ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of cytosolic calcium ion concentration (GO:0051481)	8.02660970
2	piRNA metabolic process (GO:0034587)	6.30903682
3	response to pheromone (GO:0019236)	6.17934575
4	behavioral response to ethanol (GO:0048149)	5.25827471
5	negative regulation of cAMP-mediated signaling (GO:0043951)	5.25154483
6	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.92965204
7	substrate-independent telencephalic tangential migration (GO:0021826)	4.92965204
8	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	4.54780175
9	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	4.54780175
10	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	4.40684310
11	opioid receptor signaling pathway (GO:0038003)	4.40367864
12	protein localization to synapse (GO:0035418)	4.37140275
13	righting reflex (GO:0060013)	4.29622298
14	startle response (GO:0001964)	4.28814067
15	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	4.20585509
16	positive regulation of mitochondrial fission (GO:0090141)	3.95611553
17	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.90302802
18	DNA methylation involved in gamete generation (GO:0043046)	3.81489970
19	postsynaptic membrane organization (GO:0001941)	3.80126348
20	cerebral cortex radially oriented cell migration (GO:0021799)	3.79027386
21	ether lipid metabolic process (GO:0046485)	3.72595467
22	nonmotile primary cilium assembly (GO:0035058)	3.61891788
23	protein-cofactor linkage (GO:0018065)	3.61499418
24	reflex (GO:0060004)	3.52698424
25	adult feeding behavior (GO:0008343)	3.51230259
26	regulation of protein glycosylation (GO:0060049)	3.43262209
27	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.41562192
28	dopamine transport (GO:0015872)	3.38273128
29	glycosphingolipid biosynthetic process (GO:0006688)	3.35290888
30	regulation of acrosome reaction (GO:0060046)	3.35095075
31	vocalization behavior (GO:0071625)	3.33324626
32	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.32874954
33	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.32346244
34	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.32109408
35	male meiosis (GO:0007140)	3.15641513
36	regulation of meiosis I (GO:0060631)	3.14922442
37	auditory receptor cell stereocilium organization (GO:0060088)	3.11590637
38	cellular ketone body metabolic process (GO:0046950)	3.09296461
39	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.08201679
40	presynaptic membrane organization (GO:0097090)	3.04893818
41	neuronal action potential propagation (GO:0019227)	3.04632122
42	male meiosis I (GO:0007141)	3.02058188
43	regulation of collateral sprouting (GO:0048670)	3.00639076
44	secondary heart field specification (GO:0003139)	3.00219880
45	heart field specification (GO:0003128)	3.00219880
46	cAMP catabolic process (GO:0006198)	2.98141534
47	synaptonemal complex organization (GO:0070193)	2.97525695
48	photoreceptor cell maintenance (GO:0045494)	2.96521958
49	gamma-aminobutyric acid transport (GO:0015812)	2.90998001
50	presynaptic membrane assembly (GO:0097105)	2.89581402
51	regulation of glutamate receptor signaling pathway (GO:1900449)	2.89562431
52	intraciliary transport (GO:0042073)	2.89351871
53	synaptic vesicle maturation (GO:0016188)	2.88931604
54	respiratory chain complex IV assembly (GO:0008535)	2.87430119
55	pyrimidine dimer repair (GO:0006290)	2.86919512
56	detection of light stimulus involved in visual perception (GO:0050908)	2.85838075
57	detection of light stimulus involved in sensory perception (GO:0050962)	2.85838075
58	coenzyme catabolic process (GO:0009109)	2.85242533
59	transmission of nerve impulse (GO:0019226)	2.84422675
60	cyclic nucleotide catabolic process (GO:0009214)	2.82573798
61	cornea development in camera-type eye (GO:0061303)	2.78787748
62	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.75961543
63	ketone body metabolic process (GO:1902224)	2.75414697
64	membrane depolarization during action potential (GO:0086010)	2.74932537
65	regulation of neurotransmitter uptake (GO:0051580)	2.74154064
66	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.71179547
67	synaptic vesicle endocytosis (GO:0048488)	2.68021908
68	chromosome organization involved in meiosis (GO:0070192)	2.67135131
69	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	2.65684463
70	meiotic nuclear division (GO:0007126)	2.65115017
71	establishment of mitochondrion localization (GO:0051654)	2.64996781
72	regulation of translational termination (GO:0006449)	2.64490561
73	regulation of mitochondrial fission (GO:0090140)	2.63102859
74	prenylation (GO:0097354)	2.62273301
75	protein prenylation (GO:0018342)	2.62273301
76	cartilage morphogenesis (GO:0060536)	2.62080559
77	positive regulation of meiosis (GO:0045836)	2.61422389
78	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	2.61255151
79	inner ear receptor stereocilium organization (GO:0060122)	2.60693688
80	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.60381494
81	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.59750897
82	phosphorelay signal transduction system (GO:0000160)	2.58088264
83	cytochrome complex assembly (GO:0017004)	2.57953693
84	positive regulation of cAMP-mediated signaling (GO:0043950)	2.57815269
85	axoneme assembly (GO:0035082)	2.55115450
86	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.53910570
87	neuron cell-cell adhesion (GO:0007158)	2.53434889
88	regulation of Rac GTPase activity (GO:0032314)	2.53363997
89	C4-dicarboxylate transport (GO:0015740)	2.53005292
90	detection of mechanical stimulus (GO:0050982)	2.52226064
91	membrane hyperpolarization (GO:0060081)	2.49359279
92	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.48883706
93	positive regulation of meiotic cell cycle (GO:0051446)	2.48829064
94	protein localization to cilium (GO:0061512)	2.48558592
95	negative regulation of Rho protein signal transduction (GO:0035024)	2.48316861
96	positive regulation of synapse assembly (GO:0051965)	2.47852362
97	epithelial cilium movement (GO:0003351)	2.47851821
98	aspartate family amino acid catabolic process (GO:0009068)	2.47817810
99	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	2.46179313
100	positive regulation of membrane potential (GO:0045838)	2.46033770

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.90707630
2	VDR_22108803_ChIP-Seq_LS180_Human	2.97398996
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.97059590
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.71755672
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.54155028
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.51406630
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.41596075
8	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.32637096
9	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.32637096
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.31329256
11	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.23925270
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.14109563
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.10772028
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.96094405
15	P300_19829295_ChIP-Seq_ESCs_Human	1.93551953
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.89685989
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.87627434
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86551534
19	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.86113835
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.81249225
21	TCF4_23295773_ChIP-Seq_U87_Human	1.75668873
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.74953508
23	STAT3_23295773_ChIP-Seq_U87_Human	1.74943947
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.74647094
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.73162802
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72518983
27	FUS_26573619_Chip-Seq_HEK293_Human	1.68665070
28	EWS_26573619_Chip-Seq_HEK293_Human	1.62288574
29	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.61590603
30	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.60697996
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.59692223
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57981475
33	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.57616287
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.57383945
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.57100252
36	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.56031294
37	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.52526373
38	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.51900782
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.50435834
40	NANOG_19829295_ChIP-Seq_ESCs_Human	1.50435834
41	AR_21572438_ChIP-Seq_LNCaP_Human	1.50155392
42	AR_25329375_ChIP-Seq_VCAP_Human	1.49685760
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49038450
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.49038450
45	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.47958814
46	RUNX2_22187159_ChIP-Seq_PCA_Human	1.46172380
47	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.44828376
48	RXR_22108803_ChIP-Seq_LS180_Human	1.43794461
49	RNF2_27304074_Chip-Seq_NSC_Mouse	1.43784924
50	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.41833434
51	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.41645144
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40860525
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39319585
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39249596
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38905871
56	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.37734951
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35746235
58	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.35580957
59	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35375286
60	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.32566115
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32307024
62	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.30217013
63	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29307847
64	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.28754092
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28216610
66	TP53_16413492_ChIP-PET_HCT116_Human	1.27154639
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26283357
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.26207151
69	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.25681163
70	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25364312
71	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.23334462
72	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.22029734
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.20907018
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19633433
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19102559
76	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14339660
77	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.14276418
78	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.13493690
79	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12626823
80	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.12334133
81	TCF4_22108803_ChIP-Seq_LS180_Human	1.12292094
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11354211
83	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.11212569
84	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11073643
85	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.10971125
86	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.09630071
87	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08834300
88	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05747111
89	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.05713791
90	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.05713791
91	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.05584550
92	DROSHA_22980978_ChIP-Seq_HELA_Human	1.04636129
93	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.04622951
94	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.04374078
95	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.02851464
96	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02025568
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01224213
98	KDM2B_26808549_Chip-Seq_REH_Human	1.00368533
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99344390
100	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98839568

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	4.70233710
2	MP0003646_muscle_fatigue	4.06740988
3	MP0003880_abnormal_central_pattern	3.51306864
4	MP0001968_abnormal_touch/_nociception	3.14493608
5	MP0004859_abnormal_synaptic_plasticity	2.63053927
6	MP0001529_abnormal_vocalization	2.62712025
7	MP0002876_abnormal_thyroid_physiology	2.61978577
8	MP0004145_abnormal_muscle_electrophysio	2.58291484
9	MP0005423_abnormal_somatic_nervous	2.36504711
10	MP0009046_muscle_twitch	2.35746184
11	MP0001984_abnormal_olfaction	2.28350242
12	MP0008877_abnormal_DNA_methylation	2.24267830
13	MP0000751_myopathy	2.13306482
14	MP0002102_abnormal_ear_morphology	2.10506190
15	MP0005551_abnormal_eye_electrophysiolog	2.09067238
16	MP0009780_abnormal_chondrocyte_physiolo	2.05948298
17	MP0003635_abnormal_synaptic_transmissio	2.03503863
18	MP0003950_abnormal_plasma_membrane	2.01326261
19	MP0001486_abnormal_startle_reflex	2.00665243
20	MP0009745_abnormal_behavioral_response	2.00032753
21	MP0004742_abnormal_vestibular_system	1.98545724
22	MP0002736_abnormal_nociception_after	1.97967737
23	MP0002249_abnormal_larynx_morphology	1.92671997
24	MP0002272_abnormal_nervous_system	1.87806903
25	MP0003122_maternal_imprinting	1.85138714
26	MP0004142_abnormal_muscle_tone	1.75095444
27	MP0008995_early_reproductive_senescence	1.69250323
28	MP0005645_abnormal_hypothalamus_physiol	1.66712847
29	MP0003941_abnormal_skin_development	1.57763018
30	MP0001501_abnormal_sleep_pattern	1.56027316
31	MP0002063_abnormal_learning/memory/cond	1.56007196
32	MP0003221_abnormal_cardiomyocyte_apopto	1.50866634
33	MP0008875_abnormal_xenobiotic_pharmacok	1.46585597
34	MP0006276_abnormal_autonomic_nervous	1.46331643
35	MP0002735_abnormal_chemical_nociception	1.40236582
36	MP0002733_abnormal_thermal_nociception	1.38707949
37	MP0002064_seizures	1.36057905
38	MP0003045_fibrosis	1.33538592
39	MP0002638_abnormal_pupillary_reflex	1.32918020
40	MP0001661_extended_life_span	1.32833300
41	MP0003937_abnormal_limbs/digits/tail_de	1.27778660
42	MP0004811_abnormal_neuron_physiology	1.27614225
43	MP0004924_abnormal_behavior	1.26696258
44	MP0005386_behavior/neurological_phenoty	1.26696258
45	MP0000579_abnormal_nail_morphology	1.26199673
46	MP0001970_abnormal_pain_threshold	1.25504267
47	MP0002572_abnormal_emotion/affect_behav	1.24999164
48	MP0003787_abnormal_imprinting	1.24863048
49	MP0002557_abnormal_social/conspecific_i	1.20907043
50	MP0004215_abnormal_myocardial_fiber	1.20301629
51	MP0002234_abnormal_pharynx_morphology	1.17630184
52	MP0002282_abnormal_trachea_morphology	1.15933057
53	MP0005646_abnormal_pituitary_gland	1.15541073
54	MP0000678_abnormal_parathyroid_gland	1.14269008
55	MP0006035_abnormal_mitochondrial_morpho	1.12849431
56	MP0001502_abnormal_circadian_rhythm	1.11788312
57	MP0003121_genomic_imprinting	1.09427224
58	MP0005253_abnormal_eye_physiology	1.09344790
59	MP0003195_calcinosis	1.07090812
60	MP0003183_abnormal_peptide_metabolism	1.06467397
61	MP0002067_abnormal_sensory_capabilities	1.04958011
62	MP0000749_muscle_degeneration	1.04450703
63	MP0003011_delayed_dark_adaptation	1.02376684
64	MP0004885_abnormal_endolymph	1.01754003
65	MP0000569_abnormal_digit_pigmentation	1.01504189
66	MP0001905_abnormal_dopamine_level	1.01404422
67	MP0004147_increased_porphyrin_level	0.97593326
68	MP0003698_abnormal_male_reproductive	0.97398301
69	MP0005085_abnormal_gallbladder_physiolo	0.95786114
70	MP0000383_abnormal_hair_follicle	0.95455476
71	MP0002734_abnormal_mechanical_nocicepti	0.95383999
72	MP0001963_abnormal_hearing_physiology	0.94597585
73	MP0000778_abnormal_nervous_system	0.94581620
74	MP0001485_abnormal_pinna_reflex	0.94240412
75	MP0004036_abnormal_muscle_relaxation	0.92782613
76	MP0002909_abnormal_adrenal_gland	0.92630269
77	MP0000049_abnormal_middle_ear	0.91614994
78	MP0002160_abnormal_reproductive_system	0.90667515
79	MP0008775_abnormal_heart_ventricle	0.86770626
80	MP0002210_abnormal_sex_determination	0.86157071
81	MP0004484_altered_response_of	0.84773940
82	MP0001664_abnormal_digestion	0.83815657
83	MP0003633_abnormal_nervous_system	0.79276098
84	MP0002066_abnormal_motor_capabilities/c	0.79169049
85	MP0000427_abnormal_hair_cycle	0.78667168
86	MP0002184_abnormal_innervation	0.78035182
87	MP0004085_abnormal_heartbeat	0.77295807
88	MP0004233_abnormal_muscle_weight	0.76649671
89	MP0001929_abnormal_gametogenesis	0.76517833
90	MP0003119_abnormal_digestive_system	0.76363777
91	MP0005503_abnormal_tendon_morphology	0.74719851
92	MP0002882_abnormal_neuron_morphology	0.73988845
93	MP0002168_other_aberrant_phenotype	0.73256792
94	MP0003755_abnormal_palate_morphology	0.72478756
95	MP0002090_abnormal_vision	0.72247091
96	MP0000631_abnormal_neuroendocrine_gland	0.70467300
97	MP0005195_abnormal_posterior_eye	0.70388185
98	MP0002752_abnormal_somatic_nervous	0.69060518
99	MP0008789_abnormal_olfactory_epithelium	0.67520844
100	MP0002108_abnormal_muscle_morphology	0.67453114

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Thyroid-stimulating hormone excess (HP:0002925)	6.34048574
2	Focal motor seizures (HP:0011153)	4.36027242
3	Hyperventilation (HP:0002883)	4.28670489
4	Atonic seizures (HP:0010819)	4.02487449
5	Volvulus (HP:0002580)	3.69828312
6	Focal seizures (HP:0007359)	3.68720577
7	Type II lissencephaly (HP:0007260)	3.33012454
8	Agitation (HP:0000713)	3.28658724
9	Limb dystonia (HP:0002451)	3.08723873
10	Dialeptic seizures (HP:0011146)	3.03590669
11	Lissencephaly (HP:0001339)	2.94138299
12	Febrile seizures (HP:0002373)	2.93703792
13	Generalized tonic-clonic seizures (HP:0002069)	2.84206885
14	Nephrogenic diabetes insipidus (HP:0009806)	2.82812694
15	Poor head control (HP:0002421)	2.71997157
16	Status epilepticus (HP:0002133)	2.66690205
17	Gait imbalance (HP:0002141)	2.65327639
18	Medial flaring of the eyebrow (HP:0010747)	2.63234465
19	Absence seizures (HP:0002121)	2.62222691
20	Dysdiadochokinesis (HP:0002075)	2.61952782
21	Calf muscle hypertrophy (HP:0008981)	2.61090679
22	Intestinal atresia (HP:0011100)	2.59517901
23	Supernumerary spleens (HP:0009799)	2.59489311
24	Broad-based gait (HP:0002136)	2.49685302
25	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.47832170
26	Hypoplasia of the brainstem (HP:0002365)	2.47832170
27	Congenital primary aphakia (HP:0007707)	2.47368495
28	Absent speech (HP:0001344)	2.46117380
29	Epileptic encephalopathy (HP:0200134)	2.45431259
30	Retinal dysplasia (HP:0007973)	2.43263931
31	Optic nerve hypoplasia (HP:0000609)	2.41705268
32	Hip dysplasia (HP:0001385)	2.39845483
33	Abnormality of macular pigmentation (HP:0008002)	2.38160830
34	Broad alveolar ridges (HP:0000187)	2.35707902
35	Gaze-evoked nystagmus (HP:0000640)	2.35436008
36	Abnormality of the labia minora (HP:0012880)	2.34350108
37	Hepatoblastoma (HP:0002884)	2.34001964
38	Muscle hypertrophy of the lower extremities (HP:0008968)	2.33063075
39	Hyperglycinuria (HP:0003108)	2.32418341
40	Pancreatic islet-cell hyperplasia (HP:0004510)	2.29855482
41	Abnormality of the aortic arch (HP:0012303)	2.29346165
42	Pancreatic cysts (HP:0001737)	2.23370267
43	Decreased circulating renin level (HP:0003351)	2.22586105
44	Abnormality of midbrain morphology (HP:0002418)	2.22185870
45	Molar tooth sign on MRI (HP:0002419)	2.22185870
46	Pancreatic fibrosis (HP:0100732)	2.21955114
47	Shoulder girdle muscle weakness (HP:0003547)	2.21728736
48	Hepatocellular necrosis (HP:0001404)	2.21498358
49	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.17949787
50	Cutaneous melanoma (HP:0012056)	2.15988018
51	Congenital stationary night blindness (HP:0007642)	2.15319064
52	Vaginal atresia (HP:0000148)	2.11679679
53	Tubular atrophy (HP:0000092)	2.10241686
54	Polydipsia (HP:0001959)	2.09615754
55	Abnormal drinking behavior (HP:0030082)	2.09615754
56	Polyphagia (HP:0002591)	2.09392647
57	Hypothermia (HP:0002045)	2.08143846
58	Genital tract atresia (HP:0001827)	2.06903103
59	Nephronophthisis (HP:0000090)	2.05800493
60	Hepatic necrosis (HP:0002605)	2.05295752
61	Bifid tongue (HP:0010297)	2.04621995
62	Oligodactyly (hands) (HP:0001180)	2.01016798
63	Ketoacidosis (HP:0001993)	1.98717613
64	Neonatal respiratory distress (HP:0002643)	1.96474591
65	3-Methylglutaconic aciduria (HP:0003535)	1.96077108
66	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.95872202
67	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.95872202
68	Acute necrotizing encephalopathy (HP:0006965)	1.95530079
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.95495141
70	Abnormality of endocrine pancreas physiology (HP:0012093)	1.95418997
71	Abnormality of the pancreatic islet cells (HP:0006476)	1.95418997
72	Decreased lacrimation (HP:0000633)	1.95301200
73	EEG with generalized epileptiform discharges (HP:0011198)	1.94243808
74	Hypsarrhythmia (HP:0002521)	1.93413928
75	Alacrima (HP:0000522)	1.93400157
76	Abnormality of the renal medulla (HP:0100957)	1.92897546
77	Poor coordination (HP:0002370)	1.92055257
78	Epileptiform EEG discharges (HP:0011182)	1.91434313
79	Horizontal nystagmus (HP:0000666)	1.91143825
80	Thickened helices (HP:0000391)	1.90747607
81	Abnormality of the calf musculature (HP:0001430)	1.89964313
82	Split foot (HP:0001839)	1.89237007
83	Increased density of long bones (HP:0006392)	1.88435897
84	Muscular dystrophy (HP:0003560)	1.87289252
85	Abnormality of the renal cortex (HP:0011035)	1.86915389
86	True hermaphroditism (HP:0010459)	1.86337148
87	Cystic liver disease (HP:0006706)	1.86006019
88	Cerebellar dysplasia (HP:0007033)	1.85545612
89	Amyotrophic lateral sclerosis (HP:0007354)	1.84800754
90	Gonadotropin excess (HP:0000837)	1.84708501
91	Progressive macrocephaly (HP:0004481)	1.83823633
92	Hyperpituitarism (HP:0010514)	1.83730590
93	Large for gestational age (HP:0001520)	1.83433748
94	Hypokalemic alkalosis (HP:0001949)	1.83425970
95	Increased CSF lactate (HP:0002490)	1.82738612
96	Restlessness (HP:0000711)	1.82636767
97	Drooling (HP:0002307)	1.81966890
98	Inability to walk (HP:0002540)	1.80231078
99	Poor speech (HP:0002465)	1.79212999
100	Narrow forehead (HP:0000341)	1.78511731

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	4.13639940
2	PINK1	3.85617367
3	ADRBK2	3.67132731
4	FRK	3.26009148
5	MAP3K4	2.89301189
6	PNCK	2.87494410
7	MAPK13	2.43921808
8	MAP4K2	2.42821861
9	CAMK1G	2.16667501
10	EPHA4	2.15420436
11	MARK1	2.05930645
12	TRIM28	2.01686205
13	MAP2K7	1.94233753
14	INSRR	1.91076378
15	PAK6	1.90173616
16	PTK2B	1.73530493
17	PAK3	1.69727438
18	MET	1.56353324
19	PLK2	1.49704502
20	ADRBK1	1.47385220
21	STK38L	1.44141802
22	CAMK1	1.44073414
23	PKN1	1.40634363
24	CAMK1D	1.39618874
25	OXSR1	1.39371668
26	BMPR1B	1.37801270
27	CDK19	1.36605130
28	BCR	1.33449420
29	PRKCG	1.32394977
30	FGR	1.27297424
31	MAP2K4	1.23523292
32	BRSK2	1.20467155
33	BCKDK	1.18924726
34	PRKCE	1.17857403
35	OBSCN	1.17402963
36	CAMK4	1.10726055
37	PIK3CG	1.05820432
38	DYRK1A	1.04772110
39	CAMK2B	1.02549754
40	CAMK2A	1.02353677
41	PRKAA1	1.01747049
42	ACVR1B	0.99981306
43	CAMKK2	0.99874624
44	PLK4	0.99436291
45	CCNB1	0.97886330
46	MAP3K7	0.97327571
47	CSNK1G1	0.96842667
48	WNK3	0.93771679
49	PHKG1	0.93722798
50	PHKG2	0.93722798
51	GRK7	0.91775616
52	NTRK2	0.91297080
53	KSR1	0.89694067
54	STK38	0.87733460
55	TSSK6	0.84742842
56	MAP3K2	0.83254335
57	CSNK1A1L	0.77880512
58	MAP3K6	0.74998632
59	MST4	0.74396766
60	TRPM7	0.73190926
61	WEE1	0.72770853
62	CAMK2D	0.69400848
63	PRKD2	0.69117481
64	RPS6KA4	0.69012634
65	CSNK1G3	0.68651200
66	PRKAA2	0.68233738
67	CAMK2G	0.67764065
68	MAPKAPK5	0.67578388
69	GRK1	0.67481102
70	NUAK1	0.65569141
71	MAP3K5	0.64988173
72	CSNK1G2	0.64762583
73	TNIK	0.62157789
74	BRSK1	0.61024182
75	IRAK1	0.60725295
76	ERBB3	0.60211863
77	CDK5	0.58120446
78	STK39	0.57879677
79	LIMK1	0.54731617
80	MAPKAPK3	0.49192195
81	SGK2	0.48633052
82	UHMK1	0.48070021
83	SGK1	0.47467162
84	PKN2	0.47381707
85	PRKCI	0.46515692
86	BMX	0.46100864
87	DYRK3	0.45312217
88	RAF1	0.43185313
89	MKNK2	0.42198990
90	FLT3	0.40817670
91	NLK	0.36834939
92	FER	0.36422611
93	RPS6KB1	0.35860472
94	MINK1	0.35222482
95	CDK11A	0.34716253
96	MUSK	0.34448227
97	RET	0.33874321
98	TGFBR2	0.32879396
99	PRKACA	0.32811306
100	CSNK1E	0.29784153

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	3.79482751
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.89176748
3	Nicotine addiction_Homo sapiens_hsa05033	2.74247513
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.68917856
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.49648487
6	Phototransduction_Homo sapiens_hsa04744	2.48248465
7	Olfactory transduction_Homo sapiens_hsa04740	2.47257548
8	Butanoate metabolism_Homo sapiens_hsa00650	2.24601069
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.20970928
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.20531213
11	Taste transduction_Homo sapiens_hsa04742	2.15768527
12	Morphine addiction_Homo sapiens_hsa05032	2.09028378
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.89620151
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.76655057
15	Circadian rhythm_Homo sapiens_hsa04710	1.72613589
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.69649678
17	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.64739491
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.61218744
19	Glutamatergic synapse_Homo sapiens_hsa04724	1.56453653
20	Glycerolipid metabolism_Homo sapiens_hsa00561	1.49946871
21	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.48592507
22	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.46326378
23	Protein export_Homo sapiens_hsa03060	1.40945736
24	beta-Alanine metabolism_Homo sapiens_hsa00410	1.40892711
25	Propanoate metabolism_Homo sapiens_hsa00640	1.40051276
26	Circadian entrainment_Homo sapiens_hsa04713	1.39315813
27	Insulin secretion_Homo sapiens_hsa04911	1.31504490
28	Dopaminergic synapse_Homo sapiens_hsa04728	1.28686542
29	GABAergic synapse_Homo sapiens_hsa04727	1.24885169
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.23437800
31	Cocaine addiction_Homo sapiens_hsa05030	1.22726276
32	Calcium signaling pathway_Homo sapiens_hsa04020	1.18701521
33	Regulation of autophagy_Homo sapiens_hsa04140	1.16001933
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.15910651
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.13678698
36	Arginine and proline metabolism_Homo sapiens_hsa00330	1.10840521
37	Amphetamine addiction_Homo sapiens_hsa05031	1.08615863
38	Basal transcription factors_Homo sapiens_hsa03022	1.05558602
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.03523435
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02017300
41	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.01535719
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.01445594
43	Cardiac muscle contraction_Homo sapiens_hsa04260	1.00979688
44	RNA degradation_Homo sapiens_hsa03018	1.00416443
45	ABC transporters_Homo sapiens_hsa02010	0.97462591
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.97301835
47	Histidine metabolism_Homo sapiens_hsa00340	0.96715310
48	Serotonergic synapse_Homo sapiens_hsa04726	0.92074481
49	Salivary secretion_Homo sapiens_hsa04970	0.84715209
50	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.83339822
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82958298
52	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.81947465
53	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.81616576
54	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.78568592
55	Parkinsons disease_Homo sapiens_hsa05012	0.78256277
56	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.76536937
57	Fatty acid degradation_Homo sapiens_hsa00071	0.74221689
58	Oxidative phosphorylation_Homo sapiens_hsa00190	0.70972272
59	Homologous recombination_Homo sapiens_hsa03440	0.70227516
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69569917
61	Basal cell carcinoma_Homo sapiens_hsa05217	0.69406353
62	Sphingolipid metabolism_Homo sapiens_hsa00600	0.67418817
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67021070
64	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.66708202
65	cAMP signaling pathway_Homo sapiens_hsa04024	0.66062909
66	Huntingtons disease_Homo sapiens_hsa05016	0.65530073
67	Choline metabolism in cancer_Homo sapiens_hsa05231	0.64401062
68	Retinol metabolism_Homo sapiens_hsa00830	0.64301664
69	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.64166488
70	Long-term depression_Homo sapiens_hsa04730	0.64163711
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61990509
72	Type II diabetes mellitus_Homo sapiens_hsa04930	0.61236939
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60321880
74	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.57624605
75	Hippo signaling pathway_Homo sapiens_hsa04390	0.57522049
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57001935
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53056637
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.52819750
79	Glucagon signaling pathway_Homo sapiens_hsa04922	0.52662751
80	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.52027270
81	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.51499638
82	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.50976359
83	Oocyte meiosis_Homo sapiens_hsa04114	0.50242521
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46358314
85	Mineral absorption_Homo sapiens_hsa04978	0.45210334
86	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.44731538
87	Metabolic pathways_Homo sapiens_hsa01100	0.42648400
88	mRNA surveillance pathway_Homo sapiens_hsa03015	0.42358858
89	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.42217456
90	RNA polymerase_Homo sapiens_hsa03020	0.42182766
91	Nitrogen metabolism_Homo sapiens_hsa00910	0.42136105
92	Wnt signaling pathway_Homo sapiens_hsa04310	0.41900310
93	Renin secretion_Homo sapiens_hsa04924	0.41594205
94	Cholinergic synapse_Homo sapiens_hsa04725	0.41541761
95	Pancreatic secretion_Homo sapiens_hsa04972	0.41305998
96	Peroxisome_Homo sapiens_hsa04146	0.40474469
97	Alzheimers disease_Homo sapiens_hsa05010	0.39780042
98	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.39160109
99	Long-term potentiation_Homo sapiens_hsa04720	0.36788458
100	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.36125766

ZNF603P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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