ZNF600

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)5.05269606
2negative regulation of cell killing (GO:0031342)4.98349664
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.98349664
4cellular response to interleukin-15 (GO:0071350)4.28248059
5DNA deamination (GO:0045006)4.07853765
6positive regulation of gamma-delta T cell activation (GO:0046645)3.92621448
7response to interleukin-15 (GO:0070672)3.92142932
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.86105853
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.84566692
10cytidine metabolic process (GO:0046087)3.78356579
11cytidine catabolic process (GO:0006216)3.78356579
12cytidine deamination (GO:0009972)3.78356579
13pyrimidine ribonucleoside catabolic process (GO:0046133)3.71405997
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.69320933
15regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.54888795
16regulation of activation of Janus kinase activity (GO:0010533)3.53194474
17regulation of gamma-delta T cell differentiation (GO:0045586)3.51930598
18regulation of T cell receptor signaling pathway (GO:0050856)3.45800508
19antigen processing and presentation of endogenous antigen (GO:0019883)3.45718596
20regulation of interferon-beta biosynthetic process (GO:0045357)3.41127536
21negative regulation of B cell proliferation (GO:0030889)3.36497850
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.35391575
23negative regulation of mast cell activation (GO:0033004)3.33352347
24negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.31840155
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.31780142
26tolerance induction (GO:0002507)3.31660663
27interferon-gamma production (GO:0032609)3.31511270
28regulation of gamma-delta T cell activation (GO:0046643)3.30346580
29rRNA catabolic process (GO:0016075)3.27072199
30negative T cell selection (GO:0043383)3.25996312
31negative thymic T cell selection (GO:0045060)3.11458177
32positive regulation of defense response to virus by host (GO:0002230)3.11177410
33mast cell activation (GO:0045576)3.07488557
34regulation of B cell differentiation (GO:0045577)3.05673444
35positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.01106037
36regulation of leukocyte mediated cytotoxicity (GO:0001910)2.99367452
37positive regulation of natural killer cell differentiation (GO:0032825)2.96893063
38adenosine metabolic process (GO:0046085)2.96385014
39positive regulation of T cell mediated cytotoxicity (GO:0001916)2.96300957
40regulation of alpha-beta T cell proliferation (GO:0046640)2.95183185
41positive regulation of B cell differentiation (GO:0045579)2.94948189
42regulation of T cell mediated cytotoxicity (GO:0001914)2.93901487
43regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.92882467
44regulation of natural killer cell mediated immunity (GO:0002715)2.92882467
45organelle membrane fusion (GO:0090174)2.92114580
46mast cell degranulation (GO:0043303)2.92110902
47mast cell activation involved in immune response (GO:0002279)2.92110902
48neutrophil activation (GO:0042119)2.91768617
49granulocyte activation (GO:0036230)2.89820627
50regulation of cytokine secretion involved in immune response (GO:0002739)2.86138916
51regulation of regulatory T cell differentiation (GO:0045589)2.86080933
52hepatocyte apoptotic process (GO:0097284)2.85667368
53interferon-gamma secretion (GO:0072643)2.84677217
54rRNA methylation (GO:0031167)2.84175270
55negative regulation of alpha-beta T cell activation (GO:0046636)2.84146647
56leukocyte degranulation (GO:0043299)2.82498408
57regulation of cell killing (GO:0031341)2.80636964
58positive regulation of cell killing (GO:0031343)2.79317623
59positive regulation of granulocyte differentiation (GO:0030854)2.77433086
60autophagic vacuole fusion (GO:0000046)2.75292452
61protein K11-linked deubiquitination (GO:0035871)2.73060262
62positive regulation of prostaglandin secretion (GO:0032308)2.70406082
63negative regulation of T cell mediated immunity (GO:0002710)2.70374930
64negative regulation of lymphocyte mediated immunity (GO:0002707)2.70249651
65negative regulation of leukocyte mediated immunity (GO:0002704)2.69697724
66mitochondrial DNA replication (GO:0006264)2.69552825
67L-fucose catabolic process (GO:0042355)2.66674078
68fucose catabolic process (GO:0019317)2.66674078
69L-fucose metabolic process (GO:0042354)2.66674078
70positive regulation of alpha-beta T cell proliferation (GO:0046641)2.64795654
71platelet dense granule organization (GO:0060155)2.64623207
72regulation of defense response to virus by host (GO:0050691)2.63192439
73rRNA modification (GO:0000154)2.62096565
74response to interferon-beta (GO:0035456)2.61831632
75RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61546133
76T cell migration (GO:0072678)2.61235594
77regulation of memory T cell differentiation (GO:0043380)2.60341348
78neutrophil activation involved in immune response (GO:0002283)2.59767329
79negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.55647631
80positive regulation of natural killer cell mediated immunity (GO:0002717)2.55144092
81preassembly of GPI anchor in ER membrane (GO:0016254)2.54008247
82negative regulation of B cell activation (GO:0050869)2.53466258
83B cell receptor signaling pathway (GO:0050853)2.49078851
84myeloid cell activation involved in immune response (GO:0002275)2.48867106
85negative regulation of phagocytosis (GO:0050765)2.48471938
86antigen processing and presentation via MHC class Ib (GO:0002475)2.48401538
87negative regulation of T cell apoptotic process (GO:0070233)2.47998128
88positive regulation of interferon-beta production (GO:0032728)2.46431814
89histone mRNA catabolic process (GO:0071044)2.44075191
90regulation of meiosis I (GO:0060631)2.43711613
91negative regulation of type I interferon production (GO:0032480)2.43222307
92thrombin receptor signaling pathway (GO:0070493)2.42786863
93regulation of interferon-alpha production (GO:0032647)2.42593635
94regulation of mast cell activation (GO:0033003)2.42298401
95piRNA metabolic process (GO:0034587)2.40834614
96regulation of thymocyte apoptotic process (GO:0070243)2.39916851
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.39655282
98negative regulation of T-helper cell differentiation (GO:0045623)2.39655282
99positive regulation of interferon-alpha production (GO:0032727)2.38731565
100positive T cell selection (GO:0043368)2.36335900

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.61361982
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.48203895
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.15989527
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.10626769
5NOTCH1_21737748_ChIP-Seq_TLL_Human3.10249924
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.01338521
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.84908774
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.43564969
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.40981635
10MYB_26560356_Chip-Seq_TH2_Human2.39968913
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.30966334
12VDR_23849224_ChIP-Seq_CD4+_Human2.28706321
13ZNF274_21170338_ChIP-Seq_K562_Hela2.24915433
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.13389305
15RUNX_20019798_ChIP-Seq_JUKART_Human2.09788257
16GATA3_26560356_Chip-Seq_TH2_Human2.02152574
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.00722147
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.98405706
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96007463
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.94254283
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90133347
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88314373
23FOXP3_21729870_ChIP-Seq_TREG_Human1.87071351
24ELK1_19687146_ChIP-ChIP_HELA_Human1.85244673
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83199935
26GATA3_27048872_Chip-Seq_THYMUS_Human1.79720075
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78187164
28MYB_26560356_Chip-Seq_TH1_Human1.77881424
29SPI1_23547873_ChIP-Seq_NB4_Human1.68162210
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67409203
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66361379
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66319233
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53113186
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.48241758
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47258195
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44555219
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39621425
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38190483
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37048207
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36558153
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36047982
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35296169
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34564990
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.34210725
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31166859
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.27751548
47VDR_22108803_ChIP-Seq_LS180_Human1.24917003
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24794918
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23940192
50TP53_22573176_ChIP-Seq_HFKS_Human1.21933747
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21658998
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20500492
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18866025
54CDX2_22108803_ChIP-Seq_LS180_Human1.18021138
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17473966
56* FOXA1_25329375_ChIP-Seq_VCAP_Human1.17419697
57* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17419697
58GATA1_22025678_ChIP-Seq_K562_Human1.13680758
59AR_20517297_ChIP-Seq_VCAP_Human1.13675613
60ER_23166858_ChIP-Seq_MCF-7_Human1.13246453
61CIITA_25753668_ChIP-Seq_RAJI_Human1.12347235
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11325858
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10833745
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10818565
65* GATA3_26560356_Chip-Seq_TH1_Human1.09653983
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09188002
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08874706
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.08148072
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.07537604
70IRF1_19129219_ChIP-ChIP_H3396_Human1.06102450
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05461017
72SCL_19346495_ChIP-Seq_HPC-7_Human1.05116616
73FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03186136
74BCAT_22108803_ChIP-Seq_LS180_Human1.01861655
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.01813151
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01687420
77IGF1R_20145208_ChIP-Seq_DFB_Human1.01436122
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01173174
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00141463
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97643980
81MAF_26560356_Chip-Seq_TH1_Human0.97376527
82SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96629014
83EZH2_27294783_Chip-Seq_NPCs_Mouse0.96328608
84HOXB7_26014856_ChIP-Seq_BT474_Human0.95837521
85MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95729262
86SMRT_27268052_Chip-Seq_Bcells_Human0.95520304
87CEBPB_22108803_ChIP-Seq_LS180_Human0.95426286
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93948877
89NANOG_19829295_ChIP-Seq_ESCs_Human0.93754041
90SOX2_19829295_ChIP-Seq_ESCs_Human0.93754041
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92756199
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.91704910
93MYC_18940864_ChIP-ChIP_HL60_Human0.91537789
94* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90998510
95RBPJ_21746931_ChIP-Seq_IB4_Human0.90405091
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90337927
97GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89964399
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89640717
99NANOG_20526341_ChIP-Seq_ESCs_Human0.88921295
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88875742

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.38046101
2MP0001835_abnormal_antigen_presentation3.05341519
3MP0003763_abnormal_thymus_physiology2.96410864
4MP0001800_abnormal_humoral_immune2.65341000
5MP0002138_abnormal_hepatobiliary_system2.49042743
6MP0009785_altered_susceptibility_to2.35722948
7MP0005000_abnormal_immune_tolerance2.29581757
8MP0002723_abnormal_immune_serum2.23250026
9MP0002148_abnormal_hypersensitivity_rea2.20895860
10MP0003436_decreased_susceptibility_to2.20084259
11MP0000685_abnormal_immune_system2.19426964
12MP0005075_abnormal_melanosome_morpholog2.18576448
13MP0005387_immune_system_phenotype2.16174811
14MP0001790_abnormal_immune_system2.16174811
15MP0002452_abnormal_antigen_presenting2.13503851
16MP0003806_abnormal_nucleotide_metabolis2.09046315
17MP0003724_increased_susceptibility_to2.04006044
18MP0002420_abnormal_adaptive_immunity2.03571804
19MP0001819_abnormal_immune_cell2.02556559
20MP0006054_spinal_hemorrhage1.96610926
21MP0006082_CNS_inflammation1.95384180
22MP0003195_calcinosis1.93242307
23MP0009333_abnormal_splenocyte_physiolog1.90034068
24MP0005025_abnormal_response_to1.86353084
25MP0001873_stomach_inflammation1.85622414
26MP0002254_reproductive_system_inflammat1.81832339
27MP0002398_abnormal_bone_marrow1.72490336
28MP0010155_abnormal_intestine_physiology1.70973134
29MP0005464_abnormal_platelet_physiology1.69871731
30MP0000689_abnormal_spleen_morphology1.66262804
31MP0002419_abnormal_innate_immunity1.66076915
32MP0002405_respiratory_system_inflammati1.64511181
33MP0000716_abnormal_immune_system1.62461949
34MP0008877_abnormal_DNA_methylation1.58330982
35MP0003718_maternal_effect1.57385714
36MP0002006_tumorigenesis1.51226248
37MP0002722_abnormal_immune_system1.51195808
38MP0000372_irregular_coat_pigmentation1.50618165
39MP0002166_altered_tumor_susceptibility1.49770981
40MP0002163_abnormal_gland_morphology1.46680765
41MP0001845_abnormal_inflammatory_respons1.45911994
42MP0008057_abnormal_DNA_replication1.43918214
43MP0003866_abnormal_defecation1.43325247
44MP0000703_abnormal_thymus_morphology1.39169530
45MP0005379_endocrine/exocrine_gland_phen1.36510227
46MP0002429_abnormal_blood_cell1.32636560
47MP0004043_abnormal_pH_regulation1.32384634
48MP0009764_decreased_sensitivity_to1.32345317
49MP0008469_abnormal_protein_level1.30823674
50MP0005085_abnormal_gallbladder_physiolo1.24398740
51MP0003252_abnormal_bile_duct1.23209249
52MP0002277_abnormal_respiratory_mucosa1.23004888
53MP0005310_abnormal_salivary_gland1.21902713
54MP0004381_abnormal_hair_follicle1.21323683
55MP0005174_abnormal_tail_pigmentation1.21276462
56MP0002139_abnormal_hepatobiliary_system1.19845209
57MP0000015_abnormal_ear_pigmentation1.18761870
58MP0002396_abnormal_hematopoietic_system1.15105867
59MP0001919_abnormal_reproductive_system1.14644977
60MP0001986_abnormal_taste_sensitivity1.12159643
61MP0000427_abnormal_hair_cycle1.12122393
62MP0001764_abnormal_homeostasis1.10228328
63MP0004019_abnormal_vitamin_homeostasis1.09405657
64MP0008875_abnormal_xenobiotic_pharmacok1.08727522
65MP0008872_abnormal_physiological_respon1.05872876
66MP0000569_abnormal_digit_pigmentation1.04144943
67MP0005360_urolithiasis1.04104548
68MP0001853_heart_inflammation1.02663795
69MP0005410_abnormal_fertilization1.01349260
70MP0003183_abnormal_peptide_metabolism1.00437343
71MP0003786_premature_aging1.00049894
72MP0004264_abnormal_extraembryonic_tissu0.99205734
73MP0010307_abnormal_tumor_latency0.97419022
74MP0003191_abnormal_cellular_cholesterol0.96525650
75MP0005389_reproductive_system_phenotype0.96303945
76MP0002132_abnormal_respiratory_system0.95897521
77MP0003011_delayed_dark_adaptation0.91958800
78MP0000465_gastrointestinal_hemorrhage0.91710724
79MP0009840_abnormal_foam_cell0.90879060
80MP0002693_abnormal_pancreas_physiology0.89823850
81MP0005084_abnormal_gallbladder_morpholo0.88376461
82MP0002019_abnormal_tumor_incidence0.86110352
83MP0003646_muscle_fatigue0.85546790
84MP0004947_skin_inflammation0.84214613
85MP0001533_abnormal_skeleton_physiology0.83121926
86MP0003186_abnormal_redox_activity0.81599690
87MP0002136_abnormal_kidney_physiology0.80830700
88MP0005332_abnormal_amino_acid0.79236210
89MP0005551_abnormal_eye_electrophysiolog0.78928419
90MP0006036_abnormal_mitochondrial_physio0.78788918
91MP0005636_abnormal_mineral_homeostasis0.77798855
92MP0008058_abnormal_DNA_repair0.77731933
93MP0005319_abnormal_enzyme/_coenzyme0.77103595
94MP0009643_abnormal_urine_homeostasis0.76989849
95MP0008873_increased_physiological_sensi0.76792061
96MP0003943_abnormal_hepatobiliary_system0.75746931
97MP0001765_abnormal_ion_homeostasis0.75272481
98MP0004147_increased_porphyrin_level0.74171593
99MP0005376_homeostasis/metabolism_phenot0.73016298
100MP0009697_abnormal_copulation0.69913326

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)3.99159795
2Abnormality of T cell number (HP:0011839)3.87063576
3T lymphocytopenia (HP:0005403)3.80434159
4Abnormal delayed hypersensitivity skin test (HP:0002963)3.65866804
5Abnormality of T cells (HP:0002843)3.59944337
6IgG deficiency (HP:0004315)3.48005671
7Elevated erythrocyte sedimentation rate (HP:0003565)3.45765696
8Abnormality of T cell physiology (HP:0011840)3.35560033
9Congenital stationary night blindness (HP:0007642)3.19986517
103-Methylglutaconic aciduria (HP:0003535)3.16388370
11Autoimmune hemolytic anemia (HP:0001890)3.09048917
12Chronic diarrhea (HP:0002028)3.06756970
13Panhypogammaglobulinemia (HP:0003139)3.05738715
14Severe visual impairment (HP:0001141)2.99518734
15Stomach cancer (HP:0012126)2.96824534
16Severe combined immunodeficiency (HP:0004430)2.96070518
17Recurrent fungal infections (HP:0002841)2.90440850
18Abnormal rod and cone electroretinograms (HP:0008323)2.89863343
19Albinism (HP:0001022)2.88806217
20Abnormality of B cell number (HP:0010975)2.81174023
21Recurrent bronchitis (HP:0002837)2.78529967
22Encephalitis (HP:0002383)2.74248611
23Recurrent cutaneous fungal infections (HP:0011370)2.74221827
24Chronic mucocutaneous candidiasis (HP:0002728)2.74221827
25Abnormality of the prostate (HP:0008775)2.64395770
26Abnormality of eosinophils (HP:0001879)2.54600396
27Pustule (HP:0200039)2.53547955
28Optic neuritis (HP:0100653)2.51169250
29Retrobulbar optic neuritis (HP:0100654)2.51169250
30Attenuation of retinal blood vessels (HP:0007843)2.51106541
31Chronic hepatic failure (HP:0100626)2.49389740
32Abnormality of the renal cortex (HP:0011035)2.42817876
33Pancreatic cysts (HP:0001737)2.40519600
34Myositis (HP:0100614)2.39162468
35Alveolar cell carcinoma (HP:0006519)2.38764928
36Recurrent bacterial skin infections (HP:0005406)2.37140755
37Hypoproteinemia (HP:0003075)2.35776065
38Thyroiditis (HP:0100646)2.33432842
39B lymphocytopenia (HP:0010976)2.29597844
40Leukocytosis (HP:0001974)2.26651912
41Combined immunodeficiency (HP:0005387)2.25718301
42Abnormality of midbrain morphology (HP:0002418)2.23986719
43Molar tooth sign on MRI (HP:0002419)2.23986719
44Eosinophilia (HP:0001880)2.23304992
45Meningitis (HP:0001287)2.22736748
46Recurrent skin infections (HP:0001581)2.19528253
47Orchitis (HP:0100796)2.18480294
48Aplasia/Hypoplasia of the fovea (HP:0008060)2.16140557
49Hypoplasia of the fovea (HP:0007750)2.16140557
50Recurrent abscess formation (HP:0002722)2.15903116
51Abnormality of macular pigmentation (HP:0008002)2.15718705
52Premature ovarian failure (HP:0008209)2.14354035
53IgM deficiency (HP:0002850)2.13607593
54Neoplasm of the tracheobronchial system (HP:0100552)2.12476779
55Vasculitis (HP:0002633)2.12119833
56Recurrent viral infections (HP:0004429)2.11537595
57Renal cortical cysts (HP:0000803)2.09882344
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07625797
59Abnormality of alanine metabolism (HP:0010916)2.07625797
60Hyperalaninemia (HP:0003348)2.07625797
61Agammaglobulinemia (HP:0004432)2.04433645
62Pulmonary infiltrates (HP:0002113)2.03964236
63Prostate neoplasm (HP:0100787)2.03465222
64Aplasia/hypoplasia of the uterus (HP:0008684)1.99663282
65Bronchitis (HP:0012387)1.97248413
66Joint swelling (HP:0001386)1.95877164
67Neutropenia (HP:0001875)1.95650853
68Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94586678
69Constricted visual fields (HP:0001133)1.93854958
70Abnormal biliary tract physiology (HP:0012439)1.93378025
71Bile duct proliferation (HP:0001408)1.93378025
72Increased CSF protein (HP:0002922)1.91984165
73Abnormality of transition element cation homeostasis (HP:0011030)1.91704435
74Aplastic anemia (HP:0001915)1.90999382
75Facial diplegia (HP:0001349)1.90970810
76Abnormal pancreas size (HP:0012094)1.90185205
77Granulocytopenia (HP:0001913)1.89627214
78Petechiae (HP:0000967)1.89462911
79Proximal tubulopathy (HP:0000114)1.88212092
80Abnormality of male internal genitalia (HP:0000022)1.88211232
81Prolonged bleeding time (HP:0003010)1.87343662
82Hypoplasia of the uterus (HP:0000013)1.84984098
83IgA deficiency (HP:0002720)1.84307573
84Keratoconjunctivitis (HP:0001096)1.84273051
85Lymphopenia (HP:0001888)1.81119618
86Lymphoma (HP:0002665)1.77500436
87Abnormality of macrophages (HP:0004311)1.77409660
88Abnormal albumin level (HP:0012116)1.73720585
89Hypoalbuminemia (HP:0003073)1.73720585
90Hemoptysis (HP:0002105)1.73616388
91Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72067162
92Keratoconjunctivitis sicca (HP:0001097)1.71829220
93Abnormality of cells of the lymphoid lineage (HP:0012140)1.71461028
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70028546
95Abnormal protein N-linked glycosylation (HP:0012347)1.70028546
96Abnormal protein glycosylation (HP:0012346)1.70028546
97Abnormal glycosylation (HP:0012345)1.70028546
98Abnormality of the fovea (HP:0000493)1.69718102
99Nausea (HP:0002018)1.68570764
100Eczematoid dermatitis (HP:0000976)1.67445285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.61869174
2MAP4K13.74569537
3MST43.38041709
4FRK3.07849644
5NUAK12.57293698
6BLK2.56235431
7ACVR1B2.29610189
8TAOK32.25128602
9TEC2.17164648
10IRAK41.98359494
11GRK11.96430844
12ITK1.95429550
13MAP4K21.88820935
14EIF2AK31.86803996
15JAK31.82158526
16AKT31.82047466
17IKBKB1.76877285
18MAP3K141.70755063
19BRSK21.64947880
20BTK1.64196093
21SYK1.62544089
22ZAK1.60963098
23CAMKK21.60897976
24MARK31.60846787
25FES1.60825295
26ZAP701.55138529
27TNK21.54988453
28IKBKE1.49978281
29GRK61.48798266
30ADRBK21.47404171
31TBK11.43603229
32TYK21.34243274
33PIK3CG1.33654208
34PRKCQ1.32836044
35KIT1.24366521
36MAP3K121.20968426
37JAK11.19635846
38RIPK41.15564226
39MAPKAPK31.15050159
40NLK1.14567431
41LYN1.07665389
42BMPR1B1.06114668
43STK31.03021390
44TNIK1.02819328
45LCK1.02445230
46CSK1.02051403
47CSF1R0.97530207
48WNK40.97181490
49PIM10.90366707
50SIK30.88497556
51MATK0.88161080
52OXSR10.86383433
53HCK0.85484214
54PTK2B0.83409648
55STK100.82993641
56MAP2K60.81365557
57PRKCI0.78970570
58WNK30.78525485
59BMPR20.78389964
60PLK40.77122263
61PDK10.76131426
62PDK20.75741108
63GRK70.65492111
64BUB10.60362044
65PBK0.58784580
66CHUK0.56718341
67LATS10.55752898
68TAF10.55103885
69STK390.50880702
70TRIM280.48484563
71BRSK10.47945535
72MAP2K20.47698863
73TLK10.45777221
74ABL10.45294832
75CDK90.45092755
76TESK20.44084857
77MAPK110.43681482
78MAP3K110.43681091
79CDK40.43495697
80TRPM70.42774802
81IRAK10.41156930
82MAP3K130.40132861
83MAPKAPK20.39938821
84MELK0.38310711
85FGR0.35566251
86EIF2AK20.33835485
87PRKCE0.32639956
88STK40.31963134
89RPS6KA50.31583430
90CDC42BPA0.31099266
91NEK60.31015601
92PAK30.30778960
93ADRBK10.29620207
94ATR0.29076600
95PASK0.28930944
96PDPK10.28355575
97MAPKAPK50.27888232
98JAK20.26898156
99IGF1R0.25758013
100PRKG20.25665014

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.71997223
2Graft-versus-host disease_Homo sapiens_hsa053323.51646944
3Allograft rejection_Homo sapiens_hsa053303.23608796
4Autoimmune thyroid disease_Homo sapiens_hsa053203.05721177
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.86889869
6Type I diabetes mellitus_Homo sapiens_hsa049402.68679549
7Asthma_Homo sapiens_hsa053102.35413452
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.27114028
9Antigen processing and presentation_Homo sapiens_hsa046122.26530141
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15883309
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.97453880
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82731266
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.79879944
14Proteasome_Homo sapiens_hsa030501.75946587
15Linoleic acid metabolism_Homo sapiens_hsa005911.72310999
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68443027
17Hematopoietic cell lineage_Homo sapiens_hsa046401.66730191
18T cell receptor signaling pathway_Homo sapiens_hsa046601.59542615
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58352260
20RNA polymerase_Homo sapiens_hsa030201.57026332
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.55121513
22Regulation of autophagy_Homo sapiens_hsa041401.53598842
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51769758
24Measles_Homo sapiens_hsa051621.50786383
25RNA degradation_Homo sapiens_hsa030181.46985785
26Leishmaniasis_Homo sapiens_hsa051401.45996684
27Staphylococcus aureus infection_Homo sapiens_hsa051501.43157801
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40031579
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38128603
30Herpes simplex infection_Homo sapiens_hsa051681.33843182
31Rheumatoid arthritis_Homo sapiens_hsa053231.33690177
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30793972
33Ether lipid metabolism_Homo sapiens_hsa005651.29646846
34Basal transcription factors_Homo sapiens_hsa030221.26397136
35Sulfur metabolism_Homo sapiens_hsa009201.24949363
36Caffeine metabolism_Homo sapiens_hsa002321.22850540
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.19247082
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.14879710
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13490896
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10062650
41Nitrogen metabolism_Homo sapiens_hsa009101.09877557
42Legionellosis_Homo sapiens_hsa051341.06456734
43Protein export_Homo sapiens_hsa030601.03097367
44Selenocompound metabolism_Homo sapiens_hsa004501.03057194
45B cell receptor signaling pathway_Homo sapiens_hsa046620.99236338
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99100244
47Homologous recombination_Homo sapiens_hsa034400.98180173
48Vitamin digestion and absorption_Homo sapiens_hsa049770.97695975
49Phototransduction_Homo sapiens_hsa047440.97106574
50Arachidonic acid metabolism_Homo sapiens_hsa005900.96607048
51Osteoclast differentiation_Homo sapiens_hsa043800.91092984
52Tuberculosis_Homo sapiens_hsa051520.89900666
53Viral myocarditis_Homo sapiens_hsa054160.86925552
54Fanconi anemia pathway_Homo sapiens_hsa034600.85385609
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81904258
56Propanoate metabolism_Homo sapiens_hsa006400.81324602
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79385431
58Influenza A_Homo sapiens_hsa051640.79222669
59Fat digestion and absorption_Homo sapiens_hsa049750.78685998
60Fatty acid elongation_Homo sapiens_hsa000620.76033732
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73654689
62African trypanosomiasis_Homo sapiens_hsa051430.71998757
63Chemical carcinogenesis_Homo sapiens_hsa052040.70181895
64p53 signaling pathway_Homo sapiens_hsa041150.69050217
65Epstein-Barr virus infection_Homo sapiens_hsa051690.67766765
66Olfactory transduction_Homo sapiens_hsa047400.67527797
67Retinol metabolism_Homo sapiens_hsa008300.64132913
68Toxoplasmosis_Homo sapiens_hsa051450.63371533
69Peroxisome_Homo sapiens_hsa041460.62739987
70TNF signaling pathway_Homo sapiens_hsa046680.62636568
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.59758168
72Pyrimidine metabolism_Homo sapiens_hsa002400.59165190
73Oxidative phosphorylation_Homo sapiens_hsa001900.57061797
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54966771
75RNA transport_Homo sapiens_hsa030130.54575361
76Glutathione metabolism_Homo sapiens_hsa004800.52973407
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52034363
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51772495
79Tryptophan metabolism_Homo sapiens_hsa003800.51555165
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51380577
81Mineral absorption_Homo sapiens_hsa049780.49556946
82Butanoate metabolism_Homo sapiens_hsa006500.48437838
83Purine metabolism_Homo sapiens_hsa002300.48017223
84Hepatitis C_Homo sapiens_hsa051600.45336185
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45074257
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.44649368
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.43694257
88Chemokine signaling pathway_Homo sapiens_hsa040620.41996673
89Circadian rhythm_Homo sapiens_hsa047100.40021046
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39696526
91Platelet activation_Homo sapiens_hsa046110.39176811
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38621513
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.36936328
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36482720
95Inositol phosphate metabolism_Homo sapiens_hsa005620.35402244
96Apoptosis_Homo sapiens_hsa042100.34688349
97Collecting duct acid secretion_Homo sapiens_hsa049660.33855952
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33318041
99Nucleotide excision repair_Homo sapiens_hsa034200.32645816
100Hepatitis B_Homo sapiens_hsa051610.32603292

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