ZNF598

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)4.61346854
2regulation of mammary gland epithelial cell proliferation (GO:0033599)4.37547256
3negative regulation of erythrocyte differentiation (GO:0045647)4.33872885
4apoptotic process involved in morphogenesis (GO:0060561)3.92497019
5proline biosynthetic process (GO:0006561)3.72687227
6regulation of translational fidelity (GO:0006450)3.69799070
7mitotic chromosome condensation (GO:0007076)3.69042357
8DNA unwinding involved in DNA replication (GO:0006268)3.65072639
9negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.55740413
10heterochromatin organization (GO:0070828)3.54527759
11protein localization to endosome (GO:0036010)3.49121695
12activation of Rac GTPase activity (GO:0032863)3.39277407
13adherens junction assembly (GO:0034333)3.38551280
143-UTR-mediated mRNA stabilization (GO:0070935)3.36656858
15focal adhesion assembly (GO:0048041)3.35061949
16cell-substrate adherens junction assembly (GO:0007045)3.35061949
17spliceosomal tri-snRNP complex assembly (GO:0000244)3.32447029
18negative regulation of cell size (GO:0045792)3.28106439
19COPI coating of Golgi vesicle (GO:0048205)3.26865511
20Golgi transport vesicle coating (GO:0048200)3.26865511
21regulation of early endosome to late endosome transport (GO:2000641)3.22154484
22planar cell polarity pathway involved in neural tube closure (GO:0090179)3.22027898
23regulation of chromatin binding (GO:0035561)3.20514599
24mannose metabolic process (GO:0006013)3.16101224
25formation of translation preinitiation complex (GO:0001731)3.14600202
26viral transcription (GO:0019083)3.10158799
27peptidyl-arginine omega-N-methylation (GO:0035247)3.10004312
28regulation of translational termination (GO:0006449)3.03260494
29maternal placenta development (GO:0001893)3.01737111
30cell-substrate junction assembly (GO:0007044)3.00174715
31regulation of histone H3-K27 methylation (GO:0061085)2.99559380
32activation of MAPKKK activity (GO:0000185)2.99246379
33regulation of NFAT protein import into nucleus (GO:0051532)2.99087355
34maturation of SSU-rRNA (GO:0030490)2.98949810
35intracellular estrogen receptor signaling pathway (GO:0030520)2.94963815
36regulation of glucose import in response to insulin stimulus (GO:2001273)2.92768991
37mRNA stabilization (GO:0048255)2.90183590
38RNA stabilization (GO:0043489)2.90183590
39negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.90052711
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84797007
41regulation of apoptotic process involved in morphogenesis (GO:1902337)2.82030827
42negative regulation of viral release from host cell (GO:1902187)2.81432708
43cellular protein complex localization (GO:0034629)2.80165495
44modulation by symbiont of host cellular process (GO:0044068)2.78904247
45translational termination (GO:0006415)2.78636894
46hemidesmosome assembly (GO:0031581)2.76122970
47positive regulation of keratinocyte differentiation (GO:0045618)2.75427107
48regulation of RNA export from nucleus (GO:0046831)2.71856466
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.70834563
50modulation by virus of host process (GO:0019054)2.70705767
51positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.68806847
52NIK/NF-kappaB signaling (GO:0038061)2.68216174
53negative regulation of mRNA processing (GO:0050686)2.67224625
54pentose-phosphate shunt (GO:0006098)2.65326473
55retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.62969430
56pinocytosis (GO:0006907)2.62806935
57negative regulation of mRNA metabolic process (GO:1903312)2.62758162
58maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.61655264
59positive regulation of Cdc42 GTPase activity (GO:0043089)2.60934415
60protein retention in ER lumen (GO:0006621)2.59969136
61protein complex localization (GO:0031503)2.59545412
62positive regulation of histone deacetylation (GO:0031065)2.59517116
63embryonic process involved in female pregnancy (GO:0060136)2.58767608
64nuclear pore complex assembly (GO:0051292)2.58254644
65rRNA transcription (GO:0009303)2.56784838
66activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.56640426
67regulation of nucleobase-containing compound transport (GO:0032239)2.54660760
68positive regulation of nuclease activity (GO:0032075)2.54029461
69ribonucleoprotein complex biogenesis (GO:0022613)2.51673195
70apoptotic process involved in development (GO:1902742)2.51301260
71DNA replication initiation (GO:0006270)2.51188156
72desmosome organization (GO:0002934)2.50948321
73epithelial cell differentiation involved in prostate gland development (GO:0060742)2.50104521
74translational elongation (GO:0006414)2.49089038
75proline metabolic process (GO:0006560)2.48354033
76negative regulation of fatty acid transport (GO:2000192)2.48102774
77negative regulation of RNA splicing (GO:0033119)2.47886133
78intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.47097476
79positive regulation of blood vessel endothelial cell migration (GO:0043536)2.46677150
80folic acid metabolic process (GO:0046655)2.44921430
81mitotic G1 DNA damage checkpoint (GO:0031571)2.44621791
82basement membrane organization (GO:0071711)2.44136486
83atrioventricular valve morphogenesis (GO:0003181)2.41364882
84positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.40971533
85peptidyl-arginine methylation (GO:0018216)2.40760847
86peptidyl-arginine N-methylation (GO:0035246)2.40760847
87semaphorin-plexin signaling pathway (GO:0071526)2.40410197
88histone arginine methylation (GO:0034969)2.39957844
89viral life cycle (GO:0019058)2.39949513
90nucleosome disassembly (GO:0006337)2.39586882
91protein-DNA complex disassembly (GO:0032986)2.39586882
92glucose catabolic process (GO:0006007)2.39328057
93mitotic G1/S transition checkpoint (GO:0044819)2.38799122
94trophectodermal cell differentiation (GO:0001829)2.38637865
95vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.37337326
96positive regulation of DNA-dependent DNA replication (GO:2000105)2.35943160
97response to laminar fluid shear stress (GO:0034616)2.35381877
98nucleobase-containing small molecule interconversion (GO:0015949)2.34660139
99response to peptidoglycan (GO:0032494)2.32730480
100nuclear envelope reassembly (GO:0031468)2.32444179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.51211891
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.31111036
3MYC_22102868_ChIP-Seq_BL_Human3.11297610
4VDR_21846776_ChIP-Seq_THP-1_Human2.98694761
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54908424
6LXR_22292898_ChIP-Seq_THP-1_Human2.47129807
7* ELK3_25401928_ChIP-Seq_HUVEC_Human2.38637462
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.32439827
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29996100
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.28199750
11ZNF263_19887448_ChIP-Seq_K562_Human2.18255793
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15107286
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14740831
14* RACK7_27058665_Chip-Seq_MCF-7_Human2.10286548
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.09226615
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.09053846
17EGR1_19374776_ChIP-ChIP_THP-1_Human1.98684953
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95547370
19KDM2B_26808549_Chip-Seq_DND41_Human1.90539051
20FOXM1_23109430_ChIP-Seq_U2OS_Human1.90360077
21TCF7_22412390_ChIP-Seq_EML_Mouse1.87477691
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86604588
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85441967
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82446535
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80059831
26XRN2_22483619_ChIP-Seq_HELA_Human1.62251707
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61752368
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59107967
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58357894
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57242797
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57160883
32CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54992837
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.53470127
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50359685
35KDM2B_26808549_Chip-Seq_K562_Human1.50007894
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49467406
37P68_20966046_ChIP-Seq_HELA_Human1.48192998
38VDR_24763502_ChIP-Seq_THP-1_Human1.47949618
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47741536
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45081953
41* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38589668
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38250259
43KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38131507
44* SA1_27219007_Chip-Seq_ERYTHROID_Human1.37523356
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37300731
46MAF_26560356_Chip-Seq_TH1_Human1.37269938
47CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.37217398
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36592933
49MAF_26560356_Chip-Seq_TH2_Human1.36321271
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36124152
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35140020
52ATF3_27146783_Chip-Seq_COLON_Human1.33534437
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31344329
54NCOR1_26117541_ChIP-Seq_K562_Human1.31305438
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.29565985
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27659364
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26790792
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24648849
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24592479
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24123328
61* CREB1_26743006_Chip-Seq_LNCaP_Human1.23455897
62EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22009973
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21198467
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.20112953
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18401254
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.17578286
67UTX_26944678_Chip-Seq_JUKART_Human1.17568187
68TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17394798
69SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16090974
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16061631
71SMC4_20622854_ChIP-Seq_HELA_Human1.15640043
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12640797
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12507004
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12300420
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.10508190
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09103047
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08221205
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07871722
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07775683
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.07265378
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07232189
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07174468
83TP53_22127205_ChIP-Seq_IMR90_Human1.07032866
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06572733
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05334714
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03482464
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01763501
88CLOCK_20551151_ChIP-Seq_293T_Human1.01312595
89UBF1/2_26484160_Chip-Seq_HMECs_Human1.01235019
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00181953
91BCOR_27268052_Chip-Seq_Bcells_Human1.00067917
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99621922
93KDM5A_27292631_Chip-Seq_BREAST_Human0.98938369
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98609059
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97923546
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97706401
97RUNX1_27514584_Chip-Seq_MCF-7_Human0.97257199
98DCP1A_22483619_ChIP-Seq_HELA_Human0.96885089
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95391165
100JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95182148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.44264124
2MP0005451_abnormal_body_composition3.19780737
3MP0005076_abnormal_cell_differentiation2.96038956
4MP0002877_abnormal_melanocyte_morpholog2.78728181
5MP0004185_abnormal_adipocyte_glucose2.44554694
6MP0000678_abnormal_parathyroid_gland2.39774350
7MP0010234_abnormal_vibrissa_follicle2.35984285
8MP0005058_abnormal_lysosome_morphology2.30200880
9MP0002796_impaired_skin_barrier2.24768658
10MP0003453_abnormal_keratinocyte_physiol2.19270630
11MP0001849_ear_inflammation2.18052166
12MP0003111_abnormal_nucleus_morphology2.12107089
13MP0004858_abnormal_nervous_system2.07869264
14MP0002249_abnormal_larynx_morphology1.99750535
15MP0003566_abnormal_cell_adhesion1.96950723
16MP0003693_abnormal_embryo_hatching1.94701795
17MP0005501_abnormal_skin_physiology1.87433111
18MP0009278_abnormal_bone_marrow1.86324954
19MP0003303_peritoneal_inflammation1.79278751
20MP0008260_abnormal_autophagy1.78366756
21MP0009333_abnormal_splenocyte_physiolog1.68741649
22MP0002396_abnormal_hematopoietic_system1.64339991
23MP0000733_abnormal_muscle_development1.55164966
24MP0001730_embryonic_growth_arrest1.54934311
25MP0005666_abnormal_adipose_tissue1.52473613
26MP0005623_abnormal_meninges_morphology1.51259737
27MP0000350_abnormal_cell_proliferation1.50791742
28MP0000858_altered_metastatic_potential1.49470035
29MP0009840_abnormal_foam_cell1.48925675
30MP0003077_abnormal_cell_cycle1.48653986
31MP0008438_abnormal_cutaneous_collagen1.47876514
32MP0002060_abnormal_skin_morphology1.47301940
33MP0004947_skin_inflammation1.46216720
34MP0000537_abnormal_urethra_morphology1.45926319
35MP0001873_stomach_inflammation1.44665404
36MP0004808_abnormal_hematopoietic_stem1.44001237
37MP0004233_abnormal_muscle_weight1.43577283
38MP0003436_decreased_susceptibility_to1.42173830
39MP0004957_abnormal_blastocyst_morpholog1.38201584
40MP0004381_abnormal_hair_follicle1.36930948
41MP0005375_adipose_tissue_phenotype1.34922643
42MP0001348_abnormal_lacrimal_gland1.34510924
43MP0010094_abnormal_chromosome_stability1.31357875
44MP0004510_myositis1.31301865
45MP0000490_abnormal_crypts_of1.29808576
46MP0003091_abnormal_cell_migration1.28881983
47MP0010352_gastrointestinal_tract_polyps1.28502271
48MP0000003_abnormal_adipose_tissue1.28123423
49MP0005409_darkened_coat_color1.25988776
50MP0003763_abnormal_thymus_physiology1.24927411
51MP0001216_abnormal_epidermal_layer1.19520726
52MP0009379_abnormal_foot_pigmentation1.15323333
53MP0002089_abnormal_postnatal_growth/wei1.09498650
54MP0005621_abnormal_cell_physiology1.08031332
55MP0003300_gastrointestinal_ulcer1.07956493
56MP0009931_abnormal_skin_appearance1.06122836
57MP0002080_prenatal_lethality1.04574677
58MP0008932_abnormal_embryonic_tissue1.04060408
59MP0010030_abnormal_orbit_morphology1.03568940
60MP0003172_abnormal_lysosome_physiology1.03302179
61MP0000467_abnormal_esophagus_morphology1.02357331
62MP0000313_abnormal_cell_death1.02116979
63MP0002098_abnormal_vibrissa_morphology1.00987805
64MP0009672_abnormal_birth_weight0.98959407
65MP0000579_abnormal_nail_morphology0.98430245
66MP0005023_abnormal_wound_healing0.98406233
67MP0003191_abnormal_cellular_cholesterol0.95576457
68MP0010307_abnormal_tumor_latency0.94912571
69MP0005380_embryogenesis_phenotype0.94027912
70MP0001672_abnormal_embryogenesis/_devel0.94027912
71MP0000703_abnormal_thymus_morphology0.93364282
72MP0002086_abnormal_extraembryonic_tissu0.91513164
73MP0003984_embryonic_growth_retardation0.90527016
74MP0001346_abnormal_lacrimal_gland0.88763667
75MP0004272_abnormal_basement_membrane0.86673093
76MP0005257_abnormal_intraocular_pressure0.86637961
77MP0009053_abnormal_anal_canal0.86147508
78MP0000759_abnormal_skeletal_muscle0.83729902
79MP0000762_abnormal_tongue_morphology0.82882776
80MP0002088_abnormal_embryonic_growth/wei0.82821124
81MP0004264_abnormal_extraembryonic_tissu0.82395700
82MP0008007_abnormal_cellular_replicative0.82311076
83MP0001697_abnormal_embryo_size0.80889911
84MP0004782_abnormal_surfactant_physiolog0.80231189
85MP0002085_abnormal_embryonic_tissue0.78135041
86MP0000681_abnormal_thyroid_gland0.77305492
87MP0010771_integument_phenotype0.75295168
88MP0010630_abnormal_cardiac_muscle0.74564698
89MP0005384_cellular_phenotype0.74410078
90MP0003123_paternal_imprinting0.73766827
91MP0005397_hematopoietic_system_phenotyp0.73057644
92MP0001545_abnormal_hematopoietic_system0.73057644
93MP0002398_abnormal_bone_marrow0.72925618
94MP0004197_abnormal_fetal_growth/weight/0.72921358
95MP0001853_heart_inflammation0.72915188
96MP0003279_aneurysm0.72165941
97MP0003942_abnormal_urinary_system0.70771105
98MP0000767_abnormal_smooth_muscle0.69548759
99MP0000685_abnormal_immune_system0.68322231
100MP0003115_abnormal_respiratory_system0.67964023

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.64839787
2Ulnar bowing (HP:0003031)3.05304254
3Broad face (HP:0000283)2.96773155
4Distal lower limb amyotrophy (HP:0008944)2.92319026
5Achilles tendon contracture (HP:0001771)2.87479556
6Protrusio acetabuli (HP:0003179)2.68578742
7Disproportionate tall stature (HP:0001519)2.59821552
8Trismus (HP:0000211)2.59422035
9Obstructive sleep apnea (HP:0002870)2.58230704
10Thin bony cortex (HP:0002753)2.53585168
11Premature rupture of membranes (HP:0001788)2.49192102
12Abnormality of the Achilles tendon (HP:0005109)2.48755154
13Selective tooth agenesis (HP:0001592)2.42465935
14Increased connective tissue (HP:0009025)2.41094148
15Long palpebral fissure (HP:0000637)2.38898113
16Progressive muscle weakness (HP:0003323)2.38882963
17Vertebral compression fractures (HP:0002953)2.38450196
18Premature skin wrinkling (HP:0100678)2.38020679
19Abnormality of the thoracic spine (HP:0100711)2.32448280
20Fragile skin (HP:0001030)2.29270866
21Septate vagina (HP:0001153)2.25426216
22Upper limb amyotrophy (HP:0009129)2.25039514
23Distal upper limb amyotrophy (HP:0007149)2.25039514
24Broad distal phalanx of finger (HP:0009836)2.19679096
25Cerebral aneurysm (HP:0004944)2.19087782
26Abnormality of the distal phalanges of the toes (HP:0010182)2.17349053
27Stridor (HP:0010307)2.14456070
28Flat acetabular roof (HP:0003180)2.07559303
29Sparse lateral eyebrow (HP:0005338)2.05505821
30Syringomyelia (HP:0003396)2.05367693
31Spinal cord lesions (HP:0100561)2.05367693
32Truncus arteriosus (HP:0001660)2.04083724
33J-shaped sella turcica (HP:0002680)2.03344576
34Insomnia (HP:0100785)2.02423066
35Thoracic kyphosis (HP:0002942)2.00938724
36Shallow orbits (HP:0000586)2.00576155
37Hyperparathyroidism (HP:0000843)1.98179212
38Genu recurvatum (HP:0002816)1.97624400
39Distal lower limb muscle weakness (HP:0009053)1.97418554
40Hypertensive crisis (HP:0100735)1.96998648
41Abnormality of the distal phalanx of the thumb (HP:0009617)1.96041550
42Elbow flexion contracture (HP:0002987)1.94653324
43Biconcave vertebral bodies (HP:0004586)1.94258562
44Patellar dislocation (HP:0002999)1.93011548
45Dysmetric saccades (HP:0000641)1.92903901
46Centrally nucleated skeletal muscle fibers (HP:0003687)1.92880315
47Mitral regurgitation (HP:0001653)1.90434952
48Asymmetry of the thorax (HP:0001555)1.88729596
49Abnormality of the umbilical cord (HP:0010881)1.88066801
50Ragged-red muscle fibers (HP:0003200)1.86495286
51Generalized amyotrophy (HP:0003700)1.83878923
52Abnormality of the fingertips (HP:0001211)1.82716930
53Abnormality of the phalanges of the hallux (HP:0010057)1.82703421
54Spinal rigidity (HP:0003306)1.80982748
55Reticulocytosis (HP:0001923)1.80956373
56Cellulitis (HP:0100658)1.79556571
57Deep palmar crease (HP:0006191)1.78590568
58Lower limb amyotrophy (HP:0007210)1.77966557
59Ankyloglossia (HP:0010296)1.77591673
60Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76909486
61Short nail (HP:0001799)1.76854552
62Mildly elevated creatine phosphokinase (HP:0008180)1.75054877
63Urethral obstruction (HP:0000796)1.72580105
64Easy fatigability (HP:0003388)1.72492761
65Atrophic scars (HP:0001075)1.72152735
66Seborrheic dermatitis (HP:0001051)1.71650119
67Spinal cord compression (HP:0002176)1.70087209
68Blue sclerae (HP:0000592)1.69910389
69Breast hypoplasia (HP:0003187)1.69870853
70Myopathic facies (HP:0002058)1.69617893
71Bowing of the arm (HP:0006488)1.69500055
72Bowed forearm bones (HP:0003956)1.69500055
73Squamous cell carcinoma (HP:0002860)1.68418377
74Long eyelashes (HP:0000527)1.68073491
75Cervical subluxation (HP:0003308)1.68009821
76Abnormality of nail color (HP:0100643)1.67780461
77Hyperthyroidism (HP:0000836)1.67458284
78Increased variability in muscle fiber diameter (HP:0003557)1.67376504
79Polygenic inheritance (HP:0010982)1.65620570
80Nonimmune hydrops fetalis (HP:0001790)1.65332520
81Difficulty climbing stairs (HP:0003551)1.65047940
82Nasolacrimal duct obstruction (HP:0000579)1.64356482
83Bowel incontinence (HP:0002607)1.64271951
84Deviation of the thumb (HP:0009603)1.63756656
85Abnormal gallbladder physiology (HP:0012438)1.63646314
86Cholecystitis (HP:0001082)1.63646314
87Abnormal umbilical cord blood vessels (HP:0011403)1.63599370
88Single umbilical artery (HP:0001195)1.63599370
89Abnormality of the fetal cardiovascular system (HP:0010948)1.63599370
90Advanced eruption of teeth (HP:0006288)1.61611315
91Abnormality of the salivary glands (HP:0010286)1.61606227
92Natal tooth (HP:0000695)1.60771795
93Abnormality of reticulocytes (HP:0004312)1.60491976
94Segmental peripheral demyelination/remyelination (HP:0003481)1.60402213
95Emphysema (HP:0002097)1.60134716
96Abnormal large intestine physiology (HP:0012700)1.59557380
97Multiple enchondromatosis (HP:0005701)1.59147924
98Axonal loss (HP:0003447)1.59040024
99Dislocated radial head (HP:0003083)1.58773086
100Self-mutilation (HP:0000742)1.58540801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.09091436
2SMG13.83825530
3IRAK33.60900691
4NME23.48875706
5EEF2K3.31103266
6SIK13.29757257
7PRPF4B3.23806515
8CDK122.67433604
9ICK2.66662031
10ERN12.59794484
11MAP3K102.32093095
12MAP3K131.96175279
13EPHA21.85345358
14TAOK21.69257862
15MAP2K31.68120948
16PKN21.57826909
17MST1R1.30436017
18TTN1.26820010
19PAK41.26254049
20MTOR1.22195599
21TAOK11.20397510
22ARAF1.16812440
23PRKD31.15583841
24IRAK21.13926321
25IRAK41.13301782
26FGFR41.09950098
27MAP3K111.08582505
28MAP3K141.08575238
29RIPK11.06385691
30RPS6KB21.06165835
31PDGFRA1.02903606
32MAP3K31.01724537
33CDK41.01357222
34PTK60.98939352
35PRKD20.97697821
36MAP4K10.96493799
37CDK70.96134433
38MAP3K80.95367048
39SIK20.89486575
40MARK20.89230385
41PIM20.87628842
42SIK30.86595892
43MAP3K10.85268677
44PTK20.84706649
45KSR20.80877771
46BRAF0.78934223
47MAPK110.77152765
48PDPK10.77043616
49RPS6KL10.75696097
50RPS6KC10.75696097
51CDC42BPA0.74974450
52ILK0.72921864
53LATS20.71459299
54LRRK20.70897757
55RPS6KA20.70546376
56TBK10.67397117
57HIPK20.66727850
58TESK10.66625165
59MAP2K20.66541989
60BUB10.65083588
61LMTK20.64238485
62BMX0.62857548
63CDC70.58739482
64SCYL20.57819601
65RIPK40.54138625
66RPS6KA60.53470229
67CHEK20.53463240
68MET0.52893819
69AURKA0.52760380
70CDK80.52689982
71CHEK10.52231219
72MAP3K90.52227527
73CHUK0.50373701
74TESK20.49210884
75EPHB10.48210895
76KDR0.46792351
77MOS0.45270109
78CAMK1D0.44982373
79CDK60.44732991
80RPS6KA10.44331547
81DDR20.42338992
82CDK90.42137864
83PRKCI0.38321160
84TYRO30.37611944
85AKT20.37242589
86MAP3K70.37093216
87IKBKB0.37073261
88CDK20.35489032
89ABL20.35130685
90PAK20.34477267
91DMPK0.33824089
92MAPKAPK20.33767680
93BRD40.33418686
94CLK10.33085590
95STK40.33037023
96MAP3K60.32951854
97PDK10.32940246
98GRK60.32257049
99ZAP700.31557279
100NTRK10.30654044

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052202.40839267
2Acute myeloid leukemia_Homo sapiens_hsa052212.27006201
3Bladder cancer_Homo sapiens_hsa052192.23940921
4Other glycan degradation_Homo sapiens_hsa005112.22856522
5DNA replication_Homo sapiens_hsa030302.17207511
6Notch signaling pathway_Homo sapiens_hsa043302.07336913
7Sulfur relay system_Homo sapiens_hsa041222.03693593
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.03238967
9Non-small cell lung cancer_Homo sapiens_hsa052231.89451503
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87181924
11Central carbon metabolism in cancer_Homo sapiens_hsa052301.75932806
12Ribosome_Homo sapiens_hsa030101.74835828
13Pancreatic cancer_Homo sapiens_hsa052121.68333661
14VEGF signaling pathway_Homo sapiens_hsa043701.66544433
15B cell receptor signaling pathway_Homo sapiens_hsa046621.52566439
16Pentose phosphate pathway_Homo sapiens_hsa000301.47634356
17Base excision repair_Homo sapiens_hsa034101.47393784
18Thyroid cancer_Homo sapiens_hsa052161.47379501
19Spliceosome_Homo sapiens_hsa030401.44077810
20Small cell lung cancer_Homo sapiens_hsa052221.39087697
21Prion diseases_Homo sapiens_hsa050201.37018378
22Fructose and mannose metabolism_Homo sapiens_hsa000511.36984428
23mTOR signaling pathway_Homo sapiens_hsa041501.32565672
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.32340454
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28426846
26Biosynthesis of amino acids_Homo sapiens_hsa012301.26778085
27Endometrial cancer_Homo sapiens_hsa052131.26227235
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.25092350
29Renal cell carcinoma_Homo sapiens_hsa052111.23147355
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20878767
31Glioma_Homo sapiens_hsa052141.20798877
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18804349
33MicroRNAs in cancer_Homo sapiens_hsa052061.17547385
34Cell cycle_Homo sapiens_hsa041101.15550545
35Hepatitis B_Homo sapiens_hsa051611.15216177
36ErbB signaling pathway_Homo sapiens_hsa040121.14477089
37HTLV-I infection_Homo sapiens_hsa051661.13586637
38Apoptosis_Homo sapiens_hsa042101.12612619
39Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12343358
40Insulin signaling pathway_Homo sapiens_hsa049101.11900436
41Galactose metabolism_Homo sapiens_hsa000521.09812989
42Prostate cancer_Homo sapiens_hsa052151.07953524
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04933402
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04827626
45mRNA surveillance pathway_Homo sapiens_hsa030151.03151784
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02145077
47TNF signaling pathway_Homo sapiens_hsa046681.01378222
48Viral carcinogenesis_Homo sapiens_hsa052031.00397747
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99966396
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97179518
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.94237363
52Hepatitis C_Homo sapiens_hsa051600.93833786
53Osteoclast differentiation_Homo sapiens_hsa043800.93759562
54Influenza A_Homo sapiens_hsa051640.92622701
55Epstein-Barr virus infection_Homo sapiens_hsa051690.91486574
56Shigellosis_Homo sapiens_hsa051310.89635864
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88671238
58Herpes simplex infection_Homo sapiens_hsa051680.88489736
59AMPK signaling pathway_Homo sapiens_hsa041520.87747955
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.87284128
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84365690
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83267541
63Proteoglycans in cancer_Homo sapiens_hsa052050.83144214
64Colorectal cancer_Homo sapiens_hsa052100.83143435
65Toxoplasmosis_Homo sapiens_hsa051450.82466406
66RNA transport_Homo sapiens_hsa030130.82162950
67Lysine degradation_Homo sapiens_hsa003100.81486459
68Pyrimidine metabolism_Homo sapiens_hsa002400.79483165
69Focal adhesion_Homo sapiens_hsa045100.79197788
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78866668
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.78817844
72Prolactin signaling pathway_Homo sapiens_hsa049170.78425367
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78192147
74T cell receptor signaling pathway_Homo sapiens_hsa046600.75075891
75Insulin resistance_Homo sapiens_hsa049310.73105381
76GnRH signaling pathway_Homo sapiens_hsa049120.72120019
77Vitamin B6 metabolism_Homo sapiens_hsa007500.70924159
78Choline metabolism in cancer_Homo sapiens_hsa052310.70608306
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69946613
80HIF-1 signaling pathway_Homo sapiens_hsa040660.69063427
81Measles_Homo sapiens_hsa051620.67124331
82Melanoma_Homo sapiens_hsa052180.67086114
83One carbon pool by folate_Homo sapiens_hsa006700.65365138
84Amoebiasis_Homo sapiens_hsa051460.65153947
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.64920500
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64516927
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62172464
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61554649
89Leishmaniasis_Homo sapiens_hsa051400.61144046
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.60571059
91Estrogen signaling pathway_Homo sapiens_hsa049150.59790212
92p53 signaling pathway_Homo sapiens_hsa041150.59723522
93N-Glycan biosynthesis_Homo sapiens_hsa005100.55744669
94Salmonella infection_Homo sapiens_hsa051320.53871525
95Pathways in cancer_Homo sapiens_hsa052000.53321411
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52691197
97Inositol phosphate metabolism_Homo sapiens_hsa005620.52138633
98Nucleotide excision repair_Homo sapiens_hsa034200.50798140
99Endocytosis_Homo sapiens_hsa041440.50181421
100Carbon metabolism_Homo sapiens_hsa012000.49749092

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