate (HP:0002490) | 4.98749585 |
| 6 | Hepatocellular necrosis (HP:0001404) | 4.85263199 |
| 7 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.71052653 |
| 8 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.71052653 |
| 9 | Hepatic necrosis (HP:0002605) | 4.52944612 |
| 10 | Progressive macrocephaly (HP:0004481) | 4.45929366 |
| 11 | Increased hepatocellular lipid droplets (HP:0006565) | 4.12706098 |
| 12 | Abnormal number of erythroid precursors (HP:0012131) | 4.09189578 |
| 13 | Increased intramyocellular lipid droplets (HP:0012240) | 4.08364220 |
| 14 | Renal Fanconi syndrome (HP:0001994) | 4.05183024 |
| 15 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.97836080 |
| 16 | Lipid accumulation in hepatocytes (HP:0006561) | 3.97425332 |
| 17 | Cerebral edema (HP:0002181) | 3.85342275 |
| 18 | Increased serum lactate (HP:0002151) | 3.75695180 |
| 19 | Increased muscle lipid content (HP:0009058) | 3.71551796 |
| 20 | Type I transferrin isoform profile (HP:0003642) | 3.67090131 |
| 21 | Lactic acidosis (HP:0003128) | 3.60234089 |
| 22 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.48570492 |
| 23 | Exercise intolerance (HP:0003546) | 3.40460993 |
| 24 | Microvesicular hepatic steatosis (HP:0001414) | 3.37123008 |
| 25 | Reduced antithrombin III activity (HP:0001976) | 3.29531301 |
| 26 | Reticulocytopenia (HP:0001896) | 3.26925861 |
| 27 | Respiratory failure (HP:0002878) | 3.16834525 |
| 28 | Abnormal protein glycosylation (HP:0012346) | 3.15824218 |
| 29 | Abnormal glycosylation (HP:0012345) | 3.15824218 |
| 30 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 3.15824218 |
| 31 | Abnormal protein N-linked glycosylation (HP:0012347) | 3.15824218 |
| 32 | Macrocytic anemia (HP:0001972) | 3.13144157 |
| 33 | Aplastic anemia (HP:0001915) | 3.09037774 |
| 34 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.99120038 |
| 35 | Rough bone trabeculation (HP:0100670) | 2.98141820 |
| 36 | Increased serum pyruvate (HP:0003542) | 2.96111032 |
| 37 | Testicular atrophy (HP:0000029) | 2.89373342 |
| 38 | 3-Methylglutaconic aciduria (HP:0003535) | 2.88519870 |
| 39 | Progressive muscle weakness (HP:0003323) | 2.86330209 |
| 40 | Respiratory difficulties (HP:0002880) | 2.85835996 |
| 41 | Abnormality of glycolysis (HP:0004366) | 2.84618853 |
| 42 | Generalized aminoaciduria (HP:0002909) | 2.76456777 |
| 43 | Cerebral hypomyelination (HP:0006808) | 2.73360698 |
| 44 | Microretrognathia (HP:0000308) | 2.70634809 |
| 45 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.66550964 |
| 46 | Ragged-red muscle fibers (HP:0003200) | 2.66528512 |
| 47 | Exertional dyspnea (HP:0002875) | 2.65275477 |
| 48 | Multiple enchondromatosis (HP:0005701) | 2.45990660 |
| 49 | Lethargy (HP:0001254) | 2.43743002 |
| 50 | Emotional lability (HP:0000712) | 2.40132111 |
| 51 | Pallor (HP:0000980) | 2.31864744 |
| 52 | Leukodystrophy (HP:0002415) | 2.31598124 |
| 53 | Optic disc pallor (HP:0000543) | 2.28996309 |
| 54 | Oral leukoplakia (HP:0002745) | 2.25216685 |
| 55 | Abnormal trabecular bone morphology (HP:0100671) | 2.23398884 |
| 56 | Abnormality of alanine metabolism (HP:0010916) | 2.21292954 |
| 57 | Hyperalaninemia (HP:0003348) | 2.21292954 |
| 58 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.21292954 |
| 59 | Abnormality of renal resorption (HP:0011038) | 2.19670397 |
| 60 | Cleft eyelid (HP:0000625) | 2.15846121 |
| 61 | Muscle fiber atrophy (HP:0100295) | 2.15600671 |
| 62 | Opisthotonus (HP:0002179) | 2.15129666 |
| 63 | CNS demyelination (HP:0007305) | 2.15055159 |
| 64 | Dicarboxylic aciduria (HP:0003215) | 2.14648792 |
| 65 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.14648792 |
| 66 | Pancytopenia (HP:0001876) | 2.13242815 |
| 67 | Degeneration of anterior horn cells (HP:0002398) | 2.12755757 |
| 68 | Abnormality of the anterior horn cell (HP:0006802) | 2.12755757 |
| 69 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.09167391 |
| 70 | Sparse eyelashes (HP:0000653) | 2.03085027 |
| 71 | Glycosuria (HP:0003076) | 2.00252157 |
| 72 | Abnormality of urine glucose concentration (HP:0011016) | 2.00252157 |
| 73 | Premature ovarian failure (HP:0008209) | 1.98829799 |
| 74 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.96466177 |
| 75 | Hypokinesia (HP:0002375) | 1.96079039 |
| 76 | Trismus (HP:0000211) | 1.94053786 |
| 77 | Type 2 muscle fiber atrophy (HP:0003554) | 1.91217461 |
| 78 | Redundant skin (HP:0001582) | 1.88902560 |
| 79 | Abnormal gallbladder physiology (HP:0012438) | 1.87630529 |
| 80 | Cholecystitis (HP:0001082) | 1.87630529 |
| 81 | Methylmalonic aciduria (HP:0012120) | 1.85555746 |
| 82 | Secondary amenorrhea (HP:0000869) | 1.83700004 |
| 83 | Myopathic facies (HP:0002058) | 1.83506114 |
| 84 | Gout (HP:0001997) | 1.82394691 |
| 85 | X-linked dominant inheritance (HP:0001423) | 1.80846908 |
| 86 | Hypergonadotropic hypogonadism (HP:0000815) | 1.79357791 |
| 87 | Death in infancy (HP:0001522) | 1.76518595 |
| 88 | Absent thumb (HP:0009777) | 1.75254685 |
| 89 | Hypoplasia of the uterus (HP:0000013) | 1.73998085 |
| 90 | Sensory axonal neuropathy (HP:0003390) | 1.72674748 |
| 91 | Abnormality of placental membranes (HP:0011409) | 1.69716731 |
| 92 | Amniotic constriction ring (HP:0009775) | 1.69716731 |
| 93 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.65509408 |
| 94 | Horseshoe kidney (HP:0000085) | 1.65323332 |
| 95 | Hyperphosphaturia (HP:0003109) | 1.65080050 |
| 96 | Vomiting (HP:0002013) | 1.64740918 |
| 97 | Facial cleft (HP:0002006) | 1.61076356 |
| 98 | Blindness (HP:0000618) | 1.59314775 |
| 99 | Truncus arteriosus (HP:0001660) | 1.58319305 |
| 100 | Abnormality of the preputium (HP:0100587) | 1.58257240 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME2 | 5.98609385 |
| 2 | VRK2 | 5.11582198 |
| 3 | BUB1 | 4.56714248 |
| 4 | PBK | 3.05018587 |
| 5 | BCKDK | 3.02211894 |
| 6 | STK16 | 2.62134628 |
| 7 | SRPK1 | 2.42777852 |
| 8 | NME1 | 2.24008665 |
| 9 | PIM2 | 2.22183419 |
| 10 | TESK2 | 2.11770806 |
| 11 | CDC7 | 2.10153195 |
| 12 | NEK1 | 2.05957931 |
| 13 | VRK1 | 1.93259562 |
| 14 | ARAF | 1.84641382 |
| 15 | IRAK3 | 1.81698943 |
| 16 | EIF2AK1 | 1.80575378 |
| 17 | ZAK | 1.71037278 |
| 18 | TESK1 | 1.71013501 |
| 19 | KDR | 1.63897386 |
| 20 | PDK2 | 1.61247484 |
| 21 | ABL2 | 1.49501115 |
| 22 | PLK4 | 1.33403788 |
| 23 | AURKA | 1.31336022 |
| 24 | TSSK6 | 1.28130371 |
| 25 | SMG1 | 1.25743723 |
| 26 | SCYL2 | 1.24995227 |
| 27 | CSNK1G3 | 1.22691930 |
| 28 | TAF1 | 1.22363645 |
| 29 | EIF2AK3 | 1.20200870 |
| 30 | PLK1 | 1.12856211 |
| 31 | ILK | 1.12355914 |
| 32 | TLK1 | 1.11149471 |
| 33 | TRIM28 | 1.10348086 |
| 34 | TTK | 1.08928258 |
| 35 | CHEK2 | 1.07816449 |
| 36 | AURKB | 1.06292985 |
| 37 | TAOK2 | 1.05318992 |
| 38 | CDK8 | 1.03503375 |
| 39 | WEE1 | 1.02956135 |
| 40 | RPS6KA5 | 1.00860762 |
| 41 | BRSK1 | 1.00845457 |
| 42 | BRAF | 0.99438671 |
| 43 | DAPK3 | 0.98037462 |
| 44 | DAPK1 | 0.95327802 |
| 45 | EPHA2 | 0.93142737 |
| 46 | MAP4K2 | 0.92714955 |
| 47 | PLK3 | 0.89858467 |
| 48 | LRRK2 | 0.88287539 |
| 49 | CSNK1A1L | 0.85540329 |
| 50 | CSNK1G1 | 0.84648315 |
| 51 | CDK7 | 0.84434341 |
| 52 | NUAK1 | 0.84153485 |
| 53 | STK4 | 0.83017339 |
| 54 | MAP2K7 | 0.81578232 |
| 55 | LIMK1 | 0.78514065 |
| 56 | ATR | 0.78489521 |
| 57 | CSNK2A1 | 0.76828115 |
| 58 | CSNK2A2 | 0.76700649 |
| 59 | PINK1 | 0.75573513 |
| 60 | RPS6KA4 | 0.74730864 |
| 61 | MAP3K12 | 0.74617849 |
| 62 | MST4 | 0.74534095 |
| 63 | MARK3 | 0.72069481 |
| 64 | MAP3K8 | 0.71128357 |
| 65 | MUSK | 0.69677494 |
| 66 | PRKCI | 0.69560323 |
| 67 | CSNK1G2 | 0.69119137 |
| 68 | MAP3K11 | 0.68793541 |
| 69 | PAK1 | 0.68770761 |
| 70 | PAK4 | 0.66341077 |
| 71 | RPS6KB2 | 0.64853443 |
| 72 | DYRK2 | 0.64679957 |
| 73 | CHEK1 | 0.62700419 |
| 74 | DYRK3 | 0.61875788 |
| 75 | CAMK2G | 0.61113867 |
| 76 | AKT2 | 0.58247257 |
| 77 | CDK19 | 0.56360355 |
| 78 | IKBKB | 0.55080841 |
| 79 | IRAK2 | 0.54697349 |
| 80 | CCNB1 | 0.44896771 |
| 81 | BRSK2 | 0.42941374 |
| 82 | FLT3 | 0.38289453 |
| 83 | MAP3K5 | 0.36177169 |
| 84 | EIF2AK2 | 0.35950857 |
| 85 | MYLK | 0.34519030 |
| 86 | ATM | 0.33758915 |
| 87 | CDK4 | 0.33091879 |
| 88 | SIK3 | 0.32924346 |
| 89 | OBSCN | 0.32845268 |
| 90 | TBK1 | 0.31915737 |
| 91 | BMX | 0.30779664 |
| 92 | MAPKAPK5 | 0.28924410 |
| 93 | MAPKAPK3 | 0.28375700 |
| 94 | STK10 | 0.27405704 |
| 95 | CSNK1A1 | 0.27123995 |
| 96 | CDK2 | 0.26696905 |
| 97 | MST1R | 0.26117259 |
| 98 | MAP3K3 | 0.25295773 |
| 99 | CAMK2D | 0.25234257 |
| 100 | RAF1 | 0.24424531 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.91133664 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.41034855 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.63889661 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 3.44557532 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.30997700 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 3.23946574 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.11413538 |
| 8 | Mismatch repair_Homo sapiens_hsa03430 | 2.73613603 |
| 9 | Sulfur relay system_Homo sapiens_hsa04122 | 2.71414467 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.56124898 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.41519123 |
| 12 | Huntingtons disease_Homo sapiens_hsa05016 | 2.39899736 |
| 13 | Spliceosome_Homo sapiens_hsa03040 | 2.28872530 |
| 14 | Homologous recombination_Homo sapiens_hsa03440 | 2.07475717 |
| 15 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.00957158 |
| 16 | Alzheimers disease_Homo sapiens_hsa05010 | 1.99430974 |
| 17 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.84655858 |
| 18 | RNA transport_Homo sapiens_hsa03013 | 1.75111576 |
| 19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.74074105 |
| 20 | Protein export_Homo sapiens_hsa03060 | 1.71486206 |
| 21 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.61039810 |
| 22 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.58228307 |
| 23 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.53952287 |
| 24 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.52410311 |
| 25 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.37825222 |
| 26 | Purine metabolism_Homo sapiens_hsa00230 | 1.35725106 |
| 27 | RNA degradation_Homo sapiens_hsa03018 | 1.33290353 |
| 28 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.32972607 |
| 29 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.27502111 |
| 30 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.27342162 |
| 31 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.24121212 |
| 32 | Basal transcription factors_Homo sapiens_hsa03022 | 1.23578952 |
| 33 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.23100094 |
| 34 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.22559134 |
| 35 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.20540485 |
| 36 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.14970412 |
| 37 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.12157600 |
| 38 | Carbon metabolism_Homo sapiens_hsa01200 | 1.05998067 |
| 39 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.02903189 |
| 40 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.01852777 |
| 41 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.97867103 |
| 42 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.97027910 |
| 43 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.96880373 |
| 44 | Cell cycle_Homo sapiens_hsa04110 | 0.96073493 |
| 45 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.92347530 |
| 46 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.91097430 |
| 47 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.90393728 |
| 48 | Metabolic pathways_Homo sapiens_hsa01100 | 0.87323603 |
| 49 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.86935591 |
| 50 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.81855990 |
| 51 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.80605710 |
| 52 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.73275960 |
| 53 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.70267090 |
| 54 | Peroxisome_Homo sapiens_hsa04146 | 0.69542425 |
| 55 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.68265631 |
| 56 | Galactose metabolism_Homo sapiens_hsa00052 | 0.65735898 |
| 57 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.63686228 |
| 58 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.60547280 |
| 59 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.58931450 |
| 60 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.57658179 |
| 61 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.53904041 |
| 62 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.53107892 |
| 63 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.52149165 |
| 64 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.49899619 |
| 65 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.49707456 |
| 66 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.49311017 |
| 67 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.47918193 |
| 68 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.47853615 |
| 69 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.46100774 |
| 70 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.45652126 |
| 71 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.41644323 |
| 72 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.39317839 |
| 73 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.38744424 |
| 74 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.38339412 |
| 75 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.36047439 |
| 76 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.33777166 |
| 77 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.33591594 |
| 78 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.31908779 |
| 79 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.28946921 |
| 80 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.27679775 |
| 81 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.22076269 |
| 82 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.20841030 |
| 83 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.19219703 |
| 84 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.15985109 |
| 85 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.15972822 |
| 86 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.14029851 |
| 87 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.11923252 |
| 88 | Shigellosis_Homo sapiens_hsa05131 | 0.11835559 |
| 89 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.10979307 |
| 90 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.08919506 |
| 91 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.08907681 |
| 92 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.07932290 |
| 93 | Alcoholism_Homo sapiens_hsa05034 | 0.07256703 |
| 94 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.07249620 |
| 95 | Bladder cancer_Homo sapiens_hsa05219 | 0.06611200 |
| 96 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.06599560 |
| 97 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.05131714 |
| 98 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.05120275 |
| 99 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.04739981 |
| 100 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.04538015 |

