ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.35250142
2	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.79431095
3	regulation of translation, ncRNA-mediated (GO:0045974)	3.79431095
4	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.79431095
5	kidney morphogenesis (GO:0060993)	3.66055194
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.59653007
7	response to pheromone (GO:0019236)	3.59149974
8	fucose catabolic process (GO:0019317)	3.58485092
9	L-fucose metabolic process (GO:0042354)	3.58485092
10	L-fucose catabolic process (GO:0042355)	3.58485092
11	pyrimidine nucleobase catabolic process (GO:0006208)	3.53979728
12	indolalkylamine catabolic process (GO:0046218)	3.40086007
13	tryptophan catabolic process (GO:0006569)	3.40086007
14	indole-containing compound catabolic process (GO:0042436)	3.40086007
15	presynaptic membrane assembly (GO:0097105)	3.36437857
16	neural tube formation (GO:0001841)	3.35448657
17	kynurenine metabolic process (GO:0070189)	3.33812482
18	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.32674183
19	limb bud formation (GO:0060174)	3.22453903
20	postsynaptic membrane organization (GO:0001941)	3.12732492
21	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.08264628
22	presynaptic membrane organization (GO:0097090)	3.07812533
23	protein polyglutamylation (GO:0018095)	3.04085270
24	transmission of nerve impulse (GO:0019226)	3.01574575
25	indolalkylamine metabolic process (GO:0006586)	3.01004211
26	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.99457632
27	nonmotile primary cilium assembly (GO:0035058)	2.98432540
28	nucleobase catabolic process (GO:0046113)	2.93980344
29	reflex (GO:0060004)	2.89995259
30	retinal ganglion cell axon guidance (GO:0031290)	2.88983911
31	gamma-aminobutyric acid transport (GO:0015812)	2.87179314
32	somite development (GO:0061053)	2.85099458
33	regulation of cilium movement (GO:0003352)	2.82105606
34	behavioral response to ethanol (GO:0048149)	2.81899784
35	regulation of action potential (GO:0098900)	2.80878774
36	sympathetic nervous system development (GO:0048485)	2.78474243
37	epithelial cilium movement (GO:0003351)	2.78105129
38	cornea development in camera-type eye (GO:0061303)	2.77294903
39	nephron epithelium morphogenesis (GO:0072088)	2.74777811
40	nephron tubule morphogenesis (GO:0072078)	2.74777811
41	water-soluble vitamin biosynthetic process (GO:0042364)	2.74695378
42	head development (GO:0060322)	2.74084271
43	cerebral cortex radially oriented cell migration (GO:0021799)	2.73994272
44	tryptophan metabolic process (GO:0006568)	2.71995211
45	startle response (GO:0001964)	2.71546344
46	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.70405115
47	negative regulation of astrocyte differentiation (GO:0048712)	2.69339312
48	spinal cord development (GO:0021510)	2.69141453
49	axoneme assembly (GO:0035082)	2.68761052
50	cilium morphogenesis (GO:0060271)	2.68104369
51	neuronal action potential (GO:0019228)	2.66994689
52	detection of light stimulus involved in visual perception (GO:0050908)	2.66046090
53	detection of light stimulus involved in sensory perception (GO:0050962)	2.66046090
54	otic vesicle formation (GO:0030916)	2.64319399
55	hindbrain development (GO:0030902)	2.64292938
56	neuron cell-cell adhesion (GO:0007158)	2.63233202
57	regulation of telomere maintenance (GO:0032204)	2.59029739
58	regulation of hippo signaling (GO:0035330)	2.58793649
59	central nervous system neuron axonogenesis (GO:0021955)	2.56491627
60	positive regulation of gastrulation (GO:2000543)	2.54933528
61	retinal cone cell development (GO:0046549)	2.53835412
62	vocalization behavior (GO:0071625)	2.51640579
63	cAMP catabolic process (GO:0006198)	2.51612240
64	regulation of posttranscriptional gene silencing (GO:0060147)	2.50776791
65	regulation of gene silencing by miRNA (GO:0060964)	2.50776791
66	regulation of gene silencing by RNA (GO:0060966)	2.50776791
67	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.49633045
68	renal tubule morphogenesis (GO:0061333)	2.48911065
69	negative regulation of telomere maintenance (GO:0032205)	2.48691147
70	cilium organization (GO:0044782)	2.48156904
71	inner ear receptor stereocilium organization (GO:0060122)	2.45876874
72	cilium movement (GO:0003341)	2.45640557
73	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.44946128
74	cell proliferation in forebrain (GO:0021846)	2.43151243
75	synapse assembly (GO:0007416)	2.42055561
76	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.41943158
77	central nervous system projection neuron axonogenesis (GO:0021952)	2.41617119
78	olfactory bulb development (GO:0021772)	2.41449502
79	sulfation (GO:0051923)	2.41416167
80	cilium assembly (GO:0042384)	2.41170066
81	membrane depolarization during action potential (GO:0086010)	2.40834893
82	retina layer formation (GO:0010842)	2.40746379
83	regulation of neurotransmitter uptake (GO:0051580)	2.40697810
84	embryonic epithelial tube formation (GO:0001838)	2.40072929
85	peristalsis (GO:0030432)	2.39843859
86	appendage development (GO:0048736)	2.38805850
87	limb development (GO:0060173)	2.38805850
88	glutamate receptor signaling pathway (GO:0007215)	2.38492214
89	neuron recognition (GO:0008038)	2.37837466
90	replication fork processing (GO:0031297)	2.37814385
91	photoreceptor cell maintenance (GO:0045494)	2.37660418
92	protein K11-linked deubiquitination (GO:0035871)	2.36255161
93	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.35194595
94	indole-containing compound metabolic process (GO:0042430)	2.35113385
95	regulation of collateral sprouting (GO:0048670)	2.33870909
96	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.33388881
97	rhodopsin mediated signaling pathway (GO:0016056)	2.32879443
98	amine catabolic process (GO:0009310)	2.32412804
99	cellular biogenic amine catabolic process (GO:0042402)	2.32412804
100	dentate gyrus development (GO:0021542)	2.32258350

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.49343382
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.41730950
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.39860522
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.21927789
5	VDR_22108803_ChIP-Seq_LS180_Human	2.91906746
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.81893380
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69928202
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.58411139
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.49796423
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.38599678
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.35446716
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.28145867
13	FUS_26573619_Chip-Seq_HEK293_Human	2.23595376
14	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.22819098
15	EWS_26573619_Chip-Seq_HEK293_Human	2.15825622
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.13504314
17	P300_19829295_ChIP-Seq_ESCs_Human	2.11470125
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.08725973
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.90951737
20	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.87490967
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.84724989
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80426690
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79329619
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.78015553
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.74714295
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.73337036
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.69428519
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67129554
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.63230937
30	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.61731661
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.61731661
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59662056
33	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.58702736
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.58691131
35	STAT3_23295773_ChIP-Seq_U87_Human	1.58269300
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.55673015
37	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55050593
38	TCF4_23295773_ChIP-Seq_U87_Human	1.54977783
39	REST_21632747_ChIP-Seq_MESCs_Mouse	1.53310373
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.51227200
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51227200
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51117247
43	AR_25329375_ChIP-Seq_VCAP_Human	1.49024706
44	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.45997061
45	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44278759
46	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.44026620
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.43850819
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.42805276
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.42796557
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40390003
51	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.39634994
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39103028
53	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.37559304
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35708406
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35663608
56	AR_21572438_ChIP-Seq_LNCaP_Human	1.34269589
57	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.31700288
58	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30610271
59	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.30164840
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27849908
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26627248
62	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.26059667
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.24860357
64	IRF1_19129219_ChIP-ChIP_H3396_Human	1.24085875
65	TCF4_22108803_ChIP-Seq_LS180_Human	1.23955389
66	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23827910
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22631731
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.20146478
69	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.18491300
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18217963
71	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.17534081
72	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.17364058
73	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.15241826
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14444253
75	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14047851
76	TP53_22573176_ChIP-Seq_HFKS_Human	1.13434330
77	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.13268082
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12548516
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12548516
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11515772
81	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11369168
82	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.09176446
83	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.08582292
84	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08466540
85	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.06347917
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06211226
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.05956665
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.04178106
89	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.03414246
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02889768
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02605897
92	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02248053
93	KDM2B_26808549_Chip-Seq_REH_Human	1.01756265
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01382609
95	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.01190874
96	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.98889834
97	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.98629465
98	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98620430
99	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.98251655
100	MYC_18940864_ChIP-ChIP_HL60_Human	0.98049525

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	2.46145117
2	MP0003880_abnormal_central_pattern	2.35820940
3	MP0001968_abnormal_touch/_nociception	2.34594188
4	MP0008877_abnormal_DNA_methylation	2.32646792
5	MP0006292_abnormal_olfactory_placode	2.31185091
6	MP0005551_abnormal_eye_electrophysiolog	2.22613749
7	MP0000569_abnormal_digit_pigmentation	2.18520824
8	MP0003136_yellow_coat_color	2.04233033
9	MP0002736_abnormal_nociception_after	2.01674220
10	MP0006072_abnormal_retinal_apoptosis	1.96669109
11	MP0000778_abnormal_nervous_system	1.95231723
12	MP0003787_abnormal_imprinting	1.94557221
13	MP0009046_muscle_twitch	1.94131357
14	MP0005646_abnormal_pituitary_gland	1.92766713
15	MP0004885_abnormal_endolymph	1.85657935
16	MP0003890_abnormal_embryonic-extraembry	1.79135593
17	MP0001984_abnormal_olfaction	1.77945401
18	MP0001486_abnormal_startle_reflex	1.75641798
19	MP0009745_abnormal_behavioral_response	1.75327221
20	MP0006276_abnormal_autonomic_nervous	1.73827572
21	MP0000631_abnormal_neuroendocrine_gland	1.71929034
22	MP0002837_dystrophic_cardiac_calcinosis	1.71724096
23	MP0002272_abnormal_nervous_system	1.69770218
24	MP0001986_abnormal_taste_sensitivity	1.68271588
25	MP0003195_calcinosis	1.66682213
26	MP0004133_heterotaxia	1.65492837
27	MP0004142_abnormal_muscle_tone	1.63404422
28	MP0002638_abnormal_pupillary_reflex	1.60927135
29	MP0001485_abnormal_pinna_reflex	1.58321464
30	MP0003646_muscle_fatigue	1.58168925
31	MP0004043_abnormal_pH_regulation	1.54987157
32	MP0002876_abnormal_thyroid_physiology	1.52444336
33	MP0005253_abnormal_eye_physiology	1.51409048
34	MP0000427_abnormal_hair_cycle	1.48594190
35	MP0003635_abnormal_synaptic_transmissio	1.48417060
36	MP0002938_white_spotting	1.48361859
37	MP0002557_abnormal_social/conspecific_i	1.47336318
38	MP0008872_abnormal_physiological_respon	1.44983653
39	MP0002572_abnormal_emotion/affect_behav	1.44953551
40	MP0002064_seizures	1.44541609
41	MP0003122_maternal_imprinting	1.44462349
42	MP0003121_genomic_imprinting	1.43033393
43	MP0004924_abnormal_behavior	1.42934657
44	MP0005386_behavior/neurological_phenoty	1.42934657
45	MP0001529_abnormal_vocalization	1.39752422
46	MP0002734_abnormal_mechanical_nocicepti	1.36148291
47	MP0002067_abnormal_sensory_capabilities	1.35537965
48	MP0005645_abnormal_hypothalamus_physiol	1.31212322
49	MP0004145_abnormal_muscle_electrophysio	1.31082882
50	MP0002063_abnormal_learning/memory/cond	1.30566875
51	MP0004742_abnormal_vestibular_system	1.29353847
52	MP0002184_abnormal_innervation	1.26480399
53	MP0002653_abnormal_ependyma_morphology	1.25774231
54	MP0002735_abnormal_chemical_nociception	1.25589419
55	MP0002733_abnormal_thermal_nociception	1.22919052
56	MP0004215_abnormal_myocardial_fiber	1.22675860
57	MP0003937_abnormal_limbs/digits/tail_de	1.21141341
58	MP0001970_abnormal_pain_threshold	1.20813023
59	MP0002751_abnormal_autonomic_nervous	1.20228452
60	MP0002160_abnormal_reproductive_system	1.18239237
61	MP0002752_abnormal_somatic_nervous	1.16890897
62	MP0003011_delayed_dark_adaptation	1.16488772
63	MP0000955_abnormal_spinal_cord	1.16229853
64	MP0004270_analgesia	1.14109971
65	MP0001501_abnormal_sleep_pattern	1.13714503
66	MP0005195_abnormal_posterior_eye	1.12129807
67	MP0004859_abnormal_synaptic_plasticity	1.08601201
68	MP0000049_abnormal_middle_ear	1.07163709
69	MP0010386_abnormal_urinary_bladder	1.05619959
70	MP0005187_abnormal_penis_morphology	1.05421718
71	MP0000647_abnormal_sebaceous_gland	1.05050612
72	MP0005367_renal/urinary_system_phenotyp	1.02860373
73	MP0000516_abnormal_urinary_system	1.02860373
74	MP0008789_abnormal_olfactory_epithelium	1.02763606
75	MP0002882_abnormal_neuron_morphology	1.01897242
76	MP0003283_abnormal_digestive_organ	1.01031124
77	MP0001188_hyperpigmentation	1.00915719
78	MP0003119_abnormal_digestive_system	0.99625950
79	MP0000566_synostosis	0.98611844
80	MP0008875_abnormal_xenobiotic_pharmacok	0.97541777
81	MP0000026_abnormal_inner_ear	0.97273933
82	MP0000538_abnormal_urinary_bladder	0.94256422
83	MP0003755_abnormal_palate_morphology	0.93901769
84	MP0000372_irregular_coat_pigmentation	0.93307674
85	MP0001440_abnormal_grooming_behavior	0.93151621
86	MP0000383_abnormal_hair_follicle	0.92669526
87	MP0005084_abnormal_gallbladder_morpholo	0.92512475
88	MP0003567_abnormal_fetal_cardiomyocyte	0.92478774
89	MP0003938_abnormal_ear_development	0.92027372
90	MP0008775_abnormal_heart_ventricle	0.90619016
91	MP0001293_anophthalmia	0.90211500
92	MP0005389_reproductive_system_phenotype	0.88621766
93	MP0001286_abnormal_eye_development	0.88451419
94	MP0005423_abnormal_somatic_nervous	0.87864720
95	MP0008995_early_reproductive_senescence	0.87488226
96	MP0004147_increased_porphyrin_level	0.86848018
97	MP0005174_abnormal_tail_pigmentation	0.86766926
98	MP0002152_abnormal_brain_morphology	0.85354086
99	MP0002234_abnormal_pharynx_morphology	0.83317236
100	MP0001963_abnormal_hearing_physiology	0.82528802

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.09406097
2	Abnormality of midbrain morphology (HP:0002418)	3.88681718
3	Molar tooth sign on MRI (HP:0002419)	3.88681718
4	Hyperventilation (HP:0002883)	3.83357705
5	Pancreatic fibrosis (HP:0100732)	3.71025868
6	Nephronophthisis (HP:0000090)	3.68943320
7	True hermaphroditism (HP:0010459)	3.62270620
8	Congenital stationary night blindness (HP:0007642)	3.25297788
9	Abnormality of the renal medulla (HP:0100957)	3.25080877
10	Type II lissencephaly (HP:0007260)	3.23022673
11	Chronic hepatic failure (HP:0100626)	3.08434180
12	Abnormality of the renal cortex (HP:0011035)	2.95047818
13	Medial flaring of the eyebrow (HP:0010747)	2.79474770
14	Abnormality of the labia minora (HP:0012880)	2.77619058
15	Inability to walk (HP:0002540)	2.63625721
16	Broad-based gait (HP:0002136)	2.61592400
17	Cerebellar dysplasia (HP:0007033)	2.61442857
18	Cystic liver disease (HP:0006706)	2.60208109
19	Abnormal drinking behavior (HP:0030082)	2.48957764
20	Polydipsia (HP:0001959)	2.48957764
21	Lissencephaly (HP:0001339)	2.44540200
22	Tubular atrophy (HP:0000092)	2.43906139
23	Gaze-evoked nystagmus (HP:0000640)	2.41594136
24	Optic nerve hypoplasia (HP:0000609)	2.41197593
25	Gait imbalance (HP:0002141)	2.38100654
26	Drooling (HP:0002307)	2.35746422
27	Progressive cerebellar ataxia (HP:0002073)	2.31955379
28	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.31563020
29	Progressive inability to walk (HP:0002505)	2.31293655
30	Protruding tongue (HP:0010808)	2.28674964
31	Congenital primary aphakia (HP:0007707)	2.22698034
32	Absent speech (HP:0001344)	2.22042967
33	Patellar aplasia (HP:0006443)	2.21010449
34	Abolished electroretinogram (ERG) (HP:0000550)	2.19014079
35	Focal seizures (HP:0007359)	2.17863717
36	Genital tract atresia (HP:0001827)	2.16139936
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.16118450
38	Febrile seizures (HP:0002373)	2.15480870
39	Vaginal atresia (HP:0000148)	2.13549697
40	Nephrogenic diabetes insipidus (HP:0009806)	2.12860874
41	Attenuation of retinal blood vessels (HP:0007843)	2.10214065
42	Polyuria (HP:0000103)	2.09260765
43	Excessive salivation (HP:0003781)	2.08557346
44	Sclerocornea (HP:0000647)	2.08265940
45	Genetic anticipation (HP:0003743)	2.07223196
46	Oligodactyly (hands) (HP:0001180)	2.05204688
47	Aplasia/Hypoplasia of the patella (HP:0006498)	2.04401673
48	Pendular nystagmus (HP:0012043)	2.02368618
49	Pachygyria (HP:0001302)	2.01811726
50	Renal cortical cysts (HP:0000803)	2.01602235
51	Focal motor seizures (HP:0011153)	1.99160022
52	Colon cancer (HP:0003003)	1.98359518
53	Keratoconus (HP:0000563)	1.98258953
54	Increased corneal curvature (HP:0100692)	1.98258953
55	Thyroid-stimulating hormone excess (HP:0002925)	1.96338709
56	Narrow forehead (HP:0000341)	1.92785719
57	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92210597
58	Abnormality of alanine metabolism (HP:0010916)	1.88803534
59	Hyperalaninemia (HP:0003348)	1.88803534
60	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.88803534
61	Bile duct proliferation (HP:0001408)	1.88429249
62	Abnormal biliary tract physiology (HP:0012439)	1.88429249
63	Intestinal atresia (HP:0011100)	1.88108081
64	Septo-optic dysplasia (HP:0100842)	1.87907370
65	Anencephaly (HP:0002323)	1.87600756
66	Decreased central vision (HP:0007663)	1.87487067
67	Decreased circulating renin level (HP:0003351)	1.87357083
68	Chorioretinal atrophy (HP:0000533)	1.86827556
69	Clumsiness (HP:0002312)	1.85982738
70	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.85442441
71	Postaxial foot polydactyly (HP:0001830)	1.83886475
72	Postaxial hand polydactyly (HP:0001162)	1.83434554
73	Dandy-Walker malformation (HP:0001305)	1.80481364
74	Widely spaced teeth (HP:0000687)	1.78087901
75	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.77347498
76	Concave nail (HP:0001598)	1.77304968
77	Congenital hepatic fibrosis (HP:0002612)	1.77235601
78	Absent/shortened dynein arms (HP:0200106)	1.74862359
79	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.74862359
80	Hypomagnesemia (HP:0002917)	1.74270644
81	Small hand (HP:0200055)	1.73514740
82	Male pseudohermaphroditism (HP:0000037)	1.72869432
83	Furrowed tongue (HP:0000221)	1.72173685
84	Poor coordination (HP:0002370)	1.70580342
85	Hypoplastic ischia (HP:0003175)	1.69871235
86	Fair hair (HP:0002286)	1.69688469
87	Anophthalmia (HP:0000528)	1.69491956
88	Severe muscular hypotonia (HP:0006829)	1.68478086
89	Retinal dysplasia (HP:0007973)	1.67702136
90	Polyphagia (HP:0002591)	1.67268585
91	Methylmalonic acidemia (HP:0002912)	1.67119847
92	Neoplasm of the adrenal cortex (HP:0100641)	1.66912487
93	Abnormal pancreas size (HP:0012094)	1.66225779
94	Hyperglycinuria (HP:0003108)	1.65616299
95	Dialeptic seizures (HP:0011146)	1.65445471
96	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.63333019
97	Bony spicule pigmentary retinopathy (HP:0007737)	1.63209859
98	Tachypnea (HP:0002789)	1.63149308
99	Abnormal urine output (HP:0012590)	1.61807488
100	Short foot (HP:0001773)	1.60244041

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.48066104
2	CASK	2.91958457
3	BMPR1B	2.67721849
4	WNK4	2.57565150
5	STK38L	2.54553137
6	WNK3	2.46815639
7	PINK1	2.40532149
8	MAP4K2	2.35252090
9	MARK1	2.34656330
10	TNIK	2.34155012
11	ADRBK2	2.33816772
12	GRK1	2.08347252
13	MAPK13	2.01842136
14	STK39	1.95545665
15	MKNK2	1.86368057
16	INSRR	1.82732360
17	FGFR2	1.80827089
18	ZAK	1.80217890
19	NUAK1	1.78042660
20	MAP3K4	1.76327944
21	OXSR1	1.62542002
22	ACVR1B	1.61224641
23	PAK3	1.43384437
24	NTRK3	1.43355781
25	PNCK	1.40152725
26	TAOK3	1.30542733
27	EPHA4	1.28397154
28	AKT3	1.28282913
29	TRIM28	1.27623497
30	TLK1	1.24417631
31	DYRK2	1.22670597
32	NTRK2	1.15003062
33	DAPK2	1.14318080
34	PLK2	1.10956260
35	PRKCG	1.07259353
36	MKNK1	1.05487419
37	WNK1	1.01104308
38	PRKCE	0.95279821
39	OBSCN	0.95277012
40	CAMK1G	0.95124308
41	MAP2K7	0.94994029
42	TGFBR1	0.94079093
43	ADRBK1	0.86542756
44	SGK2	0.85987130
45	CSNK1G2	0.83452683
46	EIF2AK3	0.81546350
47	PIK3CA	0.81533503
48	NLK	0.76611282
49	CDC7	0.76202153
50	LATS1	0.76027923
51	PHKG1	0.74573586
52	PHKG2	0.74573586
53	CSNK1G1	0.74227121
54	BCR	0.71066658
55	STK11	0.70470544
56	STK38	0.68657478
57	SGK223	0.68241228
58	SGK494	0.68241228
59	CAMK1D	0.68226307
60	TIE1	0.65125335
61	CAMK1	0.61674884
62	PLK3	0.61597454
63	CAMK2A	0.61107088
64	PKN1	0.60246597
65	MUSK	0.58697363
66	STK3	0.57481213
67	ERBB2	0.57236098
68	FLT3	0.55771466
69	CDK3	0.54333680
70	CSNK1D	0.53082009
71	CSNK1A1L	0.50753672
72	BRSK2	0.50620064
73	CSNK1G3	0.49932987
74	MINK1	0.49735499
75	DYRK1A	0.48175896
76	PTK2B	0.45532342
77	PRKAA1	0.45337503
78	PRKG1	0.43488026
79	MAPK15	0.42813805
80	PRKACA	0.42320826
81	CSNK1A1	0.42039012
82	NEK2	0.41905119
83	CDK5	0.41389032
84	PRKAA2	0.41330915
85	ERBB3	0.40295210
86	CSNK1E	0.39524175
87	SIK2	0.38475029
88	TAF1	0.37233678
89	PRKCZ	0.37118983
90	PLK1	0.37052737
91	MAPKAPK3	0.36938049
92	ATM	0.36457906
93	MAPKAPK5	0.36259242
94	VRK1	0.35115595
95	MAP2K4	0.34785921
96	TEC	0.34447752
97	CAMKK2	0.30778013
98	PRKACB	0.30430056
99	ATR	0.30373456
100	SGK1	0.29719122

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.01419178
2	Nicotine addiction_Homo sapiens_hsa05033	2.80206987
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.41293733
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.33517176
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.27262002
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.22438034
7	Butanoate metabolism_Homo sapiens_hsa00650	2.02812062
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.01050396
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.01026712
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.95449611
11	Taste transduction_Homo sapiens_hsa04742	1.91448290
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.82705994
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.74984118
14	Morphine addiction_Homo sapiens_hsa05032	1.68962245
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.66615205
16	Basal transcription factors_Homo sapiens_hsa03022	1.66264814
17	Propanoate metabolism_Homo sapiens_hsa00640	1.65907238
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.63047622
19	Circadian entrainment_Homo sapiens_hsa04713	1.63018485
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.62956682
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.61199165
22	Glutamatergic synapse_Homo sapiens_hsa04724	1.57479868
23	Olfactory transduction_Homo sapiens_hsa04740	1.54890883
24	Caffeine metabolism_Homo sapiens_hsa00232	1.54680236
25	Homologous recombination_Homo sapiens_hsa03440	1.49470592
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.47638398
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.43713785
28	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.40046975
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.39707927
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.37899974
31	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.37281137
32	Insulin secretion_Homo sapiens_hsa04911	1.35890145
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.35817856
34	GABAergic synapse_Homo sapiens_hsa04727	1.27395179
35	Protein export_Homo sapiens_hsa03060	1.22699756
36	Retinol metabolism_Homo sapiens_hsa00830	1.18857062
37	Serotonergic synapse_Homo sapiens_hsa04726	1.18438819
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.13360818
39	ABC transporters_Homo sapiens_hsa02010	1.13205105
40	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.11014648
41	Oxidative phosphorylation_Homo sapiens_hsa00190	1.08391982
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.06502955
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.06108655
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.05253145
45	Dopaminergic synapse_Homo sapiens_hsa04728	1.04279887
46	Long-term depression_Homo sapiens_hsa04730	1.01845133
47	RNA polymerase_Homo sapiens_hsa03020	1.00894656
48	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00443067
49	Peroxisome_Homo sapiens_hsa04146	1.00316783
50	Basal cell carcinoma_Homo sapiens_hsa05217	1.00110674
51	RNA degradation_Homo sapiens_hsa03018	0.99100062
52	Calcium signaling pathway_Homo sapiens_hsa04020	0.98380661
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.97382004
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.96797404
55	Circadian rhythm_Homo sapiens_hsa04710	0.95951543
56	Cocaine addiction_Homo sapiens_hsa05030	0.95775843
57	Salivary secretion_Homo sapiens_hsa04970	0.90874007
58	Regulation of autophagy_Homo sapiens_hsa04140	0.90682966
59	Amphetamine addiction_Homo sapiens_hsa05031	0.88307187
60	Non-homologous end-joining_Homo sapiens_hsa03450	0.87211041
61	Parkinsons disease_Homo sapiens_hsa05012	0.84065104
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81273805
63	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.81228361
64	Cholinergic synapse_Homo sapiens_hsa04725	0.78506079
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.78179625
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.77796984
67	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.76353356
68	Axon guidance_Homo sapiens_hsa04360	0.76242654
69	cAMP signaling pathway_Homo sapiens_hsa04024	0.75759813
70	Lysine degradation_Homo sapiens_hsa00310	0.75059211
71	Hippo signaling pathway_Homo sapiens_hsa04390	0.73944243
72	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.72651235
73	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.71587912
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.71169972
75	Histidine metabolism_Homo sapiens_hsa00340	0.70148936
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69568634
77	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.66824895
78	Steroid biosynthesis_Homo sapiens_hsa00100	0.66523823
79	Gastric acid secretion_Homo sapiens_hsa04971	0.64660211
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64514488
81	Huntingtons disease_Homo sapiens_hsa05016	0.61086395
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.59995335
83	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.59669989
84	Alzheimers disease_Homo sapiens_hsa05010	0.58961816
85	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.57907268
86	Wnt signaling pathway_Homo sapiens_hsa04310	0.56522874
87	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.56422855
88	Renin secretion_Homo sapiens_hsa04924	0.56230144
89	One carbon pool by folate_Homo sapiens_hsa00670	0.53032602
90	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.50770098
91	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.48945926
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.47883533
93	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.46780708
94	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.45254370
95	Fatty acid degradation_Homo sapiens_hsa00071	0.44928019
96	Metabolic pathways_Homo sapiens_hsa01100	0.42199330
97	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.41505347
98	Purine metabolism_Homo sapiens_hsa00230	0.40795014
99	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.34179432
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.33664193

ZNF605

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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