ZNF593

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.75580222
2proteasome assembly (GO:0043248)5.27806739
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.16626481
4viral transcription (GO:0019083)5.11517430
5ribosomal small subunit assembly (GO:0000028)5.11450001
6chaperone-mediated protein transport (GO:0072321)5.03822571
7maturation of SSU-rRNA (GO:0030490)5.00980860
8translational termination (GO:0006415)4.91785339
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.69756240
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.68231777
11ATP synthesis coupled proton transport (GO:0015986)4.68231777
12ribosomal large subunit biogenesis (GO:0042273)4.66785976
13regulation of mitochondrial translation (GO:0070129)4.66620267
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.56739519
15rRNA modification (GO:0000154)4.49631774
16cotranslational protein targeting to membrane (GO:0006613)4.46367375
17protein targeting to ER (GO:0045047)4.45994069
18translational elongation (GO:0006414)4.43938965
19protein targeting to mitochondrion (GO:0006626)4.42818016
20pseudouridine synthesis (GO:0001522)4.35051471
21protein localization to endoplasmic reticulum (GO:0070972)4.26297984
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.25278056
23termination of RNA polymerase III transcription (GO:0006386)4.24848771
24transcription elongation from RNA polymerase III promoter (GO:0006385)4.24848771
25deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.22698364
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.22406221
27respiratory electron transport chain (GO:0022904)4.20295098
28translational initiation (GO:0006413)4.18373678
29ribonucleoprotein complex biogenesis (GO:0022613)4.15812857
30translation (GO:0006412)4.13421551
31protein complex biogenesis (GO:0070271)4.12538495
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.10167040
33establishment of protein localization to mitochondrion (GO:0072655)4.09843883
34electron transport chain (GO:0022900)4.09540325
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.03914482
36mitochondrial respiratory chain complex I assembly (GO:0032981)4.03914482
37NADH dehydrogenase complex assembly (GO:0010257)4.03914482
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.02362371
39rRNA processing (GO:0006364)3.99358111
40viral life cycle (GO:0019058)3.96093449
41mitochondrial respiratory chain complex assembly (GO:0033108)3.95620266
42formation of translation preinitiation complex (GO:0001731)3.93567952
43cellular component biogenesis (GO:0044085)3.92668137
44protein localization to mitochondrion (GO:0070585)3.91468374
45cellular protein complex disassembly (GO:0043624)3.78809013
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.78346213
47negative regulation of ligase activity (GO:0051352)3.78346213
48rRNA metabolic process (GO:0016072)3.78343136
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76816117
50regulation of cellular amino acid metabolic process (GO:0006521)3.74426277
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.71395871
52oxidative phosphorylation (GO:0006119)3.63503338
53pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.62874781
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.60464145
55inner mitochondrial membrane organization (GO:0007007)3.57726855
56ribosome assembly (GO:0042255)3.57483313
57spliceosomal snRNP assembly (GO:0000387)3.57123633
58ribosome biogenesis (GO:0042254)3.50178063
59transcription from mitochondrial promoter (GO:0006390)3.49655932
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.48415974
61maturation of 5.8S rRNA (GO:0000460)3.46464123
62GTP biosynthetic process (GO:0006183)3.44875486
63positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.44497832
64pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.42763773
65guanosine-containing compound biosynthetic process (GO:1901070)3.42000711
66rRNA methylation (GO:0031167)3.40912686
67signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.40714491
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.40714491
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.38788153
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.38788153
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.38788153
72nucleobase-containing small molecule interconversion (GO:0015949)3.38251034
73pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.37314430
74telomere maintenance via semi-conservative replication (GO:0032201)3.35947190
75metallo-sulfur cluster assembly (GO:0031163)3.35388086
76iron-sulfur cluster assembly (GO:0016226)3.35388086
77signal transduction involved in DNA integrity checkpoint (GO:0072401)3.33574343
78signal transduction involved in DNA damage checkpoint (GO:0072422)3.33574343
79DNA strand elongation involved in DNA replication (GO:0006271)3.33545718
80pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.33249922
81UTP biosynthetic process (GO:0006228)3.32018892
82protein complex disassembly (GO:0043241)3.30026856
83positive regulation of ligase activity (GO:0051351)3.29767012
84signal transduction involved in cell cycle checkpoint (GO:0072395)3.26586576
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24333460
86peptidyl-histidine modification (GO:0018202)3.24090202
87DNA strand elongation (GO:0022616)3.23832825
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19990665
89GDP-mannose metabolic process (GO:0019673)3.18663823
90macromolecular complex disassembly (GO:0032984)3.17489840
91CTP biosynthetic process (GO:0006241)3.12993547
92CTP metabolic process (GO:0046036)3.12993547
93transcription-coupled nucleotide-excision repair (GO:0006283)3.12761311
94viral mRNA export from host cell nucleus (GO:0046784)3.12169938
95cullin deneddylation (GO:0010388)3.11076871
96respiratory chain complex IV assembly (GO:0008535)3.10049010
97mitochondrial transport (GO:0006839)3.09590191
98ncRNA processing (GO:0034470)3.07648004
99protein maturation by protein folding (GO:0022417)3.07208401
100regulation of ubiquitin-protein transferase activity (GO:0051438)3.06820283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.17587203
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10666791
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.01036728
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.88379217
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.62696681
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.58175794
7E2F7_22180533_ChIP-Seq_HELA_Human3.53589433
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.49302415
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.28970373
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.24803416
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.23084464
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.09541825
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.07156319
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.04183276
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77481079
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.72169199
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65829720
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61646970
19* XRN2_22483619_ChIP-Seq_HELA_Human2.58542313
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53075203
21DCP1A_22483619_ChIP-Seq_HELA_Human2.46332761
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34563434
23* GABP_19822575_ChIP-Seq_HepG2_Human2.32367686
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22197500
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.20948341
26VDR_23849224_ChIP-Seq_CD4+_Human2.18825492
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17954902
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17933971
29FOXP3_21729870_ChIP-Seq_TREG_Human2.12905157
30TTF2_22483619_ChIP-Seq_HELA_Human2.10009303
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.08757796
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05805165
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.01216181
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84124602
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79426433
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.74557467
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74199403
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70759608
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69167221
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.68145867
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66971494
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66722520
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65641168
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61953901
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61140957
46KDM5A_27292631_Chip-Seq_BREAST_Human1.59352386
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59349788
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57082208
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56813380
50ZNF263_19887448_ChIP-Seq_K562_Human1.56361949
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54992816
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49291095
53ELK1_19687146_ChIP-ChIP_HELA_Human1.48985532
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47436271
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41916276
56BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37291782
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33872189
58CTCF_18555785_ChIP-Seq_MESCs_Mouse1.27667279
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26597047
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24811171
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23893516
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22460656
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20804635
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.20248241
65VDR_21846776_ChIP-Seq_THP-1_Human1.20157890
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17803586
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.16315425
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16041550
69* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12670463
70MYC_18940864_ChIP-ChIP_HL60_Human1.11280424
71FOXP1_21924763_ChIP-Seq_HESCs_Human1.10738547
72FOXM1_23109430_ChIP-Seq_U2OS_Human1.09696439
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08753300
74CIITA_25753668_ChIP-Seq_RAJI_Human1.06454773
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05713461
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04612621
77BP1_19119308_ChIP-ChIP_Hs578T_Human1.04229922
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02559727
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02003384
80TFEB_21752829_ChIP-Seq_HELA_Human1.01381317
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99322044
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98324501
83STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98113960
84TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95792124
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94906996
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94262647
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93093547
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.92228535
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.89793294
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89684649
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88962574
92PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88495769
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.88428301
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86847479
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86475787
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86382212
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85470796
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85045319
99CTCF_26484167_Chip-Seq_Bcells_Mouse0.84387982
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81551064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.03193904
2MP0003693_abnormal_embryo_hatching4.13104643
3MP0008058_abnormal_DNA_repair3.96919218
4MP0003111_abnormal_nucleus_morphology3.46533448
5MP0004957_abnormal_blastocyst_morpholog3.40434058
6MP0003186_abnormal_redox_activity3.38893614
7MP0006036_abnormal_mitochondrial_physio3.30784619
8MP0009379_abnormal_foot_pigmentation3.20081926
9MP0010094_abnormal_chromosome_stability3.17137530
10MP0003077_abnormal_cell_cycle2.91562695
11MP0003786_premature_aging2.83786872
12MP0000372_irregular_coat_pigmentation2.74996748
13MP0003718_maternal_effect2.58531906
14MP0008932_abnormal_embryonic_tissue2.51828553
15MP0006035_abnormal_mitochondrial_morpho2.43340591
16MP0009697_abnormal_copulation2.27756911
17MP0008007_abnormal_cellular_replicative2.12188813
18MP0009333_abnormal_splenocyte_physiolog1.98768767
19MP0010030_abnormal_orbit_morphology1.85280068
20MP0003315_abnormal_perineum_morphology1.82733648
21MP0002234_abnormal_pharynx_morphology1.72408041
22MP0000678_abnormal_parathyroid_gland1.68232324
23MP0008995_early_reproductive_senescence1.63542948
24MP0000358_abnormal_cell_content/1.61346796
25MP0002160_abnormal_reproductive_system1.57050979
26MP0001730_embryonic_growth_arrest1.54801937
27MP0005451_abnormal_body_composition1.52771778
28MP0001764_abnormal_homeostasis1.51629976
29MP0000350_abnormal_cell_proliferation1.46518463
30MP0002163_abnormal_gland_morphology1.41122766
31MP0006292_abnormal_olfactory_placode1.40569551
32MP0000749_muscle_degeneration1.39091281
33MP0000313_abnormal_cell_death1.35571323
34MP0005501_abnormal_skin_physiology1.32750558
35MP0001529_abnormal_vocalization1.28874415
36MP0002837_dystrophic_cardiac_calcinosis1.23916799
37MP0002132_abnormal_respiratory_system1.23160842
38MP0001881_abnormal_mammary_gland1.22633262
39MP0002210_abnormal_sex_determination1.21475097
40MP0001873_stomach_inflammation1.20411889
41MP0000049_abnormal_middle_ear1.19148623
42MP0005330_cardiomyopathy1.16641284
43MP0005360_urolithiasis1.16587686
44MP0001905_abnormal_dopamine_level1.15770936
45MP0005058_abnormal_lysosome_morphology1.12702268
46MP0008789_abnormal_olfactory_epithelium1.09725551
47MP0009840_abnormal_foam_cell1.09103019
48MP0008260_abnormal_autophagy1.08433979
49MP0000490_abnormal_crypts_of1.07253854
50MP0005075_abnormal_melanosome_morpholog1.05913888
51MP0002080_prenatal_lethality1.04603996
52MP0005408_hypopigmentation1.04601779
53MP0002277_abnormal_respiratory_mucosa1.03364775
54MP0001697_abnormal_embryo_size1.02753745
55MP0000537_abnormal_urethra_morphology1.02484826
56MP0000750_abnormal_muscle_regeneration1.00260527
57MP0001661_extended_life_span0.98418279
58MP0001929_abnormal_gametogenesis0.97162707
59MP0002019_abnormal_tumor_incidence0.95044978
60MP0008875_abnormal_xenobiotic_pharmacok0.94614355
61MP0001145_abnormal_male_reproductive0.92375064
62MP0004233_abnormal_muscle_weight0.92056136
63MP0001672_abnormal_embryogenesis/_devel0.90979813
64MP0005380_embryogenesis_phenotype0.90979813
65MP0005332_abnormal_amino_acid0.88712137
66MP0000653_abnormal_sex_gland0.85552531
67MP0005319_abnormal_enzyme/_coenzyme0.84475797
68MP0002938_white_spotting0.84065588
69MP0001293_anophthalmia0.82996482
70MP0005389_reproductive_system_phenotype0.82439774
71MP0004147_increased_porphyrin_level0.81900493
72MP0002796_impaired_skin_barrier0.80688988
73MP0005646_abnormal_pituitary_gland0.80255395
74MP0008873_increased_physiological_sensi0.76856913
75MP0000343_altered_response_to0.74906578
76MP0003984_embryonic_growth_retardation0.74299262
77MP0001346_abnormal_lacrimal_gland0.73569130
78MP0002269_muscular_atrophy0.73555166
79MP0001727_abnormal_embryo_implantation0.72036881
80MP0005636_abnormal_mineral_homeostasis0.71044182
81MP0005499_abnormal_olfactory_system0.70432520
82MP0005394_taste/olfaction_phenotype0.70432520
83MP0005266_abnormal_metabolism0.69824135
84MP0002085_abnormal_embryonic_tissue0.68875427
85MP0002822_catalepsy0.68569480
86MP0005410_abnormal_fertilization0.68519718
87MP0002088_abnormal_embryonic_growth/wei0.67975859
88MP0002148_abnormal_hypersensitivity_rea0.67022189
89MP0005084_abnormal_gallbladder_morpholo0.65297773
90MP0005379_endocrine/exocrine_gland_phen0.60881637
91MP0003136_yellow_coat_color0.57515710
92MP0000681_abnormal_thyroid_gland0.57068885
93MP0002736_abnormal_nociception_after0.56635320
94MP0001853_heart_inflammation0.56340296
95MP0001919_abnormal_reproductive_system0.56262171
96MP0003646_muscle_fatigue0.55943229
97MP0003698_abnormal_male_reproductive0.55298112
98MP0003283_abnormal_digestive_organ0.54298545
99MP0002161_abnormal_fertility/fecundity0.54163103
100MP0008057_abnormal_DNA_replication0.53348226

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.70399553
2Abnormal mitochondria in muscle tissue (HP:0008316)5.66286672
3Mitochondrial inheritance (HP:0001427)5.23109058
4Acute encephalopathy (HP:0006846)5.07436234
5Increased CSF lactate (HP:0002490)4.98749585
6Hepatocellular necrosis (HP:0001404)4.85263199
7Decreased activity of mitochondrial respiratory chain (HP:0008972)4.71052653
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.71052653
9Hepatic necrosis (HP:0002605)4.52944612
10Progressive macrocephaly (HP:0004481)4.45929366
11Increased hepatocellular lipid droplets (HP:0006565)4.12706098
12Abnormal number of erythroid precursors (HP:0012131)4.09189578
13Increased intramyocellular lipid droplets (HP:0012240)4.08364220
14Renal Fanconi syndrome (HP:0001994)4.05183024
15Abnormality of cells of the erythroid lineage (HP:0012130)3.97836080
16Lipid accumulation in hepatocytes (HP:0006561)3.97425332
17Cerebral edema (HP:0002181)3.85342275
18Increased serum lactate (HP:0002151)3.75695180
19Increased muscle lipid content (HP:0009058)3.71551796
20Type I transferrin isoform profile (HP:0003642)3.67090131
21Lactic acidosis (HP:0003128)3.60234089
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.48570492
23Exercise intolerance (HP:0003546)3.40460993
24Microvesicular hepatic steatosis (HP:0001414)3.37123008
25Reduced antithrombin III activity (HP:0001976)3.29531301
26Reticulocytopenia (HP:0001896)3.26925861
27Respiratory failure (HP:0002878)3.16834525
28Abnormal protein glycosylation (HP:0012346)3.15824218
29Abnormal glycosylation (HP:0012345)3.15824218
30Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.15824218
31Abnormal protein N-linked glycosylation (HP:0012347)3.15824218
32Macrocytic anemia (HP:0001972)3.13144157
33Aplastic anemia (HP:0001915)3.09037774
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.99120038
35Rough bone trabeculation (HP:0100670)2.98141820
36Increased serum pyruvate (HP:0003542)2.96111032
37Testicular atrophy (HP:0000029)2.89373342
383-Methylglutaconic aciduria (HP:0003535)2.88519870
39Progressive muscle weakness (HP:0003323)2.86330209
40Respiratory difficulties (HP:0002880)2.85835996
41Abnormality of glycolysis (HP:0004366)2.84618853
42Generalized aminoaciduria (HP:0002909)2.76456777
43Cerebral hypomyelination (HP:0006808)2.73360698
44Microretrognathia (HP:0000308)2.70634809
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.66550964
46Ragged-red muscle fibers (HP:0003200)2.66528512
47Exertional dyspnea (HP:0002875)2.65275477
48Multiple enchondromatosis (HP:0005701)2.45990660
49Lethargy (HP:0001254)2.43743002
50Emotional lability (HP:0000712)2.40132111
51Pallor (HP:0000980)2.31864744
52Leukodystrophy (HP:0002415)2.31598124
53Optic disc pallor (HP:0000543)2.28996309
54Oral leukoplakia (HP:0002745)2.25216685
55Abnormal trabecular bone morphology (HP:0100671)2.23398884
56Abnormality of alanine metabolism (HP:0010916)2.21292954
57Hyperalaninemia (HP:0003348)2.21292954
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21292954
59Abnormality of renal resorption (HP:0011038)2.19670397
60Cleft eyelid (HP:0000625)2.15846121
61Muscle fiber atrophy (HP:0100295)2.15600671
62Opisthotonus (HP:0002179)2.15129666
63CNS demyelination (HP:0007305)2.15055159
64Dicarboxylic aciduria (HP:0003215)2.14648792
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14648792
66Pancytopenia (HP:0001876)2.13242815
67Degeneration of anterior horn cells (HP:0002398)2.12755757
68Abnormality of the anterior horn cell (HP:0006802)2.12755757
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09167391
70Sparse eyelashes (HP:0000653)2.03085027
71Glycosuria (HP:0003076)2.00252157
72Abnormality of urine glucose concentration (HP:0011016)2.00252157
73Premature ovarian failure (HP:0008209)1.98829799
74Aplasia/hypoplasia of the uterus (HP:0008684)1.96466177
75Hypokinesia (HP:0002375)1.96079039
76Trismus (HP:0000211)1.94053786
77Type 2 muscle fiber atrophy (HP:0003554)1.91217461
78Redundant skin (HP:0001582)1.88902560
79Abnormal gallbladder physiology (HP:0012438)1.87630529
80Cholecystitis (HP:0001082)1.87630529
81Methylmalonic aciduria (HP:0012120)1.85555746
82Secondary amenorrhea (HP:0000869)1.83700004
83Myopathic facies (HP:0002058)1.83506114
84Gout (HP:0001997)1.82394691
85X-linked dominant inheritance (HP:0001423)1.80846908
86Hypergonadotropic hypogonadism (HP:0000815)1.79357791
87Death in infancy (HP:0001522)1.76518595
88Absent thumb (HP:0009777)1.75254685
89Hypoplasia of the uterus (HP:0000013)1.73998085
90Sensory axonal neuropathy (HP:0003390)1.72674748
91Abnormality of placental membranes (HP:0011409)1.69716731
92Amniotic constriction ring (HP:0009775)1.69716731
93Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.65509408
94Horseshoe kidney (HP:0000085)1.65323332
95Hyperphosphaturia (HP:0003109)1.65080050
96Vomiting (HP:0002013)1.64740918
97Facial cleft (HP:0002006)1.61076356
98Blindness (HP:0000618)1.59314775
99Truncus arteriosus (HP:0001660)1.58319305
100Abnormality of the preputium (HP:0100587)1.58257240

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.98609385
2VRK25.11582198
3BUB14.56714248
4PBK3.05018587
5BCKDK3.02211894
6STK162.62134628
7SRPK12.42777852
8NME12.24008665
9PIM22.22183419
10TESK22.11770806
11CDC72.10153195
12NEK12.05957931
13VRK11.93259562
14ARAF1.84641382
15IRAK31.81698943
16EIF2AK11.80575378
17ZAK1.71037278
18TESK11.71013501
19KDR1.63897386
20PDK21.61247484
21ABL21.49501115
22PLK41.33403788
23AURKA1.31336022
24TSSK61.28130371
25SMG11.25743723
26SCYL21.24995227
27CSNK1G31.22691930
28TAF11.22363645
29EIF2AK31.20200870
30PLK11.12856211
31ILK1.12355914
32TLK11.11149471
33TRIM281.10348086
34TTK1.08928258
35CHEK21.07816449
36AURKB1.06292985
37TAOK21.05318992
38CDK81.03503375
39WEE11.02956135
40RPS6KA51.00860762
41BRSK11.00845457
42BRAF0.99438671
43DAPK30.98037462
44DAPK10.95327802
45EPHA20.93142737
46MAP4K20.92714955
47PLK30.89858467
48LRRK20.88287539
49CSNK1A1L0.85540329
50CSNK1G10.84648315
51CDK70.84434341
52NUAK10.84153485
53STK40.83017339
54MAP2K70.81578232
55LIMK10.78514065
56ATR0.78489521
57CSNK2A10.76828115
58CSNK2A20.76700649
59PINK10.75573513
60RPS6KA40.74730864
61MAP3K120.74617849
62MST40.74534095
63MARK30.72069481
64MAP3K80.71128357
65MUSK0.69677494
66PRKCI0.69560323
67CSNK1G20.69119137
68MAP3K110.68793541
69PAK10.68770761
70PAK40.66341077
71RPS6KB20.64853443
72DYRK20.64679957
73CHEK10.62700419
74DYRK30.61875788
75CAMK2G0.61113867
76AKT20.58247257
77CDK190.56360355
78IKBKB0.55080841
79IRAK20.54697349
80CCNB10.44896771
81BRSK20.42941374
82FLT30.38289453
83MAP3K50.36177169
84EIF2AK20.35950857
85MYLK0.34519030
86ATM0.33758915
87CDK40.33091879
88SIK30.32924346
89OBSCN0.32845268
90TBK10.31915737
91BMX0.30779664
92MAPKAPK50.28924410
93MAPKAPK30.28375700
94STK100.27405704
95CSNK1A10.27123995
96CDK20.26696905
97MST1R0.26117259
98MAP3K30.25295773
99CAMK2D0.25234257
100RAF10.24424531

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.91133664
2Proteasome_Homo sapiens_hsa030504.41034855
3Oxidative phosphorylation_Homo sapiens_hsa001903.63889661
4DNA replication_Homo sapiens_hsa030303.44557532
5RNA polymerase_Homo sapiens_hsa030203.30997700
6Parkinsons disease_Homo sapiens_hsa050123.23946574
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.11413538
8Mismatch repair_Homo sapiens_hsa034302.73613603
9Sulfur relay system_Homo sapiens_hsa041222.71414467
10Base excision repair_Homo sapiens_hsa034102.56124898
11Pyrimidine metabolism_Homo sapiens_hsa002402.41519123
12Huntingtons disease_Homo sapiens_hsa050162.39899736
13Spliceosome_Homo sapiens_hsa030402.28872530
14Homologous recombination_Homo sapiens_hsa034402.07475717
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.00957158
16Alzheimers disease_Homo sapiens_hsa050101.99430974
17Nucleotide excision repair_Homo sapiens_hsa034201.84655858
18RNA transport_Homo sapiens_hsa030131.75111576
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74074105
20Protein export_Homo sapiens_hsa030601.71486206
21Folate biosynthesis_Homo sapiens_hsa007901.61039810
22One carbon pool by folate_Homo sapiens_hsa006701.58228307
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53952287
24Fanconi anemia pathway_Homo sapiens_hsa034601.52410311
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37825222
26Purine metabolism_Homo sapiens_hsa002301.35725106
27RNA degradation_Homo sapiens_hsa030181.33290353
28Glutathione metabolism_Homo sapiens_hsa004801.32972607
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.27502111
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27342162
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24121212
32Basal transcription factors_Homo sapiens_hsa030221.23578952
33Cardiac muscle contraction_Homo sapiens_hsa042601.23100094
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22559134
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20540485
36Biosynthesis of amino acids_Homo sapiens_hsa012301.14970412
37Fatty acid elongation_Homo sapiens_hsa000621.12157600
38Carbon metabolism_Homo sapiens_hsa012001.05998067
39Sulfur metabolism_Homo sapiens_hsa009201.02903189
40Vitamin B6 metabolism_Homo sapiens_hsa007501.01852777
41Pyruvate metabolism_Homo sapiens_hsa006200.97867103
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97027910
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96880373
44Cell cycle_Homo sapiens_hsa041100.96073493
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92347530
46Non-homologous end-joining_Homo sapiens_hsa034500.91097430
47Pentose phosphate pathway_Homo sapiens_hsa000300.90393728
48Metabolic pathways_Homo sapiens_hsa011000.87323603
49N-Glycan biosynthesis_Homo sapiens_hsa005100.86935591
50Fructose and mannose metabolism_Homo sapiens_hsa000510.81855990
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80605710
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.73275960
53mRNA surveillance pathway_Homo sapiens_hsa030150.70267090
54Peroxisome_Homo sapiens_hsa041460.69542425
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68265631
56Galactose metabolism_Homo sapiens_hsa000520.65735898
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.63686228
58Selenocompound metabolism_Homo sapiens_hsa004500.60547280
59p53 signaling pathway_Homo sapiens_hsa041150.58931450
60Arginine and proline metabolism_Homo sapiens_hsa003300.57658179
61Tyrosine metabolism_Homo sapiens_hsa003500.53904041
62Epstein-Barr virus infection_Homo sapiens_hsa051690.53107892
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52149165
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49899619
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49707456
66Phenylalanine metabolism_Homo sapiens_hsa003600.49311017
67Propanoate metabolism_Homo sapiens_hsa006400.47918193
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47853615
69Systemic lupus erythematosus_Homo sapiens_hsa053220.46100774
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45652126
71Regulation of autophagy_Homo sapiens_hsa041400.41644323
72Collecting duct acid secretion_Homo sapiens_hsa049660.39317839
73Steroid biosynthesis_Homo sapiens_hsa001000.38744424
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38339412
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36047439
76Vibrio cholerae infection_Homo sapiens_hsa051100.33777166
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33591594
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31908779
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28946921
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27679775
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.22076269
82Butanoate metabolism_Homo sapiens_hsa006500.20841030
83Oocyte meiosis_Homo sapiens_hsa041140.19219703
84Primary immunodeficiency_Homo sapiens_hsa053400.15985109
85Chemical carcinogenesis_Homo sapiens_hsa052040.15972822
86Arginine biosynthesis_Homo sapiens_hsa002200.14029851
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.11923252
88Shigellosis_Homo sapiens_hsa051310.11835559
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10979307
90Fatty acid metabolism_Homo sapiens_hsa012120.08919506
91Vitamin digestion and absorption_Homo sapiens_hsa049770.08907681
92beta-Alanine metabolism_Homo sapiens_hsa004100.07932290
93Alcoholism_Homo sapiens_hsa050340.07256703
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.07249620
95Bladder cancer_Homo sapiens_hsa052190.06611200
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.06599560
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.05131714
98Arachidonic acid metabolism_Homo sapiens_hsa005900.05120275
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.04739981
100Viral carcinogenesis_Homo sapiens_hsa052030.04538015

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